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3. Fluorescence in situ Hybridization (FISH) in the Microbiological Diagnostic of Deep Sternal Wound Infection (DSWI)

Author

Spindler N, Moter A, Wiessner A, Gradistanac T, Borger M, Rodloff AC, Langer S, and Kikhney J

Subjects
biofilm, fish, mediastinitis, microorganisms, dswi, Infectious and parasitic diseases, RC109-216
Abstract

Nick Spindler,1 Annette Moter,2,3 Alexandra Wiessner,2,3 Tanja Gradistanac,4 Michael Borger,5 Arne C Rodloff,6 Stefan Langer,1 Judith Kikhney2,3 1Department of Orthopedic Surgery, Traumatology and Plastic Surgery, University Hospital Leipzig, Leipzig, Germany; 2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health Institute of Microbiology, Infectious Diseases and Immunology, Biofilmcenter, Berlin, Germany; 3MoKi Analytics GmbH, Berlin, Germany; 4Department of Pathology, University Clinic Leipzig, Leipzig, Germany; 5Department of Cardiac Surgery, Leipzig Heart Center, University of Leipzig, Leipzig, Germany; 6Institute of Microbiology and Epidemiology of Infectious Diseases, University Hospital Leipzig, Leipzig, GermanyCorrespondence: Nick SpindlerDepartment of Orthopedic Surgery, Traumatology and Plastic Surgery, University Hospital Leipzig, Leipzig, GermanyTel +49-341 - 9717140Fax +49-341 - 9717139Email nick.spindler@medizin.uni-leipzig.dePurpose: Postoperative mediastinitis after cardiac surgery is still a devastating complication. Insufficient microbiological specimens obtained by superficial swabbing may only detect bacteria on the surface, but pathogens that are localized in the deep tissue may be missed. The aim of this study was to analyze deep sternal wound infection (DSWI) samples by conventional microbiological procedures and fluorescence in situ hybridization (FISH) in order to discuss a diagnostic benefit of the culture-independent methods and to map spatial organization of pathogens and microbial biofilms in the wounds.Methods: Samples from 12 patients were collected and analyzed using classic microbiological culture and FISH in combination with molecular nucleic acid amplification techniques (FISHseq). Frequency of and the time to occurrence of a DSWI was recorded, previous operative interventions, complications, as well as individual risk factors and the microbiologic results were documented.Results: Tissue samples were taken from 12 patients suffering from DSWI. Classical microbiological culture resulted in the growth of microorganisms in the specimens of five patients (42%), including bacteria and in one case Candida. FISHseq gave additional diagnostic information in five cases (41%) and confirmed culture results in seven cases (59%).Conclusion: Microbial biofilms are not always present in DSWI wounds, but microorganisms are distributed in a “patchy” pattern in the tissue. Therefore, a deep excision of the wound has to be performed to control the infection. We recommend to analyze at least two wound samples from different locations by culture and in difficult to interpret cases, additional molecular biological analysis by FISHseq.Keywords: biofilm, FISH, mediastinitis, microorganisms, DSWI

Published
2021

6. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

Author

Lyon, A. R., Lopez-Fernandez, T., Couch, L. S., Asteggiano, R., Aznar, M. C., Bergler-Klein, J., Boriani, G., Cardinale, D., Cordoba, R., Cosyns, B., Cutter, D. J., de Azambuja, E., de Boer, R. A., Dent, S. F., Farmakis, D., Gevaert, S. A., Gorog, D. A., Herrmann, J., Lenihan, D., Moslehi, J., Moura, B., Salinger, S. S., Stephens, R., Suter, T. M., Szmit, S., Tamargo, J., Thavendiranathan, P., Tocchetti, C. G., van der Meer, P., van der Pal, H. J. H., Lancellotti, P., Thuny, F., Abdelhamid, M., Aboyans, V., Aleman, B., Alexandre, J., Barac, A., Borger, M. A., Casado-Arroyo, R., Cautela, J., Celutkiene, J., Cikes, M., Cohen-Solal, A., Dhiman, K., Ederhy, S., Edvardsen, T., Fauchier, L., Fradley, M., Grapsa, J., Halvorsen, S., Heuser, M., Humbert, M., Jaarsma, T., Kahan, T., Konradi, A., Koskinas, K. C., Kotecha, D., Ky, B., Landmesser, U., Lewis, B. S., Linhart, A., Lip, G. Y. H., Lochen, M. -L., Malaczynska-Rajpold, K., Metra, M., Mindham, R., Moonen, M., Neilan, T. G., Nielsen, J. C., Petronio, A. -S., Prescott, E., Rakisheva, A., Salem, J. -E., Savarese, G., Sitges, M., Ten Berg, J., Touyz, R. M., Tycinska, A., Wilhelm, M., Zamorano, J. L., Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Group, ESC Scientific Document, Lyon, Alexander R, López-Fernández, Teresa, Couch, Liam S, Asteggiano, Riccardo, Aznar, Marianne C, Bergler-Klein, Jutta, Boriani, Giuseppe, Cardinale, Daniela, Cordoba, Raul, Cosyns, Bernard, Cutter, David J, de Azambuja, Evandro, de Boer, Rudolf A, Dent, Susan F, Farmakis, Dimitrio, Gevaert, Sofie A, Gorog, Diana A, Herrmann, Joerg, Lenihan, Daniel, Moslehi, Javid, Moura, Brenda, Salinger, Sonja S, Stephens, Richard, Suter, Thomas M, Szmit, Sebastian, Tamargo, Juan, Thavendiranathan, Paaladinesh, Tocchetti, Carlo G, van der Meer, Peter, van der Pal, Helena J H, Cardiology, Clinical sciences, and Cardio-vascular diseases

Subjects
Cardiac magnetic resonance, Cancer survivors, Vascular endothelial growth factor inhibitors (VEGFi), Myocarditi, Guideline, Anthracycline, Arrhythmias, Medical Oncology, T-CELL THERAPY, Coronary artery disease, Strain, RECURRENT VENOUS THROMBOEMBOLISM, Amyloid light-chain cardiac amyloidosis, Androgen deprivation therapy, Atrial fibrillation, Biomarkers, Cancer, Carcinoid syndrome, Cardiac tumour, Cardio-oncology, Cardiotoxicity, Chemotherapy, Echocardiography, Fluoropyrimidine, Guidelines, Haematopoietic stem cell transplantation, Heart failure, Hormone therapy, Hypertension, Immunotherapy, Ischaemic heart disease, Myocarditis, Pericardial disease, Proteasome inhibitors, Pulmonary hypertension, QTc prolongation, Radiotherapy, Risk stratification, Thrombosis, Trastuzumab, Valvular heart disease, Venous thromboembolism, Neoplasms, Proteasome inhibitor, Amyloid light-chain cardiac amyloidosi, IMMUNE CHECKPOINT INHIBITORS, Cardiotoxicity/diagnostic imaging, Heart, General Medicine, Hematology, MOLECULAR-WEIGHT HEPARIN, BRAIN NATRIURETIC PEPTIDE, oncology, Cancer survivor, Thrombosi, CORONARY-ARTERY-DISEASE, Cardiology and Cardiovascular Medicine, TYROSINE KINASE INHIBITOR, Arrhythmia, Neoplasms/diagnostic imaging, Antineoplastic Agents, Humans, Radiology, Nuclear Medicine and imaging, EARLY BREAST-CANCER, CARCINOID HEART-DISEASE, Antineoplastic Agents/therapeutic use, Biomarker, AORTIC-VALVE-REPLACEMENT, Radiation Oncology
Published
2022
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7. Screening for Proximal Aortic Aneurysm by Using Noninvasive Pulse Wave Velocity as Surrogate Marker: Are We There Yet?

Author

Haunschild, J., Dörlitz, V., Meske, E., Gregoire, S., Borger, M., and Etz, C.

Subjects
PULSE wave analysis, AORTIC aneurysms, MEDICAL screening, BIOMARKERS, AORTIC rupture, INFORMED consent (Medical law)
Abstract

This article discusses the potential use of noninvasive pulse wave velocity as a screening method for proximal aortic aneurysm. The study enrolled 185 patients with and without known proximal aortic aneurysm and/or aortic valve disease. The results showed that pulse wave velocity was significantly higher in patients without aortic aneurysm, suggesting that it could be a useful tool for determining cardiovascular risk and screening for proximal aortic aneurysm. However, further studies are needed to validate these findings and correlate them with other imaging methods. [Extracted from the article]

Published
2024
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8. Neurological Outcome in Spinal Cord Blood Flow Reduction by Cerebrospinal Fluid Pressure Increase—A Chronic Large Animal Model.

Author

Haunschild, J., Veit, S., Nauck, N., von Aspern, K., Ossmann, S., Borger, M., and Etz, C.

Subjects
SPINAL cord, CEREBROSPINAL fluid, BLOOD flow, FLUID pressure, CEREBROSPINAL fluid shunts, ANIMAL models in research
Abstract

This article discusses the neurological outcome in a chronic large animal model of spinal cord blood flow reduction caused by an increase in cerebrospinal fluid (CSF) pressure. The study used a large animal model and found that increasing CSF pressure led to a decrease in spinal cord perfusion, even in the presence of open segmental arteries. However, despite the decrease in blood flow, no neurological impairment was observed during the three-day follow-up period. The study also found that slower depressurization resulted in less pronounced hyperperfusion. Overall, the findings suggest that the spinal cord has sufficient ischemic tolerance to survive a reduction in blood flow. [Extracted from the article]

Published
2024
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11. 2023 ESC Guidelines for the management of endocarditis

Author

Delgado, V, Ajmone Marsan, N, de Waha, S, Bonaros, N, Brida, M, Burri, H, Caselli, S, Doenst, T, Ederhy, S, Erba, P, Foldager, D, Fosbøl, E, Kovac, J, Mestres, C, Miller, O, Miro, J, Pazdernik, M, Pizzi, M, Quintana, E, Rasmussen, T, Ristić, A, Rodés-Cabau, J, Sionis, A, Zühlke, L, Borger, M, Delgado, Victoria, Ajmone Marsan, Nina, de Waha, Suzanne, Bonaros, Nikolaos, Brida, Margarita, Burri, Haran, Caselli, Stefano, Doenst, Torsten, Ederhy, Stephane, Erba, Paola Anna, Foldager, Dan, Fosbøl, Emil L, Kovac, Jan, Mestres, Carlos A, Miller, Owen I, Miro, Jose M, Pazdernik, Michal, Pizzi, Maria Nazarena, Quintana, Eduard, Rasmussen, Trine Bernholdt, Ristić, Arsen D, Rodés-Cabau, Josep, Sionis, Alessandro, Zühlke, Liesl Joanna, Borger, Michael A, Delgado, V, Ajmone Marsan, N, de Waha, S, Bonaros, N, Brida, M, Burri, H, Caselli, S, Doenst, T, Ederhy, S, Erba, P, Foldager, D, Fosbøl, E, Kovac, J, Mestres, C, Miller, O, Miro, J, Pazdernik, M, Pizzi, M, Quintana, E, Rasmussen, T, Ristić, A, Rodés-Cabau, J, Sionis, A, Zühlke, L, Borger, M, Delgado, Victoria, Ajmone Marsan, Nina, de Waha, Suzanne, Bonaros, Nikolaos, Brida, Margarita, Burri, Haran, Caselli, Stefano, Doenst, Torsten, Ederhy, Stephane, Erba, Paola Anna, Foldager, Dan, Fosbøl, Emil L, Kovac, Jan, Mestres, Carlos A, Miller, Owen I, Miro, Jose M, Pazdernik, Michal, Pizzi, Maria Nazarena, Quintana, Eduard, Rasmussen, Trine Bernholdt, Ristić, Arsen D, Rodés-Cabau, Josep, Sionis, Alessandro, Zühlke, Liesl Joanna, and Borger, Michael A

Published
2023

12. Incidence and Outcomes of Emergent Intraprocedural Surgical Conversion during Transcatheter Aortic Valve Implantation: Insights from a Multicentric Germany-Wide Analysis

Author

Marin-Cuartas, M., additional, De Waha, S., additional, Naumann, S., additional, Deo, V.S., additional, Noack, T., additional, Hoyer, A., additional, Holzhey, D., additional, Leontyev, S., additional, Saeed, D., additional, Misfeld, M., additional, Ender, J., additional, Abdel-Wahab, M., additional, Desch, S., additional, Thiele, H., additional, Borger, M., additional, and Kiefer, P., additional

Published
2023
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15. Validation Study of a Survival Predictor Formula for Patients Bridged from Extracorporeal Life Support (ECLS) to Durable Mechanical Circulatory Support Systems: On behalf of Durable MCS after ECLS Study Group

Author

Saeed, D., additional, Stark, C., additional, Loforte, A., additional, Zimpfer, D., additional, Bernhardt, A., additional, Schibilsky, D., additional, Riebandt, J., additional, Jawad, K., additional, Lichtenberg, A., additional, Haneya, A., additional, Potapov, E., additional, Albert, A., additional, Otto, W., additional, Huenges, K., additional, Aubin, H., additional, Lewin, D., additional, Raweh, A., additional, Morshuis, M., additional, Jorde, U., additional, Reichenspurner, H., additional, Borger, M., additional, and Gummert, J., additional

Published
2023
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16. Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel

Author

Delling, F. N., Noseworthy, P. A., Adams, D. H., Basso, C., Borger, M., Bouatia-Naji, N., Elmariah, S., Evans, F., Gerstenfeld, E., Hung, J., Le Tourneau, T., Lewis, J., Miller, M. A., Norris, R. A., Padala, M., Perazzolo-Marra, M., Shah, D. J., Weinsaft, J. W., Enriquez-Sarano, M., and Levine, R. A.

Subjects
Mitral Valve Prolapse, cardiac magnetic resonance imaging, Cardiorespiratory Medicine and Haematology, Cardiovascular, Sudden, sudden cardiac death, Death, echocardiography, mitral regurgitation, mitral valve prolapse, Death, Sudden, Cardiac, Heart Disease, Cardiovascular System & Hematology, Clinical Research, Public Health and Health Services, Humans, 2.1 Biological and endogenous factors, Aetiology, Cardiac
Abstract

In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying those at higher risk is key. For the first time in decades, researchers have the means to rapidly advance discovery in the field of MVP thanks to state-of-the-art imaging techniques, novel omics methodologies, and the potential for large-scale collaborations using web-based platforms. The National Heart, Lung, and Blood Institute recently initiated a webinar-based workshop to identify contemporary research opportunities in the treatment of MVP. This report summarizes 3 specific areas in the treatment of MVP that were the focus of the workshop: 1) improving management of degenerative mitral regurgitation and associated left ventricular systolic dysfunction; 2) preventing sudden cardiac death in MVP; and 3)understanding the mechanisms and progression of MVP through genetic studies and small and large animal models, with the potential of developing medical therapies.

Published
2022

19. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., Zamorano J. L., Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., and Zamorano J. L.

Published
2021

22. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, Zamorano, JL, Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, and Zamorano, JL

Published
2022

26. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Back, M., Benetos, A., Biffi, A., Boavida, J. -M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., DI Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M., Jankowska, E. A., Michal, M., Sacco, S., Sattar, N., Tokgozoglu, L., Tonstad, S., Tsioufis, K. P., Van DIs, I., Van Gelder, I. C., Wanner, C., Williams, B., De Backer, G., Regitz-Zagrosek, V., Aamodt, A. H., Abdelhamid, M., Aboyans, V., Albus, C., Asteggiano, R., Borger, M. A., Brotons, C., Ielutkiene, J., Cifkova, R., Cikes, M., Cosentino, F., Dagres, N., De Backer, T., De Bacquer, D., Delgado, V., Den Ruijter, H., Dendale, P., Drexel, H., Falk, V., Fauchier, L., Ference, B. A., Ferrieres, J., Ferrini, M., Fisher, M., Fliser, D., Fras, Z., Gaita, D., Giampaoli, S., Gielen, S., Graham, I., Jennings, C., Jorgensen, T., Kautzky-Willer, A., Kavousi, M., Koenig, W., Konradi, A., Kotecha, D., Landmesser, U., Lettino, M., Lewis, B. S., Linhart, A., Lochen, M. -L., Makrilakis, K., Mancia, G., Marques-Vidal, P., Mcevoy, J. W., Mcgreavy, P., Merkely, B., Neubeck, L., Nielsen, J. C., Perk, J., Petersen, S. E., Petronio, A. S., Piepoli, M., Pogosova, N. G., Prescott, E. I. B., Ray, K. K., Reiner, Z., Richter, D. J., Ryden, L., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sudano, I., Tiberi, M., Touyz, R. M., Ungar, A., Verschuren, W. M. M., Wiklund, O., Wood, D., Zamorano, J. L., Crawford, C. A., Franco Duran, O. H., Richard Hobbs, F. D., Dis, I. V., Group, ESC Scientific Document, Clinical sciences, Cardio-vascular diseases, and Cardiology

Subjects
medicine.medical_specialty, Epidemiology, Population, air pollution, population, Guidelines, blood pressure, climate change, diabetes, healthy lifestyle, lifetime benefit, lifetime risk, lipids, nutrition, personalized, prevention, psychosocial factors, risk estimation, risk management, shared decision-making, smoking, stepwise approach, Risk Assessment, Humans, Primary Prevention, Risk Factors, Cardiovascular Diseases, Diabetes mellitus, medicine, Intensive care medicine, education, 610 Medicine & health, Risk management, education.field_of_study, business.industry, medicine.disease, Clinical Practice, Blood pressure, guidelines, Heart failure, Lifetime risk, Disease prevention, Cardiology and Cardiovascular Medicine, business, Stepwise approach, 360 Social problems & social services
Abstract

These are the clinical practice guidelines from the European Society of Cardiology on cardiovascular disease prevention in clinical practice, from 2021.

Published
2022
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27. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabes, J. A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A. J. S., Deharo, J. -C., Delgado, V., Diller, G. -P., Israel, C. W., Keren, A., Knops, R. E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Thylen, I., Tolosana, J. M., Leyva, F., Linde, C., Abdelhamid, M., Aboyans, V., Arbelo, E., Asteggiano, R., Baron-Esquivias, G., Bauersachs, J., Biffi, M., Birgersdotter-Green, U., Bongiorni, M. G., Borger, M. A., Celutkiene, J., Cikes, M., Daubert, J. -C., Drossart, I., Ellenbogen, K., Elliott, P. M., Fabritz, L., Falk, V., Fauchier, L., Fernandez-Aviles, F., Foldager, D., Gadler, F., De Vinuesa, P. G. G., Gorenek, B., Guerra, J. M., Hermann Haugaa, K., Hendriks, J., Kahan, T., Katus, H. A., Konradi, A., Koskinas, K. C., Law, H., Lewis, B. S., Linker, N. J., Lochen, M. -L., Lumens, J., Mascherbauer, J., Mullens, W., Nagy, K. V., Prescott, E., Raatikainen, P., Rakisheva, A., Reichlin, T., Ricci, R. P., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sutton, R., Suwalski, P., Svendsen, J. H., Touyz, R. M., Van Gelder, I. C., Vernooy, K., Waltenberger, J., Whinnett, Z., Witte, K. K., Qoriany, A., Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Pacemaker, Artificial, Cardiac pacing, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], cardiac resynchronization therapy, heart failure, temporary pacing, law.invention, law, atrial fibrillation, 610 Medicine & health, ComputingMilieux_MISCELLANEOUS, biology, Cardiac Pacing, Artificial, Syncope (genus), Atrial fibrillation, syncope, Cardiology, cardiovascular system, medicine.symptom, guidelines, cardiac pacing, pacemaker, conduction system pacing, pacing indications, alternate site pacing, complications, pacing in TAVI, bradycardia, Cardiology and Cardiovascular Medicine, Bradycardia, medicine.medical_specialty, Cardiac resynchronization therapy, Guidelines, Physiology (medical), Internal medicine, medicine, Humans, Task force, business.industry, Stroke Volume, 1103 Clinical Sciences, medicine.disease, biology.organism_classification, Heart Rhythm, Cardiovascular System & Hematology, Heart failure, Artificial cardiac pacemaker, business, Atrioventricular block
Abstract

These are the clinical practice guidelines of the European Society of Cardiology on cardiac pacing and cardiac resynchronization therapy, from 2021.

Published
2022
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28. Increased Incidence of Mitral Valve and Streptococcus-Related Infective Endocarditis after the 2009 ESC Prophylaxis Guideline Modifications

Author

Weber, C., additional, Luehr, M., additional, Petrov, G., additional, Misfeld, M., additional, Akhyari, P., additional, Tugtekin, S. M., additional, Diab, M., additional, Saha, S., additional, Elderia, A., additional, Lichtenberg, A., additional, Hagl, C., additional, Doenst, T., additional, Matschke, K., additional, Borger, M. A., additional, and Wahlers, T., additional

Published
2022
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34. Combined Coronary CT-angiography And TAVI-planning For Ruling-out Significant Coronary Artery Disease: Added Value Of Machine-Learning Based CT-FFR

Author

Gohmann, R., primary, Pawelka, K., additional, Seitz, P., additional, Majunke, N., additional, Desch, S., additional, Lauten, P., additional, Holzhey, D., additional, Noak, T., additional, Kiefer, P., additional, Krieghoff, C., additional, Gottschling, S., additional, Lücke, C., additional, Wilde, J., additional, Ebel, S., additional, Borger, M., additional, Thiele, H., additional, Abdel-Wahab, M., additional, and Gutberlet, M., additional

Published
2021
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35. Correction to: European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria (Journal of Cardiothoracic Surgery, (2021), 16, 1, (171), 10.1186/s13019-021-01536-5)

Author

Biancari, F., Mariscalco, G., Yusuff, H., Tsang, G., Luthra, S., Onorati, F., Francica, A., Rossetti, C., Perrotti, A., Chocron, S., Fiore, A., Folliguet, T., Pettinari, M., Dell'Aquila, A. M., Demal, T., Conradi, L., Detter, C., Pol, M., Ivak, P., Schlosser, F., Forlani, S., Chetty, G., Harky, A., Kuduvalli, M., Field, M., Vendramin, I., Livi, U., Rinaldi, M., Ferrante, L., Etz, C., Noack, T., Mastrobuoni, S., De Kerchove, L., Jormalainen, M., Laga, S., Meuris, B., Schepens, M., Dean, Z. E., Vento, A., Raivio, P., Borger, M., and Juvonen, T.

Published
2021

36. Surgical Explantation After TAVR Failure: Mid-Term Outcomes From the EXPLANT-TAVR International Registry

Author

Bapat, V. N., Zaid, S., Fukuhara, S., Saha, S., Vitanova, K., Kiefer, P., Squiers, J. J., Voisine, P., Pirelli, L., von Ballmoos, M. W., Chu, M. W. A., Rodes-Cabau, J., Dimaio, J. M., Borger, M. A., Lange, R., Hagl, C., Denti, P., Modine, T., Kaneko, T., Tang, G. H. L., Sengupta, A., Holzhey, D., Noack, T., Harrington, K. B., Mohammadi, S., Brinster, D. R., Atkins, M. D., Algadheeb, M., Bagur, R., Desai, N. D., Bhadra, O. D., Conradi, L., Shults, C., Satler, L. F., Ramlawi, B., Robinson, N. B., Wang, L., Petrossian, G. A., Andreas, M., Werner, P., Garatti, A., Vincent, F., Van Belle, E., Juthier, F., Leroux, L., Doty, J. R., Goldberg, J. B., Ahmad, H. A., Goel, K., Shah, A. S., Geirsson, A., Forrest, J. K., Grubb, K. J., Hirji, S., Shah, P. B., Bruschi, G., Gelpi, G., Belluschi, I., Ouzounian, M., Ruel, M., Al-Atassi, T., Kempfert, J., Unbehaun, A., Van Mieghem, N. M., Hokken, T. W., Ben Ali, W., Ibrahim, R., Demers, P., Pizano, A., Di Eusanio, M., Capestro, F., Estevez-Loureiro, R., Pinon, M. A., Salinger, M. H., Rovin, J., D'Onofrio, A., Tessari, C., Di Virgilio, A., Taramasso, M., Gennari, M., Colli, A., Whisenant, B. K., Nazif, T. M., Kleiman, N. S., Szerlip, M. Y., Waksman, R., George, I., Nguyen, T. C., Maisano, F., Deeb, G. M., Bavaria, J. E., Reardon, M. J., Mack, M. J., Brinkman, W. T., George, T. J., Potluri, S., Ryan, W. H., Schaffer, J. M., Smith, R. L., Szerlip, M., Nazif, T., Rahim, H., Grubb, K., Atkins, M., Goel, S., Kleiman, N., Reardon, M., Doty, J., Whisenant, B., Salinger, M., Satler, L., Schults, C., Fisher, S., Alexis, S. L., Kliger, C. A., Rutkin, B., P. -J., Yu, Petrossian, G., Robinson, N., Deeb, M., Oakley, J., Bavaria, J., Desai, N., Walsh, L., Nguyen, T., Ahmad, H., Goldberg, J., Spielvogel, D., Forrest, J., Chu, M., Cartier, R., Abois, A. -P., Boodhwani, M., Dick, A., Glover, C., Labinaz, M., Lam, B. -K., Delhaye, C., Delsaux, A., Denimal, T., Gaul, A., Koussa, M., Pamart, T., Sonnabend, S., Krane, M., Munsterer, A., Bhadra, O., Merlanti, B., Russo, C. F., Romagnoni, C., and Pinnon, M.

Subjects
TAVR explantation, TAVR failure, surgical aortic valve replacement, transcatheter aortic valve replacement
Published
2021

37. European registry of type A aortic dissection (ERTAAD):rationale, design and definition criteria

Author

Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), Juvonen, T. (Tatu), Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), and Juvonen, T. (Tatu)

Abstract

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient’s conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. Methods: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient’s comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit. Discussion: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD. Trial registration: ClinicalTrials.gov Identifier: NCT04831073.

Published
2021

40. Neurological Complications in Patients Requiring Durable VAD Systems after ECLS Support. On Behalf of ECLS- Durable MCS Study Group

Author

Saeed, D., primary, Potapov, E., additional, Loforte, A., additional, Morshuis, M., additional, Schibilsky, D., additional, Zimpfer, D., additional, Riebandt, J., additional, Pappalardo, F., additional, Attisani, M., additional, Rinaldi, M., additional, Haneya, A., additional, Ramjankhan, F., additional, Donker, D., additional, Jorde, U., additional, Stein, J., additional, Tsyganenko, D., additional, Jawad, K., additional, Wieloch, R., additional, Ayala, R., additional, Cremer, J., additional, Borger, M., additional, Lichtenberg, A., additional, and Gummert, J., additional

Published
2021
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48. (228) Optimal Patient Selection on Extra-Corporeal Life Support for Durable Mechanical Circulatory Support: Validation Study on Behalf of Durable MCS after ECLS Study Group

Author

Saeed, D., Stark, C., Loforte, A., Zimpfer, D., Bernhardt, A., Schibilsky, D., Riebandt, J., Jawad, K., Lichtenberg, A., Haneya, A., Potapov, E., Albert, A., Otto, W., Huenges, K., Aubin, H., Lewin, D., Raweh, A., Morshuis, M., Jorde, U., Reichenspurner, H., Borger, M., and Gummert, J.

Published
2023
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