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154 results on '"Borys, Damian"'

1. Towards the use of multiple ROIs for radiomics-based survival modelling: finding a strategy of aggregating lesions

Author

Wilk, Agata Małgorzata, Swierniak, Andrzej, d'Amico, Andrea, Suwiński, Rafał, Fujarewicz, Krzysztof, and Borys, Damian

Subjects
Statistics - Applications
Abstract

Background. Radiomic features, derived from a region of interest (ROI) in medical images, are valuable as prognostic factors. Selecting an appropriate ROI is critical, and many recent studies have focused on leveraging multiple ROIs by segmenting analogous regions across patients - such as the primary tumour and peritumoral area or subregions of the tumour. These can be straightforwardly incorporated into models as additional features. However, a more complex scenario arises for example in a regionally disseminated disease, when multiple distinct lesions are present. Aim. This study aims to evaluate the feasibility of integrating radiomic data from multiple lesions into survival models. We explore strategies for incorporating these ROIs and hypothesise that including all available lesions can improve model performance. Methods. While each lesion produces a feature vector, the desired result is a unified prediction. We propose methods to aggregate either the feature vectors to form a representative ROI or the modeling results to compute a consolidated risk score. As a proof of concept, we apply these strategies to predict distant metastasis risk in a cohort of 115 non-small cell lung cancer patients, 60% of whom exhibit regionally advanced disease. Two feature sets (radiomics extracted from PET and PET interpolated to CT resolution) are tested across various survival models using a Monte Carlo Cross-Validation framework. Results. Across both feature sets, incorporating all available lesions - rather than limiting analysis to the primary tumour - consistently improved the c-index, irrespective of the survival model used. Conclusion. Lesions beyond the primary tumour carry information that should be utilised in radiomics-based models to enhance predictive ability., Comment: To be submitted to Computer Methods and Programs in Biomedicine

Published
2024

4. Feasibility of the J-PET to monitor range of therapeutic proton beams

Author

Baran, Jakub, Borys, Damian, Brzeziński, Karol, Gajewski, Jan, Silarski, Michał, Chug, Neha, Coussat, Aurélien, Czerwiński, Eryk, Dadgar, Meysam, Dulski, Kamil, Eliyan, Kavya V., Kacprzak, Aleksander Gajos Krzysztof, Kapłon, Łukasz, Klimaszewski, Konrad, Konieczka, Paweł, Kopeć, Renata, Korcyl, Grzegorz, Kozik, Tomasz, Krzemień, Wojciech, Kumar, Deepak, Lomax, Antony J., McNamara, Keegan, Niedźwiecki, Szymon, Olko, Paweł, Panek, Dominik, Parzych, Szymon, del Rio, Elena Perez, Raczyński, Lech, Simbarashe, Moyo, Sharma, Sushil, Shivani, Shopa, Roman Y., Skóra, Tomasz, Skurzok, Magdalena, Stasica, Paulina, Stępień, Ewa Ł., Tayefi, Keyvan, Tayefi, Faranak, Weber, Damien C., Winterhalter, Carla, Wiślicki, Wojciech, Moskal, Pawel, and Rucinski, Antoni

Subjects
Physics - Medical Physics
Abstract

Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment. Main results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10$^{-5}$ coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for the future clinical application. Experimental tests are needed to confirm these findings., Comment: 19 pages, 7 pages

Published
2023

5. Improving the Predictive Ability of Radiomics-Based Regression Survival Models Through Incorporating Multiple Regions of Interest

Author

Wilk, Agata Małgorzata, Kozłowska, Emilia, Borys, Damian, D’Amico, Andrea, Gorczewska, Izabela, Debosz-Suwińska, Iwona, Gałecki, Seweryn, Fujarewicz, Krzysztof, Suwiński, Rafał, Świerniak, Andrzej, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Strumiłło, Paweł, editor, Klepaczko, Artur, editor, Strzelecki, Michał, editor, and Bociąga, Dorota, editor

Published
2024
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6. The OpenGATE ecosystem for Monte Carlo simulation in medical physics

Author

Sarrut, David, Arbor, Nicolas, Baudier, Thomas, Borys, Damian, Etxebeste, Ane, Fuchs, Hermann, Gajewski, Jan, Grevillot, Loïc, Jan, Sébastien, Kagadis, George C, Kang, Han Gyu, Kirov, Assen, Kochebina, Olga, Krzemien, Wojciech, Lomax, Antony, Papadimitroulas, Panagiotis, Pommranz, Christian, Roncali, Emilie, Rucinski, Antoni, Winterhalter, Carla, and Maigne, Lydia

Subjects
Medical and Biological Physics, Physical Sciences, Cancer, Computer Simulation, Ecosystem, Monte Carlo Method, Physics, Software, Monte Carlo, Gate, Geant4, simulation, Other Physical Sciences, Biomedical Engineering, Clinical Sciences, Nuclear Medicine & Medical Imaging, Medical and biological physics
Abstract

This paper reviews the ecosystem of GATE, an open-source Monte Carlo toolkit for medical physics. Based on the shoulders of Geant4, the principal modules (geometry, physics, scorers) are described with brief descriptions of some key concepts (Volume, Actors, Digitizer). The main source code repositories are detailed together with the automated compilation and tests processes (Continuous Integration). We then described how the OpenGATE collaboration managed the collaborative development of about one hundred developers during almost 20 years. The impact of GATE on medical physics and cancer research is then summarized, and examples of a few key applications are given. Finally, future development perspectives are indicated.

Published
2022

7. Improving the Predictive Ability of Radiomics-Based Regression Survival Models Through Incorporating Multiple Regions of Interest

Author

Wilk, Agata Małgorzata, primary, Kozłowska, Emilia, additional, Borys, Damian, additional, D’Amico, Andrea, additional, Gorczewska, Izabela, additional, Debosz-Suwińska, Iwona, additional, Gałecki, Seweryn, additional, Fujarewicz, Krzysztof, additional, Suwiński, Rafał, additional, and Świerniak, Andrzej, additional

Published
2023
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8. Potential of Radiomics Features for Predicting Time to Metastasis in NSCLC

Author

Wilk, Agata, Borys, Damian, Fujarewicz, Krzysztof, d’Amico, Andrea, Suwiński, Rafał, Świerniak, Andrzej, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nguyen, Ngoc Thanh, editor, Tran, Tien Khoa, editor, Tukayev, Ualsher, editor, Hong, Tzung-Pei, editor, Trawiński, Bogdan, editor, and Szczerbicki, Edward, editor

Published
2022
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9. Machine Learning Approach to Predict Metastasis in Lung Cancer Based on Radiomic Features

Author

Fujarewicz, Krzysztof, Wilk, Agata, Borys, Damian, d’Amico, Andrea, Suwiński, Rafał, Świerniak, Andrzej, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nguyen, Ngoc Thanh, editor, Tran, Tien Khoa, editor, Tukayev, Ualsher, editor, Hong, Tzung-Pei, editor, Trawiński, Bogdan, editor, and Szczerbicki, Edward, editor

Published
2022
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10. GATE Monte Carlo simulation toolkit for medical physics

Author

Kochebina Olga, Sarrut David, Arbor Nicolas, Baudier Thomas, Borys Damian, Favaretto Martina, Etxebeste Ane, Fuchs Hermann, Gajewski Jan, Grevillot Loïc, Jacquet Maxime, Jan Sébastien, Kagadis George C., Kang Han Gyu, Kirov Assen, Krah Nils, Krzemien Wojciech, Lomax Antony, Papadimitroulas Panagiotis, Pereda Alexis, Pommranz Christian, Resch Andreas, Roncali Emilie, Rucinski Antoni, Winterhalter Carla, and Maigne Lydia

Subjects
Physics, QC1-999
Abstract

The GATE toolkit (GEANT4 Application for Tomographic Emission) is a GEANT4-based (GEometry ANd Tracking) platform for Monte Carlo simulations in medical physics. GATE applications can be divided into two main axes: radiation-based medical imaging and radiotherapy/dosimetry. The accurate modeling of the first one is crucial for system design and optimization as well as for development and refinement of image analysis algorithms. The importance of the precise simulation of the second is essential for characterisation of external beam radiotherapy (proton therapy and carbon ion therapy) and absorbed dose assessment. Within this paper, we discuss the main features of GATE and give a general view on applications, followed by insights into future development perspectives.

Published
2024
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15. Evaluation of the MRI Images Matching Using Normalized Mutual Information Method and Preprocessing Techniques

Author

Bzowski, Paweł, Borys, Damian, Guz, Wiesław, Obuchowicz, Rafał, Piórkowski, Adam, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Choraś, Michał, editor, and Choraś, Ryszard S., editor

Published
2020
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16. BioTest - Remote Platform for Hypothesis Testing and Analysis of Biomedical Data

Author

Psiuk-Maksymowicz, Krzysztof, Jaksik, Roman, Placzek, Aleksander, Gruca, Aleksandra, Student, Sebastian, Borys, Damian, Mrozek, Dariusz, Fujarewicz, Krzysztof, Swierniak, Andrzej, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Korbicz, Józef, editor, Maniewski, Roman, editor, Patan, Krzysztof, editor, and Kowal, Marek, editor

Published
2020
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18. Games with Resources and Their Use in Modeling Effects of Anticancer Treatment

Author

Swierniak, Andrzej, Krzeslak, Michal, Borys, Damian, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Pietka, Ewa, editor, Badura, Pawel, editor, Kawa, Jacek, editor, and Wieclawek, Wojciech, editor

Published
2019
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19. Rigid and Non-rigid Registration Algorithm Evaluation in MRI for Breast Cancer Therapy Monitoring

Author

Bzowski, Paweł, Danch-Wierzchowska, Marta, Psiuk-Maksymowicz, Krzysztof, Panek, Rafał, Borys, Damian, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Pietka, Ewa, editor, Badura, Pawel, editor, Kawa, Jacek, editor, and Wieclawek, Wojciech, editor

Published
2019
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20. Tumor Texture Analysis in PET: Relationship Between the Level of Uptake of Radio-Label at the Time of Treatment and the Level of Uptake of Radio-Label Before and After Treatment

Author

Juraszczyk, Aleksandra, Gorczewski, Kamil, Borys, Damian, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio, Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Gzik, Marek, editor, Tkacz, Ewaryst, editor, Paszenda, Zbigniew, editor, and Piętka, Ewa, editor

Published
2017
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21. Trends in Biomechanical Finite Element Breast Deformation Modelling

Author

Danch-Wierzchowska, Marta, Gorczewski, Kamil, Borys, Damian, Swierniak, Andrzej, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio, Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Gzik, Marek, editor, Tkacz, Ewaryst, editor, Paszenda, Zbigniew, editor, and Piętka, Ewa, editor

Published
2017
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22. Scalability of a Genomic Data Analysis in the BioTest Platform

Author

Psiuk-Maksymowicz, Krzysztof, Mrozek, Dariusz, Jaksik, Roman, Borys, Damian, Fujarewicz, Krzysztof, Swierniak, Andrzej, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Nguyen, Ngoc Thanh, editor, Tojo, Satoshi, editor, Nguyen, Le Minh, editor, and Trawiński, Bogdan, editor

Published
2017
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27. A Holistic Approach to Testing Biomedical Hypotheses and Analysis of Biomedical Data

Author

Psiuk-Maksymowicz, Krzysztof, Płaczek, Aleksander, Jaksik, Roman, Student, Sebastian, Borys, Damian, Mrozek, Dariusz, Fujarewicz, Krzysztof, Świerniak, Andrzej, Diniz Junqueira Barbosa, Simone, Series editor, Chen, Phoebe, Series editor, Du, Xiaoyong, Series editor, Filipe, Joaquim, Series editor, Kara, Orhun, Series editor, Liu, Ting, Series editor, Kotenko, Igor, Series editor, Sivalingam, Krishna M., Series editor, Washio, Takashi, Series editor, Kozielski, Stanisław, editor, Mrozek, Dariusz, editor, Kasprowski, Paweł, editor, Małysiak-Mrozek, Bożena, editor, and Kostrzewa, Daniel, editor

Published
2016
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28. Integrated System Supporting Research on Environment Related Cancers

Author

Bensz, Wojciech, Borys, Damian, Fujarewicz, Krzysztof, Herok, Kinga, Jaksik, Roman, Krasucki, Marcin, Kurczyk, Agata, Matusik, Kamil, Mrozek, Dariusz, Ochab, Magdalena, Pacholczyk, Marcin, Pieter, Justyna, Puszynski, Krzysztof, Psiuk-Maksymowicz, Krzysztof, Student, Sebastian, Swierniak, Andrzej, Smieja, Jaroslaw, Kacprzyk, Janusz, Series editor, Król, Dariusz, editor, Madeyski, Lech, editor, and Nguyen, Ngoc Thanh, editor

Published
2016
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32. Feasibility of the J-PET to monitor the range of therapeutic proton beams

Author

Baran, Jakub, Borys, Damian, Brzeziński, Karol, Gajewski, Jan, Silarski, Michał, Chug, Neha, Coussat, Aurélien, Czerwiński, Eryk, Dadgar, Meysam, Dulski, Kamil, Eliyan, Kavya V., Gajos, Aleksander, Kacprzak, Krzysztof, Kapłon, Łukasz, Klimaszewski, Konrad, Konieczka, Paweł, Kopeć, Renata, Korcyl, Grzegorz, Kozik, Tomasz, Krzemień, Wojciech, Kumar, Deepak, Lomax, Antony J., McNamara, Keegan, Niedźwiecki, Szymon, Olko, Paweł, Panek, Dominik, Parzych, Szymon, Perez del Rio, Elena, Raczyński, Lech, Simbarashe, Moyo, Sharma, Sushil, Shivani, Shopa, Roman Y., Skóra, Tomasz, Skurzok, Magdalena, Stasica, Paulina, Stępień, Ewa Ł., Tayefi, Keyvan, Tayefi, Faranak, Weber, Damien C., Winterhalter, Carla, Wiślicki, Wojciech, Moskal, Paweł, and Ruciński, Antoni

Published
2024
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34. Automatic Segmentation System of Emission Tomography Data Based on Classification System

Author

Student, Sebastian, Danch-Wierzchowska, Marta, Gorczewski, Kamil, Borys, Damian, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Istrail, Sorin, Series editor, Pevzner, Pavel, Series editor, Waterman, Michael S., Series editor, Ortuño, Francisco, editor, and Rojas, Ignacio, editor

Published
2015
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35. A Simple Hair Removal Algorithm from Dermoscopic Images

Author

Borys, Damian, Kowalska, Paulina, Frackiewicz, Mariusz, Ostrowski, Ziemowit, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Istrail, Sorin, Series editor, Pevzner, Pavel, Series editor, Waterman, Michael S., Series editor, Ortuño, Francisco, editor, and Rojas, Ignacio, editor

Published
2015
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42. Postępy w onkologii obliczeniowej i spersonalizowanej medycynie. T. 2, Wyzwania przyszłości

Author

Adamiec-Organiściok, Małgorzata, Bartnicka, Joanna, Bernyś, Michał, Białecki, Ryszard, Bojar, Piotr, Borys, Damian, Bugdol, Monika, Choiński, Dariusz, Frąckiewicz, Mariusz, Gil, Jarosław, Głowacki, Jan, Gogler-Pigłowska, Agnieszka, Gracka, Maria, Herrera, Cristina, Hudecki, Andrzej, Hybiak, Jolanta, Jankowska, Kornelia, Jędrzejowski, Maksymilian, Juszczyk, Jan, Kabiesz, Patrycja, Kalisz, Seweryn, Kania, Mateusz, Kipsang, Benard, Kostka, Daria, Kowol, Karolina, Krukiewicz, Katarzyna, Langer-Macioł, Hanna, Lucińska, Kinga, Łos, Marek J., Majchrzak, Ewa, Marczyk, Michał, Melka, Bartłomiej, Mleczko, Katarzyna, Ostrowski, Ziemowit, Patel, Taral, Peters, Harm, Piętka, Ewa, Płonka, Wiktoria, Polańska, Joanna, Polański, Andrzej, Prażuch, Wojciech, Psiuk-Maksymowicz, Krzysztof, Pyciński, Bartłomiej, Rojczyk, Marek, Rutto, Wesley Chebii, San Martin Valenzuela, Constanza, Sieradzka, Katarzyna, Sikora, Wojciech, Skonieczna, Magdalena, Skorupa, Małgorzata, Skupin, Piotr, Socha, Marek, Sojka, Damian, Staśczak, Alicja, Strózik, Barbara, Student, Sebastian, Suwalska, Aleksandra, Szymiczek, Krzysztof, Ścieglińska, Dorota, Śliwińska, Wiktoria, Tobiasz, Joanna, Wasilewski, Jarosław, Wencel, Przemysław, Widzisz, Karolina, Wilczek, Piotr, Ziętkiewicz, Agnieszka, POLCOVID Study Group, Krukiewicz, Katarzyna. Red., Marczyk, Michał. Red., Bugdol, Monika. Red., Bajkacz, Sylwia. Red., Ostrowski, Ziemowit. Red., and Polańska, Joanna. Red. serii

Subjects
bioinformatyka, onkologia obliczeniowa, medycyna spersonalizowana, modelowanie numeryczne, e-learning, biomateriały
Published
2023
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43. Numerical modeling of blood flow in bifurcation and trifurcation geometries use of different boundary conditions

Author

Bernyś, Michał, Melka, Bartłomiej, Gracka, Maria, Ostrowski, Ziemowit, Rojczyk, Marek, Psiuk-Maksymowicz, Krzysztof, Borys, Damian, Wasilewski, Jarosław, Głowacki, Jan, and Białecki, Ryszard

Subjects
onkologia obliczeniowa, naczynia wieńcowe, bifurkacja, przepływ krwi, obliczeniowa mechanika płynów, trifurkacja, medycyna spersonalizowana, modelowanie numeryczne
Published
2023
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46. ProTheRaMon—a GATE simulation framework for proton therapy range monitoring using PET imaging

Author

Borys, Damian, Baran, Jakub, Brzeziński, Karol, Gajewski, Jan, Chug, Neha, Coussat, Aurelien, Czerwiński, Eryk, Dadgar, Meysam, Dulski, Kamil, Eliyan, Kavya V., Gajos, Aleksander, Kacprzak, Krzysztof, Kapłon, Łukasz, Klimaszewski, Konrad, Konieczka, Paweł, Kopeć, Renata, Korcyl, Grzegorz, Kozik, Tomasz, Krzemien, Wojciech, Kumar, Deepak, Lomax, Antony J., McNamara, Keegan, and Winterhalter, Carla

Subjects
proton therapy, GATE, Monte Carlo simulations, J-PET, medical imaging
Abstract

Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user’s needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022)., Physics in Medicine and Biology, 67 (22), ISSN:1361-6560, ISSN:0031-9155

Published
2022

47. GPU accelerated Monte Carlo scoring of positron emitting isotopes produced during proton therapy for PET verification

Author

McNamara, Keegan, primary, Schiavi, Angelo, additional, Borys, Damian, additional, Brzezinski, Karol, additional, Gajewski, Jan, additional, Kopeć, Renata, additional, Rucinski, Antoni, additional, Skóra, Tomasz, additional, Makkar, Shubhangi, additional, Hrbacek, Jan, additional, Weber, Damien C, additional, Lomax, Antony J, additional, and Winterhalter, Carla, additional

Published
2022
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