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293 results on '"Boulanger, N."'

1. The two-thirds power law derived from an higher-derivative action

Author

Boulanger, N., Buisseret, F., Dierick, F., and White, O.

Subjects
Physics - Classical Physics, Physics - Biological Physics
Abstract

The two-thirds power law is a link between angular speed $\omega$ and curvature $\kappa$ observed in voluntary human movements: $\omega$ is proportional to $\kappa^{2/3}$. Squared jerk is known to be a Lagrangian leading to the latter law. We propose that a broader class of higher-derivative Lagrangians leads to the two-thirds power law and we perform the Hamiltonian analysis leading to action-angle variables through Ostrogradski's procedure. In this framework, squared jerk appears as an action variable and its minimization may be related to power expenditure minimization during motion. The identified higher-derivative Lagrangians are therefore natural candidates for cost functions, i.e. movement functions that are targeted to be minimal when one individual performs a voluntary movement., Comment: 17 pages, 1 figure

Published
2024
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2. Diffusion in Phase Space as a Tool to Assess Variability of Vertical Centre-of-Mass Motion During Long-Range Walking

Author

Boulanger, N., Buisseret, F., Dehouck, V., Dierick, F., and White, O.

Subjects
Physics - Classical Physics
Abstract

When a Hamiltonian system undergoes a stochastic, time-dependent anharmonic perturbation, the values of its adiabatic invariants as a function of time follow a distribution whose shape obeys a Fokker-Planck equation. The effective dynamics of the body's centre-of-mass during human walking is expected to represent such a stochastically perturbed dynamical system. By studying, in phase space, the vertical motion of the body's centre-of-mass of 25 healthy participants walking for 10-minutes at spontaneous speed, we show that the distribution of the adiabatic invariant is compatible with the solution of a Fokker-Planck equation with constant diffusion coefficient. The latter distribution appears to be a promising new tool for studying the long-range kinematic variability of walking.

Published
2023
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3. A First-Quantized Model For Unparticles and Gauge Theories Around Conformal Window

Author

Boulanger, N., Buisseret, F., and Lhost, G.

Subjects
High Energy Physics - Theory, High Energy Physics - Lattice
Abstract

We first quantize the action proposed by Casalbuoni and Gomis in [Phys. Rev. D \textbf{90}, 026001 (2014)], an action that describes two massless relativistic scalar particles interacting via a conformally invariant potential. The spectrum is a continuum of massive states that may be interpreted as unparticles. We then obtain in a similar way the mass operator for a deformed action in which two terms are introduced that break the conformal symmetry: a mass term and an extra position-dependent coupling constant. A simple Ansatz for the latter leads to a mass operator with linear confinement in terms of an effective string tension $\sigma\,$. The quantized model is confining when $\sigma\neq0$ and its mass spectrum shows Regge trajectories. We propose a tensionless limit in which highly excited confined states reduce to (gapped) unparticles. Moreover, the low-lying confined bound states become massless in the latter limit as a sign of conformal symmetry restoration and the ratio between their masses and $\sqrt\sigma$ stays constant. The originality of our approach is that it applies to both confining and conformal phases via an effective interacting model., Comment: v2 to be published in Universe (MDPI)

Published
2021
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5. Motor strategies and adiabatic invariants: The case of rhythmic motion in parabolic flights

Author

Boulanger, N., Buisseret, F., Dehouck, V., Dierick, F., and White, O.

Subjects
Physics - Classical Physics, Physics - Space Physics
Abstract

The role of gravity in human motor control is at the same time obvious and difficult to isolate. It can be assessed by performing experiments in variable gravity. We propose that adiabatic invariant theory may be used to reveal nearly-conserved quantities in human voluntary rhythmic motion, an individual being seen as a complex time-dependent dynamical system with bounded motion in phase-space. We study an explicit realization of our proposal: An experiment in which we asked participants to perform $\infty-$ shaped motion of their right arm during a parabolic flight, either at self-selected pace or at a metronome's given pace. Gravity varied between $0$ and $1.8$ $g$ during a parabola. We compute the adiabatic invariants in participant's frontal plane assuming a separable dynamics. It appears that the adiabatic invariant in vertical direction increases linearly with $g$, in agreement with our model. Differences between the free and metronome-driven conditions show that participants' adaptation to variable gravity is maximal without constraint. Furthermore, motion in the participant's transverse plane induces trajectories that may be linked to higher-derivative dynamics. Our results show that adiabatic invariants are relevant quantities to show the changes in motor strategy in time-dependent environments., Comment: To appear in Phys Rev E

Published
2021
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6. Adiabatic invariants drive rhythmic human motion in variable gravity

Author

Boulanger, N., Buisseret, F., Dehouck, V., Dierick, F., and White, O.

Subjects
Physics - Medical Physics, Physics - Biological Physics
Abstract

Natural human movements are stereotyped. They minimise cost functions that include energy, a natural candidate from mechanical and physiological points of view. In time-changing environments, however, motor strategies are modified since energy is no longer conserved. Adiabatic invariants are relevant observables in such cases, although they have not been investigated in human motor control so far. We fill this gap and show that the theory of adiabatic invariants explains how humans move when gravity varies.

Published
2019
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9. TIGrE : TIBOLA dans le Grand-Est

Author

Kotzyba, J., primary, Baux, E., additional, Hansmann, Y., additional, Boyer, P., additional, Martinot, M., additional, Martha, B., additional, Kaeuffer, C., additional, Bonijoly, T., additional, Boulanger, N., additional, and Lefèvre, B., additional

Published
2024
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11. Neutron Reflectivity for Testing Graphene Oxide Films Sorption of EuCl3 in Ethanol Solution

Author

Nordenström, A., Boulanger, N., Vorobiev, A., (0000-0003-2234-4173) Amidani, L., Bauters, S., Galanzew, J., (0000-0003-4447-4542) Kvashnina, K., Talyzin, A., Nordenström, A., Boulanger, N., Vorobiev, A., (0000-0003-2234-4173) Amidani, L., Bauters, S., Galanzew, J., (0000-0003-4447-4542) Kvashnina, K., and Talyzin, A.

Abstract

Neutron reflectivity (NR) was used to study the sorption of Eu(III) by graphene oxide (GO) films exposed to ethanol solution of EuCl3. Most of the earlier sorption studies have been performed using GO dispersed in solution. In contrast, layered structure of GO films imposes limitations for penetration of ions between individual sheets. The analysis of NR data recorded before and after sorption under vacuum demonstrates an increase of GO film thickness due to sorption by 35–40%. The characterization of chemical state of Eu(III) sorbed by GO films by X-ray absorption near-edge structure (XANES) in high-energy resolution fluorescence detection (HERFD) method at the Eu L3 edge reveals that it remains the same as in anhydrous EuCl3. Analysis of all collected data including reference experiments with bulk GO samples allows to conclude that EuCl3 penetrates into GO interlayers with ethanol solution and remains trapped in interlayers after evaporation of ethanol. Sorption of EuCl3 results in nearly complete amorphization of film and likely formation of voids, thus making NR models based on specific volume of unit cell not valid for quantitative evaluation of Eu sorption. Limitations of NR method must be taken into account in future studies of sorption by thin films.

Published
2024

14. Constituent gluon interpretation of glueballs and gluelumps

Author

Boulanger, N., Buisseret, F., Mathieu, V., and Semay, C.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Lattice
Abstract

Arguments are given that support the interpretation of the lattice QCD glueball and gluelump spectra in terms of bound states of massless constituent gluons with helicity-1. In this scheme, the mass hierarchy of the currently known gluelumps and glueballs is mainly due to the number of constituent gluons and can be understood within a simple flux tube model. It is also argued that the lattice QCD $0^{+-}$ glueball should be seen as a four-gluon bound state. The flux tube model allows for a parameter-free computation of its mass, which is in good agreement with lattice QCD., Comment: 3 figures, use of package youngtab

Published
2008
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15. Gravitational Lorentz Violations from M-Theory

Author

Bekaert, X., Boulanger, N., and Vazquez-Poritz, J. F.

Subjects
High Energy Physics - Theory, High Energy Physics - Phenomenology
Abstract

In an attempt to bridge the gap between M-theory and braneworld phenomenology, we present various gravitational Lorentz-violating braneworlds which arise from p-brane systems. Lorentz invariance is still preserved locally on the braneworld. For certain p-brane intersections, the massless graviton is quasi-localized. This also results from an M5-brane in a C-field. In the case of a p-brane perturbed from extremality, the quasi-localized graviton is massive. For a braneworld arising from global AdS_5, gravitons travel faster when further in the bulk, thereby apparently traversing distances faster than light., Comment: 13 pages, 1 figure, LaTeX, references added, minor corrections and additions

Published
2002
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16. A derivation of Weyl gravity

Author

Boulanger, N. and Henneaux, M.

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology
Abstract

In this paper, two things are done. (i) Using cohomological techniques, we explore the consistent deformations of linearized conformal gravity in 4 dimensions. We show that the only possibility involving no more than 4 derivatives of the metric (i.e., terms of the form $\partial^4 g_{\mu \nu}$, $\partial^3 g_{\mu \nu} \partial g_{\alpha \beta}$, $\partial^2 g_{\mu \nu} \partial^2g_{\alpha \beta}$, $\partial^2 g_{\mu \nu} \partial g_{\alpha \beta} \partial g_{\rho \sigma}$ or $\partial g_{\mu \nu} \partial g_{\alpha \beta} \partial g_{\rho \sigma} \partial g_{\gamma \delta}$ with coefficients that involve undifferentiated metric components - or terms with less derivatives) is given by the Weyl action $\int d^4x \sqrt{-g} W_{\a\b\g\d} W^{\a\b\g\d}$, in much the same way as the Einstein-Hilbert action describes the only consistent manner to make a Pauli-Fierz massless spin-2 field self-interact with no more than 2 derivatives. No a priori requirement of invariance under diffeomorphisms is imposed: this follows automatically from consistency. (ii) We then turn to "multi-Weyl graviton" theories. We show the impossibility to introduce cross-interactions between the different types of Weyl gravitons if one requests that the action reduces, in the free limit, to a sum of linearized Weyl actions. However, if different free limits are authorized, cross-couplings become possible. An explicit example is given. We discuss also how the results extend to other spacetime dimensions., Comment: This work was presented in part at the meeting of the Deutsche Physikalische Gesellschaft held in Bonn, 26-29 March 2001. To appear in Annalen der Physik

Published
2001
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18. Effect of Chain Length on Swelling Transitions of Brodie Graphite Oxide in Liquid 1-Alcohols

Author

Iakunkov, A., Nordenström, A., Boulanger, N., Li, G., (0000-0001-6393-2778) Hennig, C., Jørgensen, M. R. V., Kantor, I., Talyzin, . A. V., Iakunkov, A., Nordenström, A., Boulanger, N., Li, G., (0000-0001-6393-2778) Hennig, C., Jørgensen, M. R. V., Kantor, I., and Talyzin, . A. V.

Abstract

Swelling is the most fundamental property of graphite oxides (GO). Here, a structural study of Brodie graphite oxide (BGO) swelling in a set of long chain 1-alcohols (named C11 to C22 according to the number of carbons) performed using synchrotron radiation X-ray diffraction at elevated temperatures is reported. Even the longest of tested alcohols (C22) is found to intercalate BGO with enormous expansion of the interlayer distance from ≈6Å up to ≈63Å, the highest expansion of GO lattice ever reported. Swelling transitions from low temperature alpha-phase to high temperature beta-phase are found for BGO in all alcohols in the C11–C22 set. The transitions correspond to decrease of inter-layer distance correlating with the length of alcohol molecules, and change in their orientation from perpendicular to GO planes to layered parallel to GO (Type II transitions). These transitions are very different compared to BGO swelling transitions (Type I) found in smaller alcohols and related to insertion/de-insertion of additional layer of alcohol parallel to GO. Analysis of general trends in the whole set of 1-alcohols (C1 to C22) shows that the 1-alcohol chain length defines the type of swelling transition with Type I found for alcohols with C<10 and Type II for C>10.

Published
2023

20. Temperature dependent swelling transitions in MXene Ti3C2Tx

Author

Iakunkov, A., Nordenström, A., Boulanger, N., (0000-0001-6393-2778) Hennig, C., Baburin, I., Talyzin, A., Iakunkov, A., Nordenström, A., Boulanger, N., (0000-0001-6393-2778) Hennig, C., Baburin, I., and Talyzin, A.

Abstract

Swelling is a property of hydrophilic layered materials, which enables the penetration of polar solvents into an interlayer space with expansion of the lattice. Here we report an irreversible swelling transition, which occurs in MXenes immersed in excess dimethyl sulfoxide (DMSO) upon heating at 362-370 K with an increase in the interlayer distance by 4.2 Å. The temperature dependence of MXene Ti3C2Tx swelling in several polar solvents was studied using synchrotron radiation X-ray diffraction. MXenes immersed in excess DMSO showed a step-like increase in the interlayer distance from 17.73 Å at 280 K to 22.34 Å above ∼362 K. The phase transformation corresponds to a transition from the MXene structure with one intercalated DMSO layer into a two-layer solvate phase. The transformation is irreversible and the expanded phase remains after cooling back to room temperature. A similar phase transformation was observed also for MXene immersed in a 2 : 1 H2O : DMSO solvent ratio but at a lower temperature. The structure of MXene in the mixed solvent below 328 K was affected by the interstratification of differently hydrated (H2O)/solvated (DMSO) layers. Above the temperature of the transformation, the water was expelled from MXene interlayers and the formation of a pure two-layer DMSO-MXene phase was found. No changes in the swelling state were observed for MXenes immersed in DMSO or methanol at temperatures below ambient down to 173 K. Notably, MXenes do not swell in 1-alcohols larger than ethanol at ambient temperature. Changing the interlayer distance of MXenes by simple temperature cycling can be useful in membrane applications, e.g. when a larger interlayer distance is required for the penetration of ions and molecules into membranes. Swelling is also very important in electrode materials since it allows penetration of the electrolyte ions into the interlayers of the MXene structure.

Published
2022

21. High surface area “3D Graphene Oxide” for enhanced sorption of radionuclides

Author

Boulanger, N., Kuzenkova, A. S., Iakunkov, A., Nordenström, A., Romanchuk, A. Y., Trigub, A. L., Zasimov, P. V., Podana, M., Enachescu, M., Bauters, S., Amidani, L., Kvashnina, K. O., Kalmykov, S. N., Talyzin, A. V., Boulanger, N., Kuzenkova, A. S., Iakunkov, A., Nordenström, A., Romanchuk, A. Y., Trigub, A. L., Zasimov, P. V., Podana, M., Enachescu, M., Bauters, S., Amidani, L., Kvashnina, K. O., Kalmykov, S. N., and Talyzin, A. V.

Abstract

Earlier studies demonstrated that graphene oxide (GO) with large number of defects is favorable for the sorption of radionuclides. Here we report oxidation treatment which converts high surface area activated reduced graphene oxide (arGO) into a 3D analogue of defect-rich GO (dGO). Oxidation of arGO using ammonium persulfate results in oxidation corresponding to carbon to oxygen ratio C/O=3.3, similar to the oxidation state of graphene oxide while preserving high BET surface area of about 880 m2/g. Analysis of surface oxidized arGO shows high abundance of oxygen functional groups very similar to dGO and hydrophilic properties. The “3D graphene oxide” showed high sorption capacity for U(VI) removal in an extraordinary broad interval of pH. Notably, the surface oxidized carbon material has a rigid 3D structure with micropores accessible for penetration of radionuclide ions. Therefore, the bulk “3D GO” can be used as a sorbent directly without dispersing, the step required for GO to make its surface area accessible for pollutants

Published
2022

24. Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

Author

Talagrand-Reboul, E., Westermann, B., Raess M., A., Schnell, G., Cantero, P., Barthel, C., Ehret-Sabatier, Laurence, JAULHAC, B., Boulanger, N., Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Université de Strasbourg (UNISTRA), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
skin, proteomics, tick-borne diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Borrelia, lcsh:R, lcsh:Medicine, Lyme, markers of infection, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, Article
Abstract

International audience; Tick-borne diseases affecting humans and animals are on the rise worldwide. Vaccines constitute an effective control measure, but very few are available. We selected Lyme borreliosis, a bacterial infection transmitted by the hard tick Ixodes, to validate a new concept to identify vaccine candidates. This disease is the most common tick-borne disease in the Northern Hemisphere. Although attempts to develop a vaccine exist, none have been successfully marketed. In tick-borne diseases, the skin constitutes a very specific environment encountered by the pathogen during its co-inoculation with tick saliva. In a mouse model, we developed a proteomic approach to identify vaccine candidates in skin biopsies. We identified 30 bacterial proteins after syringe inoculation or tick inoculation of bacteria. Discovery proteomics using mass spectrometry might be used in various tick-borne diseases to identify pathogen proteins with early skin expression. It should help to better develop sub-unit vaccines based on a cocktail of several antigens, associated with effective adjuvant and delivery systems of antigens. In all vector-borne diseases, the skin deserves further investigation to better define its role in the elaboration of protective immunity against pathogens.

Published
2020
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25. Facile fabrication of graphene-based high-performance microsupercapacitors operating at a high temperature of 150 °C

Author

Mishukova, Viktoriia, Boulanger, N., Iakunkov, A., Delekta, Szymon Sollami, Zhuang, X., Talyzin, A., Li, Jiantong, Mishukova, Viktoriia, Boulanger, N., Iakunkov, A., Delekta, Szymon Sollami, Zhuang, X., Talyzin, A., and Li, Jiantong

Abstract

Many industry applications require electronic circuits and systems to operate at high temperatures over 150 °C. Although planar microsupercapacitors (MSCs) have great potential for miniaturized on-chip integrated energy storage components, most of the present devices can only operate at low temperatures (<100 °C). In this work, we have demonstrated a facile process to fabricate activated graphene-based MSCs that can work at temperatures as high as 150 °C with high areal capacitance over 10 mF cm−2and good cycling performance. Remarkably, the devices exhibit no capacitance degradation during temperature cycling between 25 °C and 150 °C, thanks to the thermal stability of the active components., QC 20220425

Published
2021
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30. Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies

Author

Gocko, X. (X), Lenormand, C. (C), Lemogne, C. (C), Bouiller, K. (K), Gehanno, J.-F., Rabaud, C. (C), Perrot, S. (S), Eldin, C. (C), de Broucker, T. (T), Roblot, F. (F), Toubiana, J. (J), Sellal, F. (Francois), Vuillemet, F. (F), Sordet, C. (Christelle), Fantin, B. (B), Lina, G. (G), Sobas, C. (C), Jaulhac, B. (Benoit), Figoni, J. (J), Chirouze, C. (C), Hansmann, Y. (Yves), Hentgen, V. (V), Caumes, E. (E), Dieudonné, M. (M), Picone, O. (O), Bodaghi, B. (B), Gangneux, J.-P., Degeilh, B. (B), Partouche, H. (H), Saunier, A. (A), Sotto, A. (A), Raffetin, A. (A), Monsuez, J.-J., Michel, C. (C), Boulanger, N. (Nathalie), Cathebras, P. (P), Tattevin, P. (P), societies, e. (endorsed) b. (by) t. (the) f. (following) s. (scientific), Université de Strasbourg (UNISTRA), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Max Weber (CMW), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Laboratoire Chrono-environnement (UMR 6249) (LCE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Societies, Scientific, Insecticides, [SDV]Life Sciences [q-bio], Aucun, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Animals, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Tick-borne disease, Lyme Disease, Vaccines, Lyme borreliosis, business.industry, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, medicine.disease, 3. Good health, Primary Prevention, Infectious Diseases, Tick-Borne Diseases, France, Nervous System Diseases, business, 030217 neurology & neurosurgery
Abstract

International audience

Published
2019
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31. Borréliose de Lyme et autres maladies vectorielles à tiques. Recommandations des sociétés savantes françaises (Argumentaire I) : prévention, épidémiologie, circonstances du diagnostic

Author

Figoni, J, Chirouze, C, Hansmann, Y, Lemogne, C, Hentgen, V, Saunier, A, Bouiller, K, Gehanno, J F, Rabaud, C, Perrot, S, Caumes, E, Eldin, C, de Broucker, T, Jaulhac, B, Roblot, F, Toubiana, J, Sellal, F, Vuillemet, F, Sordet, C, Fantin, B, Lina, G, Gocko, X, Dieudonné, M, Picone, O., Bodaghi, B, Gangneux, Jean-Pierre, Degeilh, B, Partouche, H, Lenormand, C, Sotto, A, Raffetin, A, Monsuez, J J, Michel, C, Boulanger, N, Cathebras, P, Tattevin, P, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris-Est Marne-la-Vallée (UPEM), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm - Paris Descartes), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon, Departement de Neurologie (HCL), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Max Weber (CMW), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Strasbourg (UNISTRA), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Pontchaillou [Rennes], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Santé publique France, Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Prévention, Erythema migrans, Neuroborreliosis, Arthritis, [SDV]Life Sciences [q-bio], Borréliose de Lyme, Ticks, Arthrite, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Érythème migrant, France, Tiques, ComputingMilieux_MISCELLANEOUS, Neuroborréliose, Lyme borreliosis
Abstract

International audience

Published
2019
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34. Adiabatic invariants drive rhythmic human motion in variable gravity

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, Boulanger, N., Buisseret, F., Dehouck, V., Dierick, Frédéric, White, O., UCL - SSH/IPSY - Psychological Sciences Research Institute, Boulanger, N., Buisseret, F., Dehouck, V., Dierick, Frédéric, and White, O.

Abstract

n/a

Published
2020

35. Enhanced Sorption of Radionuclides by Defect-Rich Graphene Oxide

Author

Boulanger, N., Kuzenkova, A. S., Iakunkov, A., Romanchuk, A. Y., Trigub, A. L., Egorov, A. V., Bauters, S., (0000-0003-2234-4173) Amidani, L., Retegan, M., (0000-0003-4447-4542) Kvashnina, K., Kalmykov, S. N., Talyzin, A. V., Boulanger, N., Kuzenkova, A. S., Iakunkov, A., Romanchuk, A. Y., Trigub, A. L., Egorov, A. V., Bauters, S., (0000-0003-2234-4173) Amidani, L., Retegan, M., (0000-0003-4447-4542) Kvashnina, K., Kalmykov, S. N., and Talyzin, A. V.

Abstract

Extremely defect graphene oxide (dGO) is proposed as an advanced sorbent for treatment of radioactive waste and con-taminated natural waters. dGO prepared using a modified Hummers oxidation procedure, starting from reduced graphene oxide (rGO) as a precursor, shows significantly higher sorption of U(VI), Am(III) and Eu(III) compared to standard gra-phene oxides (GO). Earlier studies revealed the mechanism of radionuclide sorption related to defects in GO sheets. There-fore, explosive thermal exfoliation of graphite oxide was used to prepare rGO with large number of defects and holes. De-fects and holes are additionally introduced by Hummers oxidation of rGO thus providing extremely defect-rich material. Analysis of characterization by XPS, TGA, FTIR shows that dGO oxygen functionalization is predominantly related to de-fects, such as flake edges and edge atoms of holes, whereas standard GO exhibits oxygen functional groups mostly on the planar surface. The high abundance of defects in dGO results in a 15-fold increase in sorption capacity of U(VI) compared to standard Hummers GO. The improved sorption capacity of dGO is related to abundant carboxylic groups attached hole edge atoms of GO flakes as revealed by synchrotron-based extended X-ray absorption fine structure (EXAFS) and high-energy resolution fluorescence detected X-Ray absorption near edge structure (HERFD-XANES) spectroscopy.

Published
2020

36. Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis: prevention, epidemiology, diagnosis

Author

Figoni, J. (J), Chirouze, C. (C), Hansmann, Y. (Yves), Lemogne, C. (C), Hentgen, V. (V), Saunier, A. (A), Bouiller, K. (K), Gehanno, J. (J) F. (F), Rabaud, C. (C), Perrot, S. (S), Caumes, E. (E), Eldin, C. (C), de Broucker, T. (T), Jaulhac, B. (Benoit), Roblot, F. (F), Toubiana, J. (J), Sellal, F. (Francois), Vuillemet, F. (F), Sordet, C. (Christelle), Fantin, B. (B), Lina, G. (G), Gocko, X. (X), Dieudonné, M. (M), Picone, O. (O), Bodaghi, B. (B), Gangneux, J. (J) P. (P), Degeilh, B. (B), Partouche, H. (H), Lenormand, C. (Cedric), Sotto, A. (A), Raffetin, A. (A), Monsuez, J. (J) J. (J), Michel, C. (C), Boulanger, N. (Nathalie), Cathebras, P. (P), and Tattevin, P. (P)

Subjects
Aucun, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie
Abstract

Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. There is currently no situation in France when prophylactic antibiotics would be recommended. The incidence of Lyme borreliosis in France, estimated through a network of general practitioners (réseau Sentinelles), and nationwide coding system for hospital stays, has not significantly changed between 2009 and 2017, with a mean incidence estimated at 53 cases/100,000 inhabitants/year, leading to 1.3 hospital admission/100,000 inhabitants/year. Other tick-borne diseases are much more seldom in France: tick-borne encephalitis (around 20 cases/year), spotted-fever rickettsiosis (primarily mediterranean spotted fever, around 10 cases/year), tularemia (50–100 cases/year, of which 20% are transmitted by ticks), human granulocytic anaplasmosis (< 10 cases/year), and babesiosis (< 5 cases/year). The main circumstances of diagnosis for Lyme borreliosis are cutaneous manifestations (primarily erythema migrans, much more rarely borrelial lymphocytoma and atrophic chronic acrodermatitis), neurological (< 15% of cases, mostly meningoradiculitis and cranial nerve palsy, especially facial nerve) and rheumatologic (mostly knee monoarthritis, with recurrences). Cardiac and ophtalmologic manifestations are very rarely encountered.

Published
2019

37. Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission

Author

Boeuf, A. (Amandine), Schnell, G. (Gilles), Bernard, Q. (Quentin), Kern, A. (Aurelie), Westermann, B. (Benoît), Sabatier, L. (Laurence), Grillon, A. (Antoine), Schramm, F. (Frederic), Jaulhac, B. (Benoit), and Boulanger, N. (Nathalie)

Subjects
Aucun, bacterial infections and mycoses, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie
Abstract

Understanding the mechanism of pathogen transmission is essential for the development of strategies to reduce arthropod-borne diseases. The pharmaco- and immunomodulatory properties of insect and acarine saliva play an essential role in the efficiency of pathogen transmission. The skin as the site where arthropod saliva and pathogens are inoculated - represents the key interface in vector-borne diseases. We identified tick molecules potentially involved in pathogen transmission, using micro-HPLC and mass spectrometry, followed by in vitro assays on human skin cells. Histone H4 isolated from Ixodes ricinus salivary gland extract was identified as a molecule with a dissociating effect on human primary fibroblasts. This histone might be involved in the formation of the feeding pool formed around the tick mouthparts and responsible of tissue necrosis in the vertebrate host. Thanks to its selective antimicrobial activity, it may also sterilize the feeding pool and facilitate transmission of pathogens such as Borrelia burgdorferi sensu lato.

Published
2019

38. Erratum à « Borréliose de Lyme et autres maladies vectorielles à tiques. Recommandations des sociétés savantes françaises » [Med. Mal. Infect. 49 (2019) 296–317]

Author

Gocko, X., primary, Lenormand, C., additional, Lemogne, C., additional, Bouiller, K., additional, Gehanno, J.-F., additional, Rabaud, C., additional, Perrot, S., additional, Eldin, C., additional, de Broucker, T., additional, Roblot, F., additional, Toubiana, J., additional, Sellal, F., additional, Vuillemet, F., additional, Sordet, C., additional, Fantin, B., additional, Lina, G., additional, Sobas, C., additional, Jaulhac, B., additional, Figoni, J., additional, Chirouze, C., additional, Hansmann, Y., additional, Hentgen, V., additional, Caumes, E., additional, Dieudonné, M., additional, Picone, O., additional, Bodaghi, B., additional, Gangneux, J.-P., additional, Degeilh, B., additional, Partouche, H., additional, Saunier, A., additional, Sotto, A., additional, Raffetin, A., additional, Monsuez, J.-J., additional, Michel, C., additional, Boulanger, N., additional, Cathebras, P., additional, and Tattevin, P., additional

Published
2019
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39. Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis

Author

Jaulhac, B., primary, Saunier, A., additional, Caumes, E., additional, Bouiller, K., additional, Gehanno, J.F., additional, Rabaud, C., additional, Perrot, S., additional, Eldin, C., additional, de Broucker, T., additional, Roblot, F., additional, Toubiana, J., additional, Sellal, F., additional, Vuillemet, F., additional, Sordet, C., additional, Fantin, B., additional, Lina, G., additional, Sobas, C., additional, Gocko, X., additional, Figoni, J., additional, Chirouze, C., additional, Hansmann, Y., additional, Hentgen, V., additional, Cathebras, P., additional, Dieudonné, M., additional, Picone, O., additional, Bodaghi, B., additional, Gangneux, J.P., additional, Degeilh, B., additional, Partouche, H., additional, Lenormand, C., additional, Sotto, A., additional, Raffetin, A., additional, Monsuez, J.J., additional, Michel, C., additional, Boulanger, N., additional, Lemogne, C., additional, and Tattevin, P., additional

Published
2019
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40. Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis

Author

Figoni, J., primary, Chirouze, C., additional, Hansmann, Y., additional, Lemogne, C., additional, Hentgen, V., additional, Saunier, A., additional, Bouiller, K., additional, Gehanno, J.F., additional, Rabaud, C., additional, Perrot, S., additional, Caumes, E., additional, Eldin, C., additional, de Broucker, T., additional, Jaulhac, B., additional, Roblot, F., additional, Toubiana, J., additional, Sellal, F., additional, Vuillemet, F., additional, Sordet, C., additional, Fantin, B., additional, Lina, G., additional, Gocko, X., additional, Dieudonné, M., additional, Picone, O., additional, Bodaghi, B., additional, Gangneux, J.P., additional, Degeilh, B., additional, Partouche, H., additional, Lenormand, C., additional, Sotto, A., additional, Raffetin, A., additional, Monsuez, J.J., additional, Michel, C., additional, Boulanger, N., additional, Cathebras, P., additional, and Tattevin, P., additional

Published
2019
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42. Multilocus sequence typing of clinical Borreliella afzelii strains: population structure and differential ability to disseminate in humans

Author

Gallais, F. (Floriane), De Martino, S. (Sylvie) J. (J), Sauleau, E. (Eric-André) A. (A), Hansmann, Y. (Yves), Lipsker, D. (Dan), Lenormand, C. (Cédric), Talagrand-Reboul, E. (Emilie), Boyer, P. (Pierre) H. (H), Boulanger, N. (Nathalie), Jaulhac, B. (Benoit), and Schramm, F. (Frederic)

Subjects
bacterial infections and mycoses, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, Sciences du Vivant [q-bio]/Génétique
Abstract

BACKGROUND: Lyme borreliosis in humans results in a range of clinical manifestations, thought to be partly due to differences in the pathogenicity of the infecting strain. This study compared European human clinical strains of Borreliella afzelii (previously named Borrelia afzelii) using multilocus sequence typing (MLST) to determine their spatial distribution across Europe and to establish whether there are associations between B. afzelii genotypes and specific clinical manifestations of Lyme borreliosis. For this purpose, typing was performed on 63 strains, and data on a further 245 strains were accessed from the literature. RESULTS: All 308 strains were categorized into 149 sequence types (STs), 27 of which are described here for the first time. Phylogenetic and goeBURST analyses showed short evolutionary distances between strains. Although the main STs differed among the countries with the largest number of strains of interest (Germany, the Netherlands, France and Slovenia), the B. afzelii clinical strains were less genetically structured than those previously observed in the European tick population. Two STs were found significantly more frequently in strains associated with clinical manifestations involving erythema migrans, whereas another ST was found significantly more frequently in strains associated with disseminated manifestations, especially neuroborreliosis. CONCLUSIONS: The MLST profiles showed low genetic differentiation between B. afzelii strains isolated from patients with Lyme borreliosis in Europe. Also, clinical data analysis suggests the existence of lineages with differential dissemination properties in humans.

Published
2018

46. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders

Author

Féron, François-Xavier, Gepner, B, Lacassagne, E, Stephan, S, Mesnage, M, Blanchard, M, Boulanger, N, Tardif, C, Devèze, A, Rousseau, Sylvain, Suzuki, K, Belmonte, Jc, Khrestchatisky, M, Nivet, E, Erard-Garcia, M, Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigations Cliniques en Biothérapie (CBT 1409), INSERM, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Technologies avancées pour le génôme et la clinique (TAGC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Psychologie de la Connaissance, du Langage et de l'Émotion (PsyCLÉ), Aix Marseille Université (AMU), Département ORL, Assistance Publique - Hôpitaux de Marseille (APHM), Département Anesthésie, Gene Expression Laboratory, The Salk Institute for Biological Studies, Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Réponse immunitaire et developpement chez les insectes (RIDI - UPR 9002), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'ORL, CHU Nord, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel-Aix Marseille Université (AMU)-Université Gustave Eiffel, Neurobiologie intégrative et adaptative (NIA), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Strasbourg (UNISTRA)-Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Aix Marseille Université (AMU)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Aix Marseille Université (AMU)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Aix Marseille Université (AMU), and Tardif, Carole

Subjects
Adult, Male, Autism Spectrum Disorder, [SDV]Life Sciences [q-bio], autism spectrum disorders, [SHS.PSY]Humanities and Social Sciences/Psychology, MOCOS, Olfactory Receptor Neurons, [SHS.PSY] Humanities and Social Sciences/Psychology, Mice, Olfactory Mucosa, stem cells, Animals, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], neurotransmission, Caenorhabditis elegans, ComputingMilieux_MISCELLANEOUS, Mice, Inbred C57BL, Sulfurtransferases, autism spectrum disorders, neurotransmission , MOCOS, stem cells, [SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology, Original Article, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], France
Abstract

International audience; With an onset under the age of 3 years, autism spectrum disorders (ASDs) are now understood as diseases arising from pre-and/or early postnatal brain developmental anomalies and/or early brain insults. To unveil the molecular mechanisms taking place during the misshaping of the developing brain, we chose to study cells that are representative of the very early stages of ontogenesis, namely stem cells. Here we report on MOlybdenum COfactor Sulfurase (MOCOS), an enzyme involved in purine metabolism, as a newly identified player in ASD. We found in adult nasal olfactory stem cells of 11 adults with ASD that MOCOS is downregulated in most of them when compared with 11 age-and gender-matched control adults without any neuropsychiatric disorders. Genetic approaches using in vivo and in vitro engineered models converge to indicate that altered expression of MOCOS results in neurotransmission and synaptic defects. Furthermore, we found that MOCOS misexpression induces increased oxidative-stress sensitivity. Our results demonstrate that altered MOCOS expression is likely to have an impact on neurodevelopment and neurotransmission, and may explain comorbid conditions, including gastrointestinal disorders. We anticipate our discovery to be a fresh starting point for the study on the roles of MOCOS in brain development and its functional implications in ASD clinical symptoms. Moreover, our study suggests the possible development of new diagnostic tests based on MOCOS expression, and paves the way for drug screening targeting MOCOS and/or the purine metabolism to ultimately develop novel treatments in ASD.

Published
2016
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47. Tiques et maladies à tiques : biologie, écologie évolutive, épidémiologie

Author

McCoy, K.D. (ed.) and Boulanger, N. (ed.)

Abstract

Présentes dans tous les écosystèmes depuis des centaines de millions d'années, les tiques sont parmi les plus anciens arthropodes apparus sur Terre, exploitant leurs hôtes bien avant l'apparition de l'homme. Hématophages, elles sont responsables chez leurs hôtes d'une grande diversité de maladies, que ce soit par spoliation sanguine ou par transmission vectorielle de virus, de bactéries ou de parasites. Leur présence accrue dans l'environnement est à l'origine de nombreux cas d'encéphalites, de borrélioses de Lyme, de fièvres récurrentes, de babésioses; Ainsi, les infestations par les tiques et les maladies qu'elles transmettent constituent un véritable problème de santé pour l'homme et pour les animaux domestiques, tant en zone tropicale que tempérée. Pour dresser un état des connaissances complet sur les tiques, cet ouvrage collectif adopte une approche pluridisciplinaire. Il décrit la systématique et l'évolution, la biologie et l'écologie des tiques ainsi que les relations complexes qu'elles entretiennent avec leur hôte. Les agents de maladies infectieuses transmis, les modes de transmission, les méthodes de prévention des risques ainsi qu'un état des lieux sur la lutte contre les tiques sont également présentés.

Published
2015

48. Personal protection against biting insects and ticks

Author

Duvallet, G., Boulanger, N., Chandre, Fabrice, Colin de Verdière, N., Consigny, P.H., Delaunay, P., Depaquit, J., Doudier, B., Franc, M., Moulin, F., Pagès, F., Quatresous, I., Robert, Vincent, and Saviuc, P.

Subjects
RECOMMANDATIONS, TOXICITE, VECTEUR, ACARIEN PREDATEUR, PREVENTION SANITAIRE, INSECTE, ENFANT, GROSSESSE, INSECTICIDE CHIMIQUE, EPIDEMIE, METHODE DE LUTTE, MOUSTIQUE, MOUSTIQUAIRE IMPREGNEE, EDUCATION SANITAIRE
Published
2011

49. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders

Author

Féron, F, primary, Gepner, B, additional, Lacassagne, E, additional, Stephan, D, additional, Mesnage, B, additional, Blanchard, M-P, additional, Boulanger, N, additional, Tardif, C, additional, Devèze, A, additional, Rousseau, S, additional, Suzuki, K, additional, Izpisua Belmonte, J C, additional, Khrestchatisky, M, additional, Nivet, E, additional, and Erard-Garcia, M, additional

Published
2015
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50. Protection personnelle antivectorielle ou protection contre les insectes piqueurs et les tiques : recommandations de bonne pratique

Author

Legros, Fabrice, Duvallet, G., Boulanger, N., Chandre, Fabrice, Colin de Verdière, N., Consigny, P.H., Delaunay, P., Depaquit, J., Doudier, B., Franc, M., Moulin, F., Pagès, F., Prangé, A., Quatresous, I., Robert, Vincent, Saviuc, P., Auvin, S., Carsuzaa, F., Cochet, A., Darriet, Frédéric, Demantké, A., Elefant, E., Failloux, A.B., Gentile, L. de, Lagneau, C., La Ruche, G., Pecquet, C., Sorge, f., Tarantola, A., and Vauzelle, C.

Subjects
RECOMMANDATIONS, TOXICITE, VECTEUR, PREVENTION SANITAIRE, ACARIEN PREDATEUR, INSECTE, ENFANT, TIQUE, GROSSESSE, INSECTICIDE CHIMIQUE, EPIDEMIE, METHODE DE LUTTE, MOUSTIQUE, MOUSTIQUAIRE IMPREGNEE, MANUEL
Published
2010

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