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1. Mass accretion rates of clusters of galaxies: CIRS and HeCS

Author: Pizzardo, M., Di Gioia, S., Diaferio, A., De Boni, C., Serra, A. L., Geller, M. J., Sohn, J., Rines, K., and Baldi, M.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We use a new spherical accretion recipe tested on N-body simulations to measure the observed mass accretion rate (MAR) of 129 clusters in the Cluster Infall Regions in the Sloan Digital Sky Survey (CIRS) and in the Hectospec Cluster Survey (HeCS). The observed clusters cover the redshift range of $0.01
Published: 2020
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2. A LIKELY INTERSECTIONAL HYBRID IN VACCINIUM (ERICACEAE) ON SAN BRUNO MOUNTAIN, SAN MATEO COUNTY, CALIFORNIA

Author: Fritsch, Peter W, Simison, W. Brian, Cruz, Boni C, Schneider, Edward L, Allshouse, Douglas D, and BioStor
Published: 2021

3. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author: Kondili, L, Brancaccio, G, Tosti, M, Coco, B, Quaranta, M, Messina, V, Ciancio, A, Morisco, F, Cossiga, V, Claar, E, Rosato, V, Ciarallo, M, Cacciola, I, Ponziani, F, Cerrito, L, Coppola, R, Longobardi, F, Biliotti, E, Rianda, A, Barbaro, F, Coppola, N, Stanzione, M, Barchiesi, F, Fagiuoli, S, Vigano, M, Massari, M, Russo, F, Ferrarese, A, Laccabue, D, Di Marco, V, Blanc, P, Marrone, A, Morsica, G, Federico, A, Ieluzzi, D, Rocco, A, Foschi, F, Soria, A, Maida, I, Chessa, L, Milella, M, Rosselli Del Turco, E, Madonia, S, Chemello, L, Gentile, I, Toniutto, P, Bassetti, M, Surace, L, Baiocchi, L, Pellicelli, A, De Santis, A, Puoti, M, Degasperi, E, Niro, G, Zignego, A, Craxi, A, Raimondo, G, Santantonio, T, Brunetto, M, Gaeta, G, Aghemo, A, Baiguera, C, Battezzati, P, Battistella, S, Bavetta, M, Bertoni, C, Boni, C, Brambilla, P, Bray, A, Briano, F, Carmenini, E, Castelli, F, Cavalletto, L, Cerini, F, Chidichimo, L, Colella, E, Cologni, G, Como, S, Corsini, R, Costa, C, Cotugno, R, Cretella, S, De Angelis, F, De Leo, P, Perri, G, Falbo, E, Ferrigno, L, Fornasiere, E, Francisci, D, Gatti, P, Lampertico, P, Lenci, I, Licata, A, Marzano, A, Mastroianni, A, Mazzaro, C, Monti, M, Nardone, G, Nicolini, L, Passigato, N, Pasticci, M, Pierotti, P, Pinchera, B, Pollicino, T, Porcu, C, Quartini, G, Rancatore, G, Romeo, M, Rumi, M, Saracino, A, Schioppa, O, Serio, I, Soffredini, R, Tata, X, Tizzani, M, Tonnini, M, Torti, C, Valenti, D, Zaltron, S, Zoncada, A, Kondili L. A., Brancaccio G., Tosti M. E., Coco B., Quaranta M. G., Messina V., Ciancio A., Morisco F., Cossiga V., Claar E., Rosato V., Ciarallo M., Cacciola I., Ponziani F. R., Cerrito L., Coppola R., Longobardi F., Biliotti E., Rianda A., Barbaro F., Coppola N., Stanzione M., Barchiesi F., Fagiuoli S., Vigano M., Massari M., Russo F. P., Ferrarese A., Laccabue D., Di Marco V., Blanc P., Marrone A., Morsica G., Federico A., Ieluzzi D., Rocco A., Foschi F. G., Soria A., Maida I., Chessa L., Milella M., Rosselli Del Turco E., Madonia S., Chemello L., Gentile I., Toniutto P., Bassetti M., Surace L., Baiocchi L., Pellicelli A., De Santis A., Puoti M., Degasperi E., Niro G. A., Zignego A. L., Craxi A., Raimondo G., Santantonio T. A., Brunetto M. R., Gaeta G. B., Aghemo A., Baiguera C., Battezzati P. M., Battistella S., Bavetta M. G., Bertoni C., Boni C., Brambilla P., Bray A., Briano F., Carmenini E., Castelli F., Cavalletto L., Cerini F., Chidichimo L., Colella E., Cologni G., Como S., Corsini R., Costa C., Cotugno R., Cretella S., De Angelis F., De Leo P., Perri G. D., Falbo E., Ferrigno L., Fornasiere E., Francisci D., Gatti P., Lampertico P., Lenci I., Licata A., Marzano A., Mastroianni A., Mazzaro C., Monti M., Nardone G., Nicolini L. A., Passigato N., Pasticci M. B., Pierotti P., Pinchera B., Pollicino T., Porcu C., Quartini G., Rancatore G., Romeo M., Rumi M. G., Saracino A., Schioppa O., Serio I., Soffredini R., Tata X., Tizzani M., Tonnini M., Torti C., Valenti D., Zaltron S., Zoncada A., Kondili, L, Brancaccio, G, Tosti, M, Coco, B, Quaranta, M, Messina, V, Ciancio, A, Morisco, F, Cossiga, V, Claar, E, Rosato, V, Ciarallo, M, Cacciola, I, Ponziani, F, Cerrito, L, Coppola, R, Longobardi, F, Biliotti, E, Rianda, A, Barbaro, F, Coppola, N, Stanzione, M, Barchiesi, F, Fagiuoli, S, Vigano, M, Massari, M, Russo, F, Ferrarese, A, Laccabue, D, Di Marco, V, Blanc, P, Marrone, A, Morsica, G, Federico, A, Ieluzzi, D, Rocco, A, Foschi, F, Soria, A, Maida, I, Chessa, L, Milella, M, Rosselli Del Turco, E, Madonia, S, Chemello, L, Gentile, I, Toniutto, P, Bassetti, M, Surace, L, Baiocchi, L, Pellicelli, A, De Santis, A, Puoti, M, Degasperi, E, Niro, G, Zignego, A, Craxi, A, Raimondo, G, Santantonio, T, Brunetto, M, Gaeta, G, Aghemo, A, Baiguera, C, Battezzati, P, Battistella, S, Bavetta, M, Bertoni, C, Boni, C, Brambilla, P, Bray, A, Briano, F, Carmenini, E, Castelli, F, Cavalletto, L, Cerini, F, Chidichimo, L, Colella, E, Cologni, G, Como, S, Corsini, R, Costa, C, Cotugno, R, Cretella, S, De Angelis, F, De Leo, P, Perri, G, Falbo, E, Ferrigno, L, Fornasiere, E, Francisci, D, Gatti, P, Lampertico, P, Lenci, I, Licata, A, Marzano, A, Mastroianni, A, Mazzaro, C, Monti, M, Nardone, G, Nicolini, L, Passigato, N, Pasticci, M, Pierotti, P, Pinchera, B, Pollicino, T, Porcu, C, Quartini, G, Rancatore, G, Romeo, M, Rumi, M, Saracino, A, Schioppa, O, Serio, I, Soffredini, R, Tata, X, Tizzani, M, Tonnini, M, Torti, C, Valenti, D, Zaltron, S, Zoncada, A, Kondili L. A., Brancaccio G., Tosti M. E., Coco B., Quaranta M. G., Messina V., Ciancio A., Morisco F., Cossiga V., Claar E., Rosato V., Ciarallo M., Cacciola I., Ponziani F. R., Cerrito L., Coppola R., Longobardi F., Biliotti E., Rianda A., Barbaro F., Coppola N., Stanzione M., Barchiesi F., Fagiuoli S., Vigano M., Massari M., Russo F. P., Ferrarese A., Laccabue D., Di Marco V., Blanc P., Marrone A., Morsica G., Federico A., Ieluzzi D., Rocco A., Foschi F. G., Soria A., Maida I., Chessa L., Milella M., Rosselli Del Turco E., Madonia S., Chemello L., Gentile I., Toniutto P., Bassetti M., Surace L., Baiocchi L., Pellicelli A., De Santis A., Puoti M., Degasperi E., Niro G. A., Zignego A. L., Craxi A., Raimondo G., Santantonio T. A., Brunetto M. R., Gaeta G. B., Aghemo A., Baiguera C., Battezzati P. M., Battistella S., Bavetta M. G., Bertoni C., Boni C., Brambilla P., Bray A., Briano F., Carmenini E., Castelli F., Cavalletto L., Cerini F., Chidichimo L., Colella E., Cologni G., Como S., Corsini R., Costa C., Cotugno R., Cretella S., De Angelis F., De Leo P., Perri G. D., Falbo E., Ferrigno L., Fornasiere E., Francisci D., Gatti P., Lampertico P., Lenci I., Licata A., Marzano A., Mastroianni A., Mazzaro C., Monti M., Nardone G., Nicolini L. A., Passigato N., Pasticci M. B., Pierotti P., Pinchera B., Pollicino T., Porcu C., Quartini G., Rancatore G., Romeo M., Rumi M. G., Saracino A., Schioppa O., Serio I., Soffredini R., Tata X., Tizzani M., Tonnini M., Torti C., Valenti D., Zaltron S., and Zoncada A.
Abstract: Background and Aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. Results: Of 5492 HBsAg-positive enrolled patients, 4152 (75.6%) were screened for HDV, 422 (10.2%) were anti-HDV positive. Compared with HBsAg mono-infected, anti-HDV positive patients were more often younger, non-Italians, with a history of drug use, had elevated alanine transaminase (ALT), cirrhosis, or hepatocellular carcinoma (HCC). Compared with Italians, anti-HDV positive non-Italians were younger (42.2% age ≤ 40 years vs. 2.1%; P < 0.001), more often females (males 43.0% vs. 68.6%; P < 0.001) with less frequent cirrhosis and HCC. HDV-RNA was detected in 63.2% of anti-HDV-positive patients, who were more likely to have elevated ALT, cirrhosis, and HCC. Extrahepatic comorbidities were present in 47.4% of anti-HDV positive patients and could affect the eligibility of IFN-containing therapies in at least 53.0% of patients in care. Conclusions: CHD affects young, foreign-born patients and older Italians, of whom two-thirds had cirrhosis or HCC. Comorbidities were frequent in both Italians and non-Italians and impacted eligibility for IFN.
Published: 2024

4. Ecological and social factors influence interspecific pathogens occurrence among bees

Author: Tiritelli, R, Flaminio, S, Zavatta, L, Ranalli, R, Giovanetti, M, Grasso, D, Leonardi, S, Bonforte, M, Boni, C, Cargnus, E, Catania, R, Coppola, F, Di Santo, M, Pusceddu, M, Quaranta, M, Bortolotti, L, Nanetti, A, Cilia, G, Tiritelli R., Flaminio S., Zavatta L., Ranalli R., Giovanetti M., Grasso D. A., Leonardi S., Bonforte M., Boni C. B., Cargnus E., Catania R., Coppola F., Di Santo M., Pusceddu M., Quaranta M., Bortolotti L., Nanetti A., Cilia G., Tiritelli, R, Flaminio, S, Zavatta, L, Ranalli, R, Giovanetti, M, Grasso, D, Leonardi, S, Bonforte, M, Boni, C, Cargnus, E, Catania, R, Coppola, F, Di Santo, M, Pusceddu, M, Quaranta, M, Bortolotti, L, Nanetti, A, Cilia, G, Tiritelli R., Flaminio S., Zavatta L., Ranalli R., Giovanetti M., Grasso D. A., Leonardi S., Bonforte M., Boni C. B., Cargnus E., Catania R., Coppola F., Di Santo M., Pusceddu M., Quaranta M., Bortolotti L., Nanetti A., and Cilia G.
Abstract: The interspecific transmission of pathogens can occur frequently in the environment. Among wild bees, the main spillover cases are caused by pathogens associated with Apis mellifera, whose colonies can act as reservoirs. Due to the limited availability of data in Italy, it is challenging to accurately assess the impact and implications of this phenomenon on the wild bee populations. In this study, a total of 3372 bees were sampled from 11 Italian regions within the BeeNet project, evaluating the prevalence and the abundance of the major honey bee pathogens (DWV, BQCV, ABPV, CBPV, KBV, Nosema ceranae, Ascosphaera apis, Crithidia mellificae, Lotmaria passim, Crithidia bombi). The 68.4% of samples were positive for at least one pathogen. DWV, BQCV, N. ceranae and CBPV showed the highest prevalence and abundance values, confirming them as the most prevalent pathogens spread in the environment. For these pathogens, Andrena, Bombus, Eucera and Seladonia showed the highest mean prevalence and abundance values. Generally, time trends showed a prevalence and abundance decrease from April to July. In order to predict the risk of infection among wild bees, statistical models were developed. A low influence of apiary density on pathogen occurrence was observed, while meteorological conditions and agricultural management showed a greater impact on pathogen persistence in the environment. Social and biological traits of wild bees also contributed to defining a higher risk of infection for bivoltine, communal, mining and oligolectic bees. Out of all the samples tested, 40.5% were co-infected with two or more pathogens. In some cases, individuals were simultaneously infected with up to five different pathogens. It is essential to increase knowledge about the transmission of pathogens among wild bees to understand dynamics, impact and effects on pollinator populations. Implementing concrete plans for the conservation of wild bee species is important to ensure the health of wild and
Published: 2024

5. A LIKELY INTERSECTIONAL HYBRID IN VACCINIUM (ERICACEAE) ON SAN BRUNO MOUNTAIN, SAN MATEO COUNTY, CALIFORNIA

Author: Fritsch, Peter W., Simison, W. Brian, Cruz, Boni C., Schneider, Edward L., and Allshouse, Douglas D.
Published: 2020

6. A genome-wide association study of anorexia nervosa

Author: Boraska, V, Franklin, CS, Floyd, JAB, Thornton, LM, Huckins, LM, Southam, L, Rayner, NW, Tachmazidou, I, Klump, KL, Treasure, J, Lewis, CM, Schmidt, U, Tozzi, F, Kiezebrink, K, Hebebrand, J, Gorwood, P, Adan, RAH, Kas, MJH, Favaro, A, Santonastaso, P, Fernández-Aranda, F, Gratacos, M, Rybakowski, F, Dmitrzak-Weglarz, M, Kaprio, J, Keski-Rahkonen, A, Raevuori, A, Van Furth, EF, Slof-Op 't Landt, MCT, Hudson, JI, Reichborn-Kjennerud, T, Knudsen, GPS, Monteleone, P, Kaplan, AS, Karwautz, A, Hakonarson, H, Berrettini, WH, Guo, Y, Li, D, Schork, NJ, Komaki, G, Ando, T, Inoko, H, Esko, T, Fischer, K, Männik, K, Metspalu, A, Baker, JH, Cone, RD, Dackor, J, DeSocio, JE, Hilliard, CE, O'Toole, JK, Pantel, J, Szatkiewicz, JP, Taico, C, Zerwas, S, Trace, SE, Davis, OSP, Helder, S, Bühren, K, Burghardt, R, de Zwaan, M, Egberts, K, Ehrlich, S, Herpertz-Dahlmann, B, Herzog, W, Imgart, H, Scherag, A, Scherag, S, Zipfel, S, Boni, C, Ramoz, N, Versini, A, Brandys, MK, Danner, UN, de Kovel, C, Hendriks, J, Koeleman, BPC, Ophoff, RA, Strengman, E, van Elburg, AA, Bruson, A, Clementi, M, Degortes, D, Forzan, M, Tenconi, E, Docampo, E, Escaramís, G, Jiménez-Murcia, S, Lissowska, J, Rajewski, A, Szeszenia-Dabrowska, N, Slopien, A, Hauser, J, Karhunen, L, Meulenbelt, I, Slagboom, PE, Tortorella, A, and Maj, M
Subjects: Anorexia, Mental Health, Serious Mental Illness, Human Genome, Eating Disorders, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Anorexia Nervosa, Asian People, Calcineurin, Carrier Proteins, Case-Control Studies, Cullin Proteins, Female, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Humans, Japan, Male, Meta-Analysis as Topic, Nuclear Proteins, Polymorphism, Single Nucleotide, White People, anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic, Wellcome Trust Case Control Consortium 3, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
Published: 2014

7. The relative concentration of visible and dark matter in clusters of galaxies

Author: De Boni, C. and Bertin, G.
Subjects: Astrophysics
Abstract: [Abridged] We consider two clusters (A496 and Coma) that are representative of the two classes of cool-core and non-cool-core clusters. We first refer to a two-component dynamical model that ignores the contribution from the galaxy density distribution and study the condition of hydrostatic equilibrium for the hot intracluster medium (ICM) under the assumption of spherical symmetry, in the presence of dark matter. We model the ICM density distribution in terms of a standard $\beta$-model with $\beta=2/3$, i.e. with a distribution similar to that of a regular isothermal sphere (RIS), and fit the observed X-ray brightness profiles. With the explicit purpose of ignoring cosmological arguments, we na\"ively assume that dark matter, if present, has an analogous density distribution, with the freedom of two different density and length scales. The relative distribution of visible and dark matter is then derived by fitting the temperature data for the ICM under conditions of hydrostatic equilibrium. For both clusters, we find that dark matter is more concentrated with respect to visible matter. We then test whether the conclusion changes significantly when dark matter is taken to be distributed according to cosmologically favored density profiles and when the contribution of the mass contained in galaxies is taken into account. Although the qualitative conclusions remain unchanged, we find that the contribution of galaxies to the mass budget is more important than generally assumed. We also show that, without resorting to additional information on the small scale, it is not possible to tell whether a density cusp is present or absent in these systems. [Abridged], Comment: 13 pages, 3 figures, accepted for publication in Il Nuovo Cimento B
Published: 2008
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8. Leaf adaptations and species boundaries in North American Cercis : implications for the evolution of dry floras

Author: Fritsch, Peter W., Nowell, Camille F., Leatherman, Lila S.T., Gong, Wei, Cruz, Boni C., Burge, Dylan O., and Delgado-Salinas, Alfonso
Published: 2018

9. Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

Author: de Gramont, A., primary, Figer, A., additional, Seymour, M., additional, Homerin, M., additional, Hmissi, A., additional, Cassidy, J., additional, Boni, C., additional, Cortes-Funes, H., additional, Cervantes, A., additional, Freyer, G., additional, Papamichael, D., additional, Le Bail, N., additional, Louvet, C., additional, Hendler, D., additional, de Braud, F., additional, Wilson, C., additional, Morvan, F., additional, and Bonetti, A., additional
Published: 2023
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10. 192 Unraveling the dark side of cystic fibrosis inflammation: cellular senescence

Author: Bezzerri, V., primary, Boni, C., additional, Baldisseri, E., additional, Borgatti, M., additional, Vella, A., additional, Olioso, D., additional, Quiri, F., additional, Lippi, G., additional, Gunawardena, T., additional, Moraes, T., additional, and Cipolli, M., additional
Published: 2023
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11. Prise en charge des exacerbations d’asthme chez l’enfant aux urgences du CHU d’Angré à Abidjan

Author: Cardenat, M., Amon Tanoh Dick, F., Azagoh-Kouadio, R., Dje, A.S., and Zallo-Boni, C.
Published: 2024
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12. Metabolic dysfunction and DNA damage of exhausted tumor-infiltrating CD8 T-cells in hepatocellular carcinoma

Author: Montali, A., primary, Reverberi, V., additional, Dalla Valle, R., additional, Boni, C., additional, Fisicaro, P., additional, Vecchi, A., additional, Rossi, M., additional, Doselli, S., additional, Berti, C. Ceccatelli, additional, Tiezzi, C., additional, Montali, I., additional, Ferrari, C., additional, and Missale, G., additional
Published: 2023
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13. PERKINSIODENDRON, A NEW GENUS IN THE STYRACACEAE BASED ON MORPHOLOGY AND DNA SEQUENCES

Author: Fritsch, Peter W., Yao, Xiaohong, Simison, W. Brian, Cruz, Boni C., and Chen, Tao
Published: 2016

14. Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial

Author: Masi, G., Salvatore, L., Boni, L., Loupakis, F., Cremolini, C., Fornaro, L., Schirripa, M., Cupini, S., Barbara, C., Safina, V., Granetto, C., Fea, E., Antonuzzo, L., Boni, C., Allegrini, G., Chiara, S., Amoroso, D., Bonetti, A., and Falcone, A.
Published: 2015
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15. Early Phylogenetic Divergence of Gynodioecious Species Warrants the Recognition of Subseries in Styrax Series Valvatae

Author: Fritsch, Peter W., Cruz, Boni C., Simison, W. Brian, Campbell, Alexandra J., and Harris, Jennifer K.
Published: 2015

16. Northern Hemisphere origins of the amphi-Pacific tropical plant family Symplocaceae

Author: Fritsch, Peter W., Manchester, Steven R., Stone, R. Douglas, Cruz, Boni C., and Almeda, Frank
Published: 2015

17. Docetaxel plus oxaliplatin with or without fluorouracil or capecitabine in metastatic or locally recurrent gastric cancer: a randomized phase II study

Author: Van Cutsem, E., Boni, C., Tabernero, J., Massuti, B., Middleton, G., Dane, F., Reichardt, P., Pimentel, F.L., Cohn, A., Follana, P., Clemens, M., Zaniboni, A., Moiseyenko, V., Harrison, M., Richards, D.A., Prenen, H., Pernot, S., Ecstein-Fraisse, E., Hitier, S., and Rougier, P.
Published: 2015
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18. Metabolic and Functional Characterization of CD8+ T-Cell Subpopulations in Hepatocellular Carcinoma: Implications of Tumor Microenvironment on T-Cell Dysfunction.

Author: Montali, A., Reverberi, V., Pelagatti, A., Vecchi, A., Rossi, M., Doselli, S., Farina, B., Olivani, A., Economopoulos, G., Valle, R. Dalla, Fisicaro, P., Boni, C., and Missale, G.
Abstract: CD8 T-cells are crucial in adaptive immune response, against viral infections and tumors. The tumor immune microenvironment (TIME) can disrupt immunological pathways. In hepatocellular carcinoma, CD8 T-cell functional defects correlate with disease stage and clinical outcomes, but the molecular bases of their dysfunction are not fully understood. This study aims to characterize metabolic and functional differences between tumor-infiltrating and liver-infiltrating CD8+ T-cell subpopulations. We performed phenotypic expression of surface markers (CD103, CD39 and PD1) that can define CD8 subsets: Tissue resident memory (TRM), Tumor reactive (Tr) and Terminally exhausted cells (TEX). By analyzing metabolic status, DNA damage response, and cytokine production, we seek to elucidate TIME's impact on T-cell functionality. The tumor microenvironment was enriched of TEX cells (CD39+ CD103- PD1+) and Tr cells (CD39+/CD103+) compared to the surrounding liver. Moreover, PD1 and Tim3 co-expression was significantly enriched in all subsets from the tumor as well as frequency of PD1hi CD8 T-cells. Metabolic analyses revealed that tumor-infiltrating subpopulations had lower glucose uptake and higher mitochondrial membrane depolarization, indicating significant metabolic strain, and higher histone H2AX phosphorylation, indicating more DNA damage. TEX showed highest H2AX phosphorylation, while TRM the lowest. In tumor-infiltrating CD8+ T-cells, mitochondrial membrane depolarization correlated positively with p-H2AX+ cells and negatively with glucose uptake. Functional analysis revealed an overall lack of functionality in tumor-infiltrating TEX cells. Finally, patients with larger tumor nodules showed an enrichment of TEX cells and reduction of Tumor-reactive and TRM cells. The TIME imposes significant metabolic and DNA damage stress on CD8+ T-cell subpopulations, leading to functional impairments. Therapeutic strategies targeting these metabolic challenges are essential for enhancing anti-tumor immunity. [ABSTRACT FROM AUTHOR]
Published: 2025
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19. Flexural tensegrity: Field applications

Author: Boni, C., primary
Published: 2023
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20. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author: Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Mangano, S., Tonato, M., Zucca, E., Valsecchi, M.G., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., Dell'Oro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.
Published: 2014
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21. 688 Lipid-based therapeutic strategies in addition to cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis treatment

Author: Boni, C., primary, Loberto, N., additional, Dobi, D., additional, Bassi, R., additional, Mauri, L., additional, Olioso, D., additional, Bezzerri, V., additional, Onorato, D., additional, Polimeni, A., additional, Cabrini, G., additional, Lippi, G., additional, Pedemonte, N., additional, Tamanini, A., additional, and Aureli, M., additional
Published: 2022
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22. 509 Cystic fibrosis transmembrane conductance regulator positively regulates angiotensin-converting enzyme 2 expression and SARS-CoV-2 viral entry into airway epithelial cells: Implications for patients with cystic fibrosis

Author: Bezzerri, V., primary, Gentili, V., additional, Boni, C., additional, Baldisseri, E., additional, Finotti, A., additional, Papi, C., additional, Tamanini, A., additional, Olioso, D., additional, Polimeni, A., additional, Leo, S., additional, Borgatti, M., additional, Volpi, S., additional, Pinton, P., additional, Cabrini, G., additional, Gambari, R., additional, Blasi, F., additional, Lippi, G., additional, Rimessi, A., additional, Rizzo, R., additional, and Cipolli, M., additional
Published: 2022
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23. Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma: a prospective feasibility analysis

Author: Pressiani, T., Boni, C., Rimassa, L., Labianca, R., Fagiuoli, S., Salvagni, S., Ferrari, D., Cortesi, E., Porta, C., Mucciarini, C., Latini, L., Carnaghi, C., Banzi, M., Fanello, S., De Giorgio, M., Lutman, F.R., Torzilli, G., Tommasini, M.A., Ceriani, R., Covini, G., Tronconi, M.C., Giordano, L., Locopo, N., Naimo, S., and Santoro, A.
Published: 2013
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24. Ultrasound and Fetal Stress: Study of the Fetal Blink-Startle Reflex Evoked by Acoustic Stimuli

Author: Bocchi, C., Severi, F. M., Bruni, L., Filardi, G., Delia, A., Boni, C., Altomare, A., Bellieni, C. V., Petraglia, F., Buonocore, Giuseppe, editor, and Bellieni, Carlo V., editor
Published: 2008
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25. Phylogeny of Cercis based on DNA sequences of nuclear ITS and four plastid regions: Implications for transatlantic historical biogeography

Author: Fritsch, Peter W. and Cruz, Boni C.
Published: 2012
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26. Phylogenetic Analysis of the Wintergreen Group (Ericaceae) based on Six Genie Regions

Author: Fritsch, Peter W., Lu, Lu, Bush, Catherine M., Cruz, Boni C., Kron, Kathleen A., and Li, De-Zhu
Published: 2011
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27. Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections

Author: Ferrari, C., Penna, A., Bertoletti, A., Cavalli, A., Missale, G., Lamonaca, V., Boni, C., Valli, A., Bertoni, R., Urbani, S., Scognamiglio, P., Fiaccadori, F., Schlag, P. M., editor, Senn, H.-J., editor, Diehl, V., editor, Parkin, D. M., editor, Rajewsky, M. F., editor, Rubens, R., editor, Wannenmacher, M., editor, Schwab, Manfred, editor, Rabes, Hartmut M., editor, Munk, Klaus, editor, and Hofschneider, Hans Peter, editor
Published: 1998
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28. Hybridization between two oil-secreting orchids in South Africa

Author: Steiner, Kim E. and Cruz, Boni C.
Published: 2009

29. Common Genetic Variation and Age of Onset of Anorexia Nervosa

Author: Watson, H.J. Thornton, L.M. Yilmaz, Z. Baker, J.H. Coleman, J.R.I. Adan, R.A.H. Alfredsson, L. Andreassen, O.A. Ask, H. Berrettini, W.H. Boehnke, M. Boehm, I. Boni, C. Buehren, K. Bulant, J. Burghardt, R. Chang, X. Cichon, S. Cone, R.D. Courtet, P. Crow, S. Crowley, J.J. Danner, U.N. de Zwaan, M. Dedoussis, G. DeSocio, J.E. Dick, D.M. Dikeos, D. Dina, C. Djurovic, S. Dmitrzak-Weglarz, M. Docampo-Martinez, E. Duriez, P. Egberts, K. Ehrlich, S. Eriksson, J.G. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Fernández-Aranda, F. Fichter, M.M. Föcker, M. Foretova, L. Forstner, A.J. Frei, O. Gallinger, S. Giegling, I. Giuranna, J. Gonidakis, F. Gorwood, P. Gratacòs, M. Guillaume, S. Guo, Y. Hakonarson, H. Hauser, J. Havdahl, A. Hebebrand, J. Helder, S.G. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Hinney, A. Hübel, C. Hudson, J.I. Imgart, H. Jamain, S. Janout, V. Jiménez-Murcia, S. Jones, I.R. Julià, A. Kalsi, G. Kaminská, D. Kaprio, J. Karhunen, L. Kas, M.J.H. Keel, P.K. Kennedy, J.L. Keski-Rahkonen, A. Kiezebrink, K. Klareskog, L. Klump, K.L. Knudsen, G.P.S. La Via, M.C. Le Hellard, S. Leboyer, M. Li, D. Lilenfeld, L. Lin, B. Lissowska, J. Luykx, J. Magistretti, P. Maj, M. Marsal, S. Marshall, C.R. Mattingsdal, M. Meulenbelt, I. Micali, N. Mitchell, K.S. Monteleone, A.M. Monteleone, P. Myers, R. Navratilova, M. Ntalla, I. O'Toole, J.K. Ophoff, R.A. Padyukov, L. Pantel, J. Papežová, H. Pinto, D. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ripke, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Scherag, A. Scherer, S.W. Schmidt, U. Scott, L.J. Seitz, J. Silén, Y. Šlachtová, L. Slagboom, P.E. Slof-Op ‘t Landt, M.C.T. Slopien, A. Sorbi, S. Świątkowska, B. Tortorella, A. Tozzi, F. Treasure, J. Tsitsika, A. Tyszkiewicz-Nwafor, M. Tziouvas, K. van Elburg, A.A. van Furth, E.F. Walton, E. Widen, E. Zerwas, S. Zipfel, S. Bergen, A.W. Boden, J.M. Brandt, H. Crawford, S. Halmi, K.A. Horwood, L.J. Johnson, C. Kaplan, A.S. Kaye, W.H. Mitc and Watson, H.J. Thornton, L.M. Yilmaz, Z. Baker, J.H. Coleman, J.R.I. Adan, R.A.H. Alfredsson, L. Andreassen, O.A. Ask, H. Berrettini, W.H. Boehnke, M. Boehm, I. Boni, C. Buehren, K. Bulant, J. Burghardt, R. Chang, X. Cichon, S. Cone, R.D. Courtet, P. Crow, S. Crowley, J.J. Danner, U.N. de Zwaan, M. Dedoussis, G. DeSocio, J.E. Dick, D.M. Dikeos, D. Dina, C. Djurovic, S. Dmitrzak-Weglarz, M. Docampo-Martinez, E. Duriez, P. Egberts, K. Ehrlich, S. Eriksson, J.G. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Fernández-Aranda, F. Fichter, M.M. Föcker, M. Foretova, L. Forstner, A.J. Frei, O. Gallinger, S. Giegling, I. Giuranna, J. Gonidakis, F. Gorwood, P. Gratacòs, M. Guillaume, S. Guo, Y. Hakonarson, H. Hauser, J. Havdahl, A. Hebebrand, J. Helder, S.G. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Hinney, A. Hübel, C. Hudson, J.I. Imgart, H. Jamain, S. Janout, V. Jiménez-Murcia, S. Jones, I.R. Julià, A. Kalsi, G. Kaminská, D. Kaprio, J. Karhunen, L. Kas, M.J.H. Keel, P.K. Kennedy, J.L. Keski-Rahkonen, A. Kiezebrink, K. Klareskog, L. Klump, K.L. Knudsen, G.P.S. La Via, M.C. Le Hellard, S. Leboyer, M. Li, D. Lilenfeld, L. Lin, B. Lissowska, J. Luykx, J. Magistretti, P. Maj, M. Marsal, S. Marshall, C.R. Mattingsdal, M. Meulenbelt, I. Micali, N. Mitchell, K.S. Monteleone, A.M. Monteleone, P. Myers, R. Navratilova, M. Ntalla, I. O'Toole, J.K. Ophoff, R.A. Padyukov, L. Pantel, J. Papežová, H. Pinto, D. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ripke, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Scherag, A. Scherer, S.W. Schmidt, U. Scott, L.J. Seitz, J. Silén, Y. Šlachtová, L. Slagboom, P.E. Slof-Op ‘t Landt, M.C.T. Slopien, A. Sorbi, S. Świątkowska, B. Tortorella, A. Tozzi, F. Treasure, J. Tsitsika, A. Tyszkiewicz-Nwafor, M. Tziouvas, K. van Elburg, A.A. van Furth, E.F. Walton, E. Widen, E. Zerwas, S. Zipfel, S. Bergen, A.W. Boden, J.M. Brandt, H. Crawford, S. Halmi, K.A. Horwood, L.J. Johnson, C. Kaplan, A.S. Kaye, W.H. Mitc
Abstract: Background: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche. Methods: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (<13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism–h2) were 0.01–0.04 for age of onset, 0.16–0.25 for early-onset AN, and 0.17–0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction. © 2021 The Authors
Published: 2022

30. Phylogeny of Sinojackia (Styracaceae) Based on DNA Sequence and Microsatellite Data: Implications for Taxonomy and Conservation

Author: YAO, XIAOHONG, YE, QIGANG, FRITSCH, PETER W., CRUZ, BONI C., and HUANG, HONGWEN
Published: 2008

31. Cell-mediated Immune Response in Hepatitis C Virus (HCV) Infection: Are Different Strategies Adopted by HCV and Hepatitis B Virus to Persist?

Author: Fiaccadori, F., Missale, G., Lamonaca, V., Bertoni, R., Valli, A., Bertoletti, A., Boni, C., Cavalli, A., Penna, A., Ferrari, C., Gentilini, Paolo, editor, and Dianzani, Mario Umberto, editor
Published: 1996
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32. The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans

Author: Jyvakorpi S. K., Ramel A., Strandberg T. E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H. M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V. S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P. V., Marzetti E., Pitkala K. H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A. M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D. L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A. R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A. R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C. A., Gonzales Turin J., Zafra O. L. L., Picazo A. L., Sepulveda L. P., SanchezSanchez J. L., Puelles C. S., Aragones M. V., CruzJentoft A. J., Santos J. A., Alvarez-Nebreda L., JimenezJimenez N. F., Nozal J. M. -D., Montero-Errasquin B., Moreno B. P. B. P., Roldan-Plaza C., Vicente A. R. -D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M. N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J. J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P. P., Sieber C. C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S. D., Ebner N., Grutz R., von Haehling S., Schols A. M. W. J., Gosker H., Huysmans S., Quaaden S., Schols J. M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A. -M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G. A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P. -J., Teguo M. T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T. B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R. L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A. C., Yuan J., Roubenoff R., Kortebein P., Miller R. R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I. M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S. D., Feletti L., Marchioro E., Mocci F., Varesio M. G., Cesario A., Cabin B., de Boer W. P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A. -M., Mokhtari H., Rodon N., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Handicap, Activité, Vieillissement, Autonomie, Environnement (HAVAE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Clinicum, Department of General Practice and Primary Health Care, University of Helsinki, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Helsinki University Hospital Area, Teachers' Academy, Jyvakorpi S.K., Ramel A., Strandberg T.E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H.M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V.S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P.V., Marzetti E., Pitkala K.H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A.M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D.L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A.R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A.R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C.A., Gonzales Turin J., Zafra O.L.L., Picazo A.L., Sepulveda L.P., SanchezSanchez J.L., Puelles C.S., Aragones M.V., CruzJentoft A.J., Santos J.A., Alvarez-Nebreda L., JimenezJimenez N.F., Nozal J.M.-D., Montero-Errasquin B., Moreno B.P.B.P., Roldan-Plaza C., Vicente A.R.-D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M.N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J.J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P.P., Sieber C.C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S.D., Ebner N., Grutz R., von Haehling S., Schols A.M.W.J., Gosker H., Huysmans S., Quaaden S., Schols J.M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A.-M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G.A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P.-J., Teguo M.T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T.B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R.L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A.C., Yuan J., Roubenoff R., Kortebein P., Miller R.R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I.M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S.D., Feletti L., Marchioro E., Mocci F., Varesio M.G., Cesario A., Cabin B., de Boer W.P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A.-M., Mokhtari H., Rodon N., Epidemiology and Data Science, APH - Aging & Later Life, and APH - Quality of Care
Subjects: 0301 basic medicine, Gerontology, Sarcopenia, [SDV]Life Sciences [q-bio], Population, PROTEIN, RECOMMENDATIONS, law.invention, SUPPLEMENTATION, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Cultural diversity, medicine, Nutrition counselling, Nutrition intervention, Humans, 030212 general & internal medicine, Medical prescription, education, Exercise, Aged, 2. Zero hunger, education.field_of_study, 030109 nutrition & dietetics, Frailty, business.industry, Settore MED/09 - MEDICINA INTERNA, ADULTS, medicine.disease, mobility, 3. Good health, Feasibility Studie, Malnutrition, SPRINTT, resistance exercise, muscle mass, Protein intake, 3121 General medicine, internal medicine and other clinical medicine, Feasibility Studies, Energy intake, Independent Living, business, Nutrition counseling, Research Paper, Human
Abstract: Aim To describe the methods and feasibility of the nutritional intervention carried out within the SPRINTT Randomized cotrolled trial. We also illustrate how nutrition interventionists identified participants at risk of malnutrition and the lessons learnt from the nutrition intervention. Findings SPRINTT nutrition intervention was well-received by the majority of the participants. It was mainly carried out using tailored nutrition counselling, but also other means of delivering the intervention were successfully used. Compared with a standard nutrition prescription, an individualized protocol to diagnose malnutrition and follow-up by tailored nutrition counselling helped achieve nutritional targets more effectively in spite of diversity of population in nutritional habits and in some cases reluctance to accept changes. Message The SPRINTT nutrition intervention was feasible and allowed flexibility to the varying needs and cultural differences of this heterogeneous population of frail, older Europeans. It may serve as a model to educate and improve nutrition among community-dwelling older people at risk of mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4., Background The “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention. Methods SPRINTT RCT recruited older adults (≥ 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3–9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0–1.2 g/kg body weight, energy intake of 25–30 kcal/kg of body weight/day, and serum vitamin D concentration ≥ 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites. Results Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate. Conclusion The SPRINTT nutrition intervention was feasible and able to adapt flexibly to varying needs of this heterogeneous population. The procedures adopted to identify older adults at risk of malnutrition and to design the appropriate intervention may serve as a model to deliver nutrition intervention for community-dwelling older people with mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4.
Published: 2021
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33. Phylogeny of Symplocos Based on DNA Sequences of the Chloroplast trnC-trnD Intergenic Region

Author: Fritsch, Peter W., Cruz, Boni C., Almeda, Frank, Wang, Yuguo, and Shi, Suhua
Published: 2006

34. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author: Bajetta, E., Floriani, I., Di Bartolomeo, M., Labianca, R., Falcone, A., Di Costanzo, F., Comella, G., Amadori, D., Pinto, C., Carlomagno, C., Nitti, D., Daniele, B., Mini, E., Poli, D., Santoro, A., Mosconi, S., Casaretti, R., Boni, C., Pinotti, G., Bidoli, P., Landi, L., Rosati, G., Ravaioli, A., Cantore, M., Di Fabio, F., Aitini, E., Marchet, A., Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Poli, D., Mangano, S., Tonato, M., Zucca, E., Valsecchi, MG., Floriani, I., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Bajetta, E., Di Bartolomeo, M., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., DellʼOro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Labianca, R., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Amadori, D., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Falcone, A., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Di Costanzo, F., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Pinto, C., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Daniele, B., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Nitti, D., Marchet, A., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.
Published: 2014
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35. Clinical Evidence of Myocardial Damage in Patients with Acute Subarachnoid Hemorrhage

Author: Emdin, M., Di Pasquale, G., Boni, C., Urbinati, S., Buzzigoli, G., Lusa, A. M., Pinelli, G., L’Abbate, A., Di Pasquale, Giuseppe, editor, and Pinelli, Giuseppe, editor
Published: 1992
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36. Characterization of transcriptional and functional CD8 T cell heterogeneity to design individualized correction strategies for chronic HBV infection.

Author: Rossi, M., Vecchi, A., Guerrieri, F., Tiezzi, C., Plissonnier, M.L., Degasperi, E., Sambarino, D., Fisicaro, P., Gabor, E.A., Doselli, S., Farina, B., Missale, G., Lampertico, P., Ferrari, C., Levrero, M., and Boni, C.
Abstract: HBV-specific CD8 T cells are exhausted/dysfunctional in chronic HBV patients. Simultaneous staining with the exhaustion (PD-1) and memory (CD127) markers identifies two main subsets of HBV-specific CD8 T cells (PD1hiCD127low/- and PD1+CD127+) variably distributed in individual patients with HBeAg- chronic hepatitis. To characterize the transcriptional profiling and functional features of HBV-specific CD8 T cell subsets in patients with HBeAg- untreated chronic active hepatitis (CH) and in CH patients who achieved HBsAg clearance either spontaneously or by NUC therapy (Re) to better understand their role in HBV pathogenesis and to identify intracellular pathways relevant for HBV functional cure. Gene expression profiles of individual HBV core18-27-specific CD8 T cell subsets sorted by PD-1 and CD127 co-staining were analyzed by Nanostring, adapted for low-input samples (e.g. 1-10 cells) in 5 HBeAg- CH patients and in 6 Re patients. The analysis of checkpoint/differentiation molecules (CD39, Bcl-2), transcription factors (TOX, TCF1) and cytokines (TNF-a and IFN-g) by flow cytometry was performed in an expanded cohort of 21 CH and 11 Re patients. Transcriptional analysis of HBV-specific CD8 T cell subsets shows an enrichment in exhaustion-related genes in the PD1hiCD127low/- subset as compared to PD1+CD127+ memory like (ML) cells in CH patients, which is even more significant when the comparison focuses on PD1+CD127+ ML cells of Re patients. A signature of 13 genes identifies the progressive transition from the more exhaustion-oriented PD1hiCD127low/- CD8 T cells of CH patients to the intermediate phenotype of PD1+CD127+ T cells of CH patients and the more memory-oriented PD1+CD127+ ML T cells of Re HBsAg- patients. Our study identifies distinct exhaustion signatures in the different HBV-specific CD8 T cell subsets that coexist at different ratios in the distinct phases of the disease and that may guide individualized transcriptional/functional correction therapies for CHB patients. [ABSTRACT FROM AUTHOR]
Published: 2025
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37. Strategies to enhance Natural Killer cell response in Hepatocellular Carcinoma: The role of TGFβ in NK-Cells (dys)function and plasticity.

Author: Reverberi, V., Montali, A., Pelagatti, A., Vecchi, A., Rossi, M., Doselli, S., Farina, B., Olivani, A., Economopoulos, G., Valle, R. Dalla, Fisicaro, P., Boni, C., and Missale, G.
Abstract: The tumor immune microenvironment (TIME), characterized by elevated transforming growth factor-β (TGF-β) levels, alongside hypoxia and nutrient deprivation, often leads to tumor-infiltrating NK (TINK) cells dysfunction. TGF-β is a key regulator within TIME, influencing NK cell plasticity and functionality. Despite its well-established immunosuppressive effects, the molecular mechanisms underlying TGF-β's impact on NK cells remain incompletely understood, and its role may not be entirely deleterious, reflecting a complex and context-dependent function. This study investigates the impact of TGF-β on TINK subsets, focusing on ILC1-like, CD56Bright CD49a+ and conventional NK (cNK) cells. Given TGF-β's role in driving the phenotypic plasticity of these cells, the activation of both SMAD- and TAK1-dependent TGF-β pathways was evaluated. By analyzing mitochondrial membrane depolarization, DNA damage response, and cytokine production, we seek to elucidate TGF-β's impact on NK-cell functionality. CD56bright/CD49a+ and ILC1-like (CD103+CD49a+CD9+) NK-cells were enriched in the tumor microenvironment, particularly in viral-related hepatocellular carcinoma (HCC), and nearly absent in the liver. TAK1-dependent TGF-β pathway activation was significantly higher in the tumor compared to the liver, and overall, greater than SMAD-dependent activation with highest levels in ILC1-like cells. CD56Bright CD49a+, ILC1-like and cNK (negative for CD103, CD49a and CD9) exhibited higher H2AX phosphorylation in the tumor compartment and an interesting positive correlation was found between mitochondrial depolarization and both H2AX and TAK1 phosphorylation. Finally, ILC1-like TINKs showed higher TNF-α production than their liver counterpart and tumor infiltrating cNK and opposite behavior for IFN-γ production. TGF-β impacts NK cell functionality and phenotypic plasticity within the TIME and, particularly through the TAK1 pathway, leads to mitochondrial dysfunction, DNA damage and a shift in cytokine profiles that might aid immune evasion. These findings highlight TGF-β's complex role and suggest targeting its pathway to enhance NK cell function in cancer. [ABSTRACT FROM AUTHOR]
Published: 2025
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38. Reticulate evolution, cryptic species, and character convergence in the core East Asian clade of Gaultheria (Ericaceae)

Author: Lu, Lu, Fritsch, Peter W., Cruz, Boni C., Wang, Hong, and Li, De-Zhu
Published: 2010
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39. Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

Author: Huckins, L M, Hatzikotoulas, K, Southam, L, Thornton, L M, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, A, Palotie, A, Palta, P, van Rooij, F J A, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, G-P, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, A H, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, Collier, D A, Sullivan, P F, Breen, G, Bulik, C M, and Zeggini, E
Published: 2018
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40. Phylogeny of Caragana (Fabaceae) based on DNA sequence data from rbcL, trnS– trnG, and ITS

Author: Zhang, Mingli, Fritsch, Peter W., and Cruz, Boni C.
Published: 2009
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41. The Breast Avastin Trial: phase II study of bevacizumab maintenance therapy after induction chemotherapy with docetaxel and capecitabine for the first-line treatment of patients with locally recurrent or metastatic breast cancer

Author: Bisagni, G., Musolino, A., Panebianco, M., De Matteis, A., Nuzzo, F., Ardizzoni, A., Gori, S., Gamucci, T., Passalacqua, R., Gnoni, R., Moretti, G., and Boni, C.
Published: 2013
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42. A LIKELY INTERSECTIONAL HYBRID IN VACCINIUM (ERICACEAE) ON SAN BRUNO MOUNTAIN, SAN MATEO COUNTY, CALIFORNIA

Author: W. Brian Simison, Douglas D. Allshouse, Boni C. Cruz, Edward L. Schneider, and Peter W. Fritsch
Subjects: 0106 biological sciences, 0301 basic medicine, education.field_of_study, biology, Population, Vaccinium cespitosum, Evergreen, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, 030104 developmental biology, Ericaceae, Botany, Internal transcribed spacer, education, NdhF, Hybrid, Vaccinium
Abstract: A population of Vaccinium from San Bruno Mountain in San Mateo County, California has been confused with V. cespitosum Michx. (V. sect. Myrtillus), a species documented from the mountain, since its initial collection in 1961. These plants resemble V. cespitosum and other species in V. sect. Myrtillus in several characters, but differ most notably in their evergreen habit and well developed calyx lobes. The latter characters are shared by V. ovatum Pursh (V. sect. Pyxothamnus), the only other species of Vaccinium known from San Bruno Mountain, suggesting that the population is a hybrid between V. cespitosum and V. ovatum. We used data from gross morphology, leaf anatomy, and DNA sequences from the nuclear ribosomal internal transcribed spacer (ITS) and plastid matK and ndhF regions to test the hybrid status of this population. Hybrid status is supported by: 1) a plastid sequence profile identical to that of V. cespitosum from San Bruno Mountain and different from the profiles of all other Vaccinium samples in the study, 2) an ITS profile that differs from V. cespitosum from the mountain by only two polymorphic sites, and 3) the possession of gross morphological and anatomical characters that are either shared with one putative parent or the other, or are intermediate between them. Although ITS variation was non-additive and closely matched one of the putative parents, uniparental inheritance has been observed in other hybrids. Two novel gross morphological characters were also observed in the hybrid. The study documents a case of likely intersectional hybridization within Vaccinium, only rarely observed under natural conditions. Vaccinium cespitosum may have been outcompeted by the hybrid to the point of its extirpation from San Bruno Mountain. The population is here newly described as the nothospecies Vaccinium ×brunoense P.W.Fritsch, occurring in an area of only ca. 200 m2 with the number of individuals remaining uncertain because of clonal growth.
Published: 2021
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43. Is There a Role for Hormonal Therapy in Neuroendocrine Carcinoma of the Breast? A Paradigmatic Case Report

Author: Pagano, M., Asensio, S. N.M., Zanelli, F., Lococo, F., Cavazza, A., Damiani, S., Rapicetta, C., Gnoni, R., and Boni, C.
Published: 2014
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44. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

Author: Fisicaro, P., Valdatta, C., Boni, C., Massari, M., Mori, C., Zerbini, A., Orlandini, A., Sacchelli, L., Missale, G., and Ferrari, C.
Subjects: Hepatitis B -- Development and progression, Hepatitis B -- Research, Immune response -- Research, Health
Published: 2009

45. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Author: Munn-Chernoff, M.A. Johnson, E.C. Chou, Y.-L. Coleman, J.R.I. Thornton, L.M. Walters, R.K. Yilmaz, Z. Baker, J.H. Hübel, C. Gordon, S. Medland, S.E. Watson, H.J. Gaspar, H.A. Bryois, J. Hinney, A. Leppä, V.M. Mattheisen, M. Ripke, S. Yao, S. Giusti-Rodríguez, P. Hanscombe, K.B. Adan, R.A.H. Alfredsson, L. Ando, T. Andreassen, O.A. Berrettini, W.H. Boehm, I. Boni, C. Boraska Perica, V. Buehren, K. Burghardt, R. Cassina, M. Cichon, S. Clementi, M. Cone, R.D. Courtet, P. Crow, S. Crowley, J.J. Danner, U.N. Davis, O.S.P. de Zwaan, M. Dedoussis, G. Degortes, D. DeSocio, J.E. Dick, D.M. Dikeos, D. Dina, C. Dmitrzak-Weglarz, M. Docampo, E. Duncan, L.E. Egberts, K. Ehrlich, S. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Favaro, A. Fernández-Aranda, F. Fichter, M.M. Fischer, K. Föcker, M. Foretova, L. Forstner, A.J. Forzan, M. Franklin, C.S. Gallinger, S. Giegling, I. Giuranna, J. Gonidakis, F. Gorwood, P. Gratacos Mayora, M. Guillaume, S. Guo, Y. Hakonarson, H. Hatzikotoulas, K. Hauser, J. Hebebrand, J. Helder, S.G. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Huckins, L.M. Hudson, J.I. Imgart, H. Inoko, H. Janout, V. Jiménez-Murcia, S. Julià, A. Kalsi, G. Kaminská, D. Karhunen, L. Karwautz, A. Kas, M.J.H. Kennedy, J.L. Keski-Rahkonen, A. Kiezebrink, K. Kim, Y.-R. Klump, K.L. Knudsen, G.P.S. La Via, M.C. Le Hellard, S. Levitan, R.D. Li, D. Lilenfeld, L. Lin, B.D. Lissowska, J. Luykx, J. Magistretti, P.J. Maj, M. Mannik, K. Marsal, S. Marshall, C.R. Mattingsdal, M. McDevitt, S. McGuffin, P. Metspalu, A. Meulenbelt, I. Micali, N. Mitchell, K. Monteleone, A.M. Monteleone, P. Nacmias, B. Navratilova, M. Ntalla, I. O'Toole, J.K. Ophoff, R.A. Padyukov, L. Palotie, A. Pantel, J. Papezova, H. Pinto, D. Rabionet, R. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Santonastaso, P. Scherag, A. Scherer, S.W. Schmidt, U. Schork, N.J. Schosser, A. Seitz, J. Slachtova, L. Slagboom, P.E. Slof-Op't Landt, M.C.T. Slopien, A. Sorbi, S. Świątkowska, B. Szatkiewicz, J.P. Tachmazidou, I. Tenconi, E. Tortorella, A. Tozzi, F. Treasure, J. Tsitsika, A. Tyszkiewicz-Nwafor, M. Tziouvas, K. van Elburg, A.A. van Furth, E.F. Wagner, G. Walton, E. Widen, E. Zeggini, E. Zerwas, S. Zipfel, S. Bergen, A.W. Boden, J.M. Brandt, H. Crawford, S. Halmi, K.A. Horwood, L.J. Johnson, C. Kaplan, A.S. Kaye, W.H. Mitchell, J. Olsen, C.M. Pearson, J.F. Pedersen, N.L. Strober, M. Werge, T. Whiteman, D.C. Woodside, D.B. Grove, J. Henders, A.K. Larsen, J.T. Parker, R. Petersen, L.V. Jordan, J. Kennedy, M.A. Birgegård, A. Lichtenstein, P. Norring, C. Landén, M. Mortensen, P.B. Polimanti, R. McClintick, J.N. Adkins, A.E. Aliev, F. Bacanu, S.-A. Batzler, A. Bertelsen, S. Biernacka, J.M. Bigdeli, T.B. Chen, L.-S. Clarke, T.-K. Degenhardt, F. Docherty, A.R. Edwards, A.C. Foo, J.C. Fox, L. Frank, J. Hack, L.M. Hartmann, A.M. Hartz, S.M. Heilmann-Heimbach, S. Hodgkinson, C. Hoffmann, P. Hottenga, J.-J. Konte, B. Lahti, J. Lahti-Pulkkinen, M. Lai, D. Ligthart, L. Loukola, A. Maher, B.S. Mbarek, H. McIntosh, A.M. McQueen, M.B. Meyers, J.L. Milaneschi, Y. Palviainen, T. Peterson, R.E. Ryu, E. Saccone, N.L. Salvatore, J.E. Sanchez-Roige, S. Schwandt, M. Sherva, R. Streit, F. Strohmaier, J. Thomas, N. Wang, J.-C. Webb, B.T. Wedow, R. Wetherill, L. Wills, A.G. Zhou, H. Boardman, J.D. Chen, D. Choi, D.-S. Copeland, W.E. Culverhouse, R.C. Dahmen, N. Degenhardt, L. Domingue, B.W. Frye, M.A. Gäebel, W. Hayward, C. Ising, M. Keyes, M. Kiefer, F. Koller, G. Kramer, J. Kuperman, S. Lucae, S. Lynskey, M.T. Maier, W. Mann, K. Männistö, S. Müller-Myhsok, B. Murray, A.D. Nurnberger, J.I. Preuss, U. Räikkönen, K. Reynolds, M.D. Ridinger, M. Scherbaum, N. Schuckit, M.A. Soyka, M. Treutlein, J. Witt, S.H. Wodarz, N. Zill, P. Adkins, D.E. Boomsma, D.I. Bierut, L.J. Brown, S.A. Bucholz, K.K. Costello, E.J. de Wit, H. Diazgranados, N. Eriksson, J.G. Farrer, L.A. Foroud, T.M. Gillespie, N.A. Goate, A.M. Goldman, D. Grucza, R.A. Hancock, D.B. Harris, K.M. Hesselbrock, V. Hewitt, J.K. Hopfer, C.J. Iacono, W.G. Johnson, E.O. Karpyak, V.M. Kendler, K.S. Kranzler, H.R. Krauter, K. Lind, P.A. McGue, M. MacKillop, J. Madden, P.A.F. Maes, H.H. Magnusson, P.K.E. Nelson, E.C. Nöthen, M.M. Palmer, A.A. Penninx, B.W.J.H. Porjesz, B. Rice, J.P. Rietschel, M. Riley, B.P. Rose, R.J. Shen, P.-H. Silberg, J. Stallings, M.C. Tarter, R.E. Vanyukov, M.M. Vrieze, S. Wall, T.L. Whitfield, J.B. Zhao, H. Neale, B.M. Wade, T.D. Heath, A.C. Montgomery, G.W. Martin, N.G. Sullivan, P.F. Kaprio, J. Breen, G. Gelernter, J. Edenberg, H.J. Bulik, C.M. Agrawal, A.
Subjects: mental disorders
Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. © 2020 Society for the Study of Addiction
Published: 2021

46. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Author: Munn-Chernoff, M.A. Johnson, E.C. Chou, Y.-L. Coleman, J.R.I. Thornton, L.M. Walters, R.K. Yilmaz, Z. Baker, J.H. Hübel, C. Gordon, S. Medland, S.E. Watson, H.J. Gaspar, H.A. Bryois, J. Hinney, A. Leppä, V.M. Mattheisen, M. Ripke, S. Yao, S. Giusti-Rodríguez, P. Hanscombe, K.B. Adan, R.A.H. Alfredsson, L. Ando, T. Andreassen, O.A. Berrettini, W.H. Boehm, I. Boni, C. Boraska Perica, V. Buehren, K. Burghardt, R. Cassina, M. Cichon, S. Clementi, M. Cone, R.D. Courtet, P. Crow, S. Crowley, J.J. Danner, U.N. Davis, O.S.P. de Zwaan, M. Dedoussis, G. Degortes, D. DeSocio, J.E. Dick, D.M. Dikeos, D. Dina, C. Dmitrzak-Weglarz, M. Docampo, E. Duncan, L.E. Egberts, K. Ehrlich, S. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Favaro, A. Fernández-Aranda, F. Fichter, M.M. Fischer, K. Föcker, M. Foretova, L. Forstner, A.J. Forzan, M. Franklin, C.S. Gallinger, S. Giegling, I. Giuranna, J. Gonidakis, F. Gorwood, P. Gratacos Mayora, M. Guillaume, S. Guo, Y. Hakonarson, H. Hatzikotoulas, K. Hauser, J. Hebebrand, J. Helder, S.G. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Huckins, L.M. Hudson, J.I. Imgart, H. Inoko, H. Janout, V. Jiménez-Murcia, S. Julià, A. Kalsi, G. Kaminská, D. Karhunen, L. Karwautz, A. Kas, M.J.H. Kennedy, J.L. Keski-Rahkonen, A. Kiezebrink, K. Kim, Y.-R. Klump, K.L. Knudsen, G.P.S. La Via, M.C. Le Hellard, S. Levitan, R.D. Li, D. Lilenfeld, L. Lin, B.D. Lissowska, J. Luykx, J. Magistretti, P.J. Maj, M. Mannik, K. Marsal, S. Marshall, C.R. Mattingsdal, M. McDevitt, S. McGuffin, P. Metspalu, A. Meulenbelt, I. Micali, N. Mitchell, K. Monteleone, A.M. Monteleone, P. Nacmias, B. Navratilova, M. Ntalla, I. O'Toole, J.K. Ophoff, R.A. Padyukov, L. Palotie, A. Pantel, J. Papezova, H. Pinto, D. Rabionet, R. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Santonastaso, P. Scherag, A. Scherer, S.W. Schmidt, U. Schork, N.J. Schosser, A. Seitz, J. Slachtova, L. Slagboom, P.E. Slof-Op&apos and Munn-Chernoff, M.A. Johnson, E.C. Chou, Y.-L. Coleman, J.R.I. Thornton, L.M. Walters, R.K. Yilmaz, Z. Baker, J.H. Hübel, C. Gordon, S. Medland, S.E. Watson, H.J. Gaspar, H.A. Bryois, J. Hinney, A. Leppä, V.M. Mattheisen, M. Ripke, S. Yao, S. Giusti-Rodríguez, P. Hanscombe, K.B. Adan, R.A.H. Alfredsson, L. Ando, T. Andreassen, O.A. Berrettini, W.H. Boehm, I. Boni, C. Boraska Perica, V. Buehren, K. Burghardt, R. Cassina, M. Cichon, S. Clementi, M. Cone, R.D. Courtet, P. Crow, S. Crowley, J.J. Danner, U.N. Davis, O.S.P. de Zwaan, M. Dedoussis, G. Degortes, D. DeSocio, J.E. Dick, D.M. Dikeos, D. Dina, C. Dmitrzak-Weglarz, M. Docampo, E. Duncan, L.E. Egberts, K. Ehrlich, S. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Favaro, A. Fernández-Aranda, F. Fichter, M.M. Fischer, K. Föcker, M. Foretova, L. Forstner, A.J. Forzan, M. Franklin, C.S. Gallinger, S. Giegling, I. Giuranna, J. Gonidakis, F. Gorwood, P. Gratacos Mayora, M. Guillaume, S. Guo, Y. Hakonarson, H. Hatzikotoulas, K. Hauser, J. Hebebrand, J. Helder, S.G. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Huckins, L.M. Hudson, J.I. Imgart, H. Inoko, H. Janout, V. Jiménez-Murcia, S. Julià, A. Kalsi, G. Kaminská, D. Karhunen, L. Karwautz, A. Kas, M.J.H. Kennedy, J.L. Keski-Rahkonen, A. Kiezebrink, K. Kim, Y.-R. Klump, K.L. Knudsen, G.P.S. La Via, M.C. Le Hellard, S. Levitan, R.D. Li, D. Lilenfeld, L. Lin, B.D. Lissowska, J. Luykx, J. Magistretti, P.J. Maj, M. Mannik, K. Marsal, S. Marshall, C.R. Mattingsdal, M. McDevitt, S. McGuffin, P. Metspalu, A. Meulenbelt, I. Micali, N. Mitchell, K. Monteleone, A.M. Monteleone, P. Nacmias, B. Navratilova, M. Ntalla, I. O'Toole, J.K. Ophoff, R.A. Padyukov, L. Palotie, A. Pantel, J. Papezova, H. Pinto, D. Rabionet, R. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Santonastaso, P. Scherag, A. Scherer, S.W. Schmidt, U. Schork, N.J. Schosser, A. Seitz, J. Slachtova, L. Slagboom, P.E. Slof-Op&apos
Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substanc
Published: 2021

47. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Author: Munn-Chernoff, MA, Johnson, EC, Chou, YL, Coleman, JRI, Thornton, LM, Walters, RK, Yilmaz, Z, Baker, JH, Hübel, C, Gordon, S, Medland, SE, Watson, HJ, Gaspar, HA, Bryois, J, Hinney, A, Leppä, VM, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, KB, Adan, RAH, Alfredsson, L, Ando, T, Andreassen, OA, Berrettini, WH, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, RD, Courtet, P, Crow, S, Crowley, JJ, Danner, UN, Davis, OS, Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, JE, Dick, DM, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, LE, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, MM, Fischer, K, Föcker, M, Foretova, L, Forstner, AJ, Forzan, M, Franklin, CS, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, SG, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, LM, Hudson, JI, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, MJH, Kennedy, JL, Keski-Rahkonen, A, Kiezebrink, K, Kim, YR, Klump, KL, Knudsen, GP, La Via, MC, Le Hellard, S, Levitan, RD, Li, D, Lilenfeld, L, Lin, BD, Lissowska, J, Luykx, J, Magistretti, PJ, Maj, M, Mannik, K, Marsal, S, Marshall, CR, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, JK, Ophoff, Roel, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, SW, Schmidt, U, Schork, NJ, Schosser, A, Seitz, J, Slachtova, L, Slagboom, PE, Slof-Op't Landt, MCT, Slopien, A, Sorbi, S, ?wi?tkowska, B, Szatkiewicz, JP, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, AA, van Furth, EF, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, AW, Boden, JM, Brandt, H, Crawford, S, Halmi, KA, Horwood, LJ, Johnson, C, Kaplan, AS, Kaye, WH, Mitchell, J E, Olsen, CM, Pearson, JF, Pedersen, NL, Strober, M, Werge, T, Whiteman, DC, Woodside, DB, Grove, J, Henders, AK, Larsen, J T, Parker, R, Petersen, LV, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, PB, Polimanti, R, McClintick, JN, Adkins, AE, Aliev, F, Bacanu, SA, Batzler, A, Bertelsen, S, Biernacka, JM, Bigdeli, TB, Chen, L S, Clarke, TK, Degenhardt, F, Docherty, AR, Edwards, AC, Foo, JC, Fox, L, Frank, J, Hack, LM, Hartmann, AM, Hartz, SM, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, JJ, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, BS, Mbarek, H, McIntosh, AM, McQueen, MB, Meyers, JL, Milaneschi, Y, Palviainen, T, Peterson, RE, Ryu, E, Saccone, N L, Salvatore, JE, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, JCY, Webb, BT, Wedow, R, Wetherill, L, Wills, AG, Zhou, H, Boardman, JD, Chen, D, Choi, D S, Copeland, WE, Culverhouse, RC, Dahmen, N, Degenhardt, L, Domingue, BW, Frye, MA, Gäebel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J (John), Kuperman, S, Lucae, S, Lynskey, MT, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, AD, Nurnberger, JI, Preuss, U, Räikkönen, K, Reynolds, MD, Ridinger, M, Scherbaum, N, Schuckit, MA, Soyka, M, Treutlein, J, Witt, SH, Wodarz, N, Zill, P, Adkins, DE, Boomsma, DI, Bierut, LJ, Brown, S, Bucholz, KK, Costello, EJ, Wit, HJ, Diazgranados, N, Eriksson, JG, Farrer, LA, Foroud, TM, Gillespie, NA, Goate, AM, Goldman, D, Grucza, RA, Hancock, DB, Harris, KM, Hesselbrock, V, Hewitt, JK, Hopfer, CJ, Iacono, WG, Johnson, E O, Karpyak, VM, Kendler, KS, Kranzler, HR, Krauter, K, Lind, PA, McGue, M, MacKillop, J, Madden, PA, Maes, HH, Magnusson, PKE, Nelson, EC, Nöthen, MM, Palmer, AA, Penninx, BWJH, Porjesz, B, Rice, JP, Rietschel, M, Riley, BP, Rose, RJ, Shen, PH, Silberg, J, Stallings, MC, Tarter, RE, Vanyukov, MM, Vrieze, S, Wall, TL, Whitfield, JB, Zhao, H, Neale, BM, Wade, TD, Heath, AC, Montgomery, GW, Martin, NG, Sullivan, PF, Kaprio, J, Breen, G, Gelernter, J, Edenberg, HJ, Bulik, CM, Agrawal, A, Munn-Chernoff, MA, Johnson, EC, Chou, YL, Coleman, JRI, Thornton, LM, Walters, RK, Yilmaz, Z, Baker, JH, Hübel, C, Gordon, S, Medland, SE, Watson, HJ, Gaspar, HA, Bryois, J, Hinney, A, Leppä, VM, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, KB, Adan, RAH, Alfredsson, L, Ando, T, Andreassen, OA, Berrettini, WH, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, RD, Courtet, P, Crow, S, Crowley, JJ, Danner, UN, Davis, OS, Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, JE, Dick, DM, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, LE, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, MM, Fischer, K, Föcker, M, Foretova, L, Forstner, AJ, Forzan, M, Franklin, CS, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, SG, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, LM, Hudson, JI, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, MJH, Kennedy, JL, Keski-Rahkonen, A, Kiezebrink, K, Kim, YR, Klump, KL, Knudsen, GP, La Via, MC, Le Hellard, S, Levitan, RD, Li, D, Lilenfeld, L, Lin, BD, Lissowska, J, Luykx, J, Magistretti, PJ, Maj, M, Mannik, K, Marsal, S, Marshall, CR, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, JK, Ophoff, Roel, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, SW, Schmidt, U, Schork, NJ, Schosser, A, Seitz, J, Slachtova, L, Slagboom, PE, Slof-Op't Landt, MCT, Slopien, A, Sorbi, S, ?wi?tkowska, B, Szatkiewicz, JP, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, AA, van Furth, EF, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, AW, Boden, JM, Brandt, H, Crawford, S, Halmi, KA, Horwood, LJ, Johnson, C, Kaplan, AS, Kaye, WH, Mitchell, J E, Olsen, CM, Pearson, JF, Pedersen, NL, Strober, M, Werge, T, Whiteman, DC, Woodside, DB, Grove, J, Henders, AK, Larsen, J T, Parker, R, Petersen, LV, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, PB, Polimanti, R, McClintick, JN, Adkins, AE, Aliev, F, Bacanu, SA, Batzler, A, Bertelsen, S, Biernacka, JM, Bigdeli, TB, Chen, L S, Clarke, TK, Degenhardt, F, Docherty, AR, Edwards, AC, Foo, JC, Fox, L, Frank, J, Hack, LM, Hartmann, AM, Hartz, SM, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, JJ, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, BS, Mbarek, H, McIntosh, AM, McQueen, MB, Meyers, JL, Milaneschi, Y, Palviainen, T, Peterson, RE, Ryu, E, Saccone, N L, Salvatore, JE, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, JCY, Webb, BT, Wedow, R, Wetherill, L, Wills, AG, Zhou, H, Boardman, JD, Chen, D, Choi, D S, Copeland, WE, Culverhouse, RC, Dahmen, N, Degenhardt, L, Domingue, BW, Frye, MA, Gäebel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J (John), Kuperman, S, Lucae, S, Lynskey, MT, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, AD, Nurnberger, JI, Preuss, U, Räikkönen, K, Reynolds, MD, Ridinger, M, Scherbaum, N, Schuckit, MA, Soyka, M, Treutlein, J, Witt, SH, Wodarz, N, Zill, P, Adkins, DE, Boomsma, DI, Bierut, LJ, Brown, S, Bucholz, KK, Costello, EJ, Wit, HJ, Diazgranados, N, Eriksson, JG, Farrer, LA, Foroud, TM, Gillespie, NA, Goate, AM, Goldman, D, Grucza, RA, Hancock, DB, Harris, KM, Hesselbrock, V, Hewitt, JK, Hopfer, CJ, Iacono, WG, Johnson, E O, Karpyak, VM, Kendler, KS, Kranzler, HR, Krauter, K, Lind, PA, McGue, M, MacKillop, J, Madden, PA, Maes, HH, Magnusson, PKE, Nelson, EC, Nöthen, MM, Palmer, AA, Penninx, BWJH, Porjesz, B, Rice, JP, Rietschel, M, Riley, BP, Rose, RJ, Shen, PH, Silberg, J, Stallings, MC, Tarter, RE, Vanyukov, MM, Vrieze, S, Wall, TL, Whitfield, JB, Zhao, H, Neale, BM, Wade, TD, Heath, AC, Montgomery, GW, Martin, NG, Sullivan, PF, Kaprio, J, Breen, G, Gelernter, J, Edenberg, HJ, Bulik, CM, and Agrawal, A
Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotyp
Published: 2021

48. Leaf adaptations and species boundaries in North American Cercis : implications for the evolution of dry floras

Author: Dylan O. Burge, Camille F. Nowell, Peter W. Fritsch, Boni C. Cruz, Alfonso Delgado-Salinas, Lila Leatherman, and Wei Gong
Subjects: 0106 biological sciences, 0301 basic medicine, Species complex, DNA, Plant, Biogeography, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, Genetics, Leaf size, Clade, Ecosystem, Phylogeny, Ecology, Evolution, Behavior and Systematics, Demography, Morphometrics, Phylogenetic tree, Ecology, Cercis, Fabaceae, 15. Life on land, biology.organism_classification, Biological Evolution, Plant Leaves, 030104 developmental biology, Herbarium, North America
Abstract: PREMISE OF THE STUDY The North American Cercis clade spans dry to mesic climates and exhibits complex morphological variation. We tested various proposed species classifications of this group and whether aspects of leaf morphology, particularly the "drip-tip" in some regional populations, are adaptive and/or linked with phylogeny. METHODS We made measurements on over 1100 herbarium specimens from throughout North America and analyzed the data with univariate and multivariate approaches. We analyzed phylogenetically DNA sequence data from nuclear ITS and three plastid regions from 40 samples, and estimated divergence times with a relaxed-clock Bayesian analysis. We used climate and geographic position data to predict the variation observed in leaf size and shape by using stepwise multiple linear regressions. KEY RESULTS Morphometric analyses yielded a pattern of continuous and often clinal character variation across North America, without correlated gaps in character states. Conversely, phylogenetic and divergence time analyses yielded distinct clades from California, the interior west, and eastern North America separated by between ~12 and 16 million years. Multiple regressions yielded highly significant correlations between leaf apex shape and precipitation of the warmest quarter. CONCLUSIONS Despite a pattern of continuous morphological character variation, the long period of geographic and presumably genetic isolation warrants the delimitation of three species. Predictive modeling supports the adaptive value of acuminate apices or "drip-tips" in mesic habitats. This suggests that Cercis leaves change more rapidly than inferred from parsimony reconstruction, which has implications for the evolution of the dry floras of North America and Eurasia.
Published: 2018
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49. A LIKELY INTERSECTIONAL HYBRID IN VACCINIUM (ERICACEAE) ON SAN BRUNO MOUNTAIN, SAN MATEO COUNTY, CALIFORNIA

Author: Fritsch, Peter W., primary, Simison, W. Brian, additional, Cruz, Boni C., additional, Schneider, Edward L., additional, and Allshouse, Douglas D., additional
Published: 2021
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50. Phylogeny and infrageneric classification of Symplocos (Symplocaceae) inferred from DNA sequence data

Author: Wang, Yuguo, Fritsch, Peter W., Shi, Suhua, Almeda, Frank, Cruz, Boni C., and Kelly, Lawrence M.
Subjects: Phylogeny, DNA, Genetic research, Biological sciences
Abstract: Symplocos comprises ~300 species of woody flowering plants with a disjunct distribution between the warm-temperate to tropical regions of eastern Asia and the Americas. Phylogenetic analyses of 111 species of Symplocos based on the nuclear ribosomal internal transcribed spacer (ITS) region and the chloroplast genes rp1l6, matK, and trnL-trnF yielded topologies in which only one of the four traditionally recognized subgenera (Epigenia; Neotropics) is monophyletic. Section Corclyloblaste (subgenus Symplocos; eastern Asia) is monophyletic and sister to a group comprising all other samples of Symplocos. Section Palura (subgenus Hopea; eastern Asia) is sister to a group comprising all other samples of Symplocos except those of section Cordyloblaste. Symplocos wikstroemiifolia (eastern Asia) and S. tinctoria (southeastern United States), both of subgenus Hopea, form a clade that groups with S. longipes (tropical North America) and the species of subgenus Epigenia. The remaining samples of subgenus Hopea (eastern Asia) form a clade. Section Neosymplocos (subgenus Microsymplocos; Neotropics) is well nested within a clade otherwise comprising the samples of section Symplocastrum (subgenus Symplocos; Neotropics). Section Urbaniocharis (subgenus Microsymplocos; Antilles) groups as sister to the clade comprising Symplocastrum and Neosymplocos. The data support the independent evolution of deciduousness among section Palura and S. tinctoria. The early initial divergence of sections Cordyloblaste and Palura from the main group warrants their recognition at taxonomic levels higher than those at which they are currently placed. An inferred eastern Asian origin for Symplocos with subsequent dispersal to the Americas is consistent with patterns from other phylogenetic studies of eastern Asian-American disjunct plant groups but contrary to a North American origin inferred from the earliest fossil occurrences of the genus. Key words: disjunction: ITS; matK; phylogeny; rp116; Symplocaceae; Symplocos; trnL-trnF.
Published: 2004

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