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1,329 results on '"Bosco, Domenico"'

9. Feasibility and efficacy of combined pancreatic islet-lung transplantation in cystic fibrosis-related diabetes–PIM study: A multicenter phase 1–2 trial

Author

Rakotoarisoa, Luc, Wagner, Clothilde, Munch, Marion, Renaud Picard, Benjamin, Grenet, Dominique, Olland, Anne, Greget, Michel, Enescu, Iulian, Bouilloud, Florence, Bonnette, Pierre, Guth, Axel, Bosco, Domenico, Mercier, Catherine, Rabilloud, Muriel, Berney, Thierry, Yves Benhamou, Pierre, Massard, Gilbert, Camilo, Coralie, Colin, Cyrille, Arnold, Cécile, Kessler, Romain, and Kessler, Laurence

Published
2022
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10. Coma

Author

Consoli, Domenico, Galati, Franco, Consoli, Arturo, Bosco, Domenico, Micieli, Giuseppe, Serrati, Carlo, Toni, Danilo, Cavallini, Anna, Micieli, Giuseppe, editor, Cavallini, Anna, editor, Ricci, Stefano, editor, Consoli, Domenico, editor, and Edlow, Jonathan A., editor

Published
2021
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12. Ten-year outcomes of islet transplantation in patients with type 1 diabetes: Data from the Swiss-French GRAGIL network

Author

Lablanche, Sandrine, Borot, Sophie, Wojtusciszyn, Anne, Skaare, Kristina, Penfornis, Alfred, Malvezzi, Paolo, Badet, Lionel, Thivolet, Charles, Morelon, Emmanuel, Buron, Fanny, Renard, Eric, Tauveron, Igor, Villard, Oriane, Munch, Marion, Sommacal, Salomé, Clouaire, Léa, Jacquet, Morgane, Gonsaud, Laura, Camillo-Brault, Coralie, Colin, Cyrille, Bosson, Jean-Luc, Bosco, Domenico, Berney, Thierry, Kessler, Laurence, and Benhamou, Pierre-Yves

Published
2021
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14. Impact of ischemia time on islet isolation success and posttransplantation outcomes: A retrospective study of 452 pancreas isolations

Author

Wassmer, Charles-Henri, Perrier, Quentin, Combescure, Christophe, Pernin, Nadine, Parnaud, Géraldine, Cottet-Dumoulin, David, Brioudes, Estelle, Bellofatto, Kevin, Lebreton, Fanny, Berishvili, Ekaterine, Lablanche, Sandrine, Kessler, Laurence, Wojtusciszyn, Anne, Buron, Fanny, Borot, Sophie, Bosco, Domenico, Berney, Thierry, and Lavallard, Vanessa

Published
2021
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15. Spittlebugs as vectors of Xylella fastidiosa in olive orchards in Italy

Author

Cornara, Daniele, Saponari, Maria, Zeilinger, Adam R, de Stradis, Angelo, Boscia, Donato, Loconsole, Giuliana, Bosco, Domenico, Martelli, Giovanni P, Almeida, Rodrigo PP, and Porcelli, Francesco

Subjects
Plant Biology, Biological Sciences, Ecology, Emerging diseases, Plant pathogenic bacteria, Auchenorryncha, Aphrophoridae, Zoology, Entomology, Forestry
Abstract

The recent introduction of Xylella fastidiosa in Europe and its involvement in the Olive Quick Decline Syndrome (OQDS) in Apulia (Salento, Lecce district, South Italy) led us to investigate the biology and transmission ability of the meadow spittlebug, Philaenus spumarius, which was recently demonstrated to transmit X. fastidiosa to periwinkle plants. Four xylem-sap-feeding insect species were found within and bordering olive orchards across Salento during a survey carried out from October 2013 to December 2014: P. spumarius was the most abundant species on non-olive vegetation in olive orchards as well as on olive foliage and was the only species that consistently tested positive for the presence of X. fastidiosa using real-time PCR. P. spumarius, whose nymphs develop within spittle on weeds during the spring, are likely to move from weeds beneath olive trees to olive canopy during the dry period (May to October 2014). The first X. fastidiosa-infective P. spumarius were collected in May from olive canopy: all the individuals previously collected on weeds tested negative for the bacterium. Experiments demonstrated that P. spumarius transmitted X. fastidiosa from infected to uninfected olive plants. Moreover, P. spumarius acquired X. fastidiosa from several host plant species in the field, with the highest acquisition rate from olive, polygala and acacia. Scanning electron microscopy (SEM) revealed bacterial cells resembling X. fastidiosa in the foreguts of adult P. spumarius. The data presented here are essential to plan an effective IPM strategy and limit further spread of the fastidious bacterium.

Published
2017

16. Activity of natural occurring entomopathogenic fungi on nymphal and adult stages of Philaenus spumarius

Author

European Commission, Ministero dell'Agricoltura, della Sovranità Alimentare e delle Foreste, Bodino, Nicola, Barbera, Riccardo, González-Mas, Natalia, Demichelis, Stefano, Bosco, Domenico, Dolci, Paola, European Commission, Ministero dell'Agricoltura, della Sovranità Alimentare e delle Foreste, Bodino, Nicola, Barbera, Riccardo, González-Mas, Natalia, Demichelis, Stefano, Bosco, Domenico, and Dolci, Paola

Abstract

The spittlebug Philaenus spumarius (Hemiptera: Aphrophoridae) is the predominant vector of Xylella fastidiosa (Xanthomonadales: Xanthomonadaceae) in Apulia, Italy and the rest of Europe. Current control strategies of the insect vector rely on mechanical management of nymphal stages and insecticide application against adult populations. Entomopathogenic fungi (EPF) are biological control agents naturally attacking spittlebugs and may effectively reduce population levels of host species. Different experimental trials in controlled conditions have been performed to i) identify naturally occurring EPF on P, spumarius in Northwestern Italy, and ii) evaluate the potential for biocontrol of the isolated strains on both nymphal and adult stages of the spittlebug. Four EPF species were isolated from dead P. spumarius collected in semi-field conditions: Beauveria bassiana, Conidiobolus coronatus, Fusarium equiseti and Lecanicillium aphanocladii. All the fungal isolates showed entomopathogenic potential against nymphal stages of P. spumarius (≈ 45 % mortality), except for F. equiseti, in preliminary trials. No induced mortality was observed on adult stage. Lecanicillium aphanocladii was the most promising fungus and its pathogenicity against spittlebug nymphs was further tested in different formulations (conidia vs blastospores) and with natural adjuvants. Blastospore formulation was the most effective in killing nymphal instars and reducing the emergence rate of P, spumarius adults, reaching mortality levels (90%) similar to those of the commercial product Naturalis®, while no or adverse effect of natural adjuvants was recorded. The encouraging results of this study pave way for testing EPF isolates against P, spumarius in field conditions and find new environmentally friendly control strategies against insect vectors of X. fastidiosa.

Published
2024

21. Conceptual and mathematical modeling of insect-borne plant diseases: theory and application to flavescence doree in grapevine

Author

Federico, Maggi, Bosco, Domenico, and Marzachi', Cristina

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Insect-borne plant diseases recur commonly in wild plants and in agricultural crops, and are responsible for severe losses in terms of produce yield and monetary return. Mathematical models of insect-borne plant diseases are therefore an essential tool to help predicting the progression of an epidemic disease and aid in decision making when control strategies are to be implemented in the field. While retaining a generalized applicability of the proposed model to plant epidemics vectored by insects, we specifically investigated the epidemics of Flavescence dor\'ee phytoplasma (FD) in grapevine plant Vitis vinifera specifically transmitted by the leafhopper Scaphoideus titanus. The epidemiological model accounted for life-cycle stage of S. titanus, FD pathogen cycle within S. titanus and V. vinifera, vineyard setting, and agronomic practices. The model was comprehensively tested against biological S. titanus life cycle and FD epidemics data collected in various research sites in Piemonte, Italy, over multiple years. The work presented here represents a unique suite of governing equations tested on existing independent data and sets the basis for further modelling advances and possible applications to investigate effectiveness of real-case epidemics control strategies and scenarios.

Published
2014

22. Scaphoideus titanus forecasting and management: quo vadis?

Author

Gonella, Elena, Benelli, Giovanni, Arricau-Bouvery, Nathalie, Bosco, Domenico, Duso, Carlo, Dietrich, Christopher H., Galetto, Luciana, Rizzoli, Attilio, Jović, Jelena, Mazzoni, Valerio, Mori, Nicola, Nieri, Rachele, Roversi, Pio F., Strauss, Gudrun, Thiéry, Denis, Trivellone, Valeria, Virant-Doberlet, Meta, Lucchi, Andrea, and Alma, Alberto

Abstract

Scaphoideus titanus Ball (Hemiptera: Cicadellidae) is a major pest for European viticulture due to its high efficiency in the transmission of one of the most destructive pathogens for grapevine, namely flavescence dorée phytoplasmas. Although it plays a major role in spreading this disease, S. titanus is part of a complex epidemiological cycle involving several alternative vectors with variable relevance for phytoplasma spread. Here we provide an updated review on S. titanus monitoring and modelling, as well as the available tools for management of this pest and for limiting phytoplasma transmission and, thus, also spread. Insecticide-based control is examined; additional emphasis is placed on innovative and low-impact control approaches, such as vibrational mating disruption, biocontrol, and methods to reduce vector competence. We also discuss the main emerging challenges to the implementation of effective and sustainable control programs against S. titanus.

Published
2024
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23. Scaphoideus titanus up-to-the-minute: biology, ecology, and role as a vector

Author

Gonella, Elena, Benelli, Giovanni, Arricau-Bouvery, Nathalie, Bosco, Domenico, Duso, Carlo, Dietrich, Christopher H., Galetto, Luciana, Rizzoli, Attilio, Jović, Jelena, Mazzoni, Valerio, Mori, Nicola, Nieri, Rachele, Roversi, Pio F., Strauss, Gudrun, Thiéry, Denis, Trivellone, Valeria, Virant-Doberlet, Meta, Lucchi, Andrea, and Alma, Alberto

Abstract

Native to the Nearctic region, Scaphoideus titanus Ball (Hemiptera: Cicadellidae) has become a major threat for grapevine production after being unintentionally introduced into Europe, where it became the main vector of flavescence dorée phytoplasma, being mainly associated with the genus Vitis. Scaphoideus titanus is a highly efficient vector of the most important phytoplasma affecting grapevine. For this reason, compulsory insecticide treatments have been introduced against this pest in many European countries. Moreover, the continuous expansion of its geographical distribution makes this leafhopper a serious threat for several non-European Countries. In this article, we review the current knowledge about its taxonomy, morphology, biology, ecology, and its role as a vector. Finally, we point out the main challenges for research aimed at reducing S. titanus and flavescence dorée expansion across Europe and avoiding spread of the disease outside the Old World.

Published
2024
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25. Islets-on-Chip: A Tool for Real-Time Assessment of Islet Function Prior to Transplantation

Author

Raoux, Matthieu, primary, Lablanche, Sandrine, additional, Jaffredo, Manon, additional, Pirog, Antoine, additional, Benhamou, Pierre-Yves, additional, Lebreton, Fanny, additional, Wojtusciszyn, Anne, additional, Bosco, Domenico, additional, Berney, Thierry, additional, Renaud, Sylvie, additional, Lang, Jochen, additional, and Catargi, Bogdan, additional

Published
2023
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26. Coma

Author

Consoli, Domenico, primary, Galati, Franco, additional, Consoli, Arturo, additional, Bosco, Domenico, additional, Micieli, Giuseppe, additional, Serrati, Carlo, additional, Toni, Danilo, additional, and Cavallini, Anna, additional

Published
2020
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28. A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease

Author

Quattrone, Aldo, Morelli, Maurizio, Nigro, Salvatore, Quattrone, Andrea, Vescio, Basilio, Arabia, Gennarina, Nicoletti, Giuseppe, Nisticò, Rita, Salsone, Maria, Novellino, Fabiana, Barbagallo, Gaetano, Le Piane, Emilio, Pugliese, Pierfrancesco, Bosco, Domenico, Vaccaro, Maria Grazia, Chiriaco, Carmelina, Sabatini, Umberto, Vescio, Virginia, Stanà, Carlo, Rocca, Federico, Gullà, Domenico, and Caracciolo, Manuela

Published
2018
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29. Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial

Author

Malvezzi, Paolo, Tauveron, Igor, Roche, Béatrice, Noel, Christian, Frimat, Luc, Guerci, Bruno, Pernin, Nadine, Moisan, Anaick, Persoons, Virginie, Ezzouaoui, Rimed, Gmyr, Valery, Thony, Frédéric, Bricault, Yvan, Rodière, Mathieu, Sengel, Christian, Greget, Michel, Enescu, Iulian, Hazzan, Marc, Caiazzo, Robert, Torres, Fanelly, Le Mapihan, Kristel, Raverdy, Violetta, Pierredon, Marie-Ange, Valette, Pierre-Jean, Muller, Arnaud, Champagnac, Jean, Chaillous, Lucy, Dantal, Jacques, Cattan, Pierre, Riveline, Jean-Pierre, Moreau, François, Baltzinger, Philippe, Bahoune, Thibault, Lablanche, Sandrine, Vantyghem, Marie-Christine, Kessler, Laurence, Wojtusciszyn, Anne, Borot, Sophie, Thivolet, Charles, Girerd, Sophie, Bosco, Domenico, Bosson, Jean-Luc, Colin, Cyrille, Tetaz, Rachel, Logerot, Sophie, Kerr-Conte, Julie, Renard, Eric, Penfornis, Alfred, Morelon, Emmanuel, Buron, Fanny, Skaare, Kristina, Grguric, Gwen, Camillo-Brault, Coralie, Egelhofer, Harald, Benomar, Kanza, Badet, Lionel, Berney, Thierry, Pattou, François, and Benhamou, Pierre-Yves

Published
2018
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33. A map of open chromatin in human pancreatic islets

Author

Gaulton, Kyle J, Nammo, Takao, Pasquali, Lorenzo, Simon, Jeremy M, Giresi, Paul G, Fogarty, Marie P, Panhuis, Tami M, Mieczkowski, Piotr, Secchi, Antonio, Bosco, Domenico, Berney, Thierry, Montanya, Eduard, Mohlke, Karen L, Lieb, Jason D, and Ferrer, Jorge

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Digestive Diseases, Diabetes, Metabolic and endocrine, Binding Sites, Cells, Cultured, Chromatin, Chromatin Assembly and Disassembly, Chromosome Mapping, Diabetes Mellitus, Type 2, Formaldehyde, Genetic Predisposition to Disease, HeLa Cells, Humans, Islets of Langerhans, K562 Cells, Models, Biological, Oligonucleotide Array Sequence Analysis, Regulatory Sequences, Nucleic Acid, Sequence Analysis, DNA, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein, Hela Cells, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Tissue-specific transcriptional regulation is central to human disease. To identify regulatory DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted isolation of regulatory elements coupled with high-throughput sequencing (FAIRE-seq). We identified approximately 80,000 open chromatin sites. Comparison of FAIRE-seq data from islets to that from five non-islet cell lines revealed approximately 3,300 physically linked clusters of islet-selective open chromatin sites, which typically encompassed single genes that have islet-specific expression. We mapped sequence variants to open chromatin sites and found that rs7903146, a TCF7L2 intronic variant strongly associated with type 2 diabetes, is located in islet-selective open chromatin. We found that human islet samples heterozygous for rs7903146 showed allelic imbalance in islet FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at this locus acts in cis with local chromatin and regulatory changes. These findings illuminate the tissue-specific organization of cis-regulatory elements and show that FAIRE-seq can guide the identification of regulatory variants underlying disease susceptibility.

Published
2010

40. Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release.

Author

Jiménez-Sánchez, Cecilia, Sinturel, Flore, Mezza, Teresa, Loizides-Mangold, Ursula, Montoya, Jonathan Paz, Li, Lingzi, Di Giuseppe, Gianfranco, Quero, Giuseppe, Guessous, Idris, Jornayvaz, François, Schrauwen, Patrick, Stenvers, Dirk Jan, Alfieri, Sergio, Giaccari, Andrea, Berishvili, Ekaterine, Compagnon, Philippe, Bosco, Domenico, Riezman, Howard, Dibner, Charna, and Maechler, Pierre

Subjects
INSULIN, BLOOD lipids, TYPE 2 diabetes, GLYCEMIC control, BIOLOGICAL extinction
Abstract

In this study, we identified new lipid species associated with the loss of pancreatic β-cells triggering diabetes. We performed lipidomics measurements on serum from prediabetic mice lacking β-cell prohibitin-2 (a model of monogenic diabetes) patients without previous history of diabetes but scheduled for pancreaticoduodenectomy resulting in the acute reduction of their β-cell mass (∼50%), and patients with type 2 diabetes (T2D). We found lysophosphatidylinositols (lysoPIs) were the main circulating lipid species altered in prediabetic mice. The changes were confirmed in the patients with acute reduction of their β-cell mass and in those with T2D. Increased lysoPIs significantly correlated with HbA1c (reflecting glycemic control), fasting glycemia, and disposition index, and did not correlate with insulin resistance or obesity in human patients with T2D. INS-1E β-cells as well as pancreatic islets isolated from nondiabetic mice and human donors exposed to exogenous lysoPIs showed potentiated glucose-stimulated and basal insulin secretion. Finally, addition of exogenous lysoPIs partially rescued impaired glucose-stimulated insulin secretion in islets from mice and humans in the diabetic state. Overall, lysoPIs appear to be lipid species upregulated in the prediabetic stage associated with the loss of β-cells and that support the secretory function of the remaining β-cells. Article Highlights: Circulating lysophosphatidylinositols (lysoPIs) are increased in situations associated with β-cell loss in mice and humans such as (pre-)diabetes, and hemipancreatectomy. Pancreatic islets isolated from nondiabetic mice and human donors, as well as INS-1E β-cells, exposed to exogenous lysoPIs exhibited potentiated glucose-stimulated and basal insulin secretion. Addition of exogenous lysoPIs partially rescued impaired glucose-stimulated insulin secretion in islets from mice and humans in the diabetic state. LysoPIs appear as lipid species being upregulated already in the prediabetic stage associated with the loss of β-cells and supporting the function of the remaining β-cells. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Identification of newly synthetized proteins by mass spectrometry to understand palmitate-induced early cellular changes in pancreatic islets

Author

Cottet Dumoulin, David, primary, Fonseca, Laura Mar, additional, Bignard, Juliette, additional, Hanna, Reine, additional, Parnaud, Géraldine, additional, Lebreton, Fanny, additional, Bellofatto, Kevin, additional, Berishvili, Ekaterine, additional, Berney, Thierry, additional, and Bosco, Domenico, additional

Published
2023
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44. Intercellular contacts affect secretion and biosynthesis of pancreatic islet cells

Author

Cottet-Dumoulin, David, primary, Perrier, Quentin, additional, Lavallard, Vanessa, additional, Matthey-Doret, David, additional, Fonseca, Laura Mar, additional, Bignard, Juliette, additional, Hanna, Reine, additional, Parnaud, Geraldine, additional, Lebreton, Fanny, additional, Bellofatto, Kevin, additional, Berishvili, Ekaterine, additional, Berney, Thierry, additional, and Bosco, Domenico, additional

Published
2023
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47. Bioecological Traits of Spittlebugs and Their Implications for the Epidemiology and Control of the Xylella fastidiosa Epidemic in Apulia (Southern Italy)

Author

European Commission, Bodino, Nicola, Cavalieri, Vincenzo, Dongiovanni, Crescenza, Saponari, Maria, Bosco, Domenico, European Commission, Bodino, Nicola, Cavalieri, Vincenzo, Dongiovanni, Crescenza, Saponari, Maria, and Bosco, Domenico

Abstract

Spatial-temporal dynamics of spittlebug populations, together with transmission biology, are of major importance to outline the disease epidemiology of Xylella fastidiosa subsp. pauca in Apulian olive groves. The spread rate of X. fastidiosa is mainly influenced by (i) the pathogen colonization of the host plant; (ii) the acquisition of the pathogen by the vector from an infected plant, and its inoculation to healthy plants; (iii) the vector population dynamics and abundance at different spatial scales; and (iv) the dispersal of the vector. In this contribution we summarize the recent advances in research on insect vectors' traits-points ii, iii, and iv-focusing on those most relevant to X. fastidiosa epidemic in Apulia. Among the vectors' bioecological traits influencing the X. fastidiosa epidemic in olive trees, we emphasize the following: natural infectivity and transmission efficiency, phenological timing of both nymphal and adult stage, the role of seminatural vegetation as a vector reservoir in the agroecosystem and landscape, and preferential and directional dispersal capabilities. Despite the research on X. fastidiosa vectors carried out in Europe in the last decade, key uncertainties on insect vectors remain, hampering a thorough understanding of pathogen epidemiology and the development of effective and targeted management strategies. Our goal is to provide a structured and contextualized review of knowledge on X. fastidiosa vectors' key traits in the Apulian epidemic, highlighting information gaps and stimulating novel research pathways on X. fastidiosa pathosystems in Europe. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

Published
2023

48. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Author

Johnston, Natalie R., Mitchell, Ryan K., Haythorne, Elizabeth, Pessoa, Maria Paiva, Semplici, Francesca, Ferrer, Jorge, Piemonti, Lorenzo, Marchetti, Piero, Bugliani, Marco, Bosco, Domenico, Berishvili, Ekaterine, Duncanson, Philip, Watkinson, Michael, Broichhagen, Johannes, Trauner, Dirk, Rutter, Guy A., and Hodson, David J.

Published
2016
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