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15 results on '"Borgatti, Eva Caterina"'

3. CMV-RNAemia as new marker of active viral replication in transplant recipients

Author

Piccirilli, Giulia, primary, Lanna, Federica, additional, Gabrielli, Liliana, additional, Motta, Vincenzo, additional, Franceschiello, Martina, additional, Cantiani, Alessia, additional, Pavoni, Matteo, additional, Leone, Marta, additional, Borgatti, Eva Caterina, additional, Gibertoni, Dino, additional, Pascale, Renato, additional, Giannella, Maddalena, additional, Bonifazi, Francesca, additional, and Lazzarotto, Tiziana, additional

Published
2024
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5. Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature

Author

Piccirilli, Giulia, primary, Rocca, Alessandro, additional, Borgatti, Eva Caterina, additional, Gabrielli, Liliana, additional, Zama, Daniele, additional, Pierantoni, Luca, additional, Leone, Marta, additional, Totaro, Camilla, additional, Pavoni, Matteo, additional, Lazzarotto, Tiziana, additional, and Lanari, Marcello, additional

Published
2023
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8. Fetal Brain Damage in Human Fetuses with Congenital Cytomegalovirus Infection: Histological Features and Viral Tropism

Author

Piccirilli, Giulia, primary, Gabrielli, Liliana, additional, Bonasoni, Maria Paola, additional, Chiereghin, Angela, additional, Turello, Gabriele, additional, Borgatti, Eva Caterina, additional, Simonazzi, Giuliana, additional, Felici, Silvia, additional, Leone, Marta, additional, Salfi, Nunzio Cosimo Mario, additional, Santini, Donatella, additional, and Lazzarotto, Tiziana, additional

Published
2022
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9. Universal Newborn Screening for Congenital Cytomegalovirus Infection – From Infant to Maternal Infection: A Prospective Multicenter Study

Author

Chiereghin, Angela, primary, Pavia, Claudia, additional, Turello, Gabriele, additional, Borgatti, Eva Caterina, additional, Baiesi Pillastrini, Federico, additional, Gabrielli, Liliana, additional, Gibertoni, Dino, additional, Marsico, Concetta, additional, De Paschale, Massimo, additional, Manco, Maria Teresa, additional, Ruscitto, Antonia, additional, Pogliani, Laura, additional, Bellini, Marta, additional, Porta, Alessandro, additional, Parola, Luciana, additional, Scarasciulli, Maria Luisa, additional, Calvario, Agata, additional, Capozza, Manuela, additional, Capretti, Maria Grazia, additional, Laforgia, Nicola, additional, Clerici, Pierangelo, additional, and Lazzarotto, Tiziana, additional

Published
2022
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10. FETAL BRAIN DAMAGE IN HUMAN FETUSES WITH CONGENITAL CYTOMEGALOVIRUS INFECTION: HISTOLOGICAL FEATURES AND VIRAL TROPISM

Author

Liliana Gabrielli, Piccirilli Giulia, Gabrielli Liliana, Bonasoni Maria Paola, Chiereghin Angela, Turello Gabriele, Borgatti Eva Caterina, Simonazzi Giuliana, Felici Silvia, Leone Marta, Salfi Nunzio Cosimo Mario, Santini Donatella, and Lazzarotto Tiziana

Subjects
nervous system, viruses
Abstract

Human cytomegalovirus (HCMV) causes congenital neurological lifelong disabilities. To date, the neuropathogenesis of brain injury related to congenital HCMV (cCMV) infection is poorly understood. This study evaluates the characteristics and pathogenetic mechanisms of encephalic damage in cCMV infection. Ten HCMV-infected human fetuses at 21 weeks of gestation were examined. Specifically, tissues from different brain areas were analyzed by: i) immunohistochemistry (IHC) to detect HCMV-infected cell distribution, ii) hematoxylin-eosin staining to evaluate histological damage and iii) real-time PCR to quantify tissue viral load (HCMV-DNA). The differentiation stage of HCMV-infected neural/neuronal cells was assessed by double IHC to detect simultaneously HCMV-antigens and neural/neuronal markers: nestin (expressed in early differentiation stage), doublecortin (DCX, identifying neural cells with determined lineage) and neuronal nuclei (NeuN, identifying mature neurons). HCMV-positive cells and viral DNA were found in the brain of 8/10 (80%) fetuses. For these cases, brain damage was classified as mild (n=4, 50%), moderate (n=3, 37.5%) and severe (n=1, 12.5%) based on presence and frequency of pathological findings (necrosis, microglial nodules, microglial activation, astrocytosis and vascular changes). The highest median HCMV-DNA level was found in the hippocampus (212 copies/5ng of humanDNA [hDNA], range: 10-7,505) as well as the highest mean HCMV-infected cell value (2.9 cells, range: 0-23), followed by that detected in subventricular zone (1.8 cells, range: 0-19). This suggested a preferential viral tropism for neural stem/progenitor cells (NSPCs), residing in these regions, confirmed by the expression of DCX and nestin in 94% and 63.3% of HCMV-positive cells, respectively. NeuN was not found among HCMV-positive cells and was nearly absent in the brain with severe damage, suggesting HCMV does not infect mature neurons and NSPCs do not differentiate into neurons. This could lead to known structural and functional brain defects from cCMV infection.

Published
2022

12. Off-Label Use of Letermovir as Preemptive Anti-Cytomegalovirus Therapy in a Pediatric Allogeneic Peripheral Blood Stem Cell Transplant

Author

Chiereghin,Angela, Belotti,Tamara, Borgatti,Eva Caterina, Fraccascia,Nicola, Piccirilli,Giulia, Fois,Maura, Borghi,Michele, Turello,Gabriele, Gabrielli,Liliana, Masetti,Riccardo, Prete,Arcangelo, Fanti,Stefano, Lazzarotto,Tiziana, Chiereghin,Angela, Belotti,Tamara, Borgatti,Eva Caterina, Fraccascia,Nicola, Piccirilli,Giulia, Fois,Maura, Borghi,Michele, Turello,Gabriele, Gabrielli,Liliana, Masetti,Riccardo, Prete,Arcangelo, Fanti,Stefano, and Lazzarotto,Tiziana

Abstract

Angela Chiereghin,1,2 Tamara Belotti,3 Eva Caterina Borgatti,4 Nicola Fraccascia,5 Giulia Piccirilli,6 Maura Fois,3 Michele Borghi,4 Gabriele Turello,4 Liliana Gabrielli,6 Riccardo Masetti,3 Arcangelo Prete,3 Stefano Fanti,5 Tiziana Lazzarotto4 1Section of Microbiology, Department of Specialized, Experimental, and Diagnostic Medicine, University of Bologna, Bologna, Italy; 2Department of Public Health, Local Health Authority of Bologna, Bologna, Italy; 3Pediatric Oncology and Haematology Unit “Lalla Seragnoli”, Department of Pediatrics, IRCCS St. Orsola Polyclinic, University of Bologna, Bologna, Italy; 4Microbiology Unit, Department of Specialized, Experimental, and Diagnostic Medicine, IRCCS St. Orsola Polyclinic, University of Bologna, Bologna, Italy; 5Nuclear Medicine Unit, Department of Specialized, Experimental, and Diagnostic Medicine, IRCCS St. Orsola Polyclinic, University of Bologna, Bologna, Italy; 6Microbiology Unit, IRCCS St. Orsola Polyclinic, University of Bologna, Bologna, ItalyCorrespondence: Tiziana LazzarottoMicrobiology Unit, Department of Specialized, Experimental, and Diagnostic Medicine, IRCCS St. Orsola Polyclinic, University of Bologna, via Massarenti 9, Bologna, 40138, ItalyTel +39 0512143360Fax +39 0512143514Email tiziana.lazzarotto@unibo.itAbstract: Despite the effectiveness of the currently available antiviral drugs in treating cytomegalovirus (CMV) infection, high rates of adverse effects are associated with their use. Moreover, a problem of increasing importance is the emergence of drug-resistant CMV infection. Here, we describe the first case of off-label use of letermovir (LMV) as preemptive antiviral therapy, in a pediatric allogeneic peripheral blood stem cell transplant recipient with ganciclovir-resistant CMV infection who was intolerant to foscarnet and unable to achieve viral clearance after seven doses of cidofovir. After the administration of LMV, a gradual reduction in viral load was observed and within 6

Published
2021

13. Off-Label Use of Letermovir as Preemptive Anti-Cytomegalovirus Therapy in a Pediatric Allogeneic Peripheral Blood Stem Cell Transplant

Author

Chiereghin, Angela, primary, Belotti, Tamara, additional, Borgatti, Eva Caterina, additional, Fraccascia, Nicola, additional, Piccirilli, Giulia, additional, Fois, Maura, additional, Borghi, Michele, additional, Turello, Gabriele, additional, Gabrielli, Liliana, additional, Masetti, Riccardo, additional, Prete, Arcangelo, additional, Fanti, Stefano, additional, and Lazzarotto, Tiziana, additional

Published
2021
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15. Evaluation of an automated rapid phenotypic antimicrobial susceptibility testing (ASTar, Q-linea AB) applied directly on blood cultures bottles positive for Gram-negative pathogens.

Author

Banchini I, Borgatti EC, Foschi C, Lazzarotto T, and Ambretti S

Subjects
Humans, Reproducibility of Results, Escherichia coli drug effects, Klebsiella pneumoniae drug effects, Gram-Negative Bacteria classification, Gram-Negative Bacteria drug effects, Drug Resistance, Bacterial, Microbiological Techniques methods, Bacteremia microbiology, Anti-Bacterial Agents pharmacology
Abstract

We evaluated the performance of a new rapid phenotypic antimicrobial susceptibility test (ASTar; Q-linea AB) on Gram-negative bacilli, directly from positive blood cultures bottles. MIC values obtained by the routine reference method (Microscan, Beckman Coulter) were compared to the ones provided by the tested method (ASTar). ASTar demonstrated an overall essential agreement of 98% and a category agreement of 96.1%. The overall rate of major errors and very major errors was 2.5% and 3.3%, respectively. ASTar can represent a rapid, simple, and reliable method to speed up information about antimicrobial susceptibility of Gram-negative pathogens from positive blood culture bottles.

Published
2024

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