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1. Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Author

Lappin, MR, Blondeau, J, Boothe, D, Breitschwerdt, EB, Guardabassi, L, Lloyd, DH, Papich, MG, Rankin, SC, Sykes, JE, Turnidge, J, and Weese, JS

Subjects
Emerging Infectious Diseases, Lung, Infectious Diseases, Infection, Good Health and Well Being, Animals, Anti-Bacterial Agents, Bacterial Infections, Cat Diseases, Cats, Dog Diseases, Dogs, Respiratory Tract Diseases, Bronchitis, Pneumonia, Pyothorax, Rhinitis, Veterinary Sciences
Abstract

Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, the International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices for use in the management of bacterial respiratory diseases in dogs and cats.

Published
2017

20. Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats:Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Author

Lappin, M. R., Blondeau, J., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Lloyd, D. H., Papich, M. G., Rankin, S. C., Sykes, J. E., Turnidge, J., Weese, J. S., Lappin, M. R., Blondeau, J., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Lloyd, D. H., Papich, M. G., Rankin, S. C., Sykes, J. E., Turnidge, J., and Weese, J. S.

Abstract

Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, the International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices for use in the management of bacterial respiratory diseases in dogs and cats.

Published
2017

25. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases

Author

Wees, J S, Blondeau, J M, Boothe, D, Breitschwerdt, E B, Guardabassi, L, Hiilier, A, Lloyd, D H, Papich, M G, Rankin, S C, Turnidge, J D, Sykes, J E, Adelaide, Auburn, California, Copenhagen, Guelph, Canada, North Carolina State University, Ohio State University, Pennsylvania School of Veterinary Medicine, Saskatchewan, and Women'S & Children's Hospital, Australia

Abstract

Urinary tract disease is a common reason for use (and likely misuse, improper use, and overuse) of antimicrobials in dogs and cats. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, guidelines for diagnosis and management of urinary tract infections were created by a Working Group of the International Society for Companion Animal Infectious Diseases. While objective data are currently limited, these guidelines provide information to assist in the diagnosis and management of upper and lower urinary tract infections in dogs and cats.

Published
2011

27. Pharmacokinetics of Single Oral Dose Extended‐Release Levetiracetam in Healthy Cats.

Author

Barnard, L., Barnes Heller, H., and Boothe, D. M.

Subjects
ANTICONVULSANTS, TREATMENT of cat diseases, PHARMACOKINETICS, DRUG efficacy, MEDICATION safety, SPASM treatment
Abstract

Background: Repeated PO dosing of anti‐epileptic drugs may contribute to poor compliance in treated cats. Intermediate‐release levetiracetam has been used safely in cats, but must be given q8h to maintain serum concentrations in the therapeutic interval for humans (5–45 μg/mL). Approved extended‐release levetiracetam (XRL) for human use may require less frequent dosing, but the large dosing unit has limited its use in cats. Hypotheses: In healthy cats, serum levetiracetam concentration will remain above 5 μg/mL for at least 24 hours after administration of a single dose of XRL PO and will be well tolerated. Animals: 7 healthy cats. Methods: Extended‐release levetiracetam (500 mg) was administered PO. Blood was collected and neurologic examination findings recorded at scheduled times over 30 hours. Serum levetiracetam concentration was quantitated by an immunoassay validated in cats. Data were subjected to noncompartmental analysis. Descriptive statistics were reported. Results: The median dosage of 86.2 mg/kg, (range, 80–94.3) achieved a mean maximum concentration (Cmax) of 89.8 ± 25.8 μg/mL at 4.9 ±1.57 hours. Serum levetiracetam was >5 μg/mL in all cats by 90 minutes. Mean concentrations were 43.7 ± 18.4 and 4.9 ± 3.4 μg/mL at 12 and 24 hours, respectively. The half‐life was 4.1 ± 1.0 hours. The drug was well tolerated. Conclusions and Clinical Importance: A single 500 mg PO dose of XRL safely maintained serum levetiracetam concentration ≥5 μg/mL in healthy cats for at least 21 hours. Clinical efficacy studies in epileptic cats receiving XRL are indicated; however, monitoring should be implemented for individual cats. [ABSTRACT FROM AUTHOR]

Published
2018
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35. The Dosimetric Advantage of Stereotactic Hypofractionation Over Conventional Radiation for Postprostatectomy Patients: NTCP Modeling of Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) Treatment Plans

Author

Boothe, D., primary, Chang, J., additional, Desai, P., additional, Nagar, H., additional, Zhou, L., additional, Smith, M., additional, Nori, D., additional, Chao, K., additional, Wernicke, A., additional, and Parashar, B., additional

Published
2013
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45. Profile of a Malignant Brain Tumour in Jamaica: An Eight-year Review, 2005 to 2012.

Author

Johnson, P, Jaggon, JR, Campbell, J, Bruce, C, Ferron-Boothe, D, James, K, Crandon, I, and Eldemire-Shearer, D

Abstract

Copyright of West Indian Medical Journal is the property of West Indian Medical Journal (WIMJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015
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