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4 results on '"Bouke J Duijnisveld"'

1. Mortality and revision rate of cemented and uncemented hemiarthroplasty after hip fracture: an analysis of the Dutch Arthroplasty Register (LROI)

Author

Bouke J Duijnisveld, Koen L M Koenraadt, Liza N van Steenbergen, and Stefan B T Bolder

Subjects
Orthopedic surgery, RD701-811
Abstract

Background and purpose — Femoral neck fractures are commonly treated with cemented or uncemented hemiarthroplasties (HA). We evaluated differences in mortality and revision rates in this fragile patient group. Patients and methods — From January 1, 2007 until December 31, 2016, 22,356 HA procedures from the Dutch Arthroplasty Register (LROI) were included. For each HA, follow-up until death, revision, or end of follow-up (December 31, 2016) was determined. The crude revision rate was determined by competing risk analysis. Multivariable Cox regression analyses were performed to evaluate the effect of fixation method (cemented vs. uncemented) on death or revision. Age, sex, BMI, Orthopaedic Data Evaluation Panel (ODEP) rating, ASA grade, surgical approach, and previous surgery were included as potential confounders. Results — 1-year mortality rates did not differ between cemented and uncemented HA. 9-year mortality rates were 53% (95% CI 52–54) in cemented HA compared to 56% (CI 54–58) in uncemented HA. Multivariable Cox regression analysis showed similar mortality between cemented and uncemented HA (HR 1.0, CI 0.96–1.1). A statistically significantly lower 9-year revision rate of 3.1% (CI 2.7–3.6) in cemented HA compared with 5.1% (CI 4.2–6.2) in the uncemented HA was found with a lower hazard ratio for revision in cemented compared with uncemented HA (HR 0.56, CI 0.47–0.67). Interpretation — Long-term mortality rates did not differ between patients with a cemented or uncemented HA after an acute femoral neck fracture. Revision rates were lower in cemented compared with uncemented HA.

Published
2020
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2. No Learning Curve of the Direct Superior Approach in Total Hip Arthroplasty

Author

Bouke J Duijnisveld, Joost A A M van denHout, Robert Wagenmakers, Koen L M Koenraadt, and Stefan B T Bolder

Subjects
Direct superior approach, Learning curve, Mini posterior approach, Total hip arthroplasty, Orthopedic surgery, RD701-811
Abstract

Objectives To assess the learning curve of the direct superior approach (DSA) for total hip arthroplasty (THA) and to compare surgical, clinical, and radiological results with a matched control group using the mini posterior approach (MPA). Methods A prospective cohort study was performed from October 2016 to May 2017 including our first 52 patients undergoing THA using the DSA. Patients with primary osteoarthritis or osteonecrosis and a body mass index (BMI)

Published
2020
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3. No Learning Curve of the Direct Superior Approach in Total Hip Arthroplasty

Author

Joost A.A.M. van den Hout, Koen L. M. Koenraadt, Robert Wagenmakers, Bouke J Duijnisveld, and Stefan B T Bolder

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Arthroplasty, Replacement, Hip, Periprosthetic, Prom, Prosthesis, Osteoarthritis, Hip, Iliotibial tract, 03 medical and health sciences, Disability Evaluation, 0302 clinical medicine, lcsh:Orthopedic surgery, medicine, Humans, Direct superior approach, Orthopedics and Sports Medicine, Prospective Studies, Prospective cohort study, Learning curve, Aged, Pain Measurement, 030222 orthopedics, Clinical Article, business.industry, Osteonecrosis, Repeated measures design, Middle Aged, Mini posterior approach, Surgery, body regions, lcsh:RD701-811, medicine.anatomical_structure, Clinical Articles, Patient-reported outcome, Female, Total hip arthroplasty, Implant, business, 030217 neurology & neurosurgery
Abstract

OBJECTIVES To assess the learning curve of the direct superior approach (DSA) for total hip arthroplasty (THA) and to compare surgical, clinical, and radiological results with a matched control group using the mini posterior approach (MPA). METHODS A prospective cohort study was performed from October 2016 to May 2017 including our first 52 patients undergoing THA using the DSA. Patients with primary osteoarthritis or osteonecrosis and a body mass index (BMI)

Published
2019

4. Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage

Author

Wouter, den Hollander, Yolande F M, Ramos, Nils, Bomer, Stefan, Elzinga, Ruud, van der Breggen, Nico, Lakenberg, Wesley J, de Dijcker, H Eka D, Suchiman, Bouke J, Duijnisveld, Jeanine J, Houwing-Duistermaat, P Eline, Slagboom, Steffan D, Bos, Rob G H H, Nelissen, and Ingrid, Meulenbelt

Subjects
Cartilage, Articular, Male, Osteoarthritis, Humans, CpG Islands, Female, DNA Methylation, Transcriptome, Polymorphism, Single Nucleotide, Epigenesis, Genetic
Abstract

To identify osteoarthritis (OA) progression-modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic determinants in end-stage disease.Transcriptional activity of CpG was assessed using gene expression data and DNA methylation data for preserved and lesional articular cartilage samples. Disease-responsive transcriptionally active CpG were identified by means of differential methylation between preserved and lesional cartilage. Transcriptionally relevant genetic determinants were addressed by means of single-nucleotide polymorphisms (SNPs) proximal to the OA-responsive transcriptionally active CpG. Statistical analyses were corrected for age, sex, joint, and technical covariates. A random effect was included to correct for possible correlations between paired samples.Of 9,838 transcribed genes in articular cartilage, 2,324 correlated with the methylation status of 3,748 transcriptionally active CpG; both negative (n = 1,741) and positive (n = 2,007) correlations were observed. Hypomethylation and hypermethylation (false discovery rate of0.05, |Δβ| 0.05) were observed for 62 and 25 transcriptionally active CpG, respectively, covering 70 unique genes. Enrichment for developmental and extracellular matrix maintenance pathways indicated possible reactivation of endochondral ossification. Finally, we observed 31 and 26 genes for which methylation and expression, respectively, were additionally affected by genetic variation.We identified tissue-specific genes involved in OA disease progression, reflected by genetic and pathologic epigenetic regulation of transcription, primarily at genes involved in development. Therefore, transcriptionally active SNPs near these genes may serve as putative susceptibility alleles. Our results constitute an important step toward understanding the reported widespread epigenetic changes occurring in OA articular cartilage and toward subsequent development of treatments targeting disease-driving pathways.

Published
2014

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