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Occupational therapy pre-registration education stands at the intersection of the fields of health and social care and higher education. UK Government agendas in both fields have seen an increase in the number of students entering with non-traditional academic backgrounds, a group noted to experience particular challenges in negotiating the transition to, and persisting and succeeding within, higher education. Drawing on data from an ongoing longitudinal case study, a Bourdieuian lens is applied to exploring the early educational experiences of a group of these students during their first year of study and highlights a number of key issues, including the high-value status of linguistic capital and its relationship to understanding the rules governing practices within the learning environment, the processes via which students manage to adapt to or interestingly, to resist, the dominant culture of the field, and some of the barriers to finding a foothold and legitimate position within the new field. (Contains 1 figure and 1 table.)

Spontaneous and induced uterine contractions in the rat were found to be inhibited by a novel and selective oxytocin receptor antagonist GSK221149A (3R,6R)-3-Indan-2-yl-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4- yl-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedi-one. GSK221149A displayed nanomolar affinity ([K.sub.i] = 0.65 nM) for human recombinant oxytocin receptors with >l,400-fold selectivity over human Via, Vlb, and V2 receptors. GSK221149A had similar affinity ([K.sub.i] = 4.1 nM) and selectivity for native oxytocin receptors from rat and produced a functional, competitive block of oxytocininduced contractions in isolated rat myometrial strips with a [pA.sub.2] value of 8.18. Intravenous administration of GSK221149A produced a dose-dependent decrease in oxytocin-induced uterine contractions in anesthetized rats with an [ID.sub.50] = 0.27 [+ or -] 0.60 mg/kg (corresponding plasma concentrations were 88 ng/ml). Oral administration of GSK221149A (5 mg/kg) was effective in inhibiting oxytocin-induced uterine contractions after single and multiple (4-day) dosing. Spontaneous uterine contractions in late-term pregnant rats (19-21 days gestation) were significantly reduced by intravenous administration of 0.3 mg/kg of GSK221149A. These results provide further evidence that selective oxytocin receptor antagonism may offer an effective treatment for preterm labor. preterm labor; myometrium doi: 10.1152/ajpregu.00057.2007

A study examining the factors that have influenced the changes in workforce of healthcare sector is presented. It is observed that quite often, its consumer preferences rather than profession-led services that have affected the workforce.