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8. Osteoinduction and osteoimmunology: Emerging concepts.

Author

Miron, Richard J., Bohner, Marc, Zhang, Yufeng, and Bosshardt, Dieter D.

Subjects
OSTEOINDUCTION, BONE regeneration, SURFACE charges, IMMUNE recognition, GROWTH factors, ARTIFICIAL implants, MONOMOLECULAR films
Abstract

The recognition and importance of immune cells during bone regeneration, including around bone biomaterials, has led to the development of an entire field termed "osteoimmunology," which focuses on the connection and interplay between the skeletal system and immune cells. Most studies have focused on the "osteogenic" capacity of various types of bone biomaterials, and much less focus has been placed on immune cells despite being the first cell type in contact with implantable devices. Thus, the amount of literature generated to date on this topic makes it challenging to extract needed information. This review article serves as a guide highlighting advancements made in the field of osteoimmunology emphasizing the role of the osteoimmunomodulatory properties of biomaterials and their impact on osteoinduction. First, the various immune cell types involved in bone biomaterial integration are discussed, including the prominent role of osteal macrophages (OsteoMacs) during bone regeneration. Thereafter, key biomaterial properties, including topography, wettability, surface charge, and adsorption of cytokines, growth factors, ions, and other bioactive molecules, are discussed in terms of their impact on immune responses. These findings highlight and recognize the importance of the immune system and osteoimmunology, leading to a shift in the traditional models used to understand and evaluate biomaterials for bone regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Sequential osseointegration of a novel implant system based on <scp>3D</scp> printing in comparison with conventional titanium implants

Author

Lang, Niklaus P, Imber, Jean-Claude, Lang, Kiri N, Schmid, Bruno, Muñoz, Fernando, Bosshardt, Dieter D, and Saulacic, Nikola

Subjects
610 Medicine & health, Oral Surgery, 610 Medizin und Gesundheit
Abstract

OBJECTIVES To evaluate the sequential osseointegration of a novel titanium implant system based on a 3D printing technology in comparison with conventional titanium implants. MATERIAL AND METHODS Two novel titanium implants based on 3D printing were tested in the mandible of eight Beagle dogs. As a control, two different commercially available titanium implants were used. The implants were staged to accommodate healing periods of 2 and 6 weeks. The primary outcome variable was bone-to-implant contact (BIC) in non-decalcified tissue sections and micro-CT analysis. RESULTS Histomorphometrically, the proportions of tissues adjacent to the implant surfaces were similar for all implants, whereas the BIC percentage of new mineralized bone was greater for the control implants after both 2 and 6 weeks (p

Published
2023

18. Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin

Author

Chackartchi, Tali, Bosshardt, Dieter D, Imber, Jean-Claude, Stähli, Alexandra, Sacks, Hagit, Nagy, Katalin, and Sculean, Anton

Subjects
610 Medicine & health
Abstract

OBJECTIVES To histologically evaluate the effects of a novel human recombinant amelogenin (rAmelX) on periodontal wound healing / regeneration in recession-type defects. MATERIALS AND METHODS A total of 17 gingival recession-type defects were surgically created in the maxilla of three minipigs. The defects were randomly treated with a coronally advanced flap (CAF) and either rAmelX (test), or a CAF and placebo (control). At three months following reconstructive surgery, the animals were euthanized, and the healing outcomes histologically evaluated. RESULTS The test group yielded statistically significantly (p = 0.047) greater formation of cementum with inserting collagen fibers compared with the control group (i.e., 4.38 mm ± 0.36 mm vs. 3.48 mm ± 1.13 mm). Bone formation measured 2.15 mm ± 0.8 mm in the test group and 2.24 mm ± 1.23 mm in the control group, respectively, without a statistically significant difference (p = 0.94). CONCLUSIONS The present data have provided for the first-time evidence for the potential of rAmelX to promote regeneration of periodontal ligament and root cementum in recession-type defects, thus warranting further preclinical and clinical testing. CLINICAL RELEVANCE The present results set the basis for the potential clinical application of rAmelX in reconstructive periodontal surgery.

Published
2023
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27. Evidence of re-osseointegration after electrolytic cleaning and regenerative therapy of peri-implantitis in humans: a case report with four implants

Author

Bosshardt, Dieter D, Brodbeck, Urs R, Rathe, Florian, Stumpf, Thomas, Imber, Jean-Claude, Weigl, Paul, and Schlee, Markus

Subjects
Dental Implants, Bone Regeneration, Osseointegration, Humans, 610 Medicine & health, Peri-Implantitis, General Dentistry
Abstract

Objective To evaluate re-osseointegration after electrolytic cleaning and regenerative therapy of dental implants with peri-implantitis in humans. Material and methods Four dental implants that developed peri-implantitis underwent electrolytic cleaning followed by regenerative therapy with guided bone regeneration. All four implants developed recurrent peri-implantitis and were therefore explanted 6 to 13 months later. Radiographic bone level, probing depth, and bleeding on probing were determined at the time of surgery, 6 months later, and before implant retrieval. The peri-implant tissues were histologically and histomorphometrically analyzed. Results All four implants demonstrated radiographic and histological bone gain, reduced probing depth, and bleeding on probing. Radiographic bone gain was 5.8 mm mesially and 4.8 mm distally for implant #1, 3.3 mm and 2.3 mm for implant #2, 3.1 mm and 0.5 mm for implant #3, and 3.5 mm and 2.8 mm for implant #4. The histometric mean and maximum vertical bone gain for implant #1 to #4 was 1.65 mm and 2.54 mm, 3.04 mm and 3.47 mm, 0.43 mm and 1.27 mm, and 4.16 mm and 5.22 mm, respectively. The percentage of re-osseointegration for implant #1 to #4 was 21.0%, 36.9%, 5.7%, and 39.0%, respectively. In one implant, the newly formed bone was deposited directly onto calculus on the implant surface. Conclusions We found that (1) re-osseointegration is possible on a formerly contaminated implant surface and (2) the electrolytic cleaning process seems to be effective enough at sites with calculus residues. Clinical relevance Since re-osseointegration can be achieved by electrolytic cleaning, this decontamination technique may be considered as a future treatment concept.

Published
2022

35. 20-Year Follow-up in Maxillary Sinus Floor Elevation Using Bovine-Derived Bone Mineral: A Case Report with Histologic and Histomorphometric Evaluation.

Author

Valentini, Pascal and Bosshardt, Dieter D.

Subjects
MAXILLARY sinus surgery, MAXILLARY sinus, BIOMEDICAL materials, BONE grafting, HISTOLOGICAL techniques, POSTOPERATIVE period, ANATOMY
Abstract

Bovine-derived bone mineral demonstrated good osteoconductive properties as grating material for maxillary sinus floor elevation, but the long-term behavior of this material has not been reported. The purpose of this report was to analyze and compare histomorphometric measurements of new bone, bone graft, and medullar spaces 6 months, 12 months, and 20 years after grafting. In the grafted area, the amount of mineralized bone was 16.96% at 6 months, 22.53% at 12 months, and 22.05% at 20 years, respectively. The amount of bovine-derived bone mineral ranged from 35.87% to 4.85% in the same period. The volume of the newly formed mineralized bone does not increase over time, conversely to nonmineralized bone. [ABSTRACT FROM AUTHOR]

Published
2018
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45. List of Contributors

Author

Ahadian, Samad, primary, Akiyaman, Kentaro, additional, Alansari, Sarah, additional, Alikhani, Mani, additional, Alikhani, Mona, additional, Arthur, Agnieszka, additional, Arulkumar, Shylaja, additional, Baiguera, Silvia, additional, Bianco, Alessandra, additional, Bissada, Nabil F., additional, Bleicher, Françoise, additional, Bliley, Jacqueline M., additional, Bosshardt, Dieter D., additional, Botero, Tatiana M., additional, Braga, Raquel, additional, Briggs, Kristen K., additional, Brooks, Patricia J., additional, Cannon, Kevin, additional, Carrouel, Florence, additional, Chavez, Miquella G., additional, Cheng, Ming-Te, additional, Christ, George J., additional, Cook, Colin A., additional, Cooper, Paul R., additional, Cox, Timothy C., additional, Cunningham, Michael L., additional, Dashe, Jesse, additional, Davidovitch, Ze’ev, additional, Davies, Lindsay C., additional, Del Gaudio, Costantino, additional, Diekwisch, Thomas G.H., additional, Diogenes, Anibal, additional, Duncan, Randall L., additional, Edwards, Paul C., additional, El-Bialy, Tarek, additional, Enlow, Donald H., additional, Farach-Carson, Mary C., additional, Farges, Jean-Christophe, additional, Feinberg, Stephen E., additional, Felfy, Hady, additional, Freeman, Phillip N., additional, Freilich, Martin, additional, Fujie, Toshinori, additional, Gao, Changyou, additional, Giannobile, William V., additional, Gong, Siew-Ging, additional, Grayson, Warren L., additional, Greene, Robert M., additional, Gronthos, Stan, additional, Gruber, Reinhard, additional, Häkkinen, Lari, additional, Hanna, Craig, additional, Hargreaves, Kenneth M., additional, Satoshi, Emilio Hara, additional, Harrington, Daniel A., additional, Hashmi, Basma, additional, Heino, Jyrki, additional, Hing, Anne V., additional, Holmes, Christina, additional, Honda, Masaki J., additional, Horst, Jeremy A., additional, Hu, Michael S., additional, Hughes, Francis J., additional, Hung, Ben P., additional, Huri, Pinar Yilgor, additional, Ingber, Donald E., additional, Isokawa, Keitaro, additional, Izumi, Kenji, additional, James, Eric N., additional, Jia, Xinqiao, additional, Jin, Yan, additional, Emily Joo, E., additional, Juuri, Emma, additional, Kagami, Hideaki, additional, Kaji, Hirokazu, additional, Kang, Mo K., additional, Kashi, A., additional, Kato, Hiroko, additional, Kaur, Jasvir, additional, Keller, Letitia V., additional, Kemp, Paul D., additional, Khademhosseini, Ali, additional, Khoo, Edmund, additional, Kim, Hae-Won, additional, King, William J., additional, Kirschner, Richard E., additional, Klein, Ophir D., additional, Knowles, Jonathan C., additional, Koivisto, Leeni, additional, Kökten, Tunay, additional, Krebsbach, Paul H., additional, Kuboki, Takuo, additional, Kuchler-Bopp, Sabine, additional, Kucska, Simone, additional, Kuhn, Liisa, additional, Larjava, Hannu, additional, Lee, Eun-Jung, additional, Lee, Joo-Hee, additional, Lee, Oscar K., additional, Lee, Yoo Bin, additional, Lesot, Hervé, additional, Lewis, Mark P., additional, Li, Bei, additional, Li, Luyan, additional, Lim, Jung Yul, additional, Liu, Xing, additional, Liu, Xiaohua, additional, Lo, David D., additional, Longaker, Michael T., additional, Peter Lorenz, H., additional, Lott, David G., additional, Lungová, Vlasta, additional, Ma, Lie, additional, Macchiarini, Paolo, additional, Mammoto, Tadanori, additional, Marei, Mona K., additional, Marolt, Darja, additional, Marra, Kacey G., additional, Martin, Neil R.W., additional, Matalová, Eva, additional, Matsue, Tomokazu, additional, Mehrazarin, Shebli, additional, Mina, Mina, additional, Modo, Michel, additional, Mokry, Jaroslav, additional, Morsczeck, Christian, additional, Moussa, Rania M., additional, Murphy, Neal C., additional, Mushegyan, Vagan, additional, Nagy, Naglaa B., additional, Nair, Lakshmi S., additional, Nayar, Harry, additional, Nör, Jacques E., additional, Obregón, Raquel, additional, Oh, Tae-Ju, additional, Oka, Kyoko, additional, Ostrovidov, Serge, additional, Park, No-Hee, additional, Passineau, Michael J., additional, Passipieri, Juliana A., additional, Pisal, Rishikaysh, additional, Player, Darren, additional, Pradhan-Bhatt, Swati, additional, Parthiban, Selvakumar Prakash, additional, Prochazka, Jan, additional, Prochazkova, Michaela, additional, Qu, Tiejun, additional, Ramalingam, Murugan, additional, Ramón-Azcón, Javier, additional, Rana, Deepti, additional, Ray, Herbert L., additional, Reed, David A., additional, Reinhardt, Dieter P., additional, Richard, Béatrice, additional, Riehl, Brandon D., additional, Rios, Hector F., additional, Peter Rubin, J., additional, Saad, Manal M., additional, Sachar, Ashneet, additional, Sah, Robert L., additional, Saha, Subrata, additional, Saito, Yoko, additional, Sampathkumar, Kaarunya, additional, Sangsuwon, Chinapa, additional, Seo, Byoung Moo, additional, Sharpe, Paul, additional, Shi, Songtao, additional, Shih, Yu-Ru V., additional, Shiku, Hitoshi, additional, Shin, Seung Yun, additional, Sjöqvist, Sebastian, additional, Sloan, Alastair J., additional, Smith, Anthony (Tony) J., additional, Song, In Seok, additional, Stephens, Neil, additional, Stephens, Phil, additional, Svoboda, Kathy K.H., additional, Tabrizian, Maryam, additional, Teixeira, Cristina, additional, Teixeira, Fabricio B., additional, Temple, Joshua P., additional, Thesleff, Irma, additional, Thivichon-Prince, Béatrice, additional, Toriumi, Taku, additional, Treasure, Trevor E., additional, Um, Soyoun, additional, Vishwakarma, Ajaykumar, additional, Wang, Chunfen, additional, Watson, Deborah, additional, Watson, Jeffrey B., additional, Wen, Bo, additional, Witt, Robert L., additional, Wong, Mark E., additional, Yamada, Kenneth M., additional, Yassin, Hala H., additional, Zakheim, Daniel, additional, Zhang, Bing, additional, and Zimmermann, Andrew S., additional

Published
2015
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47. Cemental Tear (Zementabscherung)

Author

Michelotti, Gioia, Sahrmann, Philipp, Tauböck, Tobias T, Bosshardt, Dieter D, and University of Zurich

Subjects
3501 Dentistry (miscellaneous), 10066 Clinic of Conservative and Preventive Dentistry, 610 Medicine & health
Published
2021

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