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974 results on '"Bornehag, Carl-Gustaf"'

12. Prenatal Exposure to a Human Relevant Mixture of Endocrine-Disrupting Chemicals Affects Mandibular Development in Mice.

Author

Rinotas, Vagelis, Stamatakis, Antonios, Stergiopoulos, Athanasios, Bornehag, Carl-Gustaf, Rüegg, Joëlle, Armaka, Marietta, and Kitraki, Efthymia

Subjects
ENDOCRINE disruptors, MANDIBLE, MAMMAL growth, ALVEOLAR process, PRENATAL exposure
Abstract

Mandible is a bony structure of neuroectodermal origin with unique characteristics that support dentition and jaw movements. In the present study, we investigated the effects of gestational exposure to a mixture of endocrine-disrupting chemicals (EDCs) on mandibular growth in mice. The mixture under study (Mixture N1) has been associated with neurodevelopmental effects in both a human cohort and animal studies. Pregnant mice were exposed throughout gestation to 0.5× (times of pregnant women's exposure levels), 10×, 100× and 500× of Mixture N1, or the vehicle, and the mandibles of the male offspring were studied in adulthood. Micro-CT analysis showed non-monotonic effects of Mixture N1 in the distances between specific mandibular landmarks and in the crown width of M1 molar, as well as changes in the mandibular bone characteristics. The alveolar bone volume was reduced, and the trabecular separation was increased in the 500× exposed mice. Bone volume in the condyle head was increased in all treated groups. Τhe Safranin-O-stained area of mature hypertrophic chondrocytes and the width of their zones were reduced in 0.5×, 10× and 100× exposed groups. This is the first indication that prenatal exposure to an epidemiologically defined EDC mixture, associated with neurodevelopmental impacts, can also affect mandibular growth in mammals. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Gender-specific play behavior in relation to autistic traits and behavioral difficulties at the age of seven in the SELMA study.

Author

Özel, Fatih, Stratmann, Marlene, Papadopoulos, Fotios C., Rüegg, Joëlle, and Bornehag, Carl-Gustaf

Subjects
GENDER nonconformity, AUTISM spectrum disorders, LOGISTIC regression analysis, GENDER dysphoria, PSYCHOLOGICAL distress, AUTISTIC children
Abstract

Background: Childhood gender nonconformity is related to psychological distress and behavioral difficulties. Similarly, there is evidence for a link between gender nonconformity, or gender dysphoria in some studies, and autism spectrum disorder and related traits. Our knowledge on those associations mostly originates from clinical populations, which might lead to overestimation. Thus, this study aimed to assess associations between gender nonconformity and behavioral difficulties in a population-based study. Methods: In the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy (SELMA) study, cross-sectional associations between gender-specific play behavior and behavioral outcomes and autistic traits were investigated among 718 children at 7-years of age. Play behavior was measured using the Preschool Activities Inventory; behavioral outcomes and autistic traits were measured with the Strengths and Difficulties Questionnaire and the Social Responsiveness Scale, respectively. Linear and logistic regression analyses were performed. Results: Higher composite play behavior scores (indicating either increased masculine or decreased feminine play behavior) were associated with increased autistic trait scores in girls (β = 0.13; 95% confidence interval [CI] = 0.00, 0.26). Furthermore, higher composite scores were shown to be associated with behavioral difficulties in both girls (β = 0.11; 95% CI = 0.04, 0.18) and boys (β = 0.10; 95% CI = 0.02, 0.19). Additionally, higher feminine scores were related with increased problems in peer relationships in boys (β = 0.04; 95% CI = 0.00, 0.07). Conclusions: This study suggests a link between gender nonconforming play behavior and autistic traits as well as behavioral difficulties among children in a non-clinical population, which calls attention to the necessity of supporting children with gender nonconformity from early ages. [ABSTRACT FROM AUTHOR]

Published
2024
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26. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Author

Vandenberg, Laura N, Ågerstrand, Marlene, Beronius, Anna, Beausoleil, Claire, Bergman, Åke, Bero, Lisa A, Bornehag, Carl-Gustaf, Boyer, C Scott, Cooper, Glinda S, Cotgreave, Ian, Gee, David, Grandjean, Philippe, Guyton, Kathryn Z, Hass, Ulla, Heindel, Jerrold J, Jobling, Susan, Kidd, Karen A, Kortenkamp, Andreas, Macleod, Malcolm R, Martin, Olwenn V, Norinder, Ulf, Scheringer, Martin, Thayer, Kristina A, Toppari, Jorma, Whaley, Paul, Woodruff, Tracey J, and Rudén, Christina

Subjects
Epidemiology, Health Sciences, Endocrine Disruptors, Estrogen, Good Health and Well Being, Animals, Environmental Exposure, Environmental Pollutants, Humans, Models, Theoretical, Risk Assessment, Toxicity Tests, Endocrine disrupting chemicals, Systematic review, Study evaluation, Strength of evidence, Weight of evidence, Adverse effect, Endocrine disrupting activity, Evidence integration, In vivo, Public Health and Health Services, Toxicology, Public health
Abstract

BackgroundThe issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.MethodsWe have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.ResultsBuilding from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.ConclusionsWhen using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.

Published
2016

28. Associations between Motor Competence, Physical Activity and Sedentary Behaviour among Early School-Aged Children in the SELMA Cohort Study

Author

Delvert, Johanna, Wadensjö, Helene V, Bornehag, Carl-Gustaf, Wikström, Sverre, Delvert, Johanna, Wadensjö, Helene V, Bornehag, Carl-Gustaf, and Wikström, Sverre

Abstract

Low motor competence (MC) has been associated with lower physical activity (PA) and long-term health risks in children. Less is known about sex-specific patterns and associations during early school age. The aim of this study was to explore how motor difficulties are associated with PA levels, screen time, and organised sports participation (OSP). Data from 479 children, seven years of age, participating in the Swedish Environmental, Longitudinal, Mother and child, Asthma, and allergy (SELMA) pregnancy cohort study were used. MC and activity-related outcomes were assessed with questionnaires answered by parents. Associations between MC and outcomes were evaluated using logistic regression models adjusted for sex, overweight, and parental education level. Sex differences were investigated with interaction analyses and in stratified models. Children with motor difficulties had the same level of PA as their peers, but more screen time and lower OSP. Compared with children with normal MC, boys with motor difficulties had lower rates of OSP, but girls did not. This indicates that the identification and compensatory support for motor difficulties for boys at an early age, as well as the development of inclusive leisure time activities, are of importance to facilitate health-promoting activities on equal terms.

Published
2024
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29. Do Wechsler intelligence scales predict academic achievement in children with ADHD or autism? : A systematic review and meta-analysis

Author

Marinopoulou, Maria, Åsberg Johnels, Jakob, Bornehag, Carl-Gustaf, Unenge Hallerbäck, Maria, Billstedt, Eva, Marinopoulou, Maria, Åsberg Johnels, Jakob, Bornehag, Carl-Gustaf, Unenge Hallerbäck, Maria, and Billstedt, Eva

Abstract

Intelligence tests predict academic achievement in typically developed children, however if this is the case also in children with attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) is not clear. This systematic review and meta-analysis examined if Wechsler intelligence scales predict academic achievement and/or grades in children, ages 6-16 years, with ADHD and/or ASD. We searched the databases PubMed, PsycINFO and Education Research Complete for studies published between 2000 and 2023. We used the Newcastle-Ottawa Scale to assess risk of bias. Narrative synthesis and meta-analysis were performed. Twelve studies (ADHD n = 1,834, ASD n = 176) were included in the review, and six samples (ADHD n = 1,112) of those were included in the meta-analyses. The results of the meta-analyses showed moderate overall weighted correlations between IQ and word reading, written language, and mathematics respectively. Similarly, the overall weighted correlations between processing speed and the aforementioned domains of academic achievement were moderate. Meta-analysis with additional Wechsler scales composite scores could not be conducted. In the narrative synthesis, Full Scale IQ was associated with academic achievement in both ADHD and ASD, and grades in ADHD. The limited number of ASD participants and the heterogeneity of the samples need to be considered when interpreting results. Generally, the results indicate that Wechsler scales are valuable in predicting academic achievement in children with ADHD or ASD. Motivation and other factors related with academic achievement need to be further explored in these groups.

Published
2024
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35. The Shift in Human Health from Infection-Related Diseases to Chronic Illnesses and the Importance of Indoor Chemical Exposure

Author

Bornehag, Carl-Gustaf, Hutzinger, Otto, Editor-in-chief, Barceló, Damià, Editor-in-chief, Kostianoy, Andrey G., Editor-in-chief, de Boer, Jacob, Advisory Editor, Garrigues, Philippe, Advisory Editor, Gu, Ji-Dong, Advisory Editor, Jones, Kevin C., Advisory Editor, Knepper, Thomas P., Advisory Editor, Newton, Alice, Advisory Editor, Sparks, Donald L., Advisory Editor, Pluschke, Peter, editor, and Schleibinger, Hans, editor

Published
2018
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39. Science and policy on endocrine disrupters must not be mixed: a reply to a common sense intervention by toxicology journal editors.

Author

Bergman, Åke, Andersson, Anna-Maria, Becher, Georg, van den Berg, Martin, Iguchi, Taisen, Hass, Ulla, Jobling, Susan, Juul, Anders, Kidd, Karen, Kortenkamp, Andreas, Lind, Monica, Martin, Olwenn, Muir, Derek, Ochieng, Roseline, Olea, Nicolas, Norrgren, Leif, Ropstad, Erik, Ross, Peter, Rudén, Christina, Scheringer, Martin, Skakkebaek, Niels, Söder, Olle, Sonnenschein, Carlos, Soto, Ana, Swan, Shanna, Toppari, Jorma, Tyler, Charles, Vandenberg, Laura, Vinggaard, Anne, Wiberg, Karin, Zoeller, R, Bjerregaard, Poul, Bornehag, Carl-Gustaf, Bornman, Riana, Brandt, Ingvar, Brian, Jayne, Casey, Stephanie, Fowler, Paul, Frouin, Heloise, Giudice, Linda, and Blumberg, Bruce

Subjects
Endocrine Disruptors, Environmental Exposure, Environmental Pollutants, European Union, Government Regulation, Health Policy, Humans, Periodicals as Topic, Toxicology
Abstract

The common sense intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.

Published
2013

41. Science and policy on endocrine disrupters must not be mixed: a reply to a �common sense� intervention by toxicology journal editors

Author

Bergman, Åke, Andersson, Anna-Maria, Becher, Georg, van den Berg, Martin, Blumberg, Bruce, Bjerregaard, Poul, Bornehag, Carl-Gustaf, Bornman, Riana, Brandt, Ingvar, Brian, Jayne V, Casey, Stephanie C, Fowler, Paul A, Frouin, Heloise, Giudice, Linda C, Iguchi, Taisen, Hass, Ulla, Jobling, Susan, Juul, Anders, Kidd, Karen A, Kortenkamp, Andreas, Lind, Monica, Martin, Olwenn V, Muir, Derek, Ochieng, Roseline, Olea, Nicolas, Norrgren, Leif, Ropstad, Erik, Ross, Peter S, Rudén, Christina, Scheringer, Martin, Skakkebaek, Niels, Söder, Olle, Sonnenschein, Carlos, Soto, Ana, Swan, Shanna, Toppari, Jorma, Tyler, Charles R, Vandenberg, Laura N, Vinggaard, Anne, Wiberg, Karin, and Zoeller, R

Subjects
Endocrine Disrupting Chemicals, Environment, Health, Precautionary Principle, Regulatory Toxicology
Published
2013

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