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37 results on '"Bort, Alicia"'

4. Diabetic individuals with COVID-19 exhibit reduced efficacy of gliptins in inhibiting dipeptidyl peptidase 4 (DPP4). A suggested explanation for increased COVID-19 susceptibility in patients with type 2 diabetes mellitus (T2DM)

Author

Mora-Rodríguez, José María, primary, Sánchez, Belén G., additional, Bort, Alicia, additional, Díaz-Yuste, Alba, additional, Ballester-González, Rubén, additional, Arrieta, Francisco, additional, Sebastián-Martín, Alba, additional, and Díaz-Laviada, Inés, additional

Published
2023
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5. Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

Author

Mora-Rodríguez, José María, primary, Sánchez, Belén G., additional, Sebastián-Martín, Alba, additional, Díaz-Yuste, Alba, additional, Sánchez-Chapado, Manuel, additional, Palacín, Ana María, additional, Sánchez-Rodríguez, Carlos, additional, Bort, Alicia, additional, and Díaz-Laviada, Inés, additional

Published
2023
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23. MOESM1 of Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Author

Sánchez, Belén, Bort, Alicia, Mateos-Gómez, Pedro, Rodríguez-Henche, Nieves, and Díaz-Laviada, Inés

Subjects
urologic and male genital diseases, neoplasms
Abstract

Additional file 1: Figure S1. Isobologram and combination index (CI) of the combined treatment (DTX + CAP) inhibitory effect on LNCaP and PC3 xenograft tumor growth.

Published
2019
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31. Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation

Author

Bort, Alicia, primary, Quesada, Sergio, additional, Ramos-Torres, Ágata, additional, Gargantilla, Marta, additional, Priego, Eva María, additional, Raynal, Sophie, additional, Lepifre, Franck, additional, Gasalla, Jose M., additional, Rodriguez-Henche, Nieves, additional, Castro, Ana, additional, and Díaz-Laviada, Inés, additional

Published
2018
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36. Hierarchical Self-Assembly of BODIPY Dyes as a Tool to Improve the Antitumor Activity of Capsaicin in Prostate Cancer.

Author

Sampedro A, Ramos-Torres Á, Schwöppe C, Mück-Lichtenfeld C, Helmers I, Bort A, Díaz-Laviada I, and Fernández G

Subjects
Animals, Antineoplastic Agents chemistry, Boron Compounds chemical synthesis, Capsaicin chemistry, Cell Proliferation drug effects, Cell Survival drug effects, Drug Screening Assays, Antitumor, Fluorescent Dyes chemical synthesis, Humans, Male, Mice, Models, Molecular, Molecular Structure, Neoplasms, Experimental drug therapy, Neoplasms, Experimental pathology, PC-3 Cells, Prostatic Neoplasms pathology, Antineoplastic Agents pharmacology, Boron Compounds chemistry, Capsaicin pharmacology, Fluorescent Dyes chemistry, Prostatic Neoplasms drug therapy
Abstract

Capsaicin (CAP) has been long known for its analgesic properties and more recently for its antitumor activity in various cell types. However, its pungency and the high doses needed to achieve a significant activity have precluded its application in cancer therapy. Herein, we propose a straightforward novel strategy to improve the antitumor effect of CAP based on the enhancement of its aggregation propensity in aqueous media by covalent attachment of a BODIPY (BDP) dye. The target CAP-BDP 1 self-assembles in aqueous solutions into weakly fluorescent globular assemblies that become highly emissive upon cell uptake-induced disassembly. Remarkably, due to the improved delivery to the tumour tissue upon aggregation, we have succeeded in reducing the doses of CAP-based drugs in vivo in prostate cancer by two orders of magnitude while maintaining a substantial antitumor activity., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2018
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37. The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells.

Author

Ramos-Torres Á, Bort A, Morell C, Rodríguez-Henche N, and Díaz-Laviada I

Subjects
Antineoplastic Agents, Phytogenic isolation & purification, Antioxidants pharmacology, Apoptosis drug effects, Capsaicin isolation & purification, Capsicum chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Humans, Lysosomes drug effects, Lysosomes metabolism, Male, Microtubule-Associated Proteins metabolism, Phosphatidylinositol 3-Kinase metabolism, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, Proto-Oncogene Proteins c-akt metabolism, Reactive Oxygen Species metabolism, Signal Transduction drug effects, TOR Serine-Threonine Kinases metabolism, Time Factors, Antineoplastic Agents, Phytogenic pharmacology, Autophagy drug effects, Capsaicin pharmacology, Prostatic Neoplasms drug therapy
Abstract

Capsaicin, the pungent ingredient of red hot chili peepers, has been shown to have anti-cancer activities in several cancer cells, including prostate cancer. Several molecular mechanisms have been proposed on its chemopreventive action, including ceramide accumulation, endoplasmic reticulum stress induction and NFκB inhibition. However, the precise mechanisms by which capsaicin exerts its anti-proliferative effect in prostate cancer cells remain questionable. Herein, we have tested the involvement of autophagy on the capsaicin mechanism of action on prostate cancer LNCaP and PC-3 cells.The results showed that capsaicin induced prostate cancer cell death in a time- and concentration-dependent manner, increased the levels of microtubule-associated protein light chain 3-II (LC3-II, a marker of autophagy) and the accumulation of the cargo protein p62 suggesting an autophagy blockage. Moreover, confocal microscopy revealed that capsaicin treatment increased lysosomes which co-localized with LC3 positive vesicles in a similar extent to that produced by the lysosomal protease inhibitors E64 and pepstatin pointing to an autophagolysosomes breakdown inhibition. Furthermore, we found that capsaicin triggered ROS generation in cells, while the levels of ROS decreased with N-acetyl-cysteine (NAC), a ROS scavenger. Co-treatment of cells with NAC and capsaicin abrogated the effects of capsaicin on autophagy and cell death. Normal prostate PNT2 and RWPE-1 cells were more resistant to capsaicin-induced cytotoxicity and did not accumulate p62 protein.Taken together, these results suggest that ROS-mediated capsaicin-induced autophagy blockage contributes to antiproliferation in prostate cancer cells, which provides new insights into the anticancer molecular mechanism of capsaicin.

Published
2016
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