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The study aimed to evaluate the toxic effects of fungicide Prosaro 250 EC on hematological profiles and renal functional-biochemical markers, as well as blood glucose level .Twenty-four male rabbits were equally and randomly divided into control untreated group (G1) (n =6) received distilled water and standard food, and three treated groups (n=6 each) received by oral gavage Prosaro 250 EC at three doses (mg/kg body weight (bw)), 0.093 (G2), 0.186 (G3) and 0.465 mg/kg bw (G4) for 21 days .Results revealed a significant decrease in the kidney weight, and a significant increase in the levels of serum urea, uric acid, creatinine, and glucose in Prosaro treated groups compared with the control group. Moreover, Prosaro-induced hematotoxicity was evidenced by a marked decline inred blood cell counts (RBC), hemoglobin (HGH) and hematocrit (HT) levels, along with a significant increase in white blood cell (WBC) and platelet count. Thus the sub-chronic toxicity of Prosaro 250 EC is proved to induce hematological and biochemical alterations in rabbits.

The impact of trace metal elements (TMEs) on plants is one current pollution problem, the severity of which is increasing with industrial development, population growth and inappropriate agricultural practices. The latter can have irreversible effects on ecosystems, including species extinction, trophic chain contamination and altered human health, particularly in the case of consumed plants such as zucchini squash (Cucurbita pepo L.). This study aims to investigate the effects of nickel on various physiological and biochemical parameters of zucchini growth, with a particular focus on how this toxic metal impacts the quality of fruit that is consumed by humans. To achieve this, plants aged 45 days were grown for one month on solid media loaded with different concentrations of Ni (0, 100, 300 and 500 µM). The results showed that exposure of plants to Ni resulted in significantly altered growth and higher accumulation of Ni in the shoots (1314 µg·g−1 DW) than in roots and fruits. Concerning non-enzymatic antioxidants, the results showed that Ni toxicity significantly increased total polyphenols, especially in shoots at 300 µM Ni, while flavonoid content decreased in the roots and shoots in response to Ni treatment. Our results also show that nickel tolerance in C. pepo is ensured by a combination of several mechanisms such as an increase in the content of proline. This species can survive and tolerate, to different degrees, toxic cations at concentrations up to 500 µM but with visible symptoms of toxicity such as chlorosis of the leaves. Indeed, based on thresholds of hyperaccumulation, we can qualify Cucurbita pepo as a hyperaccumulator species of nickel. [ABSTRACT FROM AUTHOR]