1,150 results on '"Bottini, P."'
Search Results
2. O'Grady's tenfolds from stable bundles on hyper-K\'ahler fourfolds
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Bottini, Alessio
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Mathematics - Algebraic Geometry - Abstract
We provide a modular construction of the Laza--Sacc\`a--Voisin compactification of the intermediate Jacobian fibration of a cubic fourfold. Additionally, we construct infinitely many $20$-dimensional families of polarized hyper-K\"ahler manifolds of type OG10, realized as moduli spaces of stable bundles on hyper-K\"ahler manifolds of type $\mathrm{K3}^{[2]}$., Comment: v.2 added Lemma 3.2 for clarity and corrected typos. 52 pages
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- 2024
3. A Gapless Phase with Haagerup Symmetry
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Bottini, Lea E. and Schafer-Nameki, Sakura
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High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Mathematical Physics ,Mathematics - Category Theory ,Mathematics - Quantum Algebra - Abstract
We construct a (1+1)d gapless theory which has Haagerup $\mathcal{H}_3$ symmetry. The construction relies on the recent exploration of the categorical Landau paradigm applied to fusion category symmetries. First, using the Symmetry Topological Field Theory, we construct all gapped phases with Haagerup symmetry. Extending this construction to gapless phases, we study the second order phase transition between gapped phases, and determine analytically an Haagerup-symmetric conformal field theory. This is given in terms of two copies of the three-state Potts model, on which we realise the full $\mathcal{H}_3$ symmetry action and determine the relevant deformations to the $\mathcal{H}_3$-symmetric gapped phases. This continuum analysis is corroborated by a lattice model construction of the gapped and gapless phases, using the anyon chain., Comment: 11 pages + appendices, 2 figures; v2: references added
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- 2024
4. Behavioral Parent Training via Telehealth for Autistic Children in Rural Appalachia: A Mixed Methods Feasibility Study
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Kait Gould, Ryan J. Martin, Summer Bottini, Jaime Crowley-Zalaket, Ainsley Losh, Meka McCammon, Jennifer R. Wolgemuth, and Cynthia Anderson
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Behavioral parent training (BPT) is an empirically supported approach for addressing the behavioral concerns of autistic children. However, many families face barriers to accessing BPT. Adapting BPT via telehealth technology may improve access for families, especially those living in rural regions. This study aims to evaluate the implementation of a Research Units in Behavioral Intervention (RUBI), a BPT program for autistic children, via telehealth to families living in the Appalachian region of the United States. We employed a mixed-methods approach to examine the feasibility and potential efficacy of implementing the Research Units in Behavioral Intervention Autism Network parent training via telehealth (RUBI-T) with seven rural parent-child dyads. RUBI-T was found to be feasible and satisfactory to parents and community providers. RUBI-T also shows promise for reducing children's disruptive behavior, improving children's adaptive skills, and reducing parent stress, although a more thorough evaluation of its efficacy is warranted. The limitations and implications of the results are discussed.
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- 2024
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5. Dissecting the significance of ACP1 gene alterations in prostate cancer (PCa).
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Abdallah, Nour, Elliott, Andrew, Nabhan, Chadi, Stanford, Stephanie M, Agarwal, Neeraj, Bagrodia, Aditya, Garje, Rohan, Bottini, Nunzio Bottini, and McKay, Rana R
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Human Genome ,Prostate Cancer ,Cancer ,Cancer Genomics ,Genetics ,Urologic Diseases ,Aging ,2.1 Biological and endogenous factors ,Clinical Sciences ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
5025 Background: The acid phosphatase 1 ( ACP1) gene encodes low molecular weight protein tyrosine phosphatase (LMPTP), which is overexpressed in PCa. Previous studies demonstrate that LMPTP plays a critical role in PCa growth and metastasis and is evolving as a potential therapeutic target. Thus, we analyzed ACP1 expression in primary and metastatic PCa samples and the association of ACP1 with molecular profiles and clinical outcomes. Methods: NextGen sequencing of DNA (592-gene/whole exome) and RNA (whole transcriptome) was performed for PCa specimens (n=5028) submitted to Caris Life Sciences. ACP1-High/Low expression was defined as quartile 4 (Q4) and 1 (Q1) of RNA transcripts per million (TPM). DNA mutational profiles were analyzed for samples stratified by ACP1 expression quartiles. Gene set enrichment analysis was used to assess the Hallmark collection of cancer pathways. Tumor cell PD-L1+ status (≥2+, ≥5%; SP142) was tested by immunohistochemistry. Immune cell fractions in the tumor microenvironment (TME) were estimated by RNA deconvolution using QuanTIseq. Overall survival (OS) was assessed from the time of specimen collection to death or last follow-up, with hazard ratio (HR) calculated using the Cox proportional hazards model, and P values calculated using the log-rank test. Results: Samples included 3058 (60.8%) derived from the prostate, 634 (12.6%) from lymph node metastases (LNM), and 1307 (26.0%) from distant metastases (DM). ACP1 expression was higher in LNM and DM than in the prostate (49.8 and 47.9, respectively, vs 44.1 TPM, p
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- 2024
6. Lattice Models for Phases and Transitions with Non-Invertible Symmetries
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Bhardwaj, Lakshya, Bottini, Lea E., Schafer-Nameki, Sakura, and Tiwari, Apoorv
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Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Mathematical Physics - Abstract
Non-invertible categorical symmetries have emerged as a powerful tool to uncover new beyond-Landau phases of matter, both gapped and gapless, along with second order phase transitions between them. The general theory of such phases in (1+1)d has been studied using the Symmetry Topological Field Theory (SymTFT), also known as topological holography. This has unearthed the infrared (IR) structure of these phases and transitions. In this paper, we describe how the SymTFT information can be converted into an ultraviolet (UV) anyonic chain lattice model realizing, in the IR limit, these phases and transitions. In many cases, the Hilbert space of the anyonic chain is tensor product decomposable and the model can be realized as a quantum spin-chain Hamiltonian. We also describe operators acting on the lattice models that are charged under non-invertible symmetries and act as order parameters for the phases and transitions. In order to fully describe the action of non-invertible symmetries, it is crucial to understand the symmetry twisted sectors of the lattice models, which we describe in detail. Throughout the paper, we illustrate the general concepts using the symmetry category $\mathsf{Rep}(S_3)$ formed by representations of the permutation group $S_3$, but our procedure can be applied to any fusion category symmetry., Comment: 76 pages + appendices; v2: references added, v3: minor changes, v4: corrected typos
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- 2024
7. Illustrating the Categorical Landau Paradigm in Lattice Models
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Bhardwaj, Lakshya, Bottini, Lea E., Schafer-Nameki, Sakura, and Tiwari, Apoorv
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Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Mathematical Physics - Abstract
Recent years have seen the concept of global symmetry extended to non-invertible (or categorical) symmetries, for which composition of symmetry generators is not necessarily invertible. Such non-invertible symmetries lead to a generalization of the standard Landau paradigm. In this work we substantiate this framework by providing a (1+1)d lattice model, whose gapped phases and phase transitions can only be explained by symmetry breaking of non-invertible symmetries., Comment: 4.5 pages + appendices, v2: references added
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- 2024
8. Evaluation of Bi-layer Silk Fibroin Grafts for Inlay Vaginoplasty in a Rat Model
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Nguyen, Travis, Gundogdu, Gokhan, Bottini, Christina, Chaudhuri, Ambika K, and Mauney, Joshua R
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Engineering ,Biomedical Engineering ,Regenerative Medicine ,Transplantation ,Bioengineering ,Women's Health ,Vagina ,Silk fibroin ,Vaginoplasty ,Biomaterial ,Biomedical engineering - Abstract
BackgroundAutologous tissues derived from bowel, buccal mucosa and skin are primarily used to repair or replace diseased vaginal segments as well as create neovaginas for male-to-female transgenders. These grafts are often limited by scarce tissue supply, donor site morbidity and post-operative complications. Bi-layer silk fibroin (BLSF) biomaterials represent potential alternatives for vaginoplasty given their structural strength and elasticity, low immunogenicity, and processing flexibility. The goals of the current study were to assess the potential of acellular BLSF scaffolds for vaginal tissue regeneration in respect to conventional small intestinal submucosal (SIS) matrices in a rat model of vaginoplasty.MethodsInlay vaginoplasty was performed with BLSF and SIS scaffolds (N = 21 per graft) in adult female rats for up to 2 months of implantation. Nonsurgical controls (N = 4) were investigated in parallel. Outcome analyses included histologic, immunohistochemical and histomorphometric evaluations of wound healing patterns; µ-computed tomography (CT) of vaginal continuity; and breeding assessments.ResultsAnimals in both scaffold cohorts exhibited 100% survival rates with no severe post-operative complications. At 2 months post-op, µ-CT analysis revealed normal vaginal anatomy and continuity in both graft groups similar to controls. In parallel, BLSF and SIS grafts also induced comparable constructive remodeling patterns and were histologically equivalent in their ability to support formation of vascularized vaginal neotissues with native tissue architecture, however with significantly less smooth muscle content. Vaginal tissues reconstructed with both implants were capable of supporting copulation, pregnancy and similar amounts of live births.ConclusionsBLSF biomaterials represent potential "off-the-shelf" candidates for vaginoplasty.
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- 2024
9. The 'Assessment of Bullying Experiences Questionnaire' ('ABE') for Neurodivergent Youth: Establishing Scoring Criteria and Clinical Thresholds
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Hannah E. Morton, Summer B. Bottini, Alana J. McVey, Brooke E. Magnus, Jennifer M. Gillis, and Raymond G. Romanczyk
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Neurodivergent youth, such as those with diagnoses of autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD), are frequently victimized by their peers. This bullying victimization may occur in unique ways that are not captured by existing questionnaires. The "Assessment of Bullying Experiences" ("ABE") is a questionnaire specific to neurodivergent youth with acceptable psychometric properties in autistic and non-autistic samples. This study sought to establish scoring criteria and clinical cutoffs for the "ABE." Participants were 335 parents of youth (ages 6-17) characterized as autistic, having ADHD, or from a community comparison sample. Receiver operating characteristic (ROC) analyses were used to (1) compare accuracy of the "ABE" total score in predicting bullying victimization experiences and (2) identify optimal questionnaire cutoffs. Clinical utility of these cutoffs was confirmed using ANCOVA analyses. The "ABE" had good-to-excellent discrimination for bullying victimization across groups. Bullied youth had greater symptoms of anxiety/depression compared to youth who were not bullied; this relationship was partially explained by autism characteristics. "ABE" clinical cutoffs generated bullying victimization prevalence rates consistent with existing literature (50% autism, 28% non-autism). The "ABE" is a useful measure to streamline bullying victimization assessment in neurodivergent youth and inform group-specific intervention.
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- 2024
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10. A climate threshold for ocean deoxygenation during the Early Cretaceous
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Bauer, Kohen W., McKenzie, N. Ryan, Cheung, Chris T. L., Gambacorta, Gabriele, Bottini, Cinzia, Nordsvan, Adam R., Erba, Elisabetta, and Crowe, Sean A.
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- 2024
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11. “We’re underserved, but we do the best we can”: Accessing Behavioral Health Services for Autistic Children in Rural Appalachia
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Martin, Ryan J., Bottini, Summer, Gould, Kait, Losh, Ainsley, Crowley-Zalaket, Jaime, McCammon, Meka N., Wolgemuth, Jennifer R., and Anderson, Cynthia
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- 2024
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12. The Club Sandwich: Gapless Phases and Phase Transitions with Non-Invertible Symmetries
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Bhardwaj, Lakshya, Bottini, Lea E., Pajer, Daniel, and Schafer-Nameki, Sakura
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High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Mathematics - Category Theory - Abstract
We provide a generalization of the Symmetry Topological Field Theory (SymTFT) framework to characterize phase transitions and gapless phases with categorical symmetries. The central tool is the club sandwich, which extends the SymTFT setup to include an interface between two topological orders: there is a symmetry boundary, which is gapped, and a physical boundary that may be gapless, but in addition, there is also a gapped interface in the middle. The club sandwich generalizes so-called Kennedy-Tasaki (KT) transformations. Building on the results in [1, 2] on gapped phases with categorical symmetries, we construct gapless theories describing phase transitions with non-invertible symmetries by applying suitable KT transformations on known phase transitions provided by the critical Ising model and the 3-state Potts model. We also describe in detail the order parameters in these gapless theories characterizing the phase transitions, which are generally mixtures of conventional and string-type order parameters mixed together by the action of categorical symmetries. Additionally, removing the physical boundary from the club sandwiches results in club quiches, which characterize all possible gapped boundary phases with (possibly non-invertible) symmetries that can arise on the boundary of a bulk gapped phase. We also provide a mathematical characterization of gapped boundary phases with symmetries as pivotal tensor functors whose targets are pivotal multi-fusion categories., Comment: 58 pages, v2: typos fixed
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- 2023
13. Tracing the origin of Argentine Malbec wines by sensometrics.
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Urvieta, Roy, Heymann, Hildegarde, Cantu, Annegret, Catania, Aníbal, Buscema, Fernando, Bottini, Rubén, and Fontana, Ariel
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The study of terroir, increasingly popular in scientific circles, remains a challenging field, particularly in terms of sensory analysis. This paper summarizes our own contribution to the field-an approach for tracing the typicity of wines by sensometrics, using the Malbec variety as a case study. This large-scale research fingerprinted 81 wines from 29 parcels from highly contrasting environments (varying climate, elevation, and soils), produced under standardized conditions in three consecutive vintages. Wines were evaluated through descriptive sensory analysis (DA) by a trained panel, and sensory descriptors were associated with different size geographic scales (zones, departments, and Geographic Indications (GIs)). The application of different sensometric tools allowed us to describe the typicity of wines and discriminate each region, proposing a novel methodology for the comprehensive evaluation of terroir from a sensory viewpoint. The vintage effect was very strong at the departmental and GI level, with aroma, taste and mouthfeel descriptors varying annually. However, certain origin descriptors remained consistent, providing insight into the typicity of Malbec. Considering the extension of the experimental study performed, this methodology provides a proof of concept for understanding both terroir and vintage effects from a sensorial perspective, offering wine producers and consumers a clear message backed by scientific evidence.
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- 2024
14. Targeting prostate tumor low–molecular weight tyrosine phosphatase for oxidation-sensitizing therapy
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Stanford, Stephanie M, Nguyen, Tiffany P, Chang, Joseph, Zhao, Zixuan, Hackman, G Lavender, Santelli, Eugenio, Sanders, Colton M, Katiki, Madhusudhanarao, Dondossola, Eleonora, Brauer, Brooke L, Diaz, Michael A, Zhan, Yuan, Ramsey, Sterling H, Watson, Philip A, Sankaran, Banumathi, Paindelli, Claudia, Parietti, Vanessa, Mikos, Antonios G, Lodi, Alessia, Bagrodia, Aditya, Elliott, Andrew, McKay, Rana R, Murali, Ramachandran, Tiziani, Stefano, Kettenbach, Arminja N, and Bottini, Nunzio
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Urologic Diseases ,Cancer ,Genetics ,Prostate Cancer ,Aging ,2.1 Biological and endogenous factors ,Male ,Humans ,Mice ,Animals ,Molecular Weight ,Prostatic Neoplasms ,Tyrosine ,Protein Tyrosine Phosphatases - Abstract
Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as therapeutic targets. Recent reports suggest low-molecular weight PTP (LMPTP)-encoded by the ACP1 gene-is overexpressed in prostate tumors. We found ACP1 up-regulated in human prostate tumors and ACP1 expression inversely correlated with overall survival. Using CRISPR-Cas9-generated LMPTP knockout C4-2B and MyC-CaP cells, we identified LMPTP as a critical promoter of prostate cancer (PCa) growth and bone metastasis. Through metabolomics, we found that LMPTP promotes PCa cell glutathione synthesis by dephosphorylating glutathione synthetase on inhibitory Tyr270. PCa cells lacking LMPTP showed reduced glutathione, enhanced activation of eukaryotic initiation factor 2-mediated stress response, and enhanced reactive oxygen species after exposure to taxane drugs. LMPTP inhibition slowed primary and bone metastatic prostate tumor growth in mice. These findings reveal a role for LMPTP as a critical promoter of PCa growth and metastasis and validate LMPTP inhibition as a therapeutic strategy for treating PCa through sensitization to oxidative stress.
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- 2024
15. Exploring the relationship between cardiac awareness and balance
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Salvato, Gerardo, Bertolotti, Claudio, Sellitto, Manuela, Fazia, Teresa, Crivelli, Damiano, De Maio, Gabriele, Magnani, Francesca Giulia, Leo, Alessandra, Bianconi, Tatiana, Cortesi, Maria Chiara, Spinelli, Michele, and Bottini, Gabriella
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- 2024
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16. Consensus-driven protocol for transanal irrigation in patients with low anterior resection syndrome and functional constipation
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Martellucci, J., Falletto, E., Ascanelli, S., Bondurri, A., Borin, S., Bottini, C., Caproli, E., Carrera, M., Cestaro, G., Chimisso, L., Clarizia, G., Clementi, I., Cornaglia, S., Costa, S., Gallo, G., Guerci, C., Lambiase, C., Lauretta, A., Luffarelli, P., Neri, M. C., Piccolo, D., Rosati, E., Rossitti, P., Spolini, A., Torchia, G., Valloncini, E., Zattoni, D., Zucchi, E., Biotti, P., Cambareri, A., Coniglio, G., Coppola, A., Nepote Fus, K., Graziani, S., Grilli, M., Grego, A., Guerra, E., Livio, E., Manganini, L., Mazzeo, P., Minonne, A., Mirafiori, M., Negri, G., Palazzolo, V., Di Pasquale, C., and Tantolo, V.
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- 2024
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17. Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants
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Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, and Beheshti, Afshin
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- 2024
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18. To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants
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Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, and Beheshti, Afshin
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- 2024
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19. Identification and characterization of specific motifs in effector proteins of plant parasites using MOnSTER
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Calia, Giulia, Porracciolo, Paola, Chen, Yongpan, Kozlowski, Djampa, Schuler, Hannes, Cestaro, Alessandro, Quentin, Michaël, Favery, Bruno, Danchin, Etienne G. J., and Bottini, Silvia
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- 2024
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20. Evaluation and management of chronic anorectal and pelvic pain syndromes: Italian Society of Colorectal Surgery (SICCR) position statement
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Menconi, C., Marino, F., Bottini, C., La Greca, G., Gozzo, C., Losacco, L., Carlucci, D., Navarra, L., and Martellucci, J.
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- 2024
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21. Space radiation damage rescued by inhibition of key spaceflight associated miRNAs
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McDonald, J. Tyson, Kim, JangKeun, Farmerie, Lily, Johnson, Meghan L., Trovao, Nidia S., Arif, Shehbeel, Siew, Keith, Tsoy, Sergey, Bram, Yaron, Park, Jiwoon, Overbey, Eliah, Ryon, Krista, Haltom, Jeffrey, Singh, Urminder, Enguita, Francisco J., Zaksas, Victoria, Guarnieri, Joseph W., Topper, Michael, Wallace, Douglas C., Meydan, Cem, Baylin, Stephen, Meller, Robert, Muratani, Masafumi, Porterfield, D. Marshall, Kaufman, Brett, Mori, Marcelo A., Walsh, Stephen B., Sigaudo-Roussel, Dominique, Mebarek, Saida, Bottini, Massimo, Marquette, Christophe A., Wurtele, Eve Syrkin, Schwartz, Robert E., Galeano, Diego, Mason, Christopher E., Grabham, Peter, and Beheshti, Afshin
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- 2024
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22. Altered grid-like coding in early blind people
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Sigismondi, Federica, Xu, Yangwen, Silvestri, Mattia, and Bottini, Roberto
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- 2024
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23. Categorical Landau Paradigm for Gapped Phases
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Bhardwaj, Lakshya, Bottini, Lea E., Pajer, Daniel, and Schafer-Nameki, Sakura
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Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Mathematics - Category Theory - Abstract
We propose a unified framework to classify gapped infra-red (IR) phases with categorical symmetries, leading to a generalized, categorical Landau paradigm. This is applicable in any dimension and gives a succinct, comprehensive, and computationally powerful approach to classifying gapped symmetric phases. The key tool is the symmetry topological field theory (SymTFT), which is a one dimension higher TFT with two boundaries, which we choose both to be topological. We illustrate the general idea for (1+1)d gapped phases with categorical symmetries and suggest higher-dimensional extensions., Comment: 4 pages + supplementary material
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- 2023
24. Gapped Phases with Non-Invertible Symmetries: (1+1)d
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Bhardwaj, Lakshya, Bottini, Lea E., Pajer, Daniel, and Schafer-Nameki, Sakura
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High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Mathematics - Category Theory - Abstract
We propose a general framework to characterize gapped infra-red (IR) phases of theories with non-invertible (or categorical) symmetries. In this paper we focus on (1+1)d gapped phases with fusion category symmetries. The approach that we propose uses the Symmetry Topological Field Theory (SymTFT) as a key input: associated to a field theory in d spacetime dimensions, the SymTFT lives in one dimension higher and admits a gapped boundary, which realizes the categorical symmetries. It also admits a second, physical, boundary, which is generically not gapped. Upon interval compactification of the SymTFT by colliding the gapped and physical boundaries, we regain the original theory. In this paper, we realize gapped symmetric phases by choosing the physical boundary to be a gapped boundary condition as well. This set-up provides computational power to determine the number of vacua, the symmetry breaking pattern, and the action of the symmetry on the vacua. The SymTFT also manifestly encodes the order parameters for these gapped phases, thus providing a generalized, categorical Landau paradigm for (1+1)d gapped phases. We find that for non-invertible symmetries the order parameters involve multiplets containing both untwisted and twisted sector local operators, and hence can be interpreted as mixtures of conventional and string order parameters. We also observe that spontaneous breaking of non-invertible symmetries can lead to vacua that are physically distinguishable: unlike the standard symmetries described by groups, non-invertible symmetries can have different actions on different vacua of an irreducible gapped phase. This leads to the presence of relative Euler terms between physically distinct vacua. We also provide a mathematical description of symmetric gapped phases as 2-functors from delooping of fusion category characterizing the symmetry to Euler completion of 2-vector spaces., Comment: 141 pages, v2: corrected an omission in the analysis of TY(Z_N) gapped phases reported by A. Antinucci, references added, v3: some charges corrected in section 7.1, v4,5: referee comments addressed and references added
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- 2023
25. Lectures on Generalized Symmetries
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Bhardwaj, Lakshya, Bottini, Lea E., Fraser-Taliente, Ludovic, Gladden, Liam, Gould, Dewi S. W., Platschorre, Arthur, and Tillim, Hannah
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High Energy Physics - Theory - Abstract
These are a set of lecture notes on generalized global symmetries in quantum field theory. The focus is on invertible symmetries with a few comments regarding non-invertible symmetries. The main topics covered are the basics of higher-form symmetries and their properties including 't Hooft anomalies, gauging and spontaneous symmetry breaking. We also introduce the useful notion of symmetry topological field theories (SymTFTs). Furthermore, an introduction to higher-group symmetries describing mixings of higher-form symmetries is provided. Some advanced topics covered include the encoding of higher-form symmetries in holography and geometric engineering constructions in string theory. Throughout the text, all concepts are consistently illustrated using gauge theories as examples., Comment: 138 pages, added references
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- 2023
26. Non-Invertible Symmetry Webs
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Bhardwaj, Lakshya, Bottini, Lea E., Schafer-Nameki, Sakura, and Tiwari, Apoorv
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High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Mathematics - Category Theory - Abstract
Non-invertible symmetries have by now seen numerous constructions in higher dimensional Quantum Field Theories (QFT). In this paper we provide an in depth study of gauging 0-form symmetries in the presence of non-invertible symmetries. The starting point of our analysis is a theory with $G$ 0-form symmetry, and we propose a description of sequential partial gaugings of sub-symmetries. The gauging implements the theta-symmetry defects of the companion paper [1]. The resulting network of symmetry structures related by this gauging will be called a non-invertible symmetry web. Our formulation makes direct contact with fusion 2-categories, and we uncover numerous interesting structures such as symmetry fractionalization in this categorical setting. The complete symmetry web is derived for several groups $G$, and we propose extensions to higher dimensions. The highlight of this analysis is the complete categorical symmetry web, including non-invertible symmetries, for 3d pure gauge theories with orthogonal gauge groups and its extension to arbitrary dimensions., Comment: 115 pages
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- 2022
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27. Towards a modular construction of OG10
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Bottini, Alessio
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Mathematics - Algebraic Geometry ,14J42, 14F08, 14J60, 53D30 - Abstract
We construct the first example of a stable hyperholomorphic vector bundle of rank five on every hyper-K\"ahler manifold of $\mathrm{K3}^{[2]}$-type whose deformation space is smooth of dimension ten. Its moduli space is birational to a hyper-K\"ahler manifold of type OG10. This provides evidence for the expectation that moduli spaces of sheaves on a hyper-K\"ahler could lead to new examples of hyper-K\"ahler manifolds., Comment: 36 pages. Final version, to appear in Compositio Mathematica
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- 2022
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28. Preference for Prompting Procedures to Address Escape-Maintained Behavior in Autistic Adolescents
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Scheithauer, Mindy C., Bottini, Summer B., and McMahon, Meara X. H.
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- 2024
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29. The therapeutic potential of immunoengineering for systemic autoimmunity
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McBride, David A., Jones, Ryan M., Bottini, Nunzio, and Shah, Nisarg J.
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- 2024
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30. Powder bed monitoring via digital image analysis in additive manufacturing
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Boschetto, A., Bottini, L., and Vatanparast, S.
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- 2024
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31. Self-Reported Adult ADHD Symptoms: Evidence Supporting Cautious Use in an Assessment-Seeking Sample
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Alexandra L. Vizgaitis, Summer Bottini, Craig P. Polizzi, Eileen Barden, and Adam R. Krantweiss
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Objective: Self-report symptom inventories are commonly used in adult ADHD assessment, and research indicates they should be interpreted with caution. This study investigated one self-report symptom inventory for adult ADHD in a clinical sample. Method: Archival data were used to evaluate diagnostic utility of the Conners Adult ADHD Rating Scale--Self-Report: Long Version (CAARS-S:L) in a sample of 122 adults seeking ADHD assessment. Results: Overall, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) estimates for the ADHD Index and other CAARS-S:L scales demonstrated weak accuracy. Anxiety and depression were the most common diagnoses present when a false positive on the ADHD Index was observed. PPV and specificity for the ADHD Index were higher in males compared to females. Conclusion: The CAARS-S:L may be useful for screening purposes in some cases, but should not be the main method used for diagnostic purposes. Clinical implications of findings are discussed.
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- 2023
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32. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis
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McBride, David A, Kerr, Matthew D, Johnson, Wade T, Nguyen, Anders, Zoccheddu, Martina, Yao, Mina, Prideaux, Edward B, Dorn, Nicholas C, Wang, Wei, Svensson, Mattias ND, Bottini, Nunzio, and Shah, Nisarg J
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Biomedical and Clinical Sciences ,Immunology ,Arthritis ,Autoimmune Disease ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Mice ,Animals ,Autoimmune Diseases ,T-Lymphocytes ,Regulatory ,Inflammation ,Tretinoin ,Antirheumatic Agents ,immune engineering ,regulatory T cells ,rheumatoid arthritis - Abstract
Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front-line DMARDs. Here, an immunoregulatory approach based on sustained joint-localized release of all-trans retinoic acid (ATRA), which modulates local immune activation and enhances disease-protective T cells and leads to systemic disease control is reported. ATRA imprints a unique chromatin landscape in T cells, which is associated with an enhancement in the differentiation of naïve T cells into anti-inflammatory regulatory T cells (Treg ) and suppression of Treg destabilization. Sustained release poly-(lactic-co-glycolic) acid (PLGA)-based biodegradable microparticles encapsulating ATRA (PLGA-ATRA MP) are retained in arthritic mouse joints after intra-articular (IA) injection. IA PLGA-ATRA MP enhance migratory Treg which in turn reduce inflammation and modify disease in injected and uninjected joints, a phenotype that is also reproduced by IA injection of Treg . PLGA-ATRA MP reduce proteoglycan loss and bone erosions in the SKG and collagen-induced arthritis mouse models of autoimmune arthritis. Strikingly, systemic disease modulation by PLGA-ATRA MP is not associated with generalized immune suppression. PLGA-ATRA MP have the potential to be developed as a disease modifying agent for autoimmune arthritis.
- Published
- 2023
33. Retention during Task Interspersal versus Varied Instruction
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Bottini, Summer, Gillis Mattson, Jennifer, and Romanczyk, Raymond
- Abstract
Retention (i.e., response maintenance) is rarely the primary variable of interest when examining skill acquisition procedures. Trial presentation type (i.e., acquisition targets only vs. interspersal of previously acquired targets) within discrete-trial training is one procedural component that researchers have hypothesized may affect performance on follow-up retention probes. The present study compared single-task presentation (varied instruction) and task interspersal procedures with regard to retention of a mastered task. We taught four children two skills so that retention of the mastered skill (Skill 1) could be assessed during ongoing instruction of a new skill (Skill 2) using varied instruction versus task interspersal. Findings demonstrated equivalency of varied instruction and task interspersal. Results support that frequent rehearsal of a skill acquisition program without consequences is equivalent to ongoing instruction with consequences. Findings suggest instructors should program follow-up probes of previously mastered content into or between sessions, especially when utilizing single-task trial arrangements that do not incorporate such.
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- 2023
- Full Text
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34. Altered grid-like coding in early blind people during imagined navigation
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Sigismondi, Federica, Xu, Yangwen, Silvestri, Mattia, and Bottini, Roberto
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Neuroscience ,Memory ,Spatial cognition - Abstract
Spatial navigation is supported by the combined activity of brain regions in the human navigation network (HNN) that integrates environmental information across complementary egocentric and allocentric reference frames. Despite humans mainly relying on vision to navigate space, the impact of early visual deprivation on the HNN is mostly unknown. In our experiment sighted and early blind participants were tested in two tasks of imagined navigation while undergoing fMRI. Results show, on the one hand, that both sighted and blind activated regions of the HNN during navigation, with no differences between groups. On the other hand, quadrature filter analysis in the entorhinal cortex, a crucial region for the creation of cognitive maps, revealed an alteration of grid-like coding in early blind individuals, which might be correlated to the adoption of egocentric-like strategies to navigate in space.
- Published
- 2023
35. Non-Invertible Higher-Categorical Symmetries
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Bhardwaj, Lakshya, Bottini, Lea E., Schafer-Nameki, Sakura, and Tiwari, Apoorv
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High Energy Physics - Theory ,Condensed Matter - Strongly Correlated Electrons ,Mathematics - Category Theory - Abstract
We sketch a procedure to capture general non-invertible symmetries of a d-dimensional quantum field theory in the data of a higher-category, which captures the local properties of topological defects associated to the symmetries. We also discuss fusions of topological defects, which involve condensations/gaugings of higher-categorical symmetries localized on the worldvolumes of topological defects. Recently some fusions of topological defects were discussed in the literature where the dimension of topological defects seems to jump under fusion. This is not possible in the standard description of higher-categories. We explain that the dimension-changing fusions are understood as higher-morphisms of the higher-category describing the symmetry. We also discuss how a 0-form sub-symmetry of a higher-categorical symmetry can be gauged and describe the higher-categorical symmetry of the theory obtained after gauging. This provides a procedure for constructing non-invertible higher-categorical symmetries starting from invertible higher-form or higher-group symmetries and gauging a 0-form symmetry. We illustrate this procedure by constructing non-invertible 2-categorical symmetries in 4d gauge theories and non-invertible 3-categorical symmetries in 5d and 6d theories. We check some of the results obtained using our approach against the results obtained using a recently proposed approach based on 't Hooft anomalies., Comment: 104 pages. v2: Removed the distinction between local and global fusion to improve clarity. Added more details on the computation of fusion rules. v3: Minor improvements
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- 2022
- Full Text
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36. Annexin A5 stabilizes matrix vesicle-biomimetic lipid membranes: unravelling a new role of annexins in calcification
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Ferreira, Claudio R., Cruz, Marcos Antônio E., Bolean, Maytê, Andrilli, Luiz Henrique da S., Millan, José Luis, Ramos, Ana Paula, Bottini, Massimo, and Ciancaglini, Pietro
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- 2023
- Full Text
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37. Dualities from dualities: the sequential deconfinement technique
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Bottini, Lea E., Hwang, Chiung, Pasquetti, Sara, and Sacchi, Matteo
- Subjects
High Energy Physics - Theory - Abstract
It is an interesting question whether a given infra-red duality between quantum field theories can be explained in terms of other more elementary dualities. For example recently it has been shown that mirror dualities can be obtained by iterative applications of Seiberg-like dualities. In this paper we continue this line of investigation focusing on theories with tensor matter. In such cases one can apply the idea of deconfinement, which consists of trading the tensor matter for extra gauge nodes by means of a suitable elementary duality. This gives an auxiliary dual frame which can then be manipulated with further dualizations, in an iterative procedure eventually yielding an interesting dual description of the original theory. The sequential deconfinement technique has avatars in different areas of mathematical physics, such as the study of hypergeometric and elliptic hypergeometric integral identities or of $2d$ free field correlators. We discuss various examples in the context $4d$ $\mathcal{N}=1$ supersymmetric theories, which are related to elliptic hypergeometric integrals. These include a new self-duality involving a quiver theory which exhibits a non-trivial global symmetry enhancement to $E_6$., Comment: 61 pages, 15 figures; v2: reference added, published in JHEP
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- 2022
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38. Lipid‐based regulators of immunity
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Johnson, Wade T, Dorn, Nicholas C, Ogbonna, Dora A, Bottini, Nunzio, and Shah, Nisarg J
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Chemical Engineering ,Engineering ,Biomedical Engineering ,2.1 Biological and endogenous factors ,Generic health relevance ,adjuvants ,immunomodulation ,lipids ,polyunsaturated fatty acids ,short-chain fatty acids ,short‐chain fatty acids ,Biomedical engineering ,Chemical engineering - Abstract
Lipids constitute a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. These carbon-rich compounds are primarily sourced from exogenous sources and may be used directly as structural cellular building blocks or as a substrate for generating signaling mediators to regulate cell behavior. In both of these roles, lipids play a key role in both immune activation and suppression, leading to inflammation and resolution, respectively. The simple yet elegant structural properties of lipids encompassing size, hydrophobicity, and molecular weight enable unique biodistribution profiles that facilitate preferential accumulation in target tissues to modulate relevant immune cell subsets. Thus, the structural and functional properties of lipids can be leveraged to generate new materials as pharmacological agents for potently modulating the immune system. Here, we discuss the properties of three classes of lipids: polyunsaturated fatty acids, short-chain fatty acids, and lipid adjuvants. We describe their immunoregulatory functions in modulating disease pathogenesis in preclinical models and in human clinical trials. We conclude with an outlook on harnessing the diverse and potent immune modulating properties of lipids for immunoregulation.
- Published
- 2022
39. 4d $S$-duality wall and $SL(2,\mathbb{Z})$ relations
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Bottini, Lea E., Hwang, Chiung, Pasquetti, Sara, and Sacchi, Matteo
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High Energy Physics - Theory - Abstract
In this paper we present various $4d$ $\mathcal{N}=1$ dualities involving theories obtained by gluing two $E[USp(2N)]$ blocks via the gauging of a common $USp(2N)$ symmetry with the addition of $2L$ fundamental matter chiral fields. For $L=0$ in particular the theory has a quantum deformed moduli space with chiral symmetry breaking and its index takes the form of a delta-function. We interpret it as the Identity wall which identifies the two surviving $USp(2N)$ of each $E[USp(2N)]$ block. All the dualities are derived from iterative applications of the Intriligator--Pouliot duality. This plays for us the role of the fundamental duality, from which we derive all others. We then focus on the $3d$ version of our $4d$ dualities, which now involve the $\mathcal{N}=4$ $T[SU(N)]$ quiver theory that is known to correspond to the $3d$ $S$-wall. We show how these $3d$ dualities correspond to the relations $S^2=-1$, $S^{-1}S=1$ and $T^{-1} S T=S^{-1} T S$ for the $S$ and $T$ generators of $SL(2,\mathbb{Z})$. These observations lead us to conjecture that $E[USp(2N)]$ can also be interpreted as a $4d$ $S$-wall., Comment: 58 pages, 18 figures; v2: references added; v3: version published on JHEP
- Published
- 2021
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40. The Looijenga-Lunts-Verbitsky algebra and Verbitsky's Theorem
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Bottini, Alessio
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Mathematics - Algebraic Geometry ,32J27, 14F25, 14J42, 17B10 - Abstract
In these notes we review some basic facts about the LLV Lie algebra. It is a rational Lie algebra, introduced by Looijenga-Lunts and Verbitsky, acting on the rational cohomology of a compact K\"{a}hler manifold. We study its structure and describe one irreducible component of the rational cohomology in the case of a compact hyperk\"{a}hler manifold., Comment: This review was prepared in the context of the seminar organized by the ERC Synergy Grant HyperK
- Published
- 2021
41. Stable Sheaves on K3 Surfaces via Wall-Crossing
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Bottini, Alessio
- Subjects
Mathematics - Algebraic Geometry ,14D20, 14F05, 14J28, 14J42, 14J60, 18E30 - Abstract
We give a new proof of the following theorem: moduli spaces of stable complexes on a complex projective K3 surface, with primitive Mukai vector and with respect to a generic Bridgeland stability condition, are hyperk\"{a}hler varieties of $\mathrm{K3}^{[n]}$-type of expected dimension. We use derived equivalences, deformations and wall-crossing for Bridgeland stability to reduce to the case of the Hilbert scheme of points., Comment: 37 pages, 2 figures
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- 2021
42. Dimensions of Diversity in Spatial Cognition: Culture, Context, Age, and Ability
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Pitt, Benjamin, Huey, Holly, Jordan, Matthew, Hart, Yuval, Dillon, Moira Rose, Bottini, Roberto, Carstensen, Alexandra, Boni, Isabelle, Piantadosi, Steven, Gibson, Edward, Marghetis, Tyler, Holmes, Kevin J., Star-Lack, Maya, and Chacon, Sandra
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Neuroscience ,Language and thought ,Spatial cognition ,Cross-cultural analysis ,Developmental analysis - Abstract
Throughout the lifespan and across cultures, all human behavior happens in space. By early childhood, people are capable of navigating complex 3D environments, executing sophisticated motor plans, and coordinating action with others. They also use their representations of space to structure a variety of non-spatial concepts, including time, number, similarity, and emotion. How do people perform these cognitive feats? One source of insight comes from studying the diversity of spatial cognition: Although the physical properties of space are invariant, the way people typically conceptualize space varies radically across groups, between individuals, and over development. By studying this variation in spatial cognition, we can better understand the universal set of cognitive and neural mechanisms that underlie it, with implications for the cognitive sciences, education, and design.
- Published
- 2022
43. Preferences for Edible and Electronic Leisure Items: A Systematic Replication
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Scheithauer, Mindy, Martin, Clarissa, and Bottini, Summer
- Abstract
Early studies evaluating the relative preference for leisure compared with edible items suggested that, for most participants (>80%), edible items are more preferred than leisure items. Recent studies suggest more variability in the percentage of participants with this preference. The rationale for this variability could be sampling, setting, availability of items outside of the study, or the items included. As a systematic replication, we conducted preference assessments of leisure, edible, and leisure/edible items combined of 13 children with developmental disabilities. As an inclusion criterion, all participants had an electronic item as the top-preferred leisure item. An edible item ranked first in the combined assessment for 46.2% of participants. This replicates recent findings while accounting for access to edibles outside of the study. These outcomes are important to guide use of preference assessments across reinforcer classes in clinical and school settings.
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- 2022
- Full Text
- View/download PDF
44. Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro
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McBride, David A., Dorn, Nicholas C., Yao, Mina, Johnson, Wade T., Wang, Wei, Bottini, Nunzio, and Shah, Nisarg J.
- Published
- 2023
- Full Text
- View/download PDF
45. Transanal irrigation in functional bowel disorders and LARS: short-term results from an Italian national study
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Falletto, E., Martellucci, J., Rossitti, P., Bondurri, A., Zaffaroni, G., Ascanelli, S., Chimisso, L., Lauretta, A., Mirafiori, M., Clementi, I., Ripetti, V., Lufarelli, P., Cestaro, G., Bottini, C., Bellini, M., Lambiase, C., Di Candido, F., Zattoni, D., Cornaglia, S., Tonello, P., and Zucchi, E.
- Published
- 2023
- Full Text
- View/download PDF
46. Design and fabrication by selective laser melting of a LIDAR reflective unit using metal matrix composite material
- Author
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Boschetto, Alberto, Bottini, Luana, and Macera, Luciano
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- 2023
- Full Text
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47. Space-based Global Maritime Surveillance. Part II: Artificial Intelligence and Data Fusion Techniques
- Author
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Soldi, Giovanni, Gaglione, Domenico, Forti, Nicola, Di Simone, Alessio, Daffinà, Filippo Cristian, Bottini, Gianfausto, Quattrociocchi, Dino, Millefiori, Leonardo M., Braca, Paolo, Carniel, Sandro, Willett, Peter, Iodice, Antonio, Riccio, Daniele, and Farina, Alfonso
- Subjects
Electrical Engineering and Systems Science - Signal Processing - Abstract
Maritime surveillance (MS) is of paramount importance for search and rescue operations, fishery monitoring, pollution control, law enforcement, migration monitoring, and national security policies. Since ground-based radars and automatic identification system (AIS) do not always provide a comprehensive and seamless coverage of the entire maritime domain, the use of space-based sensors is crucial to complement them. We reviewed space-based technologies for MS in the first part of this work, titled "Space-based Global Maritime Surveillance. Part I: Satellite Technologies" [1]. However, future MS systems combining multiple terrestrial and space-based sensors with additional information sources will require dedicated artificial intelligence and data fusion techniques for the processing of raw satellite images and fuse heterogeneous information. The second part of our work focuses on the most promising artificial intelligence and data fusion techniques for MS using space-based sensors., Comment: This paper has been submitted to IEEE Aerospace and Electronic Systems Magazine
- Published
- 2020
- Full Text
- View/download PDF
48. Space-based Global Maritime Surveillance. Part I: Satellite Technologies
- Author
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Soldi, Giovanni, Gaglione, Domenico, Forti, Nicola, Di Simone, Alessio, Daffinà, Filippo Cristian, Bottini, Gianfausto, Quattrociocchi, Dino, Millefiori, Leonardo M., Braca, Paolo, Carniel, Sandro, Willett, Peter, Iodice, Antonio, Riccio, Daniele, and Farina, Alfonso
- Subjects
Electrical Engineering and Systems Science - Signal Processing - Abstract
Maritime surveillance (MS) is crucial for search and rescue operations, fishery monitoring, pollution control, law enforcement, migration monitoring, and national security policies. Since the early days of seafaring, MS has been a critical task for providing security in human coexistence. Several generations of sensors providing detailed maritime information have become available for large offshore areas in real time: maritime radar sensors in the 1950s and the automatic identification system (AIS) in the 1990s among them. However, ground-based maritime radars and AIS data do not always provide a comprehensive and seamless coverage of the entire maritime space. Therefore, the exploitation of space-based sensor technologies installed on satellites orbiting around the Earth, such as satellite AIS data, synthetic aperture radar, optical sensors, and global navigation satellite systems reflectometry, becomes crucial for MS and to complement the existing terrestrial technologies. In the first part of this work, we provide an overview of the main available space-based sensors technologies and present the advantages and limitations of each technology in the scope of MS. The second part, related to artificial intelligence, signal processing and data fusion techniques, is provided in a companion paper, titled: "Space-based Global Maritime Surveillance. Part II: Artificial Intelligence and Data Fusion Techniques" [1]., Comment: This paper has been submitted to IEEE Aerospace and Electronic Systems Magazine
- Published
- 2020
- Full Text
- View/download PDF
49. How to Train your DNN: The Network Operator Edition
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Chang, Michael Alan, Bottini, Domenic, Jian, Lisa, Kumar, Pranay, Panda, Aurojit, and Shenker, Scott
- Subjects
Computer Science - Networking and Internet Architecture ,Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Machine Learning - Abstract
Deep Neural Nets have hit quite a crest, But physical networks are where they must rest, And here we put them all to the test, To see which network optimization is best.
- Published
- 2020
50. Mental search of concepts is supported by egocentric vector representations and restructured grid maps
- Author
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Viganò, Simone, Bayramova, Rena, Doeller, Christian F., and Bottini, Roberto
- Published
- 2023
- Full Text
- View/download PDF
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