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1. Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.

Author

Wang, Minggui, Ge, Lizhao, Chen, Liang, Komarow, Lauren, Hanson, Blake, Reyes, Jinnethe, Cober, Eric, Alenazi, Thamer, Zong, Zhiyong, Xie, Qing, Liu, Zhengyin, Li, Lanjuan, Yu, Yunsong, Gao, Hainv, Kanj, Souha, Figueroa, Jairo, Herc, Erica, Cordova, Ezequiel, Weston, Gregory, Ananth Tambyah, Paul, Garcia-Diaz, Julia, Kaye, Keith, Dhar, Sorabh, Munita, Jose, Salata, Robert, Vilchez, Samuel, Stryjewski, Martin, Villegas Botero, Maria, Iovleva, Alina, Evans, Scott, Baum, Keri, Hill, Carol, Kreiswirth, Barry, Patel, Robin, Paterson, David, Arias, Cesar, Bonomo, Robert, Chambers, Henry, Fowler, Vance, Satlin, Michael, van Duin, David, and Doi, Yohei

Subjects
carbapenem-resistant Acinetobacter baumannii, clinical impact, international epidemiology, Humans, Acinetobacter baumannii, Carbapenems, Prospective Studies, Microbial Sensitivity Tests, Acinetobacter Infections, beta-Lactamases, Bacterial Proteins, Anti-Bacterial Agents
Abstract

BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the most problematic antimicrobial-resistant bacteria. We sought to elucidate the international epidemiology and clinical impact of CRAb. METHODS: In a prospective observational cohort study, 842 hospitalized patients with a clinical CRAb culture were enrolled at 46 hospitals in five global regions between 2017 and 2019. The primary outcome was all-cause mortality at 30 days from the index culture. The strains underwent whole-genome analysis. RESULTS: Of 842 cases, 536 (64%) represented infection. By 30 days, 128 (24%) of the infected patients died, ranging from 1 (6%) of 18 in Australia-Singapore to 54 (25%) of 216 in the United States and 24 (49%) of 49 in South-Central America, whereas 42 (14%) of non-infected patients died. Bacteremia was associated with a higher risk of death compared with other types of infection (40 [42%] of 96 vs 88 [20%] of 440). In a multivariable logistic regression analysis, bloodstream infection and higher age-adjusted Charlson comorbidity index were independently associated with 30-day mortality. Clonal group 2 (CG2) strains predominated except in South-Central America, ranging from 216 (59%) of 369 in the United States to 282 (97%) of 291 in China. Acquired carbapenemase genes were carried by 769 (91%) of the 842 isolates. CG2 strains were significantly associated with higher levels of meropenem resistance, yet non-CG2 cases were over-represented among the deaths compared with CG2 cases. CONCLUSIONS: CRAb infection types and clinical outcomes differed significantly across regions. Although CG2 strains remained predominant, non-CG2 strains were associated with higher mortality. Clinical Trials Registration. NCT03646227.

Published
2024

4. Carbapenem-resistant Enterobacterales in solid organ transplant recipients

Author

Kanj, Souha S., Francois (Jeff) Jabbour, Jean, Zhang, Fujie, Lok, Judith J., Salata, Robert A., Stryjewski, Martin, Di Castelnuovo, Valentina, Oñate Gutierrez, Jose Millan, Cober, Eric, Richter, Susan, Anderson, Deverick J., Evans, Beth, Hill, Carol, Cross, Heather R., Baum, Keri, Arias, Rebekka, Fowler, Vance G., Jr., Ordoñez, Karen, Jacob, Jesse T., Li, Linghua, Kreiswirth, Barry N., Manca, Claudia, Chen, Liang, Desai, Samit, Herc, Erica, Cordova, Ezequiel, Rioseco, Maria, Vichez, Samuel, Sanchez, Marisa L., Valderrama, Sandra, Figueroa, Jairo, Arias, Cesar A., Dinh, An Q., Panesso, Diane, Rydell, Kirsten, Tran, Truc T., Hu, Fupin, Su, Jiachun, Jiang, Jianping, Wang, Minggui, Xu, Xiaogang, Yang, Yang, Munita, Jose M., Spencer, Maria, Alenazi, Thamer, Bonomo, Robert A., Marshall, Steven H., Rudin, Susan D., Huskins, Charles, Kerry, Patel, Robin, Schmidt-Malan, Suzannah, Revolinski, Sara, Wortmann, Glenn, Kalayjian, Robert C., Weston, Greg, Ostrowsky, Belinda, Patel, Gopi, Eiras, Daniel, Kim, Angela, Garcia-Diaz, Julia, Salcedo, Soraya, Farrell, John J., Liu, Zhengyin, Henderson, Andrew, Paterson, David L., Xie, Qing, Kaye, Keith S., Gao, Hainv, Yu, Yunsong, Waters, Mary, Fries, Bettina C., Eilertson, Brandon, Marimuthu, Kalisvar, Lee Chew, Kean, Smitasin, Nares, Tambyah, Paul Ananth, Gallagher, Jason C., Peleg, Anton, Leroi, Marcel, Li, Lanjuan, Komarow, Lauren, Ge, Lizhao, Evans, Scott, McCarty, Todd, Chambers, Henry F., Garner, Omai B., Abbo, Lilian M., van Duin, David, Lautenbach, Ebbing, Han, Jennifer H., Doi, Yohei, Wong, Darren, Hanson, Blake, Reyes, Jinnethe, Villegas Botero, Maria Virginia, Diaz, Lorena, Perez, Federico, Banerjee, Ritu, Dhar, Sorabh, Satlin, Michael J., Zong, Zhiyong, Boutzoukas, Angelique E., Dai, Weixiao, Grant, Matthew, and McCarty, Todd P.

Published
2024
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7. Primate Orphans

Author

Botero, Maria, Vonk, Jennifer, Section editor, Vonk, Jennifer, editor, and Shackelford, Todd K., editor

Published
2022
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9. Methodological Considerations for Comparison of Cross-species Use of Tactile Contact

Author

Dudzinski, Kathleen M, Hill, Heather M, and Botero, Maria

Subjects
dolphin, chimpanzee, tactile contact, touch, cross-species comparisons, mother-offspring interaction
Abstract

Cross-species comparisons are benefited by compatible datasets; conclusions related to phylogenetic comparisons, questions on convergent and divergent evolution, or homologs versus analogs can only be made when the behaviors being measured are comparable. A direct comparison of the social function of physical contact across two disparate taxa is possible only if data collection and analyses methodologies are analogous. We identify and discuss the parameters, assumptions and measurement schemes applicable to multiple taxa and species that facilitate cross-species comparisons. To illustrate our proposed guidelines for evaluating the role played by tactile contact in social behavior across disparate taxa, this paper presents data on mother-offspring relationships in the two species studied by the authors: chimpanzees (Pan troglodytes schweinfurthii) and dolphins (bottlenose and spotted, Tursiops truncatus and Stenella frontalis, respectively). Cross-species comparative studies allow for a more comprehensive assessment of the similarities and differences with respect to how animals traverse the relationships that form their social groups and societies.

Published
2019

11. Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study

Author

Abbo, Lilian M, Anderson, Deverick J, Arias, Rebekka, Arias, Cesar A, Baum, Keri, Bonomo, Robert A, Chambers, Henry F, Chen, Liang, Chew, Kean Lee, Cober, Eric, Cross, Heather R, De, Partha Pratim, Desai, Samit, Dhar, Sorabh, Di Castelnuovo, Valentina, Diaz, Lorena, Dinh, AN Q, Doi, Yohei, Earley, Michelle, Eilertson, Brandon, Evans, Beth, Evans, Scott, Fowler Jr, Vance G, Fries, Bettina C, Gao, Hainv, Garcia-Diaz, Julia, Garner, Omai B, Greenwood-Quaintance, Kerryl, Hanson, Blake, Herc, Erica, Hill, Carol, Jacob, Jesse T, Jiang, Jianping, Kalayjian, Robert C, Kanj, Souha S, Kaye, Keith S, Kim, Angela, Komarow, Lauren, Kreiswirth, Barry N, Lauterbach, Courtney, Li, Lanjuan, Liu, Zhengyin, Manca, Claudia, Marimuthu, Kalisvar, Marshall, Steven H, McCarty, Todd, Munita, Jose, Ng, Oon Tek, Oñate Gutierrez, Jose Millan, Ordoñez, Karen, Patel, Robin, Paterson, David L, Peleg, Anton, Reyes, Jinnethe, Rudin, Susan D, Salata, Robert A, Salcedo, Soraya, Satlin, Michael J, Schmidt-Malan, Suzannah, Smitasin, Nares, Spencer, Maria, Stryjewski, Martin, Su, Jiachun, Tambyah, Paul Ananth, Valderrama, Sandra, van Duin, David, Villegas Botero, Maria Virginia, Wang, Minggui, Waters, Mary, Weston, Greg, Wong, Darren, Wortmann, Glenn, Yang, Yang, Yu, Yunsong, Zhang, Fujie, Hanson, Blake M, Munita, Jose M, Valderrama-Beltrán, Sandra L, Stryjewski, Martin E, Luterbach, Courtney, Marshall, Steve H, Villegas, Maria V, and Fowler, Vance G, Jr

Published
2022
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12. Expanding Perception: The Role of Touch in Comparative Psychology; Introduction to the Special Issue

Author

Botero, Maria

Abstract

In recent years, researchers have begun to include diverse modes of perception in comparative studies, such as vocal and tactile forms of communication, in an effort to understand social, cognitive, and affective processes in various species. In this special issue, we have collected a series of articles that approach from an interdisciplinary perspective (i.e., psychology, behavioral sciences, anthropology, and philosophy) how touch/contact has been included in diverse fields of research and exploring the new insights produced by including this mode of perception.

Published
2018

13. Bringing Touch Back to the Study of Emotions in Human and Non-Human Primates: A Theoretical Exploration

Author

Botero, Maria

Subjects
Mother-infant interaction, Expression of Emotions, Touch, Primates
Abstract

This paper provides a theoretical exploration of how comparative research on the expression of emotions has traditionally focused on the visual mode and argues that, given the neurophysiological, developmental, and behavioral evidence that links touch with social interactions, focusing on touch can become an ideal mode to understand the communication of emotions in human and non-human primates. This evidence shows that touch is intrinsically linked with social cognition because it motivates human and non-human animals, from birth, to form social bonds. It will be shown that touch is one of the modes of interaction used by the mother-infant or caregiver-infant dyad that facilitates the expression of emotions by the infant (and later the expression of emotions by the adult that the infant has become) in ways that are understood by other members of the group.

Published
2018

36. Parent-child communication about substance use, puberty, sex, and social media use among Hispanic parents and pre-adolescent children.

Author

Matsuda, Yui, Thalasinos, Roxana D., Parra, Alexa, Roman Laporte, Roberto, Mejia-Botero, Maria A., Adera, Abgail L., Siles, Melody, Lazaro, Gerardo, Venkata, Ronak N., and De Santis, Joseph P.

Subjects
PARENT-child communication, SUBSTANCE abuse, TEENAGE parents, SOCIAL media, TEENAGE boys, FAMILY communication, PARENTS
Abstract

Background & purpose: Previous research has noted that Hispanic pre-adolescents may be at an increased probability for engagement in risk-taking behaviors. The purpose of this study was to explore parent-child communication among Hispanic parents and 4th-6th grade children related to substance use, puberty, sex, and social media use. Methods: A qualitative descriptive design was used to examine Hispanic parents'/caregivers' communication with their children about substance use behaviors, pubertal developments, engagement in sexual risk behaviors, and social media use. The study included two components: four focus groups consisting of 23 children; five focus groups and one interview consisting of 24 adults. All were conducted until data saturation was reached. Parents and pre-adolescents were interviewed separately. Interviews with parents and pre-adolescents were audio-recorded, transcribed verbatim, and analyzed using content analysis techniques. Results & conclusion: The themes that emerged from the interviews were about children's feelings, parents' feelings, communication messages that children received from their parents, and information parents provided to their children during parent-child communication. The results indicate discrepancies between information that parents provided and information that the pre-adolescents reported. The results have implications for healthcare providers in that parents need to be better educated on communicating effectively with their pre-adolescents about risk-taking behaviors. Healthcare providers may help facilitate parent-child communication with Hispanic families. More research is needed to develop intervention programs for Hispanic parents to learn how to effectively communicate with their pre-adolescent children in a developmentally appropriate manner. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Data from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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38. Supplementary Legends 1-4 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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39. Supplementary Figure 1 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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40. Supplementary Figure 2 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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41. Supplementary Figure 3 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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42. Supplementary Figure 4 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Author

Serra, Violeta, primary, Markman, Ben, primary, Scaltriti, Maurizio, primary, Eichhorn, Pieter J.A., primary, Valero, Vanesa, primary, Guzman, Marta, primary, Botero, Maria Luisa, primary, Llonch, Elisabeth, primary, Atzori, Francesco, primary, Di Cosimo, Serena, primary, Maira, Michel, primary, Garcia-Echeverria, Carlos, primary, Parra, Josep Lluis, primary, Arribas, Joaquin, primary, and Baselga, José, primary

Published
2023
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49. Propuesta de diseño del programa de vigilancia epidemiológico para la prevención de desórdenes músculo esqueléticos en el área administrativa de la empresa EPP Seguridad Industrial S.A.S

Author

Arango Botero, Maria José, Padilla Payares, Leidis, Roa Sánchez, Jessika Johanna, and Moncada Rodríguez, Luz Marleny

Subjects
Encuesta nórdica, Seguridad en el trabajo, Programa de vigilancia epidemiológico, Desórdenes músculo esqueléticos, Epidemiological surveillance program, Occupational safety, Musculoskeletal disorders, Nordic survey
Abstract

En la investigación se buscó establecer medidas enfocadas a la prevención de desórdenes músculo esqueléticas en los trabajadores del área administrativa de la empresa EPP Seguridad Industrial S.A.S. para el diseño de un programa de vigilancia epidemiológico. Para el desarrollo del proyecto se utilizó el perfil sociodemográfico, las estadísticas de ausentismo, la matriz IPEVR precocinados por la empresa y se aplicó la encuesta nórdica y la evaluación de los puestos de trabajo por medio de la “Guía de ergonomía. Identificación y control de factores de riesgo en el trabajo de oficina y el uso de computador” del del Instituto de Salud Pública de Chile del 2016, para conocer las condiciones de laborales de los trabajadores de la empresa EPP Seguridad Industrial S.A.S. En la investigación se encontró, que de los 5 trabajadores 2 de ellos (hombres) del área administrativa con formación bachiller y profesional; manifiestan dolor en el área del cuerpo dorsal o lumbar en los últimos 12 meses, la cual tiene un promedio de duración entre 1 a 7 días, aunque no han requerido incapacidad o ni han sido diagnosticados de enfermedad laboral de este tipo, lo que evidencia lo encontrado en la matriz de peligros, donde se encontró el peligro biomecánico con un nivel de riesgo medio, el cual está relacionado directamente por movimiento repetitivo, posturas sedentes prolongadas y mantenidas, las cuales están llevados a que se generen lesiones osteomusculares y por ende baja productividad del personal y demora en los procesos. Palabras claves: Programa de vigilancia epidemiológico, desórdenes músculo esqueléticos, encuesta nórdica, evaluación de puestos de trabajo, diseño de puestos de trabajo. Tabla de Contenidos Lista de Tablas x Lista de Figuras xi Lista de Anexos xii 2. Planteamiento del Problema 1 2.1 Descripción del Problema 1 2.2 Formulación del Problema 2 2.3 Delimitación o Alcance del Problema . 3. Objetivo 4 3.1 Objetivo General 4 3.2 Objetivos Específicos 4 4. Justificación y Delimitación 5 4.1 Justificación 5 4.2 Delimitación 7 4.3 Limitaciones 7 5. Marco de Referencia 8 5.1 Estado del Arte 8 5.2 Marco Teórico 22 5.3 Marco Legal 37 6. Marco Metodológico de la Investigación 43 6.1 Fases del estudio 43 6.2 Recolección de la Información 44 7. Resultados y discusión. 51 7.1 Resultados 51 7.2 Análisis de Resultados 64 7.3 Propuesta de Solución 66 7.4 Entrega de Resultados 76 8. Análisis Financiero 93 9. Conclusiones y Recomendaciones 97 9.1 Conclusiones 97 9.2 Recomendaciones 99 10. Referencias Bibliográficas 101 Especialización Especialista en Gerencia de la Seguridad y Salud en el Trabajo Especialización en Gerencia de la Seguridad y Salud en el Trabajo

Published
2022

50. OS-010 Endothelial-to-mesenchymal transition: a targetable mechanism involved in portal vein thrombosis in cirrhosis

Author

Anton, Aina, Campreciós, Genís, Shalaby, Sarah, Botero, María Luisa, Blasi, Annabel, Fundora, Yilliam, Barace, Sergio, Montañés, Rosa, García-Calderó, Héctor, Orts, Lara, Montironi, Carla, Olivas, Pol, Crespo, Gonzalo, Bazán, Cynthia, Zambrano-Huailla, Rommel, Tura-Ceida, Olga, Argemi, Josep Maria, García-Pagán, Juan Carlos, and Hernández-Gea, Virginia

Published
2024
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