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2. Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells

Author

Frasca G, Cardile V, Puglia C, Bonina C, and Bonina F

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Giuseppina Frasca1, Venera Cardile1, Carmelo Puglia2, Claudia Bonina2, Francesco Bonina21Department of Biomedical Sciences, (Physiology), 2Department of Drug Sciences, University of Catania, Catania, ItalyBackground: Gelatin tannate is a mixture of tannic acid and gelatin. Tannic acid has astringent properties, due to its capacity to form protein–macromolecular complexes, as well as antibacterial and antioxidant properties. However, little is known about its anti-inflammatory properties. Purpose: To evaluate the anti-inflammatory activity of gelatin tannate by quantifying the suppression of key molecules produced during inflammatory events in lipopolysaccharide (LPS)-stimulated human intestinal cells. Methods: Intercellular adhesion molecule-1 (ICAM-1) expression was determined by Western blot analysis; interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) concentrations were measured by enzyme-linked immunosorbent assays in Caco-2 cells 24 hours after treatment with LPS (1 μg/mL) in presence of different concentrations of gelatin tannate. Results: ICAM-1 is induced on a wide variety of cells by inflammatory stimuli such as LPS. Our results have shown gelatin tannate as a potent inhibitor of ICAM-1 expression in LPS-stimulated Caco-2 cells. IL-8 and TNF-α are important inflammatory mediators, recruiting neutrophils and T-lymphocytes. Together with LPS, adding gelatin tannate at different concentrations induced a dose-dependent inhibition of IL-8 and TNF-α released by Caco-2 cells. Conclusion: These results suggest that gelatin tannate exerts anti-inflammatory effects by inhibiting the specific cytokines and adhesion molecules involved in several inflammatory disorders.Keywords: Caco-2, ICAM-1, IL-8, TNF-α

Published
2012

4. The in vitro effect of a lyophilized extract of wine obtained from Jacquez grapes on human chondrocytes

Author

Panico, A.M., Cardile, V., Avondo, S., Garufi, F., Gentile, B., Puglia, C., Bonina, F., Santagati, N.A., and Ronsisvalle, G.

Subjects
Drug therapy, Usage, Analysis, Osteoarthritis -- Drug therapy, Cytological research -- Analysis -- Usage, Antioxidants (Nutrients) -- Usage, Cell research -- Analysis -- Usage, Antioxidants -- Usage
Abstract

The present work was aimed at evaluating the in vitro effects of a lyophilized extract of wine (JW-E) obtained from Jacquez grapes (Vitis aestivalis-cinerea x Vitis vinifera grapes) on the [...]

Published
2006

10. Antiulcer Potential of a Standardized Extract of Red Orange Juice in the Rat

Author

Federica, Vitali, Antonella, Saija, Bonina, F., Franchitto, S., Artico, Marco, and Tita, Beatrice

Subjects
Orange juice, business.industry, red orange complex (roc), Gastric lesions, Orange (colour), Pharmacology, antiulcer activity, rat, scanning electronic microscopy, Biochemistry, In vivo, Oral administration, Medicine, Electronic microscopy, business, Food Science, Animal use
Abstract

A standardized red orange extract (Red Orange Complex, ROC) has been evaluated for its potential protective effect on ethanol- and indomethacin-induced gastric lesions in rats. Oral administration of the ROC significantly prevented the development of gastric lesions in these experimental models. In addition, the effect of the ROC on the spontaneous healing of acetylsalicylic acid (ASA) ulcers in rats was examined. The spontaneous healing of gastric ulcer was significantly accelerated by repeated administration of the ROC. The histological condition of the mucosa, examined by scanning electronic microscopy (SEM), confirmed the in vivo data. The results, on the whole, indicate that the ROC possesses favourable antiulcer and cytoprotective properties in rat. This study was performed according to the international principles for laboratory animal use and care (EEC Directive of 1986; 86/609/EEC).

Published
2007
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11. Red orange extract: effect on DNA cleavage

Author

Russo, A., Bonina, F., Acquaviva, R., Campisi, A., Galvano, F., Ragusa, N., and Vanella, A.

Subjects
Lipids -- Usage, DNA -- Analysis, Free radicals (Chemistry) -- Analysis, Business, Food/cooking/nutrition
Abstract

Effects of lipid oxidation of red orange extract on DNA cleavage of extract and its free radical content are described.

Published
2002

29. Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds

Author

Arena, Adriana, Bisignano, G., Pavone, B., Tomaino, Antonio, Bonina, F. P., Saija, Antonina, Cristani, Mariateresa, D'Arrigo, Manuela, and Trombetta, Domenico

Subjects
Herpesvirus 2, Human, Methanol, IMMUNE, HERPES-SIMPLEX-VIRUS, FLAVONOIDS, IN-VITRO, Flowers, BLOOD MONONUCLEAR-CELLS, Virus Replication, Antiviral Agents, Up-Regulation, GENE-EXPRESSION, CYTOKINE, QUERCETIN, TYPE-1, MODULATION, Capparis, Freeze Drying, Leukocytes, Mononuclear, Cytokines, Immunologic Factors, Antiviral, Capper spinosa buds, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Immunomodulatory, Peripheral blood mononuclear cells (PBMCs), Cells, Cultured
Abstract

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are common human pathogens that in particular cases can also cause severe problems especially in immunodeficient patients. The present paper reports the antiviral and immunomodulatory properties of a methanolic extract of C. spinosa buds (CAP), rich in flavonoids, including several quercetin and kaempferol glycosides. In particular we have investigated whether the in vitro exposure of human peripheral blood mononuclear cells (PBMCs) to CAP might inhibit the replication of HSV-2 and modulate the induction kinetics of IL-12, TNF-alpha IFN-gamma. Our findings have shown that CAP treatment interferes with HSV-2 replication in PBMCs inhibiting the extracellular virus release upregulating their production of IL-12, IFN-gamma and TNF-alpha. One could speculate that CAP may contribute in improving immune surveillance of PBMCs toward virus infection by up-regulating expression of peculiar proinflammatory cytokines; it should thus be successfully employed for treatment of HSV-2 infections in immunocompromised hosts.

Published
2008

33. THE SEISMIC VULNERABILITY OF SOME AREAS IN THE CITY OF MESSINA (ITALY) OVER THE CENTURIES, FROM AN ANALYSIS OF THE SAFETY REDUCERS TIME VARIATION: PAST EXPERIENCES AND PERSPECTIVES

Author

Ammerata, E. G., Attanasio, M, Belardi, G, Blancato, C, Bonina, F, Bottari, A, Bruno, A, Bucca, D, Damico, M, DE DOMENICO, Domenica, DE LORENZO, M, Denaro, S, DI BELLA, A, Floramo, F, Gueli, F, LA MALFA, G, Marino, A, Marletta, C, Marullo, A, Minutoli, C, Munafo, C, Paino, G, Romeo, M, Russo, V, Sacca, C, Sofi, G, Sorge, A, Spatafora, A, Spatafora, M. R., Teramo, Antonio, Termini, Domenica, Traviglia, D, and Villari, G.

Published
2006

36. Seismic vulnerability evaluation of high seismic risk cities through an analysis of the urban space transformation over the centuries and safety logics

Author

Teramo, Antonio, Termini, Domenica, Bottari, A, DE DOMENICO, Domenica, Marino, A, Sacca', Carmelo, Minutoli, Caterina, Damico, M, Marullo, A, Munaf, C, Ammerata, E. G., Attanasio, M, Belardi, G, Blancato, C, Bonina, F, Bruno, A, Bucca, D, DE LORENZO, M, Denaro, S, DI BELLA, A, Floramo, F, Gueli, F, LA MALFA, G, Marletta, C, Paino, G, Romeo, M, Russo, V, Sofi, G, Sorge, A, Spatafora, A, Spatafora, M. R., Traviglia, D, and Villari, G.

Published
2006

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