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4. The relation between the presence and extent of lobular carcinoma in situ and the risk of local recurrence for patients with infiltrating carcinoma of the breast treated with conservative surgery and radiation therapy

Author

Abner, Anthony L., Connolly, James L., Recht, Abram, Bornstein, Bruce, Nixon, Asa, Hetelekidis, Stella, Silver, Barbara, Harris, Jay R., and Schnitt, Stuart J.

Subjects
Breast cancer -- Complications, Cancer -- Relapse, Chemotherapy -- Evaluation, Radiotherapy -- Evaluation, Health
Published
2000

5. RADIATION THERAPY

Author

FitzGerald, Thomas J., primary, Bishop‐Jodoin, Maryann, additional, Laurie, Fran, additional, Riberdy, Christopher, additional, Aronowitz, Jesse N., additional, Bannon, Elizabeth, additional, Bornstein, Bruce A., additional, Bradford, Carla D., additional, Bushe, Harry, additional, Cicchetti, Maria G., additional, Ding, Linda, additional, Glanzman, Jonathan M., additional, Goff, David J., additional, Herrick, Beth B., additional, Hiatt, Jessica R., additional, Kuo, I‐Lin, additional, Lo, Yuan‐Chyuan, additional, Moni, Janaki, additional, Pieters, Richard S., additional, Rava, Paul S., additional, Sacher, Allison, additional, Saleeby, Jonathan, additional, Sioshansi, Shirin, additional, Ulin, Kenneth, additional, Varlotto, John M., additional, and Wang, Tao, additional

Published
2019
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7. Ten-year results of breast-conserving surgery and definitive irradiation for intraductal carcinoma (ductal carcinoma in situ) of the breast

Author

Solin, Lawrence J., Recht, Abram, Fourquet, Alain, Kurtz, John, Kuske, Robert, McNeese, Marsha, McCormick, Beryl, Cross, Michael A., Schultz, Delray J., Bornstein, Bruce A., Spitalier, Jean-Maurice, Vilcoq, Jacques R., Fowble, Barbara L., Harris, Jay R., and Goodman, Robert L.

Subjects
Breast, Carcinoma, Ductal -- Care and treatment, Carcinoma in situ -- Care and treatment, Breast cancer -- Prognosis, Breast cancer -- Care and treatment, Health
Abstract

Intraductal carcinoma of the breast, also called ductal carcinoma in situ, is a breast cancer that occurs within the breast ducts and has not yet begun to invade the surrounding tissues. Historically, this, like other breast cancers, was treated by mastectomy. However, it has become common to treat intraductal carcinoma of the breast with conservative surgery, followed by irradiation to destroy any cells that might have escaped surgical extirpation. Unfortunately, breast cancer may recur even after many years. It is important, therefore, to evaluate any breast cancer treatment over a long period to gain accurate insight into its effectiveness. Such an evaluation has now been completed; the cases of 259 women treated for intraductal breast cancer were followed-up for an average of 78 months. The actuarial 10-year survival rate was 94 percent, though it should be emphasized that not all the remaining six percent of patients died of cancer. The survival specific for breast cancer was 97 percent over the same period. Recurrences were not rare, however. The 10-year rate of recurrence of cancer within the breast itself was 16 percent, and in the present group of women the recurrences occurred after intervals ranging from 17 to 129 months after the initial treatment. Twenty-four of the 28 women who developed recurrent cancer in the breast were successfully treated; four, however, developed metastatic cancer in distant parts of the body, an essentially incurable condition. The results demonstrate that a high rate of overall survival can be achieved with conservative surgery and irradiation in the treatment of intraductal carcinoma of the breast. However, the results also demonstrate that breast cancer can recur even after long periods of apparent freedom from cancer. Therefore, it is important that breast cancer patients be provided with prolonged and careful follow-up. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

8. Results of treating ductal carcinoma in situ of the breast with conservative surgery and radiation therapy

Author

Bornstein, Bruce A., Recht, Abram, Connolly, James L., Schnitt, Stuart J., Cady, Blake, Koufman, Clinton, Love, Susan, Osteen, Robert T., and Harris, Jay R.

Subjects
Breast cancer, Carcinoma in situ, Health
Abstract

Ductal carcinoma in situ (DCIS) is a breast cancer arising in the ducts that has not yet invaded surrounding tissue. In the past, the specter of breast cancer was sufficiently ominous that virtually all cases of DCIS were treated with mastectomy. This treatment has been reviewed in recent years, in no small part due to the fact that the growth of mammography is turning up larger numbers of DCIS than were ever diagnosed at such an early stage in the past. Breast-conserving surgery is becoming more popular, but experience with breast-conserving surgery for DCIS is still limited. For this reason, the authors report their experience treating DCIS with conservative surgery and radiation therapy during the period from 1976 to 1985. During this period, 38 patients were diagnosed at a median age of 49 years. In 20 of the patients, the tumor was detectable only by mammography. The tumor was surgically removed in all patients and the tumor bed was treated with an average dose of 6,400 cGy of radiation. An important aspect of the treatment of DCIS is the success of salvage treatment if the cancer recurs after the initial surgery and radiotherapy. In the present study, the cancer recurred in eight patients. These patients underwent mastectomy, and all but one are presently free of disease after a follow-up ranging from 1 to 73 months. Reported local recurrence rates for DCIS after mastectomy range from 0 to 2 percent. Mastectomy, therefore, remains the ''gold standard'' against which other treatments are compared. Only the patient can decide how to balance the small but real risks with the palpable benefits of breast-conserving surgery. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

10. Bending the Cost Curve: A Unique Collaboration Between Radiation Oncologists and Blue Cross Blue Shield of Massachusetts to Optimize the Use of Advanced Technology

Author

Steingisser, Lee, primary, Acker, Brian, additional, Berman, Stuart, additional, Brenner, Mark J., additional, Bornstein, Bruce A., additional, Busse, Paul, additional, FitzGerald, Thomas J., additional, Jacobson, Joseph O., additional, Jekowsky, Eliot, additional, Kachnic, Lisa A., additional, Mamon, Harvey, additional, McKee, Andrea, additional, Shulman, Lawrence N., additional, Stevenson, Mary Ann, additional, Wazer, David, additional, and Fallon, John A., additional

Published
2014
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12. Postsurgical Treatment of Early-stage Breast Cancer With Electronic Brachytherapy

Author

Patel, Rakesh R., primary, Beitsch, Peter D., additional, Nichols, Timothy D., additional, Lorenzetti, John D., additional, Wurzer, James C., additional, Tucker, James C., additional, Nunn, George W., additional, Laduzinsky, Susan J., additional, Kugler, Morris A., additional, Simmons, Dwelvin L., additional, Gilligan, Michael S., additional, Roy, Tapan, additional, Foley, Jonathon K., additional, Thropay, John P., additional, Odou, Mark William, additional, Bornstein, Bruce A., additional, Tito, Elizabeth P., additional, Chadha, Manjeet, additional, Boolbol, Susan K., additional, Lane, Steven C., additional, and White, Julie G., additional

Published
2013
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13. Commercializing university biomedical ideas : problems and opportunities

Author

Edward B. Roberts., Sloan School of Management, Bornstein, Bruce Alan, Edward B. Roberts., Sloan School of Management, and Bornstein, Bruce Alan

Abstract

Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 1999., Includes bibliographical references (leaves 89-90)., The level of entrepreneurship and commercialization of inventions at universities in the United States varies widely. This study attempts to uncover the factors that may explain the differences in the attitude toward entrepreneurship and commercialization found at academic institutions. To this end nineteen interviews with faculty researchers, inventors, entrepreneurs, venture capitalists, technology transfer officers, and others were conducted. The different perceptions toward entrepreneurship and commercialization at the Massachusetts Institute of Technology, Harvard University, and Harvard Medical School and its associated research hospitals were examined with particular care. Several factors that are significant in promoting entrepreneurship and interest in the commercialization of ideas were identified. Although these factors may account for the observed differences, no one factor was singled out as being the most important. These factors include the presence of mentors and role models, the composition of the institution's intellectual property, cultural differences, the conflict of interest policy, a critical mass of people, the technology transfer process, and the availability of university venture funds. Many of those interviewed believed that the nature of intellectual property and accessibility to mentors and role models by the researchers and inventors were probably the most significant of all factors for enhancing entrepreneurship., by Bruce A. Bornstein., M.B.A.

Published
2005

36. A phase I–II trial of cisplatin, hyperthermia and radiation in patients with locally advanced malignancies

Author

Herman, Terence S, primary, Jochelson, Maxine S, additional, Teicher, Beverly A, additional, Scott, Pamela J, additional, Hansen, Jorgen, additional, Clark, John R, additional, Pfeffer, M.Raphael, additional, Gelwan, Lise E, additional, Molnar-Griffin, Beverly J, additional, Fraser, Suzette M, additional, Svennson, Goran, additional, Bornstein, Bruce A, additional, Ryan, L, additional, and Coleman, C.Norman, additional

Published
1989
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