22 results on '"Boudjoghra, Myriam"'
Search Results
2. Immunoglobulin Gene Mutational Status Assessment by Next Generation Sequencing in Chronic Lymphocytic Leukemia
- Author
-
Langlois de Septenville, Anne, Boudjoghra, Myriam, Bravetti, Clotilde, Armand, Marine, Salson, Mikaël, Giraud, Mathieu, Davi, Frederic, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Bioinformatics and Sequence Analysis (BONSAI), Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Anton W. Langerak, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Somatic hypermutation analysis ,Genes, Immunoglobulin ,Mutational status ,High-Throughput Nucleotide Sequencing ,Immunoglobulins ,Receptors, Antigen, B-Cell ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Immunoglobulin genes ,Leukemia, Lymphocytic, Chronic, B-Cell ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,hemic and lymphatic diseases ,Next generation sequencing ,Humans ,Chronic lymphocytic leukemia ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,Research Article - Abstract
B cell receptor (BcR) immunoglobulins (IG) display a tremendous diversity due to complex DNA rearrangements, the V(D)J recombination, further enhanced by the somatic hypermutation process. In chronic lymphocytic leukemia (CLL), the mutational load of the clonal BcR IG expressed by the leukemic cells constitutes an important prognostic and predictive biomarker. Here, we provide a reliable methodology capable of determining the mutational status of IG genes in CLL using high-throughput sequencing, starting from leukemic cell DNA or RNA.
- Published
- 2022
3. MZ lymphoproliferations: shared and unique characteristics
- Author
-
Xochelli, Aliki, Bikos, Vasilis, Polychronidou, Eleftheria, Galigalidou, Chrysi, Agathangelidis, Andreas, Charlotte, Frédéric, Moschonas, Panagiotis, Davis, Zadie, Colombo, Monica, Roumelioti, Maria, Sutton, Lesley-Ann, Groenen, Patricia, van den Brand, Michiel, Boudjoghra, Myriam, Algara, Patricia, Traverse-Glehen, Alexandra, Ferrer, Ana, Stalika, Evangelia, Karypidou, Maria, Kanellis, George, Kalpadakis, Christina, Mollejo, Manuella, Pangalis, Gerasimos, Vlamos, Panayiotis, Amini, Rose-Marie, Pospisilova, Sarka, Gonzalez, David, Ponzoni, Maurilio, Anagnostopoulos, Achilles, Giudicelli, Véronique, Lefranc, Marie-Paule, Espinet, Blanca, Panagiotidis, Panagiotis, Piris, Miguel Angel, Du, Ming-Qing, Rosenquist, Richard, Papadaki, Theodora, Belessi, Chrysoula, Ferrarini, Manlio, Oscier, David, Tzovaras, Dimitrios, Ghia, Paolo, Davi, Frederic, Hadzidimitriou, Anastasia, Stamatopoulos, Kostas, Apollo - University of Cambridge Repository, Institute of Applied Biosciences, CERTH, Thessaloniki, Greece., Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Central European Institute of Technology [Brno] (CEITEC MU), Brno University of Technology [Brno] (BUT), Information Technologies Institute, CERTH, Thessaloniki, Greece., Department of Informatics, Ionian University, Corfu, Greece, Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milan, Italy., Service d'anatomie et cytologie pathologiques [CHU Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de pathologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Information Technologies Institute, CERTH, Thessaloniki, Greece, Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK., Molecular Pathology, Ospedale Policlinico SanMartino, Genoa, Italy., First Department of Propaedeutic Medicine, University of Athens, Athens, Greece, Uppsala Universitet [Uppsala], Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'Hématologie Biologique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hospital Virgen de la Salud, Toledo, Spain, Department of Pathology and Hematology, Hospices Civils de Lyon (HCL), Laboratori de Citologia Hematològica i Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain, Centre for Research and Technology Hellas (CERTH), Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece, Hematopathology Department, Evangelismos Hospital, Athens, Greece., Department of Haematology, University of Crete, Heraklion, Greece., Department of Haematology, Athens Medical Center, Athens, Greece, Department of Informatics [Ionian University], Ionian University [Corfu], Department of Informatics, Ionian University, Corfu, Greece., Department of Genetics and Pathology, Uppsala University Hospital, CEITEC-Central European Institute of Technology, MasarykBrno, Czech Republic., Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele H Scientific Institute, Pathology Unit, San Raffaele Scientific Institute, Milan, Italy, Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoris de Citologia Hematológica/Citogenética Molecular. Servei de Patologia, GRETNHE, IMIM-Hospital del Mar, Laboratori de Citologia Hematològica i Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain., Pathology Department, IIS 'Fundacion Jimenez Diaz', Madrid, Spain, Pathology, University of Cambridge [UK] (CAM), Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK, Hematology Department, Nikea General Hospital, Piraeus, Greece, Direzione Scientifica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino-IST, Genoa, Italy., Informatics & Telematics Institute (ITI), CERTH, Università Vita e Salute, San Raffaele, Milano, Italy, Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milan, Italy, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute of Applied Biosciences, Centre for Research and Technology-Hellas, Thessaloniki, Greece, Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden, Xochelli, Aliki, Bikos, Vasili, Polychronidou, Eleftheria, Galigalidou, Chrysi, Agathangelidis, Andrea, Charlotte, Frédéric, Moschonas, Panagioti, Davis, Zadie, Colombo, Monica, Roumelioti, Maria, Sutton, Lesley-Ann, Groenen, Patricia, van den Brand, Michiel, Boudjoghra, Myriam, Algara, Patricia, Traverse-Glehen, Alexandra, Ferrer, Ana, Stalika, Evangelia, Karypidou, Maria, Kanellis, George, Kalpadakis, Christina, Mollejo, Manuella, Pangalis, Gerasimo, Vlamos, Panayioti, Amini, Rose-Marie, Pospisilova, Sarka, Gonzalez, David, Ponzoni, Maurilio, Anagnostopoulos, Achille, Giudicelli, Véronique, Lefranc, Marie-Paule, Espinet, Blanca, Panagiotidis, Panagioti, Piris, Miguel Angel, Du, Ming-Qing, Rosenquist, Richard, Papadaki, Theodora, Belessi, Chrysoula, Ferrarini, Manlio, Oscier, David, Tzovaras, Dimitrio, Ghia, Paolo, Davi, Frederic, Hadzidimitriou, Anastasia, and Stamatopoulos, Kostas
- Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics ,Genes, Immunoglobulin ,Genes, Immunoglobulin Heavy Chain ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,[SDV]Life Sciences [q-bio] ,Immunoglobulin Variable Region ,Receptors, Antigen, B-Cell ,Lymphoma, B-Cell, Marginal Zone ,Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] ,Complementarity Determining Regions ,marginal zone lymphoma ,immunoglobulin gene ,antigen ,ontogeny ,Marginal zone lymphoma ,Mutation ,Tumor Microenvironment ,Humans ,Gene Rearrangement, B-Lymphocyte - Abstract
Contains fulltext : 203155.pdf (Publisher’s version ) (Closed access) The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- Published
- 2019
4. Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
- Author
-
Tsakou, Eugenia, Agathagelidis, Andreas, Boudjoghra, Myriam, Raff, Thorsten, Dagklis, Antonis, Chatzouli, Maria, Smilevska, Tatjana, Bourikas, George, Merle-Beral, Helene, Manioudaki-Kavallieratou, Eleni, Anagnostopoulos, Achilles, Brüggemann, Monika, Davi, Frederic, Stamatopoulos, Kostas, and Belessi, Chrysoula
- Published
- 2012
- Full Text
- View/download PDF
5. Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma
- Author
-
Mahendra, Ankit, Gangadharan, Bagirath, André, Sébastien, Boudjoghra, Myriam, Davi, Frédéric, Lecerf, Maxime, Planchais, Cyril, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien, and Dimitrov, Jordan D.
- Published
- 2014
- Full Text
- View/download PDF
6. Primary vitreoretinal lymphomas display a remarkably restricted immunoglobulin gene repertoire
- Author
-
Belhouachi, Nabila, primary, Xochelli, Aliki, primary, Boudjoghra, Myriam, primary, Lesty, Claude, primary, Cassoux, Nathalie, primary, Fardeau, Christine, primary, Tran, Thi Ha Chau, primary, Choquet, Sylvain, primary, Sarker, Bishnu, primary, Houillier, Caroline, primary, Alentorn, Agusti, primary, LeHoang, Phuc, primary, Soussain, Carole, primary, Touitou, Valerie, primary, Merle-Beral, Helene, primary, Hoang-Xuan, Khe, primary, Bodaghi, Bahram, primary, Stamatopoulos, Kostas, primary, and Davi, Frederic, primary
- Published
- 2020
- Full Text
- View/download PDF
7. Disease‐biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
- Author
-
Xochelli, Aliki, primary, Bikos, Vasilis, additional, Polychronidou, Eleftheria, additional, Galigalidou, Chrysi, additional, Agathangelidis, Andreas, additional, Charlotte, Frédéric, additional, Moschonas, Panagiotis, additional, Davis, Zadie, additional, Colombo, Monica, additional, Roumelioti, Maria, additional, Sutton, Lesley‐Ann, additional, Groenen, Patricia, additional, van den Brand, Michiel, additional, Boudjoghra, Myriam, additional, Algara, Patricia, additional, Traverse‐Glehen, Alexandra, additional, Ferrer, Ana, additional, Stalika, Evangelia, additional, Karypidou, Maria, additional, Kanellis, George, additional, Kalpadakis, Christina, additional, Mollejo, Manuella, additional, Pangalis, Gerasimos, additional, Vlamos, Panayiotis, additional, Amini, Rose‐Marie, additional, Pospisilova, Sarka, additional, Gonzalez, David, additional, Ponzoni, Maurilio, additional, Anagnostopoulos, Achilles, additional, Giudicelli, Véronique, additional, Lefranc, Marie‐Paule, additional, Espinet, Blanca, additional, Panagiotidis, Panagiotis, additional, Piris, Miguel Angel, additional, Du, Ming‐Qing, additional, Rosenquist, Richard, additional, Papadaki, Theodora, additional, Belessi, Chrysoula, additional, Ferrarini, Manlio, additional, Oscier, David, additional, Tzovaras, Dimitrios, additional, Ghia, Paolo, additional, Davi, Frederic, additional, Hadzidimitriou, Anastasia, additional, and Stamatopoulos, Kostas, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Erratum to: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
- Author
-
Tsakou, Eugenia, Agathagelidis, Andreas, Boudjoghra, Myriam, Raff, Thorsten, Dagklis, Antonis, Chatzouli, Maria, Smilevska, Tatjana, Bourikas, George, Merle-Beral, Helene, Manioudaki-Kavallieratou, Eleni, Anagnostopoulos, Achilles, Brüggemann, Monika, Davi, Frederic, Stamatopoulos, Kostas, and Belessi, Chrysoula
- Published
- 2013
- Full Text
- View/download PDF
9. Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites
- Author
-
Agathangelidis, Andreas Hadzidimitriou, Anastasia Minga, Eva and Sutton, Lesley-Ann Polychronidou, Eleftheria Shanafelt, Tait D. and Davis, Zadie Yan, Xiao-Jie Plevova, Karla Boudjoghra, Myriam Navarro, Alba Rossi, Davide Pedersen, Lone Bredo and Bikos, Vasilis Baliakas, Panagiotis Scarfo, Lydia Mattsson, Mattias Xochelli, Aliki di Celle, Paola Francia and Giannopoulos, Krzysztof Vanura, Katrina Evers, Ludo and Veronese, Silvio Facco, Monica Moschonas, Panagiotis Bystry, Vojtech Karan-Djurasevic, Teodora Roumelioti, Maria and Pavlovic, Sonja Mansouri, Larry Chu, Charles Stalika, Evangelia Giudicelli, Veronique Panagiotidis, Panagiotis and Sudarikov, Andrey Anagnostopoulos, Achilles Trentin, Livio and Catherwood, Mark Montillo, Marco Stavroyianni, Niki Gaidano, Gianluca Campo, Elias Niemann, Carsten Utoft Langerak, Anton W. Pospisilova, Sarka Lefranc, Marie-Paule Jaeger, Ulrich and Kater, Arnon Pott, Christiane Chiorazzi, Nicholas and Oscier, David Jelinek, Diane F. Stilgenbauer, Stephan and Hallek, Michael Tzovaras, Dimitrios Darzentas, Nikos and Belessi, Chrysoula Davi, Frederic Rosenquist, Richard Ghia, Paolo Stamatopoulos, Kostas
- Published
- 2016
10. Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites
- Author
-
Agathangelidis, Andreas, primary, Hadzidimitriou, Anastasia, additional, Minga, Eva, additional, Sutton, Lesley-Ann, additional, Polychronidou, Eleftheria, additional, Shanafelt, Tait D., additional, Davis, Zadie, additional, Yan, Xiao-Jie, additional, Plevova, Karla, additional, Boudjoghra, Myriam, additional, Navarro, Alba, additional, Rossi, Davide, additional, Bredo Pedersen, Lone, additional, Bikos, Vasilis, additional, Baliakas, Panagiotis, additional, Scarfò, Lydia, additional, Mattsson, Mattias, additional, Xochelli, Aliki, additional, di Celle, Paola Francia, additional, Giannopoulos, Krzysztof, additional, Vanura, Katrina, additional, Evers, Ludo, additional, Veronese, Silvio, additional, Facco, Monica, additional, Moschonas, Panagiotis, additional, Bystry, Vojtech, additional, Karan-Djurasevic, Teodora, additional, Roumelioti, Maria, additional, Pavlovic, Sonja, additional, Mansouri, Larry, additional, Chu, Charles, additional, Stalika, Evangelia, additional, Giudicelli, Veronique, additional, Panagiotidis, Panagiotis, additional, Sudarikov, Andrey, additional, Anagnostopoulos, Achilles, additional, Trentin, Livio, additional, Catherwood, Mark, additional, Montillo, Marco, additional, Stavroyianni, Niki, additional, Gaidano, Gianluca, additional, Campo, Elias, additional, Niemann, Carsten Utoft, additional, Langerak, Anton W., additional, Pospisilova, Sarka, additional, Lefranc, Marie-Paule, additional, Jaeger, Ulrich, additional, Kater, Arnon, additional, Pott, Christiane, additional, Chiorazzi, Nicholas, additional, Oscier, David, additional, Jelinek, Diane F., additional, Stilgenbauer, Stephan, additional, Hallek, Michael, additional, Tzovaras, Dimitrios, additional, Darzentas, Nikos, additional, Belessi, Chrysoula, additional, Davi, Frederic, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional
- Published
- 2016
- Full Text
- View/download PDF
11. Auto-Immune Origin of B Cells from HCV-Associated Lymphoma
- Author
-
Armand, Marine, primary, Boudjoghra, Myriam, additional, Xochelli, Aliki, additional, Canioni, Danielle, additional, Le Garff Tavernier, Magali, additional, Colombo, Monica, additional, Rabiega, Pascaline, additional, Molina, Thierry, additional, Charlotte, Frederic, additional, Michot, Jean-Marie, additional, Lesty, Claude, additional, Carrat, Fabrice, additional, Ferrarini, Manlio, additional, Stamatopoulos, Kostas, additional, Besson, Caroline, additional, Hermine, Olivier, additional, and Davi, Frederic, additional
- Published
- 2015
- Full Text
- View/download PDF
12. Unique Versus Common: Disease-Biased Immunoglobulin Gene Repertoires Along with Public Antigen Receptor Stereotypes in Marginal Zone B-Cell Lymphoproliferations
- Author
-
Xochelli, Aliki, primary, Bikos, Vasilis, additional, Polychronidou, Eleftheria, additional, Agathangelidis, Andreas, additional, Charlotte, Frederic, additional, Moschonas, Panagiotis, additional, Davis, Zadie, additional, Colombo, Monica, additional, Roumelioti, Maria, additional, Sutton, Lesley-Ann, additional, Groenen, Patricia, additional, Boudjoghra, Myriam, additional, Algara, Patricia, additional, Traverse-Glehen, Alexandra, additional, Ferrer, Ana, additional, Stalika, Evangelia, additional, Karypidou, Maria, additional, Kanellis, George, additional, Kalpadakis, Christina, additional, Mollejo, Manuella, additional, Pangalis, Gerasimos, additional, Vlamos, Panayiotis, additional, Amini, Rose-Marie, additional, Pospisilova, Sarka, additional, Gonzalez, David, additional, Ponzoni, Maurilio, additional, Anagnostopoulos, Achilles, additional, Giudicelli, Veronique, additional, Lefranc, Marie-Paule, additional, Espinet, Blanca, additional, Panagiotidis, Panagiotis, additional, Piris, Miguel Angel, additional, Du, Ming, additional, Rosenquist, Richard, additional, Papadaki, Theodora, additional, Belessi, Chrysoula, additional, Ferrarini, Manlio, additional, Oscier, David, additional, Tzovaras, Dimitrios, additional, Ghia, Paolo, additional, Davi, Frederic, additional, Hadzidimitriou, Anastasia, additional, and Stamatopoulos, Kostas, additional
- Published
- 2015
- Full Text
- View/download PDF
13. MOESM1 of Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
- Author
-
Tsakou, Eugenia, Agathagelidis, Andreas, Boudjoghra, Myriam, Raff, Thorsten, Dagklis, Antonis, Chatzouli, Maria, Smilevska, Tatjana, Bourikas, George, Merle-Beral, Helene, Manioudaki-Kavallieratou, Eleni, Achilles Anagnostopoulos, BrĂźggemann, Monika, Davi, Frederic, Stamatopoulos, Kostas, and Belessi, Chrysoula
- Abstract
Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
- Published
- 2011
- Full Text
- View/download PDF
14. Clinical Impact of Stereotyped Antigen Receptors in Chronic Lymphocytic Leukemia
- Author
-
Baliakas, Panagiotis, primary, Hadzidimitriou, Anastasia, additional, Sutton, Lesley-Ann, additional, Minga, Evangelia, additional, Agathangelidis, Andreas, additional, Tsanousa, Athina, additional, Scarfo, Lydia, additional, Davis, Zadie, additional, Yan, Joy, additional, Shanafelt, Tait D., additional, Plevova, Karla, additional, Sandberg, Yorick, additional, Vojdeman, Fie Juhl, additional, Boudjoghra, Myriam, additional, Tzenou, Tatiana, additional, Chatzouli, Maria, additional, Chu, Charles C., additional, Veronese, Silvio, additional, Gardiner, Anne Catherine, additional, Mansouri, Larry, additional, Smedby, Karin E, additional, Pedersen, Lone, additional, Moreno, Denis, additional, van Lom, Kirsten, additional, Giudicelli, Veronique, additional, Francova, Hana, additional, Nguyen-Khac, Florence, additional, Panagiotidis, Panagiotis, additional, Juliusson, Gunnar, additional, Angelis, Lefteris, additional, Anagnostopoulos, Achilles, additional, Lefranc, Marie-Paule, additional, Facco, Monica, additional, Trentin, Livio, additional, Catherwood, Mark, additional, Montillo, Marco, additional, Geisler, Christian H, additional, Langerak, Anton W, additional, Pospisilova, Sarka, additional, Chiorazzi, Nicholas, additional, Oscier, David, additional, Jelinek, Diane F., additional, Darzentas, Nikos, additional, Belessi, Chrysoula, additional, Davi, Frederic, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional
- Published
- 2014
- Full Text
- View/download PDF
15. Primary Intraocular Lymphomas Display A Remarkably Biased Immunoglobulin Heavy Chain Gene Repertoire and Precisely Targeted Somatic Hypermutation Suggesting Antigenic Selection of the Neoplastic Cells
- Author
-
Belhouachi, Nabila, primary, Stalika, Evangelia, additional, Bodaghi, Bahram, additional, Boudjoghra, Myriam, additional, Cassoux, Nathalie, additional, Fardeau, Christine, additional, Baudet, Sylvie, additional, Hoang, Phuc Le, additional, Merle-Beral, Helene, additional, Stamatopoulos, Kostas, additional, and Davi, Frederic, additional
- Published
- 2011
- Full Text
- View/download PDF
16. Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
- Author
-
Tsakou, Eugenia, primary, Agathagelidis, Andreas, additional, Boudjoghra, Myriam, additional, Raff, Thorsten, additional, Dagklis, Antonis, additional, Chatzouli, Maria, additional, Smilevska, Tatjana, additional, Bourikas, George, additional, Merle-Beral, Helene, additional, Manioudaki-Kavallieratou, Eleni, additional, Anagnostopoulos, Achilles, additional, Brüggemann, Monika, additional, Davi, Frederic, additional, Stamatopoulos, Kostas, additional, and Belessi, Chrysoula, additional
- Published
- 2011
- Full Text
- View/download PDF
17. Insight Into HCDR3 Restrictions in CLL by Analysis of Incomplete IGHD-IGHJ Rearrangements: Further Evidence that Somatic Selection Shapes the Expressed CLL Immunoglobulin Repertoire.
- Author
-
Tsakou, Eugenia, primary, Agathagelidis, Andreas, additional, Boudjoghra, Myriam, additional, Raff, Thorsten, additional, Dagklis, Antonis, additional, Bourikas, Georgios, additional, Merle-Beral, Helene, additional, Anagnostopoulos, Achilles, additional, Laoutaris, Nikolaos, additional, Bruggemann, Monika, additional, Davi, Frederic, additional, Stamatopoulos, Kostas, additional, and Belessi, Chrysoula, additional
- Published
- 2009
- Full Text
- View/download PDF
18. ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.
- Author
-
Bystry, Vojtech, Reigl, Tomas, Krejci, Adam, Demko, Martin, Hanakova, Barbora, Grioni, Andrea, Knecht, Henrik, Schlitt, Max, Dreger, Peter, Sellner, Leopold, Herrmann, Dietrich, Pingeon, Marine, Boudjoghra, Myriam, Rijntjes, Jos, Pott, Christiane, Langerak, Anton W., Groenen, Patricia J. T. A., Davi, Frederic, Brüggemann, Monika, and Darzentas, Nikos
- Subjects
IMMUNOGLOBULINS ,T cell receptors ,NUCLEOTIDE sequencing ,WEB-based user interfaces ,IMMUNOGENETICS ,STOCHASTIC processes - Abstract
Motivation: The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results: We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
19. Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
- Author
-
Xochelli, Aliki, Bikos, Vasilis, Polychronidou, Eleftheria, Galigalidou, Chrysi, Agathangelidis, Andreas, Charlotte, Frédéric, Moschonas, Panagiotis, Davis, Zadie, Colombo, Monica, Roumelioti, Maria, Sutton, Lesley-Ann, Groenen, Patricia, Van Den Brand, Michiel, Boudjoghra, Myriam, Algara, Patricia, Traverse-Glehen, Alexandra, Ferrer, Ana, Stalika, Evangelia, Karypidou, Maria, Kanellis, George, Kalpadakis, Christina, Mollejo, Manuella, Pangalis, Gerasimos, Vlamos, Panayiotis, Amini, Rose-Marie, Pospisilova, Sarka, Gonzalez, David, Ponzoni, Maurilio, Anagnostopoulos, Achilles, Giudicelli, Véronique, Lefranc, Marie-Paule, Espinet, Blanca, Panagiotidis, Panagiotis, Piris, Miguel Angel, Du, Ming-Qing, Rosenquist, Richard, Papadaki, Theodora, Belessi, Chrysoula, Ferrarini, Manlio, Oscier, David, Tzovaras, Dimitrios, Ghia, Paolo, Davi, Frederic, Hadzidimitriou, Anastasia, and Stamatopoulos, Kostas
- Subjects
immunoglobulin gene ,antigen ,ontogeny ,Marginal zone lymphoma ,3. Good health - Abstract
The B cell receptor immunoglobulin (BcR IG) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n=488) i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL) as well as provisional entities (n=76) according to the World Health Organization classification. The most striking IG gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different IG gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ IG sequence dataset with a large dataset of IG sequences (MZ-related or not; n=65,837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia but also rheumatoid factors and non-malignant spleen MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms, may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments.
20. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors
- Author
-
Marta Larrayoz, Panagiotis Panagiotidis, Theodoros Moysiadis, Evangelia Stalika, Kostas Stamatopoulos, Alba Navarro, Šárka Pospíšilová, Xiao-Jie Yan, Chrysoula Belessi, Jitka Malčíková, Florence Nguyen-Khac, Frederic Davi, Richard Rosenquist, Lesley-Ann Sutton, Lone Bredo Pedersen, Nicholas Chiorazzi, Karla Plevová, Gianluca Gaidano, Panagiotis Baliakas, Lydia Scarfò, Emma Young, Andreas Agathangelidis, Paolo Ghia, Anton W. Langerak, Carsten Utoft Niemann, Davide Rossi, Jonathan C. Strefford, Elias Campo, Alice F. Muggen, Myriam Boudjoghra, Larry Mansouri, Jana Kminkova, Anastasia Hadzidimitriou, Zadie Davis, David Oscier, Sutton, Lesley Ann, Young, Emma, Baliakas, Panagioti, Hadzidimitriou, Anastasia, Moysiadis, Theodoro, Plevova, Karla, Rossi, Davide, Kminkova, Jana, Stalika, Evangelia, Pedersen, Lone Bredo, Malcikova, Jitka, Agathangelidis, Andrea, Davis, Zadie, Mansouri, Larry, Scarfò, Lydia, Boudjoghra, Myriam, Navarro, Alba, Muggen, Alice F., Yan, Xiao Jie, Nguyen Khac, Florence, Larrayoz, Marta, Panagiotidis, Panagioti, Chiorazzi, Nichola, Niemann, Carsten Utoft, Belessi, Chrysoula, Campo, Elia, Strefford, Jonathan C., Langerak, Anton W., Oscier, David, Gaidano, Gianluca, Pospisilova, Sarka, Davi, Frederic, Ghia, PAOLO PROSPERO, Stamatopoulos, Kosta, Rosenquist, Richard, Immunology, Uppsala Universitet [Uppsala], Centre for Research and Technology Hellas (CERTH), Masaryk University [Brno] (MUNI), Università degli Studi del Piemonte Orientale - Amedeo Avogadro (UPO), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Università Vita e Salute, San Raffaele, Milano, Italy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Royal Bournemouth Hospital, Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'Hématologie clinique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Erasmus University Medical Center [Rotterdam] (Erasmus MC), The Feinstein Institute for Medical Research, University of Southampton, National and Kapodistrian University of Athens (NKUA), Hematology Department, Nikea General Hospital, Piraeus, Greece, George Papanicolau Hospital, Universitat de Barcelona, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Male ,Chronic lymphocytic leukemia ,Immunoglobulin Variable Region ,Receptors, Antigen, B-Cell ,Somatic hypermutation ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Gene mutation ,Biology ,medicine.disease_cause ,Polymorphism, Single Nucleotide ,Somatic evolution in cancer ,03 medical and health sciences ,Genètica mèdica ,0302 clinical medicine ,Gene Frequency ,Biomarkers, Tumor ,medicine ,Humans ,Leucèmia limfocítica crònica ,Gene Rearrangement, B-Lymphocyte ,Genetics ,Mutation ,Genes, Immunoglobulin ,Mutació (Biologia) ,Medical genetics ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Articles ,Gene rearrangement ,Hematology ,Mutation (Biology) ,Prognosis ,medicine.disease ,Complementarity Determining Regions ,Leukemia, Lymphocytic, Chronic, B-Cell ,3. Good health ,Leukemia ,030220 oncology & carcinogenesis ,Cytogenetic Analysis ,Immunoglobulin Joining Region ,Immunoglobulin heavy chain ,Female ,Immunoglobulin Heavy Chains ,030215 immunology - Abstract
on behalf of ERIC, the European Research Initiative on CLL; International audience; We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobu-lins in the largest cohort (n=565) studied for this purpose. By combining data on recurrent gene mutations (BIRC3, MYD88, NOTCH1, SF3B1 and TP53) and cytogenetic aberrations, we reveal a subset-biased acquisition of gene mutations. More specifically, the frequency of NOTCH1 mutations was found to be enriched in subsets expressing unmutated immunoglobu-lin genes, i.e. #1, #6, #8 and #59 (22-34%), often in association with trisomy 12, and was significantly different (P
- Published
- 2016
21. Immunoglobulin Gene Mutational Status Assessment by Next Generation Sequencing in Chronic Lymphocytic Leukemia.
- Author
-
Langlois de Septenville A, Boudjoghra M, Bravetti C, Armand M, Salson M, Giraud M, and Davi F
- Subjects
- Genes, Immunoglobulin, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulins genetics, Receptors, Antigen, B-Cell genetics, Leukemia, Lymphocytic, Chronic, B-Cell genetics
- Abstract
B cell receptor (BcR) immunoglobulins (IG) display a tremendous diversity due to complex DNA rearrangements, the V(D)J recombination, further enhanced by the somatic hypermutation process. In chronic lymphocytic leukemia (CLL), the mutational load of the clonal BcR IG expressed by the leukemic cells constitutes an important prognostic and predictive biomarker. Here, we provide a reliable methodology capable of determining the mutational status of IG genes in CLL using high-throughput sequencing, starting from leukemic cell DNA or RNA., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
22. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.
- Author
-
Sutton LA, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri L, Scarfò L, Boudjoghra M, Navarro A, Muggen AF, Yan XJ, Nguyen-Khac F, Larrayoz M, Panagiotidis P, Chiorazzi N, Niemann CU, Belessi C, Campo E, Strefford JC, Langerak AW, Oscier D, Gaidano G, Pospisilova S, Davi F, Ghia P, Stamatopoulos K, and Rosenquist R
- Subjects
- Complementarity Determining Regions genetics, Cytogenetic Analysis, Female, Gene Frequency, Gene Rearrangement, B-Lymphocyte, Genes, Immunoglobulin, Humans, Immunoglobulin Heavy Chains genetics, Immunoglobulin Joining Region genetics, Immunoglobulin Variable Region genetics, Leukemia, Lymphocytic, Chronic, B-Cell mortality, Male, Polymorphism, Single Nucleotide, Prognosis, Biomarkers, Tumor, Leukemia, Lymphocytic, Chronic, B-Cell genetics, Leukemia, Lymphocytic, Chronic, B-Cell metabolism, Mutation, Receptors, Antigen, B-Cell genetics, Receptors, Antigen, B-Cell metabolism
- Abstract
We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobulins in the largest cohort (n=565) studied for this purpose. By combining data on recurrent gene mutations (BIRC3, MYD88, NOTCH1, SF3B1 and TP53) and cytogenetic aberrations, we reveal a subset-biased acquisition of gene mutations. More specifically, the frequency of NOTCH1 mutations was found to be enriched in subsets expressing unmutated immunoglobulin genes, i.e. #1, #6, #8 and #59 (22-34%), often in association with trisomy 12, and was significantly different (P<0.001) to the frequency observed in subset #2 (4%, aggressive disease, variable somatic hypermutation status) and subset #4 (1%, indolent disease, mutated immunoglobulin genes). Interestingly, subsets harboring a high frequency of NOTCH1 mutations were found to carry few (if any) SF3B1 mutations. This starkly contrasts with subsets #2 and #3 where, despite their immunogenetic differences, SF3B1 mutations occurred in 45% and 46% of cases, respectively. In addition, mutations within TP53, whilst enriched in subset #1 (16%), were rare in subsets #2 and #8 (both 2%), despite all being clinically aggressive. All subsets were negative for MYD88 mutations, whereas BIRC3 mutations were infrequent. Collectively, this striking bias and skewed distribution of mutations and cytogenetic aberrations within specific chronic lymphocytic leukemia subsets implies that the mechanisms underlying clinical aggressiveness are not uniform, but rather support the existence of distinct genetic pathways of clonal evolution governed by a particular stereotyped B-cell receptor selecting a certain molecular lesion(s)., (Copyright© Ferrata Storti Foundation.)
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.