Search

Your search keyword '"Borko, Tyler L."' showing total 7 results
Start Over Author "Borko, Tyler L."
7 results on '"Borko, Tyler L."'

2. SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis

Author

Baxter, Ryan M., primary, Cabrera-Martinez, Berenice, additional, Ghosh, Tusharkanti, additional, Rester, Cody, additional, Moreno, Miguel Guerrero, additional, Borko, Tyler L., additional, Selva, Sean, additional, Fleischer, Chelsie L., additional, Haakonsen, Nicola, additional, Mayher, Ariana, additional, Bowhay, Emily, additional, Evans, Courtney, additional, Miller, Todd M., additional, Huey, Leah, additional, McWilliams, Jennifer, additional, van Bokhoven, Adrie, additional, Deane, Kevin D., additional, Knight, Vijaya, additional, Jordan, Kimberly R., additional, Ghosh, Debashis, additional, Klarquist, Jared, additional, Kedl, Ross M., additional, Piquet, Amanda L., additional, and Hsieh, Elena W. Y., additional

Published
2024
Full Text
View/download PDF

3. SARS-CoV-2 mRNA vaccination induces an antigen-specific T cell response correlating with plasma interferon-gamma in B cell depleted patients

Author

Borko, Tyler L., primary, Baxter, Ryan, additional, Cabrera-Martinez, Berenice, additional, Thiruppathi, Eagappanath, additional, Sabalza, Maite, additional, Venkataraman, Iswariya, additional, Selva, Sean, additional, Rester, Cody, additional, Sillau, Stefan, additional, Pastula, Daniel M., additional, Bennett, Jeffrey L., additional, Alvarez, Enrique, additional, Gross, Robert, additional, Shah, Anna, additional, Kammeyer, Ryan, additional, Corboy, John R., additional, Kedl, Ross M., additional, Hsieh, Elena W.Y., additional, and Piquet, Amanda L., additional

Published
2023
Full Text
View/download PDF

5. An Observational Study on the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis and Other Autoimmune Neurological Disorders Treated With Anti-CD20 Therapies

Author

Borko, Tyler L., primary, Selva, Sean, additional, Baxter, Ryan, additional, Cabrera-Martinez, Berenice, additional, Rester, Cody, additional, Sillau, Stefan, additional, Pastula, Daniel M., additional, Sabalza, Maite, additional, Venkataraman, Iswariya, additional, Thiruppathi, Eagappanath, additional, Bennett, Jeffrey L., additional, Alvarez, Enrique, additional, Gross, Robert, additional, Shah, Anna, additional, Kammeyer, Ryan, additional, Vollmer, Timothy L., additional, Kedl, Ross, additional, Corboy, John R., additional, Hsieh, Elena, additional, and Piquet, Amanda L., additional

Published
2022
Full Text
View/download PDF

6. Examining the Differences in Biomarkers of Neuronal and Glial Injury Between Autoimmune Neurologic Disease Patients and Healthy Controls

Author

Borko, Tyler L., primary, Barrera, Britney, additional, Mizenko, Christopher, additional, Ledreux, Aurélie, additional, Kammeyer, Ryan, additional, Ritchie, Alanna, additional, Selva, Sean, additional, Sillau, Stefan, additional, Engebretson, Eric, additional, Seale, Rebecca, additional, Valdez, Brooke, additional, Bennett, Jeffrey L., additional, Vollmer, Timothy L., additional, Nair, Kavita, additional, and Piquet, Amanda, additional

Published
2022
Full Text
View/download PDF

7. Blood-based biomarkers of neuronal and glial injury in active major neuropsychiatric systemic lupus erythematosus.

Author

Kammeyer, Ryan, Chapman, Kimberly, Furniss, Anna, Hsieh, Elena, Fuhlbrigge, Robert, Ogbu, Ekemini A., Boackle, Susan, Zell, JoAnn, Nair, Kavita V., Borko, Tyler L., Cooper, Jennifer C., Bennett, Jeffrey L., and Piquet, Amanda L.

Subjects
*GLIAL fibrillary acidic protein, *DEMYELINATION, *KIDNEY physiology, *STROKE, *SEIZURES (Medicine), *POLYNEUROPATHIES
Abstract

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a poorly understood and heterogeneous manifestation of SLE. Common major NPSLE syndromes include strokes, seizures, myelitis, and aseptic meningitis. Easily obtainable biomarkers are needed to assist in early diagnosis and improve outcomes for NPSLE. A frequent end-result of major syndromes is neuronal or glial injury. Blood-based neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) have been utilized as markers for monitoring disease activity and/or severity in other neurodegenerative and neuroinflammatory diseases; however, they have not been evaluated in active major NPSLE.This was a case-control study. We enrolled patients aged 12-60 years with active major NPSLE, SLE without active major NPSLE, and healthy controls. Active NPSLE was defined as being <6 months from last new or worsening neuropsychiatric symptom. Demographics, clinical data, and serum or plasma biosamples were collected.Thirteen patients with active major NPSLE, 13 age/sex/kidney function matched SLE controls without active major NPSLE, and 13 age/sex matched healthy controls (mean ages 26.8, 27.3, 26.6 years) were included. 92% of each group were female. Major syndromes included stroke (5), autonomic disorder (3), demyelinating disease (2), aseptic meningitis (2), sensorimotor polyneuropathy (2), cranial neuropathy (1), seizures (1), and myelopathy (2). Mean (standard deviation) blood NfL and GFAP were 3.6 pg/ml (2.0) and 50.4 pg/ml (15.0), respectively, for the healthy controls. Compared to healthy controls, SLE without active major NPSLE had mean blood NfL and GFAP levels 1.3 pg/ml (p = .42) and 1.2 pg/ml higher (p = .53), respectively. Blood NfL was on average 17.9 pg/ml higher (95% CI: 9.2, 34.5; p < .001) and blood GFAP was on average 3.2 pg/ml higher (95% CI: 1.9, 5.5; p < .001) for cases of active major NPSLE compared to SLE without active major NPSLE. In a subset of 6 patients sampled at multiple time points, blood NfL and GFAP decreased after immunotherapy.Blood NfL and GFAP levels are elevated in persons with SLE with active major NPSLE compared to disease matched controls and may lower after immunotherapy initiation. Larger and longitudinal studies are needed to ascertain their utility in a clinical setting. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results