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3. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, and Kanneganti, Thirumala-Devi

Subjects
Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Generic health relevance, Good Health and Well Being, Animals, Humans, Apoptosis, Cell Death, Caspases, Carcinogenesis, Mammals, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

4. Diagnosis of prostate cancer with magnetic resonance imaging in men treated with 5-alpha-reductase inhibitors

Author

Falagario, Ugo G., Lantz, Anna, Jambor, Ivan, Busetto, Gian Maria, Bettocchi, Carlo, Finati, Marco, Ricapito, Anna, Luzzago, Stefano, Ferro, Matteo, Musi, Gennaro, Totaro, Angelo, Racioppi, Marco, Carbonara, Umberto, Checcucci, Enrico, Manfredi, Matteo, D’Aietti, Damiano, Porcaro, Antonio Benito, Nordström, Tobias, Björnebo, Lars, Oderda, Marco, Soria, Francesco, Taimen, Pekka, Aronen, Hannu J., Perez, Ileana Montoya, Ettala, Otto, Marchioni, Michele, Simone, Giuseppe, Ferriero, Mariaconsiglia, Brassetti, Aldo, Napolitano, Luigi, Carmignani, Luca, Signorini, Claudia, Conti, Andrea, Ludovico, Giuseppe, Scarcia, Marcello, Trombetta, Carlo, Claps, Francesco, Traunero, Fabio, Montanari, Emanuele, Boeri, Luca, Maggi, Martina, Del Giudice, Francesco, Bove, Pierluigi, Forte, Valerio, Ficarra, Vincenzo, Rossanese, Marta, Mucciardi, Giuseppe, Pagliarulo, Vincenzo, Tafuri, Alessandro, Mirone, Vincenzo, Schips, Luigi, Antonelli, Alessandro, Gontero, Paolo, Cormio, Luigi, Sciarra, Alessandro, Porpiglia, Francesco, Bassi, PierFrancesco, Ditonno, Pasquale, Boström, Peter J., Messina, Emanuele, Panebianco, Valeria, De Cobelli, Ottavio, and Carrieri, Giuseppe

Published
2023
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6. The role of warm ischemia time on functional outcomes after robotic partial nephrectomy: a radionuclide renal scan study from the clock randomized trial

Author

Antonelli, Alessan dro, Cindolo, Luca, Sandri, Marco, Veccia, Alessandro, Annino, Filippo, Bertagna, Francesco, Di Maida, Fabrizio, Celia, Antonio, D’Orta, Carlo, De Concilio, Bernardino, Furlan, Maria, Giommoni, Valentina, Ingrosso, Manuela, Mari, Andrea, Nucciotti, Roberto, Olianti, Catia, Porreca, Angelo, Primiceri, Giulia, Schips, Luigi, Sessa, Francesco, Bove, Pierluigi, Simeone, Claudio, and Minervini, Andrea

Published
2023
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7. Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

Author

Cocci, Andrea, Pezzoli, Marta, Bianco, Fernando, Blefari, Franco, Bove, Pierluigi, Cornud, Francois, De Rienzo, Gaetano, Destefanis, Paolo, Di Trapani, Danilo, Giacobbe, Alessandro, Giovanessi, Luca, Laganà, Antonino, Lughezzani, Giovanni, Manenti, Guglielmo, Muto, Gianluca, Patelli, Gianluigi, Pinzi, Novello, Regusci, Stefano, Russo, Giorgio I., Salamanca, Juan I.M., Salvi, Matteo, Silvestri, Luigi, Verweij, Fabrizio, Walser, Eric, Bertolo, Riccardo G., Iacovelli, Valerio, Bertaccini, Alessandro, Marchiori, Debora, Davila, Hugo, Ditonno, Pasquale, Gontero, Paolo, Iapicca, Gennaro, M De Reijke, Theo, Ricapito, Vito, Pellegrini, Pierluca, Minervini, Andrea, Serni, Sergio, and Sessa, Francesco

Published
2024
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8. Advanced Age Impacts Survival After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Author

Ferro, Matteo, Chiujdea, Sever, Vartolomei, Mihai Dorin, Bove, Pierluigi, Porreca, Angelo, Busetto, Gian Maria, del Giudice, Francesco, Antonelli, Alessandro, Foschi, Nazario, Racioppi, Marco, Autorino, Riccardo, Chiancone, Francesco, Longo, Nicola, Barone, Biagio, Crocetto, Felice, Musi, Gennaro, Luzzago, Stefano, Piccinelli, Mattia Luca, Mistretta, Francesco Alessandro, de Cobelli, Ottavio, Tataru, Octavian Sabin, Hurle, Rodolfo, Liguori, Giovanni, Borghesi, Marco, Veccia, Alessandro, Greco, Francesco, Schips, Luigi, Marchioni, Michele, Lucarelli, Giuseppe, Dutto, Daniele, Colucci, Fulvia, Russo, Giorgio Ivan, Giudice, Arturo Lo, Montanari, Emanuele, Boeri, Luca, Simone, Giuseppe, Rosazza, Matteo, Livoti, Simone, Gontero, Paolo, and Soria, Francesco

Published
2024
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9. Macrophage polarization and metabolism in atherosclerosis

Author

Hou, Pengbo, Fang, Jiankai, Liu, Zhanhong, Shi, Yufang, Agostini, Massimiliano, Bernassola, Francesca, Bove, Pierluigi, Candi, Eleonora, Rovella, Valentina, Sica, Giuseppe, Sun, Qiang, Wang, Ying, Scimeca, Manuel, Federici, Massimo, Mauriello, Alessandro, and Melino, Gerry

Published
2023
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11. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)

Author

Tafuri, Alessandro, Marchioni, Michele, Cerrato, Clara, Mari, Andrea, Tellini, Riccardo, Odorizzi, Katia, Veccia, Alessandro, Amparore, Daniele, Shakir, Aliasger, Carbonara, Umberto, Panunzio, Andrea, Trovato, Federica, Catellani, Michele, Janello, Letizia M. I., Bianchi, Lorenzo, Novara, Giacomo, Dal Moro, Fabrizio, Schiavina, Riccardo, De Lorenzis, Elisa, Parma, Paolo, Cimino, Sebastiano, De Cobelli, Ottavio, Maiorino, Francesco, Bove, Pierluigi, Crocerossa, Fabio, Cantiello, Francesco, D’Andrea, David, Di Cosmo, Federica, Porpiglia, Francesco, Ditonno, Pasquale, Montanari, Emanuele, Soria, Francesco, Gontero, Paolo, Liguori, Giovanni, Trombetta, Carlo, Mantica, Guglielmo, Borghesi, Marco, Terrone, Carlo, Del Giudice, Francesco, Sciarra, Alessandro, Galosi, Andrea, Moschini, Marco, Shariat, Shahrokh F., Di Nicola, Marta, Minervini, Andrea, Ferro, Matteo, Cerruto, Maria Angela, Schips, Luigi, Pagliarulo, Vincenzo, and Antonelli, Alessandro

Published
2022
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12. MP19-10 ADDITIONAL VALUE OF MRI IN PATIENTS WITH PSA >10 NG/ML AND/OR POSITIVE DRE: IS MRI ALWAYS NEEDED?

Author

Guzzi, Francesco, primary, Falagario, Ugo, additional, Lantz, Anna, additional, Carmignani, Luca, additional, Montanari, Emanuele, additional, Bove, Pierluigi, additional, Gontero, Paolo, additional, Porpiglia, Francesco, additional, Sciarra, Alessandro, additional, Trombetta, Carlo, additional, Bassi, Pierfrancesco, additional, Simone, Giuseppe, additional, Mirone, Vincenzo, additional, Antonelli, Alessandro, additional, Schips, Luigi, additional, Ludovico, Giuseppe, additional, Ricapito, Anna, additional, Busetto, Gian Maria, additional, Ficarra, Vincenzo, additional, Nordstrom, Tobias, additional, Bostrom, Peter, additional, De Cobelli, Ottavio, additional, Cormio, Luigi, additional, and Carrieri, Giuseppe, additional

Published
2024
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13. Minimally invasive transperitoneal partial versus radical nephrectomy in obese patients: perioperative and long-term functional outcomes from a large perspective contemporary series (RECORd2 project)

Author

LAMBERTINI, Luca, primary, MARI, Andrea, additional, SANDULLI, Alessandro, additional, AMPARORE, Daniele, additional, ANTONELLI, Alessandro, additional, BARALE, Maurizio, additional, BOVE, Pierluigi, additional, BRUNOCILLA, Eugenio, additional, CAPITANIO, Umberto, additional, DA POZZO, Luigi F., additional, DI MAIDA, Fabrizio, additional, GROSSO, Antonio Andrea, additional, FIORI, Cristian, additional, GONTERO, Paolo, additional, LI MARZI, Vincenzo, additional, CAMPI, Riccardo, additional, LONGO, Nicola, additional, MARCHIONI, Michele, additional, MONTANARI, Emanuele, additional, MONTORSI, Francesco, additional, PORPIGLIA, Francesco, additional, PORRECA, Angelo, additional, SCHIAVINA, Riccardo, additional, SIMEONE, Claudio, additional, SIRACUSANO, Salvatore, additional, TERRONE, Carlo, additional, FICARRA, Vincenzo, additional, and MINERVINI, Andrea, additional

Published
2024
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14. MP74-12 IMPACT OF MAGNETIC RESONANCE IMAGING SCAN AND IMAGE ACQUISITION PROTOCOL IN DETECTING CLINICALLY SIGNIFICANT PROSTATE CANCER AT BIOPSY: RESULTS FROM THE PROMOD WORKING GROUP

Author

Fanelli, Antonio, primary, Finati, Marco, additional, Falagario, Ugo Giovanni, additional, Lantz, Anna, additional, Jambor, Ivan, additional, Carmignani, Luca, additional, Montanari, Emanuele, additional, Bove, Pierluigi, additional, Gontero, Paolo, additional, Sciarra, Alessandro, additional, Trombetta, Carlo, additional, Bassi, Pierfrancesco, additional, Simone, Giuseppe, additional, Mirone, Vincenzo, additional, Antonelli, Alessandro, additional, Schips, Luigi, additional, Busetto, Gian Maria, additional, Bettocchi, Carlo, additional, Ferro, Mattero, additional, Bostrom, Peter, additional, Nordstrom, Tobias, additional, De Cobelli, Ottavio, additional, Cormio, Luigi, additional, and Carrieri, Giuseppe, additional

Published
2024
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15. PD19-08 EAU RISK STRATIFICATION FOR PROSTATE CANCER ACCORDING TO SYSTEMATIC BIOPSY, TARGET BIOPSY AND COMBINED BIOPSY RESULTS AND FINAL PATHOLOGY CONCORDANCE. RESULTS FROM THE PROMOD STUDY GROUP

Author

Ninivaggi, Antonella, primary, Falagario, Ugo Giovanni, additional, Cormio, Angelo, additional, Galosi, Andrea Benedetto, additional, Carmignani, Luca, additional, Montanari, Emanuele, additional, Bove, Pierluigi, additional, Gontero, Paolo, additional, Porpiglia, Francesco, additional, Sciarra, Alessandro, additional, Trombetta, Carlo, additional, Bassi, Pierfrancesco, additional, Simone, Giuseppe, additional, Ludovico, Giuseppe, additional, Mirone, Vincenzo, additional, Antonelli, Alessandro, additional, Schips, Luigi, additional, Ricapito, Anna, additional, Busetto, Gian Maria, additional, Ficarra, Vincenzo, additional, Boström, Peter J., additional, De Cobelli, Ottavio, additional, Cormio, Luigi, additional, and Carrieri, Giuseppe, additional

Published
2024
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16. MP49-13 INTERCENTER VARIABILITY IN THE ACCURACY OF RISK CALCULATORS BASED ON MRI PARAMETERS: EXTENSIVE EXTERNAL VALIDATION OF 7 CONTEMPORARY RISK CALCULATORS

Author

Tocci, Edoardo, primary, Falagario, Ugo, additional, Lantz, Anna, additional, Jambor, Ivan, additional, Busetto, Gian Maria, additional, Bettocchi, Carlo, additional, Cormio, Luigi, additional, Nordstrom, Tobias, additional, Schips, Luigi, additional, Gontero, Paolo, additional, Carmignani, Luca, additional, Bove, Pierluigi, additional, Montanari, Emanuele, additional, Trombetta, Carlo, additional, Simone, Giuseppe, additional, Ficarra, Vincenzo, additional, Ludovico, Giuseppe, additional, Mirone, Vincenzo, additional, Antonelli, Alessandro, additional, Porpiglia, Francesco, additional, Bassi, Pierfrancesco, additional, Bostrom, Peter J., additional, De Cobelli, Ottavio, additional, and Carrieri, Giuseppe, additional

Published
2024
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17. Randomized Clinical Trial Comparing On-clamp Versus Off-clamp Laparoscopic Partial Nephrectomy for Small Renal Masses (CLOCK II Laparoscopic Study): A Intention-to-treat Analysis of Perioperative Outcomes

Author

Bertolo, Riccardo, Bove, Pierluigi, Sandri, Marco, Celia, Antonio, Cindolo, Luca, Cipriani, Chiara, Falsaperla, Mario, Leonardo, Costantino, Mari, Andrea, Parma, Paolo, Veccia, Alessandro, Veneziano, Domenico, Minervini, Andrea, and Antonelli, Alessandro

Published
2022
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18. The Intraoperative Complications Assessment and Reporting with Universal Standards (ICARUS) Global Surgical Collaboration Project: Development of Criteria for Reporting Adverse Events During Surgical Procedures and Evaluating Their Impact on the Postoperative Course

Author

Cacciamani, Giovanni E., Sholklapper, Tamir, Dell'Oglio, Paolo, Rocco, Bernardo, Annino, Filippo, Antonelli, Alessandro, Amenta, Michele, Borghesi, Marco, Bove, Pierluigi, Bozzini, Giorgio, Cafarelli, Angelo, Celia, Antonio, Leonardo, Costantino, Ceruti, Carlo, Cindolo, Luca, Crivellaro, Simone, Dalpiaz, Orietta, Falabella, Roberto, Falsaperla, Mario, Galfano, Antonio, Gallo, Farizio, Greco, Francesco, Minervini, Andrea, Parma, Paolo, Chiara Sighinolfi, Maria, Pastore, Antonio L., Pini, Giovannalberto, Porreca, Angelo, Pucci, Luigi, Sciorio, Carmine, Schiavina, Riccardo, Umari, Paolo, Varca, Virginia, Veneziano, Domenico, Verze, Paolo, Volpe, Alessandro, Zaramella, Stefano, Lebastchi, Amir, Abreu, Andre, Mitropoulos, Dionysios, Shekhar Biyani, Chandra, Sotelo, Rene, Desai, Mihir, Artibani, Walter, and Gill, Inderbir

Published
2022
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19. The efficacy of a suppository based on Phenolmicin P3 and Bosexil (Mictalase®) in control of irritative symptoms in patients undergoing thulium laser enucleation of prostate: a single-center, randomized, controlled, open label, phase III study

Author

Bertolo, Riccardo, Cipriani, Chiara, Vittori, Matteo, Carilli, Marco, Maiorino, Francesco, Iacovelli, Valerio, Ganini, Carlo, Antonucci, Michele, Signoretti, Marta, Petta, Filomena, Panei, Massimo, and Bove, Pierluigi

Published
2022
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20. Transperineal Laser Ablation for Focal Therapy of Localized Prostate Cancer: 12-Month Follow-up Outcomes from a Single Prospective Cohort Study.

Author

Iacovelli, Valerio, Carilli, Marco, Bertolo, Riccardo, Forte, Valerio, Vittori, Matteo, Filippi, Beatrice, Di Giovanni, Giulia, Cipriani, Chiara, Petta, Filomena, Maiorino, Francesco, Signoretti, Marta, Antonucci, Michele, Guidotti, Alessio, Travaglia, Stefano, Caputo, Francesco, Manenti, Guglielmo, and Bove, Pierluigi

Subjects
PROSTATE tumors treatment, BIOPSY, POSTOPERATIVE care, ABLATION techniques, CANCER relapse, VISUAL analog scale, TREATMENT effectiveness, MAGNETIC resonance imaging, DESCRIPTIVE statistics, LASER therapy, SURGICAL complications, PATIENT aftercare
Abstract

Simple Summary: Prostate cancer is the second most diagnosed cancer in men. Focal laser ablation has been proposed as an alternative to radical treatments in carefully selected patients in order to achieve long-term cancer control and reduce the morbidity associated with surgery and radiation therapy. This study aimed to evaluate the oncological and functional outcomes of transperineal laser ablation (TPLA) as the focal therapy for localized prostate cancer. We assessed that TPLA is a safe, painless, and effective technique with good oncological results and the preservation of continence and sexual outcomes. Introduction and objectives: To evaluate the oncological and functional outcomes of transperineal laser ablation (TPLA) as the focal therapy for localized prostate cancer (PCa) after a 12-month follow-up. Materials and methods: Patients with low- and intermediate-risk localized PCa were prospectively treated with focal TPLA between July 2021 and December 2022. The inclusion criteria were the following: clinical stage < T2b; PSA < 20 ng/mL; International Society of Urological Pathology (ISUP) grade ≤ 2; MRI-fusion biopsy-confirmed lesion classified as PI-RADS v2.1 ≥ 3. Intra-, peri-, and post-operative data were collected. Variables including age, PSA, prostate volume (PVol), Charlson's Comorbidity Index (CCI), International Prostate Symptom Score (IPSS) with QoL score, International Index of Erectile Function (IIEF-5), International Consultation on Incontinence Questionnaire—Short Form (ICIQ-SF), and Male Sexual Health Questionnaire—Ejaculatory Dysfunction Short Form (MSHQ-EjD) were collected at baseline and at 3, 6 and 12 months after TPLA. Post-operative mpMRI was performed at 3 and 12 months. Finally, all patients underwent prostatic re-biopsy under fusion guidance at 12 months. The success of this technique was defined as no recurrence in the target treated lesion at the 12-month follow up. Results: Twenty-four patients underwent focal TPLA. Baseline features were age [median 67 years (IQR 12)], PSA [5.7 ng/mL (3.9)], PVol [49 mL (27)], CCI [0 (0)], IPSS [11 (9)], IPSS-QoL [2 (2)], IIEF-5 [21 (6)], ICIQ-SF [0 (7)], MSHQ-EjD ejaculation domain [14 (4)] and bother score [0 (2)]. Median operative time was 34 min (IQR 12). Median visual analogue scale (VAS) 6 h after TPLA was 0 (IQR 1). The post-operative course was regular for all patients, who were discharged on the second post-operative day and underwent catheter removal on the seventh post-operative day. No patient had incontinence at catheter removal. A significant reduction in PSA (p = 0.01) and an improvement in IPSS (p = 0.009), IPSS-QoL (p = 0.02) and ICIQ-SF scores (p = 0.04) compared to baseline were observed at the 3-month follow-up. Erectile and ejaculatory functions did not show any significant variation during the follow-up. No intra- and peri-operative complications were recorded. Three Clavien–Dindo post-operative complications were recorded (12%): grade 1 (two cases of urinary retention) and grade 2 (one case of urinary tract infection). At the 12-month follow-up, eight patients showed mpMRI images referable to suspicious recurrent disease (PIRADS v2.1 ≥ 3). After re-biopsy, 7/24 patients' (29%) results were histologically confirmed as PCa, 3 of which were recurrences in the treated lesion (12.5%). The success rate was 87.5%. Conclusions: The focal TPLA oncological and functional results seemed to be encouraging. TPLA is a safe, painless, and effective technique with a good preservation of continence and sexual outcomes. Recurrence rate at 12 months was about 12.5%. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Time to progression is the main predictor of survival in patients with high-risk nonmuscle invasive bladder cancer: Results from a machine learning-based analysis of a large multi-institutional database

Author

Porreca, Annamaria, Di Nicola, Marta, Lucarelli, Giuseppe, Dorin, Vartolomei Mihai, Soria, Francesco, Terracciano, Daniela, Mistretta, Francesco Alessandro, Luzzago, Stefano, Buonerba, Carlo, Cantiello, Francesco, Mari, Andrea, Minervini, Andrea, Veccia, Alessandro, Antonelli, Alessandro, Musi, Gennaro, Hurle, Rodolfo, Busetto, Gian Maria, Del Giudice, Francesco, Ferretti, Simone, Perdonà, Sisto, Prete, Paola Del, Porreca, Angelo, Bove, Pierluigi, Crisan, Nicolae, Russo, Giorgio Ivan, Damiano, Rocco, Amparore, Daniele, Porpiglia, Francesco, Autorino, Riccardo, Piccinelli, Mattia, Brescia, Antonio, Tătaru, Sabin Octavian, Crocetto, Felice, Giudice, Arturo Lo, de Cobelli, Ottavio, Schips, Luigi, Ferro, Matteo, and Marchioni, Michele

Published
2024
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24. Open versus Robot-Assisted Radical Cystectomy for the Treatment of pT4a Bladder Cancer: Comparison of Perioperative Outcomes

Author

Perri, Davide, primary, Rocco, Bernardo, additional, Sighinolfi, Maria Chiara, additional, Bove, Pierluigi, additional, Pastore, Antonio L., additional, Volpe, Alessandro, additional, Minervini, Andrea, additional, Antonelli, Alessandro, additional, Zaramella, Stefano, additional, Galfano, Antonio, additional, Cacciamani, Giovanni E., additional, Celia, Antonio, additional, Dalpiaz, Orietta, additional, Crivellaro, Simone, additional, Greco, Francesco, additional, Pini, Giovannalberto, additional, Porreca, Angelo, additional, Pacchetti, Andrea, additional, Calcagnile, Tommaso, additional, Berti, Lorenzo, additional, Buizza, Carlo, additional, Mazzoleni, Federica, additional, and Bozzini, Giorgio, additional

Published
2024
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25. Rotterdam mobile phone app including MRI data for the prediction of prostate cancer: A multicenter external validation

Author

De Nunzio, Cosimo, Lombardo, Riccardo, Baldassarri, Valeria, Cindolo, Luca, Bertolo, Riccardo, Minervini, Andrea, Sessa, Francesco, Muto, Gianluca, Bove, Pierluigi, Vittori, Matteo, Bozzini, Giorgio, Castellan, Pietro, Mugavero, Filippo, Falsaperla, Mario, Schips, Luigi, Celia, Antonio, Bada, Maida, Porreca, Angelo, Pastore, Antonio, Al Salhi, Yazan, Giampaoli, Marco, Novella, Giovanni, Rizzetto, Riccardo, Trabacchin, Nicolo, Mantica, Guglielmo, Pini, Giovannalberto, Remmers, Sebastiaan, Antonelli, Alessandro, and Tubaro, Andrea

Published
2021
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26. Toward Individualized Approaches to Partial Nephrectomy: Assessing the Correlation Between Ischemia Time and Patient Health Status (RECORD2 Project)

Author

Bravi, Carlo Andrea, Mari, Andrea, Larcher, Alessandro, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Bertini, Roberto, Bove, Pierluigi, Brunocilla, Eugenio, Da Pozzo, Luigi, di Maida, Fabrizio, Fiori, Cristian, Gallioli, Andrea, Gontero, Paolo, Li Marzi, Vincenzo, Longo, Nicola, Mirone, Vincenzo, Porpiglia, Francesco, Rocco, Bernardo, Schiavina, Riccardo, Schips, Luigi, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Terrone, Carlo, Trombetta, Carlo, Ficarra, Vincenzo, Carini, Marco, Montorsi, Francesco, Capitanio, Umberto, and Minervini, Andrea

Published
2021
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27. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, Carlo Andrea, Larcher, Alessandro, Capitanio, Umberto, Mari, Andrea, Antonelli, Alessandro, Artibani, Walter, Barale, Maurizio, Bertini, Roberto, Bove, Pierluigi, Brunocilla, Eugenio, Da Pozzo, Luigi, Di Maida, Fabrizio, Fiori, Cristian, Gontero, Paolo, Li Marzi, Vincenzo, Longo, Nicola, Mirone, Vincenzo, Montanari, Emanuele, Porpiglia, Francesco, Schiavina, Riccardo, Schips, Luigi, Simeone, Claudio, Siracusano, Salvatore, Terrone, Carlo, Trombetta, Carlo, Volpe, Alessandro, Montorsi, Francesco, Ficarra, Vincenzo, Carini, Marco, and Minervini, Andrea

Published
2021
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30. Predicting positive surgical margins in partial nephrectomy: A prospective multicentre observational study (the RECORd 2 project)

Author

Altieri, Vincenzo, Berardinelli, Francesco, Borghesi, Marco, Bravi, Carlo Andrea, Bove, Pierluigi, Cacciamani, Giovanni Enrico, Campi, Riccardo, Celia, Antonio, Costantini, Elisabetta, Da Pozzo, Luigi, Falsaperla, Mario, Ferro, Matteo, Furlan, Maria, Sforza, Simone, Marson, Francesco, Montorsi, Francesco, Nazzani, Sebastiano, Porreca, Angelo, Russo, Giorgio Ivan, Schips, Luigi, Selli, Cesare, Simonato, Alchiede, Siracusano, Salvatore, Trombetta, Carlo, Schiavina, Riccardo, Mari, Andrea, Bianchi, Lorenzo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Brunocilla, Eugenio, Capitanio, Umberto, Fiori, Cristian, Di Maida, Fabrizio, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Marra, Giancarlo, Montanari, Emanuele, Porpiglia, Francesco, Roscigno, Marco, Simeone, Claudio, Tellini, Riccardo, Terrone, Carlo, Villari, Donata, Ficarra, Vincenzo, Carini, Marco, and Minervini, Andrea

Published
2020
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31. The role of vacuum-assisted closure (VAC) therapy in the management of FOURNIER’S gangrene: a retrospective multi-institutional cohort study

Author

Iacovelli, Valerio, Cipriani, Chiara, Sandri, Marco, Filippone, Roberta, Ferracci, Antonella, Micali, Salvatore, Rocco, Bernardo, Puliatti, Stefano, Ferrarese, Paolo, Benedetto, Giuseppe, Minervini, Andrea, Cocci, Andrea, Pastore, Antonio Luigi, Al Salhi, Yazan, Antonelli, Alessandro, Morena, Tonino, Volpe, Alessandro, Poletti, Filippo, Celia, Antonio, Zeccolini, Guglielmo, Leonardo, Costantino, Proietti, Flavia, Finazzi Agrò, Enrico, and Bove, Pierluigi

Published
2021
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34. Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study

Author

Vittori, Matteo, Bove, Pierluigi, Signoretti, Marta, Cipriani, Chiara, Gasparoli, Cristiano, Antonucci, Michele, Carilli, Marco, Maiorino, Francesco, Iacovelli, Valerio, Petta, Filomena, Travaglia, Stefano, Panei, Massimo, Russo, Pierluigi, and Bertolo, Riccardo

Abstract

Introduction: Crystalluria is an important indicator of renal stone recurrence. Mechanisms underlying urinary stone formation are still not fully understood and raising interests has been giving to intestinal commensal bacteria for their contribute in maintaining urinary solutes equilibrium. The aim of our phase II study was to examine the administration of potassium citrate, magnesium and probiotics in order to reduce crystalluria.Materials and Methods: Since May 2021, we enrolled 23 patients candidates for ureterorenolithotripsy for calcium oxalate kidney stones with crystalluria and a normal metabolic profile. The analysis was validated by the Institution’s Ethical Committee (no. approval STS CE Lazio 1/N-823). At discharge, patients were provided with daily food supplementation for 20 days of 1 billion Lactobacillus paracasei LPC09, 1 billion Lactobacillus plantarum LP01, 1 billion Bifidobacterium breve BR03, potassium (520 mg), citrate (1400 mg), and magnesium (80 mg). Crystalluria was re-assessed at 1, 3, 6, and 12-months follow-up by polarized light microscopy.Results: After one month from the oral supplementation, no patient reported crystalluria; at 3 months, among the 20 participants available for re-evaluation, still no patient reported crystalluria. Instead, crystalluria was reported in three patients (15%) at 6 months, and in five patients (25%) at 12 months follow-up.Conclusions: The oral supplementation with Lactobacillus spp. and Bifidobacterium spp. was found able to reduce the prevalence of crystalluria in a cohort of patients with diagnosis of calcium oxalate kidney stones with crystalluria candidate to ureterorenolithotripsy.

Published
2024
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35. External validation of Cormio nomogram for predicting all prostate cancers and clinically significant prostate cancers

Author

Cindolo, Luca, Bertolo, Riccardo, Minervini, Andrea, Sessa, Francesco, Muto, Gianluca, Bove, Pierluigi, Vittori, Matteo, Bozzini, Giorgio, Castellan, Pietro, Mugavero, Filippo, Falsaperla, Mario, Schips, Luigi, Celia, Antonio, Bada, Maida, Porreca, Angelo, Pastore, Antonio, Al Salhi, Yazan, Giampaoli, Marco, Novella, Giovanni, Rizzetto, Riccardo, Trabacchin, Nicoló, Mantica, Guglielmo, Pini, Giovannalberto, Lombardo, Riccardo, Tubaro, Andrea, Antonelli, Alessandro, and De Nunzio, Cosimo

Published
2020
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37. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. Marie [0000-0002-4847-2045], Haupt, Ygal [0000-0001-5925-0096], He, Sudan [0000-0002-0846-1210], Heery, David M. [0000-0002-5035-2392], Hengartner, Michael O. [0000-0002-7584-596X], Hetz, Claudio [0000-0003-1120-7966], Hildeman, David A. [0000-0002-0421-8483], Ichijo, Hidenori [0000-0002-5005-6438], Jäättelä, Marja [0000-0001-5950-7111], Janic, Ana [0000-0002-4200-2560], Joseph, Bertrand [0000-0001-5655-9979], Jost, Philipp J. [0000-0003-2454-0362], Kanneganti, Thirumala-Devi [0000-0002-6395-6443], Karin, Michael [0000-0002-2758-6473], Kashkar, Hamid [0000-0003-2796-1429], Kaufmann, Thomas [0000-0001-9906-874X], Kelly, Gemma L. [0000-0002-6533-1201], Kepp, Oliver [0000-0002-6081-9558], Kimchi, Adi [0000-0002-8236-8989], Klionsky, Daniel J. [0000-0002-7828-8118], Kluck, Ruth [0000-0002-7101-1925], Krysko, Dmitri V. [0000-0002-9692-2047], Kulms, Dagmar [0000-0001-6874-0548], Kumar, Sharad [0000-0001-7126-9814], Lavandero, Sergio [0000-0003-4258-1483], Lavrik, Inna N. [0000-0002-9324-309X], Liccardi, Gianmaria [0000-0002-2662-1281], Linkermann, Andreas [0000-0001-6287-9725], Lipton, Stuart A. [0000-0002-3490-1259], Lockshin, Richard A. [0000-0002-4389-4898], López-Otín, Carlos [0000-0001-6964-1904], Luedde, Tom [0000-0002-6288-8821], MacFarlane, Marion [0000-0001-7886-1159], Madeo, Frank [0000-0002-5070-1329], Malorni, Walter [0000-0002-1223-7000], Manic, Gwenola [0000-0003-3759-8029], Marchi, Saverio [0000-0003-2708-1843], Marine, Jean-Christophe [0000-0003-2433-9837], Martin, Seamus J. [0000-0002-8539-3143], Martinou, Jean-Claude [0000-0002-9847-2051], Mastroberardino, Pier G. [0000-0003-2364-4258], Medema, Jan Paul [0000-0003-3045-2924], Mehlen, Patrick [0000-0003-1743-5417], Meier, Pascal [0000-0003-2760-6523], Melino, Gerry [0000-0001-9428-5972], Melino, Sonia [0000-0001-7694-5279], Miao, Edward A. [0000-0001-7295-3490], Moll, Ute M. [0000-0003-1908-7516], Muñoz-Pinedo, Cristina [0000-0002-9120-664X], Murphy, Daniel J. [0000-0002-5538-5468], Niklison-Chirou, Maria Victoria [0000-0002-2147-370X], Novelli, Flavia [0000-0002-3746-7478], Oberst, Andrew [0000-0002-9500-7912], Ofengeim, Dimitry [0000-0003-2348-3642], Opferman, Joseph T. [0000-0002-1147-5621], Oren, Moshe [0000-0003-4311-7172], Pagano, Michele [0000-0003-3210-2442], Panaretakis, Theocharis [0000-0001-5754-6950], Pasparakis, Manolis [0000-0002-9870-0966], Penninger, Josef M. [0000-0002-8194-3777], Pentimalli, Francesca [0000-0003-4740-6801], Pereira, David M. [0000-0003-0384-7592], Pervaiz, Shazib [0000-0002-4738-019X], Peter, Marcus E. [0000-0003-3216-036X], Pinton, Paolo [0000-0001-7108-6508], Porta, Giovanni [0000-0001-5260-2415], Puthalakath, Hamsa [0000-0001-5178-1175], Rabinovich, Gabriel A. [0000-0002-0947-8735], Rajalingam, Krishnaraj [0000-0002-4175-9633], Ravinchandran, Kodi S. [0000-0001-9049-1410], Rehm, Markus [0000-0001-6149-9261], Ricci, Jean-Ehrland [0000-0003-1585-8117], Rizzuto, Rosario [0000-0001-7044-5097], Robinson, Nirmal [0000-0002-7361-9491], Rotblat, Barak [0000-0003-2985-7115], Rothlin, Carla V. [0000-0002-5693-5572], Rubinsztein, David C. [0000-0001-5002-5263], Rufini, Alessandro [0000-0002-5855-655X], Ryan, Kevin M. [0000-0002-1059-9681], Sarosiek, Kristopher A. [0000-0002-4618-5085], Sawa, Akira [0000-0003-1401-3008], Sayan, Emre [0000-0002-5291-1485], Schroder, Kate [0000-0001-9261-3805], Scorrano, Luca [0000-0002-8515-8928], Sesti, Federico [0000-0002-2761-9693], Shi, Yufang [0000-0001-8964-319X], Sica, Giuseppe [0000-0002-7407-0584], Silke, John [0000-0002-7611-5774], Simon, Hans-Uwe [0000-0002-9404-7736], Sistigu, Antonella [0000-0002-2528-1238], Stockwell, Brent R. [0000-0002-3532-3868], Strappazzon, Flavie [0000-0003-0285-7449], Sun, Liming [0000-0002-0136-5605], Sun, Erwei [0000-0001-5664-513X], Szabadkai, G [0000-0002-3006-3577], Tait, Stephen W. G. [0000-0001-7697-132X], Tang, Daolin [0000-0002-1903-6180], Tavernarakis, Nektarios [0000-0002-5253-1466], Turk, Boris [0000-0002-9007-5764], Urbano, Nicoletta [0000-0003-1822-155X], Vandenabeele, Peter [0000-0002-6669-8822], Vanden Berghe, Tom [0000-0002-1633-0974], Vander Heiden, Matthew G. [0000-0002-6702-4192], Vanderluit, Jacqueline L. [0000-0002-4960-920X], Verkhratsky, A. [0000-0003-2592-9898], Villunger, Andreas [0000-0001-8259-4153], Von Karstedt, Silvia [0000-0002-7816-5919], Voss, Anne K. [0000-0002-3853-9381], Vucic, Domagoj [0000-0003-3614-8093], Vuri, Daniela [0000-0001-8693-3845], Wagner, Erwin F. [0000-0001-7872-0196], Walczak, Henning [0000-0002-6312-4591], Wallach, David [0000-0003-2724-9757], Wang, Ruoning [0000-0001-9798-8032], Weber, Achim [0000-0003-0073-3637], Yamazaki, Takahiro [0000-0002-7420-4394], Zakeri, Zahra [0000-0003-4386-8072], Zawacka-Pankau, Joanna E. [0000-0002-7415-2942], Zhivotovsky, Boris [0000-0002-2238-3482], Piacentini, Mauro [0000-0003-2919-1296], Kroemer, Guido [0000-0002-9334-4405], Galluzzi, Lorenzo [0000-0003-2257-8500 ], Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Dieter, Adam, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco Emilio, Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo, Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. Marie [0000-0002-4847-2045], Haupt, Ygal [0000-0001-5925-0096], He, Sudan [0000-0002-0846-1210], Heery, David M. 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[0000-0002-3490-1259], Lockshin, Richard A. [0000-0002-4389-4898], López-Otín, Carlos [0000-0001-6964-1904], Luedde, Tom [0000-0002-6288-8821], MacFarlane, Marion [0000-0001-7886-1159], Madeo, Frank [0000-0002-5070-1329], Malorni, Walter [0000-0002-1223-7000], Manic, Gwenola [0000-0003-3759-8029], Marchi, Saverio [0000-0003-2708-1843], Marine, Jean-Christophe [0000-0003-2433-9837], Martin, Seamus J. [0000-0002-8539-3143], Martinou, Jean-Claude [0000-0002-9847-2051], Mastroberardino, Pier G. [0000-0003-2364-4258], Medema, Jan Paul [0000-0003-3045-2924], Mehlen, Patrick [0000-0003-1743-5417], Meier, Pascal [0000-0003-2760-6523], Melino, Gerry [0000-0001-9428-5972], Melino, Sonia [0000-0001-7694-5279], Miao, Edward A. [0000-0001-7295-3490], Moll, Ute M. [0000-0003-1908-7516], Muñoz-Pinedo, Cristina [0000-0002-9120-664X], Murphy, Daniel J. 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Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

39. Partial versus radical nephrectomy in very elderly patients: a propensity score analysis of surgical, functional and oncologic outcomes (RESURGE project)

Author

Mir, Maria C., Pavan, Nicola, Capitanio, Umberto, Antonelli, Alessandro, Derweesh, Ithaar, Rodriguez-Faba, Oscar, Linares, Estefania, Takagi, Toshio, Rha, Koon H., Fiori, Christian, Maurer, Tobias, Zang, Chao, Mottrie, Alexandre, Umari, Paolo, Long, Jean-Alexandre, Fiard, Gaelle, De Nunzio, Cosimo, Tubaro, Andrea, Tracey, Andrew T., Ferro, Matteo, De Cobelli, Ottavio, Micali, Salvatore, Bevilacqua, Luigi, Torres, João, Schips, Luigi, Castellucci, Roberto, Dobbs, Ryan, Quarto, Giuseppe, Bove, Pierluigi, Celia, Antonio, De Concilio, Bernardino, Trombetta, Carlo, Silvestri, Tommaso, Larcher, Alessandro, Montorsi, Francesco, Palumbo, Carlotta, Furlan, Maria, Bindayi, Ahmet, Hamilton, Zachary, Breda, Alberto, Palou, Joan, Aguilera, Alfredo, Tanabe, Kazunari, Raheem, Ali, Amiel, Thomas, Yang, Bo, Lima, Estevão, Crivellaro, Simone, Perdona, Sisto, Gregorio, Caterina, Barbati, Giulia, Porpiglia, Francesco, and Autorino, Riccardo

Published
2020
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41. Validation of Neutrophil-to-lymphocyte Ratio in a Multi-institutional Cohort of Patients With T1G3 Non–muscle-invasive Bladder Cancer

Author

Vartolomei, Mihai Dorin, Ferro, Matteo, Cantiello, Francesco, Lucarelli, Giuseppe, Di Stasi, Savino, Hurle, Rodolfo, Guazzoni, Giorgio, Busetto, Gian Maria, De Berardinis, Ettore, Damiano, Rocco, Perdona, Sisto, Verze, Paolo, La Rocca, Roberto, Borghesi, Marco, Schiavina, Riccardo, Brunocilla, Eugenio, Almeida, Gilberto L., Bove, Pierluigi, Lima, Estevao, Grimaldi, Giovanni, Autorino, Riccardo, Crisan, Nicolae, Abu Farhan, Abdal Rahman, Battaglia, Michele, Serretta, Vincenzo, Russo, Giorgio Ivan, Morgia, Giuseppe, Terracciano, Daniela, Musi, Gennaro, de Cobelli, Ottavio, Mirone, Vincenzo, and Shariat, Shahrokh F.

Published
2018
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42. Thulium laser transurethral incision of the prostate with ejaculation-sparing intent: 2-year follow-up outcomes from a high-volume centre.

Author

Carilli, Marco, Bertolo, Riccardo, Vittori, Matteo, Iacovelli, Valerio, Antonucci, Michele, Maiorino, Francesco, Signoretti, Marta, Petta, Filomena, and Bove, Pierluigi

Subjects
TRANSURETHRAL prostatectomy, THULIUM, PROSTATE, LASERS, SURGICAL indications, EJACULATION
Abstract

Introduction Several ‘ultra-minimally-invasive’ surgical treatments (uMISTs) have been developed, aiming to relieve benign prostatic obstruction (BPO) and spare ejaculatory function; however, such techniques do not always ensure substantial improvements in uroflowmetry parameters. The aim of the present study was to evaluate the 2-year functional outcomes of thulium laser transurethral incision of the prostate (ThuIP) as an alternative to uMISTs. Material and methods Data of consecutive patients affected by BPO with indication to surgical intervention and a strong will to spare ejaculatory function were collected on a dedicated prospectively maintained database. A specific “trifecta” was identified as the contemporary presence of: (1) post-operative Qmax ≥15 ml/s; (2) absence of early (within 90 days) complications; and (3) preserved antegrade ejaculation. Results 120 patients underwent ThuIP and were analysed. Median catheterisation time was 2 days (IQR 2-2). Significant improvements in IPSS and IPSS-QoL scores and uroflowmetry parameters were observed at all follow-up times. At the last follow-up visit (24 months) the median ΔIPSS was -12 (-17; -9), median ΔIPSS-QoL was -3 (-4; -2), median ΔQmax was +7.7 ml/s (+5.2; +11.0), and median ΔPVR was -50 ml (-100; 0) (all p-values <0.001). Fourteen patients reported postoperative absence of antegrade ejaculation (11.7%). Overall, trifecta was achieved in 86 patients (71.7%) at 6 months, in 79 patients (65.8%) at 12 months, and in 75 patients (62.5%) at 24 months. Conclusions ThuIP allows for a significant improvement in uroflowmetry parameters and patient-reported outcomes at 2-year follow-up. Moreover, antegrade ejaculation is preserved in approximately 90% of cases. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Advanced Age Impacts Survival After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Author

Ferro, Matteo, primary, Chiujdea, Sever, additional, Vartolomei, Mihai Dorin, additional, Bove, Pierluigi, additional, Porreca, Angelo, additional, Busetto, Gian Maria, additional, del Giudice, Francesco, additional, Antonelli, Alessandro, additional, Foschi, Nazario, additional, Racioppi, Marco, additional, Autorino, Riccardo, additional, Chiancone, Francesco, additional, Longo, Nicola, additional, Barone, Biagio, additional, Crocetto, Felice, additional, Musi, Gennaro, additional, Luzzago, Stefano, additional, Piccinelli, Mattia Luca, additional, Mistretta, Francesco Alessandro, additional, de Cobelli, Ottavio, additional, Tataru, Octavian Sabin, additional, Hurle, Rodolfo, additional, Liguori, Giovanni, additional, Borghesi, Marco, additional, Veccia, Alessandro, additional, Greco, Francesco, additional, Schips, Luigi, additional, Marchioni, Michele, additional, Lucarelli, Giuseppe, additional, Dutto, Daniele, additional, Colucci, Fulvia, additional, Russo, Giorgio Ivan, additional, Giudice, Arturo Lo, additional, Montanari, Emanuele, additional, Boeri, Luca, additional, Simone, Giuseppe, additional, Rosazza, Matteo, additional, Livoti, Simone, additional, Gontero, Paolo, additional, and Soria, Francesco, additional

Published
2023
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45. 65 - Early continence recovery after robot-assisted radical prostatectomy: A multicenter analysis on the role of prostatic shape

Author

Iacovelli, Valerio, Carilli, Marco, Sandri, Marco, Forte, Valerio, Antonelli, Alessandro, Celia, Antonio, Falabella, Roberto, Leonardo, Costantino, Minervini, Andrea, Pastore, Antonio Luigi, Patruno, Giulio, Secco, Silvia, Verze, Paolo, Bertolo, Riccardo, Vittori, Matteo, Petta, Filomena, Signoretti, Marta, Cipriani, Chiara, Finazzi Agrò, Enrico, and Bove, Pierluigi

Published
2024
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48. Systemic Inflammatory Markers and Oncologic Outcomes in Patients with High-risk Non–muscle-invasive Urothelial Bladder Cancer

Author

Cantiello, Francesco, Russo, Giorgio I., Vartolomei, Mihai Dorin, Farhan, Abdal Rahman Abu, Terracciano, Daniela, Musi, Gennaro, Lucarelli, Giuseppe, Di Stasi, Savino M., Hurle, Rodolfo, Serretta, Vincenzo, Busetto, Gian Maria, Scafuro, Chiara, Perdonà, Sisto, Borghesi, Marco, Schiavina, Riccardo, Cioffi, Antonio, De Berardinis, Ettore, Almeida, Gilberto L., Bove, Pierluigi, Lima, Estevao, Ucciero, Giuseppe, Matei, Deliu Victor, Crisan, Nicolae, Verze, Paolo, Battaglia, Michele, Guazzoni, Giorgio, Autorino, Riccardo, Morgia, Giuseppe, Damiano, Rocco, de Cobelli, Ottavio, Mirone, Vincenzo, Shariat, Shahrokh F., and Ferro, Matteo

Published
2018
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49. An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer

Author

Ferro, Matteo, Vartolomei, Mihai Dorin, Russo, Giorgio Ivan, Cantiello, Francesco, Farhan, Abdal Rahman Abu, Terracciano, Daniela, Cimmino, Amelia, Di Stasi, Savino, Musi, Gennaro, Hurle, Rodolfo, Serretta, Vincenzo, Busetto, Gian Maria, De Berardinis, Ettore, Cioffi, Antonio, Perdonà, Sisto, Borghesi, Marco, Schiavina, Riccardo, Cozzi, Gabriele, Almeida, Gilberto L., Bove, Pierluigi, Lima, Estevao, Grimaldi, Giovanni, Matei, Deliu Victor, Crisan, Nicolae, Muto, Matteo, Verze, Paolo, Battaglia, Michele, Guazzoni, Giorgio, Autorino, Riccardo, Morgia, Giuseppe, Damiano, Rocco, de Cobelli, Ottavio, Shariat, Shahrokh, Mirone, Vincenzo, and Lucarelli, Giuseppe

Published
2019
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50. Liquid biopsies and cancer omics

Author

Amelio, Ivano, Bertolo, Riccardo, Bove, Pierluigi, Buonomo, Oreste Claudio, Candi, Eleonora, Chiocchi, Marcello, Cipriani, Chiara, Di Daniele, Nicola, Ganini, Carlo, Juhl, Hartmut, Mauriello, Alessandro, Marani, Carla, Marshall, John, Montanaro, Manuela, Palmieri, Giampiero, Piacentini, Mauro, Sica, Giuseppe, Tesauro, Manfredi, Rovella, Valentina, Tisone, Giuseppe, Shi, Yufang, Wang, Ying, and Melino, Gerry

Published
2020
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