444 results on '"Bosnic-Anticevich, S."'
Search Results
2. Advancing Digital Solutions to Overcome Longstanding Barriers in Asthma and COPD Management
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Bosnic-Anticevich S, Bakerly ND, Chrystyn H, Hew M, and van der Palen J
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asthma ,chronic obstructive pulmonary disease ,technology ,device ,data ,Medicine (General) ,R5-920 - Abstract
Sinthia Bosnic-Anticevich,1 Nawar Diar Bakerly,2 Henry Chrystyn,3 Mark Hew,4 Job van der Palen5 1Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia; 2Manchester Metropolitan University, Manchester, United Kingdom, Salford Royal NHS Foundation Trust, Manchester, UK; 3Inhalation Consultancy Ltd, Leeds, UK; 4Allergy, Asthma, and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia; 5Medical School Twente, Medisch Spectrum Twente, Enschede, the Netherlands, and Section Cognition, Data and Education, University of Twente, Enschede, the NetherlandsCorrespondence: Sinthia Bosnic-Anticevich, Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, 2037, NSW, Australia, Tel +61 414 015 614, Email sinthia.bosnic-anticevich@sydney.edu.auAbstract: Maintenance therapy delivered via inhaler is central to asthma and chronic obstructive pulmonary disease (COPD) management. Poor adherence to inhaled medication and errors in inhalation technique have long represented major barriers to the optimal management of these chronic conditions. Technological innovations may provide a means of overcoming these barriers. This narrative review examines ongoing advances in digital technologies relevant to asthma and COPD with the potential to inform clinical decision-making and improve patient care. Digital inhaler devices linked to mobile apps can help bring about changes in patients’ behaviors and attitudes towards disease management, particularly when they build in elements of interactivity and gamification. They can also support ongoing technique education, empowering patients and helping providers maximize the value of consultations and develop effective action plans informed by insights into the patient’s inhaler use patterns and their respiratory health. When combined with innovative techniques such as machine learning, digital devices have the potential to predict exacerbations and prompt pre-emptive intervention. Finally, digital devices may support an advanced precision medicine approach to respiratory disease management and help support shared decision-making. Further work is needed to increase uptake of digital devices and integrate their use into care pathways before their full potential in personalized asthma and COPD management can be realized.Keywords: asthma, chronic obstructive pulmonary disease, technology, device, data
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- 2023
3. Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study
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Sousa-Pinto, B., Louis, R., Anto, J.M., Amaral, R., Sá-Sousa, A., Czarlewski, W., Brussino, L., Canonica, G.W., Chaves Loureiro, C., Cruz, A.A., Gemicioglu, B., Haahtela, T., Kupczyk, M., Kvedariene, V., Larenas-Linnemann, D.E., Okamoto, Y., Ollert, M., Pfaar, O., Pham-Thi, N., Puggioni, F., Regateiro, F.S., Romantowski, J., Sastre, J., Scichilone, N., Taborda-Barata, L., Ventura, M.T., Agache, I., Bedbrook, A., Becker, S., Bergmann, K.C., Bosnic-Anticevich, S., Bonini, M., Boulet, L.-P., Brusselle, G., Buhl, R., Cecchi, L., Charpin, D., de Blay, F., Del Giacco, S., Ivancevich, J.C., Jutel, M., Klimek, L., Kraxner, H., Kuna, P., Laune, D., Makela, M., Morais-Almeida, M., Nadif, R., Niedoszytko, M., Papadopoulos, N.G., Papi, A., Patella, V., Pétré, B., Rivero Yeverino, D., Robalo Cordeiro, C., Roche, N., Rouadi, P.W., Samolinski, B., Savouré, M., Shamji, M.H., Sheikh, A., Suppli Ulrik, C., Usmani, O.S., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Fonseca, J.A., Costa, E.M., and Bousquet, J.
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- 2023
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4. Uncovering Acute Exacerbations Via Reliever Use Patterns Using Digihaler Inhaler Data
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Lugogo, N.L., primary, Levy, M.L., additional, Kocks, J., additional, Safioti, G., additional, Brown, R., additional, Bosnic-Anticevich, S., additional, and Sagalovich, K., additional
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- 2024
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5. Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-Based Cohort Study from UK Primary Care
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Busby J, Price D, Al-Lehebi R, Bosnic-Anticevich S, van Boven JFM, Emmanuel B, FitzGerald JM, Gaga M, Hansen S, Hew M, Iwanaga T, Larenas Linnemann D, Mahboub B, Mitchell P, Morrone D, Pham J, Porsbjerg C, Roche N, Wang E, Eleangovan N, and Heaney LG
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asthma ,socioeconomic status ,disparities ,Immunologic diseases. Allergy ,RC581-607 - Abstract
John Busby,1 David Price,2– 4 Riyad Al-Lehebi,5 Sinthia Bosnic-Anticevich,6– 8 Job FM van Boven,9 Benjamin Emmanuel,10 J Mark FitzGerald,11 Mina Gaga,12 Susanne Hansen,13,14 Mark Hew,15,16 Takashi Iwanaga,17 Désirée Larenas Linnemann,18 Bassam Mahboub,19,20 Patrick Mitchell,21 Daniela Morrone,22 Jonathan Pham,15,23 Celeste Porsbjerg,14 Nicolas Roche,24,25 Eileen Wang,26,27 Neva Eleangovan,2,3 Liam G Heaney28 1Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland; 2Optimum Patient Care, Cambridge, UK; 3Observational and Pragmatic Research Institute, Singapore, Singapore; 4Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; 5Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia; 6Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; 7Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia; 8Central Sydney Local Area Health District, Sydney, Australia; 9Department of Clinical Pharmacy & Pharmacology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 10BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA; 11Department of Medicine, The University of British Columbia, Vancouver, Canada; 12 7th Respiratory Medicine Department and Asthma Centre, Athens Chest Hospital, Athens, Greece; 13Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; 14Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark; 15Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Australia; 16Public Health and Preventive Medicine, Monash University, Melbourne, Australia; 17Center for General Medical Education and Clinical Training, Kindai University Hospital, Osakasayama, Japan; 18Directora Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico; 19College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 20Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates; 21Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; 22Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy; 23Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Melbourne, Australia; 24Respiratory Medicine, Cochin Hospital, APHP.Centre, Paris, France; 25University of Paris, Cochin Institute (UMR1016), Paris, France; 26Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA; 27Division of Allergy & Clinical Immunology, Department of Internal Medicine, University of Colorado School of Medicine, Aurora, CO, USA; 28Wellcome-Wolfson Centre for Experimental Medicine, Queen’s University Belfast, Belfast, Northern IrelandCorrespondence: David PriceCentre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UKTel +65 6962 3627Email dprice@opri.sgIntroduction: Asthma morbidity and health-care utilization are known to exhibit a steep socioeconomic gradient. Further investigation into the modulators of this effect is required to identify potentially modifiable factors.Methods: We identified a cohort of patients with asthma from the Optimum Patient Care Research Database (OPCRD). We compared demographics, clinical variables, and health-care utilization by quintile of the UK 2011 Indices of Multiple Deprivation based on the location of the patients’ general practice. Multivariable analyses were conducted using generalized linear models adjusting for year, age, and sex. We conducted subgroup analyses and interaction tests to investigate the impact of deprivation by age, sex, ethnicity, and treatment step.Results: Our analysis included 127,040 patients with asthma. Patients from the most deprived socio-economic status (SES) quintile were more likely to report uncontrolled disease (OR: 1.54, 95% CI: 1.16, 2.05) and to have an exacerbation during follow-up (OR: 1.27, 95% CI: 1.13, 1.42) than the least deprived quintile. They had higher blood eosinophils (ratio: 1.03; 95% CI: 1.00, 1.06) and decreased peak flow (ratio: 0.95, 95% CI: 0.94, 0.97) when compared to those in the least deprived quintile. The effect of deprivation on asthma control was greater among those aged over 75 years (OR = 1.81, 95% CI: 1.20, 2.73) compared to those aged less than 35 years (OR: 1.22, 95% CI: 0.85, 1.74; pinteraction=0.019). Similarly, socioeconomic disparities in exacerbations were larger among those from ethnic minority groups (OR: 1.94, 95% CI: 1.40, 2.68) than white patients (OR: 1.24, 95% CI: 1.10, 1.39; pinteraction=0.012).Conclusion: We found worse disease control and increased exacerbation rates among patients with asthma from more deprived areas. There was evidence that the magnitude of socioeconomic disparities was elevated among older patients and those from ethnic minority groups. The drivers of these differences require further exploration.Keywords: asthma, socioeconomic status, disparities
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- 2021
6. The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients
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Kritikos V, Price D, Papi A, Infantino A, Ställberg B, Ryan D, Lavorini F, Chrystyn H, Haughney J, Lisspers K, Gruffydd-Jones K, Román Rodríguez M, Høegh Henrichsen S, van der Molen T, Carter V, and Bosnic-Anticevich S
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asthma symptom control ,comorbidities ,oral steroids ,preventer ,reliever ,side-effects ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Vicky Kritikos,1,2 David Price,3– 5 Alberto Papi,6 Antonio Infantino,7 Björn Ställberg,8 Dermot Ryan,3,9 Federico Lavorini,10 Henry Chrystyn,11 John Haughney,12 Karin Lisspers,8 Kevin Gruffydd-Jones,13 Miguel Román Rodríguez,14 Svein Høegh Henrichsen,15 Thys van der Molen,16 Victoria Carter,3,4 Sinthia Bosnic-Anticevich1,17,18 1Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia; 2Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 3Optimum Patient Care, Cambridge, UK; 4Observational and Pragmatic Research Institute, Singapore, Singapore; 5Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; 6Respiratory Medicine, University of Ferrara, Ferrara, Italy; 7Special Interest Respiratory Area, Italian Interdisciplinary Society for Primary Care, Bari, Italy; 8Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 9Usher Institute, University of Edinburgh, Edinburgh, UK; 10Department Experimental and Clinical Medicine, University of Florence, Florence, Italy; 11Inhalation Consultancy Ltd, Leeds, UK; 12NHS Greater Glasgow & Clyde R&D, Glasgow, UK; 13Box Surgery, Box, UK; 14Primary Care Respiratory Research Unit Instituto De Investigación Sanitaria De Baleares (IdISBa), Palma, Spain; 15Department of Primary Health Care Services, Norwegian Directorate of Health, Oslo, Norway; 16Department of Primary Care, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; 17Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; 18Central Sydney Local Area Health District, Sydney, NSW, AustraliaCorrespondence: Vicky KritikosWoolcock Institute of Medical Research, Glebe, Sydney, NSW, AustraliaTel +61 4 0299 5125Fax +61 2 9114 0014Email vicky.kritikos@sydney.edu.auPurpose: There is a dearth of research regarding the prevalence and nature of patient-reported rhinitis and its relationship with risk of asthma exacerbations. The aim of this study was to (i) determine the prevalence, severity and treatment of self-reported rhinitis symptoms among adults aged ≥ 18 years with asthma treated at Global Initiative for Asthma (GINA) Step 3 and above and (ii) compare the demographics, clinical characteristics, medication use, side-effects and healthcare practitioner review between patients who report rhinitis symptoms and those who do not and (iii) determine whether patient-reported rhinitis is associated with risk of asthma exacerbations in the total patient sample.Patients and Methods: This analysis used data from the iHARP (Initiative Helping Asthma in Real-life Patients) asthma review service – a cross-sectional observational study (2011 and 2014) in seven countries that captured data on patient demographics, rhinitis symptoms, asthma symptoms, indicators of exacerbations, medication use, oropharyngeal effects and side-effects, using practitioner- and patient-reported questionnaires. Comparisons between patients with and without rhinitis were tested. Univariate logistic regression was used to identify variables associated with risk of exacerbations for entry into multivariable logistic regression.Results: This report contains data from 4274 patients: 67.4% (2881/4274) reported rhinitis symptoms and of which 65.7% (1894/2881) had not received a doctor diagnosis; 36.5% (1052/2881) had moderate-severe rhinitis, 12.4% (358/2881) had used intranasal corticosteroids and 19.8% (569/2881) oral antihistamines. Patients with coexisting moderate-severe rhinitis were more likely to have GINA-defined uncontrolled asthma than those with mild rhinitis or no rhinitis. Moderate-severe rhinitis was associated with 40% increased risk of asthma exacerbations (OR=1.40, 95% CI: 1.02– 1.90).Conclusion: This study identified a major gap in the diagnosis and management of rhinitis in a cohort of people with asthma treated at GINA Step 3 and above who are managed in general practice. It highlights the need for practitioners to identify, evaluate and optimally treat rhinitis in adults with asthma, which is a significant factor associated with exacerbation risk.Keywords: asthma symptom control, comorbidities, oral steroids, preventer, reliever, side-effects
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- 2020
7. WILDFIRE-ASSOCIATED INCREASE IN RELIEVER USE AMONG US ASTHMA PATIENTS: DATA FROM A DIGITAL HEALTH PLATFORM
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Burnette, A., primary, Brown, R., additional, Hill, T., additional, Boe, A., additional, Bosnic-Anticevich, S., additional, Dangol, R., additional, Khanikova, O., additional, and Safioti, G., additional
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- 2023
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8. DIGIHALER SYSTEM USE BY HEALTHCARE PROFESSIONALS AND APP CONNECTIVITY IN ASTHMA PATIENTS: A PRAGMATIC STUDY
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Mosnaim, G., primary, Hoyte, F., additional, Safioti, G., additional, Hill, T., additional, Bosnic-Anticevich, S., additional, Dangol, R., additional, Sagalovich, K., additional, and Wechsler, M., additional
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- 2023
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9. Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study
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Samreth, D., Arnavielhe, S., Ingenrieth, F., Bedbrook, A., Onorato, G.L., Murray, R., Almeida, R., Mizani, M.A., Fonseca, J., Costa, E., Malva, J., Morais-Almeida, M., Pereira, A.M., Todo-Bom, A., Menditto, E., Stellato, C., Ventura, M.T., Larenas-Linnemann, D., Fuentes-Pérez, J-M., Huerta-Villalobos, Y.R., Cruz, A.A., Stelmach, R., da Silva, J., Emuzyte, R., Kvedariene, V., Valiulis, A., Annesi-Maesano, I., Bosse, I., Demoly, P., Devillier, P., Fontaine, J.F., Kuna, P., Samolinski, B., Klimek, L., Mösges, R., Pfaar, O., Shamai, S., Bewick, M., Ryan, D., Sheikh, A., Anto, J.M., Cardona, V., Mullol, J., Valero, A., Chavannes, N.H., Fokkens, W.J., Reitsma, S., Roller-Wirnsberger, R.E., Tomazic, P.V., Haahtela, T., Toppila-Salmi, S., Valovirta, E., Makris, M., Papadopoulos, N.G., Prokopakis, E.P., Psarros, F., Gemicioğlu, B., Yorgancioglu, A., Bindslev-Jensen, C., Eller, E., Kull, I., Wickman, M., Bachert, C., Hellings, P.W., Pugin, B., Bosnic-Anticevich, S., O’Hehir, R.E., Kolek, V., Sova, M., Wehner, K., De Vries, G., van Eerd, M., Laune, D., Wittmann, J., Bousquet, J., and Poncelet, P., the MASK study group
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- 2018
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10. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
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Bousquet, J., primary, Melén, E., additional, Haahtela, T., additional, Koppelman, G. H., additional, Togias, A., additional, Valenta, R., additional, Akdis, C. A., additional, Czarlewski, W., additional, Rothenberg, M., additional, Valiulis, A., additional, Wickman, M., additional, Akdis, M., additional, Aguilar, D., additional, Bedbrook, A., additional, Bindslev‐Jensen, C., additional, Bosnic‐Anticevich, S., additional, Boulet, L. P., additional, Brightling, C. E., additional, Brussino, L., additional, Burte, E., additional, Bustamante, M., additional, Canonica, G. W., additional, Cecchi, L., additional, Celedon, J. C., additional, Chaves Loureiro, C., additional, Costa, E., additional, Cruz, A. A., additional, Erhola, M., additional, Gemicioglu, B., additional, Fokkens, W. J., additional, Garcia‐Aymerich, J., additional, Guerra, S., additional, Heinrich, J., additional, Ivancevich, J. C., additional, Keil, T., additional, Klimek, L., additional, Kuna, P., additional, Kupczyk, M., additional, Kvedariene, V., additional, Larenas‐Linnemann, D. E., additional, Lemonnier, N., additional, Lodrup Carlsen, K. C., additional, Louis, R., additional, Makela, M., additional, Makris, M., additional, Maurer, M., additional, Momas, I., additional, Morais‐Almeida, M., additional, Mullol, J., additional, Naclerio, R. N., additional, Nadeau, K., additional, Nadif, R., additional, Niedoszytko, M., additional, Okamoto, Y., additional, Ollert, M., additional, Papadopoulos, N. G., additional, Passalacqua, G., additional, Patella, V., additional, Pawankar, R., additional, Pham‐Thi, N., additional, Pfaar, O., additional, Regateiro, F. S., additional, Ring, J., additional, Rouadi, P. W., additional, Samolinski, B., additional, Sastre, J., additional, Savouré, M., additional, Scichilone, N., additional, Shamji, M. H., additional, Sheikh, A., additional, Siroux, V., additional, Sousa‐Pinto, B., additional, Standl, M., additional, Sunyer, J., additional, Taborda‐Barata, L., additional, Toppila‐Salmi, S., additional, Torres, M. J., additional, Tsiligianni, I., additional, Valovirta, E., additional, Vandenplas, O., additional, Ventura, M. T., additional, Weiss, S., additional, Yorgancioglu, A., additional, Zhang, L., additional, Abdul Latiff, A. H., additional, Aberer, W., additional, Agache, I., additional, Al‐Ahmad, M., additional, Alobid, I., additional, Ansotegui, I. J., additional, Arshad, S. H., additional, Asayag, E., additional, Barbara, C., additional, Baharudin, A., additional, Battur, L., additional, Bennoor, K. S., additional, Berghea, E. C., additional, Bergmann, K. C., additional, Bernstein, D., additional, Bewick, M., additional, Blain, H., additional, Bonini, M., additional, Braido, F., additional, Buhl, R., additional, Bumbacea, R. S., additional, Bush, A., additional, Calderon, M., additional, Calvo‐Gil, M., additional, Camargos, P., additional, Caraballo, L., additional, Cardona, V., additional, Carr, W., additional, Carreiro‐Martins, P., additional, Casale, T., additional, Cepeda Sarabia, A. M., additional, Chandrasekharan, R., additional, Charpin, D., additional, Chen, Y. Z., additional, Cherrez‐Ojeda, I., additional, Chivato, T., additional, Chkhartishvili, E., additional, Christoff, G., additional, Chu, D. K., additional, Cingi, C., additional, Correia de Sousa, J., additional, Corrigan, C., additional, Custovic, A., additional, D’Amato, G., additional, Del Giacco, S., additional, De Blay, F., additional, Devillier, P., additional, Didier, A., additional, do Ceu Teixeira, M., additional, Dokic, D., additional, Douagui, H., additional, Doulaptsi, M., additional, Durham, S., additional, Dykewicz, M., additional, Eiwegger, T., additional, El‐Sayed, Z. A., additional, Emuzyte, R., additional, Fiocchi, A., additional, Fyhrquist, N., additional, Gomez, R. M., additional, Gotua, M., additional, Guzman, M. A., additional, Hagemann, J., additional, Hamamah, S., additional, Halken, S., additional, Halpin, D. M. G., additional, Hofmann, M., additional, Hossny, E., additional, Hrubiško, M., additional, Irani, C., additional, Ispayeva, Z., additional, Jares, E., additional, Jartti, T., additional, Jassem, E., additional, Julge, K., additional, Just, J., additional, Jutel, M., additional, Kaidashev, I., additional, Kalayci, O., additional, Kalyoncu, A. F., additional, Kardas, P., additional, Kirenga, B., additional, Kraxner, H., additional, Kull, I., additional, Kulus, M., additional, La Grutta, S., additional, Lau, S., additional, Le Tuyet Thi, L., additional, Levin, M., additional, Lipworth, B., additional, Lourenço, O., additional, Mahboub, B., additional, Martinez‐Infante, E., additional, Matricardi, P., additional, Miculinic, N., additional, Migueres, N., additional, Mihaltan, F., additional, Mohammad, Y., additional, Moniuszko, M., additional, Montefort, S., additional, Neffen, H., additional, Nekam, K., additional, Nunes, E., additional, Nyembue Tshipukane, D., additional, O’Hehir, R., additional, Ogulur, I., additional, Ohta, K., additional, Okubo, K., additional, Ouedraogo, S., additional, Olze, H., additional, Pali‐Schöll, I., additional, Palomares, O., additional, Palosuo, K., additional, Panaitescu, C., additional, Panzner, P., additional, Park, H. S., additional, Pitsios, C., additional, Plavec, D., additional, Popov, T. A., additional, Puggioni, F., additional, Quirce, S., additional, Recto, M., additional, Repka‐Ramirez, M. S., additional, Robalo Cordeiro, C., additional, Roche, N., additional, Rodriguez‐Gonzalez, M., additional, Romantowski, J., additional, Rosario Filho, N., additional, Rottem, M., additional, Sagara, H., additional, Serpa, F. S., additional, Sayah, Z., additional, Scheire, S., additional, Schmid‐Grendelmeier, P., additional, Sisul, J. C., additional, Sole, D., additional, Soto‐Martinez, M., additional, Sova, M., additional, Sperl, A., additional, Spranger, O., additional, Stelmach, R., additional, Suppli Ulrik, C., additional, Thomas, M., additional, To, T., additional, Todo‐Bom, A., additional, Tomazic, P. V., additional, Urrutia‐Pereira, M., additional, Valentin‐Rostan, M., additional, Van Ganse, E., additional, van Hage, M., additional, Vasankari, T., additional, Vichyanond, P., additional, Viegi, G., additional, Wallace, D., additional, Wang, D. Y., additional, Williams, S., additional, Worm, M., additional, Yiallouros, P., additional, Yusuf, O., additional, Zaitoun, F., additional, Zernotti, M., additional, Zidarn, M., additional, Zuberbier, J., additional, Fonseca, J. A., additional, Zuberbier, T., additional, and Anto, J. M., additional
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- 2023
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11. The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes
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Bosnic-Anticevich S, Chrystyn H, Costello RW, Dolovich MB, Fletcher MJ, Lavorini F, Rodríguez-Roisin R, Ryan D, Wan Yau Ming S, and Price DB
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chronic obstructive pulmonary disease ,inhalation technique ,exacerbations ,inhaler devices ,observational ,matched cohort ,Diseases of the respiratory system ,RC705-779 - Abstract
Sinthia Bosnic-Anticevich,1 Henry Chrystyn,2 Richard W Costello,3,4 Myrna B Dolovich,5 Monica J Fletcher,6 Federico Lavorini,7 Roberto Rodríguez-Roisin,8 Dermot Ryan,9,10 Simon Wan Yau Ming,2 David B Price2,11 1Woolcock Institute of Medical Research, School of Medical Sciences, University of Sydney and Sydney Local Health District, Sydney, NSW, Australia; 2Observational and Pragmatic Research Institute Pte Ltd, Singapore; 3RCSI Medicine, Royal College of Surgeons, 4RCSI Education & Research Centre, Beaumont Hospital, Beaumont, Dublin, Ireland; 5Department of Medicine, Respirology, McMaster University, ON, Canada; 6Education for Health, Warwick, UK; 7Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 8Respiratory Institute, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain; 9Optimum Patient Care, Cambridge, 10Centre for Population Health Sciences, University of Edinburgh, Edinburgh, 11Academic Primary Care, University of Aberdeen, Aberdeen, UK Background: Patients with COPD may be prescribed multiple inhalers as part of their treatment regimen, which require different inhalation techniques. Previous literature has shown that the effectiveness of inhaled treatment can be adversely affected by incorrect inhaler technique. Prescribing a range of device types could worsen this problem, leading to poorer outcomes in COPD patients, but the impact is not yet known. Aims: To compare clinical outcomes of COPD patients who use devices requiring similar inhalation technique with those who use devices with mixed techniques. Methods: A matched cohort design was used, with 2 years of data from the Optimum Patient Care Research Database. Matching variables were established from a baseline year of follow-up data, and two cohorts were formed: a “similar-devices cohort” and a “mixed-devices cohort”. COPD-related events were recorded during an outcome year of follow-up. The primary outcome measure was an incidence rate ratio (IRR) comparing the rate of exacerbations between study cohorts. A secondary outcome compared average daily use of short-acting beta agonist (SABA). Results: The final study sample contained 8,225 patients in each cohort (mean age 67 [SD, 10], 57% males, 37% current smokers). Patients in the similar-devices cohort had a lower rate of exacerbations compared with those in the mixed-devices cohort (adjusted IRR 0.82, 95% confidence interval [CI] 0.80–0.84) and were less likely to be in a higher-dose SABA group (adjusted proportional odds ratio 0.54, 95% CI 0.51–0.57). Conclusion: COPD patients who were prescribed one or more additional inhaler devices requiring similar inhalation techniques to their previous device(s) showed better outcomes than those who were prescribed devices requiring different techniques. Keywords: chronic obstructive pulmonary disease, inhalation technique, exacerbations, inhaler devices, observational, matched cohort
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- 2016
12. Rhinitis associated with asthma is distinct from rhinitis alone: The <scp>ARIA‐MeDALL</scp> hypothesis
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J., Melén, E., Haahtela, T., Koppelman, G. H., Togias, A., Valenta, R., Akdis, C. A., Czarlewski, W., Rothenberg, M., Valiulis, A., Wickmann, M., Aguilar, D., Akdis, M., Ansotegui, I. J., Barbara, C., Bedbrook, A., Bindslev Jensen, C., Bosnic‐Anticevich, S., Boulet, L. P., Brightling, C. E., Brussino, L., Burte, E., Bustamante, M., Canonica, G. W., Cecchi, L., Celedon, J. C., Chaves‐Loureiro, C., Costa, E., Cruz, A. A., Erhola, M., Gemicioglu, B., Fokkens, W. J., Garcia Aymerich, J., Guerra, S., Heinrich, J., Ivancevich, J. C., Keil, T., Klimek, L., Kuna, P., Kupczyk, M., Kvedariene, V., Larenas‐Linnemann, D. E., Lemonnier, N., Lodrup Carlsen, K. C., Louis, R., Makris, M., Maurer, M., Momas, I., Morais‐Almeida, M., Mullol, J., Naclerio, R. N., Nadeau, K., Nadif, R., Niedoszytko, M., Okamoto, Y., Ollert, M., Papadopoulos, N. G., Passalacqua, G., Patella, V., Pawankar, R., Pham‐Thi, N., Pfaar, O., Regateiro, F. S., Ring, J., Rouadi, P. W., Samolinski, B., Sastre, J., Savouré, M., Scichilone, N., Shamji, M. H., Sheikh, A., Siroux, V., Sousa‐Pinto, B., Standl, M., Sunyer, J., Taborda‐Barata, L., Toppila‐Salmi, S., Torres, M. J., Tsiligianni, I., Valovirta, E., Vandenplas, Olivier, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J., Melén, E., Haahtela, T., Koppelman, G. H., Togias, A., Valenta, R., Akdis, C. A., Czarlewski, W., Rothenberg, M., Valiulis, A., Wickmann, M., Aguilar, D., Akdis, M., Ansotegui, I. J., Barbara, C., Bedbrook, A., Bindslev Jensen, C., Bosnic‐Anticevich, S., Boulet, L. P., Brightling, C. E., Brussino, L., Burte, E., Bustamante, M., Canonica, G. W., Cecchi, L., Celedon, J. C., Chaves‐Loureiro, C., Costa, E., Cruz, A. A., Erhola, M., Gemicioglu, B., Fokkens, W. J., Garcia Aymerich, J., Guerra, S., Heinrich, J., Ivancevich, J. C., Keil, T., Klimek, L., Kuna, P., Kupczyk, M., Kvedariene, V., Larenas‐Linnemann, D. E., Lemonnier, N., Lodrup Carlsen, K. C., Louis, R., Makris, M., Maurer, M., Momas, I., Morais‐Almeida, M., Mullol, J., Naclerio, R. N., Nadeau, K., Nadif, R., Niedoszytko, M., Okamoto, Y., Ollert, M., Papadopoulos, N. G., Passalacqua, G., Patella, V., Pawankar, R., Pham‐Thi, N., Pfaar, O., Regateiro, F. S., Ring, J., Rouadi, P. W., Samolinski, B., Sastre, J., Savouré, M., Scichilone, N., Shamji, M. H., Sheikh, A., Siroux, V., Sousa‐Pinto, B., Standl, M., Sunyer, J., Taborda‐Barata, L., Toppila‐Salmi, S., Torres, M. J., Tsiligianni, I., Valovirta, E., and Vandenplas, Olivier
- Abstract
Asthma, rhinitis and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease", coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitisation and multimorbidity, (iii) advances in mHealth for novel phenotype definition, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis". This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitisation patterns (mono- or pauci-sensitisation versus polysensitisation), (iii) severity of symptoms and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and auto-immune diseases.
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- 2023
13. Identifying critical inhalation technique errors in Dry Powder Inhaler use in patients with COPD based on the association with health status and exacerbations: findings from the multi-country cross-sectional observational PIFotal study.
- Author
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Kocks, J., Bosnic-Anticevich, S., Cooten, J. van, Correia de Sousa, J., Cvetkovski, B., Dekhuijzen, R., Dijk, L., Garcia Pardo, M., Gardev, A., Gawlik, R., Ham, I. van der, Janse, Y., Lavorini, F., Maricoto, T., Meijer, J., Metz, B., Price, D., Roman Rodriguez, M., Schuttel, K., Stoker, N., Tsiligianni, I., Usmani, O., Voorham, J., Leving, M.T., Kocks, J., Bosnic-Anticevich, S., Cooten, J. van, Correia de Sousa, J., Cvetkovski, B., Dekhuijzen, R., Dijk, L., Garcia Pardo, M., Gardev, A., Gawlik, R., Ham, I. van der, Janse, Y., Lavorini, F., Maricoto, T., Meijer, J., Metz, B., Price, D., Roman Rodriguez, M., Schuttel, K., Stoker, N., Tsiligianni, I., Usmani, O., Voorham, J., and Leving, M.T.
- Abstract
Contains fulltext : 295931.pdf (Publisher’s version ) (Open Access), BACKGROUND: Correct inhaler use depends on a complex interplay of factors, including device preparation and generating sufficient inspiratory flow. It is currently unknown which inhalation technique errors can be considered critical in Chronic Obstructive Pulmonary Disease (COPD) patients on Dry Powder Inhaler (DPI) maintenance therapy. OBJECTIVE: To investigate the association between inhalation technique errors and health status or exacerbations in patients with COPD. Additionally, the association between the number of errors and COPD outcomes was determined. METHODS: The PIFotal study is a cross-sectional multi-country observational study in a primary care setting, including 1434 COPD patients aged ≥ 40 years (50.1% female; mean age 69.2 yrs) using a DPI for their maintenance therapy. Inhalation technique was video recorded and scored by two independent researchers using inhaler-specific checklists. Health status was assessed with two questionnaires; the Clinical COPD Questionnaire (CCQ) and the COPD Assessment Test (CAT). The number of moderate and severe exacerbations in the past 12 months was recorded. Critical errors were identified based on their association with health status or exacerbations through multi-level prediction models adjusted for identified confounding. RESULTS: Errors in inhalation technique steps 'Breathe in', 'Hold breath', and 'Breathe out calmly after inhalation' were significantly associated with poorer CCQ and CAT outcomes and thus deemed critical. None of the errors were significantly associated with moderate exacerbations. Patients with errors 'Preparation', 'Hold inhaler in correct position during inhalation', and 'Breathe in' had significantly more severe exacerbations, and therefore these errors were also deemed critical. 81.3% of patients with COPD made at least one critical error. Specific combinations of errors were associated with worse outcomes. The more inhalation technique errors identified, the poorer the health status and t
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- 2023
14. Rhinitis associated with asthma is distinct from rhinitis alone:The ARIA-MeDALL hypothesis
- Author
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Bousquet, J, Melén, E, Haahtela, T, Koppelman, G H, Togias, A, Valenta, R, Akdis, C A, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickman, M, Akdis, M, Aguilar, D, Bedbrook, A, Bindslev-Jensen, C, Bosnic-Anticevich, S, Boulet, L P, Brightling, C E, Brussino, L, Burte, E, Bustamante, M, Canonica, G W, Cecchi, L, Celedon, J C, Chaves Loureiro, C, Costa, E, Cruz, A A, Erhola, M, Gemicioglu, B, Fokkens, W J, Garcia-Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, J C, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Lemonnier, N, Lodrup Carlsen, K C, Louis, R, Makela, M, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, R N, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, N G, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, F S, Ring, J, Rouadi, P W, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, M H, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, M J, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, M T, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, A H, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Ansotegui, I J, Arshad, S H, Asayag, E, Barbara, C, Baharudin, A, Battur, L, Bennoor, K S, Berghea, E C, Bergmann, K C, Bernstein, D, Bewick, M, Blain, H, Bonini, M, Braido, F, Buhl, R, Bumbacea, R S, Bush, A, Calderon, M, Calvo-Gil, M, Camargos, P, Caraballo, L, Cardona, V, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, A M, Chandrasekharan, R, Charpin, D, Chen, Y Z, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Christoff, G, Chu, D K, Cingi, C, Correia de Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, Z A, Emuzyte, R, Fiocchi, A, Fyhrquist, N, Gomez, R M, Gotua, M, Guzman, M A, Hagemann, J, Hamamah, S, Halken, S, Halpin, D M G, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, A F, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Grutta, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Martinez-Infante, E, Matricardi, P, Miculinic, N, Migueres, N, Mihaltan, F, Mohammad, Y, Moniuszko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Park, H S, Pitsios, C, Plavec, D, Popov, T A, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, M S, Robalo Cordeiro, C, Roche, N, Rodriguez-Gonzalez, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Serpa, F S, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, J C, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Tomazic, P V, Urrutia-Pereira, M, Valentin-Rostan, M, Van Ganse, E, van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, D Y, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, J A, Zuberbier, T, Anto, J M, Bousquet, J, Melén, E, Haahtela, T, Koppelman, G H, Togias, A, Valenta, R, Akdis, C A, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickman, M, Akdis, M, Aguilar, D, Bedbrook, A, Bindslev-Jensen, C, Bosnic-Anticevich, S, Boulet, L P, Brightling, C E, Brussino, L, Burte, E, Bustamante, M, Canonica, G W, Cecchi, L, Celedon, J C, Chaves Loureiro, C, Costa, E, Cruz, A A, Erhola, M, Gemicioglu, B, Fokkens, W J, Garcia-Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, J C, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Lemonnier, N, Lodrup Carlsen, K C, Louis, R, Makela, M, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, R N, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, N G, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, F S, Ring, J, Rouadi, P W, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, M H, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, M J, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, M T, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, A H, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Ansotegui, I J, Arshad, S H, Asayag, E, Barbara, C, Baharudin, A, Battur, L, Bennoor, K S, Berghea, E C, Bergmann, K C, Bernstein, D, Bewick, M, Blain, H, Bonini, M, Braido, F, Buhl, R, Bumbacea, R S, Bush, A, Calderon, M, Calvo-Gil, M, Camargos, P, Caraballo, L, Cardona, V, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, A M, Chandrasekharan, R, Charpin, D, Chen, Y Z, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Christoff, G, Chu, D K, Cingi, C, Correia de Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, Z A, Emuzyte, R, Fiocchi, A, Fyhrquist, N, Gomez, R M, Gotua, M, Guzman, M A, Hagemann, J, Hamamah, S, Halken, S, Halpin, D M G, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, A F, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Grutta, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Martinez-Infante, E, Matricardi, P, Miculinic, N, Migueres, N, Mihaltan, F, Mohammad, Y, Moniuszko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Park, H S, Pitsios, C, Plavec, D, Popov, T A, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, M S, Robalo Cordeiro, C, Roche, N, Rodriguez-Gonzalez, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Serpa, F S, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, J C, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Tomazic, P V, Urrutia-Pereira, M, Valentin-Rostan, M, Van Ganse, E, van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, D Y, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, J A, Zuberbier, T, and Anto, J M
- Abstract
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases., Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
- Published
- 2023
15. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
- Author
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Bousquet, J, Melén, E, Haahtela, T, Koppelman, G H, Togias, A, Valenta, R, Akdis, C A, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickmann, M, Aguilar, D, Akdis, M, Ansotegui, I J, Barbara, C, Bedbrook, A, Bindslev Jensen, C, Bosnic-Anticevich, S, Boulet, L P, Brightling, C E, Brussino, L, Burte, E, Bustamante, M, Canonica, G W, Cecchi, L, Celedon, J C, Chaves-Loureiro, C, Costa, E, Cruz, A A, Erhola, M, Gemicioglu, B, Fokkens, W J, Garcia Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, J C, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Lemonnier, N, Lodrup Carlsen, K C, Louis, R, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, R N, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, N G, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, F S, Ring, J, Rouadi, P W, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, M H, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, M J, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, M T, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, A H, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Arshad, H S, Asayag, E, Baharudin, A, Battur, L, Bennoor, K S, Berghea, E C, Bergmann, K C, Bernstein, D, Bewick, Michael, Blain, H, Bonini, M, Braido, F, Buhl, R, Bumbacea, R, Bush, A, Calderon, M, Calvo, G, Camargos, P, Caraballo, L, Cardona, V, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, A M, Chandrasekharan, R, Charpin, D, Chen, Y Z, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Christoff, G, Chu, D K, Cingi, C, Correia da Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, Z A, Emuzyte, R, Fiocchi, A, Fyhrquist, N, Gomez, R M, Gotua, M, Guzman, M A, Hagemann, J, Hamamah, S, Halken, S, Halpin, D M G, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, O, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Gruta, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Mäkelä, M J, Martinez-Infante, E, Matricardi, P, Miculinic, N, Migueres, N, Mihaltan, F, Mohamad, Y, Moniusko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R E, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Park, H S, Pitsios, C, Plavec, D, Popov, T A, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, R, Roballo-Cordeiro, C, Roche, N, Rodriguez-Gonzales, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Sarquis-Serpa, F, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, J C, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Tomazic, P V, Urrutia-Pereira, M, Valentin-Rostan, M, van Ganse, E, Van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, D Y, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, J A, Zuberbier, T, Anto, J M, Bousquet, J, Melén, E, Haahtela, T, Koppelman, G H, Togias, A, Valenta, R, Akdis, C A, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickmann, M, Aguilar, D, Akdis, M, Ansotegui, I J, Barbara, C, Bedbrook, A, Bindslev Jensen, C, Bosnic-Anticevich, S, Boulet, L P, Brightling, C E, Brussino, L, Burte, E, Bustamante, M, Canonica, G W, Cecchi, L, Celedon, J C, Chaves-Loureiro, C, Costa, E, Cruz, A A, Erhola, M, Gemicioglu, B, Fokkens, W J, Garcia Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, J C, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Lemonnier, N, Lodrup Carlsen, K C, Louis, R, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, R N, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, N G, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, F S, Ring, J, Rouadi, P W, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, M H, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, M J, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, M T, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, A H, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Arshad, H S, Asayag, E, Baharudin, A, Battur, L, Bennoor, K S, Berghea, E C, Bergmann, K C, Bernstein, D, Bewick, Michael, Blain, H, Bonini, M, Braido, F, Buhl, R, Bumbacea, R, Bush, A, Calderon, M, Calvo, G, Camargos, P, Caraballo, L, Cardona, V, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, A M, Chandrasekharan, R, Charpin, D, Chen, Y Z, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Christoff, G, Chu, D K, Cingi, C, Correia da Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, Z A, Emuzyte, R, Fiocchi, A, Fyhrquist, N, Gomez, R M, Gotua, M, Guzman, M A, Hagemann, J, Hamamah, S, Halken, S, Halpin, D M G, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, O, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Gruta, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Mäkelä, M J, Martinez-Infante, E, Matricardi, P, Miculinic, N, Migueres, N, Mihaltan, F, Mohamad, Y, Moniusko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R E, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Park, H S, Pitsios, C, Plavec, D, Popov, T A, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, R, Roballo-Cordeiro, C, Roche, N, Rodriguez-Gonzales, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Sarquis-Serpa, F, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, J C, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Tomazic, P V, Urrutia-Pereira, M, Valentin-Rostan, M, van Ganse, E, Van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, D Y, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, J A, Zuberbier, T, and Anto, J M
- Abstract
Asthma, rhinitis and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease", coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitisation and multimorbidity, (iii) advances in mHealth for novel phenotype definition, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis". This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitisation patterns (mono- or pauci-sensitisation versus polysensitisation), (iii) severity of symptoms and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and auto-immune diseases. [Abstract copyright: This article is protected by copyright. All rights reserved.]
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- 2023
16. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
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Bousquet, J; https://orcid.org/0000-0002-4061-4766, Melén, E; https://orcid.org/0000-0002-8248-0663, Haahtela, T; https://orcid.org/0000-0003-4757-2156, Koppelman, G H; https://orcid.org/0000-0001-8567-3252, Togias, A; https://orcid.org/0000-0001-9009-5717, Valenta, R; https://orcid.org/0000-0001-5944-3365, Akdis, C A; https://orcid.org/0000-0001-8020-019X, Czarlewski, W; https://orcid.org/0000-0002-6180-3232, Rothenberg, M; https://orcid.org/0000-0001-9790-6332, Valiulis, A; https://orcid.org/0000-0002-0287-9915, Wickman, M; https://orcid.org/0000-0003-2710-8620, Akdis, M; https://orcid.org/0000-0003-0554-9943, Aguilar, D; https://orcid.org/0000-0001-5399-3278, Bedbrook, A; https://orcid.org/0000-0001-9226-7762, Bindslev‐Jensen, C; https://orcid.org/0000-0002-8940-038X, Bosnic‐Anticevich, S; https://orcid.org/0000-0001-5077-8329, Boulet, L P; https://orcid.org/0000-0003-3485-9393, Brightling, C E; https://orcid.org/0000-0002-9345-4903, Brussino, L; https://orcid.org/0000-0001-7249-7616, Burte, E; https://orcid.org/0000-0003-3341-5352, Bustamante, M; https://orcid.org/0000-0003-0127-2860, Canonica, G W; https://orcid.org/0000-0001-8467-2557, Cecchi, L; https://orcid.org/0000-0002-0658-2449, Celedon, J C; https://orcid.org/0000-0001-7676-4478, Chaves Loureiro, C; https://orcid.org/0000-0003-0438-6126, Costa, E; https://orcid.org/0000-0003-1158-1480, Cruz, A A; https://orcid.org/0000-0002-7403-3871, Erhola, M; https://orcid.org/0000-0002-1364-9023, Gemicioglu, B; https://orcid.org/0000-0001-5953-4881, Fokkens, W J; https://orcid.org/0000-0003-4852-229X, et al, Schmid-Grendelmeier, P; https://orcid.org/0000-0003-3215-3370, Bousquet, J; https://orcid.org/0000-0002-4061-4766, Melén, E; https://orcid.org/0000-0002-8248-0663, Haahtela, T; https://orcid.org/0000-0003-4757-2156, Koppelman, G H; https://orcid.org/0000-0001-8567-3252, Togias, A; https://orcid.org/0000-0001-9009-5717, Valenta, R; https://orcid.org/0000-0001-5944-3365, Akdis, C A; https://orcid.org/0000-0001-8020-019X, Czarlewski, W; https://orcid.org/0000-0002-6180-3232, Rothenberg, M; https://orcid.org/0000-0001-9790-6332, Valiulis, A; https://orcid.org/0000-0002-0287-9915, Wickman, M; https://orcid.org/0000-0003-2710-8620, Akdis, M; https://orcid.org/0000-0003-0554-9943, Aguilar, D; https://orcid.org/0000-0001-5399-3278, Bedbrook, A; https://orcid.org/0000-0001-9226-7762, Bindslev‐Jensen, C; https://orcid.org/0000-0002-8940-038X, Bosnic‐Anticevich, S; https://orcid.org/0000-0001-5077-8329, Boulet, L P; https://orcid.org/0000-0003-3485-9393, Brightling, C E; https://orcid.org/0000-0002-9345-4903, Brussino, L; https://orcid.org/0000-0001-7249-7616, Burte, E; https://orcid.org/0000-0003-3341-5352, Bustamante, M; https://orcid.org/0000-0003-0127-2860, Canonica, G W; https://orcid.org/0000-0001-8467-2557, Cecchi, L; https://orcid.org/0000-0002-0658-2449, Celedon, J C; https://orcid.org/0000-0001-7676-4478, Chaves Loureiro, C; https://orcid.org/0000-0003-0438-6126, Costa, E; https://orcid.org/0000-0003-1158-1480, Cruz, A A; https://orcid.org/0000-0002-7403-3871, Erhola, M; https://orcid.org/0000-0002-1364-9023, Gemicioglu, B; https://orcid.org/0000-0001-5953-4881, Fokkens, W J; https://orcid.org/0000-0003-4852-229X, et al, and Schmid-Grendelmeier, P; https://orcid.org/0000-0003-3215-3370
- Abstract
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper‐ and lower‐airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one‐airway‐one‐disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll‐Like Receptors and IL‐17 for rhinitis alone as a local disease; IL‐33 and IL‐5 for allergic and non‐allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono‐ or pauci‐sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
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- 2023
17. Analyse de l’utilisation régulière des CSI/LABA dans l’asthme modéré à sévère chez les médecins : études sur les perspectives des médecins et des patients asthmatiques sur le fardeau et la prise en charge de l’asthme (résultats des études APPaRENT 1 et 2)
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Chapman, K., primary, Bosnic-Anticevich, S., additional, Cano, M.C., additional, Besème, C., additional, and Pg, A., additional
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- 2023
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18. The ARIA-MeDALL hypothesis
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Bousquet, J, Melén, E, Haahtela, T, Koppelman, G H, Togias, A, Valenta, R, Akdis, C A, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickmann, M, Bonini, M, Braido, F, Buhl, R, Bumbacea, R, Bush, A, Calderon, M, Calvo, G, Camargos, P, Caraballo, L, Cardona, V, Aguilar, D, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, A M, Chandrasekharan, R, Charpin, D, Chen, Y Z, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Akdis, M, Christoff, G, Chu, D K, Cingi, C, Correia da Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Ansotegui, I J, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, Z A, Emuzyte, R, Barbara, C, Fiocchi, A, Fyhrquist, N, Gomez, R M, Gotua, M, Guzman, M A, Hagemann, J, Hamamah, S, Halken, S, Halpin, D M G, Bedbrook, A, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Bindslev Jensen, C, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, O, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Gruta, S, Bosnic-Anticevich, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Mäkelä, M J, Martinez-Infante, E, Matricardi, P, Miculinic, N, Boulet, L P, Migueres, N, Mihaltan, F, Mohamad, Y, Moniusko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R E, Brightling, C E, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Brussino, L, Park, H S, Pitsios, C, Plavec, D, Popov, T A, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, R, Roballo-Cordeiro, C, Roche, N, Burte, E, Rodriguez-Gonzales, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Sarquis-Serpa, F, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, J C, Bustamante, M, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Canonica, G W, Tomazic, P V, Urrutia-Pereira, M, Valentin-Rostan, M, van Ganse, E, Van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, D Y, Cecchi, L, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, J A, Celedon, J C, Zuberbier, T, Anto, J M, Chaves-Loureiro, C, Costa, E, Cruz, A A, Erhola, M, Gemicioglu, B, Fokkens, W J, Garcia Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, J C, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Lemonnier, N, Lodrup Carlsen, K C, Louis, R, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, R N, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, N G, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, F S, Ring, J, Rouadi, P W, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, M H, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, M J, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, M T, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, A H, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Arshad, H S, Asayag, E, Baharudin, A, Battur, L, Bennoor, K S, Berghea, E C, Bergmann, K C, Bernstein, D, Bewick, M, Blain, H, UCIBIO - Applied Molecular Biosciences Unit, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
- Subjects
SDG 3 - Good Health and Well-being - Abstract
Asthma, rhinitis and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease", coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitisation and multimorbidity, (iii) advances in mHealth for novel phenotype definition, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis". This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitisation patterns (mono- or pauci-sensitisation versus polysensitisation), (iii) severity of symptoms and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and auto-immune diseases. authorsversion epub_ahead_of_print
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- 2023
19. The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes [Corrigendum]
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Bosnic-Anticevich S, Chrystyn H, Costello R, Dolovich MB, Fletcher M, Lavorini F, Rodríguez-Roisin R, Ryan D, Wan Yau Ming S, and Price DB
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Diseases of the respiratory system ,RC705-779 - Abstract
Bosnic-Anticevich S, Chrystyn H, Costello RW, et al. Int J Chron Obstruct Pulmon Dis. 2017;12:59–71. Upon reviewing the article, the authors noticed an error in Figure 2 (page 65). The position of the markers for the incidence rate ratio for moderate/severe exacerbations and the odds ratio for average daily SABA dose (OR) in the initial figure were switched. The authors apologize for this error and have corrected the positions of both markers. The authors confirm that the values for both results in the figure legend and the corresponding text are correct and that the conclusion derived from this figure and the overall article do not change. Read the original article
- Published
- 2019
20. Real-life biomarker response to anti-IL5 and anti-IgE therapies in severe asthma patients
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Burkill, S, primary, M. Porsbjerg, C, additional, Bourdin, A, additional, N Tran, T, additional, Martin, N, additional, Katial, R, additional, Barker, P, additional, E Wechsler, M, additional, Maspero, J, additional, Bosnic-Anticevich, S, additional, Chung, L P, additional, Katsoulotos, G, additional, C Christoff, G, additional, A Popov, T, additional, Sadatsafavi, M, additional, A Torres-Duque, C, additional, Ulrik, C, additional, Dahl Assing, K, additional, Hansen, S, additional, Altraja, A, additional, A Lehtimaki, L, additional, G Papadopoulos, N, additional, Kostikas, K, additional, Salvi, S, additional, W Costello, R, additional, Francesca, P, additional, Iwanaga, T, additional, Rhee, C K, additional, Al-Ahmad, M, additional, Larenas-Linnemann, D, additional, A Fonseca, J, additional, Amaral, R, additional, Alving, K, additional, Al-Lehebi, R, additional, Perez De-Llano, L, additional, Kirenga, B, additional, Tsai, M, additional, Mahboub, B, additional, E Pfeffer, P, additional, Henley, W, additional, Liu, Y, additional, Lyu, J, additional, Goh, C, additional, Uthaman, T, additional, Price, D, additional, and Townend, J, additional
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- 2022
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21. Sufficient inspiratory effort for a Dry Powder Inhaler - do we have to measure it, or can we observe it? Post hoc analysis of the PIFotal study
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Leving, M, primary, Bosnic-Anticevich, S, additional, Van Cooten, J, additional, Correia De Sousa, J, additional, Cvetkovski, B, additional, Dekhuijzen, R, additional, Dijk, L, additional, Garcia Pardo, M, additional, Gardev, A, additional, Gawlik, R, additional, Van Der Ham, I, additional, Jansen, Y, additional, Lavorini, F, additional, Maricoto, T, additional, Meijer, J, additional, Metz, B, additional, Price, D, additional, Roman Rodriguez, M, additional, Schuttel, K, additional, Stoker, N, additional, Tsiligianni, I, additional, Usmani, O, additional, and Kocks, J, additional
- Published
- 2022
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22. The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study
- Author
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Bousquet, J., Arnavielhe, S., Bedbrook, A., Fonseca, J., Morais Almeida, M., Todo Bom, A., Annesi‐Maesano, I., Caimmi, D., Demoly, P., Devillier, P., Siroux, V., Menditto, E., Passalacqua, G., Stellato, C., Ventura, M. T., Cruz, A. A., Sarquis Serpa, F., da Silva, J., Larenas‐Linnemann, D., Rodriguez Gonzalez, M., Burguete Cabañas, M. T., Bergmann, K. C., Keil, T., Klimek, L., Mösges, R., Shamai, S., Zuberbier, T., Bewick, M., Price, D., Ryan, D., Sheikh, A., Anto, J. M., Mullol, J., Valero, A., Haahtela, T., Valovirta, E., Fokkens, W. J., Kuna, P., Samolinski, B., Bindslev‐Jensen, C., Eller, E., Bosnic‐Anticevich, S., OʼHehir, R. E., Tomazic, P. V., Yorgancioglu, A., Gemicioglu, B., Bachert, C., Hellings, P. W., Kull, I., Melén, E., Wickman, M., van Eerd, M., and De Vries, G.
- Published
- 2018
- Full Text
- View/download PDF
23. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA‐ARIA) ‐ EIP on AHA Twinning Reference Site (GARD research demonstration project)
- Author
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Bousquet, J., Agache, I., Aliberti, M. R., Angles, R., Annesi‐Maesano, I., Anto, J. M., Arnavielhe, S., Asayag, E., Bacci, E., Bedbrook, A., Bachert, C., Baroni, I., Barreto, B. A., Bedolla‐Barajas, M., Bergmann, K. C., Bertorello, L., Bewick, M., Bieber, T., Birov, S., Bindslev‐Jensen, C., Blua, A., Bochenska Marciniak, M., Bogus‐Buczynska, I., Bosnic‐Anticevich, S., Bosse, I., Bourret, R., Bucca, C., Buonaiuto, R., Burguete Cabanas, M. T., Caillaud, D., Caimmi, D. P., Caiazza, D., Camargos, P., Canfora, G., Cardona, V., Carriazo, A. M., Cartier, C., Castellano, G., Chavannes, N. H., Cecci, L., Ciaravolo, M. M., Cingi, C., Ciceran, A., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés‐Grimaldo, R. M., Corti, F., Costa, E., Courbis, A. L., Cousein, E., Cruz, A. A., Custovic, A., Cvetkovski, B., Dario, C., da Silva, J., Dauvilliers, Y., De Blay, F., Dedeu, T., De Feo, G., De Martino, B., Demoly, P., De Vries, G., Di Capua Ercolano, S., Di Carluccio, N., Doulapsi, M., Dray, G., Dubakiene, R., Eller, E., Emuzyte, R., Espinoza‐Contreras, J. G., Estrada‐Cardona, A., Farrell, J., Farsi, A., Ferrero, J., Fokkens, W. J., Fonseca, J., Fontaine, J. F., Forti, S., Gálvez‐Romero, J. L., García‐Cobas, C. I., Garcia Cruz, M. H., Gemicioğlu, B., Gerth van Wijk, R., Guidacci, M., Gómez‐Vera, J., Guldemond, N. A., Gutter, Z., Haahtela, T., Hajjam, J., Hellings, P. W., Hernández‐Velázquez, L., Illario, M., Ivancevich, J. C., Jares, E., Joos, G., Just, J., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Keil, T., Khaltaev, N., Klimek, L., Kritikos, V., Kull, I., Kuna, P., Kvedariene, V., Kolek, V., Krzych‐Fałta, E., Kupczyk, M., Lacwik, P., La Grutta, S., Larenas‐Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Lessa, M., Levato, G., Lewis, L., Lieten, I., Lipiec, A., Louis, R., Luna‐Pech, J. A., Magnan, A., Malva, J., Maspero, J. F., Matta‐Campos, J. J., Mayora, O., Medina‐Ávalos, M. A., Melén, E., Menditto, E., Millot‐Keurinck, J., Moda, G., Morais‐Almeida, M., Mösges, R., Mota‐Pinto, A., Mullol, J., Muraro, A., Murray, R., Noguès, M., Nalin, M., Napoli, L., Neffen, H., OʼHehir, R. E., Onorato, G. L., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Pozzi, A. C., Prokopakis, E., Pugin, B., Raciborski, F., Rimmer, J., Rizzo, J. A., Robalo‐Cordeiro, C., Rodríguez‐González, M., Rolla, G., Roller‐Wirnsberger, R. E., Romano, A., Romano, M., Romano, M. R., Salimäki, J., Samolinski, B., Serpa, F. S., Shamai, S., Sierra, M., Sova, M., Sorlini, M., Stellato, C., Stelmach, R., Strandberg, T., Stroetmann, V., Stukas, R., Szylling, A., Tan, R., Tibaldi, V., Todo‐Bom, A., Toppila‐Salmi, S., Tomazic, P., Trama, U., Triggiani, M., Valero, A., Valovirta, E., Valiulis, A., van Eerd, M., Vasankari, T., Vatrella, A., Ventura, M. T., Verissimo, M. T., Viart, F., Williams, S., Wagenmann, M., Wanscher, C., Westman, M., Wickman, M., Young, I., Yorgancioglu, A., Zernotti, E., Zuberbier, T., Zurkuhlen, A., De Oliviera, B., and Senn, A.
- Published
- 2018
- Full Text
- View/download PDF
24. Inhaler competence in asthma: Common errors, barriers to use and recommended solutions
- Author
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Price, D., Bosnic-Anticevich, S., Briggs, A., Chrystyn, H., Rand, C., Scheuch, G., and Bousquet, J.
- Published
- 2013
- Full Text
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25. Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Bousquet J., Anto J. M., Iaccarino G., Czarlewski W., Haahtela T., Anto A., Akdis C. A., Blain H., Canonica G. W., Cardona V., Cruz A. A., Illario M., Ivancevich J. C., Jutel M., Klimek L., Kuna P., Laune D., Larenas-Linnemann D., Mullol J., Papadopoulos N. G., Pfaar O., Samolinski B., Valiulis A., Yorgancioglu A., Zuberbier T., Abdul Latiff A. H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis C., Akdis M., Al-Ahmad M., Al-Zahab Bassam A., Aldrey-Palacios O., Alvarez Cuesta E., Alzaabi A., Amad S., Ambrocio G., Annesi-Maesano I., Ansotegui I., Anto J., Arshad H., Artesani M. C., Asayag E., Avolio F., Azhari K., Baiardini I., Bajrovic N., Bakakos P., Bakeyala Mongono S., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Bateman E. D., Battur L., Bedbrook A., Bedolla Barajas M., Beghe B., Bel E., Ben Kheder A., Benson M., Berghea C., Bergmann K. -C., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N., Bilo M. B., Bindslev-Jensen C., Bjermer L., Bochenska Marciniak M., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L. -P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C., Brozek J., Buhl R., Bumbacea R., Burguete Cabanas M. T., Bush A., Busse W. W., Buters J., Caballero-Fonseca F., Calderon M. A., Calvo M., Camargos P., Camuzat T., Cano A., Capriles-Hulett A., Caraballo L., Carlsen K. -H., Caro J., Carr W., Carreon-Asuncion F., Carriazo A. M., Casale T., Castor M. A., Castro E., Cecchi L., Cepeda Sarabia A., Chandrasekharan R., Chang Y. -S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N. H., Chen Y., Cheng L., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D. K., Chua A., Chuchalin A., Chung K. F., Ciceran A., Cingi C., Ciprandi G., Cirule I., Coelho A. C., Constantinidis J., Correia De Sousa J., Costa E., Costa D., Costa Dominguez M. D. C., Coste A., Cox L., Cullen J., Custovic A., Cvetkovski B., D'Amato G., Da Silva J., Dahl R., Dahlen S. -E., Daniilidis V., Darjazini Nahhas L., Darsow U., De Blay F., De Guia E., De Los Santos C., De Manuel Keenoy E., De Vries G., Deleanu D., Demoly P., Denburg J., Devillier P., Didier A., Dimou M., Dinh-Xuan A. T., Djukanovic R., Dokic D., Dominguez Silva M. G., Douagui H., Douladiris N., Doulaptsi M., Dray G., Dubakiene R., Durham S., Dykewicz M., Ebo D., Edelbaher N., Eklund P., El-Gamal Y., El-Sayed Z. A., El-Sayed S. S., El-Seify M., Emuzyte R., Enecilla L., Espinoza H., Espinoza Contreras J. G., Farrell J., Fernandez L., Fink Wagner A., Fiocchi A., Fokkens W. J., Fontaine J. -F., Forastiere F., Fuentes Perez J. M., Gaerlan-Resureccion E., Gaga M., Galvez Romero J. L., Gamkrelidze A., Garcia A., Garcia Cobas C. Y., Garcia Cruz M. D. L. L. H., Gayraud J., Gemicioglu B., Genova S., Gereda J., Gerth Van Wijk R., Gomez M., Gonzalez Diaz S., Gotua M., Grigoreas C., Grisle I., Guidacci M., Guldemond N., Gutter Z., Guzman A., Halloum R., Hamelmann E., Hammadi S., Harvey R., Heinrich J., Hejjaoui A., Hellquist-Dahl B., Hernandez Velazquez L., Hew M., Hossny E., Howarth P., Hrubisko M., Huerta Villalobos Y. R., Humbert M., Hyland M., Ibrahim M., Ilyina N., Irani C., Ispayeva Z., Jares E., Jarvis D., Jassem E., Jenko K., Jimeneracruz Uscanga R. D., Johnston S., Joos G., Jost M., Julge K., Jung K. -S., Just J., Kaidashev I., Kalayci O., Kalyoncu F., Kapsali J., Kardas P., Karjalainen J., Kasala C. A., Katotomichelakis M., Kazi B., Keil T., Keith P., Khaitov M., Khaltaev N., Kim Y. -Y., Kleine-Tebbe J., Koffi N'Goran B., Kompoti E., Kopac P., Koppelman G., Koren Jeverica A., Kosnik M., Kostov K. V., Kowalski M. L., Kralimarkova T., Kramer Vrscaj K., Kraxner H., Kreft S., Kritikos V., Kudlay D., Kull I., Kupczyk M., Kvedariene V., Kyriakakou M., Lalek N., Lane S., Latiff A., Lau S., Lavrut J., Le L., Lessa M., Levin M., Li J., Lieberman P., Liotta G., Lipworth B., Liu X., Lobo R., Lodrup Carlsen K. C., Lombardi C., Louis R., Loukidis S., Lourenco O., Luna Pech J. A., Madjar B., Magnan A., Mahboub B., Mair A., Mais Y., Maitland Van Der Zee A. -H., Makela M., Makris M., Malling H. -J., Mandajieva M., Manning P., Manousakis M., Maragoudakis P., Marshall G., Martinsmartins P., Masjedi M. R., Maspero J. F., Matta Campos J. J., Maurer M., Mavale-Manuel S., Meco C., Melen E., Melo-Gomes E., Meltzer E. O., Menditto E., Menzies-Gow A., Merk H., Michel J. -P., Miculinic N., Midao L., Mihaltan F., Mikael K., Mikos N., Milenkovic B., Mitsias D., Moalla B., Moda G., Mogica Martinez M. D., Mohammad Y., Moin M., Molimard M., Momas I., Monaco A., Montefort S., Mora D., Morais-Almeida M., Mosges R., Mostafa B. E., Munter L., Muraro A., Murray R., Mustakov T., Naclerio R., Nadif R., Nakonechna A., Namazova-Baranova L., Navarro-Locsin G., Neffen H., Nekam K., Neou A., Nicod L., Niederberger-Leppin V., Niedoszytko M., Nieto A., Novellino E., Nunes E., Nyembue D., O'Hehir R., Odjakova C., Ohta K., Okamoto Y., Okubo K., Oliver B., Onorato G. L., Orru M. P., Ouedraogo S., Ouoba K., Paggiaro P. L., Pagkalos A., Palaniappan S. P., Pali-Scholl I., Palkonen S., Palmer S., Panaitescu Bunu C., Panzner P., Papanikolaou V., Papi A., Paralchev B., Paraskevopoulos G., Park H. S., Passalacqua G., Patella V., Pavord I., Pawankar R., Pedersen S., Peleve S., Pereira A., Perez T., Pham-Thi N., Pigearias B., Pin I., Piskou K., Pitsios C., Pitsios K., Plavec D., Poethig D., Pohl W., Poplas Susic A., Popov T. A., Portejoie F., Potter P., Poulsen L., Prados-Torres A., Prarros F., Price D., Prokopakis E., Puy R., Rabe K., Raciborski F., Ramos J., Recto M. T., Reda S. M., Regateiro F., Reider N., Reitsma S., Repka-Ramirez S., Rimmer J., Rivero Yeverino D., Rizzo J. A., Robalo-Cordeiro C., Roberts G., Roche N., Rodriguez Gonzalez M., Rodriguez Zagal E., Rolland C., Roller-Wirnsberger R., Roman Rodriguez M., Romano A., Rombaux P., Romualdez J., Rosado-Pinto J., Rosario N., Rosenwasser L., Rottem M., Rouadi P., Rovina N., Rozman Sinur I., Ruiz M., Ruiz Segura L. T., Ryan D., Sagara H., Sakai D., Sakurai D., Saleh W., Salimaki J., Salina H., Samitas K., Sanchez Coronel M. G., Sanchez-Borges M., Sanchez-Lopez J., Sarafoleanu C., Sarquis Serpa F., Sastre-Dominguez J., Scadding G., Scheire S., Schmid-Grendelmeier P., Schuhl J. F., Schunemann H., Schvalbova M., Scichilone N., Sepulveda C., Serrano E., Sheikh A., Shields M., Shishkov V., Siafakas N., Simeonov A., Simons E. F., Sisul J. C., Sitkauskiene B., Skrindo I., Soklic Kosak T., Sole D., Sooronbaev T., Soto-Martinez M., Sova M., Spertini F., Spranger O., Stamataki S., Stefanaki L., Stellato C., Stelmach R., Sterk P., Strandberg T., Stute P., Subramaniam A., Suppli Ulrik C., Sutherland M., Sylvestre S., Syrigou A., Taborda Barata L., Takovska N., Tan R., Tan F., Tan V., Tang I. P., Taniguchi M., Tannert L., Tattersall J., Teixeira M. D. C., Thijs C., Thomas M., To T., Todo-Bom A. M., Togias A., Tomazic P. -V., Toppila-Salmi S., Toskala E., Triggiani M., Triller N., Triller K., Tsiligianni I., Ulmeanu R., Urbancic J., Urrutia Pereira M., Vachova M., Valdes F., Valenta R., Valentin Rostan M., Valero A., Vallianatou M., Valovirta E., Van Eerd M., Van Ganse E., Van Hage M., Vandenplas O., Vasankari T., Vassileva D., Ventura M. T., Vera-Munoz C., Vicheva D., Vichyanond P., Vidgren P., Viegi G., Vogelmeier C., Von Hertzen L., Vontetsianos T., Vourdas D., Wagenmann M., Walker S., Wallace D., Wang D. Y., Waserman S., Wickman M., Williams S., Williams D., Wilson N., Woo K., Wright J., Wroczynski P., Xepapadaki P., Yakovliev P., Yamaguchi M., Yan K., Yap Y. Y., Yawn B., Yiallouros P., Yoshihara S., Young I., Yusuf O. B., Zaidi A., Zaitoun F., Zar H., Zernotti M., Zhang L., Zhong N., Zidarn M., Zubrinich C., UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Bousquet J., Anto J.M., Iaccarino G., Czarlewski W., Haahtela T., Anto A., Akdis C.A., Blain H., Canonica G.W., Cardona V., Cruz A.A., Illario M., Ivancevich J.C., Jutel M., Klimek L., Kuna P., Laune D., Larenas-linnemann D., Mullol J., Papadopoulos N.G., Pfaar O., Samolinski B., Valiulis A., Yorgancioglu A., Zuberbier T., Abdul Latiff A.H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis C., Akdis M., Al-Ahmad M., Bassam A.A.-Z., Aldrey-Palacios O., Cuesta E.A., Alzaabi A., Amad S., Ambrocio G., Annesi-Maesano I., Ansotegui I., Anto J., Arshad H., Artesani M.C., Asayag E., Avolio F., Azhari K., Baiardini I., Bajrovic N., Bakakos P., Mongono S.B., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Bateman E.D., Battur L., Bedbrook A., Barajas M.B., Beghe B., Bel E., Kheder A.B., Benson M., Berghea C., Bergmann K.-C., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N., Bilo M.B., Bindslev-Jensen C., Bjermer L., Marciniak M.B., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L.-P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C., Brozek J., Buhl R., Bumbacea R., Cabanas M.T.B., Bush A., Busse W.W., Buters J., Caballero-Fonseca F., Calderon M.A., Calvo M., Camargos P., Camuzat T., Cano A., Capriles-Hulett A., Caraballo L., Carlsen K.-H., Caro J., Carr W., Carreon-Asun-cion F., Carriazo A.M., Casale T., Castor M.A., Castro E., Cecchi L., Sarabia A.C., Chandrasekharan R., Chang Y.-S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N.H., Chen Y., Cheng L., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D.K., Chua A., Chuchalin A., Chung K.F., Ciceran A., Cingi C., Ciprandi G., Cirule I., Coelho A.C., Constantinidis J., de Sousa J.C., Costa E., Costa D., Dominguez M.C.C., Coste A., Cox L., Cullen J., Custovic A., Cvetkovski B., D'amato G., Silva J.D., Dahl R., Dahlen S.-E., Daniilidis V., Nahhas L.D., Darsow U., Blay F., Guia E.D., Santos C., Keenoy E.D.M., Vries G.D., Deleanu D., Demoly P., Denburg J., Devillier P., Didier A., Dimou M., Dinh-Xuan A.T., Djukanovic R., Dokic D., Dominguez Silva M.G., Douagui H., Douladiris N., Doulaptsi M., Dray G., Dubakiene R., Durham S., Dykewicz M., Ebo D., Edelbaher N., Eklund P., El-Gamal Y., El-Sayed Z.A., El-Sayed S.S., El-Seify M., Emuzyte R., Enecilla L., Espinoza H., Guillermo J., Contreras E., Farrell J., Fernandez L., Wagner A.F., Fiocchi A., Fokkens W.J., Fontaine J.-F., Forastiere F., Perez J.M.F., Gaerlan-resureccion E., Gaga M., Romero J.L.G., Gamkrelidze A., Garcia A., Cobas C.Y.G., Garcia Cruz M.L.L.H., Gayraud J., Gemicioglu B., Genova S., Gereda J., Wijk R.G., Gomez M., Diaz S.G., Gotua M., Grigoreas C., Grisle I., Guidacci M., Guldemond N., Gutter Z., Guzman A., Halloum R., Hamelmann E., Hammadi S., Harvey R., Heinrich J., Hejjaoui A., Hellquist-Dahl B., Velazquez L.H., Hew M., Hossny E., Howarth P., Hrubisko M., Villalobos Y.R.H., Humbert M., Hyland M., Ibrahim M., Ilyina N., Irani C., Ispayeva Z., Jares E., Jarvis D., Jassem E., Jenko K., Uscanga R.D.J., Johnston S., Joos G., Jost M., Julge K., Jung K.-S., Just J., Kaidashev I., Kalayci O., Kalyoncu F., Kapsali J., Kardas P., Karjalainen J., Kasala C.A., Katotomichelakis M., Kazi B., Keil T., Keith P., Khaitov M., Khaltaev N., Kim Y.-Y., Kleine-Tebbe J., Koffi N'Goran B., Kompoti E., Kopac P., Koppelman G., Jeverica A.K., Kosnik M., Kostov K.V., Kowalski M.L., Kralimarkova T., Vrscaj K.K., Kraxner H., Kreft S., Kritikos V., Kudlay D., Kull I., Kupczyk M., Kvedariene V., Kyriakakou M., Lalek N., Lane S., Larenas-Linnemann D., Latiff A., Lau S., Lavrut J., Le L., Lessa M., Levin M., Li J., Lieberman P., Liotta G., Lipworth B., Liu X., Lobo R., Lodrup Carlsen K.C., Lombardi C., Louis R., Loukidis S., Lourenco O., Luna Pech J.A., Madjar B., Magnan A., Mahboub B., Mair A., Mais Y., van der Zee A.-H.M., Makela M., Makris M., Malling H.-J., Mandajieva M., Manning P., Manousakis M., Maragoudakis P., Marshall G., Martins P., Reza Masjedi M., Maspero J.F., Campos J.J.M., Maurer M., Mavale-Manuel S., Meco C., Melen E., Melo-Gomes E., Meltzer E.O., Menditto E., Menzies-Gow A., Merk H., Michel J.-P., Miculinic N., Midao L., Mihaltan F., Mikael K., Mikos N., Milenkovic B., Mitsias D., Moalla B., Moda G., Martinez M.D.M., Mohammad Y., Moin M., Molimard M., Momas I., Monaco A., Montefort S., Mora D., Morais-Almeida M., Mosges R., Mostafa B.E., Munter L., Muraro A., Murray R., Mustakov T., Naclerio R., Nadif R., Nakonechna A., Namazova-Baranova L., Navarro-Locsin G., Neffen H., Nekam K., Neou A., Nicod L., Niederberger-Leppin V., Niedoszytko M., Nieto A., Novellino E., Nunes E., Nyembue D., O'hehir R., Odjakova C., Ohta K., Okamoto Y., Okubo K., Oliver B., Onorato G.L., Orru M.P., Ouedraogo S., Ouoba K., Paggiaro P.L., Pagkalos A., Palaniappan S.P., Pali-Scholl I., Palkonen S., Palmer S., Bunu C.P., Panzner P., Papanikolaou V., Papi A., Paralchev B., Paraskevopoulos G., Park H.S., Passalacqua G., Patella V., Pavord I., Pawankar R., Pedersen S., Peleve S., Pereira A., Perez T., Pham-Thi N., Pigearias B., Pin I., Piskou K., Pitsios C., Pitsios K., Plavec D., Poethig D., Pohl W., Susic A.P., Popov T.A., Portejoie F., Potter P., Poulsen L., Prados-Torres A., Prarros F., Price D., Prokopakis E., Puy R., Rabe K., Raciborski F., Ramos J., Recto M.T., Reda S.M., Regateiro F., Reider N., Reitsma S., Repka-Ramirez S., Rimmer J., Yeverino D.R., Rizzo J.A., Robalo-Cordeiro C., Roberts G., Roche N., Gonzalez M.R., Zagal E.R., Rolland C., Roller-Wirns-berger R., Rodriguez M.R., Romano A., Rombaux P., Romualdez J., Rosado-Pinto J., Rosario N., Rosenwasser L., Rottem M., Rouadi P., Rovina N., Sinur I.R., Ruiz M., Segura L.T.R., Ryan D., Sagara H., Sakai D., Sakurai D., Saleh W., Salimaki J., Salina H., Samitas K.-N., Coronel M.G.S., Sanchez-Borges M., Sanchez-Lopez J., Sarafoleanu C., Serpa F.S., Sastre-Dominguez J., Scadding G., Scheire S., Schmid-Grendelmeier P., Schuhl J.F., Schunemann H., Schvalbova M., Scichilone N., Sepulveda C., Serrano E., Sheikh A., Shields M., Shishkov V., Siafakas N., Simeonov A., Simons E.F., Sisul J.C., Sitkauskiene B., Skrindo I., Kosak T.S., Sole D., Sooronbaev T., Soto-Martinez M., Sova M., Spertini F., Spranger O., Stamataki S., Stefanaki L., Stellato C., Stelmach R., Sterk P., Strandberg T., Stute P., Subramaniam A., Suppli Ulrik C., Sutherland M., Sylvestre S., Syrigou A., Barata L.T., Takovska N., Tan R., Tan F., Tan V., Tang I.P., Taniguchi M., Tannert L., Tattersall J., Teixeira M.D.C., Thijs C., Thomas M., To T., Todo-Bom A.M., Togias A., Tomazic P.-V., Toppila-Salmi S., Toskala E., Triggiani M., Triller N., Triller K., Tsiligianni I., Ulmeanu R., Urbancic J., Pereira M.U., Vachova M., Valdes F., Valenta R., Rostan M.V., Valero A., Vallianatou M., Valovirta E., Eerd M.V., Ganse E.V., Hage M., Vandenplas O., Vasankari T., Vassileva D., Ventura T., Vera-Munoz C., Vicheva D., Vichyanond P., Vidgren P., Viegi G., Vogelmeier C., Hertzen L.V., Vontetsianos T., Vourdas D., Wagenmann M., Walker S., Wallace D., Wang D.Y., Waserman S., Wickman M., Williams S., Williams D., Wilson N., Woo K., Wright J., Wroczynski P., Xepapadaki P., Yakovliev P., Yamaguchi M., Yan K., Yap Y.Y., Yawn B., Yiallouros P., Yoshihara S., Young I., Yusuf O.B., Zaidi A., Zaitoun F., Zar H., Zernotti M., Zhang L., Zhong N., Zidarn M., Zubrinich C., Dubakienė, Rūta, Ėmužytė, Regina, Kvedarienė, Violeta, Bousquet, J., Anto, J. M., Iaccarino, G., Czarlewski, W., Haahtela, T., Anto, A., Akdis, C. A., Blain, H., Canonica, G. W., Cardona, V., Cruz, A. A., Illario, M., Ivancevich, J. C., Jutel, M., Klimek, L., Kuna, P., Laune, D., Larenas-Linnemann, D., Mullol, J., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Abdul Latiff, A. H., Abdullah, B., Aberer, W., Abusada, N., Adcock, I., Afani, A., Agache, I., Aggelidis, X., Agustin, J., Akdis, C., Akdis, M., Al-Ahmad, M., Al-Zahab Bassam, A., Aldrey-Palacios, O., Alvarez Cuesta, E., Alzaabi, A., Amad, S., Ambrocio, G., Annesi-Maesano, I., Ansotegui, I., Anto, J., Arshad, H., Artesani, M. C., Asayag, E., Avolio, F., Azhari, K., Baiardini, I., Bajrovic, N., Bakakos, P., Bakeyala Mongono, S., Balotro-Torres, C., Barba, S., Barbara, C., Barbosa, E., Barreto, B., Bartra, J., Bateman, E. D., Battur, L., Bedbrook, A., Bedolla Barajas, M., Beghe, B., Bel, E., Ben Kheder, A., Benson, M., Berghea, C., Bergmann, K. -C., Bernstein, D., Bewick, M., Bialek, S., Bialoszewski, A., Bieber, T., Billo, N., Bilo, M. B., Bindslev-Jensen, C., Bjermer, L., Bochenska Marciniak, M., Bond, C., Boner, A., Bonini, M., Bonini, S., Bosnic-Anticevich, S., Bosse, I., Botskariova, S., Bouchard, J., Boulet, L. -P., Bourret, R., Bousquet, P., Braido, F., Briggs, A., Brightling, C., Brozek, J., Buhl, R., Bumbacea, R., Burguete Cabanas, M. T., Bush, A., Busse, W. W., Buters, J., Caballero-Fonseca, F., Calderon, M. A., Calvo, M., Camargos, P., Camuzat, T., Cano, A., Capriles-Hulett, A., Caraballo, L., Carlsen, K. -H., Caro, J., Carr, W., Carreon-Asuncion, F., Carriazo, A. M., Casale, T., Castor, M. A., Castro, E., Cecchi, L., Cepeda Sarabia, A., Chandrasekharan, R., Chang, Y. -S., Chato-Andeza, V., Chatzi, L., Chatzidaki, C., Chavannes, N. H., Chen, Y., Cheng, L., Chivato, T., Chkhartishvili, E., Christoff, G., Chrystyn, H., Chu, D. K., Chua, A., Chuchalin, A., Chung, K. F., Ciceran, A., Cingi, C., Ciprandi, G., Cirule, I., Coelho, A. C., Constantinidis, J., Correia De Sousa, J., Costa, E., Costa, D., Costa Dominguez, M. D. C., Coste, A., Cox, L., Cullen, J., Custovic, A., Cvetkovski, B., D'Amato, G., Da Silva, J., Dahl, R., Dahlen, S. -E., Daniilidis, V., Darjazini Nahhas, L., Darsow, U., De Blay, F., De Guia, E., De Los Santos, C., De Manuel Keenoy, E., De Vries, G., Deleanu, D., Demoly, P., Denburg, J., Devillier, P., Didier, A., Dimou, M., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Dominguez Silva, M. G., Douagui, H., Douladiris, N., Doulaptsi, M., Dray, G., Dubakiene, R., Durham, S., Dykewicz, M., Ebo, D., Edelbaher, N., Eklund, P., El-Gamal, Y., El-Sayed, Z. A., El-Sayed, S. S., El-Seify, M., Emuzyte, R., Enecilla, L., Espinoza, H., Espinoza Contreras, J. G., Farrell, J., Fernandez, L., Fink Wagner, A., Fiocchi, A., Fokkens, W. J., Fontaine, J. -F., Forastiere, F., Fuentes Perez, J. M., Gaerlan-Resureccion, E., Gaga, M., Galvez Romero, J. L., Gamkrelidze, A., Garcia, A., Garcia Cobas, C. Y., Garcia Cruz, M. D. L. L. H., Gayraud, J., Gemicioglu, B., Genova, S., Gereda, J., Gerth Van Wijk, R., Gomez, M., Gonzalez Diaz, S., Gotua, M., Grigoreas, C., Grisle, I., Guidacci, M., Guldemond, N., Gutter, Z., Guzman, A., Halloum, R., Hamelmann, E., Hammadi, S., Harvey, R., Heinrich, J., Hejjaoui, A., Hellquist-Dahl, B., Hernandez Velazquez, L., Hew, M., Hossny, E., Howarth, P., Hrubisko, M., Huerta Villalobos, Y. R., Humbert, M., Hyland, M., Ibrahim, M., Ilyina, N., Irani, C., Ispayeva, Z., Jares, E., Jarvis, D., Jassem, E., Jenko, K., Jimeneracruz Uscanga, R. D., Johnston, S., Joos, G., Jost, M., Julge, K., Jung, K. -S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, F., Kapsali, J., Kardas, P., Karjalainen, J., Kasala, C. A., Katotomichelakis, M., Kazi, B., Keil, T., Keith, P., Khaitov, M., Khaltaev, N., Kim, Y. -Y., Kleine-Tebbe, J., Koffi N'Goran, B., Kompoti, E., Kopac, P., Koppelman, G., Koren Jeverica, A., Kosnik, M., Kostov, K. V., Kowalski, M. L., Kralimarkova, T., Kramer Vrscaj, K., Kraxner, H., Kreft, S., Kritikos, V., Kudlay, D., Kull, I., Kupczyk, M., Kvedariene, V., Kyriakakou, M., Lalek, N., Lane, S., Latiff, A., Lau, S., Lavrut, J., Le, L., Lessa, M., Levin, M., Li, J., Lieberman, P., Liotta, G., Lipworth, B., Liu, X., Lobo, R., Lodrup Carlsen, K. C., Lombardi, C., Louis, R., Loukidis, S., Lourenco, O., Luna Pech, J. A., Madjar, B., Magnan, A., Mahboub, B., Mair, A., Mais, Y., Maitland Van Der Zee, A. -H., Makela, M., Makris, M., Malling, H. -J., Mandajieva, M., Manning, P., Manousakis, M., Maragoudakis, P., Marshall, G., Martinsmartins, P., Masjedi, M. R., Maspero, J. F., Matta Campos, J. J., Maurer, M., Mavale-Manuel, S., Meco, C., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Menzies-Gow, A., Merk, H., Michel, J. -P., Miculinic, N., Midao, L., Mihaltan, F., Mikael, K., Mikos, N., Milenkovic, B., Mitsias, D., Moalla, B., Moda, G., Mogica Martinez, M. D., Mohammad, Y., Moin, M., Molimard, M., Momas, I., Monaco, A., Montefort, S., Mora, D., Morais-Almeida, M., Mosges, R., Mostafa, B. E., Munter, L., Muraro, A., Murray, R., Mustakov, T., Naclerio, R., Nadif, R., Nakonechna, A., Namazova-Baranova, L., Navarro-Locsin, G., Neffen, H., Nekam, K., Neou, A., Nicod, L., Niederberger-Leppin, V., Niedoszytko, M., Nieto, A., Novellino, E., Nunes, E., Nyembue, D., O'Hehir, R., Odjakova, C., Ohta, K., Okamoto, Y., Okubo, K., Oliver, B., Onorato, G. L., Orru, M. P., Ouedraogo, S., Ouoba, K., Paggiaro, P. L., Pagkalos, A., Palaniappan, S. P., Pali-Scholl, I., Palkonen, S., Palmer, S., Panaitescu Bunu, C., Panzner, P., Papanikolaou, V., Papi, A., Paralchev, B., Paraskevopoulos, G., Park, H. S., Passalacqua, G., Patella, V., Pavord, I., Pawankar, R., Pedersen, S., Peleve, S., Pereira, A., Perez, T., Pham-Thi, N., Pigearias, B., Pin, I., Piskou, K., Pitsios, C., Pitsios, K., Plavec, D., Poethig, D., Pohl, W., Poplas Susic, A., Popov, T. A., Portejoie, F., Potter, P., Poulsen, L., Prados-Torres, A., Prarros, F., Price, D., Prokopakis, E., Puy, R., Rabe, K., Raciborski, F., Ramos, J., Recto, M. T., Reda, S. M., Regateiro, F., Reider, N., Reitsma, S., Repka-Ramirez, S., Rimmer, J., Rivero Yeverino, D., Rizzo, J. A., Robalo-Cordeiro, C., Roberts, G., Roche, N., Rodriguez Gonzalez, M., Rodriguez Zagal, E., Rolland, C., Roller-Wirnsberger, R., Roman Rodriguez, M., Romano, A., Rombaux, P., Romualdez, J., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Rouadi, P., Rovina, N., Rozman Sinur, I., Ruiz, M., Ruiz Segura, L. T., Ryan, D., Sagara, H., Sakai, D., Sakurai, D., Saleh, W., Salimaki, J., Salina, H., Samitas, K., Sanchez Coronel, M. G., Sanchez-Borges, M., Sanchez-Lopez, J., Sarafoleanu, C., Sarquis Serpa, F., Sastre-Dominguez, J., Scadding, G., Scheire, S., Schmid-Grendelmeier, P., Schuhl, J. F., Schunemann, H., Schvalbova, M., Scichilone, N., Sepulveda, C., Serrano, E., Sheikh, A., Shields, M., Shishkov, V., Siafakas, N., Simeonov, A., Simons, E. F., Sisul, J. C., Sitkauskiene, B., Skrindo, I., Soklic Kosak, T., Sole, D., Sooronbaev, T., Soto-Martinez, M., Sova, M., Spertini, F., Spranger, O., Stamataki, S., Stefanaki, L., Stellato, C., Stelmach, R., Sterk, P., Strandberg, T., Stute, P., Subramaniam, A., Suppli Ulrik, C., Sutherland, M., Sylvestre, S., Syrigou, A., Taborda Barata, L., Takovska, N., Tan, R., Tan, F., Tan, V., Tang, I. P., Taniguchi, M., Tannert, L., Tattersall, J., Teixeira, M. D. C., Thijs, C., Thomas, M., To, T., Todo-Bom, A. M., Togias, A., Tomazic, P. -V., Toppila-Salmi, S., Toskala, E., Triggiani, M., Triller, N., Triller, K., Tsiligianni, I., Ulmeanu, R., Urbancic, J., Urrutia Pereira, M., Vachova, M., Valdes, F., Valenta, R., Valentin Rostan, M., Valero, A., Vallianatou, M., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vassileva, D., Ventura, M. T., Vera-Munoz, C., Vicheva, D., Vichyanond, P., Vidgren, P., Viegi, G., Vogelmeier, C., Von Hertzen, L., Vontetsianos, T., Vourdas, D., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Wickman, M., Williams, S., Williams, D., Wilson, N., Woo, K., Wright, J., Wroczynski, P., Xepapadaki, P., Yakovliev, P., Yamaguchi, M., Yan, K., Yap, Y. Y., Yawn, B., Yiallouros, P., Yoshihara, S., Young, I., Yusuf, O. B., Zaidi, A., Zaitoun, F., Zar, H., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M., Zubrinich, C., University of Zurich, Bousquet, Jean, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), 'Federico II' University of Naples Medical School, Medical Consulting Czarlewski, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Euromov (EuroMov), Université de Montpellier (UM), IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy., Vall d'Hebron University Hospital [Barcelona], ProAR – Nucleo de Excelencia em Asma, Universidade Federal da Bahia (UFBA), Global Alliance Against Chronic Respiratory Diseases (GARD-WHO), Division for Health Innovation, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Wrocław Medical University, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Barlicki University Hospital, KYomed INNOV [Montpellier], Hospital Medica Sur [Mexico City, Mexico], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Royal Manchester Children's Hospital, University of Manchester [Manchester], General Children's Hospital of Athens P & A Kyriakou, Philipps Universität Marburg = Philipps University of Marburg, Medical University of Warsaw - Poland, Vilnius University [Vilnius], Manisa Celal Bayar University, and Salvy-Córdoba, Nathalie
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BLOOD-PRESSURE ,Review ,Angiotensin-converting enzyme ,Antioxidant ,Coronavirus ,Diet ,Food ,law.invention ,Dietary interventions ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,10183 Swiss Institute of Allergy and Asthma Research ,law ,Medicine and Health Sciences ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,education.field_of_study ,Mortality rate ,3. Good health ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,2723 Immunology and Allergy ,Angiotensin-converting enzyme, Antioxidant, Coronavirus, Diet, Food ,Pulmonary and Respiratory Medicine ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Coronaviru ,Immunology ,Population ,610 Medicine & health ,COVID-19 ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,03 medical and health sciences ,Environmental health ,population ,angiotensin-converting enzyme ,Quarantine ,education ,2403 Immunology ,ANTIHYPERTENSIVE PEPTIDES ,business.industry ,RC581-607 ,GENE ,POLYMORPHISM ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,030228 respiratory system ,2740 Pulmonary and Respiratory Medicine ,Immunologic diseases. Allergy ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Regional differences ,Coronavirus Infections - Abstract
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
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- 2020
26. Relationship between Peak Inspiratory Flow and Patient and Disease Characteristics in Individuals with COPD-A Systematic Scoping Review
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Leving, Marika T., Kocks, J.W., Bosnic-Anticevich, S., Dekhuijzen, R., Usmani, O.S., Leving, Marika T., Kocks, J.W., Bosnic-Anticevich, S., Dekhuijzen, R., and Usmani, O.S.
- Abstract
Contains fulltext : 247754.pdf (Publisher’s version ) (Open Access)
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- 2022
27. Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app.
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Sousa-Pinto, B, Anto, J M, Amaral, R, Brussino, L, Canonica, G W, Cruz, A A, Gemicioglu, B, Haahtela, T, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Louis, R, Pham-Thi, N, Puggioni, F, Regateiro, F S, Romantowski, J, Sastre, J, Scichilone, N, Taborda-Barata, L, Ventura, M T, Agache, I, Bedbrook, A, Bergmann, K C, Bosnic-Anticevich, S, Bonini, M, Boulet, L-P, Brusselle, G, Buhl, R, Cecchi, L, Charpin, D, Chaves-Loureiro, C, Czarlewski, W, de Blay, F, Devillier, P, Joos, G, Jutel, M, Klimek, L, Kuna, P, Laune, D, Pech, J L, Makela, M, Morais-Almeida, M, Nadif, R, Niedoszytko, M, Ohta, K, Papadopoulos, N G, Papi, A, Yeverino, D R, Roche, N, Sá-Sousa, A, Samolinski, B, Shamji, M H, Sheikh, A, Suppli Ulrik, C, Usmani, O S, Valiulis, A, Vandenplas, Olivier, Yorgancioglu, A, Zuberbier, T, Fonseca, J A, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Sousa-Pinto, B, Anto, J M, Amaral, R, Brussino, L, Canonica, G W, Cruz, A A, Gemicioglu, B, Haahtela, T, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, D E, Louis, R, Pham-Thi, N, Puggioni, F, Regateiro, F S, Romantowski, J, Sastre, J, Scichilone, N, Taborda-Barata, L, Ventura, M T, Agache, I, Bedbrook, A, Bergmann, K C, Bosnic-Anticevich, S, Bonini, M, Boulet, L-P, Brusselle, G, Buhl, R, Cecchi, L, Charpin, D, Chaves-Loureiro, C, Czarlewski, W, de Blay, F, Devillier, P, Joos, G, Jutel, M, Klimek, L, Kuna, P, Laune, D, Pech, J L, Makela, M, Morais-Almeida, M, Nadif, R, Niedoszytko, M, Ohta, K, Papadopoulos, N G, Papi, A, Yeverino, D R, Roche, N, Sá-Sousa, A, Samolinski, B, Shamji, M H, Sheikh, A, Suppli Ulrik, C, Usmani, O S, Valiulis, A, Vandenplas, Olivier, Yorgancioglu, A, Zuberbier, T, and Fonseca, J A
- Abstract
The self-reporting of asthma frequently leads to patient misidentification in epidemiological studies. Strategies combining the triangulation of data sources may help to improve the identification of people with asthma. We aimed to combine information from the self-reporting of asthma, medication use and symptoms to identify asthma patterns in the users of an mHealth app. We studied MASK-air® users who reported their daily asthma symptoms (assessed by a 0-100 visual analogue scale - "VAS Asthma") at least three times (either in three different months or in any period). K-means cluster analysis methods were applied to identify asthma patterns based on: (i) whether the user self-reported asthma; (ii) whether the user reported asthma medication use and (iii) VAS asthma. Clusters were compared by the number of medications used, VAS asthma levels and Control of Asthma and Allergic Rhinitis Test (CARAT) levels. We assessed a total of 8,075 MASK-air® users. The main clustering approach resulted in the identification of seven groups. These groups were interpreted as probable: (i) severe/uncontrolled asthma despite treatment (11.9-16.1% of MASK-air® users); (ii) treated and partly-controlled asthma (6.3-9.7%); (iii) treated and controlled asthma (4.6-5.5%); (iv) untreated uncontrolled asthma (18.2-20.5%); (v) untreated partly-controlled asthma (10.1-10.7%); (vi) untreated controlled asthma (6.7-8.5%) and (vii) no evidence of asthma (33.0-40.2%). This classification was validated in a study of 192 patients enrolled by physicians. We identified seven profiles based on the probability of having asthma and on its level of control. mHealth tools are hypothesis-generating and complement classical epidemiological approaches in identifying patients with asthma.
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- 2022
28. Characterisation of the Australian Adult Population Living with Asthma: Severe - Exacerbation Frequency, Long-Term OCS Use and Adverse Effects.
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Hancock, KL, Bosnic-Anticevich, S, Blakey, JD, Hew, M, Chung, LP, Cvetkovski, B, Claxton, S, Del Fante, P, Denton, E, Doan, J, Ranasinghe, K, Morgan, L, Sharma, A, Smith, PK, Stewart, D, Thompson, PJ, Wiseman, R, Upham, JW, Yan, KY, Carter, V, Dhillon, K, Heraud, F, Le, T, Vella, R, Price, D, OPCA Improving Asthma outcomes in Australia Research Group, Hancock, KL, Bosnic-Anticevich, S, Blakey, JD, Hew, M, Chung, LP, Cvetkovski, B, Claxton, S, Del Fante, P, Denton, E, Doan, J, Ranasinghe, K, Morgan, L, Sharma, A, Smith, PK, Stewart, D, Thompson, PJ, Wiseman, R, Upham, JW, Yan, KY, Carter, V, Dhillon, K, Heraud, F, Le, T, Vella, R, Price, D, and OPCA Improving Asthma outcomes in Australia Research Group
- Abstract
INTRODUCTION: Asthma poses a significant burden for the Australian population. Understanding severe exacerbation rates, and steroid-related burden for adults diagnosed with asthma stands to offer insights into how this could be reduced. METHODS: Electronic medical records (EMR) and questionnaires from the Optimum Patient Care Research Database Australia (OPCRDA) were utilised retrospectively. OPCRDA is a real-world database with >800,000 medical records from Australian primary care practices. Outcomes were severe asthma exacerbations in Australian adults, over a 12-month period, stratified by Global Initiative for Asthma (GINA) treatment intensity steps, and steroid associated comorbidities. RESULTS: Of the 7868 adults treated for asthma, 19% experienced at least one severe exacerbation in the last 12-months. Severe exacerbation frequency increased with treatment intensity (≥1 severe exacerbation GINA 1 13%; GINA 4 23%; GINA 5a 33% and GINA 5b 28%). Questionnaire participants reported higher rates of severe exacerbations than suggested from their EMR (32% vs 23%) especially in steps 1, 4 and 5. Patients repeatedly exposed to steroids had an increased risk of osteoporosis (OR 1.95, 95% CI 1.43-2.66) and sleep apnoea (OR 1.78, 95% CI 1.30-2.46). CONCLUSION: The Australian population living with GINA 1, 4, 5a and 5b asthma have high severe exacerbation rates and steroid-related burden, especially when compared to other first world countries, with these patients needing alternative strategies or possibly specialist assessment to better manage their condition.
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- 2022
29. Work productivity in rhinitis using cell phones: The MASK pilot study
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Bousquet, J., Bewick, M., Arnavielhe, S., Mathieu‐Dupas, E., Murray, R., Bedbrook, A., Caimmi, D. P., Vandenplas, O., Hellings, P. W., Bachert, C., Anto, J. M., Bergmann, K. C., Bindslev‐Jensen, C., Bosnic‐Anticevich, S., Bouchard, J., Canonica, G. W., Chavannes, N. H., Cruz, A. A., Dahl, R., Demoly, P., De Vries, G., Devillier, P., Fink‐Wagner, A., Fokkens, W. J., Fonseca, J., Guldemond, N. A., Haahtela, T., Hellqvist‐Dahl, B., Just, J., Keil, T., Klimek, L., Kowalski, M. L., Kuna, P., Kvedariene, V., Laune, D., Larenas‐Linnemann, D., Mullol, J., Pereira, A. M., Carreiro‐Martins, P., Melén, E., Morais‐Almeida, M., Nogueira‐Silva, L., OʼHehir, R. E., Papadopoulos, N. G., Passalacqua, G., Portejoie, F., Price, D., Ryan, D., Samolinski, B., Sheikh, A., Simons, F. E. R., Spranger, O., Todo Bom, A., Tomazic, P. V., Triggiani, M., Valero, A., Valovirta, E., Valiulis, A., van Eerd, M., Wickman, M., Young, I., and Zuberbier, T.
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- 2017
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30. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement
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Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal‐Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W, Agache, I, Akdis, CA, Akdis, M, Alobid, I, Ankri, J, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Asarnoj, A, Avolio, F, Bachert, C, Bachert, C, Baiardini, I, Barbagallo, M, Barbara, C, Baroody, F, Bateman, ED, Bedbrook, A, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bergmann, KC, Bewick, M, Bialoszewski, AZ, Bieber, T, Bindslev‐Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic‐Anticevich, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, J, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero‐Fonseca, F, Caimmi, DP, Calderon, MA, Camargos, PA, Camuzat, T, Canonica, GW, Cardona, V, Carlsen, KH, Carr, W, Carreiro‐Martins, P, Carriazo, AM, Casale, T, Cepeda Sarabia, AM, Cervin, A, Cesari, M, Chatzi, L, Chavannes, NH, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cohen, N, Conzález Diaz, S, Cox, L, Crooks, G, Cruz, AA, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Manuel Keenoy, E, de Sousa, JC, De Vries, G, Dedeu, T, Deleanu, D, Demoly, P, Denburg, JA, Devillier, P, Didier, A, Dinh‐Xuan, AT, Dokic, D, Douagui, H, Douglas, R, Dray, G, Du Toit, G, Dubakiene, R, Durham, SR, Dykewicz, MS, Eklund, P, El‐Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Fokkens, WJ, Fonseca, J, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Georgalas, C, Gereda, JE, Gevaert, P, Goossens, H, Grisle, I, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T, Harvey, R, Heinrich, J, Hellings, PW, Hellings, PW, Hellquist‐Dahl, B, Hopkins, C, Horak, F, Hourihane, JO, Humbert, M, Hyland, M, Iaccarino, G, Illario, M, Jares, EJ, Jeandel, C, Johnston, SL, Jonquet, O, Joos, G, Joos, G, Jung, KS, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalogjera, L, Kalyoncu, AF, Kardas, P, Keil, T, Keith, PK, Kerkhof, M, Kern, B, Kerstjens, HA, Khaitov, M, Khaltaev, N, Klimek, L, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, M, Kowalski, ML, Kuitunen, M, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Larenas‐Linnemann, D, Lau, S, Laune, D, Le, LT, Li, J, Lieberman, P, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lund, VJ, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, Marshall, GD, Masjedi, MR, Mathieu‐Dupas, E, Maurer, M, Mavale‐Manuel, S, Melén, E, Melo‐Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot‐Keurinck, J, Mohammad, Y, Momas, I, Morais‐Almeida, M, Mösges, R, Mullol, J, Mullol, J, Muraro, A, Murray, R, Naclerio, R, Nadif, R, Namazova‐Baranova, L, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira‐Silva, L, Nogues, M, Nyembue, TD, OʼHehir, RE, Ohta, K, Okamoto, Y, Okubo, K, Olive‐Elias, M, Ouedraogo, S, Paggiaro, P, Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Papi, A, Park, HS, Passalacqua, G, Pawankar, R, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Potter, P, Poulsen, LK, Price, D, Price, D, Rabe, KF, Raciborski, F, Riechelmann, H, Robalo‐Cordeiro, C, Roberts, G, Rodenas, F, Rodriguez‐Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado‐Pinto, J, Rosario, N, Rottem, M, Ryan, D, Samolinski, B, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schlosser, R, Schmid‐Grendelmeier, P, Schunemann, HJ, Scichilone, N, Senior, B, Serrano, E, Sheikh, A, Shields, M, Simons, FER, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stellato, C, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Thomas, M, Todo‐Bom, A, Tomazic, PV, Toskala, E, Triggiani, M, Valenta, R, Valero, A, Valiulis, A, Valovirta, E, van Eerd, M, van Ganse, E, van Hage, M, van Wick, RG, Vandenplas, O, Varona, LL, Vazankari, T, Vellas, B, Ventura, MT, Vezzani, G, Viegi, G, Voegels, R, Vontetsianos, T, Wagenmann, M, Wahn, U, Walker, S, Wang, DY, Wang, Y, Werfel, T, Whalley, B, Wickman, M, Williams, DM, Williams, S, Wilson, N, Wormald, PJ, Wright, J, Yawn, BP, Yiallouros, PK, Yorgancioglu, A, Young, I, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, Zidarn, M, and Zuberbier, T
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- 2017
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31. P55: TELL ME ABOUT YOUR HAY FEVER: A QUALITATIVE INVESTIGATION OF THE PATIENT PERSPECTIVES OF ALLERGIC RHINITIS
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Cvetkovski, B, Yan, K, Kritikos, V, and Bosnic‐Anticevich, S
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- 2017
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32. Exploring Use of Regular ICS/LABA Dosing in Moderate to Severe Asthma Among Physicians: Results from the Asthma Patients’ and Physicians’ peRspectives on the burden and managemENT of asthma studies (APPaRENT 1 & 2)
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Chapman, K.R., primary, Bosnic-Anticevich, S., additional, Cano, M.D.C., additional, and PG, A., additional
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- 2022
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33. Development and validation of combined symptom-medication scores for allergic rhinitis*
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Sousa-Pinto, B. Azevedo, L.F. Jutel, M. Agache, I. Canonica, G.W. Czarlewski, W. Papadopoulos, N.G. Bergmann, K.-C. Devillier, P. Laune, D. Klimek, L. Anto, A. Anto, J.M. Eklund, P. Almeida, R. Bedbrook, A. Bosnic-Anticevich, S. Brough, H.A. Brussino, L. Cardona, V. Casale, T. Cecchi, L. Charpin, D. Chivato, T. Costa, E.M. Cruz, A.A. Dramburg, S. Durham, S.R. De Feo, G. Gerth van Wijk, R. Fokkens, W.J. Gemicioglu, B. Haahtela, T. Illario, M. Ivancevich, J.C. Kvedariene, V. Kuna, P. Larenas-Linnemann, D.E. Makris, M. Mathieu-Dupas, E. Melén, E. Morais-Almeida, M. Mösges, R. Mullol, J. Nadeau, K.C. Pham-Thi, N. O’Hehir, R. Regateiro, F.S. Reitsma, S. Samolinski, B. Sheikh, A. Stellato, C. Todo-Bom, A. Tomazic, P.V. Toppila-Salmi, S. Valero, A. Valiulis, A. Ventura, M.T. Wallace, D. Waserman, S. Yorgancioglu, A. De Vries, G. van Eerd, M. Zieglmayer, P. Zuberbier, T. Pfaar, O. Almeida Fonseca, J. Bousquet, J.
- Abstract
Background: Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate hypothesis- and data-driven CSMSs. Methods: We used MASK-air® data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air® data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air®, and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results: We assessed 317,176 days of MASK-air® use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion: The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials. © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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- 2022
34. Assessment of the Control of Allergic Rhinitis and Asthma Test (CARAT) using MASK-air
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Agache, I., Basagaña, X., Bédard, A., Bergmann, K.C., Bindslev-Jensen, C., Blain, H., Bosnic-Anticevich, S., Bosse, I., Boulet, L.P., Brussino, L., Camargos, P., Canonica, G.W., Carreiro-Martins, P., Cardona, V., Cecchi, L., Chu, D., Costa, E., Cruz, A.A., da Silva, J., De Vries, G., Devillier, P., Fokkens, W.J., Fontaine, J.F., Fuentes-Pérez, J.-M., Gemicioğlu, B., Haahtela, T., Huerta-Villalobos, Y.R., Ivancevich, J.C., Jutel, M., Kaidashev, I., Khaitov, M., Klimek, L., Kraxner, H., Kuna, P., Kvedariene, V., Larenas-Linnemann, D.E.S., Laune, D., Lipworth, B., Manning, P., Makris, M., Melén, E., Morais-Almeida, M., Mösges, R., Mullol, J., Nekam, K., Niedoszytko, M., O'Hehir, R.E., Okamoto, Y., Papadopoulos, N.G., Patella, V., Pfaar, O., Pham-Thi, N., Regateiro, F.S., Reitsma, S., Rouadi, P.W., Samolinski, B., Sarquis-Serpa, F., Sastre, J., Scichilone, N., Stelmach, R., Suppli-Ulrik, C., Todo-Bom, A., Tomazic, P.V., Toppila-Salmi, S., Tsigiliani, I., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., Ventura, M.T., Waserman, S., Yorgancioglu, A., Zidarn, M., Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Amaral, Rita, Czarlewski, Wienczyslawa, Bedbrook, Anna, Anto, Josep M., Bousquet, Jean, and Fonseca, João Almeida
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- 2022
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35. Management of allergic rhinitis in the community pharmacy: identifying the reasons behind medication self-selection
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Tan R, Cvetkovski B, Kritikos V, Yan K, Price D, Smith P, and Bosnic-Anticevich S.
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Rhinitis Allergic ,Seasonal ,Self Medication ,Quality of Life ,Community Pharmacy Services ,Professional Role ,Pharmacies ,Surveys and Questionnaires ,Multivariate Analysis ,Australia ,Therapeutics. Pharmacology ,RM1-950 ,Pharmacy and materia medica ,RS1-441 - Abstract
Background: Community pharmacists have a key role to play in the management of allergic rhinitis (AR). Their role is especially important because the majority of medications used to treat AR are available for purchase over-the-counter (OTC), allowing patients to self-select their own medications and bypass the pharmacists. Patients’ self-selection often results in suboptimal treatment selection, undertreated AR and poor clinical outcomes. In order for pharmacists to optimise the care for AR patients in the pharmacy, pharmacists need to be able to identify patient cohorts who self-select and are at high risk of mismanagement. Objectives: This study aimed to compare the demographics, clinical characteristics and medication selected, between pharmacy customers who choose to self-select and those who speak with a pharmacist when purchasing medication for their AR in a community pharmacy and identify factors associated with AR patients’ medication(s) self-selection behaviour. Methods: A cross-sectional observational study was conducted in a convenience sample of community pharmacies from the Sydney metropolitan area. Demographics, pattern of AR symptoms, their impact on quality of life (QOL) and medication(s) selected, were collected. Logistic regressions were used to identify factors associated with participants’ medication self-selection behaviour. Results: Of the 296 recruited participants, 202 were identified with AR; 67.8% were female, 54.5% were >40 years of age, 64.9% had a doctor’s diagnosis of AR, and 69.3% self-selected medication(s). Participants with AR who self-select were 4 times more likely to experience moderate-severe wheeze (OR 4.047, 95% CI 1.155-14.188) and almost 0.4 times less likely to experience an impact of AR symptoms on their QOL (OR 0.369, 95% CI 0.188-0.727). Conclusions: The factors associated with AR patients’ self-selecting medication(s) are the presence of wheeze and the absence of impact on their QOL due to AR symptoms. By identifying this cohort of patients, our study highlights an opportunity for pharmacists to engage these patients and encourage discussion about their AR and asthma management.
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- 2018
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36. Assessment of the Control of Allergic Rhinitis and Asthma Test (CARAT) using MASK-air
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Sousa-Pinto, Bernardo, primary, Sá-Sousa, Ana, additional, Amaral, Rita, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Anto, Josep M., additional, Bousquet, Jean, additional, Fonseca, João Almeida, additional, Agache, I., additional, Basagaña, X., additional, Bédard, A., additional, Bergmann, K.C., additional, Bindslev-Jensen, C., additional, Blain, H., additional, Bosnic-Anticevich, S., additional, Bosse, I., additional, Boulet, L.P., additional, Brussino, L., additional, Camargos, P., additional, Canonica, G.W., additional, Carreiro-Martins, P., additional, Cardona, V., additional, Cecchi, L., additional, Chu, D., additional, Costa, E., additional, Cruz, A.A., additional, da Silva, J., additional, De Vries, G., additional, Devillier, P., additional, Fokkens, W.J., additional, Fontaine, J.F., additional, Fuentes-Pérez, J.-M., additional, Gemicioğlu, B., additional, Haahtela, T., additional, Huerta-Villalobos, Y.R., additional, Ivancevich, J.C., additional, Jutel, M., additional, Kaidashev, I., additional, Khaitov, M., additional, Klimek, L., additional, Kraxner, H., additional, Kuna, P., additional, Kvedariene, V., additional, Larenas-Linnemann, D.E.S., additional, Laune, D., additional, Lipworth, B., additional, Manning, P., additional, Makris, M., additional, Melén, E., additional, Morais-Almeida, M., additional, Mösges, R., additional, Mullol, J., additional, Nekam, K., additional, Niedoszytko, M., additional, O'Hehir, R.E., additional, Okamoto, Y., additional, Papadopoulos, N.G., additional, Patella, V., additional, Pfaar, O., additional, Pham-Thi, N., additional, Regateiro, F.S., additional, Reitsma, S., additional, Rouadi, P.W., additional, Samolinski, B., additional, Sarquis-Serpa, F., additional, Sastre, J., additional, Scichilone, N., additional, Stelmach, R., additional, Suppli-Ulrik, C., additional, Todo-Bom, A., additional, Tomazic, P.V., additional, Toppila-Salmi, S., additional, Tsigiliani, I., additional, Valero, A., additional, Valiulis, A., additional, Valovirta, E., additional, van Eerd, M., additional, Ventura, M.T., additional, Waserman, S., additional, Yorgancioglu, A., additional, and Zidarn, M., additional
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- 2022
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37. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
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Bousquet, J., Bedbrook, A., Czarlewski, W., Onorato, G. L., Arnavielhe, S., Laune, D., Mathieu-Dupas, E., Fonseca, J., Costa, E., Lourenço, O., Morais-Almeida, M., Todo-Bom, A., Illario, M., Menditto, E., Canonica, G. W., Cecchi, L., Monti, R., Napoli, L., Ventura, M. T., De Feo, G., Fokkens, W. J., Chavannes, N. H., Reitsma, S., Cruz, A. A., Da Silva, J., Serpa, F. S., Larenas-Linnemann, D., Fuentes Perez, J. M., Huerta-Villalobos, Y. R., Rivero-Yeverino, D., Rodriguez-Zagal, E., Valiulis, A., Dubakiene, R., Emuzyte, R., Kvedariene, V., Annesi-Maesano, I., Blain, H., Bonniaud, P., Bosse, I., Dauvilliers, Y., Devillier, P., Fontaine, J. F., Pépin, J. L., Pham-Thi, N., Portejoie, F., Picard, R., Roche, N., Rolland, C., Schmidt-Grendelmeier, P., Kuna, P., Samolinski, B., Anto, J. M., Cardona, V., Mullol, J., Pinnock, H., Ryan, D., Sheikh, A., Walker, S., Williams, S., Becker, S., Klimek, L., Pfaar, O., Bergmann, K. C., Mösges, R., Zuberbier, T., Roller-Wirnsberger, R. E., Tomazic, P. V., Haahtela, T., Salimäki, J., Toppila-Salmi, S., Valovirta, E., Vasankari, T., Gemicioǧlu, B., Yorgancioglu, A., Papadopoulos, N. G., Prokopakis, E. P., Tsiligianni, I. G., Bosnic-Anticevich, S., O'Hehir, R., Ivancevich, J. C., Neffen, H., Zernotti, M. E., Kull, I., Melén, E., Wickman, M., Bachert, C., Hellings, P. W., Brusselle, G., Palkonen, S., Bindslev-Jensen, C., Eller, E., Waserman, S., Boulet, L. P., Bouchard, J., Chu, D. K., Schünemann, H. J., Sova, M., De Vries, G., Van Eerd, M., Agache, I., Ansotegui, I. J., Bewick, M., Casale, T., Dykewick, M., Ebisawa, M., Murray, R., Naclerio, R., Okamoto, Y., Wallace, D. V., Aberer, W., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bjermer, L., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Castellano, G., Cepeda, A. M., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortés-Grimaldo, R. M., Corti, F., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Custovic, A., Dahlen, S. 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J., Zhang, L., Zhong, N., Zhanat, I., Zidarn, M., Zubrinich, C., Zurkuhlen, A., Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), KYomed INNOV, University of Coimbra [Portugal] (UC), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - 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S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M. L., Kuitunen, M., Kupczyk, M., Krzych-Falta, E., Lacwik, P., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Mora Bogado, D., Morato-Castro, F. F., Mota-Pinto, A., Moura Santo, P., Munter, L., Muraro, A., Nadif, R., Nalin, M., Namazova-Baranova, L., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okubo, K., Ortega Cisneros, M., Ouedraogo, S., Pali-Scholl, I., Panzner, P., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pereira, A. M., Persico, M., Phillips, J., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Potter, P., Pozzi, A. C., Price, D., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Ribeirinho, I., Rimmer, J., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Manas, L., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rolla, G., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Sagara, H., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Scichilone, N., Schmid-Grendelmeier, P., Shamai, S., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, J. N., Thibaudon, M., To, T., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Van Ganse, E., Van Hague, M., Vandenplas, O., Vezzani, G., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Wallace, D., Wang, D. Y., Werfel, T., Westman, M., Williams, D. M., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zhanat, I., Zidarn, M., Zubrinich, C., Zurkuhlen, A., UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie
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SENTINEL NETWORK ,Allergy ,Respiratory Medicine and Allergy ,Review ,WORLD-HEALTH-ORGANIZATION ,Disease ,Rhinitis ,App ,Asthma ,Care pathways ,DG Santé ,MASK ,mHealth ,0302 clinical medicine ,QUALITY-OF-LIFE ,PRECISION MEDICINE ,Health care ,Medicine and Health Sciences ,GRADING QUALITY ,Immunology and Allergy ,Medicine ,Rinitis ,Lungmedicin och allergi ,0303 health sciences ,The MASK study group ,Public sector ,DG Sante ,MOBILE TECHNOLOGY ,3. Good health ,ALLERGIC RHINITIS ,CHRONIC RESPIRATORY-DISEASES ,Rinite ,EUROPEAN SYMPOSIUM ,CLINICAL-PRACTICE GUIDELINES ,Life Sciences & Biomedicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Immunology ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Predictive medicine ,03 medical and health sciences ,Quality of life (healthcare) ,App -MASK ,Asma ,030304 developmental biology ,ARIA ,Science & Technology ,Care pathway ,business.industry ,Change management ,Correction ,RC581-607 ,medicine.disease ,030228 respiratory system ,Family medicine ,Immunologic diseases. Allergy ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
AIMS: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. METHODS: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. STAKEHOLDERS: Include patients, health care professionals (pharmacists and physicians), authorities, patient's associations, private and public sectors. RESULTS: MASK is deployed in 23 countries and 17 languages. 26,000 users have registered. EU GRANTS 2018: MASK is participating in EU projects (POLLAR: impact of air POLLution in Asthma and Rhinitis, EIT Health, DigitalHealthEurope, Euriphi and Vigour). LESSONS LEARNT: (i) Adherence to treatment is the major problem of allergic disease, (ii) Self-management strategies should be considerably expanded (behavioural), (iii) Change management is essential in allergic diseases, (iv) Education strategies should be reconsidered using a patient-centred approach and (v) Lessons learnt for allergic diseases can be expanded to chronic diseases. ispartof: CLINICAL AND TRANSLATIONAL ALLERGY vol:9 issue:1 ispartof: location:England status: published
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- 2019
38. Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement
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Bousquet, J., Akdis, C. A., Jutel, M., Bachert, C., Klimek, L., Agache, I., Ansotegui, I. J., Bedbrook, A., Bosnic-Anticevich, S., Canonica, G. W., Chivato, T., Cruz, A. A., Czarlewski, W., Del Giacco, S., Du, H., Fonseca, J. A., Gao, Y., Haahtela, T., Hoffmann-Sommergruber, K., Ivancevich, J. -C., Khaltaev, N., Knol, E. F., Kuna, P., Larenas-Linnemann, D., Mullol, J., Naclerio, R., Ohta, K., Okamoto, Y., O'Mahony, L., Onorato, G. L., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Schwarze, J., Toppila-Salmi, S., Ventura, M. -T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Pawankar, R., Mubeccel, A., Mona, A. -A., Emilio, A. C., Hasan, A., Cristina, A. M., Zeinab, A., Mostafa, B. E., Sergio, B., Cristina, B., Eric, B., Bianca, B., Elisabeth, B., Larl-Christian, B., David, B., Leif, B., Attilio, B., Isabelle, B., Jacques, B., Louis-Philippe, B., Fulvio, B., Christopher, B., Roland, B., Carmen, B., Andrew, B., William, B., Fernan, C. -F., Davide, C., Silvia, C., Paulo, C., Walter, C., Vicky, C., Kai-Hakon, C., Warner, C., Thomas, C., Lorenzo, C., Alfonso, C. M., Niels, C., Ekaterine, C., George, C., Derek, C., Cemal, C., Giorgio, C., Ieva, C., Sousa Jaime, C. D., Maria del Carmen, C. D., Andre, C., Linda, C., Alvaro, C., Adnan, C., Ulf, D., Frederic, D. B., Diana, D., Pascal, D., Philippe, D., Alain, D., Ratko, D., Maria, D. C. T., Dejan, D., Ruta, D., Stephen, D., Patrik, E., Yehia, E. -G., Regina, E., Bieren Julia, E. -V., Alessandro, F., Wytske, F., Mina, G., Luis, G. R. J., Bilun, G., Sonya, G., Jose, G., Maximiliano, G., Maia, G., Ineta, G., Marta, G., Antonieta, G. M., Adnan, H., Elham, H., Jonathan, H., Martin, H., Yunuen, H. V., Guido, I., Carla, I., Zhanat, I., Edgardo, J., Ewa, J., Erika, J. -J., Sebastian, J., Guy, J., Ki-Suck, J., Jocelyne, J., Igor, K., Omer, K., Fuat, K., Przemyslaw, K., Jussi, K., Jorg, K. -T., Gerard, K., Marek, K., Mikael, K., Violeta, K., Amir, L., Susanne, L., Lan, L., Marcus, L., Michael, L., Jing, L., Philip, L., Brian, L., Karin, L. C., Bassam, M., Mika, M., Hans-Jorgen, M., Gailen, M., Pedro, M., Mohammad, M., Juan-Jose, M., Cem, M., Erik, M., Eli, M., Hans, M., Jean-Pierre, M., Florin, M., Neven, M., Branislava, M., Yousser, M., Mathieu, M., Mario, M. -A., Ralph, M., Lars, M., Antonella, M., Tihomir, M., Alla, N., Leyla, N. -B., Kristof, N., Laurent, N., Robyn, O., Kimihiro, O., Brian, O., Luigi, P. P., Isabella, P. -S., Petr, P., Nilos, P., Sim, P. H., Ruby, P., Ana, P., Bernard, P., Constantinos, P., Davor, P., Wolfgang, P., Todor, P., Fabienne, P., Paul, P., Lars, P., Emmanuel, P., Claus, R., Stella, R. M., Janet, R., Jose Angelo, R., Graham, R., Nicolas, R., Antonino, R., Jose, R. -P., Nelson, R., Lanny, R., Philip, R., Dermot, R., Mario, S. -B., Joaquin, S. -D., Glenis, S., Elie, S., Nikolaos, S., Estelle, S., Juan-Carlos, S., Dirceu, S., Talant, S., Manuel, S. -M., Cristiana, S., Rafael, S., Timo, S., Charlotte, S. U., Carel, T., Peter-Valentin, T., Massimo, T., Ioana, T., Marilyn, U. P., Erkka, V., Eric, V. G., Marianne, V. H., Olivier, V., Petra, V., Martin, W., Dana, W., Yun, W. D., Susan, W., Magnus, W., Dennis, W., Barbara, Y., Arzu, Y., Osman, Y., Mario, Z., Mihaela, Z., Beghe', Bianca, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, Bousquet, J., Akdis, C., Jutel, M., Bachert, C., Klimek, L., Agache, I., Ansotegui, I. J., Bedbrook, A., Bosnic-Anticevich, S., Canonica, G. W., Chivato, T., Cruz, A. A., Czarlewski, W., Del Giacco, S., Du, H., Fonseca, J. A., Gao, Y., Haahtela, T., Hoffmann-Sommergruber, K., Ivancevich, J. C., Khaltaev, N., Knol, E. F., Kuna, P., Larenas-Linnemann, D., Mullol, J., Naclerio, R., Ohta, K., Okamoto, Y., O'Mahony, L., Onorato, G. L., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Schwarze, J., Toppila-Salmi, S., Teresa Ventura, M., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Universitätsmedizin Berlin, Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, CharitéHumboldt-Universität zu BerlinBerlin, Germany, University Hospital Montpellier, France, MACVIA-France, Montpellier, France, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland, Department of Clinical Immunology, Wrocław Medical University, ALL-MED Medical Research Institute, Wroclaw, Poland, Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium, Center for Rhinology and Allergology, Wiesbaden, Germany, Transylvania University BrasovBrasov, Romania, Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Erandio, Spain, Woolcock Institute of Medical Research, University of Sydney, Woolcock Emphysema Centre, Sydney Local Health District, NSW, Australia, Personalized Medicine Clinic Asthma & Allergy, Humanitas University, Humanitas Research Hospital, Rozzano, Milan, Italy, Department of Biomedical Sciences, Humanitas University, MI, Pieve Emanuele, Italy, School of Medicine, University CEU San PabloMadrid, Spain, 3ProAR - Nucleo de Excelencia em Asma, Federal University of Bahia, Brasil and WHO GARD Planning Group, Salvador, Brazil, Medical Consulting Czarlewski, Montpellier, France, Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital 'Duilio Casula', University of Cagliari, Cagliari, Italy, Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, University of Science and Technology, Wuhan, Hubei, China, Center for research in health technologies and information systems- CINTESIS, Universidade do PortoPorto, Portugal, Allergy Unit, Instituto CUF Porto e Hospital CUF PortoPorto, Portugal, Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do PortoPorto, Portugal, Faculdade de Medicina da Universidade do PortoPorto, Portugal, Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland, Department of Pathophysiology and Allergy Research, Medical University of ViennaVienna, Austria, Servicio de Alergia e Immunologia, Clinica Santa IsabelBuenos Aires, Argentina, Geneva, Switzerland, Departments of Immunology and Dermatology/Allergology, University Medical Center UtrechtUtrecht, Netherlands, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and HospitalMéxico City, Mexico, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Spain, Johns Hopkins School of Medicine, Baltimore, MD, United States, National Hospital Organization, Tokyo National HospitalTokyo, Japan, Dept of Otorhinolaryngology, Chiba University HospitalChiba, Japan, Departments of Medicine and Microbiology, University College Cork, Cork, Ireland, Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of ManchesterManchester, United Kingdom, Allergy Dpt, Pediatric Clinic, University of Athens, Athens, Greece, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Germany, Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw, Poland, Centre for Inflammation Research, Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, University of Bari Medical School, Unit of Geriatric ImmunoallergologyBari, Italy, Vilnius University, Faculty of Medicine, Institute of Clinical Medicine &, Institute of Health SciencesVilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Celal Bayar University, Department of PulmonologyManisa, Turkey, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin Institute of Health, Comprehensive Allergy-Centre, Department of Dermatology and AllergyBerlin, Germany, AII - Inflammatory diseases, and Ear, Nose and Throat
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Statement (logic) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,education ,medicine.disease_cause ,Article ,corticosteroids ,03 medical and health sciences ,0302 clinical medicine ,Allergic ,Adrenal Cortex Hormones ,Administration, Intranasal ,Humans ,SARS-CoV-2 ,COVID-19 ,Rhinitis, Allergic ,medicine ,Immunology and Allergy ,biologics ,030223 otorhinolaryngology ,Coronavirus ,Rhinitis ,business.industry ,chronic rhinosinusitis ,allergy ,3. Good health ,030228 respiratory system ,Intranasal ,3121 General medicine, internal medicine and other clinical medicine ,Administration ,Nasal administration ,business - Published
- 2020
39. Aligning the good practice mask with the objectives of the European innovation partnership on active and healthy ageing
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Bousquet, J., Farrell, J., Illario, M., Onorato, G.L., Bedbrook, A., Czarlewski, W., Micheli, Y., Arnavielhe, S., Ansotegui, I.J., Anto, J.M., Bachert, C., Basagana, X., Bedard, A., Benveniste, S., Bergmann, K.C., Bewick, M., Bindslev-Jensen, C., Bjermer, L., Blain, H., Bosnic-Anticevich, S., Bosse, I., Braido, F., Brussino, L., Camuzat, T., Canonica, G.W., Cardona, V., Martins, P.C., Cecchi, L., Chavannes, N.H., Chu, D.K., Sousa, J.C. da, Costa, D.J., Costa, E., Cruz, A.A., Silva, J. da, Devillier, P., Feo, G. de, Vries, G. de, Dray, G., Ebisawa, M., Erhola, M., Fauquert, J.L., Fokkens, W.J., Fonseca, J., Fontaine, J.M., Gemicioglu, B., Haahtela, T., Heffler, E., Hellings, P.W., Ivancevich, J.C., Jassem, E., Jutel, M., Kaidashev, I., Kalayci, O., Klimek, L., Kowalski, M.L., Kull, I., Kuna, P., Kvedariene, V., Grutta, S. la, Laune, D., Larenas-Linnemann, D., Ierodiakonou, D., L.T.T. le, Lourenco, O., Makris, M., Menditto, E., Monti, R., Morais-Almeida, M., Munter, L., Muraro, A., Murray, R., Maurer, M., Melen, E., Mosges, R., Mullol, J., Niedoszytko, M., O'Hehir, R.E., Okamoto, Y., Papadopoulos, N.G., Passalacqua, G., Patella, V., Pereira, A.M., Pfaar, O., Pham-Thi, N., Portejoie, F., Price, D., Prokopakis, E.P., Psarros, F., Raciborski, F., Regateiro, F., Reitsma, S., Roche, N., Rolland, C., Ryan, D., Samolinski, B., Sastre, J., Scadding, G.K., Schmid-Grendelmeier, P., Schunemann, H.J., Shamji, M., Sheikh, A., Stellato, C., Suppli-Ulrik, C., Somekh, D., Sova, M., Bom, A.T., Tomazic, P.V., Toppila-Salmi, S., Triggiani, M., Tsiligianni, I., Valero, A., Valiulis, A., Valovirta, E., Eerd, M. van, Vasankari, T., Ventura, M.T., Wallace, D., Waserman, S., Yorgancioglu, A., Zidarn, M., Zuberbier, T., ARIA-MASK Study Grp, Bousquet, J., Farrell, J., Onorato, G. L., Bedbrook, A., Czarlewski, W., Micheli, Y., Arnavielhe, S., Illario, M., Ansotegui, I. J., Anto, J. M., Bachert, C., Basagana, X., Bedard, A., Benveniste, S., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bjermer, L., Blain, H., Bosnic-Anticevich, S., Bosse, I., Braido, F., Brussino, L., Camuzat, T., Canonica, G. W., Cardona, V., Carreiro Martins, P., Cecchi, L., Chavannes, N. H., Chu, D. K., Correia da Sousa, J., Costa, D. J., Costa, E., Cruz, A. A., da Silva, J., Devillier, P., de Feo, G., de Vries, G., Dray, G., Ebisawa, M., Erhola, M., Fauquert, J. L., Fokkens, W. J., Fonseca, J., Fontaine, J. M., Gemicioglu, B., Haahtela, T., Heffler, E., Hellings, P. W., Ivancevich, J. C., Jassem, E., Jutel, M., Kaidashev, I., Kalayci, O., Klimek, L., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., la Grutta, S., Laune, D., Larenas-Linnemann, D., Ierodiakonou, D., Le, L. T. T., Lourenco, O., Makris, M., Menditto, E., Monti, R., Morais-Almeida, M., Munter, L., Muraro, A., Murray, R., Maurer, M., Melen, E., Mosges, R., Mullol, J., Niedoszytko, M., O'Hehir, R. E., Okamoto, Y., Papadopoulos, N. G., Passalacqua, G., Patella, V., Pereira, A. M., Pfaar, O., Pham-Thi, N., Portejoie, F., Price, D., Prokopakis, E. P., Psarros, F., Raciborski, F., Regateiro, F., Reitsma, S., Roche, N., Rolland, C., Ryan, D., Samolinski, B., Sastre, J., Scadding, G. K., Schmid-Grendelmeier, P., Schunemann, H. J., Shamji, M., Sheikh, A., Stellato, C., Suppli-Ulrik, C., Somekh, D., Sova, M., Todo Bom, A., Tomazic, P. V., Toppila-Salmi, S., Triggiani, M., Tsiligianni, I., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., Vasankari, T., Ventura, M. T., Wallace, D., Waserman, S., Yorgancioglu, A., Zidarn, M., Zuberbier, T., Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ghent University Hospital, Department of Dermatology and Allergy Center, Odense University Hospital, The University of Sydney, Informatique, Image, Intelligence Artificielle (I3A), Laboratoire de Génie Informatique et d'Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-IMT - MINES ALES (IMT - MINES ALES), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
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Pulmonary and Respiratory Medicine ,Process management ,Allergy ,IMPACT ,Immunology ,Mobile application ,Review ,health ,Clinical decision support system ,GLOBAL ALLIANCE ,Asthma ,Health ,Healthy aging ,Mobile applications ,Rhinitis ,Financial management ,03 medical and health sciences ,[SPI]Engineering Sciences [physics] ,0302 clinical medicine ,Blueprint ,QUALITY-OF-LIFE ,HDE ALER ,Health care ,Medicine and Health Sciences ,Immunology and Allergy ,Medicine ,TECHNOLOGY ,030223 otorhinolaryngology ,Total quality management ,Science & Technology ,ARIA ,business.industry ,Digital transformation ,GENERATION CARE PATHWAYS ,ALLERGIC RHINITIS ,CHRONIC RESPIRATORY-DISEASES ,030228 respiratory system ,General partnership ,GA(2)LEN ,business ,Life Sciences & Biomedicine ,ASTHMA MULTIMORBIDITY ,Health care quality - Abstract
The reference sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) were renewed in 2019. The DG Santé good practice Mobile Airways Sentinel networK was reviewed to meet the objectives of the EIP on AHA. It included 1) Management of care process, 2) Blueprint of digital transformation, 3) EIP on AHA, innovation to market, 4) Community for monitoring and assessment framework, 5) Political, organizational, technological and financial readiness, 6) Contributing to European co-operation and transferability, 7) Delivering evidence of impact against the triple win approach, 8) Contribution to the European Digital Transformation of Health and Care and 9) scale of demonstration and deployment of innovation. ispartof: ALLERGY ASTHMA & IMMUNOLOGY RESEARCH vol:12 issue:2 pages:238-258 ispartof: location:Korea (South) status: published
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- 2020
40. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper
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Pfaar, O. Klimek, L. Jutel, M. Akdis, C.A. Bousquet, J. Breiteneder, H. Chinthrajah, S. Diamant, Z. Eiwegger, T. Fokkens, W.J. Fritsch, H.-W. Nadeau, K.C. O’Hehir, R.E. O’Mahony, L. Rief, W. Sampath, V. Schedlowski, M. Torres, M.J. Traidl-Hoffmann, C. Wang, D.Y. Zhang, L. Bonini, M. Brehler, R. Brough, H.A. Chivato, T. Del Giacco, S.R. Dramburg, S. Gawlik, R. Gelincik, A. Hoffmann-Sommergruber, K. Hox, V. Knol, E.F. Lauerma, A. Matricardi, P.M. Mortz, C.G. Ollert, M. Palomares, O. Riggioni, C. Schwarze, J. Skypala, I. Untersmayr, E. Walusiak-Skorupa, J. Ansotegui, I.J. Bachert, C. Bedbrook, A. Bosnic-Anticevich, S. Brussino, L. Canonica, G.W. Cardona, V. Carreiro-Martins, P. Cruz, A.A. Czarlewski, W. Fonseca, J.A. Gotua, M. Haahtela, T. Ivancevich, J.C. Kuna, P. Kvedariene, V. Larenas-Linnemann, D.E. Abdul Latiff, A.H. Mäkelä, M. Morais-Almeida, M. Mullol, J. Naclerio, R. Ohta, K. Okamoto, Y. Onorato, G.L. Papadopoulos, N.G. Patella, V. Regateiro, F.S. Samoliński, B. Suppli Ulrik, C. Toppila-Salmi, S. Valiulis, A. Ventura, M.-T. Yorgancioglu, A. Zuberbier, T. Agache, I.
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education - Abstract
Background: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. Method: The scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. Results: Based on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. Conclusions: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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- 2021
41. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK-air®
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Sousa-Pinto, B. Eklund, P. Pfaar, O. Klimek, L. Zuberbier, T. Czarlewski, W. Bédard, A. Bindslev-Jensen, C. Bedbrook, A. Bosnic-Anticevich, S. Brussino, L. Cardona, V. Cruz, A.A. de Vries, G. Devillier, P. Fokkens, W.J. Fuentes-Pérez, J.M. Gemicioğlu, B. Haahtela, T. Huerta-Villalobos, Y.R. Ivancevich, J.C. Kull, I. Kuna, P. Kvedariene, V. Larenas Linnemann, D.E. Laune, D. Makris, M. Melén, E. Morais-Almeida, M. Mösges, R. Mullol, J. O'Hehir, R.E. Papadopoulos, N.G. Pereira, A.M. Prokopakis, E.P. Psarros, F. Regateiro, F.S. Reitsma, S. Samolinski, B. Scichilone, N. da Silva, J. Stellato, C. Todo-Bom, A. Tomazic, P.V. Salmi, S.T. Valero, A. Valiulis, A. Valovirta, E. van Eerd, M. Ventura, M.T. Yorgancioglu, A. Basagaña, X. Antó, J.M. Bousquet, J. Fonseca, J.A.
- Abstract
Background: MASK-air® is an app that supports allergic rhinitis patients in disease control. Users register daily allergy symptoms and their impact on activities using visual analog scales (VASs). We aimed to assess the concurrent validity, reliability, and responsiveness of these daily VASs. Methods: Daily monitoring VAS data were assessed in MASK-air® users with allergic rhinitis. Concurrent validity was assessed by correlating daily VAS values with those of the EuroQol-5 Dimensions (EQ-5D) VAS, the Control of Allergic Rhinitis and Asthma Test (CARAT) score, and the Work Productivity and Activity Impairment Allergic Specific (WPAI-AS) Questionnaire (work and activity impairment scores). Intra-rater reliability was assessed in users providing multiple daily VASs within the same day. Test–retest reliability was tested in clinically stable users, as defined by the EQ-5D VAS, CARAT, or “VAS Work” (i.e., VAS assessing the impact of allergy on work). Responsiveness was determined in users with two consecutive measurements of EQ-5D-VAS or “VAS Work” indicating clinical change. Results: A total of 17,780 MASK-air® users, with 317,176 VAS days, were assessed. Concurrent validity was moderate–high (Spearman correlation coefficient range: 0.437–0.716). Intra-rater reliability intraclass correlation coefficients (ICCs) ranged between 0.870 (VAS assessing global allergy symptoms) and 0.937 (VAS assessing allergy symptoms on sleep). Test–retest reliability ICCs ranged between 0.604 and 0.878—“VAS Work” and “VAS asthma” presented the highest ICCs. Moderate/large responsiveness effect sizes were observed—the sleep VAS was associated with lower responsiveness, while the global allergy symptoms VAS demonstrated higher responsiveness. Conclusion: In MASK-air®, daily monitoring VASs have high intra-rater reliability and moderate–high validity, reliability, and responsiveness, pointing to a reliable measure of symptom loads. © 2021 The Authors. Clinical and Translational Allergy published by John Wiley and Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
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- 2021
42. Management of anaphylaxis due to COVID-19 vaccines in the elderly
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Bousquet, J. Agache, I. Blain, H. Jutel, M. Ventura, M.T. Worm, M. Del Giacco, S. Benetos, A. Bilo, B.M. Czarlewski, W. Abdul Latiff, A.H. Al-Ahmad, M. Angier, E. Annesi-Maesano, I. Atanaskovic-Markovic, M. Bachert, C. Barbaud, A. Bedbrook, A. Bennoor, K.S. Berghea, E.C. Bindslev-Jensen, C. Bonini, S. Bosnic-Anticevich, S. Brockow, K. Brussino, L. Camargos, P. Canonica, G.W. Cardona, V. Carreiro-Martins, P. Carriazo, A. Casale, T. Caubet, J.-C. Cecchi, L. Cherubini, A. Christoff, G. Chu, D.K. Cruz, A.A. Dokic, D. El-Gamal, Y. Ebisawa, M. Eberlein, B. Farrell, J. Fernandez-Rivas, M. Fokkens, W.J. Fonseca, J.A. Gao, Y. Gavazzi, G. Gawlik, R. Gelincik, A. Gemicioğlu, B. Gotua, M. Guérin, O. Haahtela, T. Hoffmann-Sommergruber, K. Hoffmann, H.J. Hofmann, M. Hrubisko, M. Illario, M. Irani, C. Ispayeva, Z. Ivancevich, J.C. Julge, K. Kaidashev, I. Khaitov, M. Knol, E. Kraxner, H. Kuna, P. Kvedariene, V. Lauerma, A. Le, L.T.T. Le Moing, V. Levin, M. Louis, R. Lourenco, O. Mahler, V. Martin, F.C. Matucci, A. Milenkovic, B. Miot, S. Montella, E. Morais-Almeida, M. Mortz, C.G. Mullol, J. Namazova-Baranova, L. Neffen, H. Nekam, K. Niedoszytko, M. Odemyr, M. O’Hehir, R.E. Okamoto, Y. Ollert, M. Palomares, O. Papadopoulos, N.G. Panzner, P. Passalacqua, G. Patella, V. Petrovic, M. Pfaar, O. Pham-Thi, N. Plavec, D. Popov, T.A. Recto, M.T. Regateiro, F.S. Reynes, J. Roller-Winsberger, R.E. Rolland, Y. Romano, A. Rondon, C. Rottem, M. Rouadi, P.W. Salles, N. Samolinski, B. Santos, A.F. S Sarquis, F. Sastre, J. M. G. A. Schols, J. Scichilone, N. Sediva, A. Shamji, M.H. Sheikh, A. Skypala, I. Smolinska, S. Sokolowska, M. Sousa-Pinto, B. Sova, M. Stelmach, R. Sturm, G. Suppli Ulrik, C. Todo-Bom, A.M. Toppila-Salmi, S. Tsiligianni, I. Torres, M. Untersmayr, E. Urrutia Pereira, M. Valiulis, A. Vitte, J. Vultaggio, A. Wallace, D. Walusiak-Skorupa, J. Wang, D.-Y. Waserman, S. Yorgancioglu, A. Yusuf, O.M. Zernotti, M. Zidarn, M. Chivato, T. Akdis, C.A. Zuberbier, T. Klimek, L.
- Abstract
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients. © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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- 2021
43. Oral corticosteroids stewardship for asthma in adults and adolescents: A position paper from the Thoracic Society of Australia and New Zealand
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Blakey, J, Chung, LP, McDonald, VM, Ruane, L, Gornall, J, Barton, C, Bosnic-Anticevich, S, Harrington, J, Hew, M, Holland, AE, Hopkins, T, Jayaram, L, Reddel, H, Upham, JW, Gibson, PG, Bardin, P, Blakey, J, Chung, LP, McDonald, VM, Ruane, L, Gornall, J, Barton, C, Bosnic-Anticevich, S, Harrington, J, Hew, M, Holland, AE, Hopkins, T, Jayaram, L, Reddel, H, Upham, JW, Gibson, PG, and Bardin, P
- Abstract
Oral corticosteroids (OCS) are frequently used for asthma treatment. This medication is highly effective for both acute and chronic diseases, but evidence indicates that indiscriminate OCS use is common, posing a risk of serious side effects and irreversible harm. There is now an urgent need to introduce OCS stewardship approaches, akin to successful initiatives that optimized appropriate antibiotic usage. The aim of this TSANZ (Thoracic Society of Australia and New Zealand) position paper is to review current knowledge pertaining to OCS use in asthma and then delineate principles of OCS stewardship. Recent evidence indicates overuse and over-reliance on OCS for asthma and that doses >1000 mg prednisolone-equivalent cumulatively are likely to have serious side effects and adverse outcomes. Patient perspectives emphasize the detrimental impacts of OCS-related side effects such as weight gain, insomnia, mood disturbances and skin changes. Improvements in asthma control and prevention of exacerbations can be achieved by improved inhaler technique, adherence to therapy, asthma education, smoking cessation, multidisciplinary review, optimized medications and other strategies. Recently, add-on therapies including novel biological agents and macrolide antibiotics have demonstrated reductions in OCS requirements. Harm reduction may also be achieved through identification and mitigation of predictable adverse effects. OCS stewardship should entail greater awareness of appropriate indications for OCS prescription, risk-benefits of OCS medications, side effects, effective add-on therapies and multidisciplinary review. If implemented, OCS stewardship can ensure that clinicians and patients with asthma are aware that OCS should not be used lightly, while providing reassurance that asthma can be controlled in most people without frequent use of OCS.
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- 2021
44. Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-Based Cohort Study from UK Primary Care
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Busby, J, Price, D, Al-Lehebi, R, Bosnic-Anticevich, S, van Boven, JF, Emmanuel, B, FitzGerald, JM, Gaga, M, Hansen, S, Hew, M, Iwanaga, T, Larenas-Linnemann, D, Mahboub, B, Mitchell, P, Morrone, D, Pham, J, Porsbjerg, C, Roche, N, Wang, E, Eleangovan, N, Heaney, LG, Busby, J, Price, D, Al-Lehebi, R, Bosnic-Anticevich, S, van Boven, JF, Emmanuel, B, FitzGerald, JM, Gaga, M, Hansen, S, Hew, M, Iwanaga, T, Larenas-Linnemann, D, Mahboub, B, Mitchell, P, Morrone, D, Pham, J, Porsbjerg, C, Roche, N, Wang, E, Eleangovan, N, and Heaney, LG
- Abstract
INTRODUCTION: Asthma morbidity and health-care utilization are known to exhibit a steep socioeconomic gradient. Further investigation into the modulators of this effect is required to identify potentially modifiable factors. METHODS: We identified a cohort of patients with asthma from the Optimum Patient Care Research Database (OPCRD). We compared demographics, clinical variables, and health-care utilization by quintile of the UK 2011 Indices of Multiple Deprivation based on the location of the patients' general practice. Multivariable analyses were conducted using generalized linear models adjusting for year, age, and sex. We conducted subgroup analyses and interaction tests to investigate the impact of deprivation by age, sex, ethnicity, and treatment step. RESULTS: Our analysis included 127,040 patients with asthma. Patients from the most deprived socio-economic status (SES) quintile were more likely to report uncontrolled disease (OR: 1.54, 95% CI: 1.16, 2.05) and to have an exacerbation during follow-up (OR: 1.27, 95% CI: 1.13, 1.42) than the least deprived quintile. They had higher blood eosinophils (ratio: 1.03; 95% CI: 1.00, 1.06) and decreased peak flow (ratio: 0.95, 95% CI: 0.94, 0.97) when compared to those in the least deprived quintile. The effect of deprivation on asthma control was greater among those aged over 75 years (OR = 1.81, 95% CI: 1.20, 2.73) compared to those aged less than 35 years (OR: 1.22, 95% CI: 0.85, 1.74; pinteraction=0.019). Similarly, socioeconomic disparities in exacerbations were larger among those from ethnic minority groups (OR: 1.94, 95% CI: 1.40, 2.68) than white patients (OR: 1.24, 95% CI: 1.10, 1.39; pinteraction=0.012). CONCLUSION: We found worse disease control and increased exacerbation rates among patients with asthma from more deprived areas. There was evidence that the magnitude of socioeconomic disparities was elevated among older patients and those from ethnic minority groups. The drivers of these differences requir
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- 2021
45. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper
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CTI Research, CTI, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, O, Klimek, L, Jutel, M, Akdis, C A, Bousquet, J, Breiteneder, H, Chinthrajah, S, Diamant, Z, Eiwegger, T, Fokkens, W J, Fritsch, H W, Nadeau, K C, O'Hehir, R E, O'Mahony, L, Rief, W, Sampath, V, Schedlowski, M, Torres, M, Traidl-Hoffmann, C, Wang, D Y, Zhang, L, Bonini, M, Brehler, R, Brough, H A, Chivato, T, Del Giacco, S, Dramburg, S, Gawlik, R, Gelincik, A, Hoffmann-Sommergruber, K, Hox, V, Knol, E, Lauerma, A, Matricardi, P M, Mortz, C G, Ollert, M, Palomares, O, Riggioni, C, Schwarze, J, Skypala, I, Untersmayr, S, Walusiak-Skorupa, J, Ansotegui, I, Bachert, C, Bedbrook, A, Bosnic-Anticevich, S, Brussino, L, Canonica, G W, Cardona, V, Carreiro-Martins, P, Cruz, A A, Czarlewski, W, Fonseca, J A, Gotua, M, Haatela, T, Ivancevich, J C, Kuna, P, Kvedariene, V, Larenas-Linnemann, D, Latiff, A, Morais-Almeida, M, Mullol, J, Naclerio, R, Ohta, K, Okamoto, Y, Onorato, G L, Papadopoulos, N G, Patella, V, Regateiro, F S, Samolinski, B, Suppli Ulrik, C, Toppila-Salmi, S, Valiulis, A, Ventura, M T, Yorgancioglu, A, Zuberbier, T, Agache, I, CTI Research, CTI, MS Dermatologie/Allergologie, Infection & Immunity, Pfaar, O, Klimek, L, Jutel, M, Akdis, C A, Bousquet, J, Breiteneder, H, Chinthrajah, S, Diamant, Z, Eiwegger, T, Fokkens, W J, Fritsch, H W, Nadeau, K C, O'Hehir, R E, O'Mahony, L, Rief, W, Sampath, V, Schedlowski, M, Torres, M, Traidl-Hoffmann, C, Wang, D Y, Zhang, L, Bonini, M, Brehler, R, Brough, H A, Chivato, T, Del Giacco, S, Dramburg, S, Gawlik, R, Gelincik, A, Hoffmann-Sommergruber, K, Hox, V, Knol, E, Lauerma, A, Matricardi, P M, Mortz, C G, Ollert, M, Palomares, O, Riggioni, C, Schwarze, J, Skypala, I, Untersmayr, S, Walusiak-Skorupa, J, Ansotegui, I, Bachert, C, Bedbrook, A, Bosnic-Anticevich, S, Brussino, L, Canonica, G W, Cardona, V, Carreiro-Martins, P, Cruz, A A, Czarlewski, W, Fonseca, J A, Gotua, M, Haatela, T, Ivancevich, J C, Kuna, P, Kvedariene, V, Larenas-Linnemann, D, Latiff, A, Morais-Almeida, M, Mullol, J, Naclerio, R, Ohta, K, Okamoto, Y, Onorato, G L, Papadopoulos, N G, Patella, V, Regateiro, F S, Samolinski, B, Suppli Ulrik, C, Toppila-Salmi, S, Valiulis, A, Ventura, M T, Yorgancioglu, A, Zuberbier, T, and Agache, I
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- 2021
46. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
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Bousquet J., Arnavielhe S., Bedbrook A., Bewick M., Laune D., Mathieu-dupas E., Murray R., Onorato G.L., Pepin J.L., Picard R., Portejoie F., Costa E., Fonseca J., Lourenco O., Morais-Almeida M., Todo-bom A., Cruz A.A., Silva J.D., Serpa F.S., Illario M., Menditto E., Cecchi L., Monti R., Napoli L., Ventura M.T., De Feo G., Larenas-linnemann D., Fuentes Perez M., Huerta Villabolos Y.R., Rivero-yeverino D., Rodriguez-zagal E., Amat F., Annesi-maesano I., Bosse I., Demoly P., Devillier P., Fontaine J.F., Just J., Kuna T.P., Samolinski B., Valiulis A., Emuzyte R., Kvedariene V., Ryan D., Sheikh A., Schmidt-grendelmeier P., Klimek L., Pfaar O., Bergmann K.C., Mosges R., Zuberbier T., Roller-wirnsberger R.E., Tomazic P., Fokkens W.J., Chavannes N.H., Reitsma S., Anto J.M., Cardona V., Dedeu T., Mullol J., Haahtela T., Salimaki J., Toppila-Salmi S., Valovirta E., Gemicioglu B., Yorgancioglu A., Papadopoulos N., Prokopakis E.P., Bosnic-anticevich S., O'hehir R., Ivancevich J.C., Neffen H., Zernotti E., Kull I., Melen E., Wickman M., Bachert C., Hellings P., Palkonen S., Bindslev-jensen C., Eller E., Waserman S., Sova M., De Vries G., van Eerd M., Agache I., Casale T., Dykewickz M., Naclerio R.N., Okamoto Y., Wallace D.V., Hellings P.W., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Ansotegui I.J., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bateman E.D., Bedolla-Barajas M., Beghe B., Bel E.H., Bennoor K.S., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bosnic-Anticevich C.S., Bouchard J., Boulet L.P., Bourret R., Bousquet P.J., Braido F., Briedis V., Brightling C.E., Brozek J., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Canonica G.W., Carlsen K.H., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Cepeda A.M., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Correia de Sousa J., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Czarlewski W., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., De Carlo G., de Fatima Emerson M., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Dykewicz M.S., El-Gamal Y., Eklund P., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Fonseca J.A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Guzman M.A., Hajjam J., Hernandez L., Hourihane J.O.'.B., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kaidashev I., Kalayci O., Kalyoncu A.F., Karjalainen J., Kardas P., Keil T., Keith P.K., Khaitov M., Khaltaev N., Kleine-Tebbe J., Kowalski M.L., Kuitunen M., Kuna P., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Le L.T.T., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Mahboub B., Maier D., Mair A., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Milenkovic B., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Naclerio R., Nadif R., Nalin M., Namazova-Baranova L., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Novellino E., Nyembue T.D., O'hehir R.E., Odzhakova C., Ohta K., Okubo K., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Panzner P., Papadopoulos N.G., Park H.S., Papi A., Passalacqua G., Paulino E., Pawankar R., Pedersen S., Pereira A.M., Persico M., Phillips J., Pigearias B., Pin I., Pitsios C., Plavec D., Pohl W., Popov T.A., Potter P., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Rajabian-Soderlund R., Ribeirinho I., Rimmer J., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rolla G., Romano M., Rosado-Pinto J., Rosario N., Rottem M., Sagara H., Sanchez-Borges M., Sastre-Dominguez J., Scadding G.K., Schunemann H.J., Scichilone N., Schmid-Grendelmeier P., Shamai S., Sierra M., Simons F.E.R., Siroux V., Sisul J.C., Skrindo I., Sole D., Somekh D., Sondermann M., Sooronbaev T., Sorensen M., Sorlini M., Spranger O., Stellato C., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., To T., Tomazic P.V., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., Valero A., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi G., Vicheva D., Vontetsianos T., Wagenmann M., Walker S., Wallace D., Wang D.Y., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zhang L., Zhong N., Zernotti M.E., Zidarn M., Zubrinich C., Zurkuhlen A., [et al.], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (Sysdiag), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Istituto di Astrofisica Spaziale, Universidade de Lisboa (ULISBOA), University of Beira Interior [Portugal] (UBI), University of Coimbra [Portugal] (UC), 'Federico II' University of Naples Medical School, University of Salerno (UNISA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Montpellier, Département pneumologie et 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(INSERM), Service d'Allergologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Medical University of Łódź (MUL), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Karl-Franzens-Universität [Graz, Autriche], Leiden University Medical Center (LUMC), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, IMIM-Hospital del Mar, Generalitat de Catalunya, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), University of Helsinki, The University of Sydney, University of Amsterdam [Amsterdam] (UvA), University of South Florida [Tampa] (USF), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Kyomed, iQ4U consultants Ltd, MedScript Ltd, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2 ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Conseil général de l'économie, de l'industrie et des technologies (CGEIET), Ministère de l'Economie, des Finances et de l'Industrie, The University of Tokyo (UTokyo), Federazione Italiana Medici di Medicina Generale (FIMMG), uBibliorum, Bousquet, J., Arnavielhe, S., Bedbrook, A., Bewick, M., Laune, D., Mathieu-Dupas, E., Murray, R., Onorato, G. L., Pépin, J. L., Picard, R., Portejoie, F., Costa, E., Fonseca, J., Lourenço, O., Morais-Almeida, M., Todo-Bom, A., Cruz, A. A., Da Silva, J., Serpa, F. S., Illario, M., Menditto, E., Cecchi, L., Monti, R., Napoli, L., Ventura, M. T., De Feo, G., Larenas-Linnemann, D., Fuentes Perez, M., Huerta Villabolos, Y. R., Rivero-Yeverino, D., Rodriguez-Zagal, E., Amat, F., Annesi-Maesano, I., Bosse, I., Demoly, P., Devillier, P., Fontaine, J. F., Just, J., Kuna, T. P., Samolinski, B., Valiulis, A., Emuzyte, R., Kvedariene, V., Ryan, D., Sheikh, A., Schmidt-Grendelmeier, P., Klimek, L., Pfaar, O., Bergmann, K. C., Mösges, R., Zuberbier, T., Roller-Wirnsberger, R. E., Tomazic, P., Fokkens, W. J., Chavannes, N. H., Reitsma, S., Anto, J. M., Cardona, V., Dedeu, T., Mullol, J., Haahtela, T., Salimäki, J., Toppila-Salmi, S., Valovirta, E., Gemicioǧlu, B., Yorgancioglu, A., Papadopoulos, N., Prokopakis, E. P., Bosnic-Anticevich, S., O'Hehir, R., Ivancevich, J. C., Neffen, H., Zernotti, E., Kull, I., Melen, E., Wickman, M., Bachert, C., Hellings, P., Palkonen, S., Bindslev-Jensen, C., Eller, E., Waserman, S., Sova, M., De Vries, G., Van Eerd, M., Agache, I., Casale, T., Dykewickz, M., Naclerio, R. N., Okamoto, Y., Wallace, D. V., Universidade do Minho, Bousquet J., Arnavielhe S., Bedbrook A., Bewick M., Laune D., Mathieu-dupas E., Murray R., Onorato G.L., Pepin J.L., Picard R., Portejoie F., Costa E., Fonseca J., Lourenco O., Morais-Almeida M., Todo-bom A., Cruz A.A., Silva J.D., Serpa F.S., Illario M., Menditto E., Cecchi L., Monti R., Napoli L., Ventura M.T., De Feo G., Larenas-linnemann D., Fuentes Perez M., Huerta Villabolos Y.R., Rivero-yeverino D., Rodriguez-zagal E., Amat F., Annesi-maesano I., Bosse I., Demoly P., Devillier P., Fontaine J.F., Just J., Kuna T.P., Samolinski B., Valiulis A., Emuzyte R., Kvedariene V., Ryan D., Sheikh A., Schmidt-grendelmeier P., Klimek L., Pfaar O., Bergmann K.C., Mosges R., Zuberbier T., Roller-wirnsberger R.E., Tomazic P., Fokkens W.J., Chavannes N.H., Reitsma S., Anto J.M., Cardona V., Dedeu T., Mullol J., Haahtela T., Salimaki J., Toppila-Salmi S., Valovirta E., Gemicioglu B., Yorgancioglu A., Papadopoulos N., Prokopakis E.P., Bosnic-anticevich S., O'hehir R., Ivancevich J.C., Neffen H., Zernotti E., Kull I., Melen E., Wickman M., Bachert C., Hellings P., Palkonen S., Bindslev-jensen C., Eller E., Waserman S., Sova M., De Vries G., van Eerd M., Agache I., Casale T., Dykewickz M., Naclerio R.N., Okamoto Y., Wallace D.V., Hellings P.W., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Ansotegui I.J., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bateman E.D., Bedolla-Barajas M., Beghe B., Bel E.H., Bennoor K.S., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bosnic-Anticevich C.S., Bouchard J., Boulet L.P., Bourret R., Bousquet P.J., Braido F., Briedis V., Brightling C.E., Brozek J., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Canonica G.W., Carlsen K.H., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Cepeda A.M., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Correia de Sousa J., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Czarlewski W., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., De Carlo G., de Fatima Emerson M., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Dykewicz M.S., El-Gamal Y., Eklund P., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Fonseca J.A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Guzman M.A., Hajjam J., Hernandez L., Hourihane J.O.'.B., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kaidashev I., Kalayci O., Kalyoncu A.F., Karjalainen J., Kardas P., Keil T., Keith P.K., Khaitov M., Khaltaev N., Kleine-Tebbe J., Kowalski M.L., Kuitunen M., Kuna P., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Le L.T.T., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Mahboub B., Maier D., Mair A., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Milenkovic B., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Naclerio R., Nadif R., Nalin M., Namazova-Baranova L., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Novellino E., Nyembue T.D., O'hehir R.E., Odzhakova C., Ohta K., Okubo K., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Panzner P., Papadopoulos N.G., Park H.S., Papi A., Passalacqua G., Paulino E., Pawankar R., Pedersen S., Pereira A.M., Persico M., Phillips J., Pigearias B., Pin I., Pitsios C., Plavec D., Pohl W., Popov T.A., Potter P., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Rajabian-Soderlund R., Ribeirinho I., Rimmer J., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rolla G., Romano M., Rosado-Pinto J., Rosario N., Rottem M., Sagara H., Sanchez-Borges M., Sastre-Dominguez J., Scadding G.K., Schunemann H.J., Scichilone N., Schmid-Grendelmeier P., Shamai S., Sierra M., Simons F.E.R., Siroux V., Sisul J.C., Skrindo I., Sole D., Somekh D., Sondermann M., Sooronbaev T., Sorensen M., Sorlini M., Spranger O., Stellato C., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., To T., Tomazic P.V., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., Valero A., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi G., Vicheva D., Vontetsianos T., Wagenmann M., Walker S., Wallace D., Wang D.Y., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zhang L., Zhong N., Zernotti M.E., Zidarn M., Zubrinich C., Zurkuhlen A., Internal Medicine, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie
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Allergy ,HEALTH-ORGANIZATION ,IMPACT ,Respiratory Medicine and Allergy ,[SDV]Life Sciences [q-bio] ,Allergic Rhinitis and its Impact on Asthma - ARIA ,Review ,MASK - Mobile Airways Sentinel networK ,0302 clinical medicine ,610 Medical sciences Medicine ,App ,ARIA ,Asthma ,Care pathways ,MASK ,mHealth ,Rhinitis ,Immunology and Allergy ,Immunology ,Pulmonary and Respiratory Medicine ,Health care ,Medicine and Health Sciences ,030212 general & internal medicine ,Android (operating system) ,Rinitis ,Rhiniti ,ComputingMilieux_MISCELLANEOUS ,Lungmedicin och allergi ,PRODUCTIVITY ,3. Good health ,ALLERGIC RHINITIS ,Rinite ,Medical emergency ,Life Sciences & Biomedicine ,STRATEGIES ,MASK study group ,MEDLINE ,K-ANONYMITY ,Pharmacy ,[object Object] ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,VALIDATION ,MACVIA-ARIA ,03 medical and health sciences ,medicine ,Mobile technology ,TECHNOLOGY ,App -MASK ,Asma ,Care pathway ,Science & Technology ,business.industry ,Settore MED/09 - MEDICINA INTERNA ,Correction ,Guideline ,RC581-607 ,medicine.disease ,030228 respiratory system ,Immunologic diseases. Allergy ,business ,EUROPEAN COUNTRIES ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary., UZ Leuven -Universitaire Ziekenhuizen Leuven, KU Leuven(GA2LEN), info:eu-repo/semantics/publishedVersion
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- 2018
47. Interprofessional care: Building on experience, opportunities, and policy
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Bosnic-Anticevich, S. Z., Saini, B., Krass, I., and Armour, C. L.
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- 2014
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48. Are Australian Undergraduate Pharmacy Students Reflective Learners, and Does This Contribute to Greater Academic Success?
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Tsingos, C., Bosnic-Anticevich, S., and Smith, L.
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- 2014
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49. More than respect, role definition and resources: the underlying facilitators to collaborative relationships in health care
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Bosnic-Anticevich, S. Z., Cvetkovski, B., and Armour, C. L.
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- 2014
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50. Adherence to treatment in allergic rhinitis using mobile technology. the mask study
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Costa-Dominguez, Al Courbis, Cox, L, Crescenzo, M, Custovic, A, Dahlen, SE, D'Amato, Dario, C, da Silva, J, Dauvilliers, Y, Darsow, U, De Blay, F, De Carlo, G, Dedeu, T, Emerson, MDF, De Martino, B, Rubina, NPM, Deleanu, D, Demoly, P, Denburg, J, Ercolano, SDC, Di Carluccio, N, Didier, A, Dokic, D, Dominguez-Silva, MG, Douagui, H, Dray, G, Dubakiene, R, Durham, SR, Du Toit, G, Dykewicz, MS, El-Gamal, Y, Eklund, P, Emuzyte, R, Farrell, J, Farsi, A, De Mello, JF, Ferrero, J, Fink-Wagner, A, Fiocchi, A, Fok-Kens, WJ, Forti, S, Fuentes-Perez, JM, Galvez-Romero, JL, Gamkrelidze, A, Garcia-Aymerich, J, Garcia-Cobas, CY, Garcia-Cruz, MH, Genova, S, Christoff, G, Gereda, JE, Van Wijk, RG, Gomez, RM, Gomez-Vera, J, Diaz, SG, Gotua, M, Grisle, I, Guidacci, M, Guldemond, N, Gutter, Z, Guzman, M, Hajjam, J, Hernandez, L, Houri-Hane, J, Huerta-Villalobos, YR, Humbert, M, Iaccarino, G, Illario, M, Ispayeva, Z, Jares, E, Jassem, E, Johnston, SL, Joos, G, Jung, KS, Just, J, Jutel, M, Kaidashev, I, Kalyoncu, AF, Karjalainen, J, Kardas, P, Keith, PK, Khaitov, M, Khaltaev, N, Kleine-Tebbe, J, Kowalski, ML, Kuitunen, M, Kull, I, Kupczyk, M, Krzych-Falta, E, Lacwik, P, Lauri, D, Lavrut, J, L, TT, Lessa, M, Levato, G, Li, J, Lieberman, P, Liplec, A, Lipworth, B, Carlsen, KCL, Louis, R, Lourenco, O, Luna-Pech, JA, Magnan, A, Mahboub, B, Maier, D, Majer, I, Mandajieva, E, Manning, P, Keenoy, EDM, Marshall, GD, Masjedi, MR, Maspero, JF, Mathieu-Dupas, E, Campos, JJM, Al Matos, Maurer, M, Mavale-Manuel, S, Mayora, O, Medina-Avalos, MA, Melo-Gomes, E, Meltzer, E, Mercier, J, Miculinic, N, Mihaltan, F, Milenkovic, B, Moda, G, Mogica-Martinez, MD, Mohammad, Y, Momas, I, Monte-Fort, S, Monti, R, Bogado, DM, Morato-Castro, Mota-Pinto, A, Santo, PM, Munter, L, Muraro, A, Murray, R, Naclerio, R, Nadif, R, Nalin, M, Napoli, L, Namazova-Baranova, L, Neffen, H, Niedeberger, V, Nekam, K, Neou, A, Nieto, A, Nogueira-Silva, L, Nogues, M, Nyembue, T, O'Hehir, R, Odzhakova, C, Ohta, K, Okamoto, Y, Okubo, K, Onorato, GL, Cisneros, MO, Ouedraogo, S, Pali-Scholl, I, Palkonen, S, Panzner, P, Park, HS, Papi, A, Passalacqua, G, Paulino, E, Pawankar, R, Pedersen, S, Pepin, JL, Persico, M, Phillips, J, Picard, R, Pigearias, B, Pin, I, Pitsios, C, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Potter, P, Pozzi, AC, Price, D, Puy, R, Pugin, B, Ross, REP, Przemecka, M, Rabe, KF, Raciborski, F, Raja-Bian-Soderlund, R, Ribeirinho, I, Rimmer, J, Riv-Ero-Yeverino, D, Rizzo, JA, Rizzo, MC, Robalo-Cordeiro, C, Rodenas, F, Rodo, X, Gonzalez, MR, Rodriguez-Manas, L, Rolland, C, Valle, SR, Rodriguez, MR, Romano, A, Rodriguez-Zagal, E, Rolla, G, Romano, M, Rosado-Pinto, J, Rosario, N, Rottem, M, Sagara, H, Salimaki, J, Sanchez-Borges, M, Sastre-Dominguez, J, Scadding, GK, Schunemann, HJ, Scichilone, N, Schmid-Grendelmeier, P, Serpa, FS, Shamai, S, Sierra, M, Simons, FER, Sir-Oux, V, Sisul, JC, Skrindo, I, Sole, D, Somekh, D, Sonder-Mann, M, Sooronbaev, T, Sova, M, Sorensen, M, Sorlini, M, Spranger, O, Stelmach, R, Stukas, R, Sunyer, J, Strozek, J, Szylling, A, Tebyrica, J, Thibaudon, M, To, T, Todo-Bom, A, Trama, U, Triggiani, M, Ulrik, CS, Urrutia-Pereira, M, Valenta, R, Valero, A, Valovirta, E, Van Eerd, M, Van Ganse, E, Van Hague, M, Vandenplas, O, Ventura, MT, Vezzani, G, Vasankari, T, Vatrella, A, Verissimo, MT, Viart, F, Viegi, G, Vicheva, D, Vontetsianos, T, Wagenmann, M, Walker, S, Wallace, D, Wang, DY, Waserman, S, Werfel, T, Westman, M, Williams, DM, Williams, S, Wilson, N, Wright, J, Wroczynski, P, Yakovliev, P, Yawn, BP, Yiallouros, PK, Yorgancioglu, A, Yusuf, OM, Zar, HJ, Zhang, L, Zhong, N, Zernotti, ME, Zhanat, I, Zidarn, M, Zubrinich, C, Zurkuhlen, A, MASK Grp, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Department of Dermatology, Allergology and Venereology, University of Helsinki, Clinicum, Children's Hospital, HUS Children and Adolescents, HUS Inflammation Center, et. al., Universidade do Minho, Internal Medicine, Health Services Management & Organisation (HSMO), Ear, Nose and Throat, AII - Inflammatory diseases, Kyomed, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Università degli Studi di Salerno (UNISA), Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto, Institute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Cerrahpasa Faculty of Medicine, Istanbul University, Hacettepe University = Hacettepe Üniversitesi, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department for Molecular Biomedical Research, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Department of Otorhinolaryngology, Head and Neck Surgery, Eskisehir Osmangazi University, Instituto de Biologia Molecular e Celular (IBMC), Laboratoire de Génie Informatique et d'Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), UCB Pharma, Colombes, Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Dermatology and Allergy Centre, Odense University Hospital, Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Society for Otorhinolaryngology HNS, Medical University of Łódź (MUL), Vilnius University [Vilnius], Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Coimbra [Portugal] (UC), 'Federico II' University of Naples Medical School, Transverse group for research in primary care [Barcelona], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Naples Federico II, University Hospital Mannheim, Allergy and Respiratory Research Group, University of Edinburgh, Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw - Poland, Asthma UK Centre for Applied Research [Edinburgh, U.K.], University of Edinburgh-Usher Institute of Population Health Sciences and Informatics [Edinburgh, U.K.], Vilnius University Clinic of Children's Diseases, Sachs’ Children and Youth Hospital [Stockholm, Sweden], Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Menditto, E, Costa, E, Midão, L, Bosnic-Anticevich, S, Novellino, E, Bialek, S, Briedis, V, Mair, A, Rajabian-Soderlund, R, Arnavielhe, S, Bedbrook, A, Czarlewski, W, Annesi-Maesano, I, Anto, Jm, Devillier, P, De Vries, G, Keil, T, Sheikh, A, Orlando, V, Larenas-Linnemann, D, Cecchi, L, De Feo, G, Illario, M, Stellato, C, Fonseca, J, Malva, J, Morais-Almeida, M, Pereira, Am, Todo-Bom, A, Kvedariene, V, Valiulis, A, Bergmann, Kc, Klimek, L, Mösges, R, Pfaar, O, Zuberbier, T, Cardona, V, Mullol, J, Papadopoulos, Ng, Prokopakis, Ep, Bewick, M, Ryan, D, Roller-Wirnsberger, Re, Tomazic, Pv, Cruz, Aa, Kuna, P, Samolinski, B, Fokkens, Wj, Reitsma, S, Bosse, I, Fontaine, Jf, Laune, D, Haahtela, T, Toppila-Salmi, S, Bachert, C, Hellings, Pw, Melén, E, Wickman, M, Bindslev-Jensen, C, Eller, E, O'Hehir, Re, Cingi, C, Gemicioğlu, B, Kalayci, O, Ivancevich, Jc, Bousquet, J, and Iaccarino, Guido
- Subjects
0301 basic medicine ,Male ,Allergy ,Medicina Básica [Ciências Médicas] ,CONTROLLER MEDICATION ,adherence ,mHealth ,mobile technology ,observational study ,rhinitis ,treatment ,THERAPY ,Medical and Health Sciences ,Medical Records ,DISEASE ,0302 clinical medicine ,Surveys and Questionnaires ,Immunology and Allergy ,Middle Aged ,Mobile Applications ,3. Good health ,Medication possession ratio ,rhiniti ,1107 Immunology ,Ciências Médicas::Medicina Básica ,Female ,TRIAL ,Life Sciences & Biomedicine ,Adult ,medicine.medical_specialty ,Immunology ,K-ANONYMITY ,VALIDATION ,1117 Public Health and Health Services ,Medication Adherence ,03 medical and health sciences ,Internal medicine ,Health Sciences ,medicine ,Humans ,Clinical significance ,Mobile technology ,[INFO]Computer Science [cs] ,Asthma ,Aged ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,Science & Technology ,Relative efficacy ,business.industry ,PERSISTENCE ,medicine.disease ,Rhinitis, Allergic ,Cell Phone Use ,Patient Outcome Assessment ,030104 developmental biology ,Cross-Sectional Studies ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,MASK group ,ASTHMA ,Observational study ,business - Abstract
Pereira, Ana Margarida/0000-0002-5468-0932; Briedis, Vitalis/0000-0002-5106-6638; Johnston, Sebastian Lennox/0000-0003-3009-9200; Orlando, Valentina/0000-0002-8209-8878; Sova, Milan/0000-0002-8542-7841; Chung, Kian Fan/0000-0001-7101-1426; Ciprandi, Giorgio/0000-0001-7016-8421; Yusuf, M Osman/0000-0002-8067-1204; stelmach, rafael/0000-0002-5132-1934; Sunyer, Jordi/0000-0002-2602-4110; Martins, Pedro/0000-0002-4129-133X; Demoly, Pascal/0000-0001-7827-7964; Fonseca, Joao Almeida/0000-0002-0887-8796; Anto, J M/0000-0002-4736-8529; IACCARINO, Guido/0000-0002-8997-835X; Custovic, Adnan/0000-0001-5218-7071; Lourenco, Olga/0000-0002-8401-5976; Pugin, Benoit/0000-0001-7132-9477; Chavannes, Niels/0000-0002-8607-9199; Rodo, Xavier/0000-0003-4843-6180; Nadif, Rachel/0000-0003-4938-9339; Plavec, Davor/0000-0003-2020-8119; Vicheva, Dilyana/0000-0002-6805-3825; Iaccarino, Guido/0000-0002-8997-835X; Annesi-Maesano, Isabella/0000-0002-6340-9300; N.G., Papadopoulos/0000-0002-4448-3468; J, Garcia-Aymerich/0000-0002-7097-4586; Humbert, Marc/0000-0003-0703-2892; Barbara, C./0000-0003-0915-4105; Gemicioglu, Bilun/0000-0001-5953-4881; Caimmi, Davide/0000-0003-4481-6194; Namazova-Baranova, Leyla/0000-0002-2209-7531; Basagana, Xavier/0000-0002-8457-1489; Midao, Luis/0000-0003-1981-2554; Sheikh, Aziz/0000-0001-7022-3056; O'Hehir, Robyn/0000-0002-3489-7595; Cardona, Victoria/0000-0003-2197-9767; Mota-Pinto, Anabela/0000-0002-0820-9568; Cecchi, Lorenzo/0000-0002-0658-2449; Bindslev-Jensen, Carsten/0000-0002-8940-038X; Costa, Elisio/0000-0003-1158-1480; Kuna, Piotr/0000-0003-2401-0070; Malva, Joao/0000-0002-5438-4447; Zuberbier, Torsten/0000-0002-1466-8875; Toppila-Salmi, Sanna/0000-0003-0890-6686; Nogueira-Silva, Luis/0000-0002-5519-707X; Ivancevich, Juan Carlos/0000-0001-8713-6258 WOS:000463761700007 PubMed ID: 30597673 Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC = 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR
- Published
- 2019
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