16 results on '"Borba, Mayla Gabriela Silva"'
Search Results
2. Low handgrip strength is associated with worse functional outcomes in long-Covid
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AMARAL, Camila Miriam Suemi Sato Barros do Amaral, primary, GOULART, Cássia da Luz Goulart, additional, SILVA, Bernardo Maia da Silva, additional, VALENTE, Jefferson Valente, additional, REZENDE, Anna Gabriela Rezende, additional, FERNANDES, Eduardo Fernandes, additional, CUBAS-VEGA, Nadia Cubas-Vega, additional, BORBA, Mayla Gabriela Silva Borba, additional, SAMPAIO, Vanderson Sampaio, additional, MONTEIRO, Wuelton Monteiro, additional, MELO, Gisely Cardoso de Melo, additional, LACERDA, Marcus Lacerda, additional, ARÊAS, Guilherme Peixoto Tinoco Arêas, additional, and Almeida-Val, Fernando Almeida-Val, additional
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- 2023
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3. Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone
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Mwangi, Victor Irungu, primary, Netto, Rebeca Linhares Abreu, additional, de Morais, Carlos Eduardo Padron, additional, Silva, Arineia Soares, additional, Silva, Bernardo Maia, additional, Lima, Amanda Barros, additional, Neves, Juliana Costa Ferreira, additional, Borba, Mayla Gabriela Silva, additional, Val, Fernando Fonseca de Almeida e, additional, de Almeida, Anne Cristine Gomes, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson de Souza, additional, Gardinassi, Luiz Gustavo, additional, de Lacerda, Marcus Vinicius Guimarães, additional, Monteiro, Wuelton Marcelo, additional, and de Melo, Gisely Cardoso, additional
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- 2023
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4. Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With Coronavirus Disease 2019 (COVID-19; Metcovid): A Randomized, Double-blind, Phase IIb, Placebo-controlled Trial
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Jeronimo, Christiane Maria Prado, Farias, Maria Eduarda Leão, Val, Fernando Fonseca Almeida, Sampaio, Vanderson Souza, Alexandre, Marcia Almeida Araújo, Melo, Gisely Cardoso, Safe, Izabella Picinin, Borba, Mayla Gabriela Silva, Netto, Rebeca Linhares Abreu, Maciel, Alex Bezerra Silva, Neto, João Ricardo Silva, Oliveira, Lucas Barbosa, Figueiredo, Erick Frota Gomes, Oliveira Dinelly, Kelry Mazurega, de Almeida Rodrigues, Maria Gabriela, Brito, Marcelo, Mourão, Maria Paula Gomes, Pivoto João, Guilherme Augusto, Hajjar, Ludhmila Abrahão, Bassat, Quique, Romero, Gustavo Adolfo Sierra, Naveca, Felipe Gomes, Vasconcelos, Heline Lira, de Araújo Tavares, Michel, Brito-Sousa, José Diego, Costa, Fabio Trindade Maranhão, Nogueira, Maurício Lacerda, Baía-da-Silva, Djane Clarys, Xavier, Mariana Simão, Monteiro, Wuelton Marcelo, Lacerda, Marcus Vinícius Guimarães, de Lemos Vasconcelos, Adria, Praia Marins, Adriana Ferreira, de Oliveira Trindade, Alexandre, Mendes Záu, Aline Sales, de Oliveira, Amanda Carvalho, Azevedo Furtado, Ana Carolina, Coelho Rocha, Ana Paula, da Silva Souza, Anderson, de Souza Dias, Andiana, Belém, Aníbal, dos Santos, Anna Gabriela Rezende, da Silva Sousa, Antonny Michael, da Silva, Beatriz França, Franco, Beatriz Leitão, da Silva, Bernardo Maia, da Costa, Bleno Leonam Gonçalves, Sato Barros do Amaral, Camila Miriam Suemi, Judice, Carla C, de Morais, Carlos Eduardo Padron, Camilo, Cecília Cunha, Sena da Silva, Danielle Severino, Gomes Duarte, Debora Camila, da Silva, Ejandre Garcia Negreiros, da Silva Lemos, Elias, de Fátima Ponte Frota, Elisângela, do Nascimento, Elizandra Freitas, de Almeida, Elson Silva, Marques, Elyana Almeida, de Almeida, Emanuel Medeiros Marinho, da Silva, Emanuelle Lira, dos Santos, Ester Galvão, da Silva Oliveira, Ezequiel, Martins Shimizu, Fábio Manabu, de Souza, Fabíola Ramalho Ferreira, da Silva do Vale, Felipe, dos Santos de Almeida Lima, Fernanda, da Fonseca, Fernando Hugo Jesus, Fontenelle, Flávia Alencar, de Azevedo Furtado, Francielen, Da Silva Pereira, Gabrielle, Bezerra, Geísa Aleixo, Maciel Salazar, Guilherme Kemeron, da Silva Pereira, Handerson, de Melo, Hilda Ferreira, Oliveira, Ingrid Nascimento, Pereira Filho, Ivanildo Vieira, Gomes, Jacimara Vasques, e Silva Rosa, Jaily, Lemos, Jonas Mota, Brutus, Josué Nélio, Pessoa, Karina Pinheiro, Costa Rodrigues, Laleyska Deucylane, Barros Cirino, Larissa Esthefani, Mourão Filho, Lauro Fragata, Moura, Leandro, Barbosa, Lisiane Rísia Pinto, de Souza, Lorenna Pereira, de Lima Ferreira, Luiz Carlos, dos Santos, Marcela Menezes, da Silva, Marcus Vinicius Ramos, Rodrigues, Mauro Pereira, de Menezes, Mayara Tavares, dos Santos Mota, Micaela Maciel, Freire, Monique, Corrêa, Nadya Fonseca, Rocha, Nagila Morais, Bittencourt, Najara, de Melo Silva, Natália Guedes, de Oliveira Saraiva, Priscilla, de Sousa Monteiro, Quézia, dos Santos, Rafael Theodoro, Freire, Raíssa Soares, de Araújo Pinto, Rebecca Augusta, Ferreira, Reinan Brotas, de Lima, Rodrigo Saboia, de Melo, Rosângela Francisca Tanantas, Saenz, Sabrina Teixeira, Alvarez Fernandes, Salete Sara, Vítor-Silva, Sheila, de Oliveira, Tânia Maria Rodrigues, Tavella, Tatyana A, Câmara, Thais Tavares, Santos, Thalie Cavalcante, Pinto, Thiago Serrão, dos Santos, Tilza Waleska Rocha, do Nascimento, Valdinete Alves, Sousa Barbosa, Wanessa Pessoa, de Melo, Wellinthon Ferreira, and Salgado Sobrinho, Wlademir Braga
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Microbiology (medical) ,medicine.medical_specialty ,education.field_of_study ,medicine.drug_class ,business.industry ,Population ,Placebo-controlled study ,Subgroup analysis ,030204 cardiovascular system & hematology ,Placebo ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Methylprednisolone ,Internal medicine ,Epidemiology ,medicine ,Corticosteroid ,030212 general & internal medicine ,education ,business ,medicine.drug - Abstract
BackgroundSteroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to evaluate the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19.MethodsA parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed with hospitalized patients aged ≥18 years with clinical, epidemiological, and/or radiological suspected COVID-19 at a tertiary care facility in Manaus, Brazil. Patients were randomly allocated (1:1 ratio) to receive either intravenous MP (0.5 mg/kg) or placebo (saline solution) twice daily for 5 days. A modified intention-to-treat (mITT) analysis was conducted. The primary outcome was 28-day mortality.ResultsFrom 18 April to 16 June 2020, 647 patients were screened, 416 were randomized, and 393 were analyzed as mITT, with 194 individuals assigned to MP and 199 to placebo. SARS-CoV-2 infection was confirmed by reverse transcriptase polymerase chain reaction in 81.3%. The mortality rates at Day 28 were not different between groups. A subgroup analysis showed that patients over 60 years old in the MP group had a lower mortality rate at Day 28. Patients in the MP arm tended to need more insulin therapy, and no difference was seen in virus clearance in respiratory secretion until Day 7.ConclusionsThe findings of this study suggest that a short course of MP in hospitalized patients with COVID-19 did not reduce mortality in the overall population.Clinical Trials RegistrationNCT04343729.
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- 2020
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5. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19
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Jimenez, Leandro, primary, Campos Codo, Ana, additional, Sampaio, Vanderson de Souza, additional, Oliveira, Antonio E. R., additional, Ferreira, Lucas Kaoru Kobo, additional, Davanzo, Gustavo Gastão, additional, Brito Monteiro, Lauar de, additional, Victor Virgilio-da-Silva, João, additional, Borba, Mayla Gabriela Silva, additional, Fabiano de Souza, Gabriela, additional, Zini, Nathalia, additional, Andrade Gandolfi, Flora de, additional, Muraro, Stéfanie Primon, additional, Luiz Proença-Modena, José, additional, Val, Fernando Almeida, additional, Cardoso Melo, Gisely, additional, Monteiro, Wuelton Marcelo, additional, Nogueira, Maurício Lacerda, additional, Lacerda, Marcus Vinícius Guimarães, additional, Moraes-Vieira, Pedro M., additional, and Nakaya, Helder I., additional
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- 2021
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6. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
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Borba, Mayla Gabriela Silva, Val, Fernando Fonseca Almeida, Sampaio, Vanderson Souza, Alexandre, Marcia Almeida Araújo, Melo, Gisely Cardoso, Brito, Marcelo, Mourão, Maria Paula Gomes, Brito-Sousa, José Diego, Baía-da-Silva, Djane, Guerra, Marcus Vinitius Farias, Hajjar, Ludhmila Abrahão, Pinto, Rosemary Costa, Balieiro, Antonio Alcirley Silva, Pacheco, Antônio Guilherme Fonseca, Santos Jr, James Dean Oliveira, Naveca, Felipe Gomes, Xavier, Mariana Simão, Siqueira, André Machado, Schwarzbold, Alexandre, Croda, Júlio, Nogueira, Maurício Lacerda, Romero, Gustavo Adolfo Sierra, Bassat, Quique, Fontes, Cor Jesus, Albuquerque, Bernardino Cláudio, Daniel-Ribeiro, Cláudio-Tadeu, Monteiro, Wuelton Marcelo, and Lacerda, Marcus Vinícius Guimarães
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General Medicine - Published
- 2020
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7. Reply to Nguyen and Frost
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Jeronimo, Christiane Maria Prado, primary, Brito-Sousa, José Diego, additional, Borba, Mayla Gabriela Silva, additional, Baía-da-Silva, Djane Clarys, additional, Val, Fernando Fonseca Almeida, additional, Monteiro, Wuelton Marcelo, additional, Melo, Gisely Cardoso, additional, Sampaio, Vanderson Souza, additional, Alexandre, Marcia Almeida Araújo, additional, Xavier, Mariana, additional, Bassat, Quique, additional, Romero, Gustavo Adolfo Sierra, additional, Hajjar, Ludhmila Abrahão, additional, and Lacerda, Marcus Vinícius Guimarães, additional
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- 2020
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8. Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study
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Freire Santana, Monique, primary, Borba, Mayla Gabriela Silva, additional, Baía-da-Silva, Djane Clarys, additional, Val, Fernando, additional, Alexandre, Márcia Almeida Araújo, additional, Brito-Sousa, Jose Diego, additional, Melo, Gisely Cardoso, additional, Queiroga, Marcos Vinícius Oliveira, additional, Leão Farias, Maria Eduarda, additional, Camilo, Cecília Cunha, additional, Naveca, Felipe Gomes, additional, Xavier, Mariana Simão, additional, Monteiro, Wuelton Marcelo, additional, Augusto Pivoto João, Guilherme, additional, Hajjar, Ludhmila Abrahão, additional, Ordi, Jaume, additional, Lacerda, Marcus Vinícius Guimarães, additional, and Ferreira, Luiz Carlos Lima, additional
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- 2020
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9. Reply to Kow and Hasan
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Jerônimo, Christiane Maria Prado, primary, Val, Fernando Fonseca Almeida, additional, Borba, Mayla Gabriela Silva, additional, Sampaio, Vanderson Souza, additional, Brito-Sousa, Jose Diego, additional, Monteiro, Wuelton Marcelo, additional, Hajjar, Ludhmila Abrahão, additional, and Lacerda, Marcus Vinícius Guimarães, additional
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- 2020
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10. The influence of pH on SARS-CoV-2 infection and COVID-19 severity
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Jimenez, Leandro, primary, Codo, Ana Campos, additional, de Souza Sampaio, Vanderson, additional, Oliveira, Antonio E.R., additional, Ferreira, Lucas Kaoru Kobo, additional, Davanzo, Gustavo Gastão, additional, de Brito Monteiro, Lauar, additional, Virgilio-da-Silva, João Victor, additional, Borba, Mayla Gabriela Silva, additional, de Souza, Gabriela Fabiano, additional, Zini, Nathalia, additional, de Andrade Gandolfi, Flora, additional, Murano, Stéfanie Primon, additional, Proença-Modena, José Luiz, additional, Val, Fernando Almeida, additional, Melo, Gisely Cardoso, additional, Monteiro, Wuelton Marcelo, additional, Nogueira, Maurício Lacerda, additional, Lacerda, Marcus Vinícius Guimarães, additional, Moraes-Vieira, Pedro M., additional, and Nakaya, Helder I, additional
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- 2020
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11. Guillain–Barré Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient
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Frank, Carlos Henrique Michiles, primary, Almeida, Taynná Vernalha Rocha, additional, Marques, Elyana Almeida, additional, de Sousa Monteiro, Quezia, additional, Feitoza, Pablo Vinícius Silveira, additional, Borba, Mayla Gabriela Silva, additional, Vasconcelos, Heline Lira, additional, de Souza Bastos, Michele, additional, and Lacerda, Marcus Vinicius Guimarães, additional
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- 2020
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12. Guillain-Barré Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient.
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Frank, Carlos Henrique Michiles, Almeida, Taynná Vernalha Rocha, Marques, Elyana Almeida, Monteiro, Quezia de Sousa, Feitoza, Pablo Vinícius Silveira, Borba, Mayla Gabriela Silva, Vasconcelos, Heline Lira, Bastos, Michele de Souza, Lacerda, Marcus Vinicius Guimarães, de Sousa Monteiro, Quezia, and de Souza Bastos, Michele
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SARS-CoV-2 ,GUILLAIN-Barre syndrome ,NEUROLOGIC manifestations of general diseases ,CEREBROSPINAL fluid ,COVID-19 ,CEREBROSPINAL fluid examination ,RESEARCH funding - Abstract
We report the case of a 15-year-old male patient presenting frontal headaches with retro-orbital pain accompanied by fever evolving to weakness and pain of the lower limbs, which ascended to upper limbs. A COVID-19 rapid test (IgG and IgM) and nasopharyngeal swab polymerase chain reaction (PCR) was positive for SARS-CoV-2. The blood tests, cerebral spinal fluid (CSF) analysis and CSF aerobic culture revealed no abnormalities. PCR testing of the CSF was negative for the most prevalent etiologies as well as for SARS-CoV-2. Electroneurography study was compatible with the acute motor axonal neuropathy variant of Guillain-Barré syndrome. No cases involving young patients have been presented to date. Therefore, this is the first reported pediatric case of SARS-CoV-2 infection associated with GBS. Evidence reveals that SARS-CoV-2 infection is not limited to the respiratory tract. Neurotropism could explain this important neurologic manifestation of COVID-19 in children. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With Coronavirus Disease 2019 (COVID-19; Metcovid): A Randomized, Double-blind, Phase IIb, Placebo-controlled Trial.
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Jeronimo, Christiane Maria Prado, Farias, Maria Eduarda Leão, Val, Fernando Fonseca Almeida, Sampaio, Vanderson Souza, Alexandre, Marcia Almeida Araújo, Melo, Gisely Cardoso, Safe, Izabella Picinin, Borba, Mayla Gabriela Silva, Netto, Rebeca Linhares Abreu, Maciel, Alex Bezerra Silva, Neto, João Ricardo Silva, Oliveira, Lucas Barbosa, Figueiredo, Erick Frota Gomes, Dinelly, Kelry Mazurega Oliveira, Rodrigues, Maria Gabriela de Almeida, Brito, Marcelo, Mourão, Maria Paula Gomes, João, Guilherme Augusto Pivoto, Hajjar, Ludhmila Abrahão, and Bassat, Quique
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METHYLPREDNISOLONE ,DRUG efficacy ,REVERSE transcriptase polymerase chain reaction ,COVID-19 ,INFLAMMATION ,HEALTH outcome assessment ,RANDOMIZED controlled trials ,BLIND experiment ,STATISTICAL sampling ,POLYMERASE chain reaction ,EVALUATION - Abstract
Background Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to evaluate the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. Methods A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed with hospitalized patients aged ≥18 years with clinical, epidemiological, and/or radiological suspected COVID-19 at a tertiary care facility in Manaus, Brazil. Patients were randomly allocated (1:1 ratio) to receive either intravenous MP (0.5 mg/kg) or placebo (saline solution) twice daily for 5 days. A modified intention-to-treat (mITT) analysis was conducted. The primary outcome was 28-day mortality. Results From 18 April to 16 June 2020, 647 patients were screened, 416 were randomized, and 393 were analyzed as mITT, with 194 individuals assigned to MP and 199 to placebo. SARS-CoV-2 infection was confirmed by reverse transcriptase polymerase chain reaction in 81.3%. The mortality rates at Day 28 were not different between groups. A subgroup analysis showed that patients over 60 years old in the MP group had a lower mortality rate at Day 28. Patients in the MP arm tended to need more insulin therapy, and no difference was seen in virus clearance in respiratory secretion until Day 7. Conclusions The findings of this study suggest that a short course of MP in hospitalized patients with COVID-19 did not reduce mortality in the overall population. Clinical Trials Registration NCT04343729. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Reply to Nguyen and Frost.
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Jeronimo, Christiane Maria Prado, Brito-Sousa, José Diego, Borba, Mayla Gabriela Silva, Baía-da-Silva, Djane Clarys, Val, Fernando Fonseca Almeida, Monteiro, Wuelton Marcelo, Melo, Gisely Cardoso, Sampaio, Vanderson Souza, Alexandre, Marcia Almeida Araújo, Xavier, Mariana, Bassat, Quique, Romero, Gustavo Adolfo Sierra, Hajjar, Ludhmila Abrahão, and Lacerda, Marcus Vinícius Guimarães
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COVID-19 ,STEROIDS ,HOSPITAL mortality ,RISK assessment - Published
- 2021
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15. Invasive meningococcal disease with pericarditis and pneumonia: A rare presentation in childhood
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Borba, Mayla Gabriela Silva, primary, Oliveira, Michele Cristina, additional, João, Guilherme Augusto Pivoto, additional, Fernandes, Marcos, additional, Silva, Fernanda Matias, additional, Fragoso, Silvio, additional, Silva, Ellem Christina, additional, and Cordeiro-Santos, Marcelo, additional
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- 2016
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16. Reply to Kow and Hasan.
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Jerônimo, Christiane Maria Prado, Val, Fernando Fonseca Almeida, Borba, Mayla Gabriela Silva, Sampaio, Vanderson Souza, Brito-Sousa, Jose Diego, Monteiro, Wuelton Marcelo, Hajjar, Ludhmila Abrahão, and Lacerda, Marcus Vinícius Guimarães
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METHYLPREDNISOLONE ,DRUG efficacy ,COVID-19 ,HYPERGLYCEMIA ,STEROIDS - Abstract
The article explores clinical observations about our randomized METCOVID clinical trial on the efficacy of methylprednisolone (MP) in the adjuvant treatment of coronavirus disease 2019 (COVID-19). As the benefit of MP for 5 days was estimated to be 50%, it is likely that the overall final analysis was not powered to estimate such a difference.
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- 2021
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