98,210 results on '"Bos, A"'
Search Results
2. Learning in a Multifield Coherent Ising Machine
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de Bos, Daan and Serra-Garcia, Marc
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Disordered Systems and Neural Networks ,Computer Science - Emerging Technologies ,Computer Science - Neural and Evolutionary Computing ,Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
Physical information processors can learn from examples if they are modified according to an abstract parameter update equation, termed a learning rule. We introduce a physical model for self-learning that encodes the learning rule in the Hamiltonian of the system. The model consists of a network of multi-modal resonators. One of the modes is driven parametrically into a bi-stable regime, forming a coherent Ising machine (CIM) -- that provides the long-term memory that stores learned responses (weights). The CIM is augmented with an additional spinor field that acts as short-term (activation) memory. We numerically demonstrate that, in the presence of suitable nonlinear interactions between the long-term memory Ising machine and the short-term memory auxiliary field, the system autonomously learns from examples., Comment: 8 pages, 4 figures
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- 2025
3. MyDigiTwin: A Privacy-Preserving Framework for Personalized Cardiovascular Risk Prediction and Scenario Exploration
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Cadavid, Héctor, Mo, Hyunho, Arends, Bauke, Dziopa, Katarzyna, Bron, Esther E., Bos, Daniel, Georgievska, Sonja, and van der Harst, Pim
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Computer Science - Machine Learning ,Computer Science - Human-Computer Interaction - Abstract
Cardiovascular disease (CVD) remains a leading cause of death, and primary prevention through personalized interventions is crucial. This paper introduces MyDigiTwin, a framework that integrates health digital twins with personal health environments to empower patients in exploring personalized health scenarios while ensuring data privacy. MyDigiTwin uses federated learning to train predictive models across distributed datasets without transferring raw data, and a novel data harmonization framework addresses semantic and format inconsistencies in health data. A proof-of-concept demonstrates the feasibility of harmonizing and using cohort data to train privacy-preserving CVD prediction models. This framework offers a scalable solution for proactive, personalized cardiovascular care and sets the stage for future applications in real-world healthcare settings.
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- 2025
4. Materials design criteria for ultra-high thermoelectric power factors in metals
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Graziosi, Patrizio, Mehnert, Kim-Isabelle, Dutt, Rajeev, Bos, Jan-Willem G., and Neophytou, Neophytos
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Condensed Matter - Materials Science - Abstract
Metals have high electronic conductivities, but very low Seebeck coefficients, which traditionally make them unsuitable for thermoelectric materials. Recent studies, however, showed that metals can deliver ultra-high thermoelectric power factors (PFs) under certain conditions. In this work, we theoretically examine the electronic structure and electronic transport specifications which allow for such high PFs. Using Boltzmann transport (BTE) simulations and a multi-band electronic structure model, we show that metals with: i) high degree of transport asymmetry between their bands, ii) strong inter-band scattering, and iii) a large degree of band overlap, can provide ultra-high power factors. We show that each of these characteristics adds to the steepness of the transport distribution function of the BTE, which allows for an increase of the Seebeck coefficient to sizable values, simultaneously with an increase in the electrical conductivity. This work generalizes the concept that transport asymmetry (i.e., mixture of energy regions of high and low contributions to the electrical conductivity), through a combination of different band masses, scattering strengths, or energy filtering scenarios, etc., can indeed result in very high thermoelectric power factors, even in the absence of a material bandgap. Under certain conditions, transport asymmetry can over-compensate any performance degradation to the PF due to bipolar conduction and the naturally low Seebeck coefficients that otherwise exist in this class of materials., Comment: paper and supporting information, 50 pages
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- 2025
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5. The MAJORANA DEMONSTRATOR experiment's construction, commissioning, and performance
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Abgrall, N., Aguayo, E., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Barton, P. J., Bertrand, F. E., Blalock, E., Bos, B., Boswell, M., Bradley, A. W., Brudanin, V., Burritt, T. H., Busch, M., Buuck, M., Byram, D., Caldwell, A. S., Caldwell, T. S., Chan, Y. -D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Combs, D. C., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Fast, J. E., Finnerty, P., Fraenkle, F. M., Fuad, N., Fuller, E., Gilliss, T., Giovanetti, G. K., Goett, J., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Harper, G. C., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Howe, M. A., Jasinski, B. R., Keeter, K. J., Kidd, M. F., Kim, I., Kouzes, R. T., LaFerriere, B. D., Lannen V, T. E., Li, A., Loach, J. C., Lopez, A. M., Lopez-Castano, J. M., MacMullin, J., MacMullin, S., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Merriman, J. H., Mertens, S., Miley, H. S., Myslik, J., Oli, T. K., Orrell, J. L., O'Shaughnessy, C., Othman, G., Overman, N. R., Peterson, D., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Robertson, R. G. H., Rodriguez, L., Ruof, N. W., Salazar, H., Schaper, D. C., Schleich, S. J., Shanks, B., Shirchenko, M., Snavely, K. J., Snyder, N., Soin, A., Steele, D., Suriano, A. M., Swift, G., Trimble, D. Tedeschi J. E., Turqueti, M., Van Wechel, T. D., Varner, R. L., Vasilyev, S., Vorren, K., Watkins, S. L., White, B. R., Wilkerson, J. F., Wiseman, C., Xu, W., Yaver, H., Yu, C. -H., Yumatov, V. I., Zhitnikov, I., and Zhu, B. X.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
Background: The MAJORANA DEMONSTRATOR , a modular array of isotopically enriched high-purity germanium (HPGe) detectors, was constructed to demonstrate backgrounds low enough to justify building a tonne-scale experiment to search for the neutrinoless double-beta decay ($\beta\beta(0\nu)$) of $^{76}\mathrm{Ge}$. Purpose: This paper presents a description of the instrument, its commissioning, and operations. It covers the electroforming, underground infrastructure, enrichment, detector fabrication, low-background and construction techniques, electronics, data acquisition, databases, and data processing of the MAJORANA DEMONSTRATOR. Method: The MAJORANA DEMONSTRATOR operated inside an ultra-low radioactivity passive shield at the 4850-foot~level of the Sanford Underground Research Facility (SURF) from 2015-2021. Results and Conclusions: The MAJORANA DEMONSTRATOR achieved the best energy resolution and second-best background level of any $\beta\beta(0\nu)$ search. This enabled it to achieve an ultimate half-life limit on $\beta\beta(0\nu)$ in $^{76}\mathrm{Ge}$ of $8.3\times 10^{25}$~yr (90\% C.L.) and perform a rich set of searches for other physics beyond the Standard Model., Comment: 72 pages
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- 2025
6. Multifractal Terrain Generation for Evaluating Autonomous Off-Road Ground Vehicles
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Majhor, Casey D. and Bos, Jeremy P.
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Computer Science - Robotics - Abstract
We present a multifractal artificial terrain generation method that uses the 3D Weierstrass-Mandelbrot function to control roughness. By varying the fractal dimension used in terrain generation across three different values, we generate 60 unique off-road terrains. We use gradient maps to categorize the roughness of each terrain, consisting of low-, semi-, and high-roughness areas. To test how the fractal dimension affects the difficulty of vehicle traversals, we measure the success rates, vertical accelerations, pitch and roll rates, and traversal times of an autonomous ground vehicle traversing 20 randomized straight-line paths in each terrain. As we increase the fractal dimension from 2.3 to 2.45 and from 2.45 to 2.6, we find that the median area of low-roughness terrain decreases 13.8% and 7.16%, the median area of semi-rough terrain increases 11.7% and 5.63%, and the median area of high-roughness terrain increases 1.54% and 3.33%, all respectively. We find that the median success rate of the vehicle decreases 22.5% and 25% as the fractal dimension increases from 2.3 to 2.45 and from 2.45 to 2.6, respectively. Successful traversal results show that the median root-mean-squared vertical accelerations, median root-mean-squared pitch and roll rates, and median traversal times all increase with the fractal dimension., Comment: This work has been accepted for publication in ASME Journal of Autonomous Vehicles and Systems
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- 2025
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7. Rare multi-nucleon decays with the full data sets of the Majorana Demonstrator
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Blalock, E., Bos, B., Busch, M., Chan, Y. -D., Chapman, J. R., Christofferson, C. D., Chu, P. -H., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Fuad, N., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Henning, R., Hoppe, E. W., Kouzes, R. T., Li, A., Massarczyk, R., Meijer, S. J., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Schaper, D. C., Schleich, S. J., Tedeschi, D., Varner, R. L., Vasilyev, S., Watkins, S. L., Wilkerson, J. F., Wiseman, C., and Yu, C. -H.
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Nuclear Experiment - Abstract
The Majorana Demonstrator was an ultra-low-background experiment designed for neutrinoless double-beta decay ($0\nu\beta\beta$) investigation in $^{76}$Ge. Located at the Sanford Underground Research Facility in Lead, South Dakota, the Demonstrator utilized modular high-purity Ge detector arrays within shielded vacuum cryostats, operating deep underground. The arrays, with a capacity of up to 40.4 kg (27.2 kg enriched to $\sim 88\%$ in $^{76}$Ge), have accumulated the full data set, totaling 64.5 kg yr of enriched active exposure and 27.4 kg yr of exposure for natural detectors. Our updated search improves previously explored three-nucleon decay modes in Ge isotopes, setting new half-life limits of $1.27\times10^{26}$ years (90\% confidence level) for $^{76}$Ge($ppp$) $\rightarrow$ $^{73}$Cu e$^+\pi^+\pi^+$ and $^{76}$Ge($ppn$) $\rightarrow$ $^{73}$Zn e$^+\pi^+$. The half-life limit for the invisible tri-proton decay mode of $^{76}$Ge is found to be $1.4\times10^{25}$ yr. Furthermore, we have updated limits for corresponding multi-nucleon decays.
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- 2024
8. Retrieval-Augmented Semantic Parsing: Using Large Language Models to Improve Generalization
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Zhang, Xiao, Meng, Qianru, and Bos, Johan
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Computer Science - Computation and Language - Abstract
Open-domain semantic parsing remains a challenging task, as models often rely on heuristics and struggle to handle unseen concepts. In this paper, we investigate the potential of large language models (LLMs) for this task and introduce Retrieval-Augmented Semantic Parsing (RASP), a simple yet effective approach that integrates external lexical knowledge into the parsing process. Our experiments not only show that LLMs outperform previous encoder-decoder baselines for semantic parsing, but that RASP further enhances their ability to predict unseen concepts, nearly doubling the performance of previous models on out-of-distribution concepts. These findings highlight the promise of leveraging large language models and retrieval mechanisms for robust and open-domain semantic parsing., Comment: Submitted to ARR
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- 2024
9. Developing Functional Thinking: From Concrete to Abstract through an Embodied Design
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Hang Wei, Rogier Bos, and Paul Drijvers
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In addressing the challenge of fostering functional thinking (FT) in secondary school students, our research centered on the question of how an embodied design can enhance FT's different aspects, including input-output, covariation, and correspondence views. Drawing from embodied cognition theory and focusing on an action- and perception-based task design that uses light ray contexts and different function representations, we developed a digital-embodied learning environment, using the nomogram as a central representation. Our pilot study involving four eighth-grade students provided insights into their physical interactions with these modules through a multi-touch digital interface. Analysis of video and audio recordings from the pilots, including students' hand gestures and verbal expressions, was guided by comparing hypothetical learning activities with the actual learning activities. The results show that (1) a concrete light ray context enables students to ground the abstract mathematical function concept; (2) the bimanual coordinating motion tasks, incorporating the covariation aspect of FT, allow students to connect their bodily experience with function properties; and (3) our embodied and dragging tasks support insight in the conversion between nomograms and graphs of functions, encouraging students' correspondence thinking by providing multiple perspectives to understand, reason about, and manipulate the function. In conclusion, our findings suggest the potential of digital-embodied tasks in fostering FT, evident in students' diverse strategies and reasoning.
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- 2024
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10. Evaluating Perceptual Deviations in Video See-Through Head-Mounted Displays while Utilizing Physical Touchscreens
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de Lange, Rudy De-Xin, Bakker, Roemer Martin Bien, and Bos, Tanja Johanna Juliana
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Computer Science - Human-Computer Interaction - Abstract
Extended reality technology has become a useful tool in many applications, but still suffers from visual deviations that can hamper the utility of the technology. This paper discusses the types of persisting visual deviations experienced when observing the natural world through video see-through head-mounted displays. A generalizable method to measure the effect of these deviations on real-world interaction is designed and used in a human-in-the-loop experiment. The experiment compared video see-through sight through an head-mounted display with normal eyesight in a static set-up, focusing on (camera) lens distortions and display deviations. Participants interacted with a real touchscreen, locating the position of flashed markers shortly after disappearance comparing both conditions to check for deviations in position and time. Results show significant larger mean distance errors between the interaction locations and the original marker positions for video see-through compared to normal eyesight. Moreover, errors increase towards the screen periphery. No significant distance error improvement over time was found, however, response times did significantly decrease for both types of sight., Comment: 10 pages. Preprint. A shortened 4-page version of this paper was accepted to the IEEE ISMAR2024 poster track
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- 2024
11. Machine Learning-Powered Data Cleaning for LEGEND
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León, E., Li, A., Schott, M. A. Bahena, Bos, B., Busch, M., Chapman, J. R., Duran, G. L., Gruszko, J., Henning, R., Martin, E. L., and Wilkerson, J. F.
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Physics - Data Analysis, Statistics and Probability ,Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
Neutrinoless double-beta decay ($0\nu\beta\beta$) is a rare nuclear process that, if observed, will provide insight into the nature of neutrinos and help explain the matter-antimatter asymmetry in the universe. The Large Enriched Germanium Experiment for Neutrinoless Double-Beta Decay (LEGEND) will operate in two phases to search for $0\nu\beta\beta$. The first (second) stage will employ 200 (1000) kg of High-Purity Germanium (HPGe) enriched in $^{76}$Ge to achieve a half-life sensitivity of 10$^{27}$ (10$^{28}$) years. In this study, we present a semi-supervised data-driven approach to remove non-physical events captured by HPGe detectors powered by a novel artificial intelligence model. We utilize Affinity Propagation to cluster waveform signals based on their shape and a Support Vector Machine to classify them into different categories. We train, optimize, test our model on data taken from a natural abundance HPGe detector installed in the Full Chain Test experimental stand at the University of North Carolina at Chapel Hill. We demonstrate that our model yields a maximum physics event sacrifice of $0.024 ^{+0.004}_{-0.003} \%$ when performing data cleaning cuts. Our model is being used to accelerate data cleaning development for LEGEND-200., Comment: 11 pages, 13 figures
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- 2024
12. Final Results of the MAJORANA DEMONSTRATOR's Search for Double-Beta Decay of $^{76}$Ge to Excited States of $^{76}$Se
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Blalock, E., Bos, B., Busch, M., Chan, Y. -D., Chapman, J. R., Christofferson, C. D., Chu, P. -H., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Fuad, N., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Massarczyk, R., Meijer, S. J., Oli, T. K., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Schaper, D. C., Schleich, S. J., Tedeschi, D., Varner, R. L., Vasilyev, S., Watkins, S. L., Wilkerson, J. F., Wiseman, C., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment - Abstract
$^{76}$Ge can $\beta\beta$ decay into three possible excited states of $^{76}$Se, with the emission of two or, if the neutrino is Majorana, zero neutrinos. None of these six transitions have yet been observed. The MAJORANA DEMONSTRATOR was designed to study $\beta\beta$ decay of $^{76}$Ge using a low background array of high purity germanium detectors. With 98.2 kg-y of isotopic exposure, the DEMONSTRATOR sets the strongest half-life limits to date for all six transition modes. For $2\nu\beta\beta$ to the $0^+_1$ state of $^{76}$Se, this search has begun to probe for the first time half-life values predicted using modern many-body nuclear theory techniques, setting a limit of $T_{1/2}>1.5\times10^{24}$ y (90% CL)., Comment: 8 pages, 3 figures
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- 2024
13. Using the Data-Based Individualization Framework in Math Intervention
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Sarah R. Powell, Samantha E. Bos, Sarah G. King, Leanne Ketterlin-Geller, and Erica S. Lembke
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Data-based individualization (DBI) is a framework that allows educators to make timely and informed decisions about student progress in academics or behavior. In this article, we focus on the DBI framework as applied to math intervention within a tiered support model for students experiencing math difficulty. We review how DBI starts with an instructional platform paired with progress monitoring. Then, we discuss decision making within a DBI framework and highlight how diagnostic data informs instructional adaptations. Finally, we emphasize the on-going use of DBI to determine the best set of instructional practices in math for each student.
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- 2024
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14. Reciprocal Self-Disclosure Makes Children Feel More Loved by Their Parents in the Moment: A Proof-of-Concept Experiment
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Eddie Brummelman, Peter A. Bos, Eva de Boer, Barbara Nevicka, and Constantine Sedikides
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Feeling loved by one's parents is critical for children's health and well-being. How can such feelings be fostered? A vital feature of loving interactions is reciprocal self-disclosure, where individuals disclose intimate information about themselves. In a proof-of-concept experiment, we examined whether encouraging reciprocal self-disclosure in parent-child dyads would make children feel more loved during the conversation. Participants were 218 children (ages 8-13, 50% girls, 94% Dutch) and one of their parents (ages 28-56, 62% women, 90% Dutch). Parent-child dyads received a list of 14 questions and took turns asking them each other for 9 min. Dyads were assigned randomly to engage in self-disclosure (questions invoking escalated intimacy) or small talk (questions invoking minimal intimacy). Before and after, children reported how loved they felt by their parent during the conversation. Self-disclosure made children feel more loved during the conversation than did small talk. Compared to small talk, self-disclosure did not instigate conversations that were lengthier or more positive; rather, it instigated conversations that were more emotionally charged (reflecting anger, anxiety, and sadness), social (discussing family and friends), reflective (creating insight), and meaningful (addressing deeply personal topics, including the passing of loved ones). The dyad's gender composition did not significantly moderate these effects. Our research suggests that reciprocal self-disclosure can make children feel more loved in the moment, uncovers linguistic signatures of reciprocal self-disclosure, and offers developmental scientists a tool to examine causal effects of reciprocal self-disclosure in parent-child dyads. Future work should examine long-term effects in everyday parent-child interactions.
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- 2024
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15. Reifying Actions into Artifacts: Process-Object Duality from an Embodied Perspective on Mathematics Learning
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Anna Shvarts, Rogier Bos, Michiel Doorman, and Paul Drijvers
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Grasping mathematical objects as related to processes is often considered critical for mathematics understanding. Yet, the ontology of mathematical objects remains under debate. In this paper, we theoretically oppose internalist approaches that claim mental entities as the endpoints of process-object transitions and externalist approaches that stress mathematical artifacts--such as physical manipulatives and formulas--as constituting mathematical objects. We search for a view on process-object duality that overcomes the dualism of mind and body. One such approach is commognition that describes mathematical objects as discursive entities. This paper expands the nature of mathematical objects beyond discourse and highlights the role of learners' interaction with the environment by adopting ecological onto-epistemology. We develop a functional dynamic systems perspective on process-object duality in mathematics learning emphasizing embodied actions and the re-invention of artifacts' affordances. As a main result, we reconsider process?-object duality as a reification of repetitive actions into a cultural artifact that consists of two steps: (1) forming a new sensory-motor coordination that brings new perception to the fore and (2) crystallizing a new artifact in a mathematical environment that captures this new perception. An empirical example from research on embodied action-based design for trigonometry illustrates our theoretical ideas.
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- 2024
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16. An assay-based background projection for the MAJORANA DEMONSTRATOR using Monte Carlo Uncertainty Propagation
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Caldwell, T. S., Chan, Y. -D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Fuad, N., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., López-Castaño, J. M., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Schleich, S. J., Tedeschi, D., Varner, R. L., Vasilyev, S., Watkins, S. L., Wilkerson, J. F., Wiseman, C., Xu, W., and Yu, C. -H.
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Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
The background index is an important quantity which is used in projecting and calculating the half-life sensitivity of neutrinoless double-beta decay ($0\nu\beta\beta$) experiments. A novel analysis framework is presented to calculate the background index using the specific activities, masses and simulated efficiencies of an experiment's components as distributions. This Bayesian framework includes a unified approach to combine specific activities from assay. Monte Carlo uncertainty propagation is used to build a background index distribution from the specific activity, mass and efficiency distributions. This analysis method is applied to the MAJORANA DEMONSTRATOR, which deployed arrays of high-purity Ge detectors enriched in $^{76}$Ge to search for $0\nu\beta\beta$. The framework projects a mean background index of $\left[8.95 \pm 0.36\right] \times 10^{-4}$cts/(keV kg yr) from $^{232}$Th and $^{238}$U in the DEMONSTRATOR's components., Comment: 9 pages, 3 figures
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- 2024
17. Adversarial Circuit Evaluation
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de Bos, Niels uit and Garriga-Alonso, Adrià
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Computer Science - Machine Learning - Abstract
Circuits are supposed to accurately describe how a neural network performs a specific task, but do they really? We evaluate three circuits found in the literature (IOI, greater-than, and docstring) in an adversarial manner, considering inputs where the circuit's behavior maximally diverges from the full model. Concretely, we measure the KL divergence between the full model's output and the circuit's output, calculated through resample ablation, and we analyze the worst-performing inputs. Our results show that the circuits for the IOI and docstring tasks fail to behave similarly to the full model even on completely benign inputs from the original task, indicating that more robust circuits are needed for safety-critical applications., Comment: 19 pages, 10 figures
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- 2024
18. In-lab and On-sky Closed-loop Results of Adaptive Secondary Mirrors with TNO's Hybrid Variable Reluctance Actuators
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Zhang, Ruihan, Baeten, Max, Chun, Mark R., Lee, Ellen, Connelley, Michael, Lai, Olivier, Kuiper, Stefan, Ryan, Alan, Bos, Arjo, Bowens-Rubin, Rachel, and Hinz, Philip M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We performed closed-loop lab testing of large-format deformable mirrors (DMs) with hybrid variable reluctance actuators. TNO has been developing the hybrid variable reluctance actuators in support for a new generation of adaptive secondary mirrors (ASMs), which aim to be more robust and reliable. Compared to the voice coil actuators, this new actuator technology has a higher current to force efficiency, and thus can support DMs with thicker facesheets. Before putting this new technology on-sky, it is necessary to understand how to control it and how it behaves in closed-loop. We performed closed-loop tests with the Shack-Hartmann wavefront sensor with three large-format deformable mirrors that use the TNO actuators: DM3, FLASH, and IRTF-ASM-1 ASM. The wavefront sensor and the real-time control systems were developed for the NASA Infrared Telescope Facility (IRTF) and the UH 2.2-meter telescope ASMs. We tested IRTF-ASM-1 on-sky and proved that it meets all of our performance requirements. This work presents our lab setup for the experiments, the techniques we have employed to drive these new ASMs, the results of our closed-loop lab tests for FLASH and IRTF-ASM-1, and the on-sky closed-loop results of IRTF-ASM-1 ASM., Comment: 15 pages, 12 figures, SPIE Astronomical Telescopes + Instrumentation 2024
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- 2024
19. First laboratory and on-sky results of an adaptive secondary mirror with TNO-style actuators on the NASA Infrared Telescope Facility
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Lee, Ellen, Chun, Mark, Lai, Olivier, Zhang, Ruihan, Baeten, Max, Bos, Arjo, Kidron, Matias, Kamphues, Fred, Kuiper, Stefan, Jonker, Wouter, Connelley, Michael, Rayner, John, Ryan, Alan, Hinz, Philip, Bowens-Rubin, Rachel, Lockhart, Charles, and Kelii, Michael
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We are developing an adaptive secondary mirror (ASM) that uses a new actuator technology created by the Netherlands Organization for Applied Scientific Research (TNO). The TNO hybrid variable reluctance actuators have more than an order of magnitude better efficiency over the traditional voice coil actuators that have been used on existing ASMs and show potential for improving the long-term robustness and reliability of ASMs. To demonstrate the performance, operations, and serviceability of TNO's actuators in an observatory, we have developed a 36-actuator prototype ASM for the NASA Infrared Telescope Facility (IRTF) called IRTF-ASM-1. IRTF-ASM-1 provides the first on-sky demonstration of this approach and will help us evaluate the long-term performance and use of this technology in an astronomical facility environment. We present calibration and performance results with the ASM in a Meniscus Hindle Sphere lens setup as well as preliminary on-sky results on IRTF. IRTF-ASM-1 achieved stable closed-loop performance on-sky with H-band Strehl ratios of 35-40% in long-exposure images under a variety of seeing conditions., Comment: 15 pages, 12 figures, SPIE Astronomical Telescopes + Instrumentation: Adaptive Optics Systems IX
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- 2024
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20. Scope-enhanced Compositional Semantic Parsing for DRT
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Yang, Xiulin, Groschwitz, Jonas, Koller, Alexander, and Bos, Johan
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Computer Science - Computation and Language - Abstract
Discourse Representation Theory (DRT) distinguishes itself from other semantic representation frameworks by its ability to model complex semantic and discourse phenomena through structural nesting and variable binding. While seq2seq models hold the state of the art on DRT parsing, their accuracy degrades with the complexity of the sentence, and they sometimes struggle to produce well-formed DRT representations. We introduce the AMS parser, a compositional, neurosymbolic semantic parser for DRT. It rests on a novel mechanism for predicting quantifier scope. We show that the AMS parser reliably produces well-formed outputs and performs well on DRT parsing, especially on complex sentences.
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- 2024
21. Micro-power spoken keyword spotting on Xylo Audio 2
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Bos, Hannah and Muir, Dylan R.
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Computer Science - Neural and Evolutionary Computing - Abstract
For many years, designs for "Neuromorphic" or brain-like processors have been motivated by achieving extreme energy efficiency, compared with von-Neumann and tensor processor devices. As part of their design language, Neuromorphic processors take advantage of weight, parameter, state and activity sparsity. In the extreme case, neural networks based on these principles mimic the sparse activity oof biological nervous systems, in ``Spiking Neural Networks'' (SNNs). Few benchmarks are available for Neuromorphic processors, that have been implemented for a range of Neuromorphic and non-Neuromorphic platforms, which can therefore demonstrate the energy benefits of Neuromorphic processor designs. Here we describes the implementation of a spoken audio keyword-spotting (KWS) benchmark "Aloha" on the Xylo Audio 2 (SYNS61210) Neuromorphic processor device. We obtained high deployed quantized task accuracy, (95%), exceeding the benchmark task accuracy. We measured real continuous power of the deployed application on Xylo. We obtained best-in-class dynamic inference power ($291\mu$W) and best-in-class inference efficiency ($6.6\mu$J / Inf). Xylo sets a new minimum power for the Aloha KWS benchmark, and highlights the extreme energy efficiency achievable with Neuromorphic processor designs. Our results show that Neuromorphic designs are well-suited for real-time near- and in-sensor processing on edge devices.
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- 2024
22. Explainability and Hate Speech: Structured Explanations Make Social Media Moderators Faster
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Calabrese, Agostina, Neves, Leonardo, Shah, Neil, Bos, Maarten W., Ross, Björn, Lapata, Mirella, and Barbieri, Francesco
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Computer Science - Computation and Language - Abstract
Content moderators play a key role in keeping the conversation on social media healthy. While the high volume of content they need to judge represents a bottleneck to the moderation pipeline, no studies have explored how models could support them to make faster decisions. There is, by now, a vast body of research into detecting hate speech, sometimes explicitly motivated by a desire to help improve content moderation, but published research using real content moderators is scarce. In this work we investigate the effect of explanations on the speed of real-world moderators. Our experiments show that while generic explanations do not affect their speed and are often ignored, structured explanations lower moderators' decision making time by 7.4%., Comment: 11 pages, 14 figures, to be published at ACL 2024
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- 2024
23. Long-term health-related quality of life among adolescent and young adult breast cancer survivors
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Vrancken Peeters, Noelle J. M. C., Kerklaan, Roos, Vlooswijk, Carla, Bijlsma, Rhodé M., Kaal, Suzanne E. J., Tromp, Jacqueline M., Bos, Monique E. M. M., van der Hulle, Tom, de Boer, Maaike, Nuver, Janine, Kouwenhoven, Mathilde C. M., van der Graaf, Winette T. A., and Husson, Olga
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- 2025
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24. Earliest modern human genomes constrain timing of Neanderthal admixture
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Sümer, Arev P., Rougier, Hélène, Villalba-Mouco, Vanessa, Huang, Yilei, Iasi, Leonardo N. M., Essel, Elena, Bossoms Mesa, Alba, Furtwaengler, Anja, Peyrégne, Stéphane, de Filippo, Cesare, Rohrlach, Adam B., Pierini, Federica, Mafessoni, Fabrizio, Fewlass, Helen, Zavala, Elena I., Mylopotamitaki, Dorothea, Bianco, Raffaela A., Schmidt, Anna, Zorn, Julia, Nickel, Birgit, Patova, Anna, Posth, Cosimo, Smith, Geoff M., Ruebens, Karen, Sinet-Mathiot, Virginie, Stoessel, Alexander, Dietl, Holger, Orschiedt, Jörg, Kelso, Janet, Zeberg, Hugo, Bos, Kirsten I., Welker, Frido, Weiss, Marcel, McPherron, Shannon P., Schüler, Tim, Hublin, Jean-Jacques, Velemínský, Petr, Brůžek, Jaroslav, Peter, Benjamin M., Meyer, Matthias, Meller, Harald, Ringbauer, Harald, Hajdinjak, Mateja, Prüfer, Kay, and Krause, Johannes
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- 2025
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25. A generic seismic risk protocol for energy production sites
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Grigoratos, Iason, Schultz, Ryan, van Ginkel, Janneke, Gunatilake, Thanushika, Wiemer, Stefan, van der Wal, Jorien L.N., and Muntendam-Bos, Annemarie G.
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- 2025
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26. Phase separation and ageing of glycine-rich protein from tick adhesive
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Ganar, Ketan A., Nandy, Manali, Turbina, Polina, Chen, Chang, Suylen, Dennis, Nihoul, Elisa, Pascoe, Emily Louise, van der Beelen, Stan, Plaum, Maarten, van den Bos, Leendert, Koenraadt, Constantianus J. M., Dijkgraaf, Ingrid, and Deshpande, Siddharth
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- 2025
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27. Validation of a commercially available CAD-system for lung nodule detection and characterization using CT-scans
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Paramasamy, Jasika, Mandal, Souvik, Blomjous, Maurits, Mulders, Ties, Bos, Daniel, Aerts, Joachim G. J. V., Vanapalli, Prakash, Challa, Vikash, Sathyamurthy, Saigopal, Devi, Ranjana, Jain, Ritvik, and Visser, Jacob J.
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- 2025
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28. Self-Monitoring and Self-Efficacy in Patients with Chronic Kidney Disease During Low-Sodium Diet Self-Management Interventions: Secondary Analysis of the ESMO and SUBLIME Trials
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Hoekstra, Tiny, Dam, Manouk, Klaassen, Gerald, Bos, Willem Jan W., van der Boog, Paul J. M., Vogt, Liffert, van Jaarsveld, Brigit, van Dijk, Sandra, Navis, Gerjan, and Meuleman, Yvette
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- 2025
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29. Systematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe
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Amat-Fernandez, Clara, Garin, Olatz, Luer-Aguila, Ricardo, Pardo, Yolanda, Briseño, Renata, Lizano-Barrantes, Catalina, Rojas-Concha, Leslye, S.Y. Thong, Melissa, Apolone, Giovanni, Brunelli, Cinzia, Caraceni, Augusto, Couespel, Norbert, Bos, Nanne, Groenvold, Mogens, Kaasa, Stein, Ciliberto, Gennaro, Lombardo, Claudio, Pietrobon, Ricardo, Pravettoni, Gabriella, Sirven, Aude, Vachon, Hugo, Gilbert, Alexandra, Velikova, Galina, and Ferrer, Montse
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- 2025
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30. Fine resolution satellite sea surface temperatures capture the conditions experienced by corals at monthly but not daily timescales
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Bos, Jaelyn T. and Pinsky, Malin L.
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- 2025
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31. Zorgrobot als collega: Zorgrobot als collega
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Bos, Christel
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- 2025
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32. Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold
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Lindland, Elisabeth S., Røvang, Martin S., Solheim, Anne Marit, Andreassen, Silje, Skarstein, Ingerid, Dareez, Nazeer, MacIntosh, Bradley J., Eikeland, Randi, Ljøstad, Unn, Mygland, Åse, Bos, Steffan D., Ulvestad, Elling, Reiso, Harald, Lorentzen, Åslaug R., Harbo, Hanne F., Bjørnerud, Atle, and Beyer, Mona K.
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- 2025
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33. Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment
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Adella, Anastasia, Gommers, Lisanne M. M., Bos, Caro, Leermakers, Pieter A., de Baaij, Jeroen H. F., and Hoenderop, Joost G. J.
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- 2025
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34. Mental Health Disparities Between Both-, Other- and Same-Sex Attracted Adolescents: The Role of Bullying Victimization, Gender and Age
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Cup, Vera H., Bos, Henny M. W., Stevens, Gonneke W. J. M., and de Looze, Margreet E.
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- 2024
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35. Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies
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Schalbroeck, Rik, van Hooijdonk, Carmen F. M., Bos, Daniëlle P. A., Booij, Jan, and Selten, Jean-Paul
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- 2024
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36. The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors
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van Holstein, Yara, Mooijaart, Simon P., van Oevelen, Mathijs, van Deudekom, Floor J., Vojinovic, Dina, Bizzarri, Daniele, van den Akker, Erik B., Noordam, Raymond, Deelen, Joris, van Heemst, Diana, de Glas, Nienke A., Holterhues, Cynthia, Labots, Geert, van den Bos, Frederiek, Beekman, Marian, Slagboom, P. Eline, van Munster, Barbara C., Portielje, Johanneke E. A., and Trompet, Stella
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- 2024
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37. Lesions hyper- to isointense to surrounding liver in the hepatobiliary phase of gadoxetic acid-enhanced MRI
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Furumaya, Alicia, Willemssen, François E. J. A., Miclea, Razvan L., Haring, Martijn P. D., de Haas, Robbert J., Feshtali, Shirin, Vanhooymissen, Inge J. S., Bos, Daniel, de Man, Robert A., Ijzermans, Jan N. M., Erdmann, Joris I., Verheij, Joanne, Doukas, Michail C., van Delden, Otto M., and Thomeer, Maarten G. J.
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- 2024
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38. Pre-Conception Interventions for Subfertile Couples Undergoing Assisted Reproductive Technology Treatment: Modeling Analysis
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Steegers-Theunissen, Régine, Hoek, Annemieke, Groen, Henk, Bos, Annelies, van den Dool, Grada, Schoonenberg, Marieke, Smeenk, Jesper, Creutzberg, Eva, Vecht, Loes, Starmans, Luc, and Laven, Joop
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Information technology ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundApproximately 1 in 7 couples experience subfertility, many of whom have lifestyles that negatively affect fertility, such as poor nutrition, low physical activity, obesity, smoking, or alcohol consumption. Reducing lifestyle risk factors prior to pregnancy or assisted reproductive technology treatment contributes to the improvement of reproductive health, but cost-implications are unknown. ObjectiveThe goal of this study was to evaluate reproductive, maternal pregnancy, and birth outcomes, as well as the costs of pre-conception lifestyle intervention programs in subfertile couples and obese women undergoing assisted reproductive technology. MethodsUsing a hypothetical model based on quantitative parameters from published literature and expert opinion, we evaluated the following lifestyle intervention programs: (1) Smarter Pregnancy, an online tool; (2) LIFEstyle, which provides outpatient support for obese women; (3) concurrent use of both Smarter Pregnancy and LIFEstyle for obese women; (4) smoking cessation in men; and (5) a mindfulness mental health support program using group therapy sessions. The model population was based on data from the Netherlands. ResultsAll model-based analyses of the lifestyle interventions showed a reduction in the number of in vitro fertilization, intracytoplasmic sperm injection, or intrauterine insemination treatments required to achieve pregnancy and successful birth for couples in the Netherlands. Smarter Pregnancy was modeled to have the largest increase in spontaneous pregnancy rate (13.0%) and the largest absolute reduction in potential assisted reproductive technology treatments. Among obese subfertile women, LIFEstyle was modeled to show a reduction in the occurrence of gestational diabetes, maternal hypertensive pregnancy complications, and preterm births by 4.4%, 3.8%, and 3.0%, respectively, per couple. Modeled cost savings per couple per year were €41 (US $48.66), €360 (US $427.23), €513 (US $608.80), €586 (US $695.43), and €1163 (US $1380.18) for smoking cessation, mindfulness, Smarter Pregnancy, combined Smarter Pregnancy AND LIFEstyle, and LIFEstyle interventions, respectively. ConclusionsAlthough we modeled the potential impact on reproductive outcomes and costs of fertility treatment rather than collecting real-world data, our model suggests that of the lifestyle interventions for encouraging healthier behaviors, all are likely to be cost effective and appear to have positive effects on reproductive, maternal pregnancy, and birth outcomes. Further real-world data are required to determine the cost-effectiveness of pre-conception lifestyle interventions, including mobile apps and web-based tools that help improve lifestyle, and their effects on reproductive health. We believe that further implementation of the lifestyle app Smarter Pregnancy designed for subfertile couples seeking assistance to become pregnant is likely to be cost-effective and would allow reproductive health outcomes to be collected.
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- 2020
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39. Purifying Adversarial Examples Using an Autoencoder
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van Weezel, Thijs, van Ree, Famke, Bos, Tychon, Bastiaanssen, Patrick, Hess, Sibylle, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Pedreschi, Dino, editor, Monreale, Anna, editor, Guidotti, Riccardo, editor, Pellungrini, Roberto, editor, and Naretto, Francesca, editor
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- 2025
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40. VeyMont: Choreography-Based Generation of Correct Concurrent Programs with Shared Memory
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Rubbens, Robert, Bos, Petra van den, Huisman, Marieke, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kosmatov, Nikolai, editor, and Kovács, Laura, editor
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- 2025
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41. Equations for the overlaps of a SIC
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Bos, Len and Waldron, Shayne
- Subjects
Computer Science - Information Theory ,20F70, 81P15, 81Q10, 81R05 - Abstract
We give a holomorphic quartic polynomial in the overlap variables whose zeros on the torus are precisely the Weyl-Heisenberg SICs (symmetric informationally complete positive operator valued measures). By way of comparison, all the other known systems of equations that determine a Weyl-Heisenberg SIC involve variables and their complex conjugates. We also give a related interesting result about the powers of the projective Fourier transform of the group G = Z d x Z d ., Comment: 19 Pages
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- 2024
42. Neural Semantic Parsing with Extremely Rich Symbolic Meaning Representations
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Zhang, Xiao, Bouma, Gosse, and Bos, Johan
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Computer Science - Computation and Language - Abstract
Current open-domain neural semantics parsers show impressive performance. However, closer inspection of the symbolic meaning representations they produce reveals significant weaknesses: sometimes they tend to merely copy character sequences from the source text to form symbolic concepts, defaulting to the most frequent word sense based in the training distribution. By leveraging the hierarchical structure of a lexical ontology, we introduce a novel compositional symbolic representation for concepts based on their position in the taxonomical hierarchy. This representation provides richer semantic information and enhances interpretability. We introduce a neural "taxonomical" semantic parser to utilize this new representation system of predicates, and compare it with a standard neural semantic parser trained on the traditional meaning representation format, employing a novel challenge set and evaluation metric for evaluation. Our experimental findings demonstrate that the taxonomical model, trained on much richer and complex meaning representations, is slightly subordinate in performance to the traditional model using the standard metrics for evaluation, but outperforms it when dealing with out-of-vocabulary concepts. This finding is encouraging for research in computational semantics that aims to combine data-driven distributional meanings with knowledge-based symbolic representations., Comment: This manuscript has been accepted by Computational Linguistics journal on 2024-09-07
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- 2024
43. PMB5: Gaining More Insight into Neural Semantic Parsing with Challenging Benchmarks
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Zhang, Xiao, Wang, Chunliu, van Noord, Rik, and Bos, Johan
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Computer Science - Computation and Language - Abstract
The Parallel Meaning Bank (PMB) serves as a corpus for semantic processing with a focus on semantic parsing and text generation. Currently, we witness an excellent performance of neural parsers and generators on the PMB. This might suggest that such semantic processing tasks have by and large been solved. We argue that this is not the case and that performance scores from the past on the PMB are inflated by non-optimal data splits and test sets that are too easy. In response, we introduce several changes. First, instead of the prior random split, we propose a more systematic splitting approach to improve the reliability of the standard test data. Second, except for the standard test set, we also propose two challenge sets: one with longer texts including discourse structure, and one that addresses compositional generalization. We evaluate five neural models for semantic parsing and meaning-to-text generation. Our results show that model performance declines (in some cases dramatically) on the challenge sets, revealing the limitations of neural models when confronting such challenges.
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- 2024
44. USE: Dynamic User Modeling with Stateful Sequence Models
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Zhou, Zhihan, Fang, Qixiang, Neves, Leonardo, Barbieri, Francesco, Liu, Yozen, Liu, Han, Bos, Maarten W., and Dotsch, Ron
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Computer Science - Social and Information Networks ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Human-Computer Interaction ,Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
User embeddings play a crucial role in user engagement forecasting and personalized services. Recent advances in sequence modeling have sparked interest in learning user embeddings from behavioral data. Yet behavior-based user embedding learning faces the unique challenge of dynamic user modeling. As users continuously interact with the apps, user embeddings should be periodically updated to account for users' recent and long-term behavior patterns. Existing methods highly rely on stateless sequence models that lack memory of historical behavior. They have to either discard historical data and use only the most recent data or reprocess the old and new data jointly. Both cases incur substantial computational overhead. To address this limitation, we introduce User Stateful Embedding (USE). USE generates user embeddings and reflects users' evolving behaviors without the need for exhaustive reprocessing by storing previous model states and revisiting them in the future. Furthermore, we introduce a novel training objective named future W-behavior prediction to transcend the limitations of next-token prediction by forecasting a broader horizon of upcoming user behaviors. By combining it with the Same User Prediction, a contrastive learning-based objective that predicts whether different segments of behavior sequences belong to the same user, we further improve the embeddings' distinctiveness and representativeness. We conducted experiments on 8 downstream tasks using Snapchat users' behavioral logs in both static (i.e., fixed user behavior sequences) and dynamic (i.e., periodically updated user behavior sequences) settings. We demonstrate USE's superior performance over established baselines. The results underscore USE's effectiveness and efficiency in integrating historical and recent user behavior sequences into user embeddings in dynamic user modeling.
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- 2024
45. On minimizing cyclists' ascent times
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Bos, Len, Slawinski, Michael A., Slawinski, Raphaël A., and Stanoev, Theodore
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Physics - Classical Physics ,Physics - Popular Physics - Abstract
We prove that, given an average power, the ascent time is minimized if a cyclist maintains a constant ground speed regardless of the slope. Herein, minimizing the time is equivalent to maximizing -- for a given uphill -- the corresponding mean ascent velocity (VAM: velocit\`a ascensionale media), which is a common training metric. We illustrate the proof with numerical examples, and show that, in general, maintaining a constant instantaneous power results in longer ascent times; both strategies result in the same time if the slope is constant. To remain within the athlete's capacity, we examine the effect of complementing the average-power constraint with a maximum-power constraint. Even with this additional constraint, the ascent time is the shortest with a modified constant-speed -- not constant-power -- strategy; as expected, both strategies result in the same time if the maximum and average powers are equal to one another. Given standard available information -- including level of fitness, quantified by the power output, and ascent profile -- our results allow to formulate reliable and convenient strategies of uphill timetrials.
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- 2024
46. 3. Communicating Delegitimisation : Political Information and Challenges to Democracy
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Hameleers, Michael, primary, Gravesteijn, Emily, additional, Bos, Linda, additional, and Nai, Alessandro, additional
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- 2024
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47. 4. Disenchantment with Political Information : Attitudes, Processes, and Effects
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Nai, Alessandro, primary, Vermeer, Susan, additional, Bos, Linda, additional, and Hameleers, Michael, additional
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- 2024
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48. Wanting to matter and learning to care: A neurodevelopmental window of opportunity for (Pro) social learning?
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Dahl, Ronald, Armstrong-Carter, Emma, and van den Bos, Wouter
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Adolescent development ,Hypothalamus ,Mattering ,Prosocial development ,Pubertal maturation ,Salience network - Abstract
Wanting to matter-to feel socially recognized, appreciated, and capable of actions that benefit others-represents a fundamental motivation in human development. The motivational salience of mattering appears to increase in adolescence. Evidence suggests this is related to pubertal increases in the incentive salience for gaining social value and personal agency. This can provide a useful heuristic for understanding motivational proclivities (i.e. wanting to matter) that influence action-outcome learning as young adolescents are exploring and learning how to navigate increasingly complex social and relational environments. Adolescence also brings new capacities, motives, and opportunities for learning to care about and contribute to the benefit of others. Together, these create a window of opportunity: a sensitive period for learning to gain salient feelings of mattering through caring prosocial actions and valued societal contributions. Successfully discovering ways of mattering by doing things that matter to others may contribute to formative socio-emotional learning about self/other. Advances in understanding these social and relational learning processes and their neurodevelopmental underpinnings can inform strategies to improve developmental trajectories of social competence and wellbeing among adolescents growing up in a rapidly changing and increasingly techno-centric world.
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- 2024
49. Search for charge non-conservation and Pauli exclusion principle violation with the Majorana Demonstrator
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Lannen V, RT, Lannen, IE, Li, A, Lopez-Castano, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Oli, TK, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Schaper, DC, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Physical Sciences ,Mathematical Sciences ,Fluids & Plasmas ,Mathematical sciences ,Physical sciences - Abstract
Charge conservation and the Pauli exclusion principle result from fundamental symmetries in the standard model of particle physics, and are typically taken as axiomatic. High-precision tests for small violations of these symmetries could point to new physics. Here we consider three models for violation of these processes, which would produce detectable ionization in the high-purity germanium detectors of the Majorana Demonstrator experiment. Using a 37.5 kg yr exposure, we report a lower limit on the electron mean lifetime, improving the previous best limit for the e→νeνe¯νe decay channel by more than an order of magnitude. We also present searches for two types of violation of the Pauli exclusion principle, setting limits on the probability of an electron to be found in a symmetric quantum state.
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- 2024
50. Neurodevelopment in preschool children exposed and unexposed to Zika virus in utero in Nicaragua: a prospective cohort study.
- Author
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Max, Ryan, Toval-Ruiz, Christian, Becker-Dreps, Sylvia, Gajewski, Anna, Martinez, Evelin, Cross, Kaitlyn, Blette, Bryan, Ortega, Oscar, Collado, Damaris, Zepeda, Omar, Familiar, Itziar, Boivin, Michael, Chavarria, Meylin, Meléndez, María, Mercado, Juan, de Silva, Aravinda, Collins, Matthew, Westreich, Daniel, Bos, Sandra, Harris, Eva, Balmaseda, Angel, Gower, Emily, Bowman, Natalie, Stringer, Elizabeth, and Bucardo, Filemón
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Humans ,Nicaragua ,Zika Virus Infection ,Female ,Prospective Studies ,Child ,Preschool ,Pregnancy ,Male ,Prenatal Exposure Delayed Effects ,Infant ,Pregnancy Complications ,Infectious ,Child Development ,Zika Virus ,Adult ,Neurodevelopmental Disorders - Abstract
BACKGROUND: Data on long-term neurodevelopmental outcomes of normocephalic children (born with normal head circumference) exposed to Zika virus in utero are scarce. We aimed to compare neurodevelopmental outcomes in normocephalic children up to age 48 months with and without Zika virus exposure in utero. METHODS: In this prospective cohort study, we included infants from two cohorts of normocephalic children born in León and Managua, Nicaragua during the 2016 Zika epidemic. In León, all women pregnant during the two enrolment periods were eligible. In Managua, mother-child pairs were included from three districts in the municipality of Managua: all women who became pregnant before June 15, 2016, and had a due date of Sept 15, 2016 or later were eligible. Infants were serologically classified as Zika virus-exposed or Zika virus-unexposed in utero and were followed up prospectively until age 48 months. At 36 months and 48 months of age, the Mullen Scales of Early Learning (MSEL) assessment was administered. Primary outcomes were MSEL early learning composite (ELC) scores at 30-48 months in León and 36-48 months in Managua. We used an inverse probability weighting generalised estimating equations model to assess the effect of Zika virus exposure on individual MSEL cognitive domain scores and ELC scores, adjusted for maternal education and age, poverty status, and infant sex. FINDINGS: The initial enrolment period for the León cohort was between Jan 31 and April 5, 2017 and the second was between Aug 30, 2017, and Feb 22, 2018. The enrolment period for the Managua cohort was between Oct 24, 2019, and May 5, 2020. 478 mothers (482 infants) from the León cohort and 615 mothers (609 infants) from the Managua cohort were enrolled, of whom 622 children (303 from the León cohort; 319 from the Managua cohort) were included in the final analysis; four children had microcephaly at birth and thus were excluded from analyses, two from each cohort. 33 (11%) of 303 children enrolled in León and 219 (69%) of 319 children enrolled in Managua were exposed to Zika virus in utero. In both cohorts, no significant differences were identified in adjusted mean ELC scores between Zika virus-exposed and unexposed infants at 36 months (between-group difference 1·2 points [95% CI -4·2 to 6·5] in the León cohort; 2·8 [-2·4 to 8·1] in the Managua cohort) or at 48 months (-0·9 [-10·8 to 8·8] in the León cohort; 0·1 [-5·1 to 5·2] in the Managua cohort). No differences in ELC scores between Zika virus-exposed and unexposed infants exceeded 6 points at any time between 30 months and 48 months in León or between 36 months and 48 months in Managua, which was considered clinically significant in other settings. INTERPRETATION: We found no significant differences in neurodevelopmental scores between normocephalic children with in-utero Zika virus exposure and Zika virus-unexposed children at age 36 months or 48 months. These findings are promising, supporting typical neurodevelopment in Zika virus-exposed normocephalic children, although additional follow-up and research is warranted. FUNDING: National Institute of Child Health and Development, National Institute of Allergy and Infectious Diseases, and Fogarty International Center. TRANSLATION: For the Spanish translation of the abstract see Supplementary Materials section.
- Published
- 2024
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