1. Effect of spinal cord stimulation on regional myocardial perfusion assessed by positron emission tomography
- Author
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De Landsheere, Christian, Mannheimer, Clas, Habets, Alfons, Guillaume, Marcel, Bourgeois, Ivan, Augustinsson, Lars-Erik, Eliasson, Tore, Lamotte, Daniel, Kulbertus, Henri, and Rigo, Pierre
- Subjects
PET imaging ,Spinal cord -- Physiological aspects ,Electric stimulation -- Health aspects ,Perfusion (Physiology) -- Health aspects ,Angina pectoris -- Care and treatment ,Health - Abstract
Spinal cord stimulation (SCS) can relieve symptoms in patients with severe angina pectoris refractory to conventional medical or surgical therapy. This symptomatic improvement may result from decreased myocardial ischemia. To test this hypothesis, positron emission tomography (PET) and potassium-38 as a flow tracer were used in 8 patients for the quantitative evaluation of regional myocardial perfusion at rest and after exercise, before and during SCS. Potassium uptake was evaluated as myocardial clearance (flow times net extraction) in ml/min/100 g. Tomographic segments were categorized as nonaffected and affected on the basis of the absence or presence of arterial stenosis on coronary angiography and on the basis of thallium scintigraphic data. In nonaffected segments, before SCS, regional myocardial clearance significantly increased from rest (28 [+ or -] 4) to exercise (47 [+ or -] 13 clearance units; p
- Published
- 1992