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102 results on '"Botnaru, Victor"'

13. Placebo effects in pharmaceutical clinical trials in bronchiectasis: an EMBARC study

Author

Gao, Yonghua, primary, Lonergan, Mike, additional, Abo-Leyah, Hani, additional, Aliberti, Stefano, additional, Menendez, Rosario, additional, Blasi, Francesco, additional, Regis-Burgel, Pierre, additional, Ringshausen, Felix, additional, De Soyza, Anthony, additional, Vendrell, Montserrat, additional, Polverino, Eva, additional, Skrgat, Sabina, additional, Van Der Eerden, Menno, additional, Boersma, Wim, additional, Sibila, Oriol, additional, Mcdonnell, Melissa, additional, Kauppi, Paula, additional, Botnaru, Victor, additional, Van Braeckel, Eva, additional, Lorent, Natalie, additional, Rademacher, Jessica, additional, Haworth, Charles, additional, Dimakou, Katerina, additional, Loebinger, Michael R, additional, Torres, Antoni, additional, Welte, Tobias, additional, Stuart Elborn, J, additional, Crichton, Megan L, additional, Goeminne, Pieter C, additional, Shteinberg, Michal, additional, Shoemark, Amelia, additional, Altenburg, Josje, additional, and Chalmers, James D, additional

Published
2020
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14. Alpha-1 antitrypsin deficiency in patients with bronchiectasis: data from the European Bronchiectasis Registry EMBARC

Author

Loebinger, Michael, primary, Aliberti, Stefano, additional, Menendez, Rosario, additional, Blasi, Francesco, additional, Burgel, Pierre-Regis, additional, Ringshausen, Felix, additional, Trautmann, Marion, additional, Davis, Angela, additional, De Soyza, Anthony, additional, Shteinberg, Michal, additional, Shoemark, Amelia, additional, Altenburg, Josje, additional, Chalmers, James D, additional, Vendrell, Montserrat, additional, Polverino, Eva, additional, Skrgat, Sabina, additional, Van Der Eerden, Menno, additional, Boersma, Wim, additional, Sibila, Oriol, additional, Mcdonnell, Melissa, additional, Maiz, Luiz, additional, Kauppi, Paula, additional, Botnaru, Victor, additional, Van Braeckel, Eva, additional, Lorent, Natalie, additional, Rademacher, Jessica, additional, Haworth, Charles, additional, Dimakou, Katerina, additional, Torres, Antoni, additional, Welte, Tobias, additional, Elborn, Stuart, additional, and Goeminne, Pieter, additional

Published
2020
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18. COPD and comorbidities in the Republic of Moldova.

Author

Corlateanu, Alexandru, Covantsev, Serghei, Scutaru, Eugenia, Rusu, Doina, Botnaru, Victor, Corlateanu, Olga, and Siafakas, Nikolaos

Subjects
CHRONIC obstructive pulmonary disease, BODY mass index, HEART failure patients, CORONARY artery disease, COMORBIDITY
Abstract

BACKGROUND AND AIM: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide, and the majority of patients have at least one comorbid condition of clinical significance. Therefore, we studied its prevalence and implication based on experience from the Republic of Moldova. METHODS: The study was a prospective cohort study that included 435 patients with COPD from 2015 to 2017. RESULTS: We found heart failure in 38.62% of the patients, hypertension in 50.11%, coronary artery disease in 23.45%, diabetes mellitus in 10.11%, renal failure in 1.15%, rheumatoid arthritis in 3.22%, depression in 4.83%, cognitive impairment in 4.37%, obesity in 29.89%, and cachexia in 3.22%. Only 24.65% of patients did not have comorbidities. One comorbidity was found in 23.73%, two in 24.19%, three or more in 27.42%. The Charlson comorbidity index (CCI) had a medium negative correlation with the 6-minute walking test (r=–0.37, p<0.001) and a weak correlation with the rate of exacerbations (r=0.17, p=0.016). CCI had a strong correlation with ADO (age, dyspnea and airflow obstruction) (r=0.75, p<0.001); moderate with BODE (body mass index, airflow obstruction, dyspnea, and exercise) (r=0.3, p<0.001); and weak with BODEx (body mass index, airflow obstruction, dyspnea, and exacerbations), CODEX (comorbidity, obstruction, dyspnea, and previous severe exacerbations), and DOSE (dyspnea, obstruction, smoking, and exacerbation). CCI had a medium correlation with St. George’s Respiratory Questionnaire (SGRQ) activity (r=0.36, p<0.001), impact (r=0.34, p<0.001), and total (r=0.37, p<0.001) scores, and the overall quality of life assessed by SGRQ and Clinical COPD Questionnaire. CONCLUSIONS: Patients with COPD require a multidisciplinary approach to assess and manage a variety of conditions, which influence the evolution and prognosis of COPD. Patients often have one or two comorbidities of clinical significance, and they are predominantly cardiovascular and metabolic. Patients with comorbidities tend to have a poorer health-related quality of life. Comorbidities can be assessed by multidimensional indexes such as ADO and BODE. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Asthma-COPD Overlap: A more Simplistic Approach

Author

Corlateanu, Alexandru, Covantev, Serghei, Botnaru, Victor, Dumitru, Silvia, and Corlateanu, Olga

Abstract

Obstructive pulmonary diseases are a group of respiratory conditions characterized by airflow limitation. They are prevalent in the population and lead to significant morbidity and mortality. The two most commonly encountered conditions are asthma and Chronic Obstructive Pulmonary Disease (COPD). Although, for many years, the two conditions were regarded as separate, it was realized that some patients may have an overlap between these illnesses. This observation led to the identification of asthma-COPD overlap (ACO) syndrome. ACO is an umbrella term that is used “to collectively describe patients who have persistent airflow limitation together with clinical features that are consistent with both asthma and COPD”. Its importance in the field of respiratory medicine is increasing every year as there are more data that underline the importance of its timely diagnosis and management. The current review is a timely update of the advances in our understanding of ACO.

Published
2021
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39. The EMBARC European Bronchiectasis Registry: protocol for an international observational study

Author

Chalmers, James D., primary, Aliberti, Stefano, additional, Polverino, Eva, additional, Vendrell, Montserrat, additional, Crichton, Megan, additional, Loebinger, Michael, additional, Dimakou, Katerina, additional, Clifton, Ian, additional, van der Eerden, Menno, additional, Rohde, Gernot, additional, Murris-Espin, Marlene, additional, Masefield, Sarah, additional, Gerada, Eleanor, additional, Shteinberg, Michal, additional, Ringshausen, Felix, additional, Haworth, Charles, additional, Boersma, Wim, additional, Rademacher, Jessica, additional, Hill, Adam T., additional, Aksamit, Timothy, additional, O'Donnell, Anne, additional, Morgan, Lucy, additional, Milenkovic, Branislava, additional, Tramma, Leandro, additional, Neves, Joao, additional, Menendez, Rosario, additional, Paggiaro, Perluigi, additional, Botnaru, Victor, additional, Skrgat, Sabina, additional, Wilson, Robert, additional, Goeminne, Pieter, additional, De Soyza, Anthony, additional, Welte, Tobias, additional, Torres, Antoni, additional, Elborn, J. Stuart, additional, and Blasi, Francesco, additional

Published
2016
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