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9 results on '"Bossel, Noa"'

3. Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation

Author

Canu, Valeria, primary, Donzelli, Sara, additional, Sacconi, Andrea, additional, Lo Sardo, Federica, additional, Pulito, Claudio, additional, Bossel, Noa, additional, Di Benedetto, Anna, additional, Muti, Paola, additional, Botti, Claudio, additional, Domany, Eytan, additional, Bicciato, Silvio, additional, Strano, Sabrina, additional, Yarden, Yosef, additional, and Blandino, Giovanni, additional

Published
2020
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4. Proteomic patterns associated with response to breast cancer neoadjuvant treatment

Author

Shenoy, Anjana, primary, Belugali Nataraj, Nishanth, additional, Perry, Gili, additional, Loayza Puch, Fabricio, additional, Nagel, Remco, additional, Marin, Irina, additional, Balint, Nora, additional, Bossel, Noa, additional, Pavlovsky, Anya, additional, Barshack, Iris, additional, Kaufman, Bella, additional, Agami, Reuven, additional, Yarden, Yosef, additional, Dadiani, Maya, additional, and Geiger, Tamar, additional

Published
2020
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5. Controls for Phylogeny and Robust Analysis in Pareto Task Inference.

Author

Adler, Miri, Tendler, Avichai, Hausser, Jean, Korem, Yael, Szekely, Pablo, Bossel, Noa, Hart, Yuval, Karin, Omer, Mayo, Avi, and Alon, Uri

Subjects
PHYLOGENY, SYSTEMS biology, ECOLOGY, BIOLOGICAL evolution, CANCER genes
Abstract

Understanding the tradeoffs faced by organisms is a major goal of evolutionary biology. One of the main approaches for identifying these tradeoffs is Pareto task inference (ParTI). Two recent papers claim that results obtained in ParTI studies are spurious due to phylogenetic dependence (Mikami T, Iwasaki W. 2021. The flipping t-ratio test: phylogenetically informed assessment of the Pareto theory for phenotypic evolution. Methods Ecol Evol. 12(4):696–706) or hypothetical p-hacking and population-structure concerns (Sun M, Zhang J. 2021. Rampant false detection of adaptive phenotypic optimization by ParTI-based Pareto front inference. Mol Biol Evol. 38(4):1653–1664). Here, we show that these claims are baseless. We present a new method to control for phylogenetic dependence, called SibSwap, and show that published ParTI inference is robust to phylogenetic dependence. We show how researchers avoided p-hacking by testing for the robustness of preprocessing choices. We also provide new methods to control for population structure and detail the experimental tests of ParTI in systems ranging from ammonites to cancer gene expression. The methods presented here may help to improve future ParTI studies. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Abstract 4011: Tumor evolution inferred by patterns of miRNA expression through the course of disease, therapy and recurrence in breast cancer

Author

Dadiani, Maya, primary, Bossel, Noa, additional, Paluch-Shimon, Shani, additional, Peri, Gili, additional, Pavlovski, Anya, additional, Kahana-Edwin, Smadar, additional, Balint, Nora, additional, Yosepovich, Adi, additional, Zundelevich, Adi, additional, Gal-Yam, Einav, additional, Berger, Raanan, additional, Barshack, Iris, additional, Domany, Eytan, additional, and Kaufman, Bella, additional

Published
2015
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8. EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

Author

Avraham, Roi, primary, Sas-Chen, Aldema, additional, Manor, Ohad, additional, Steinfeld, Israel, additional, Shalgi, Reut, additional, Tarcic, Gabi, additional, Bossel, Noa, additional, Zeisel, Amit, additional, Amit, Ido, additional, Zwang, Yaara, additional, Enerly, Espen, additional, Russnes, Hege G., additional, Biagioni, Francesca, additional, Mottolese, Marcella, additional, Strano, Sabrina, additional, Blandino, Giovanni, additional, Børresen-Dale, Anne-Lise, additional, Pilpel, Yitzhak, additional, Yakhini, Zohar, additional, Segal, Eran, additional, and Yarden, Yosef, additional

Published
2010
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