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1. Sensory over‐responsivity and atypical neural responses to socially relevant stimuli in autism.

Author

Than, A., Patterson, G., Cummings, K. K., Jung, J., Cakar, M. E., Abbas, L., Bookheimer, S. Y., Dapretto, M., and Green, S. A.

Abstract

Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over‐responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically‐developing (TD) youth, aged 8.6–18.0 years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory‐motor regions to socially‐relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR. Lay Summary: In this study, we used functional magnetic resonance imaging (fMRI) to examine brain responses to aversive sensory stimuli with and without social relevance in youth with autism spectrum disorder (ASD) and typically‐developing (TD) youth. TD youth showed greater neural responses to social compared with nonsocial sensory inputs, whereas the opposite was true in ASD youth. Results suggest that compared with TD youth, ASD youth (particularly those with more severe sensory over‐responsivity symptoms) attend more to the level of aversiveness rather than to the social relevance of sensory input. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Anorexia nervosa and body dysmorphic disorder are associated with abnormalities in processing visual information

Author

Li, W, Lai, TM, Bohon, C, Loo, SK, McCurdy, D, Strober, M, Bookheimer, S, and Feusner, J

Subjects
Biological Psychology, Psychology, Anorexia, Mental Health, Nutrition, Eating Disorders, Eye Disease and Disorders of Vision, Neurosciences, Clinical Research, Mental health, Adolescent, Adult, Anorexia Nervosa, Body Dysmorphic Disorders, Evoked Potentials, Female, Humans, Los Angeles, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Perceptual Distortion, Psychiatric Status Rating Scales, Vision Disorders, Visual Perception, Young Adult, Dorsal/ventral visual streams, electroencephalography, event-related potential, face processing, house processing, joint ICA, Public Health and Health Services, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) are characterized by distorted body image and are frequently co-morbid with each other, although their relationship remains little studied. While there is evidence of abnormalities in visual and visuospatial processing in both disorders, no study has directly compared the two. We used two complementary modalities--event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI)--to test for abnormal activity associated with early visual signaling.MethodWe acquired fMRI and ERP data in separate sessions from 15 unmedicated individuals in each of three groups (weight-restored AN, BDD, and healthy controls) while they viewed images of faces and houses of different spatial frequencies. We used joint independent component analyses to compare activity in visual systems.ResultsAN and BDD groups demonstrated similar hypoactivity in early secondary visual processing regions and the dorsal visual stream when viewing low spatial frequency faces, linked to the N170 component, as well as in early secondary visual processing regions when viewing low spatial frequency houses, linked to the P100 component. Additionally, the BDD group exhibited hyperactivity in fusiform cortex when viewing high spatial frequency houses, linked to the N170 component. Greater activity in this component was associated with lower attractiveness ratings of faces.ConclusionsResults provide preliminary evidence of similar abnormal spatiotemporal activation in AN and BDD for configural/holistic information for appearance- and non-appearance-related stimuli. This suggests a common phenotype of abnormal early visual system functioning, which may contribute to perceptual distortions.

Published
2015

4. The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

Author

Di Martino, A, Yan, C-G, Li, Q, Denio, E, Castellanos, F X, Alaerts, K, Anderson, J S, Assaf, M, Bookheimer, S Y, Dapretto, M, Deen, B, Delmonte, S, Dinstein, I, Ertl-Wagner, B, Fair, D A, Gallagher, L, Kennedy, D P, Keown, C L, Keysers, C, Lainhart, J E, Lord, C, Luna, B, Menon, V, Minshew, N J, Monk, C S, Mueller, S, Müller, R-A, Nebel, M B, Nigg, J T, O'Hearn, K, Pelphrey, K A, Peltier, S J, Rudie, J D, Sunaert, S, Thioux, M, Tyszka, J M, Uddin, L Q, Verhoeven, J S, Wenderoth, N, Wiggins, J L, Mostofsky, S H, and Milham, M P

Published
2014
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9. Temporal lobe regions essential for preserved picture naming after left temporal epilepsy surgery.

Author

Binder, JR, Tong, J-Q, Pillay, SB, Conant, LL, Humphries, CJ, Raghavan, M, Mueller, WM, Busch, RM, Allen, L, Gross, WL, Anderson, CT, Carlson, CE, Lowe, MJ, Langfitt, JT, Tivarus, ME, Drane, DL, Loring, DW, Jacobs, M, Morgan, VL, Allendorfer, JB, Szaflarski, JP, Bonilha, L, Bookheimer, S, Grabowski, T, Vannest, J, Swanson, SJ, fMRI in Anterior Temporal Epilepsy Surgery (FATES) study, Binder, JR, Tong, J-Q, Pillay, SB, Conant, LL, Humphries, CJ, Raghavan, M, Mueller, WM, Busch, RM, Allen, L, Gross, WL, Anderson, CT, Carlson, CE, Lowe, MJ, Langfitt, JT, Tivarus, ME, Drane, DL, Loring, DW, Jacobs, M, Morgan, VL, Allendorfer, JB, Szaflarski, JP, Bonilha, L, Bookheimer, S, Grabowski, T, Vannest, J, Swanson, SJ, and fMRI in Anterior Temporal Epilepsy Surgery (FATES) study

Abstract

OBJECTIVE: To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. METHODS: Pre- and postoperative brain magnetic resonance imaging data and picture naming (Boston Naming Test) scores were obtained prospectively from 59 people with drug-resistant left temporal lobe epilepsy. All patients had left hemisphere language dominance at baseline and underwent surgical resection or ablation in the left temporal lobe. Postoperative naming assessment occurred approximately 7 months after surgery. Surgical lesions were mapped to a standard template, and the relationship between presence or absence of a lesion and the degree of naming decline was tested at each template voxel while controlling for effects of overall lesion size. RESULTS: Patients declined by an average of 15% in their naming score, with wide variation across individuals. Decline was significantly related to damage in a cluster of voxels in the ventral temporal lobe, located mainly in the fusiform gyrus approximately 4-6 cm posterior to the temporal tip. Extent of damage to this region explained roughly 50% of the variance in outcome. Picture naming decline was not related to hippocampal or temporal pole damage. SIGNIFICANCE: The results provide the first statistical map relating lesion location in left temporal lobe epilepsy surgery to picture naming decline, and they support previous observations of transient naming deficits from electrical stimulation in the basal temporal cortex. The critical lesion is relatively posterior and could be avoided in many patients undergoing left temporal lobe surgery for intractable epilepsy.

Published
2020

24. Baseline brain function in the preadolescents of the ABCD Study

Author

Chaarani, B., Hahn, S., Allgaier, N., Adise, S., Owens, M. M., Juliano, A. C., Yuan, D. K., Loso, H., Ivanciu, A., Albaugh, M. D., Dumas, J., Mackey, S., Laurent, J., Ivanova, M., Hagler, D. J., Cornejo, M. D., Hatton, S., Agrawal, A., Aguinaldo, L., Ahonen, L., Aklin, W., Anokhin, A. P., Arroyo, J., Avenevoli, S., Babcock, D., Bagot, K., Baker, F. C., Banich, M. T., Barch, D. M., Bartsch, H., Baskin-Sommers, A., Bjork, J. M., Blachman-Demner, D., Bloch, M., Bogdan, R., Bookheimer, S. Y., Breslin, F., Brown, S., Calabro, F. J., Calhoun, V., Casey, B. J., Chang, L., Clark, D. B., Cloak, C., Constable, R. T., Constable, K., Corley, R., Cottler, L. B., Coxe, S., Dagher, R. K., Dale, A. M., Dapretto, M., Delcarmen-Wiggins, R., Dick, A. S., Do, E. K., Dosenbach, N. U. F., Dowling, G. J., Edwards, S., Ernst, T. M., Fair, D. A., Fan, C. C., Feczko, E., Feldstein-Ewing, S. W., Florsheim, P., Foxe, J. J., Freedman, E. G., Friedman, N. P., Friedman-Hill, S., Fuemmeler, B. F., Galvan, A., Gee, D. G., Giedd, J., Glantz, M., Glaser, P., Godino, J., Gonzalez, M., Gonzalez, R., Grant, S., Gray, K. M., Haist, F., Harms, M. P., Hawes, S., Heath, A. C., Heeringa, S., Heitzeg, M. M., Hermosillo, R., Herting, M. M., Hettema, J. M., Hewitt, J. K., Heyser, C., Hoffman, E., Howlett, K., Huber, R. S., Huestis, M. A., Hyde, L. W., Iacono, W. G., Infante, M. A., Irfanoglu, O., Isaiah, A., Iyengar, S., Jacobus, J., James, R., Jean-Francois, B., Jernigan, T., Karcher, N. R., Kaufman, A., Kelley, B., Kit, B., Ksinan, A., Kuperman, J., Laird, A. R., Larson, C., LeBlanc, K., Lessov-Schlagger, C., Lever, N., Lewis, D. A., Lisdahl, K., Little, A. R., Lopez, M., Luciana, M., Luna, B., Madden, P. A., Maes, H. H., Makowski, C., Marshall, A. T., Mason, M. J., Matochik, J., McCandliss, B. D., McGlade, E., Montoya, I., Morgan, G., Morris, A., Mulford, C., Murray, P., Nagel, B. J., Neale, M. C., Neigh, G., Nencka, A., Noronha, A., Nixon, S. J., Palmer, C. E., Pariyadath, V., Paulus, M. P., Pelham, W. E., Pfefferbaum, D., Pierpaoli, C., Prescot, A., Prouty, D., Puttler, L. I., Rajapaske, N., Rapuano, K. M., Reeves, G., Renshaw, P. F., Riedel, M. C., Rojas, P., de la Rosa, M., Rosenberg, M. D., Ross, M. J., Sanchez, M., Schirda, C., Schloesser, D., Schulenberg, J., Sher, K. J., Sheth, C., Shilling, P. D., Simmons, W. K., Sowell, E. R., Speer, N., Spittel, M., Squeglia, L. M., Sripada, C., Steinberg, J., Striley, C., Sutherland, M. T., Tanabe, J., Tapert, S. F., Thompson, W., Tomko, R. L., Uban, K. A., Vrieze, S., Wade, N. E., Watts, R., Weiss, S., Wiens, B. A., Williams, O. D., Wilbur, A., Wing, D., Wolff-Hughes, D., Yang, R., Yurgelun-Todd, D. A., Zucker, R. A., Potter, A., and Garavan, H. P.

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study®is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N= 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N= 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N= 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.

Published
2021
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26. Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging

Author

Ercoli, L. M., Small, G. W, Siddarth, P., Kepe, V., Huang, S-C., Miller, K. J., Lavretsky, H., Bookheimer, S. Y., Barrio, J. R., and Silverman, D. H. S.

Subjects
Aged, 80 and over, Male, Neurofibrillary Tangles, Plaque, Amyloid, Middle Aged, Risk Assessment, Article, Fluorodeoxyglucose F18, Risk Factors, Cerebellum, Positron-Emission Tomography, Nitriles, Cluster Analysis, Humans, Cognitive Dysfunction, Dementia, Female, Radiopharmaceuticals, Aged
Abstract

In a previous study, positron emission tomography (PET) with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles in vitro, identified three subgroups of non-demented subjects according to FDDNP binding patterns: low global (LG) binding; high frontal, parietal, medial temporal binding (HF/PA); and high medial and lateral temporal and posterior cingulate (HT/PC) binding. In this follow-up investigation, we compared 2-deoxy-2-[F-18]fluoro- d-glucose (FDG)-PET cerebral metabolic patterns in the three FDDNP-PET binding subgroups.Fifty-four subjects with normal aging (N = 28) or amnestic forms of mild cognitive impairment (N = 26) underwent FDDNP-PET and FDG-PET scanning. Subjects in the LG, HF/PA, and HT/PC FDDNP subgroups were compared according to visual ratings, statistical parametric mapping, and automated region of interest analyses of their FDG-PET data.The FDDNP-PET subgroups demonstrated different glucose metabolic patterns according to visual ratings, region of interest, and statistical parametric mapping analyses of FDG-PET data. The LG FDDNP subgroup showed no areas of significant hypometabolism relative to the other subgroups and had low Alzheimer's disease risk by FDG-PET standards. The HF/PA FDDNP subgroup demonstrated hypometabolism in bilateral inferior parietal/parietotemporal, bilateral posterior cingulate, perisylvian, mid-temporal gyrus, and dorsolateral prefrontal regions, which is a pattern suggestive of high Alzheimer's disease risk. The HT/PC FDDNP subgroup demonstrated heterogeneous FDG-PET patterns with predominant anterior frontal and anterior temporal hypometabolism, suggestive of mixed etiologies, including fronto-temporal dementia risk.The FDG-PET data provided independent validation that different patterns of FDDNP-PET binding in non-demented individuals may be associated with differential dementia risk.

Published
2012

29. The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

Author

Di Martino, A, primary, Yan, C-G, additional, Li, Q, additional, Denio, E, additional, Castellanos, F X, additional, Alaerts, K, additional, Anderson, J S, additional, Assaf, M, additional, Bookheimer, S Y, additional, Dapretto, M, additional, Deen, B, additional, Delmonte, S, additional, Dinstein, I, additional, Ertl-Wagner, B, additional, Fair, D A, additional, Gallagher, L, additional, Kennedy, D P, additional, Keown, C L, additional, Keysers, C, additional, Lainhart, J E, additional, Lord, C, additional, Luna, B, additional, Menon, V, additional, Minshew, N J, additional, Monk, C S, additional, Mueller, S, additional, Müller, R-A, additional, Nebel, M B, additional, Nigg, J T, additional, O'Hearn, K, additional, Pelphrey, K A, additional, Peltier, S J, additional, Rudie, J D, additional, Sunaert, S, additional, Thioux, M, additional, Tyszka, J M, additional, Uddin, L Q, additional, Verhoeven, J S, additional, Wenderoth, N, additional, Wiggins, J L, additional, Mostofsky, S H, additional, and Milham, M P, additional

Published
2013
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30. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study

Author

Hertz-Pannier, L., Gaillard, W. D., Mott, S. H., Charles Andre Cuenod, Bookheimer, S. Y., Weinstein, S., Conry, J., Papero, P. H., Schiff, S. J., Le Bihan, D., Theodore, W. H., Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Department of Health and Human Services, National Institutes of Health ( NIH ), Méthodes d'imagerie des échanges transcapillaires ( LRI ), IFR94-Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire de Recherche en Imagerie LRI-EA4062, Université Paris Descartes - Paris 5 ( UPD5 ), IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service Hospitalier Frédéric Joliot ( SHFJ ), National Institutes of Health [Bethesda] ( NIH ), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, National Institutes of Health [Bethesda] (NIH), Méthodes d'imagerie des échanges transcapillaires (LRI), IFR94-Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Paris 5 (UPD5), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Le Bihan, Denis

Subjects
MESH : Feasibility Studies, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain Mapping, MESH : Male, MESH : Dominance, Cerebral, MESH: Magnetic Resonance Imaging, MESH: Brain, MESH : Child, MESH : Verbal Behavior, MESH: Child, MESH : Adolescent, MESH : Magnetic Resonance Imaging, MESH : Female, MESH: Brain Mapping, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Adolescent, MESH: Verbal Behavior, MESH: Humans, MESH : Humans, MESH: Dominance, Cerebral, MESH: Male, MESH: Epilepsies, Partial, MESH : Epilepsies, Partial, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain, MESH: Feasibility Studies, MESH: Female
Abstract

International audience; BACKGROUND: Assessment of language organization is crucial in patients considered for epilepsy surgery. In children, the current techniques, intra-carotid amobarbital test (IAT) for language dominance, and cortical electrostimulation mapping (ESM), are invasive and risky. Functional magnetic resonance imaging (fMRI) is an alternative method for noninvasive functional mapping, through the detection of the hemodynamic changes associated with neuronal activation. We used fMRI, to assess language dominance in children with partial epilepsy. METHODS: Eleven right handed children and adolescents performed a word generation task during fMRI acquisition focused on the frontal lobes. Areas where the signal time course correlated with the test paradigm (r = 0.7) were considered activated. Extent and magnitude of signal changes were used to calculate asymmetry indices. Seven patients had IAT, ESM, or surgery outcome available for comparison. RESULTS: fMRI language dominance always agreed with IAT (6 cases) and ESM (1 case), showing left dominance in six and bilateral language in one. fMRI demonstrated left dominance in three additional children, and right dominance in one with early onset of left temporal epilepsy. Four children whose initial studies were equivocal due to noncompliance or motion artifacts were restudied successfully. CONCLUSIONS: fMRI can be used to assess language lateralization noninvasively in children. It has the potential to replace current functional mapping techniques in patients, and to provide important data on brain development.

Published
1997

40. IC-P3-218: Long-term effects of donepezil versus placebo on regional brain metabolism in minimally impaired subjects

Author

Silverman, Daniel H.S., primary, Siddarth, Prabha, additional, Geist, Cheri L., additional, Lau, Vicky, additional, Ercoli, Linda M., additional, Miller, Karen, additional, Phelps, Michael E., additional, Huang, S.C., additional, Barrio, Jorge, additional, Bookheimer, S., additional, Kaplan, A., additional, Dorsey, D., additional, Kim, Jeanne, additional, and Small, Gary W., additional

Published
2008
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