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6. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Serna, Almudena de la, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Sojo-Dorado, Jesus, Morales, Isabel, Maldonado, Natalia, Santis, Lucia Valiente de, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Cano, Angela, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Daniel Gumucio, Victor, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Rossolini, Gian Maria, Nica, Maria, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Ramírez, Lina M Parra, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, degli Atti, Marta Luisa Ciofi, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, pasquale, Marta Di, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Reuter, Sandra, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, ancak, Banu, Sahin, Arife, Akalin, Halis, Paniagua-García, María, Bravo-Ferrer, Jose M., Pérez-Galera, Salvador, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Palacios-Baena, Zaira R., Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Cano, Ángela, Reguera, Jose María, Bartoloni, Alessandro, Florescu, Simin-Aysel, Benea, Serban, Asensio, Ángel, Korten, Volkan, Grundmann, Hajo, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodríguez-Baño, Jesús

Published
2024
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7. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Author

de la Serna, Almudena, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Palacios, Zaira, Morales, Isabel, Maldonado, Natalia, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Gumucio, Victor Daniel, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Bartoloni, Alessandro, Rossolini, Gian Maria, Florescu, Simin-Aysel, Nica, Maria, Benea, Serban, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Parra Ramírez, Lina M., Korten, Volkan, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, Ciofi degli Atti, Marta Luisa, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, Di pasquale, Marta, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, Sancak, Banu, Sahin, Arife, Akalin, Halis, Pérez-Galera, Salvador, Bravo-Ferrer, Jose M., Paniagua, María, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Sojo-Dorado, Jesús, Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Reguera, Jose María, Valiente de Santis, Lucía, Torre-Cisneros, Julián, Cano, Ángela, Roilides, Emmanuel, Radulovic, Lili, Kirakli, Cenk, Shaw, Evelyn, Falagas, Matthew E., Pintado, Vicente, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodriguez-Baño, Jesús

Published
2023
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10. The 2021 Dutch Working Party on Antibiotic Policy (SWAB) guidelines for empirical antibacterial therapy of sepsis in adults

Author

Sieswerda, Elske, Bax, Hannelore I., Hoogerwerf, Jacobien J., de Boer, Mark G. J., Boermeester, Marja, Bonten, Marc J. M., Dekker, Douwe, van Wijk, Roy Gerth, Juffermans, Nicole P., Kuindersma, Marnix, van der Linden, Paul D., Melles, Damian C., Pickkers, Peter, Schouten, Jeroen A., Rebel, Jasper R., van Zanten, Arthur R. H., Prins, Jan M., and Wiersinga, W. Joost

Published
2022
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13. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

Author

Peters-Sengers, Hessel, Butler, Joe M., Uhel, Fabrice, Schultz, Marcus J., Bonten, Marc J., Cremer, Olaf L., and Scicluna, Brendon P.

Subjects
Infection -- Patient outcomes -- Comparative analysis, Health care industry
Abstract

Purpose There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit. Methods From the molecular diagnosis and risk stratification of sepsis (MARS) prospective cohort, we measured 16 plasma host response biomarkers reflective of key host response pathways in 621 sepsis patients. In a subgroup (n = 335), blood leukocyte transcriptomes were compared between the sources. Differences in clinical patient profiles and survival were compared in the whole sepsis cohort (n = 2019). Results The plasma biomarker cohort was categorized into sepsis originating from the respiratory tract (n = 334, 53.8%), abdomen (n = 159, 25.6%), urinary tract (n = 44, 7.1%), cardiovascular (n = 41, 6.6%), central nervous system (CNS) (n = 18, 2.9%), or skin (n = 25, 4%). This analysis revealed stronger inflammatory and cytokine responses, loss of vascular integrity and coagulation activation in abdominal sepsis relative to respiratory. Endothelial cell activation was prominent in urinary, cardiovascular and skin infections, while CNS infection was associated with the least host response aberrations. The leukocyte transcriptional response showed the largest overlap between abdominal and pulmonary infections (76% in common); notable differences between the sources were detected regarding hemostasis, cytokine signaling, innate and adaptive immune, and metabolic transcriptional pathways. After adjustment for confounders, the source of infection remained an independent contributor to 30-day mortality (unadjusted p = 0.001, adjusted p = 0.028). Conclusion Sepsis heterogeneity is partly explained by source-specific host response dysregulations and should be considered when selecting patients for trials testing immune modulatory drugs., Author(s): Hessel Peters-Sengers [sup.1] [sup.2], Joe M. Butler [sup.1] [sup.2], Fabrice Uhel [sup.1] [sup.2], Marcus J. Schultz [sup.3] [sup.4] [sup.5] [sup.6], Marc J. Bonten [sup.7] [sup.8], Olaf L. Cremer [sup.9], [...]

Published
2022
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14. Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial

Author

Schweitzer, Valentijn A, van Heijl, Inger, Boersma, Wim G, Rozemeijer, Wouter, Verduin, Kees, Grootenboers, Marco J, Sankatsing, Sanjay U C, van der Bij, Akke K, de Bruijn, Winnie, Ammerlaan, Heidi S M, Overdevest, Ilse, Roorda-van der Vegt, J M Milena, Engel-Dettmers, Elske M, Ayuketah-Ekokobe, Florence E, Haeseker, Michiel B, Dorigo-Zetsma, J Wendelien, van der Linden, Paul D, Boel, C H Edwin, Oosterheert, Jan J, van Werkhoven, Cornelis H, and Bonten, Marc J M

Published
2022
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15. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial

Author

Chochrad, Didier, Dive, Alain, Foret, Frédéric, Simon, Marc, Spapen, Herbert, Creteur, Jacques, Bouckaert, Yves, Biston, Patrick, Bourgeois, Marc, Novacek, Martin, Vymazal, Tomas, Svoboda, Petr, Pachl, Jan, Sramek, Vladimir, Hanauer, Michal, Hruby, Tomas, Balik, Martin, Suchy, Tomas, Lepape, Alain, Argaud, Laurent, Dailler, Frédéric, Desachy, Arnaud, Guitton, Christophe, Mercat, Alain, Meziani, Ferhat, Navellou, Jean-Christophe, Robert, Rene, Souweine, Bertrand, Tadie, Jean-Marc, Maamar, Adel, Annane, Djillali, Tamion, Fabienne, Gros, Antoine, Nseir, Saad, Schwebel, Carole, Francony, Gilles, Lefrant, Jean-Yves, Schneider, Francis, Gründling, Matthias, Motsch, Johann, Reill, Lorenz, Rolfes, Caroline, Welte, Tobias, Cornely, Oliver, Bloos, Frank, Deja, Maria, Schmidt, Katrin, Wappler, Frank, Meier-Hellmann, Andreas, Komnos, Apostolos, Bekos, Vasileios, Koulouras, Vasilios, Soultati, Ioanna, Baltopoulos, Georgios, Filntisis, Georgios, Zakynthinos, Epaminondas, Zakynthinos, Spyros, Pnevmatikos, Ioannis, Krémer, Ildikó, Szentkereszty, Zoltán, Sarkany, Agnes, Marjanek, Zsuzsa, Moura, Pedro, Pintado Delgado, Maria Consuelo, Montejo González, Juan Carlos, Ramirez, Paula, Torres Marti, Antonio, Valia, Juan Carlos, Lorente, Jose, Loza Vazquez, Ana, De Pablo Sanchez, Raúl, Escudero, Dolores, Ferrer Roca, Ricard, Pagani, Jean-Luc, Maggiorini, Marco, François, Bruno, Jafri, Hasan S, Chastre, Jean, Sánchez-García, Miguel, Eggimann, Philippe, Dequin, Pierre-François, Huberlant, Vincent, Viña Soria, Lucia, Boulain, Thierry, Bretonnière, Cédric, Pugin, Jérôme, Trenado, Josep, Hernandez Padilla, Ana Catalina, Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Coenjaerts, Frank E, Ruzin, Alexey, Barraud, Olivier, Timbermont, Leen, Lammens, Christine, Pierre, Vadryn, Wu, Yuling, Vignaud, Julie, Colbert, Susan, Bellamy, Terramika, Esser, Mark T, Dubovsky, Filip, Bonten, Marc J, Goossens, Herman, and Laterre, Pierre-François

Published
2021
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16. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Julius Centrum, Ecraid, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Paniagua-García, María, Bravo-Ferrer, Jose M, Pérez-Galera, Salvador, Kostyanev, Tomislav, de Kraker, Marlieke E A, Feifel, Jan, Palacios-Baena, Zaira R, Schotsman, Joost, Cantón, Rafael, Daikos, George L, Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K, Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Cano, Ángela, Reguera, Jose María, Bartoloni, Alessandro, Florescu, Simin-Aysel, Benea, Serban, Bukarica, Ljiljana, Asensio, Ángel, Korten, Volkan, Grundmann, Hajo, Goossens, Herman, Bonten, Marc J, Gutiérrez-Gutiérrez, Belén, Rodríguez-Baño, Jesús, COMBACTE-CARE-EURECA Team, Julius Centrum, Ecraid, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Paniagua-García, María, Bravo-Ferrer, Jose M, Pérez-Galera, Salvador, Kostyanev, Tomislav, de Kraker, Marlieke E A, Feifel, Jan, Palacios-Baena, Zaira R, Schotsman, Joost, Cantón, Rafael, Daikos, George L, Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K, Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Cano, Ángela, Reguera, Jose María, Bartoloni, Alessandro, Florescu, Simin-Aysel, Benea, Serban, Bukarica, Ljiljana, Asensio, Ángel, Korten, Volkan, Grundmann, Hajo, Goossens, Herman, Bonten, Marc J, Gutiérrez-Gutiérrez, Belén, Rodríguez-Baño, Jesús, and COMBACTE-CARE-EURECA Team

Published
2024

17. Determinants of Systemic SARS-CoV-2-Specific Antibody Responses to Infection and to Vaccination: A Secondary Analysis of Randomised Controlled Trial Data

Author

Infection & Immunity, Epi Infectieziekten Team 1b, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Claus, Juana, Ten Doesschate, Thijs, Taks, Esther, Debisarun, Priya A, Smits, Gaby, van Binnendijk, Rob, van der Klis, Fiona, Verhagen, Lilly M, de Jonge, Marien I, Bonten, Marc J M, Netea, Mihai G, van de Wijgert, Janneke H H M, Infection & Immunity, Epi Infectieziekten Team 1b, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Claus, Juana, Ten Doesschate, Thijs, Taks, Esther, Debisarun, Priya A, Smits, Gaby, van Binnendijk, Rob, van der Klis, Fiona, Verhagen, Lilly M, de Jonge, Marien I, Bonten, Marc J M, Netea, Mihai G, and van de Wijgert, Janneke H H M

Published
2024

18. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

Author

MMB Research line 1, Infection & Immunity, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectious Diseases, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, MMB Onderzoek en Onderwijs, Hendriks, Astrid, Kerkman, Priscilla F, Varkila, Meri R J, Haitsma Mulier, Jelle L G, Ali, Sara, Ten Doesschate, Thijs, van der Vaart, Thomas W, de Haas, Carla J C, Aerts, Piet C, Cremer, Olaf L, Bonten, Marc J M, Nizet, Victor, Liu, George Y, Codée, Jeroen D C, Rooijakkers, Suzan H M, van Strijp, Jos A G, van Sorge, Nina M, MMB Research line 1, Infection & Immunity, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectious Diseases, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, MMB Onderzoek en Onderwijs, Hendriks, Astrid, Kerkman, Priscilla F, Varkila, Meri R J, Haitsma Mulier, Jelle L G, Ali, Sara, Ten Doesschate, Thijs, van der Vaart, Thomas W, de Haas, Carla J C, Aerts, Piet C, Cremer, Olaf L, Bonten, Marc J M, Nizet, Victor, Liu, George Y, Codée, Jeroen D C, Rooijakkers, Suzan H M, van Strijp, Jos A G, and van Sorge, Nina M

Published
2024

19. Acute kidney injury in Staphylococcus aureus bacteraemia: a recurrent events analysis

Author

Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Buis, David T P, van der Vaart, Thomas W, Mohan, Asna, Prins, Jan M, van der Meer, Jan T M, Bonten, Marc J M, Jakulj, Lily, van Werkhoven, Cornelis H, Sigaloff, Kim C E, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, Buis, David T P, van der Vaart, Thomas W, Mohan, Asna, Prins, Jan M, van der Meer, Jan T M, Bonten, Marc J M, Jakulj, Lily, van Werkhoven, Cornelis H, and Sigaloff, Kim C E

Published
2024

20. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

Van Boven, Michiel, van Dorp, Christiaan H., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J., Kretzschmar, Mirjam E., Bruijning-Verhagen, Patricia, Van Boven, Michiel, van Dorp, Christiaan H., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J., Kretzschmar, Mirjam E., and Bruijning-Verhagen, Patricia

Abstract

Household studies provide an efficient means to study transmission of infectious diseases, enabling estimation of susceptibility and infectivity by person-type. A main inclusion criterion in such studies is usually the presence of an infected person. This precludes estimation of the hazards of pathogen introduction into the household. Here we estimate age- and time-dependent household introduction hazards together with within household transmission rates using data from a prospective household-based study in the Netherlands. A total of 307 households containing 1, 209 persons were included from August 2020 until March 2021. Follow-up of households took place between August 2020 and August 2021 with maximal follow-up per household mostly limited to 161 days. Almost 1 out of 5 households (59/307) had evidence of an introduction of SARS-CoV-2. We estimate introduction hazards and within-household transmission rates in our study population with penalized splines and stochastic epidemic models, respectively. The estimated hazard of introduction of SARS-CoV-2 in the households was lower for children (0-12 years) than for adults (relative hazard: 0.62; 95%CrI: 0.34-1.0). Estimated introduction hazards peaked in mid October 2020, mid December 2020, and mid April 2021, preceding peaks in hospital admissions by 1-2 weeks. Best fitting transmission models included increased infectivity of children relative to adults and adolescents, such that the estimated child-to-child transmission probability (0.62; 95%CrI: 0.40-0.81) was considerably higher than the adult-to-adult transmission probability (0.12; 95%CrI: 0.057-0.19). Scenario analyses indicate that vaccination of adults can strongly reduce household infection attack rates and that adding adolescent vaccination offers limited added benefit.

Published
2024

21. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, van der Poll, Tom, Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, and van der Poll, Tom

Published
2024

22. Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis

Author

Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, and Cremer, Olaf L

Published
2024

23. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

Author

Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, Bruijning-Verhagen, Patricia, Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Epi Infectieziekten Team 2, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, van Boven, Michiel, van Dorp, Christiaan H, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie, Duijts, Liesbeth, Fourie, Elandri, Sluiter-Post, Judith, van Houten, Marlies A, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Eggink, Dirk, de Hoog, Marieke, Boom, Trisja, Wildenbeest, Joanne, Bont, Louis, Rozhnova, Ganna, Bonten, Marc J, Kretzschmar, Mirjam E, and Bruijning-Verhagen, Patricia

Published
2024

24. The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence

Author

Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, van der Vaart, Thomas W, Prins, Jan M, Goorhuis, Abraham, Lemkes, Bregtje A, Sigaloff, Kim C E, Spoorenberg, Veroniek, Stijnis, Cornelis, Bonten, Marc J M, van der Meer, Jan T M, Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, van der Vaart, Thomas W, Prins, Jan M, Goorhuis, Abraham, Lemkes, Bregtje A, Sigaloff, Kim C E, Spoorenberg, Veroniek, Stijnis, Cornelis, Bonten, Marc J M, and van der Meer, Jan T M

Published
2024

25. Biomarker guided antibiotic stewardship in community acquired pneumonia: A randomized controlled trial.

Author

Duijkers, Ruud, Prins, Hendrik J., Kross, Martijn, Snijders, Dominic, van den Berg, Jan W. K., Werkman, Gwendolyn M., van der Veen, Nynke, Schoorl, Marianne, Bonten, Marc J. M., van Werkhoven, Cornelis H., and Boersma, Wim G.

Subjects
COMMUNITY-acquired pneumonia, C-reactive protein, RANDOMIZED controlled trials, ANTIMICROBIAL stewardship, TEACHING hospitals
Abstract

Background: In community-acquired pneumonia (CAP), the role of biomarkers to shorten duration of antibiotic treatment has not been firmly established. We assessed the effectiveness of active feedback of treatment algorithms based on procalcitonin (PCT) and C-reactive protein (CRP), compared to standard care, on the duration of antibiotic treatment in patients hospitalized with community-acquired pneumonia (CAP) in non-ICU wards. Methods and findings: We performed a randomised, open label, parallel group, multi-centre trial in 3 Dutch teaching hospitals. Treatment was guided by a PCT algorithm, CRP algorithm or standard care. Participants were recruited by a member of the study team and randomised at day 2–3 of admission in a 1:1:1 ratio. Treatment was discontinued upon predefined thresholds of biomarkers that were assessed on admission, day 4 and days 5–7 if indicated. The primary outcome was total days on antibiotic treatment until day 30. In total 468 participants were included in this study. The median days on antibiotics (IQR) was 7 (IQR 7–10) in the control group, 4 (IQR 3–7) in the CRP group (rate ratio (RR) of 0.70, 95% CI 0.61–0.82 compared to standard care; p <0.001), and 5.5 (IQR 3–9) in the PCT group (RR of 0.78, 95% CI 0.68–0.89 compared to standard care; p <0.001). New antibiotics within the first 30 days were prescribed to 24, 23 and 35 patients in standard care, CRP and PCT groups, respectively. The hazard ratio for a new prescription in patients in the PCT group compared to standard care 1.63 (CI 0.97–2.75; p = 0.06). No difference in time to clinical stability or length of stay was found. Conclusions: A strategy of feedback of CRP-guided and PCT-guided treatment algorithms reduced the number of days on antibiotic in the first 30 days after hospital admission in non-ICU wards for CAP. The study was not powered to determine safety of shortening duration of antibiotic treatment. (NCT01964495). [ABSTRACT FROM AUTHOR]

Published
2024
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26. Determinants of Systemic SARS-CoV-2-Specific Antibody Responses to Infection and to Vaccination: A Secondary Analysis of Randomised Controlled Trial Data.

Author

Claus, Juana, ten Doesschate, Thijs, Taks, Esther, Debisarun, Priya A., Smits, Gaby, van Binnendijk, Rob, van der Klis, Fiona, Verhagen, Lilly M., de Jonge, Marien I., Bonten, Marc J. M., Netea, Mihai G., and van de Wijgert, Janneke H. H. M.

Subjects
MEDICAL personnel, ANTIBODY formation, RANDOMIZED controlled trials, POST-acute COVID-19 syndrome, COVID-19
Abstract

SARS-CoV-2 infections elicit antibodies against the viral spike (S) and nucleocapsid (N) proteins; COVID-19 vaccines against the S-protein only. The BCG-Corona trial, initiated in March 2020 in SARS-CoV-2-naïve Dutch healthcare workers, captured several epidemic peaks and the introduction of COVID-19 vaccines during the one-year follow-up. We assessed determinants of systemic anti-S1 and anti-N immunoglobulin type G (IgG) responses using trial data. Participants were randomised to BCG or placebo vaccination, reported daily symptoms, SARS-CoV-2 test results, and COVID-19 vaccinations, and donated blood for SARS-CoV-2 serology at two time points. In the 970 participants, anti-S1 geometric mean antibody concentrations (GMCs) were much higher than anti-N GMCs. Anti-S1 GMCs significantly increased with increasing number of immune events (SARS-CoV-2 infection or COVID-19 vaccination): 104.7 international units (IU)/mL, 955.0 IU/mL, and 2290.9 IU/mL for one, two, and three immune events, respectively (p < 0.001). In adjusted multivariable linear regression models, anti-S1 and anti-N log10 concentrations were significantly associated with infection severity, and anti-S1 log10 concentration with COVID-19 vaccine type/dose. In univariable models, anti-N log10 concentration was also significantly associated with acute infection duration, and severity and duration of individual symptoms. Antibody concentrations were not associated with long COVID or long-term loss of smell/taste. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Anticoagulant interventions in hospitalized patients with COVID‐19: A scoping review of randomized controlled trials and call for international collaboration

Author

Tritschler, Tobias, Mathieu, Marie‐Eve, Skeith, Leslie, Rodger, Marc, Middeldorp, Saskia, Brighton, Timothy, Sandset, Per Morten, Kahn, Susan R., Angus, Derek C., Blondon, Marc, Bonten, Marc J., Cattaneo, Marco, Cushman, Mary, Derde, Lennie P.G., DeSancho, Maria T., Diehl, Jean‐Luc, Goligher, Ewan, Jilma, Bernd, Jüni, Peter, Lawler, Patrick R., Marietta, Marco, Marshall, John C., McArthur, Colin, Miranda, Carlos Henrique, Mirault, Tristan, Morici, Nuccia, Perepu, Usha, Schörgenhofer, Christian, Sholzberg, Michelle, Spyropoulos, Alex C., Webb, Steve A., Zarychanski, Ryan, Zuily, Stéphane, and Le Gal, Grégoire

Published
2020
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29. Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial

Author

Maechler, Friederike, Schwab, Frank, Hansen, Sonja, Fankhauser, Carolina, Harbarth, Stephan, Huttner, Benedikt D, Diaz-Agero, Cristina, Lopez, Nieves, Canton, Rafael, Ruiz-Garbajosa, Patricia, Blok, Hetty, Bonten, Marc J, Kloosterman, Fieke, Schotsman, Joost, Cooper, Ben S, Behnke, Michael, Golembus, Jennifer, Kola, Axel, and Gastmeier, Petra

Published
2020
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30. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Paniagua-García, María, primary, Bravo-Ferrer, Jose M., additional, Pérez-Galera, Salvador, additional, Kostyanev, Tomislav, additional, de Kraker, Marlieke E.A., additional, Feifel, Jan, additional, Palacios-Baena, Zaira R., additional, Schotsman, Joost, additional, Cantón, Rafael, additional, Daikos, George L., additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Tan, Lionel K., additional, Raka, Lul, additional, Hristea, Adriana, additional, Viale, Pierluigi, additional, Akova, Murat, additional, Cano, Ángela, additional, Reguera, Jose María, additional, Bartoloni, Alessandro, additional, Florescu, Simin-Aysel, additional, Benea, Serban, additional, Bukarica, Ljiljana, additional, Asensio, Ángel, additional, Korten, Volkan, additional, Grundmann, Hajo, additional, Goossens, Herman, additional, Bonten, Marc J., additional, Gutiérrez-Gutiérrez, Belén, additional, Rodríguez-Baño, Jesús, additional, Serna, Almudena de la, additional, Monteau, Sophie, additional, Palomo, Virginia, additional, Soriano, Elena, additional, Gutierrez, David, additional, Moreno, Elisa, additional, Sojo-Dorado, Jesus, additional, Morales, Isabel, additional, Maldonado, Natalia, additional, Santis, Lucia Valiente de, additional, Ciezar, Antonio Plata, additional, Ruiz Mesa, Juan Diego, additional, Diaz, Beatriz Sobrino, additional, Gomez, Ignacio Marquez, additional, Camacho, Ines Perez, additional, Cano, Angela, additional, Frutos-Adame, Azahara, additional, Guzman-Puche, Julia, additional, Gracia-Ahufinger, Irene, additional, Perez-Nadales, Elena, additional, Torre-Gimenez, Julian, additional, Pyrpasopoulou, Athina, additional, Iosifidis, Elias, additional, Chorafa, Elsa, additional, Radovanovic, Ivana, additional, Petrovic, Sladjana, additional, Cvetkovi, Slavica, additional, Melentijevic, Srdjan-Sanja, additional, Bicmen, Can, additional, Senol, Gunes, additional, Tubau, Fe, additional, Camara, Jordi, additional, Daniel Gumucio, Victor, additional, Bassoulis, Dimitris, additional, Deliolanis, John, additional, Pitiriga, Vassiliki Ch., additional, Triarides, Nikolaos, additional, Argiti, Efstathia, additional, Legakis, Nikolaos J., additional, Margarita, Kyriakidou, additional, Gijón-Cordero, Desirée, additional, Ruiz-Garbajosa, Patricia, additional, Rossolini, Gian Maria, additional, Nica, Maria, additional, Talapan, Daniela, additional, Medić, Deana, additional, Prijić, Sanja Maričić, additional, Caballero, Mireia Cantero, additional, Ramírez, Lina M Parra, additional, Bilgin, Hüseyin, additional, Dalekos, George N., additional, Stefos, Aggelos, additional, Spyridis, Nikolaos, additional, Michos, Athanasios, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Petrosillo, Nicola, additional, Dicaro, Antonio, additional, Landini, Maria Paola, additional, degli Atti, Marta Luisa Ciofi, additional, Masanovic, Mileva, additional, Matkovic, Dusan, additional, Tsiodras, Sotirios, additional, Blasi, Francesco, additional, pasquale, Marta Di, additional, Viscoli, Claudio, additional, Vata, Andrei, additional, Dorneanu, Olivia, additional, Kapisyzi, Perlat, additional, Vince, Adriana, additional, Tsigou, Evdoxia, additional, Maltezos, Efstratios, additional, Komnos, Apostolos, additional, Gogos, Charalampos, additional, Franzetti, Fabio, additional, Antonelli, Massimo, additional, Lupse, Mihaela, additional, Corneci, Dan, additional, Tomescu, Dana, additional, Georgescu, Anca, additional, Mitrović, Goran, additional, Krstić, Nataša Lukić, additional, Kurti, Arsim, additional, Reuter, Sandra, additional, Díaz-Pollán, Beatriz, additional, Sabater, Julia Origüen, additional, Muñoz, Patricia, additional, Azap, Alpay, additional, ancak, Banu, additional, Sahin, Arife, additional, and Akalin, Halis, additional

Published
2024
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32. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Chouchane, Osoul, primary, Schuurman, Alex R., additional, Reijnders, Tom D. Y., additional, Peters-Sengers, Hessel, additional, Butler, Joe M, additional, Uhel, Fabrice, additional, Schultz, Marcus J, additional, Bonten, Marc J., additional, Cremer, Olaf L, additional, Calfee, Carolyn S, additional, Matthay, Michael A., additional, Langley, Raymond J, additional, Alipanah-Lechner, Narges, additional, Kingsmore, Stephen F, additional, Rogers, Angela, additional, Weeghel, Michel van, additional, Vaz, Frédéric M., additional, and van der Poll, Tom, additional

Published
2024
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37. Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study

Author

Uhel, Fabrice, Peters-Sengers, Hessel, Falahi, Fahimeh, Scicluna, Brendon P., van Vught, Lonneke A., Bonten, Marc J., and Cremer, Olaf L.

Subjects
Mortality -- Netherlands -- Analysis, Infection -- Research -- Health aspects -- Analysis, Health care industry, University of Amsterdam
Abstract

Purpose Sepsis is the most frequent cause of acute kidney injury (AKI). The 'Acute Disease Quality Initiative Workgroup' recently proposed new definitions for AKI, classifying it as transient or persistent. We investigated the incidence, mortality, and host response aberrations associated with transient and persistent AKI in sepsis patients. Methods A total of 1545 patients admitted with sepsis to 2 intensive care units in the Netherlands were stratified according to the presence (defined by any urine or creatinine RIFLE criterion within the first 48 h) and evolution of AKI (with persistent defined as remaining > 48 h). We determined 30-day mortality by logistic regression adjusting for confounding variables and analyzed 16 plasma biomarkers reflecting pathways involved in sepsis pathogenesis (n = 866) and blood leukocyte transcriptomes (n = 392). Results AKI occurred in 37.7% of patients, of which 18.4% was transient and 81.6% persistent. On admission, patients with persistent AKI had higher disease severity scores and more frequently had severe (injury or failure) RIFLE AKI stages than transient AKI patients. Persistent AKI, but not transient AKI, was associated with increased mortality by day 30 and up to 1 year. Persistent AKI was associated with enhanced and sustained inflammatory and procoagulant responses during the first 4 days, and a more severe loss of vascular integrity compared with transient AKI. Baseline blood gene expression showed minimal differences with respect to the presence or evolution of AKI. Conclusion Persistent AKI is independently associated with sepsis mortality, as well as with sustained inflammatory and procoagulant responses, and loss of vascular integrity as compared with transient AKI., Author(s): Fabrice Uhel [sup.1], Hessel Peters-Sengers [sup.1], Fahimeh Falahi [sup.1], Brendon P. Scicluna [sup.1] [sup.2], Lonneke A. van Vught [sup.1], Marc J. Bonten [sup.3] [sup.4], Olaf L. Cremer [sup.5], Marcus [...]

Published
2020
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38. Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review

Author

Wittekamp, Bastiaan H. J., Oostdijk, Evelien A. N., Cuthbertson, Brian H., Brun-Buisson, Christian, and Bonten, Marc J. M.

Subjects
Drug resistance in microorganisms -- Prevention, Infection -- Prevention, Antibiotics -- Health aspects, Hospital patients -- Health aspects, Health care industry
Abstract

Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed more than 30 years ago, and that is currently considered standard of care in the Netherlands, but only used sporadically in ICUs in other countries. In this narrative review, we first describe the rationale of the individual components of SDD and then review the evidence base for patient-centered outcomes, where we distinguish ICUs with low prevalence of antibiotic resistance from ICUs with moderate-high prevalence of resistance. In settings with low prevalence of antibiotic resistance, SDD has been associated with improved patient outcome in three cluster-randomized studies. These benefits were not confirmed in a large international cluster-randomized study in settings with moderate-to-high prevalence of antibiotic resistance. There is no evidence that SDD increases antibiotic resistance. We end with future directions for research., Author(s): Bastiaan H. J. Wittekamp [sup.1], Evelien A. N. Oostdijk [sup.1], Brian H. Cuthbertson [sup.2], Christian Brun-Buisson [sup.3], Marc J. M. Bonten [sup.4] [sup.5] Author Affiliations: (1) Department of Intensive [...]

Published
2020
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39. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study

Author

Bonten, Marc, Bootsma, Martin, de Brauwer, Els, Bruijning-Verhagen, Patricia, Buiting, Anton, Diederen, Bram, van Elzakker, Erika, Friedrich, Alexander, Hopman, Joost, Kampinga, Greetje, van Keulen, Peter, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, al Naiemi, Nashwan, Oudhuis, Guy, Raangs, Erwin, Rosema, Sigrid, Rossen, John, Ruijs, Gijs, Savelkoul, Paul, Troelstra, Annet, Vandenbroucke-Grauls, Christina, Verduin, Kees, Verhulst, Carlo, Vos, Margreet, Voss, Andreas, Willems, Rob, Willemsen, Ina, Kluytmans-van den Bergh, Marjolein F Q, Bruijning-Verhagen, Patricia C J, Vandenbroucke-Grauls, Christina M J E, de Brauwer, Els I G B, Buiting, Anton G M, Diederen, Bram M, van Elzakker, Erika P M, Friedrich, Alex W, Rossen, John W A, Ruijs, Gijs J H M, Savelkoul, Paul H M, Vos, Margreet C, Bonten, Marc J M, and Kluytmans, Jan A J W

Published
2019
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42. The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence.

Author

Vaart, Thomas W van der, Prins, Jan M, Goorhuis, Abraham, Lemkes, Bregtje A, Sigaloff, Kim C E, Spoorenberg, Veroniek, Stijnis, Cornelis, Bonten, Marc J M, and Meer, Jan T M van der

Subjects
ANTIBIOTICS, RISK assessment, PREDICTIVE tests, STAPHYLOCOCCAL diseases, RESEARCH funding, BACTEREMIA, RESEARCH evaluation, METHICILLIN-resistant staphylococcus aureus, DISEASE prevalence, DIAGNOSTIC errors, TREATMENT duration, TREATMENT effectiveness, MULTIVARIATE analysis, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, CONFIDENCE intervals, DATA analysis software, DISEASE risk factors
Abstract

Introduction Recommended duration of antibiotic treatment of Staphylococcus aureus bacteremia (SAB) is frequently based on distinguishing uncomplicated and complicated SAB, and several risk factors at the onset of infection have been proposed to define complicated SAB. Predictive values of risk factors for complicated SAB have not been validated, and consequences of their use on antibiotic prescriptions are unknown. Methods In a prospective cohort, patients with SAB were categorized as complicated or uncomplicated through adjudication (reference definition). Associations and predictive values of 9 risk factors were determined, compared with the reference definition, as was accuracy of Infectious Diseases Society of America (IDSA) criteria that include 4 risk factors, and the projected consequences of applying IDSA criteria on antibiotic use. Results Among 490 patients, 296 (60%) had complicated SAB. In multivariable analysis, persistent bacteremia (odds ratio [OR], 6.8; 95% confidence interval [CI], 3.9–12.0), community acquisition of SAB (OR, 2.9; 95% CI, 1.9–4.7) and presence of prosthetic material (OR, 2.3; 95% CI, 1.5–3.6) were associated with complicated SAB. Presence of any of the 4 risk factors in the IDSA definition of complicated SAB had a positive predictive value of 70.9% (95% CI, 65.5–75.9) and a negative predictive value of 57.5% (95% CI, 49.1–64.8). Compared with the reference, IDSA criteria yielded 24 (5%) false-negative and 90 (18%) false-positive classifications of complicated SAB. Median duration of antibiotic treatment of these 90 patients was 16 days (interquartile range, 14–19), all with favorable clinical outcome. Conclusions Risk factors have low to moderate predictive value to identify complicated SAB and their use may lead to unnecessary prolonged antibiotic use. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Late Breaking Abstract - The blood transcriptional response in ICU-acquired pneumonia

Author

de Brabander, Justin, primary, Michels, Erik H. A., additional, Butler, Joe M., additional, Reijnders, Tom D. Y., additional, Van Engelen, Tjitske S. R., additional, Leite, Giuseppe G. F., additional, Paling, Fleur P., additional, Bonten, Marc J. M., additional, Timbermont, Leen, additional, Malhotra-Kumar, Surbhi, additional, Kluytmans, Jan A. J. W., additional, Peters-Sengers, Hessel, additional, and Van Der Poll, Tom, additional

Published
2023
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46. Antibiotic Resistance and the Risk of Recurrent Bacteremia

Author

Infectious Diseases Surveillance Information System–Antimicrobial Resistance (ISIS-AR) Study Group, Woudt, Sjoukje H. S., de Greeff, Sabine C., Schoffelen, Annelot F., Vlek, Anne L. M., and Bonten, Marc J. M.

Published
2018

50. Reply to Lipcsey

Author

Ong, David S. Y., Bonten, Marc J. M., and Cremer, Olaf L.

Published
2018

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