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3. Golimumab effectiveness in biologic inadequate responding patients with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis in real-life from the Italian registry GISEA

Author

Iannone, Florenzo, Favalli, Ennio G., Caporali, Roberto, D’Angelo, Salvatore, Cantatore, Francesco Paolo, Sarzi-Puttini, Piercarlo, Foti, Rosario, Conti, Fabrizio, Carletto, Antonio, Gremese, Elisa, Cauli, Alberto, Ramonda, Roberta, Palermo, Adalgisa, Epis, Oscar, Priora, Marta, Bergossi, Francesca, Frediani, Bruno, Salaffi, Fausto, Lopalco, Giuseppe, Cacciapaglia, Fabio, Marchesoni, Antonio, Biggioggiero, Martina, Bugatti, Serena, Balduzzi, Silvia, Carriero, Antonio, Corrado, Addolorata, Bongiovanni, Sara, Benenati, Alessia, Miranda, Francesca, Fracassi, Elena, Perra, Daniela, Ferraccioli, Gianfranco, and Lapadula, Giovanni

Published
2021
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4. Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study

Author

Sarzi-Puttini, Piercarlo, Marotto, Daniela, Caporali, Roberto, Montecucco, Carlo Maurizio, Favalli, Ennio Giulio, Franceschini, Franco, Fredi, Michela, Balduzzi, Silvia, Bazzani, Chiara, Bongiovanni, Sara, Giorgi, Valeria, Batticciotto, Alberto, Cappelli, Antonella, Balzarini, Patrizia, Dagna, Lorenzo, Sartorelli, Silvia, Ravagnani, Viviana, Tamanini, Silvia, Farah, Sonia, Faggioli, Paola, Castelnovo, Laura, Lurati, Alfredo Maria, Galli, Massimo, and Salaffi, Fausto

Published
2021
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5. Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Author

Ruscitti, Piero, Cipriani, Paola, Liakouli, Vasiliki, Iacono, Daniela, Pantano, Ilenia, Margiotta, Domenico Paolo Emanuele, Navarini, Luca, Destro Castaniti, Giulia Maria, Maruotti, Nicola, Di Scala, Gerardo, Picciariello, Licia, Caso, Francesco, Bongiovanni, Sara, Grembiale, Rosa Daniela, Atzeni, Fabiola, Scarpa, Raffaele, Perosa, Federico, Emmi, Giacomo, Cantatore, Francesco Paolo, Guggino, Giuliana, Afeltra, Antonella, Ciccia, Francesco, and Giacomelli, Roberto

Published
2019
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9. Common-sense model of self-regulation to cluster fibromyalgia patients: results from a cross-sectional study in Italy

Author

Tenti, Michael, primary, Raffaeli, William, additional, Malafoglia, Valentina, additional, Paroli, Mery, additional, Ilari, Sara, additional, Muscoli, Carolina, additional, Fraccaroli, Elena, additional, Bongiovanni, Sara, additional, Gioia, Chiara, additional, Iannuccelli, Cristina, additional, Di Franco, Manuela, additional, and Gremigni, Paola, additional

Published
2022
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10. Cannabis and Autoimmunity: Possible Mechanisms of Action

Author

Giorgi,Valeria, Marotto,Daniela, Batticciotto,Alberto, Atzeni,Fabiola, Bongiovanni,Sara, and Sarzi-Puttini,Piercarlo

Subjects
ImmunoTargets and Therapy
Abstract

Valeria Giorgi1 1, Daniela Marotto2 2, Alberto Batticciotto3 3, Fabiola Atzeni4 4, Sara Bongiovanni1 1, Piercarlo Sarzi-Puttini1 1 1Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan University School of Medicine, Milan, Italy; 2Rheumatology Unit, ATS Sardegna, P. Dettori Hospital, Tempio Pausania, Italy; 3Rheumatology Unit, Internal Medicine Department, ASST Settelaghi, Ospedale Di Circolo - Fondazione Macchi, Varese, Italy; 4Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyCorrespondence: Valeria Giorgi Email vale.gio@fastwebnet.itAbstract: Medical cannabis (MC) describes the usually inhaled or ingested use of a cannabis plant or cannabis extract for medicinal purposes. The action of whole cannabis plants is extremely complex because their large number of active compounds not only bind to a plethora of different receptors but also interact with each other both synergistically and otherwise. Renewed interest in the medicinal properties of cannabis has led to increasing research into the practical uses of cannabis derivatives, and it has been found that the endocannabinoid system (particularly CB2 receptor activation) is a possible target for the treatment of inflammatory and the autoimmune diseases related to immune cell activation. However, in vivo findings still lack, creating difficulties in applying translational cannabinoid research to human immune functions. In this review, we summarized the main mechanisms of action of medical cannabis plant especially regarding the immune system and the endocannabinoid system, looking at preliminary clinical data in three most important autoimmune diseases of three different specialities: rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.Keywords: cannabis, cannabis derivatives, cannabidiol, tetrahydrocannabinol, terpenes, autoimmunity, auto-antibodies

Published
2021

11. Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study

Author

Ruscitti, Piero, primary, Cipriani, Paola, additional, Liakouli, Vasiliki, additional, Iacono, Daniela, additional, Pantano, Ilenia, additional, Margiotta, Domenico Paolo Emanuele, additional, Navarini, Luca, additional, Destro Castaniti, Giulia Maria, additional, Maruotti, Nicola, additional, Di Scala, Gerardo, additional, Caso, Francesco, additional, Bongiovanni, Sara, additional, Grembiale, Rosa Daniela, additional, Atzeni, Fabiola, additional, Scarpa, Raffaele, additional, Perosa, Federico, additional, Emmi, Giacomo, additional, Cantatore, Francesco Paolo, additional, Guggino, Giuliana, additional, Afeltra, Antonella, additional, Ciccia, Francesco, additional, and Giacomelli, Roberto, additional

Published
2021
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13. The effect of novel coronavirus disease-2019 (COVID-19) on fibromyalgia syndrome

Author

Salaffi, Fausto, primary, Giorgi, Valeria, additional, Sirotti, Silvia, additional, Bongiovanni, Sara, additional, Farah, Sonia, additional, Bazzichi, Laura, additional, Marotto, Daniela, additional, Atzeni, Fabiola, additional, Rizzi, Maurizio, additional, Batticciotto, Alberto, additional, Lombardi, Giovanni, additional, Galli, Massimo, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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14. Use of rituximab in a multicentre cohort of patients with rheumatic diseases during the outbreak of novel SARS-COV-2 infection

Author

Batticciotto, Alberto, primary, Marotto, Daniela, additional, Giorgi, Valeria, additional, Balzarini, Patrizia, additional, Favalli, Ennio Giulio, additional, Balduzzi, Silvia, additional, Fredi, Micaela, additional, Bazzani, Chiara, additional, Sartorelli, Silvia, additional, Ravagnani, Viviana, additional, Tamanini, Silvia, additional, Castelnovo, Laura, additional, Lurati, Alfredo Maria, additional, Farah, Sonia, additional, Bongiovanni, Sara, additional, Caporali, Roberto, additional, Dagna, Lorenzo, additional, Faggioli, Paola, additional, Franceschini, Franco, additional, Montecucco, Carlo Maurizio, additional, Salaffi, Fausto, additional, Galli, Massimo, additional, Cappelli, Antonella, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2021
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15. Additional file 1: of Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Author

Ruscitti, Piero, Cipriani, Paola, Liakouli, Vasiliki, Iacono, Daniela, Pantano, Ilenia, Margiotta, Domenico, Navarini, Luca, Castaniti, Giulia Destro, Maruotti, Nicola, Scala, Gerardo Di, Picciariello, Licia, Caso, Francesco, Bongiovanni, Sara, Grembiale, Rosa, Atzeni, Fabiola, Scarpa, Raffaele, Perosa, Federico, Emmi, Giacomo, Cantatore, Francesco, Guggino, Giuliana, Afeltra, Antonella, Ciccia, Francesco, and Giacomelli, Roberto

Abstract

STROBE 2007 (v4) checklist of items to be included in reports of observational studies in epidemiology* (DOC 96 kb)

Published
2019
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19. Measurement of Serum Klotho in Systemic Sclerosis

Author

Talotta, Rossella, primary, Bongiovanni, Sara, additional, Letizia, Teresa, additional, Rigamonti, Federica, additional, Ditto, Maria Chiara, additional, Atzeni, Fabiola, additional, Salaffi, Fausto, additional, Batticciotto, Alberto, additional, Gerardi, Maria Chiara, additional, Antivalle, Marco, additional, Vago, Tarcisio, additional, Benucci, Maurizio, additional, and Sarzi-Puttini, Piercarlo, additional

Published
2017
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20. Biomarkers in Rheumatoid Arthritis.

Author

Atzeni, Fabiola, Talotta, Rossella, Masala, Ignazio F., Bongiovanni, Sara, Boccassini, Laura, and Sarzi-Puttini, Piercarlo

Published
2017

21. Certainties and uncertainties concerning the contribution of pericytes to the pathogenesis of systemic sclerosis

Author

Talotta, Rossella, Atzeni, Fabiola, Ditto, Maria Chiara, Gerardi, Maria Chiara, Batticciotto, Alberto, Bongiovanni, Sara, and Puttini, Piercarlo Sarzi

Abstract

The role of pericytes in systemic sclerosis (SSc) is unclear because of the difficulty in phenotyping them. They are mainly distributed in the pre-capillary, capillary and post-capillary abluminal side of non-muscular micro-vessels, express platelet-derived growth factor receptors (PDGFRs), and preside over vascular integrity and regeneration. By establishing close contact with many endothelial cells, a single pericyte can regulate ion influx, mechanical stress, leukocyte diapedesis, and platelet activation. Moreover, under pathological conditions such as SSc, pericytes may acquire a contractile phenotype and respond to various stimuli, including endothelin, angiotensin II and reactive oxygen species. The pericytes of SSc patients share some molecular patterns with myofibroblasts or fibroblasts, including A disintegrin and metalloproteinase domain 12 (ADAM-12), α-smooth muscle actin (α-SMA), the extra domain A (ED-A) variant of fibronectin, and Thy-1. Following stimulation with PDGF-β or transforming growth factor-β (TGF-β), pericytes may acquire a myofibroblast phenotype, and produce extracellular matrix or indirectly promote fibroblast activation. They may also contribute to fibrosis by means of epigenetic regulation. The pericyte plasmalemma is particularly rich in caveolae containing caveolin-1, a deficit of which has been associated with defective vessel tone control and lung fibrosis in mice. Consequently, dysfunctional pericytes may underlie the microangiopathy and fibrosis observed in SSc patients. However, given its variability in biological behaviour and the lack of a pan-pericyte marker, the exact role of these cells in SSc warrants further investigation.

Published
2018
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22. Termoresistenza di un ceppo di Saccharomyces cerevisiae isolato da bevande in presenza di citral

Author

Bongiovanni, Sara, thesis supervisor: Gardini, Fausto, Bongiovanni, Sara, and thesis supervisor: Gardini, Fausto

Abstract

I lieviti sono la principale causa di “spoilage” negli alimenti caratterizzati da elevata concentrazione zuccherina e basso pH. Il metodo adottato tradizionalmente per controllarne lo sviluppo è il trattamento termico, anche se l’industria alimentare sta cercando alternative valide per ridurre il danno termico sui prodotti. Una possibile soluzione è l’utilizzo di composti d’aroma, la cui attività antimicrobica è dimostrata, anche in sinergia con il trattamento termico. Lo scopo dell’elaborato era verificare la resistenza di un ceppo di Saccharomyces cerevisiae sottoposto a trattamento termico, in presenza o meno del composto d’aroma citral. È stato valutato, inoltre, l’effetto del pH del mezzo, poiché studi precedenti avevano evidenziato un’interazione tra pH e citral. Per valutare la termoresistenza si è utilizzato oltre al tradizionale campionamento in piastra anche la citometria di flusso, una tecnica innovativa che permette di ottenere informazioni a livello di singola cellula. Il lavoro è stato diviso in due parti: i) determinazione delle cinetiche di morte a 60°C in presenza di concentrazioni di citral pari ad ¼ e ½ della MIC mediante campionamento in piastra; ii) effetto di un trattamento a 60°C per 10 minuti (in presenza di citral o meno) su S. cerevisiae: i campioni sono stati analizzati a seguito del trattamento e dopo 3 ore, tramite campionamento in piastra ed analisi citofluorimetrica. I risultati hanno confermato la sinergia tra citral e trattamento termico, con cinetiche di morte più rapide a pH 4. Tuttavia l’analisi citofluorimetrica ha riscontrato una maggiore percentuale di cellule morte a pH 6 (con anche una maggiore permeabilità di membrana). Dopo 3 ore le cellule non hanno recuperato la vitalità e i valori di permeabilità di membrana erano pressoché invariati. La combinazione di tecniche tradizionali e citofluorimetriche si è rivelata fondamentale per meglio studiare l’effetto di questi trattamenti e il meccanismo di azione del citral.

23. Termoresistenza di un ceppo di Saccharomyces cerevisiae isolato da bevande in presenza di citral

Author

Bongiovanni, Sara, thesis supervisor: Gardini, Fausto, Bongiovanni, Sara, and thesis supervisor: Gardini, Fausto

Abstract

I lieviti sono la principale causa di “spoilage” negli alimenti caratterizzati da elevata concentrazione zuccherina e basso pH. Il metodo adottato tradizionalmente per controllarne lo sviluppo è il trattamento termico, anche se l’industria alimentare sta cercando alternative valide per ridurre il danno termico sui prodotti. Una possibile soluzione è l’utilizzo di composti d’aroma, la cui attività antimicrobica è dimostrata, anche in sinergia con il trattamento termico. Lo scopo dell’elaborato era verificare la resistenza di un ceppo di Saccharomyces cerevisiae sottoposto a trattamento termico, in presenza o meno del composto d’aroma citral. È stato valutato, inoltre, l’effetto del pH del mezzo, poiché studi precedenti avevano evidenziato un’interazione tra pH e citral. Per valutare la termoresistenza si è utilizzato oltre al tradizionale campionamento in piastra anche la citometria di flusso, una tecnica innovativa che permette di ottenere informazioni a livello di singola cellula. Il lavoro è stato diviso in due parti: i) determinazione delle cinetiche di morte a 60°C in presenza di concentrazioni di citral pari ad ¼ e ½ della MIC mediante campionamento in piastra; ii) effetto di un trattamento a 60°C per 10 minuti (in presenza di citral o meno) su S. cerevisiae: i campioni sono stati analizzati a seguito del trattamento e dopo 3 ore, tramite campionamento in piastra ed analisi citofluorimetrica. I risultati hanno confermato la sinergia tra citral e trattamento termico, con cinetiche di morte più rapide a pH 4. Tuttavia l’analisi citofluorimetrica ha riscontrato una maggiore percentuale di cellule morte a pH 6 (con anche una maggiore permeabilità di membrana). Dopo 3 ore le cellule non hanno recuperato la vitalità e i valori di permeabilità di membrana erano pressoché invariati. La combinazione di tecniche tradizionali e citofluorimetriche si è rivelata fondamentale per meglio studiare l’effetto di questi trattamenti e il meccanismo di azione del citral.

24. Racial differences in systemic sclerosis disease presentation: A European Scleroderma Trials and Research group study

Author

Jaeger, Veronika K, Tikly, Mohammed, Dong, Xu, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Mengtao, Li, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich, A, Randone, Sb, Bannert, B, Iannone, F, Maurer, B, Jordan, S, Dobrota, R, Becker, M, Mihai, C, Becvarare, R, Tomčík, M, Bielecka, Ok, Gindzienska-Sieskiewicz, E, Karaszewska, K, Cutolo, M, Pizzorni, C, Paolino, S, Sulli, A, Ruaro, B, Alessandri, E, Riccardi, A, Giacco, V, Messitini, V, Irace, R, Kedor, C, Casteleyn, V, Hilger, J, Hoeppner, J, Rednic, S, Szabo, I, Petcu, A, Avouac, J, Camelia, F, Desbas, C, Vlachoyiannopoulos, P, Montecucco, C, Caporali, R, Cavagna, L, Stork, J, Inanc, M, Joven, Be, Novak, S, Anic, F, Varju, C, Minier, T, Chizzolini, C, Allai, D, Kucharz, Ej, Kotulska, A, Kopec-Medrek, M, Widuchowska, M, Dolnicar, As, Coleiro, B, Gabrielli, A, Manfredi, L, Benfaremo, D, Ferrarini, A, Bancel, Df, Hij, A, Lansiaux, P, Lazzaroni, Mg, Hesselstrand, R, Wuttge, D, Andréasson, R, Martinovic, D, Bozic, I, Radic, M, Braun-Moscovici, Y, Monaco, Al, Furini, F, Hunzelmann, N, Moinzadeh, P, Pellerito, R, Caimmi, C, Bertoldo, E, Morovic-Vergles, J, Culo, Im, Pecher, Ac, Santamaria, Vo, Heitmann, S, Codagnone, M, Pflugfelder, J, Krasowska, D, Michalska-Jakubus, M, Seidel, M, Hasler, P, Kretschmar, S, Kohm, M, Bajocchi, G, Salvador, Mj, Silva, Japd, Stamenkovic, B, Stankovic, A, Selmi, Cf, Santis, M, Ceribelli, A, Garzanova, L, Koneva, O, Starovoytova, M, Herrick, A, Puppo, F, Negrini, S, Murdaca, G, Engelhart, M, Szücs, G, Szamosi, S, de la Puente, C, Grande, Cs, Villanueva, Mjg, Midtvedt, Sø, Hoffmann-Vold, Am, Launay, D, Sobanski, V, Riccieri, V, Vasile, M, Ionescu, Rm, Opris, D, Sha, A, Woods, A, Gheorghiu, Am, Bojinca, M, Sunderkötter, C, Ehrchen, J, Ingegnoli, F, Mouthon, L, Dunogue, B, Chaigne, B, Legendre, P, Cantatore, Fp, Corrado, A, Ullman, S, Iversen, L, von Mühlen CA, Pozzi, Mr, Eyerich, K, Lauffer, F, Wiland, P, Szmyrka-Kaczmarek, M, Sokolik, R, Morgiel, E, Madej, M, Vanthuyne, M, Frédéric, H, Alegre-Sancho, Jj, Aringer, M, Herrmann, K, Günther, C, Westhovens, R, Langhe, E, Lenaerts, J, Anic, B, Baresic, M, Mayer, M, Üprus, M, Otsa, K, Yavuz, S, Granel, B, Radominski, Sc, De, C, Müller, S, Azevedo, Vf, Mendoza, F, Busquets, J, Popa, S, Agachi, S, Zenone, T, Pileckyte, M, Stebbings, S, Mathieu, A, Vacca, A, Sampaio-Barros, Pd, Stamp, L, Solanki, K, Silva, C, Schollum, J, Barns-Graham, H, Veale, D, O'Rourke, M, Loyo, E, Tineo, C, Paulino, G, Mohamed, Waaa, Rosato, E, Gigante, A, Oksel, F, Yargucu, F, Tanaseanu, Cm, Popescu, M, Dumitrascu, A, Tiglea, I, Foti, R, Visalli, E, Benenati, A, Amato, G, Ancuta, C, Villiger, P, Adler, S, Fröhlich, J, Kayser, C, Eduardo, Al, Fathi, N, Alii, S, Ahmed, M, Hasaneen, S, Hakeem, Ee, de la PG, Lefebvre, P, Martin, Jjg, Sibilia, J, Chatelus, E, Gottenberg, Je, Chifflot, H, Litinsky, I, Galdo, Fd, Abignano, G, Eng, S, Seskute, G, Butrimiene, I, Rugiene, R, Karpec, D, Pascal, M, Kerzberg, E, Bianchi, W, Bianchi, Bv, Bianchi, Dv, Barcellos, Y, Castellví, I, Millan, M, Limonta, M, Rimar, D, Rosner, I, Slobodin, G, Couto, M, Spertini, F, Ribi, C, Buss, G, Marcoccia, A, Bondanini, F, Ciani, A, Kahl, S, Hsu, Vm, Martin, T, Poindron, V, Meghit, K, Moiseev, S, Novikov, P, Chung, L, Kolstad, K, Stark, M, Schmeiser, T, Thiele, A, Majewski, D, Zdrojewski, Z, Zaneta, S, Wierzba, K, Martínez-Barrio, J, López-Longo, Fj, Bernardino, V, Moraes-Fontes, Mf, Rodrigues, Ac, Riemekasten, G, Sommerlatte, S, Jendreck, S, Arnold, S, Levy, Y, Rezus, E, Cardoneanu, A, Burlui, Am, Pamuk, On, Puttini, Ps, Talotta, R, Bongiovanni, S, Poormoghim, H, Andalib, E, Almasi, S, Kötter, I, Krusche, M, Cuomo, G, Danzo, F, Masini, F, Gaches, F, Michaud, M, Cartos, F, Belloli, L, Casu, C, Sfikakis, P, Tektonidou, M, Furst, D, Feldman, Gr, Ramazan, Am, Nurmambet, E, Miroto, A, Suta, C, Andronache, I, Huizinga, Twj, de Vries-Bouwstra, J., Chizzolini, Carlo, Jaeger, Veronika K, Tikly, Mohammed, Xu, Dong, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Li, Mengtao, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich A, University of Zurich, Cerinic, Marco Matucci, Walker Ulrich, A, Randone, Silvia Bellando, Bannert, Bettina, Iannone, Florenzoaa, Maurer, Brittaab, Jordan, Suzanaab, Dobrota, Rucsandraab, Becker, Mikeab, Mihai, Carinaa, Becvarare, Radima, Tomcik, Michala, Bielecka, Otylia Kowala, Gindzienska-Sieskiewicz, Ewaa, Karaszewska, Katarzynaa, Cutolo, Maurizioa, Pizzorni, Carmena, Paolino, Sabrinaae, Sulli, Albertoa, Ruaro, Barbara, Alessandri, Elisa, Riccardi, Antonella, Giacco, Veronica, Messitini, Valentina, Irace, Rosaria, Kedor, Claudia, Casteleyn, Vincent, Hilger, Julia, Hoeppner, Jakob, Rednic, Simona, Szabo, Iulia, Petcu, Ana, Avouac, Jérome, Camelia, Frantz, Desbas, Carole, Vlachoyiannopoulos, Panayioti, Montecucco, Carlo Maurizio, Caporali, Roberto, Cavagna, Lorenzo, Stork, Jiri, Inanc, Murat, Joven, Beatriz E., Novak, Srdan, Anic, Felina, Varju, Cecilia, Minier, Tunde, Allai, Daniela, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Dolnicar, Alenka Sipek, Coleiro, Bernard, Gabrielli, Armando, Manfredi, Lucia, Benfaremo, Devi, Ferrarini, Alessia, Bancel, Dominique Farge, Hij, Adrian, Lazzaroni, Maria Grazia, Hesselstrand, Roger, Wuttge, Dirk, Andréasson, Kristofer, Martinovic, Duska, Bozic, Ivona, Radic, Mislav, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Furini, Federica, Hunzelmann, Nicola, Moinzadeh, Pia, Pellerito, Raffaele, Caimmi, Cristian, Bertoldo, Eugenia, Morovic-Vergles, Jadranka, Culo, Ivana Melanie, Pecher, Ann-Christian, Santamaria, Vera Ortiz, Heitmann, Stefan, Codagnone, Medeleine, Pflugfelder, Johanne, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthia, Hasler, Paul, Kretschmar, Samuel, Kohm, Michaela, Bajocchi, Gianluigi, Salvador, Maria João, Da Silva, JoséAntonio Pereira, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Ceribelli, Angela, Garzanova, Ludmila, Koneva, Olga, Starovoytova, Maya, Herrick, Ariane, Puppo, Francesco, Negrini, Simone, Murdaca, Giuseppe, Engelhart, Merete, Szücs, Gabriela, Szamosi, Szilvia, De La Puente, Carlo, Grande, Cristina Sobrino, Villanueva, Maria Jesus Garcia, Midtve, Øyvindbw, Hoffmann-Vold, Anna-Mariabw, Launay, Davidbx, Sobanski, Vincentbx, Riccieri, Valeriaby, Vasile, Massimilianoby, Stefantoni, Katia, Ionescu, Ruxandra Maria, Opris, Daniela, Sha, Ami, Woods, Adrianne, Gheorghiu, Ana Maria, Bojinca, Mihai, Sunderkötter, Cord, Ehrchen, Jan, Ingegnoli, Francesca, Mouthon, Luc, Dunogue, Bertrand, Chaigne, Benjamin, Legendre, Paul, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Von Mühlen, Carlos Alberto, Pozzi, Maria Rosa, Eyerich, Kilian, Lauffer, Felix, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Vanthuyne, Marie, Frédéric, Houssiau, Alegre-Sancho, Juan Jose, Aringer, Martin, Herrmann, Kristine, Günther, Claudia, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastião Cezar, De Souza Müller, Carolina, Feijóazevedo, Valderílio, Mendoza, Fabian, Busquets, Joanna, Popa, Sergei, Agachi, Svetlana, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Jordan, Sarah, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Stamp, Lisa, Solanki, Kamal, Silva, Cherumi, Schollum, Joanne, Barns-Graham, Helen, Veale, Dougla, O'Rourke, Marie, Loyo, Esthela, Tineo, Carmen, Paulino, Glenny, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Fröhlich, Johanne, Kayser, Cristiane, Eduardo, Andrade Lui, Fathi, Nihal, Alii, Safa, Ahmed, Marrow, Hasaneen, Samar, El Hakeem, Eman, De La Peña Lefebvre, Paloma García, Martin, Jorge Juan Gonzalez, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Del Galdo, Francesco, Abignano, Giuseppina, Eng, Sookho, Seskute, Goda, Butrimiene, Irena, Rugiene, Rita, Karpec, Diana, Pascal, Melanie, Kerzberg, Eduardo, Bianchi, Washington, Bianchi, Breno Valdetaro, Bianchi, Dante Valdetaro, Barcellos, Yeda, Castellví, Ivan, Millan, Milena, Limonta, Massimiliano, Rimar, Doron, Rosner, Itzhak, Slobodin, Gleb, Couto, Maura, Spertini, Françoi, Ribi, Camillo, Buss, Guillaume, Marcoccia, Antonella, Bondanini, Francesco, Ciani, Aldo, Kahl, Sarah, Hsu, Vivien M., Martin, Thierry, Poindron, Vincent, Meghit, Kilifa, Moiseev, Sergey, Novikov, Pavel, Chung, Lori, Kolstad, Kathleen, Stark, Marianna, Schmeiser, Tim, Thiele, Astrid, Majewski, Dominik, Zdrojewski, Zbigniew, Zaneta, Smolenska, Wierzba, Karol, Martínez-Barrio, Julia, López-Longo, Francisco Javier, Bernardino, Vera, Moraes-Fontes, Maria Francisca, Rodrigues, Ana Catarina, Riemekasten, Gabriela, Sommerlatte, Sabine, Jendreck, Sebastian, Arnold, Sabrina, Levy, Yair, Rezus, Elena, Cardoneanu, Anca, Burlui, Alexandra Maria, Pamuk, Omer Nuri, Puttini, Piercarlo Sarzi, Talotta, Rossella, Bongiovanni, Sara, Poormoghim, Hadi, Andalib, Elham, Almasi, Simin, Kötter, Ina, Krusche, Matrin, Cuomo, Giovanna, Danzo, Fiammetta, Masini, Francesco, Gaches, Franci, Michaud, Martin, Cartos, Florian, Belloli, Laura, Casu, Cinzia, Sfikakis, Petro, Tektonidou, Maria, Furst, Daniel, Feldman, Gary R., Ramazan, Ana-Maria, Nurmambet, Emel, Miroto, Amalia, Suta, Cristina, Andronache, Iulia, Huizinga, Tom W. J., De Vries-Bouwstra, Jeska, and Walker, Ulrich A.

Subjects
Male, Vital capacity, Organ manifestations, systemic sclerosis, Type I, race difference, Systemic scleroderma, Gastroenterology, Scleroderma, immunology, 0302 clinical medicine, Diffusing capacity, middle aged, pulmonary hypertension, Medicine, Pharmacology (medical), 030212 general & internal medicine, organ manifestations, races, skin and connective tissue diseases, Lung, race, pathophysiology, African Continental Ancestry Group, ddc:616, integumentary system, disease course, Hazard ratio, Races, 10051 Rheumatology Clinic and Institute of Physical Medicine, Pulmonary, Middle Aged, Blacks, cohort analysis, Autoantibodie, 3. Good health, Asians, female, priority journal, DNA Topoisomerases, Type I, Black, centromere, Cohort, Hypertension, organ manifestation, Systemic sclerosis, Female, systemic sclerosi, Human, Adult, Asian Continental Ancestry Group, medicine.medical_specialty, Hypertension, Pulmonary, European Continental Ancestry Group, Black People, 610 Medicine & health, complication, Caucasian, White People, Article, lung, 03 medical and health sciences, Black person, Rheumatology, Asian People, forced vital capacity, Internal medicine, geographic distribution, Humans, controlled study, human, DNA topoisomerase, Aged, Autoantibodies, 030203 arthritis & rheumatology, Scleroderma, Systemic, Asian, business.industry, Whites, Systemic, Odds ratio, medicine.disease, Pulmonary hypertension, major clinical study, mortality, clinical feature, business, DNA Topoisomerases, autoantibody
Abstract

Objectives Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. Methods SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. Results The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. Conclusion Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.

Published
2020

25. Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study

Author

Piero Ruscitti, Paola Cipriani, Vasiliki Liakouli, Daniela Iacono, Ilenia Pantano, Domenico Paolo Emanuele Margiotta, Luca Navarini, Giulia Maria Destro Castaniti, Nicola Maruotti, Gerardo Di Scala, Francesco Caso, Sara Bongiovanni, Rosa Daniela Grembiale, Fabiola Atzeni, Raffaele Scarpa, Federico Perosa, Giacomo Emmi, Francesco Paolo Cantatore, Giuliana Guggino, Antonella Afeltra, Francesco Ciccia, Roberto Giacomelli, Ruscitti, Piero, Cipriani, Paola, Liakouli, Vasiliki, Iacono, Daniela, Pantano, Ilenia, Margiotta, Domenico Paolo Emanuele, Navarini, Luca, Destro Castaniti, Giulia Maria, Maruotti, Nicola, Di Scala, Gerardo, Caso, Francesco, Bongiovanni, Sara, Grembiale, Rosa Daniela, Atzeni, Fabiola, Scarpa, Raffaele, Perosa, Federico, Emmi, Giacomo, Cantatore, Francesco Paolo, Guggino, Giuliana, Afeltra, Antonella, Ciccia, Francesco, and Giacomelli, Roberto

Subjects
Metabolic Syndrome, Arthritis, Immunology, Arthritis, Rheumatoid, Diabetes Mellitus, Type 2, Rheumatology, Risk Factors, Rheumatoid, Hypertension, Diabetes Mellitus, Immunology and Allergy, Humans, Prospective Studies, Type 2
Abstract

Objectives: In rheumatoid arthritis (RA), "traditional" cardiovascular (CV) risk factors continue to be underdiagnosed and undertreated, thus increasing the risk of developing atherosclerosis. In this work, we evaluated the occurrence and predictive factors of "traditional" cardiovascular risk factors, with a focus on high blood pressure (HBP), type 2 diabetes (T2D), and metabolic syndrome (MetS), in participants with RA, in a 3-year, multicentre, prospective, observational study. Methods: To assess the occurrence and predictive factors of HBP, T2D, and MetS, consecutive participants with RA, admitted to Italian Rheumatology Units, were evaluated in the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) cohort, a 3-year, multicentre, prospective, observational study. Results: In the present evaluation, 841 participants, who were fully followed up with 3-year of prospective follow-up were assessed. At the end of follow-up, a significant increased incidence of HBP, T2D, and MetS was recorded. Assessing predictive factors, the mean values of C-reactive protein during the follow-up were independent predictors of occurrence of those comorbidities, whereas participants maintaining remission showed a significant lower risk. Furthermore, therapy with hydroxychloroquine (HCQ) reduced the risk of occurrence of T2D and MetS. Conclusions: An increased incidence of HBP, T2D, and MetS was observed in assessed participants, prospectively followed-up. Furthermore, the analysis of predictive factors suggested that the rheumatoid pro-inflammatory process could increase the occurrence of these comorbidities. Conversely, metabolic and cardiovascular benefits of maintaining remission as well as of therapy with HCQ were reported.

26. Central sensitivity in fibromyalgia: testing a model to explain the role of psychological factors on functioning and quality of life.

Author

Nimbi FM, Renzi A, Limoncin E, Bongiovanni SF, Sarzi-Puttini P, and Galli F

Subjects
Humans, Female, Middle Aged, Adult, Central Nervous System Sensitization, Models, Psychological, Pain Threshold psychology, Personality, Temperament, Chronic Pain psychology, Chronic Pain physiopathology, Chronic Pain diagnosis, Fibromyalgia psychology, Fibromyalgia physiopathology, Fibromyalgia diagnosis, Quality of Life
Abstract

Objectives: Central sensitivity (CS) is defined as an increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold inputs. CS has recently been linked to the psychological burden associated with chronic pain, such as fibromyalgia (FM). The primary objective of this study is to investigate the impact of specific psychological constructs on CS in patients with FM. In Study 1, we explore the influence of temperament, personality, childhood trauma, defence mechanisms, and mental pain on CS. In Study 2, our goal is to test the role of the best predictors of CS in influencing quality of life (QoL) and FM functioning through a path analysis model., Methods: A total of 510 women with FM participated online, completing a self-administered protocol. Data collection took place between April and June of 2023., Results: In Study 1, higher levels of low sensory threshold (β=0.210), traumatic experiences of physical threat (β=0.141), neurotic defences (β=0.124), and mental pain (β=0.241) emerged as the strongest predictors of increased CS. In Study 2, the presented model demonstrated a satisfactory fit (chi2=27.200; df=10; p=0.002; GFI=0.984; NFI=0.949; CFI=0.967; RMSEA=0.061 [95% CI 0.034-0.090]) with large and medium effect sizes on physical (-0.576) and psychological (-0.190) QoL., Conclusions: The study underscores the pivotal role of psychological dimensions in influencing CS levels and their relationships with QoL in patients with FM.

Published
2024
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27. Environmental factors and fibromyalgia syndrome: a narrative review.

Author

Bazzichi L, Giorgi V, Di Franco M, Iannuccelli C, Bongiovanni S, Batticciotto A, Pellegrino G, and Sarzi Puttini P

Subjects
Humans, Risk Factors, Environmental Exposure adverse effects, Stress, Psychological complications, Stress, Psychological psychology, Electromagnetic Fields adverse effects, Air Pollution adverse effects, Diet adverse effects, Fibromyalgia psychology, Fibromyalgia therapy, Fibromyalgia etiology, Fibromyalgia diagnosis, Fibromyalgia physiopathology
Abstract

This in-depth review of fibromyalgia (FM), which is a complex condition characterised by chronic pain, fatigue, sleep disturbances, and a spectrum of diagnostically and therapeutically challenging symptoms, underlines the need for a comprehensive and integrated approach that also takes into account the psychological factors affecting patient responses. We focus on the substantial impact that environmental factors (climatic variations, air pollution, electromagnetic field exposure, physical and emotional traumas, dietary patterns, and infections) have on the manifestation and intensity of symptoms, and advocate personalised, holistic treatment of patients' psychological and environmental sensitivities by suggesting the benefits of tailored dietary and stress management. We also call for further research into the complex interplay of environmental, biological and psychological factors influencing FM in order to develop more effective individualised treatments that are capable of enhancing patient care and outcomes.

Published
2024
Full Text
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28. Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study.

Author

Giorgi V, Bongiovanni S, Atzeni F, Marotto D, Salaffi F, and Sarzi-Puttini P

Subjects
Humans, Prospective Studies, Quality of Life, Surveys and Questionnaires, Analgesics therapeutic use, Fibromyalgia drug therapy, Medical Marijuana therapeutic use
Abstract

Objectives: To assess any clinical improvement attributable to the addition of medical cannabis treatment (MCT) to the stable (>3 months) standard analgesic treatment of fibromyalgia (FM) patients, the retention rate and any changes in the concomitant analgesic treatment over a period of six months., Methods: The study involved 102 consecutive FM patients with VAS scores ≥4 despite standard analgesic treatment. Patients were prescribed two oil-diluted cannabis extracts: Bedrocan (22% THC, <1% CBD), and Bediol (6.3% THC, 8% CBD). FM severity was periodically assessed using Fibromyalgia Impact Questionnaire (FIQR), Fibromyalgia Assessment Scale (FAS), FACIT-Fatigue score, Pittsburgh Sleep Quality Index (PSQI), and Zung Depression and Anxiety Scales. During the study, patients were allowed to reduce or stop their concomitant analgesic therapy., Results: The 6-month retention rate was 64%. A significant improvement in the PSQI and FIQR was observed in respectively 44% and 33% of patients. 50% showed a moderate improvement in the anxiety and depression scales. Multiple regression analysis showed a correlation between the body mass index (BMI) and FIQR improvement (p=0.017). Concomitant analgesic treatment was reduced or suspended in 47% of the patients. One-third experienced mild adverse events, which did not cause any significant treatment modifications., Conclusions: This observational study shows that adjunctive MCT offers a possible clinical advantage in FM patients, especially in those with sleep dysfunctions. The clinical improvement inversely correlated with BMI. The retention rate and changes in concomitant analgesic therapy reflect MCT efficacy of the improved quality of life of patients. Further studies are needed to confirm these data, identify MCT-responsive sub-groups of FM patients, and establish the most appropriate posology and duration of the therapy.

Published
2020

29. Evaluation of salivary and plasma microRNA expression in patients with Sjögren's syndrome, and correlations with clinical and ultrasonographic outcomes.

Author

Talotta R, Mercurio V, Bongiovanni S, Vittori C, Boccassini L, Rigamonti F, Batticciotto A, Atzeni F, Trabattoni D, Sarzi-Puttini P, and Biasin M

Subjects
Aged, Biomarkers, Female, Humans, Middle Aged, Salivary Glands, MicroRNAs metabolism, Sjogren's Syndrome diagnostic imaging, Sjogren's Syndrome metabolism, Ultrasonography
Abstract

Objectives: To correlate the expression of microRNAs (miRNAs) 146a/b, 16, the 17-92 cluster and 181a in salivary and plasma samples taken from primary Sjögren's syndrome (pSS) patients with clinical, laboratory and ultrasound findings., Methods: Plasma and salivary samples were collected from 28 patients with pSS according to 2012 ACR and/or 2016 ACR/EULAR criteria (27 females, mean age 64.4±10.1 years, mean disease duration 10.7±6.9 years), and from 23 healthy subjects used as controls. The following patient data were recorded: ESSDAI and ESSPRI scores, anti-SSA and anti-SSB antibody status and laboratory data, Schirmer's test, ultrasound scores of the four major salivary glands according to Cornec et al., and concomitant treatments. The retro-transcribed and quantified miRNAs were: miR16-5p, miR17-5p, miR18a-5p, miR19a-5p, miR19b-1-5p, miR20a, miR92-5p, miR146a-5p, miR146b-5p, miR181a-5p., Results: SS patients had higher expression of salivary miR146a than gender- and age-matched controls (p=0.01). Spearman's regression analysis revealed that salivary miR146b was significantly more expressed in the patients with worse ESSPRI scores (p=0.02), whereas salivary miR17 and 146b and plasma miR17 expression was lower in the patients with higher ultrasound scores (respectively p=0.01, p=0.01 and p=0.04). Salivary miR18a expression was significantly increased in the patients who were anti-La/SSB positive (p=0.04). Neither salivary nor plasma miRNAs correlated with disease duration or concomitant therapies., Conclusions: Our data show that salivary mi146a may represent a marker of the disease, and that the expression of salivary miR17, 18a and 146b may be altered in patients with pSS, and associated with worse ultrasound and ESSPRI scores and anti-La/SSB positivity.

Published
2019

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