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2. Late morbidity and mortality after autologous blood or marrow transplantation for lymphoma in children, adolescents and young adults—a BMTSS report

Author

Holmqvist, Anna Sällfors, Meng, Qingrui, Dai, Chen, Hageman, Lindsey, Landier, Wendy, Wu, Jessica, Francisco, Liton F., Ross, Elizabeth Schlichting, Balas, Nora, Bosworth, Alysia, Te, Hok Sreng, Bhatia, Ravi, Rosenthal, Joseph, Wong, F. Lennie, Weisdorf, Daniel, Armenian, Saro H., and Bhatia, Smita

Published
2024
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3. Clonal Hematopoiesis and Risk of Heart Failure After Autologous Hematopoietic Cell Transplantation for Lymphoma

Author

Rhee, June-Wha, Pillai, Raju, Chen, Sitong, Bosworth, Alysia, Oganesyan, Artem, Atencio, Liezl, Freeman, Kendall, Estrada, Caitlyn, Guzman, Tati, Lukas, Kara, Peng, Kelly, Sigala, Brianna, Lukuridze, Aleksi, Lindenfeld, Lanie, Jamal, Faizi, Natarajan, Pradeep, Bhatia, Smita, Herrera, Alex F., Mei, Matthew G., Nakamura, Ryotaro, Wong, F. Lennie, Forman, Stephen J., and Armenian, Saro H.

Published
2025
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10. Self‐rated health is an independent predictor of subsequent late mortality after blood or marrow transplantation: A Blood or Marrow Transplant Survivor Study report.

Author

Balas, Nora, Richman, Joshua, Landier, Wendy, Shrestha, Sadeep, Bruxvoort, Katia J., Hageman, Lindsey, Meng, Qingrui, Ross, Elizabeth, Bosworth, Alysia, Te, Hok Sreng, Wong, F. Lennie, Bhatia, Ravi, Forman, Stephen J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita

Subjects
MEDICAL record databases, SOCIODEMOGRAPHIC factors, BONE marrow, PSYCHOLOGICAL distress, VITAL records (Births, deaths, etc.), HEALTH behavior
Abstract

Background: The prevalence of suboptimal self‐rated health (SRH) and its association with subsequent all‐cause and cause‐specific mortality after blood or marrow transplantation (BMT) were examined. Methods: Study participants were drawn from the multicenter Blood or Marrow Transplant Survivor Study, and included patients who were transplanted between 1974 and 2014 and had survived ≥2 years after BMT. Participants (aged ≥18 years) completed a survey at a median of 9 years from BMT, and were followed for a median of 5.6 years after survey completion. Survivors provided information on sociodemographic factors, chronic health conditions, health behaviors, and SRH (a single‐item measure rated as excellent, very good, good, fair, or poor; excellent, very good, and good SRH were classified as good SRH, and fair and poor were classified as suboptimal SRH). The National Death Index Plus and Accurint databases and medical records provided vital status through December 2021. Results: Of 3739 participants, 784 died after survey completion (21%). Overall, 879 BMT survivors (23.5%) reported suboptimal SRH. Pain, low socioeconomic status, psychological distress, lack of exercise, severe/life‐threatening chronic health conditions, post‐BMT relapse, obesity, smoking, and male sex were associated with suboptimal SRH. BMT survivors who reported suboptimal SRH had a 1.9‐fold increased risk of all‐cause mortality (95% confidence interval [CI], 1.6–2.3), 1.8‐fold increased risk of recurrence‐related mortality (95% CI, 1.4–2.5), and 1.9‐fold increased risk of non–recurrence‐related mortality (95% CI, 1.4–2.4) compared to those who reported good SRH. Conclusions: This single‐item measure could help identify vulnerable subpopulations who could benefit from interventions to mitigate the risk for subsequent mortality. A single‐item question on self‐rated health can serve as a predictor of subsequent mortality independent of all other demographic and clinical prognosticators of late mortality. This finding suggests that self‐rated health can possibly be incorporated into the workflow of clinical follow‐up of blood or marrow transplantation survivors to provide risk‐stratified care. [ABSTRACT FROM AUTHOR]

Published
2025
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12. Sex-Based Differences in Risk of Therapy-Related Myeloid Neoplasms.

Author

Richard, Melissa A., Yan, Chengcheng, Chen, Yanjun, Gibson, Christopher J., Kalra, Rashi, Bosworth, Alysia, Crossman, David K., Singh, Purnima, Hageman, Lindsey, He, Jianbo, Armenian, Saro H., Vose, Julie, Weisdorf, Daniel J., Ebert, Benjamin L, Yasui, Yutaka, Cheng, Changde, Forman, Stephen J., Bhatia, Smita, and Bhatia, Ravi

Published
2024
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13. Clonal Hematopoiesis is Associated With Severe Cytokine Release Syndrome in Patients Treated With Chimeric Antigen Receptor T-Cell (CART) Therapy

Author

Goldsmith, Scott R., Shouse, Geoffrey, Wong, F. Lennie, Bosworth, Alysia, Iukuridze, Aleksi, Chen, Sitong, Rhee, June-Wha, Mei, Matthew, Htut, Myo, Janakiram, Murali, Forman, Stephen J., Pillai, Raju, Budde, L Elizabeth, and Armenian, Saro H.

Abstract

•Clonal hematopoiesis (CH) is frequent in patients with non-Hodgkin lymphoma and multiple myeloma.•Pre-CAR T CH was associated with a higher incidence of severe cytokine release syndrome (CRS).•Clonal hematopoiesis could serve as a predictive biomarker for prevention strategies for CRS.

Published
2024
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14. Coronary artery calcium and cardiovascular outcomes in patients with lymphoma undergoing autologous hematopoietic cell transplantation

Author

Wu, Stephanie, primary, Rhee, June‐Wha, additional, Iukuridze, Aleksi, additional, Bosworth, Alysia, additional, Chen, Sitong, additional, Atencio, Liezl, additional, Manubolu, Venkat, additional, Bhandari, Rusha, additional, Jamal, Faizi, additional, Mei, Matthew, additional, Herrera, Alex, additional, Rodriguez, Fatima, additional, Forman, Stephen, additional, Nakamura, Ryotaro, additional, Wong, F. Lennie, additional, Budoff, Matthew, additional, and Armenian, Saro H., additional

Published
2024
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15. Body composition and late‐occurring chronic health conditions after autologous stem cell transplantation for lymphoma.

Author

Giri, Smith, Harmon, Christian, Landier, Wendy, Chen, Yanjun, Wu, Jessica, Hageman, Lindsey, Balas, Nora, Francisco, Liton, Bosworth, Alysia, Weisdorf, Daniel J., Forman, Stephen J., Armenian, Saro H., Williams, Grant R., and Bhatia, Smita

Subjects
BODY composition, STEM cell transplantation, CHRONIC diseases, ADIPOSE tissues, MUSCLE mass, ADIPOSE tissue diseases, VISCERAL pain
Abstract

Background: Autologous peripheral blood stem cell transplantation (aPBSCT) is the standard of care for adults with relapsed lymphoma, yet recipients remain at risk of developing chronic health conditions (CHCs). It was hypothesized that body composition measurements of skeletal muscle and fat are associated with late‐onset CHCs and nonrelapse mortality after aPBSCT. Methods: Leveraging the Blood or Marrow Transplant Survivor Study, we examined association between pre‐aPBSCT body composition and new‐onset grade 3–5 CHCs among 187 adults with lymphoma treated with aPBSCT (2011–2014) surviving ≥2 years after aPBSCT. Using computed tomography scans at the L3 level, skeletal muscle mass (skeletal muscle area and skeletal muscle density [SMD]) and body fat (subcutaneous adipose tissue and visceral adipose tissue) were measured and quantified as sex‐specific z‐scores. Competing risk models were built to study the impact of body composition on incident grade 3 through 5 CHCs and nonrelapse mortality (NRM) adjusting for confounders. Results: The study cohort had a median age at aPBSCT of 57 years with 63% males, 77% non‐Hispanic Whites and 81% with non‐Hodgkin lymphoma. The 5‐year cumulative incidence of grade 3 through 5 CHCs was 47% (95% Confidence Interval, CI, 38%–56%). Each SD increase in SMD was associated with 30% reduced risk of grade 3 through 5 CHCs (95% CI, 0.50–0.96). The 10‐year cumulative incidence of NRM was 16% (95% CI, 10–22). No body composition measure was associated with NRM. Conclusions: The association between SMD and grade 3 through 5 CHCs following aPBSCT could inform development of prognostic models to identify adults with lymphoma at greatest risk of morbidity following aPBSCT. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant

Author

Rhee, June-Wha, primary, Pillai, Raju, additional, He, Tianhui, additional, Bosworth, Alysia, additional, Chen, Sitong, additional, Atencio, Liezl, additional, Oganesyan, Artem, additional, Peng, Kelly, additional, Guzman, Tati, additional, Lukas, Kara, additional, Sigala, Brianna, additional, Iukuridze, Aleksi, additional, Lindenfeld, Lanie, additional, Jamal, Faizi, additional, Natarajan, Pradeep, additional, Goldsmith, Scott, additional, Krishnan, Amrita, additional, Rosenzweig, Michael, additional, Wong, F. Lennie, additional, Forman, Stephen J., additional, and Armenian, Saro, additional

Published
2023
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19. Health care utilization by long‐term survivors of blood or marrow transplantation—A Bone Marrow Transplant Survivor Study report.

Author

Oliver, Marian M., Meng, Qingrui, Hageman, Lindsey, Landier, Wendy, Balas, Nora, Ross, Elizabeth, Francisco, Liton, Bosworth, Alysia, Te, Hok Sreng, Wong, F. Lennie, Bhatia, Ravi, Forman, Stephen J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita

Subjects
MEDICAL care use, LONG-term health care, BONE marrow, PHYSICIAN services utilization, UTILIZATION review (Medical care), MEDICAL records
Abstract

Background: Blood or marrow transplantation (BMT) survivors carry a high burden of morbidity, yet health care utilization by this vulnerable population remains understudied. Patterns and predictors of various domains of health care utilization in long‐term BMT survivors were evaluated. Methods: Study participants were drawn from the Bone Marrow Transplant Survivor Study (BMTSS). Patients transplanted between 1974 and 2014 at one of three transplant centers who had survived ≥2 years after BMT and were aged ≥18 years at the time of the study were included. A BMTSS survey served as the source of data for health care utilization, sociodemographics, and chronic health conditions. Domains of health care utilization in the 2 years preceding study participation included routine checkups, BMT‐related visits, transplant/cancer center visits, emergency room (ER) visits, hospitalizations, and high health care utilization (≥7 physician visits during the 2 years before the study). Clinical characteristics and therapeutic exposures were abstracted from medical records. Results: In this cohort of 3342 BMT survivors (52% allogeneic), the prevalence of health care utilization declined over time since BMT for both allogeneic and autologous BMT survivors, such that among those who had survived ≥20 years, only 49%–53% had undergone routine checkups, 37%–38% reported BMT‐related visits, and 28%–29% reported transplant/cancer center visits. The presence of severe/life‐threatening conditions and chronic graft‐vs‐host disease increased the odds of health care utilization across all domains. Lower education, lack of insurance, and Hispanic ethnicity were associated with a lower prevalence of routine checkups and/or transplant/cancer center visits. Lower income increased the odds of ER visits but reduced the odds of hospitalizations or high health care utilization. Conclusions: This study identified vulnerable populations of long‐term BMT survivors who would benefit from specialized risk‐based anticipatory care to reduce high health care utilization, ER visits, and hospitalizations. Health care utilization (including routine medical checkups) declines with increasing time since blood or marrow transplantation, except among survivors with severe/life‐threatening chronic health conditions as well as those with chronic graft‐vs‐host disease. Lower education and lack of insurance are associated with lower health care utilization. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant.

Author

Rhee, June-Wha, Pillai, Raju, He, Tianhui, Bosworth, Alysia, Chen, Sitong, Atencio, Liezl, Oganesyan, Artem, Peng, Kelly, Guzman, Tati, Lukas, Kara, Sigala, Brianna, Iukuridze, Aleksi, Lindenfeld, Lanie, Jamal, Faizi, Natarajan, Pradeep, Goldsmith, Scott, Krishnan, Amrita, Rosenzweig, Michael, Wong, F. Lennie, and Forman, Stephen J.

Published
2024
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21. Association Between Pretreatment Skeletal Muscle and Outcomes After CAR T-Cell Therapy

Author

Lee, Kyuwan, primary, Iukuridze, Aleksi, additional, He, Tianhui, additional, Bosworth, Alysia, additional, Lindenfeld, Lanie, additional, Teh, Jennifer Berano, additional, Echevarria, Meagan, additional, Albanese, Sophia, additional, Atencio, Liezl, additional, Bhandari, Rusha, additional, Wong, F. Lennie, additional, Artz, Andrew S., additional, Siddiqi, Tanya, additional, Nikolaenko, Liana, additional, Zain, Jasmine, additional, Mei, Matthew, additional, Shouse, Geoffrey, additional, Popplewell, Leslie L., additional, Herrera, Alex F., additional, Budde, L. Elizabeth, additional, Forman, Stephen J., additional, and Armenian, Saro H., additional

Published
2023
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22. Financial Burden in Blood or Marrow Transplantation Survivors During the COVID-19 Pandemic: A BMTSS Report

Author

Bhatia, Smita, primary, Dai, Chen, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Siler, Arianna, additional, Funk, Erin, additional, Hicks, Jessica, additional, Lim, Shawn, additional, Balas, Nora, additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Francisco, Liton, additional, Bhatia, Ravi, additional, Forman, Stephen J., additional, Wong, F. Lennie, additional, Arora, Mukta, additional, Armenian, Saro H., additional, Weisdorf, Daniel J., additional, and Landier, Wendy, additional

Published
2023
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23. Malignant Neoplasms of the Gastrointestinal Tract After Blood or Marrow Transplant

Author

McDonald, Andrew, primary, Dai, Chen, additional, Meng, Qingrui, additional, Hageman, Lindsey, additional, Richman, Joshua, additional, Wu, Jessica, additional, Francisco, Liton, additional, Ross, Elizabeth, additional, Balas, Nora, additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Wong, F. Lennie, additional, Landier, Wendy, additional, Salzman, Donna, additional, Bhatia, Ravi, additional, Weisdorf, Daniel J., additional, Forman, Stephen J., additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2023
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24. Severe, life‐threatening, and fatal chronic health conditions after allogeneic blood or marrow transplantation in childhood

Author

Holmqvist, Anna Sällfors, primary, Chen, Yanjun, additional, Hageman, Lindsey, additional, Landier, Wendy, additional, Wu, Jessica, additional, Francisco, Liton F., additional, Ross, Elizabeth Schlichting, additional, Balas, Nora A., additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Goldman, Frederick D., additional, Rosenthal, Joseph, additional, Wong, F. Lennie, additional, Weisdorf, Daniel J., additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2022
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25. Risk of Subsequent Malignant Neoplasms Following Hematopoietic Stem Cell Transplantation with Total Body Irradiation or Total Marrow Irradiation: Insights from Early Follow-Up

Author

Ladbury, Colton, primary, Armenian, Saro, additional, Bosworth, Alysia, additional, He, Tianhui, additional, Wong, F. Lennie, additional, Dandapani, Savita, additional, Han, Chunhui, additional, Liu, An, additional, Al Malki, Monzr, additional, Rosenthal, Joseph, additional, Stein, Anthony, additional, and Wong, Jeffrey, additional

Published
2022
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26. Potentially inappropriate medications in geriatric blood or marrow transplantation (BMT) survivors: A BMT Survivor Study report

Author

Sanchez‐Luege, Sebastian, primary, Landier, Wendy, additional, Dai, Chen, additional, Hageman, Lindsey, additional, Ross, Elizabeth S., additional, Balas, Nora A., additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Wu, Jessica, additional, Francisco, Liton, additional, Wong, F. Lennie, additional, Forman, Stephen J., additional, Armenian, Saro H., additional, Weisdorf, Daniel J., additional, and Bhatia, Smita, additional

Published
2022
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27. Late Morbidity and Mortality after Autologous Blood or Marrow Transplantation (BMT) for Lymphoma in Children, Adolescents and Young Adults - a Report from the BMT Survivor Study (BMTSS)

Author

Holmqvist, Anna Sallfors, primary, Meng, Qingrui, additional, Dai, Chen, additional, Hageman, Lindsey, additional, Landier, Wendy, additional, Wu, Jessica, additional, Francisco, Liton F., additional, Schlichting, Elizabeth, additional, Balas, Nora, additional, Bosworth, Alysia, additional, Sreng Te, Hok, additional, Bhatia, Ravi, additional, Rosenthal, Joseph, additional, Wong, Lennie, additional, Weisdorf, Daniel J., additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2022
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28. Individual Prediction of Cardiovascular Events in Blood or Marrow Transplant Survivors - a BMT Survivor Study Report

Author

Gangaraju, Radhika, primary, Chen, Yanjun, additional, Hageman, Lindsey, additional, Landier, Wendy, additional, Balas, Nora, additional, Schlichting, Elizabeth, additional, Francisco, Liton F., additional, Bosworth, Alysia, additional, Sreng Te, Hok, additional, Wong, Lennie, additional, Weisdorf, Daniel J., additional, Bhatia, Ravi, additional, Forman, Stephen J, additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2022
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29. Specific Clonal Mutations Are Predictive of Therapy-Related Myeloid Neoplasms (tMN) after Autologous Peripheral Blood Stem Cell Transplantation (aPBSCT) for Lymphoma

Author

Bhatia, Smita, primary, Yan, Chengcheng, additional, Richard, Melissa A, additional, He, Jianbo, additional, Bosworth, Alysia, additional, Crossman, David, additional, Singh, Purnima, additional, Hageman, Lindsey, additional, Armenian, Saro H., additional, Vose, Julie M., additional, Weisdorf, Daniel J., additional, Yasui, Yutaka, additional, Ebert, Benjamin L., additional, Gibson, Christopher J., additional, Forman, Stephen J, additional, and Bhatia, Ravi, additional

Published
2022
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30. Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study

Author

Armenian, Saro H., primary, Chen, Yanjun, additional, Hageman, Lindsay, additional, Wu, Jessica, additional, Landier, Wendy, additional, Bosworth, Alysia, additional, Francisco, Liton, additional, Schlichting, Elizabeth, additional, Bhatia, Ravi, additional, Salzman, Donna, additional, Wong, F. Lennie, additional, Weisdorf, Daniel J., additional, Forman, Stephen J., additional, Arora, Mukta, additional, and Bhatia, Smita, additional

Published
2022
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32. Trends in Late Mortality and Life Expectancy After Autologous Blood or Marrow Transplantation Over Three Decades: A BMTSS Report

Author

Bhatia, Smita, primary, Dai, Chen, additional, Landier, Wendy, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Siler, Arianna, additional, Funk, Erin, additional, Hicks, Jessica, additional, Lim, Shawn, additional, Balas, Nora, additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Francisco, Liton, additional, Bhatia, Ravi, additional, Salzman, Donna, additional, Goldman, Frederick D., additional, Forman, Stephen J., additional, Weisdorf, Daniel J., additional, Wong, F. Lennie, additional, Armenian, Saro H., additional, and Arora, Mukta, additional

Published
2022
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33. Conditioning Intensity and Chronic Health Conditions (CHCs) after Allogeneic Blood or Marrow Transplantation (BMT): A Report from the BMT Survivor Study (BMTSS)

Author

Wadhwa, Aman, primary, Dai, Chen, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Te, Hok Sreng, additional, Bosworth, Alysia, additional, Balas, Nora, additional, Siler, Arianna, additional, Funk, Erin, additional, Hicks, Jessica, additional, Francisco, Liton, additional, Wong, Lennie, additional, Forman, Stephen J., additional, Weisdorf, Daniel, additional, Armenian, Saro H., additional, Arora, Mukta, additional, and Bhatia, Smita, additional

Published
2022
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36. Conditioning Intensity and Probability of Live Birth after Blood or Marrow Transplantation (BMT): a BMTSS Report

Author

Balas, Nora, primary, Hageman, Lindsey, additional, Wu, Jessica, additional, Francisco, Liton, additional, Ross, Elizabeth Schlichting, additional, Bosworth, Alysia Kristine, additional, Te, Hok Sreng, additional, Wong, F. Lennie, additional, Landier, Wendy, additional, Salzman, Donna, additional, Weisdorf, Daniel J, additional, Forman, Stephen J, additional, Arora, Mukta, additional, Armenian, Saro, additional, and Bhatia, Smita, additional

Published
2021
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37. Severe, life‐threatening, and fatal chronic health conditions after allogeneic blood or marrow transplantation in childhood.

Author

Holmqvist, Anna Sällfors, Chen, Yanjun, Hageman, Lindsey, Landier, Wendy, Wu, Jessica, Francisco, Liton F., Ross, Elizabeth Schlichting, Balas, Nora A., Bosworth, Alysia, Te, Hok Sreng, Goldman, Frederick D., Rosenthal, Joseph, Wong, F. Lennie, Weisdorf, Daniel J., Armenian, Saro H., and Bhatia, Smita

Subjects
CHRONIC diseases, BONE marrow transplantation, TOTAL body irradiation, PROPORTIONAL hazards models, ACUTE myeloid leukemia
Abstract

Background: A comprehensive assessment of morbidity after allogeneic bone marrow transplantation (BMT) performed in childhood remains understudied. Methods: Seven hundred eighty‐nine allogeneic BMT recipients who had survived ≥2 years after BMT performed between 1974 and 2014 at age <22 years and 690 siblings completed a 255‐item survey self‐reporting sociodemographics and chronic health conditions. A severity score (grade 3 [severe], 4 [life‐threatening], or 5 [fatal]) was assigned to the conditions using Common Terminology Criteria for Adverse Events, version 5.0. For the BMT cohort, the cumulative incidence of chronic health conditions was calculated as a function of time from BMT. Proportional subdistribution hazards models were used to determine predictors of grade 3–5 conditions. Logistic regression was used to estimate the risk of grade 3–4 conditions in BMT recipients who were alive at the time of this study compared with siblings. Results: The median age at transplantation was 11.3 years (range, 0.4–22.0 years), and the median length of follow‐up was 11.7 years (range, 2.0–45.3 years). The most prevalent primary diagnoses were acute lymphoblastic leukemia (30.7%), and acute myeloid leukemia/myelodysplastic syndrome (26.9%). At age 35 years, the cumulative incidence of a grade 3–4 condition was 53.8% (95% CI, 46.7%–60.3%). The adjusted odds ratio of a grade 3–4 condition was 15.1 in survivors (95% CI, 9.5–24.0) compared with siblings. The risk of a grade 3–5 condition increased with age at BMT (hazard ratio [HR], 1.03; 95% CI, 1.01–1.05) and was higher among females (HR, 1.27; 95% CI, 1.02–1.59), patients who received total body irradiation (HR, 1.71; 95% CI, 1.27–2.31), and those reporting chronic graft‐versus‐host disease (HR, 1.38; 95% CI, 1.09–1.74). Conclusions: Two‐year survivors of allogeneic BMT in childhood have an increased risk of grade 3–4 chronic health conditions compared with siblings, suggesting the need for long‐term follow‐up. Two‐year survivors of allogeneic bone marrow transplantation in childhood have a substantially increased risk of chronic health conditions compared with siblings. By age 35 years, more than one half of bone marrow transplantation recipients had a severe or life‐threatening chronic health condition. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Potentially inappropriate medications in geriatric blood or marrow transplantation (BMT) survivors: A BMT Survivor Study report.

Author

Sanchez‐Luege, Sebastian, Landier, Wendy, Dai, Chen, Hageman, Lindsey, Ross, Elizabeth S., Balas, Nora A., Bosworth, Alysia, Te, Hok Sreng, Wu, Jessica, Francisco, Liton, Wong, F. Lennie, Forman, Stephen J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita

Subjects
INAPPROPRIATE prescribing (Medicine), GRAFT versus host disease, BONE marrow, LOGISTIC regression analysis, OLDER people
Abstract

Background: Blood or marrow transplantation (BMT) is increasingly offered to older individuals with hematologic malignancies. The high prevalence of chronic health conditions in such individuals necessitates use of multiple medications. Beers Criteria represent a list of potentially inappropriate medications (PIMs) shown to increase the risk of health problems in the elderly. We sought to determine the prevalence and predictors of PIM use in older BMT survivors and identify associations with health problems. Methods: Study participants were drawn from the BMT Survivor Study, a cohort study of patients transplanted at three US transplant centers between 1974 and 2014 and surviving ≥2 years. For this report, the survivors were aged ≥65 years. Siblings served as a comparison group. Participants self‐reported sociodemographics, chronic health conditions, and medication use. Logistic regression analyses identified predictors of PIM use and associations with health problems. Results: Overall, PIM use was comparable between BMT survivors (49.4%) and siblings (49.3%) (odds ratio [OR] = 0.9; 95% CI, 0.7–1.2); however, BMT survivors were more likely to use >1 PIM (17.4% vs. 12.4%; OR = 1.5; 95% CI, 1.01–2.4) and central nervous system–related PIMs (8.3% vs. 4.3%; OR = 2.18; 95% CI, 1.17–4.09). Predictors of PIM use included presence of severe/life‐threatening chronic health conditions (OR = 1.5; 95% CI, 1.1–2.0), and chronic graft versus host disease (OR = 1.7; 95% CI, 1.1–2.7). Survivors taking >1 PIM reported more issues with vertigo (OR = 2.3; 95% CI, 1.1–4.7), balance (OR = 2.6; 95% CI, 1.7–4.1), faintness/dizziness (OR = 2.8; 95% CI, 1.8–4.6), and personal care (OR = 4.5; 95% CI, 1.4–14.8). Conclusions: This study shows the health problems associated with PIM use and identifies vulnerable populations at higher risk for PIM use, providing evidence for caution in using PIMs in high‐risk populations. Older blood or marrow transplantation survivors were more likely to use multiple potentially inappropriate medications than a sibling comparison group. Survivors with multimorbidity and/or chronic graft versus host disease were more likely to use these medications; survivors taking multiple potentially inappropriate medications reported several health problems. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Trends in Late Mortality and Life Expectancy after Autologous Blood or Marrow Transplantation (BMT) Performed over Three Decades - a BMT Survivor Study (BMTSS) Report

Author

Arora, Mukta, primary, Dai, Chen, additional, Landier, Wendy, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Siler, Arianna, additional, Funk, Erin, additional, Hicks, Jessica, additional, Balas, Nora, additional, Bosworth, Alysia, additional, Sreng Te, Hok, additional, Francisco, Liton F., additional, Bhatia, Ravi, additional, Salzman, Donna, additional, Goldman, Frederick, additional, Forman, Stephen J, additional, Weisdorf, Daniel J., additional, Wong, Lennie, additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2021
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40. Conditioning Intensity and Probability of Live Birth after Blood or Marrow Transplantation (BMT) - a Report from the BMT Survivor Study (BMTSS)

Author

Balas, Nora, primary, Hageman, Lindsey, additional, Wu, Jessica, additional, Francisco, Liton F., additional, Schlichting, Elizabeth, additional, Bosworth, Alysia, additional, Sreng Te, Hok, additional, Wong, Lennie, additional, Landier, Wendy, additional, Salzman, Donna, additional, Weisdorf, Daniel J., additional, Forman, Stephen J, additional, Arora, Mukta, additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2021
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41. Association between Neighborhood Disadvantage and Health Status/Healthcare Utilization in Survivors of Blood or Marrow Transplantation (BMT) - a BMTSS Report

Author

Wolfson, Julie A., primary, Bhatia, Smita, additional, Hageman, Lindsey, additional, Schlichting, Elizabeth, additional, Balas, Nora, additional, Francisco, Liton F., additional, Funk, Erin, additional, Hicks, Jessica, additional, Landier, Wendy, additional, Siler, Arianna, additional, Bosworth, Alysia, additional, Armenian, Saro H., additional, Arora, Mukta, additional, Sreng Te, Hok, additional, Aswani, Monica A., additional, and Wu, Jessica, additional

Published
2021
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42. Subsequent Malignant Neoplasms of the Gastrointestinal Tract after Blood or Marrow Transplantation - a BMTSS Report

Author

McDonald, Andrew, primary, Dai, Chen, additional, Hageman, Lindsey, additional, Landier, Wendy, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Balas, Nora, additional, Francisco, Liton F., additional, Bosworth, Alysia, additional, Sreng Te, Hok, additional, Wong, Lennie, additional, Salzman, Donna, additional, Bhatia, Ravi, additional, Weisdorf, Daniel J., additional, Forman, Stephen J, additional, Arora, Mukta, additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2021
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43. Trends in Late Mortality and Life Expectancy After Allogeneic Blood or Marrow Transplantation Over 4 Decades

Author

Bhatia, Smita, primary, Dai, Chen, additional, Landier, Wendy, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Schlichting, Elizabeth, additional, Siler, Arianna, additional, Funk, Erin, additional, Hicks, Jessica, additional, Bosworth, Alysia, additional, Te, Hok Sreng, additional, Francisco, Liton, additional, Bhatia, Ravi, additional, Salzman, Donna, additional, Goldman, Frederick D., additional, Forman, Stephen J., additional, Weisdorf, Daniel J., additional, Wong, F. Lennie, additional, Arora, Mukta, additional, and Armenian, Saro H., additional

Published
2021
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46. Clonal Hematopoiesis Is Associated with Cardiovascular Disease Risk and Worse Survival after Autologous Hematopoietic Cell Transplantation for Lymphoma

Author

Rhee, June-Wha, Pillai, Raju, Chen, Sitong, Bosworth, Alysia, Atencio, Liezl, Oganesyan, Artem, Freeman, Kendall, Guzman, Tati, Lukas, Kara, Peng, Kelly, Sigala, Brianna, Iujuridze, Aleksi, Lindenfeld, Lanie, Jamal, Faizi, Herrera, Alex F., Mei, Matthew G., Nakamura, Ryotaro, Wong, F. Lennie, Forman, Stephen J., and Armenian, Saro

Published
2023
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47. Association between learning and memory problems and health outcomes after blood or marrow transplantation (BMT): A BMT survivor study (BMTSS) report.

Author

Murdaugh, Donna, primary, Sharafeldin, Noha, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Bosworth, Alysia, additional, Landier, Wendy, additional, Weisdorf, Daniel Jordan, additional, Forman, Stephen J., additional, Armenian, Saro, additional, Arora, Mukta, additional, and Bhatia, Smita, additional

Published
2021
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48. Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia (AML) Treated with Blood or Marrow Transplantation (BMT) – Results of the BMT Survivor Study (BMTSS)

Author

Armenian, Saro, primary, Chen, Yanjun, additional, Hageman, Lindsay, additional, Wu, Jessica, additional, Landier, Wendy, additional, Bosworth, Alysia, additional, Francisco, Liton, additional, Schlichting, Elizabeth, additional, Bhatia, Ravi, additional, Salzman, Donna, additional, Wong, Lennie, additional, Weisdorf, Daniel J., additional, Forman, Stephen J., additional, Arora, Mukta, additional, and Bhatia, Smita, additional

Published
2021
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49. Longitudinal trajectory of frailty in blood or marrow transplant survivors: Report from the Blood or Marrow Transplant Survivor Study

Author

Arora, Mukta, primary, Chen, Yanjun, additional, Wu, Jessica, additional, Hageman, Lindsey, additional, Ness, Emily, additional, Kung, Michelle, additional, Francisco, Liton, additional, Bosworth, Alysia, additional, Weisdorf, Daniel J., additional, Forman, Stephen J., additional, Landier, Wendy, additional, Pamukçuoğlu, Merve, additional, Armenian, Saro H., additional, Wong, F. Lennie, additional, and Bhatia, Smita, additional

Published
2020
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50. Morbidity burden in survivors of multiple myeloma who underwent autologous transplantation: A Bone Marrow Transplantation Survivor Study

Author

Arora, Mukta, primary, Chen, Yanjun, additional, Hageman, Lindsey, additional, Wu, Jessica, additional, Landier, Wendy, additional, Francisco, Liton, additional, Kung, Michelle, additional, Ness, Emily, additional, Bosworth, Alysia, additional, Pamukcuoglu, Merve, additional, Weisdorf, Daniel J., additional, Forman, Stephen J., additional, Armenian, Saro H., additional, and Bhatia, Smita, additional

Published
2020
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