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31 results on '"Bouhaidar, Ralph"'

3. Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome: Population-Based Study

Author

Samarasekera, Neshika, Fonville, Arthur, Lerpiniere, Christine, Farrall, Andrew J., Wardlaw, Joanna M., White, Philip M., Smith, Colin, Al-Shahi Salman, Rustam, Addison, Anne, Ahmad, Kate, Alhadad, Syed, Andrews, Peter, Bisset, Elaine, Bodkin, Peter, Bouhaidar, Ralph, Brennan, Paul, Campbell, Brian, Chandran, Siddharthan, Cook, Helen, Davenport, Richard, Dennis, Martin, Derry, Chris, Dodds, Katrina, Doubal, Fergus, Duncan, Susan, Elder, Andrew, Fitzpatrick, Mike, Foley, Peter, Fouyas, Ioannis, Ghosh, Sudipto, Gibson, Rod, Gordon, Claire, Grant, Robin, Hewett, Russell, Hughes, Fiona, Hughes, Mark, Hunt, David, Hunter, Neil, Ironside, James, Liaquat, Imran, Josephson, Colin, Kamat, Anant, Kealley, Susan, Keir, Sarah, Kerr, Gillian, Kerrigan, Simon, Keston, Peter, King, Matthew, Knight, Richard, Macdonald, Elizabeth, Mackay, Graham, Macleod, Donald, Macleod, Malcolm, Maguire, Conor, Makin, Steven, Mathews, Ashok, Maxwell, Fiona, McClellan, Stuart, Millar, Tracey, Morris, Zoe, Morse, Tim, Mumford, Colin, Murray, Katherine, Myles, Lynn, Nimmo, Graham, Ng, Yi, Pal, Suvankar, Rannikmae, Kristiina, Rhodes, Jonathan, Ross, Jerard, Russell, Tim, Sandercock, Peter, Sellar, Robin, Shanmuganathan, Mano, Shekhar, Himanshu, Simms, Henry, Sittampalam, Mara, Soleiman, Hamza, Spiers, Helen, Statham, Patrick, Stavrinos, Neo, Stone, Jon, Stuart, Joyce, Sudlow, Cathie, Summers, David, Taylor, Pat, Torgersen, Antonia, van Dijke, Margarethe, Walker, Robert, Weller, Belinda, Whiteley, William, Whittle, Ian, Will, Robert, Young, Wendy, Anderson, Judith, Broadbent, Seona, Butler, Laura, Caesar, Dave, Cantley, Patricia, Carter, Jonathan, Clegg, Gareth, Coull, Andrew, Crosswaite, Alastair, Dear, James, Dummer, Simon, Duncan, Fiona, Elder-Gracie, Trish, Enright, Kate, Fitzgerald, Tom, Fothergill, Jane, Frier, Brian, Grant, David, Gray, Alasdair, Hart, Simon, Henderson, Robin, Jaap, Alan, Leigh-Smith, Simon, Jones, Michael, Masson, Moyra, McCallum, Lynn, McKechnie, Martin, McKillop, Graham, Mead, Gillian, Morley, Wendy, Morrow, Billie, Morrow, Frank, Murchison, Jon, Murphy, Ross, Ng, Jasmine, Ogundipe, Olayinka, Patel, Dilip, Pollock, Alison, Reed, Matthew, Roberts, Geraint, Selvarajah, Johann, Smith, Randy, Stirling, Claire, Turner, Neil, Wilson, Matthew, Yordanov, Stanko, Bell, Nicola, Chambers, Sarah, Dewar, Sandra, Farquhar, Donald, Harmouche, Ali, Jacob, Ashok, Jackson, Katherine, Knox, Anne, McCafferty, Jon, Moultrie, Sam, Munang, Latana, Noble, Donald, Ramsay, Scott, Spence, Linda, Threlfall, Bethany, Williams, Adrian, Wilson, James, Fitzgerald, Alastair, Jamieson, Andrew, Lange, Peter, McIntosh, Andrew, Morrison, Lewis, and Todd, Iain

Published
2015
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4. Tissue-Specific Immunopathology in Fatal COVID-19

Author

Dorward, David A., primary, Russell, Clark D., additional, Um, In Hwa, additional, Elshani, Mustafa, additional, Armstrong, Stuart D., additional, Penrice-Randal, Rebekah, additional, Millar, Tracey, additional, Lerpiniere, Chris E. B., additional, Tagliavini, Giulia, additional, Hartley, Catherine S., additional, Randle, Nadine P., additional, Gachanja, Naomi N., additional, Potey, Philippe M. D., additional, Dong, Xiaofeng, additional, Anderson, Alison M., additional, Campbell, Victoria L., additional, Duguid, Alasdair J., additional, Al Qsous, Wael, additional, BouHaidar, Ralph, additional, Baillie, J. Kenneth, additional, Dhaliwal, Kevin, additional, Wallace, William A., additional, Bellamy, Christopher O. C., additional, Prost, Sandrine, additional, Smith, Colin, additional, Hiscox, Julian A., additional, Harrison, David J., additional, and Lucas, Christopher D., additional

Published
2021
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7. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism

Author

MacAskill, Mark G., primary, Stadulyte, Agne, additional, Williams, Lewis, additional, Morgan, Timaeus E.F., additional, Sloan, Nikki L., additional, Alcaide-Corral, Carlos J., additional, Walton, Tashfeen, additional, Wimberley, Catriona, additional, McKenzie, Chris-Anne, additional, Spath, Nick, additional, Mungall, William, additional, BouHaidar, Ralph, additional, Dweck, Marc R., additional, Gray, Gillian A., additional, Newby, David E., additional, Lucatelli, Christophe, additional, Sutherland, Andrew, additional, Pimlott, Sally L., additional, and Tavares, Adriana A.S., additional

Published
2020
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8. Tissue-specific tolerance in fatal Covid-19

Author

Dorward, David A, primary, Russell, Clark D, additional, Um, In Hwa, additional, Elshani, Mustafa, additional, Armstrong, Stuart D, additional, Penrice-Randal, Rebekah, additional, Millar, Tracey, additional, Lerpiniere, Chris EB, additional, Tagliavini, Giulia, additional, Hartley, Catherine S, additional, Randle, Nadine P, additional, Gachanja, Naomi N, additional, Potey, Philippe MD, additional, Anderson, Alison M, additional, Campbell, Victoria L, additional, Duguid, Alasdair J, additional, Qsous, Wael Al, additional, BouHaidar, Ralph, additional, Baillie, J Kenneth, additional, Dhaliwal, Kevin, additional, Wallace, William A, additional, Bellamy, Christopher OC, additional, Prost, Sandrine, additional, Smith, Colin, additional, Hiscox, Julian A, additional, Harrison, David J, additional, and Lucas, Christopher D, additional

Published
2020
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17. Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study.

Author

Loan, James JM, Gane, Angus B, Middleton, Laura, Sargent, Brendan, Moullaali, Tom James, Rodrigues, Mark A, Cunningham, Laura, Wardlaw, Joanna, Salman, Rustam Al-Shahi, Samarasekera, Neshika, Addison, Anne, Ahmad, Kate, Alhadad, Syed, Andrews, Peter, Bisset, Elaine, Bodkin, Peter, Bouhaidar, Ralph, Brennan, Paul, Campbell, Brian, and Chandran, Siddharthan

Subjects
INTRACEREBRAL hematoma, CEREBRAL hemorrhage, SURVIVAL rate, HEMATOMA, EDEMA, COHORT analysis
Abstract

Background: Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims: In a community-based study, we aimed to investigate the existence, strength, direction, and independence of associations between intracerebral hemorrhage and peri-hematomal edema volumes on diagnostic brain CT and one-year functional outcome and long-term survival. Methods: We identified all adults, resident in Lothian, diagnosed with first-ever, symptomatic spontaneous intracerebral hemorrhage between June 2010 and May 2013 in a community-based, prospective inception cohort study. We defined regions of interest manually and used a semi-automated approach to measure intracerebral hemorrhage volume, peri-hematomal edema volume, and the sum of these measurements (total lesion volume) on first diagnostic brain CT performed at ≤3 days after symptom onset. The primary outcome was death or dependence (scores 3–6 on the modified Rankin Scale) at one-year after intracerebral hemorrhage. Results: Two hundred ninety-two (85%) of 342 patients (median age 77.5 y, IQR 68–83, 186 (54%) female, median time from onset to CT 6.5 h (IQR 2.9–21.7)) were dead or dependent one year after intracerebral hemorrhage. Peri-hematomal edema and intracerebral hemorrhage volumes were colinear (R 2 = 0.77). In models using both intracerebral hemorrhage and peri-hematomal edema, 10 mL increments in intracerebral hemorrhage (adjusted odds ratio (aOR) 1.72 (95% CI 1.08–2.87); p = 0.029) but not peri-hematomal edema volume (aOR 0.92 (0.63–1.45); p = 0.69) were independently associated with one-year death or dependence. 10 mL increments in total lesion volume were independently associated with one-year death or dependence (aOR 1.24 (1.11–1.42); p = 0.0004). Conclusion: Total volume of intracerebral hemorrhage and peri-hematomal edema, and intracerebral hemorrhage volume alone on diagnostic brain CT, undertaken at three days or sooner, are independently associated with death or dependence one-year after intracerebral hemorrhage, but peri-hematomal edema volume is not. Data access statement: Anonymized summary data may be requested from the corresponding author. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Baálat 3.4

Author

Turk, Elisabeth E. and BouHaidar, Ralph

Published
2007

22. Báalat

Author

BouHaidar, Ralph and Türk, Elisabeth

Published
2007

23. Baʼalat

Author

Türk, Elisabeth E. and BouHaidar, Ralph

Published
2006

24. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism.

Author

MacAskill, Mark G., Stadulyte, Agne, Williams, Lewis, Morgan, Timaeus E. F., Sloan, Nikki L., Alcaide- Corral, Carlos J., Walton, Tashfeen, Wimberley, Catriona, McKenzie, Chris-Anne, Spath, Nick, Mungall, William, BouHaidar, Ralph, Dweck, Marc R., Gray, Gillian A., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Published
2021
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25. Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism.

Author

MacAskill, Mark G., Stadulyte, Agne, Williams, Lewis, Morgan, Timaeus E. F., Sloan, Nikki L., Alcaide-Corral, Carlos J., Walton, Tashfeen, Wimberley, Catriona, McKenzie, Chris-Anne, Spath, Nick, Mungall, William, BouHaidar, Ralph, Dweck, Marc R., Gray, Gillian A., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Published
2020
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31. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18 F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism.

Author

MacAskill MG, Stadulyte A, Williams L, Morgan TEF, Sloan NL, Alcaide-Corral CJ, Walton T, Wimberley C, McKenzie CA, Spath N, Mungall W, BouHaidar R, Dweck MR, Gray GA, Newby DE, Lucatelli C, Sutherland A, Pimlott SL, and Tavares AAS

Subjects
Animals, Fluorine Radioisotopes analysis, Inflammation immunology, Macrophages cytology, Macrophages immunology, Male, Myocardial Infarction genetics, Myocardial Infarction metabolism, Radioactive Tracers, Rats, Sprague-Dawley, Receptors, GABA genetics, Rats, Macrophages metabolism, Myocardial Infarction diagnostic imaging, Myocardial Infarction immunology, Polymorphism, Single Nucleotide, Positron Emission Tomography Computed Tomography, Receptors, GABA metabolism
Abstract

Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory biomarker. The aims of this study were to screen novel, fluorinated, TSPO radiotracers for susceptibility to the rs6971 genetic polymorphism using in vitro competition binding assays in human brain and heart; assess whether the in vivo characteristics of our lead radiotracer, 18 F-LW223, are suitable for clinical translation; and validate whether 18 F-LW223 can detect macrophage-driven inflammation in a rat MI model. Methods: Fifty-one human brain and 29 human heart tissue samples were screened for the rs6971 polymorphism. Competition binding assays were conducted with 3 H-PK11195 and the following ligands: PK11195, PBR28, and our novel compounds (AB5186 and LW223). Naïve rats and mice were used for in vivo PET kinetic studies, radiometabolite studies, and dosimetry experiments. Rats underwent permanent coronary artery ligation and were scanned using PET/CT with an invasive input function at 7 d after MI. For quantification of PET signal in the hypoperfused myocardium, K 1 (rate constant for transfer from arterial plasma to tissues) was used as a surrogate marker of perfusion to correct the binding potential for impaired radiotracer transfer from plasma to tissue (BP TC ). Results: LW223 binding to TSPO was not susceptible to the rs6971 genetic polymorphism in human brain and heart samples. In rodents, 18 F-LW223 displayed a specific uptake consistent with TSPO expression, a slow metabolism in blood (69% of parent at 120 min), a high plasma free fraction of 38.5%, and a suitable dosimetry profile (effective dose of 20.5-24.5 μSv/MBq). 18 F-LW223 BP TC was significantly higher in the MI cohort within the infarct territory of the anterior wall relative to the anterior wall of naïve animals (32.7 ± 5.0 vs. 10.0 ± 2.4 cm 3 /mL/min, P ≤ 0.001). Ex vivo immunofluorescent staining for TSPO and CD68 (macrophage marker) resulted in the same pattern seen with in vivo BP TC analysis. Conclusion: 18 F-LW223 is not susceptible to the rs6971 genetic polymorphism in in vitro assays, has favorable in vivo characteristics, and is able to accurately map macrophage-driven inflammation after MI., (© 2021 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2021
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