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7. Damped Ly-alpha Absorbers in Star-forming Galaxies at z < 0.15 Detected with the Hubble Space Telescope and Implications for Galaxy Evolution

Author

Kulkarni, Varsha P., Bowen, David V., Straka, Lorrie A., York, Donald G., Gupta, Neeraj, Noterdaeme, Pasquier, and Srianand, Raghunathan

Subjects
Astrophysics - Astrophysics of Galaxies, Physics - Space Physics
Abstract

We report {\it HST} COS spectroscopy of 10 quasars with foreground star-forming galaxies at 0.02$<$$z$$<$ 0.14 within impact parameters of $\sim$1-7 kpc. We detect damped/sub-damped Ly$\alpha$ absorption in 100$\%$ of cases where no higher-redshift Lyman-limit systems extinguish the flux at the expected wavelength of Ly$\alpha$ absorption, obtaining the largest targeted sample of DLA/sub-DLAs in low-redshift galaxies. We present absorption measurements of neutral hydrogen and metals. Additionally, we present GBT 21-cm emission measurements for 5 of the galaxies (including 2 detections). Combining our sample with the literature, we construct a sample of 115 galaxies associated with DLA/sub-DLAs spanning 0$<$$z$$<$4.4, and examine trends between gas and stellar properties, and with redshift. The H~I column density is anti-correlated with impact parameter and stellar mass. More massive galaxies appear to have gas-rich regions out to larger distances. The specific SFR (sSFR) of absorbing galaxies increases with redshift and decreases with $M^{\ast}$, consistent with evolution of the star-formation main sequence (SFMS). However, $\sim$20$\%$ of absorbing galaxies lie below the SFMS, indicating that some DLA/sub-DLAs trace galaxies with longer-than-typical gas-depletion time-scales. Most DLA/sub-DLA galaxies with 21-cm emission have higher H I masses than typical galaxies with comparable $M^{\ast}$. High $M_{\rm H I}/M^{\ast}$ ratios and high sSFRs in DLA/sub-DLA galaxies with $M^{\ast}$$<$$10^{9}$$M_{\odot}$ suggest these galaxies may be gas-rich because of recent gas accretion rather than inefficient star formation. Our study demonstrates the power of absorption and emission studies of DLA/sub-DLA galaxies for extending galaxy-evolution studies to previously under-explored regimes of low $M^{\ast}$ and low SFR., Comment: 51 pages, 12 figures. Submitted to the Astrophysical Journal

Published
2021
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12. Absorption line abundances in the SMC-like galaxy UGC 5282: evidence for ISM dilution from inflows on kiloparsec scales

Author

Bowen, David V., Tripp, Todd M., Jenkins, Edward B., Pettini, Max, Chelouche, Doron, Cen, Renyue, and York, Donald G.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present an HST Cosmic Origins Spectrograph (COS) spectrum of the QSO SDSS J095109.12+330745.8 ($z_{em} = 0.645$) whose sightline passes through the SMC-like dwarf galaxy UGC 5282 ($M_B = -16.0$, $cz = 1577$ km s$^{-1}$ ), 1.2 kpc in projection from the central HII region of the galaxy. Damped Ly$\alpha$ (DLA) absorption is detected at the redshift of UGC 5282 with $\log$[$N$(HI) cm$^{-2}\:$] = 20.89$^{+0.12}_{-0.21}\:\:$. Analysis of the accompanying SII, PII and OI metal lines yields a neutral gas metallicity, $Z_{HI}$, of [S/H] $\simeq$ [P/H] $= -0.80\pm0.24$. The metallicity of ionized gas from the central HII region, $Z_{HII}\:$, measured from its emission lines is [O/H]$= -0.37\pm0.10$, a difference of $+0.43\pm 0.26$ from $Z_{HI}\:$. This difference $\delta$ is consistent with that seen towards HII regions in other star-forming galaxies and supports the idea that ionized gas near star forming regions shows systematically higher metallicities than exist in the rest of a galaxy's neutral interstellar medium (ISM). The positive values of $\delta$ found in UGC 5282 (and the other star forming galaxies) is likely due to infalling low metallicity gas from the intergalactic medium that mixes with the galaxy's ISM on kpc scales. This model is also consistent with broad Ly$\alpha$ emission detected at the bottom of the DLA absorption, offset by $\sim 125$ km s$^{-1}$ from the absorption velocity. Models of galaxy evolution that attempt to replicate population characteristics, such as the mass-metallicity relation, may need to start with a galaxy metallicity represented by $Z_{HI}$ rather than that measured traditionally from $Z_{HII}\:$., Comment: Accepted for publication in ApJ. This version: typos corrected, references updated

Published
2020
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13. The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management

Author

Anstey, James, Plummer, Mark, Bellapart, Judith, Chow, Andrew, Delaney, Anthony, Bihari, Shailesh, Bowen, David, Reade, Michael, Jeffree, Lindy, Fitzgerald, Melinda, O'Brien, Terry, Nichol, Alistair, Bellomo, Rinaldo, Cooper, Jamie, Trapani, Tony, Battistuzzo, Camila, Tsigaras, Zac A., Weeden, Mark, McNamara, Robert, Jeffcote, Toby, and Udy, Andrew A.

Published
2023
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14. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study

Author

Anstey, Matthew, Colica, Sandra, Brewster, David, Simpson, Shannon, Regli, Adrian, O'Grady, Ross, Litton, Edward, Ferrier, Janet, Bartholdy, Roland, Tabah, Alexis, Bowen, David, Rowley, Rebecca, Gatward, Jonathan, Alonso, Julio, Varkey, Sneha, Palaniswamy, Vijayanand, Chimunda, Timothy, Reza, Syed T., Hossain, Mozaffer, Islam, Motiul, Hamid, Tarikul, Parotto, Matteo, Ajami, Samareh, Steel, Andrew, Del Sorbo, Lorenzo, Goffi, Alberto, Randall, Ian, Adhikari, Neill K.J., Mehesry, Tasneem H., Vera, Maria M., Bugedo, Guillermo, Labarca, Gonzalo, Silva, Monica, Ma, Wuhua, Li, Yongxing, Wu, Jiayan, Wu, Lun, Radivojević, Renata Curić, Matas, Marijana, Ivančan, Višnja, Pavlek, Mario, Mihaljević, Slobodan, Jumić, Aleksandra, Moguš, Mate, Tucić, Iva, Michalek, Pavel, Flaksa, Marek, Aguirre-Bermeo, Hernan, Tirape-Castro, Hugo, García Aguilera, Maria F., Montenegro, Diana Alvarez, Tutillo, Diego Morocho, Tutillo León, Jose A., Winiszewski, Hadrien, Piton, Gael, Aissaoui, Nadia, Augy, Jean-Loup, Champigneulle, Benoit, Zlotnik, Diane, Muller, Grégoire, Jacquier, Sophie, Hraiech, Sami, Guervilly, Christophe, Plantefeve, Gaetan, Contou, Damien, Ricard, Jean Damien, Besset, Sebastien, Colin, Gwenhael, Pouplet, Caroline, Mirouse, Adrien, Azoulay, Elie, Boissier, Florence, Frat, Jean-Pierre, Mercier, Emmanuelle, Salmon-Gandonnière, Charlotte, Lascarrou, Jean-Baptiste, Martin, Maelle, Ferre, Alexis, Legriel, Stephane, Bruel, Cedric, Philippard, Francois, Zarka, Jonathan, Chemouni, Frank, Hamzaoui, Olfa, Sztrymf, Benjamin, Brunin, Yannick, Pili-Floury, Sébastien, Constantin, Jean-Michel, Godet, Thomas, Maraffi, Tommaso, Dessap, Armand Mekontso, Jozwiak, Mathieu, Marin, Nathalie, Guitton, Christophe, Chudeau, Nicolas, Gros, Alexandre, Boyer, Alexandre, Papandreou, Eleni, Petsiou, Athanasia, Papanikolaou, Metaxia, Kyparissi, Aikaterini, Tileli, Maria, Makris, Alexandros, Tsiftsis, Dimitrios, El-Fellah, Nadia, Karametos, Ilias, Nakou, Evi, Chalkias, Athanasios, Arnaoutoglou, Eleni, Katsoulis, Panagiotis, Pouriki, Sofia, Vagdatli, Kyriaki, Dimitropoulou, Aikaterini, Kothekar, Amol, Baliga, Nishanth, Korula, Sara V., Philip, Sam, Singh, Lalit, Agrawal, Nipun, Jeswani, Deepak, Jeswani, Deepti, Jha, Simant, Singh, Nitesh, Bhattacharyya, Mahuya, Das, Amit, Kuragayala, Swarna D., Kesavarapu, Subba R., Shah, Bhagyesh, Kaushik, Shuchi, Sunil, Nilu, Gnanadurai, Kingsly, Singh, Atul K., Singh, Dinesh K., Khunteta, Sudhir, Gupta, Kulbhusahn, Sanyal, Rhik, Midya, Abhirup, Tyagi, Vijay N., Bendre, Prashant, Prashant, Kumar, Chaurasia, Satish, Mishra, Prasanna, Dash, Sampat, Sundrani, Omprakash, Lalwani, Jaya, Jain, Nikhilesh, Agrawal, Kehari, Ray, Banambar, Meher, Ranjan, Saravanabavan, Lakshmikanthcharan, Munusamy, Satheesh, Gupta, Manish, Ahmad, Meraj, Gopalakrishna, Kadarapura N., Suparna, Bharadwaj, Surath, Manimala R., Munta, Kartik, Jagiasi, Bharat, Srivastava, Anand, Sahu, Samir, Mrinal, Sircar, Kumar, Singh Sujeet, Shah, Mehul, Patel, Mayur, Bamane, Shrirang, Narkhede, Amit, Chawla, Rajesh, Chawla, Aakanksha, Maheshwarappa, Harish Mallapura, Manjunath, Ramya Ballekatte, Rahmani, Lua, Laffey, John G., Rona, Roberto, Benini, Annalisa, Russotto, Vincenzo, Rundo, Annalisa, Luzi, Annalisa, Esposito, Clelia, Nespoli, Moana R., Pradella, Andrea, Lungu, Ramona, Baccari, Laura, Chiumiento, Fernando, Mariano, Karim, Cotoia, Antonella, De Rosa, Silvia, Boni, Elisa, Palmese, Salvatore, Gammaldi, Renato, Spadaro, Savino, Santoro, Lida, Cracchiolo, Andrea N., Palma, Daniela M., Pinciroli, Riccardo, Giovannini, Ilaria, Calamai, Italo, Spina, Rosario, Cappellini, Iacopo, Tutino, Lorenzo, Bellissima, Agrippino, Maugeri, Jessica G., Riva, Ivano, Fabretti, Fabrizio, Brazzi, Luca, Sales, Gabriele, Montrucchio, Giorgia, Orsello, Alberto, Costamagna, Andrea, Canavosio, Federico G., Pelagalli, Lorella, Marcelli, Maria E., Cortegiani, Andrea, Tramarin, Jacopo, Musso, Stefania, Tarantino, Stefano, Di Giacinto, Ida, Licciardi, Anna L., Montini, Luca, De Pascale, Gennaro, Giacomucci, Angelo, Russo, Pierpaolo, Longhini, Federico, Garofalo, Eugenio, Ferluga, Massimo, Moro, Valeria, Cascella, Marco, Di Caprio, Barbara, Di Fenza, Raffaele, Nespoli, Francesca, Bassini, Ospedale E., Muttini, Stefano, Pezzi, Angelo, Elhadi, Muhammed, Ghula, Mohamed, Ahmed, Hazem Abdelkarem, Khaled, Ala, Elhadi, Ahmed, Alhadi, Abdulmueti, Mazlan, Mohd Z., Wan Hassan, Wan Mohd N., Hasan, Shahnaz, Jamaluddin, Muhamad F.H., Samat, Noryani Mohd, Ismail, Muhamad A., Alias, Anita, Hwa, Ngu Pei, Irtiza, Ismail Nahla, Khalidah, Hapiz, Kiok, Lee Chew, Nordin, Norbaniza Mohd, Wan Ismail, Wan N., Ali, Mohd N., Sánchez-Hurtado, Luis, Toledo-Salinas, Otoniel, Landaverde, Antonio, Sosa, Miguel A., Gonzalez, Mayra Martinez, Lopez Nava, Claudia L., San Juan Roman, Nandyelly, Gonzalez, Maria, Espinoza, Missael, González, Daira, Flores, Fernando, Pantoja Leal, Jesus N., Loza Gallardo, Luis R., Young, Paul, Mistry, Ravi, Browne, Alexander, Crone, Petra, Chandwani, Juhi, Hossein, Sazzad, Koul, Salman S., Aman, Rubina, Ali, Syed M., Akhtar, Shazia N., Jankowski, Milosz, Bielanski, Piotr, Mudyna, Wojciech, Franczyk, Pawel, Galkin, Piotr, Skowronski, Lukasz, Gaszynski, Tomasz, Piegat, Mariusz, Catorze, Nuno, Pinto, Marcia, Leonor, Tiago, Fernandes, Marco, Campos, Patricia, Aragão, Irene, Costa, Paulo F., Franco, Daniela G., Basto, Marta, Nogueira, Carla, Cunha, Rui P., Costa, Vasco, Lomivorotov, Vladimir, Nikitenko, Artem, Belsky, Vladislav, Furman, Mikhail, Magomedov, Marat, Baturova, Vera, Karelov, Alexey, Marova, Nadezhda, Almekhlafi, Ghaleb, Alghamdi, Adnan, Maseda, Emilio, Suarez de la Rica, Alejandro, Gonzalez, Jesus Flores, Ruiz, Miryam Pérez, Roca, Oriol, Santafe, Manel, Fernandez, Gemma Goma, Escudero-Acha, Patricia, González-Castro, Alejandro, Agvald-Öhman, Christina, Broman, Lina, Spangfors, Martin, Hannesdottir, Katrin, Persson, Elin, Rosell, Jon, Sperber, Jesper, Ohlsson, Annika, Von Seth, Magnus, Pedrotti, Niccolò, Wahlstrom, Carl, Meirik, Maria, Bandert, Anna, Krog, Ditte, Kuo, Lu-Cheng, Shin, Ming-Hann, Chien, Jung-Yien, Ku, Shih-Chi, Ruan, Sheng-Yuan, Huang, Chun-Kai, Yeh, Yu-Chang, Chao, Anne, Wang, Kuo-Chuan, Chiu, Ching-Tang, Lee, Chien-Chang, Chou, Nai-Kuan, Szakmany, Tamas, Jones, Benjamin, Jones, Laura, Della Torre, Valentina, Sinah, Ayush, Quayle, Alice, Cheetham, Olivia, Syed, Yadullah, Mensah, Kwabena, Edmunds, Christopher, Kaye, Callum T., Bauer, Philippe R., Odeyemi, Yewande E., Nates, Joseph, Laserna, Andres, Mosier, Jarrod, Hypes, Cameron, Gottesman, Eric, Mastroianni, Fiore, Fein, Daniel G., Zhao, Dawn, Fonseca Fuentes, Xavier E., Gallo de Moraes, Alice, Sandefur, Benjamin J., Khan, Akram, Matos, Dubier, Kaufman, David A., Lehr, Andrew, Bigatello, Luca, Bonney, Iwona, Lascarrou, Jean Baptiste, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Grasselli, Giacomo, Valsecchi, Maria G., Fumagalli, Roberto, Foti, Giuseppe, Caironi, Pietro, Bellani, Giacomo, and Myatra, Sheila N.

Published
2023
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16. Determinants of low health-related quality of life in patients with myelodysplastic syndromes: EUMDS Registry study

Author

Stojkov, Igor, Conrads-Frank, Annette, Rochau, Ursula, Arvandi, Marjan, Koinig, Karin A., Schomaker, Michael, Mittelman, Moshe, Fenaux, Pierre, Bowen, David, Sanz, Guillermo F., Malcovati, Luca, Langemeijer, Saskia, Germing, Ulrich, Madry, Krzysztof, Guerci-Bresler, Agnès, Culligan, Dominic J., Kotsianidis, Ioannis, Sanhes, Laurence, Mills, Juliet, Puntscher, Sibylle, Schmid, Daniela, van Marrewijk, Corine, Smith, Alexandra, Efficace, Fabio, de Witte, Theo, Stauder, Reinhard, and Siebert, Uwe

Published
2023
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17. A Sub-Damped Ly$\alpha$ Absorber with Unusual Abundances: Evidence of Gas Recycling in a Low-Redshift Galaxy Group

Author

Frye, Brenda, Bowen, David V., Tripp, Todd M., Jenkins, Ed, Pettini, Max, and Ellison, Sara L.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Using Hubble Space Telescope/Space Telescope Imaging Spectrograph G140M spectroscopy, we investigate an absorption-line system at $z$=0.07489 in the spectrum of the quasi-stellar object PG 1543+489 ($z_{QSO}$=0.401). The sightline passes within $\rho = 66$ kpc of an edge-on $2L^*$ disk galaxy at a similar redshift, but the galaxy belongs to a group with four other galaxies within $\rho =160$ kpc. We detect H I [log $N$(H I/$cm^{-2}$) = 19.12$\pm$0.04] as well as N I, Mg II, Si II, and Si III, from which we measure a gas-phase abundance of [N/H] = $-1.0\pm 0.1$. Photoionization models indicate that the nitrogen-to-silicon relative abundance is solar, yet magnesium is underabundant by a factor of $\approx$ 2. We also report spatially resolved emission-line spectroscopy of the nearby galaxy, and we extract its rotation curve. The galaxy's metallicity is $\approx 8 \times$ higher than [N/H] in the absorber, and interestingly, the absorber velocities suggest that the gas at $\rho =$ 66 kpc is corotating with the galaxy's stellar disk, possibly with an inflow component. These characteristics could indicate that this sub-damped Ly$\alpha$ absorber system arises in a "cold-accretion" flow. However, the absorber abundance patterns are peculiar. We hypothesize that the gas was ejected from its galaxy of origin (or perhaps is a result of tidal debris from interactions between the group galaxies) with a solar nitrogen abundance, but that subsequently mixed with (and was diluted by) gas in the circumgalactic medium (CGM) or group. If the gas is bound to the nearby galaxy, this system may be an example of the gas "recycling" predicted by theoretical galaxy simulations. Our hypothesis is testable with future observations., Comment: 16 pages (in print): The Astrophysical Journal, vol 872, 129

Published
2019
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19. International Analgesia and Sedation Weaning and Withdrawal Practices in Critically Ill Adults: The Adult Iatrogenic Withdrawal Study in the ICU*

Author

Bolesta, Scott, Burry, Lisa, Perreault, Marc M., Gélinas, Céline, Smith, Kathryn E., Eadie, Rebekah, Carini, Federico C., Saltarelli, Katrianna, Mitchell, Jennifer, Harpel, Jamie, Stewart, Ryan, Riker, Richard R., Fraser, Gilles L., Erstad, Brian L., Alcántara, Sara, Aldardeer, Namareq, Alhammad, Abdullah, Almohaish, Sulaiman, Ammar, Mahmoud, Arroyo-Novoa, Carmen Mabel, Awassi, Don-Kelena, Badano, Mariana, Badman, Belinda, Barnes, Sanchia, Bertozzi, Matias, Botros, Shady, Brophy, Gretchen, Brown, Caitlin, Brown, Glen, Buckley, Mitchell, Burgess, Sarah, Campbell, Joshua, Carothers, Chancey, Celario, Patricio, Chambers, Lauren, Chanques, Gérald, Contreras, Sofia, d’Hebron, Vall, Cortes, Jennifer, Cozzi, Gabrielle, Cucci, Michaelia, Cunto, Eleonora, Dao, Denis, Defayette, Aubrey, Dey, Alexandra, Diaz, Anatilde, Dixit, Deepali, Dube, Jean-Noel, Duceppe, Marc-Alexandre, Dzierba, Amy, Farrell, Odran, Ferranti, Pietro, Flannery, Alexander, Fontaine, Gabriel, Forehand, Christy, Nelson, Nydia Funes, Gillet, Manon, Gonzalez, Gustavo Nicolas, Graham-Clarke, Emma, Green, Sarah, Groth, Christine, Hamid, Hytham, Hamilton, Leslie, Hanley, Joanne, Jackson, Jessica, Johnston, Jackie, Kanji, Salmaan, Katzman, Sam, Kenes, Michael, Kinney, Justin, Kohler, Claire, Kovacic, Nicole, Kuroski, Julia, Landolf, Kaitlin, Laotheerachao, Rosalynn, Largana, Samuel, Lebrun, Genevieve, Leonardo, Kate, Levins, Elizabeth, Lewis-Wolfson, Temeka, Mailman, Jonathan, Man, Anna, Mandich, Veronica, McCullagh, Iain, McDonald, Jill, Gil, Antonella Milano, Ng, Wing Sum (Winny), Nguyen, Hang, O’Hare, Madeline, saleh, Jesus eduardo Ochoa, Oswald, Christopher, Patanwala, Asad, Payen, Jean-Francois, Phan, Brian, Radosevich, John, Reiter, Tamara, Remmington, Christopher, Reyes, Viviana, Roberts, Russel, Sagardia, Judith, Sall, Jas, Sanchez, Diego, Shoulders, Bethany, Sneyers, Barbara, Thiboutot, Zoe, Thompson, Melissa, Timmins, Alan, Tolosa, Carina Fernanda, Tolosa, Carina, Junin, Sanatorio, Torres, Valentin Gabriel, Tran, Sandy, Trinh, Thu Ha, Tynan, Sinead, Vu, Lan, Wilson, Franki, Cook, Aaron, Ciolek, Alana, Haines, Aleina, Rodriguez, Alejandra, Cheung, Alexandra, Leong, Amanda, Nisnik, Ana Laura, Mancilla, Ana Maria, Rinehimer, Brandon, Sloan, Brett, Bissell, Brittany, Kulilg, Caitlin, Coombe, Cassandra, Dominguez, Cecilia, Wampole, Chelsea, Rodriguez de la Quintana, Cristhian, Mulodjanov, Darina, Tsoller, Darina, Bowen, David, Gagnon, David, Purkayastha, Debanjali, Ali, Dina, Saidahmed, Elfayadh, Lewandowski, Emily, Schranz, Emily, MacNeil, Erin, Hanks, Fraser, Kassab, Hager, Brokmeier, Hannah, Kaur, Jaspreet, Huntress, Jeff, Clark, Jenna, Falvey, Jennifer, De Giacomo, Jessica, Smith, Jonathan, Ibarzabal, Juan, Niland, Judith, Muir, Justin, Gosek, Kasia, Maynard, Kaylee, Kooda, Kirstin, Pandya, Komal, Kaupp, Kristin, Ebitt, Laura, Bordon, Lucas, Chiscano, Lusi, Sosa, Manuel, Cosep, Marc, Lobo, Marcelo, Monte, Marco Flores, Sandler, Melissa, Bastin, Melissa Thompson, Armahizer, Michael, Wang, Michelle, Eshaghian, Miriam, Rizwan, Mohammad, Patel, Mona, Pistillo, Nestor, Harris, Nicole, Torella, Pau, Phongsamran, Paula, Woo, Priscilla, Garcia, Rhiannon, Sabelli, Rosana Gregori, Grant, Ryan, Delibert, Samantha, Parli, Sara, Wilson, Sharon, Yeung, Siu Yan Amy, Putruele, Sofia, Rappaport, Stephen, Welch, Susan, Moitra, Vivek, and Chediack, Viviana

Published
2023
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21. The Red Dead Redemption Survey of Circumgalactic Gas About Massive Galaxies. I. Mass and Metallicity of the Cool Phase

Author

Berg, Michelle A., Howk, J. Christopher, Lehner, Nicolas, Wotta, Christopher B., O'Meara, John M., Bowen, David V., Burchett, Joseph N., Peeples, Molly S., and Tejos, Nicolas

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present a search for HI in the circumgalactic medium (CGM) of 21 massive ($\langle \log M_\star \rangle \sim 11.4$), luminous red galaxies (LRGs) at $z\sim0.5$. Using UV spectroscopy of QSO sightlines projected within 500 kpc ($\sim R_{vir}$) of these galaxies, we detect HI absorption in 11/21 sightlines, including two partial Lyman limit systems and two Lyman limit systems. The covering factor of $\log N(HI) \ge 16.0$ gas within the virial radius of these LRGs is $f_c(\rho \le R_{vir}) = 0.27^{+0.11}_{-0.10}$, while for optically-thick gas ($\log N(HI) \ge 17.2$) it is $f_c(\rho \le R_{vir}) = 0.15^{+0.10}_{-0.07}$. Combining this sample of massive galaxies with previous galaxy-selected CGM studies, we find no strong dependence of the HI covering factor on galaxy mass, although star-forming galaxies show marginally higher covering factors. There is no evidence for a critical mass above which dense, cold ($T \sim 10^4$ K) gas is suppressed in the CGM of galaxies (spanning stellar masses $9.5 \lesssim \log M_\star \lesssim 11.8$). The metallicity distribution in LRGs is indistinguishable from those found about lower-mass star-forming galaxies, and we find low-metallicity gas with $[{\rm X/H}] \approx -1.8$ (1.5% solar) and below about massive galaxies. About half the cases show super-solar [FeII/MgII] abundances as seen previously in cool gas near massive galaxies. While the high-metallicity cold gas seen in LRGs could plausibly result from condensation from a corona, the low-metallicity gas is inconsistent with this interpretation., Comment: Key figures: 8 and 10, Accepted for publication in ApJ. Updated after referee comments, New subsection 5.3 and Appendix D

Published
2018
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22. The COS Absorption Survey of Baryon Harbors (CASBaH): Warm-hot Circumgalactic Gas Reservoirs Traced by Ne VIII Absorption

Author

Burchett, Joseph N., Tripp, Todd M., Prochaska, J. Xavier, Werk, Jessica K., Tumlinson, Jason, Howk, J. Christopher, Willmer, Christopher N. A., Lehner, Nicolas, Meiring, Joseph D., Bowen, David V., Bordoloi, Rongmon, Peeples, Molly S., Jenkins, Edward B., O'Meara, John M., Tejos, Nicolas, and Katz, Neal

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We survey the highly ionized circumgalactic media (CGM) of 29 blindly selected galaxies at 0.49 < z_(gal) < 1.44 based on high-S/N ultraviolet spectra of z > 1 QSOs and the galaxy database from the COS Absorption Survey of Baryon Harbors (CASBaH). We detect the Ne VIII doublet in nine of the galaxies, and for gas with N(Ne VIII) > 10^13.3 cm^-2 (> 10^13.5 cm^-2), we derive a Ne VIII covering fraction f_c = 75 +15/-25% (44 +22/-20%) within impact parameter (rho) < 200 kpc of M_* = 10^(9.5-11.5) Msol galaxies and f_c = 70 +16/-22% (f_c = 42 +20/-17%) within rho < 1.5 virial radii. We estimate the mass in Ne VIII-traced gas to be M_gas(Ne VIII) > 10^9.5 Msol (Z/Zsol)^-1, or 6-20% of the expected baryonic mass if the Ne VIII absorbers have solar metallicity. Ionizing Ne VII to Ne VIII requires 207 eV, and photons with this energy are scarce in the CGM. However, for the median halo mass and redshift of our sample, the virial temperature is close to the peak temperature for the Ne VIII ion, and the Ne VIII-bearing gas is plausibly collisionally ionized near this temperature. Moreover, we find that photoionized Ne VIII requires cool and low-density clouds that would be highly underpressured (by approximately two orders of magnitude) relative to the putative, ambient virialized medium, complicating scenarios where such clouds could survive. Thus, more complex (e.g., non-equilibrium) models may be required; this first statistical sample of Ne VIII absorber/galaxy systems will provide stringent constraints for future CGM studies., Comment: Published in ApJL, Volume 877, Issue 2, Article L20

Published
2018
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23. Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus.

Author

Mekonnen, Zelalem A, Grubor-Bauk, Branka, English, Kieran, Leung, Preston, Masavuli, Makutiro G, Shrestha, Ashish C, Bertolino, Patrick, Bowen, David G, Lloyd, Andrew R, Gowans, Eric J, and Wijesundara, Danushka K

Subjects
DNA vaccine, adeno-associated virus vaccine, cytotoxic T cells, helper T cells, hepatitis C virus vaccine, liver immunity, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

Hepatitis C virus (HCV) is a significant contributor to the global disease burden, and development of an effective vaccine is required to eliminate HCV infections worldwide. CD4+ and CD8+ T cell immunity correlates with viral clearance in primary HCV infection, and intrahepatic CD8+ tissue-resident memory T (TRM) cells provide lifelong and rapid protection against hepatotropic pathogens. Consequently, we aimed to develop a vaccine to elicit HCV-specific CD4+ and CD8+ T cells, including CD8+ TRM cells, in the liver, given that HCV primarily infects hepatocytes. To achieve this, we vaccinated wild-type BALB/c mice with a highly immunogenic cytolytic DNA vaccine encoding a model HCV (genotype 3a) nonstructural protein (NS5B) and a mutant perforin (pVAX-NS5B-PRF), as well as a recombinant adeno-associated virus (AAV) encoding NS5B (rAAV-NS5B). A novel fluorescent target array (FTA) was used to map immunodominant CD4+ T helper (TH) cell and cytotoxic CD8+ T cell epitopes of NS5B in vivo, which were subsequently used to design a KdNS5B451-459 tetramer and analyze NS5B-specific T cell responses in vaccinated mice in vivo The data showed that intradermal prime/boost vaccination with pVAX-NS5B-PRF was effective in eliciting TH and cytotoxic CD8+ T cell responses and intrahepatic CD8+ TRM cells, but a single intravenous dose of hepatotropic rAAV-NS5B was significantly more effective. As a T-cell-based vaccine against HCV should ideally result in localized T cell responses in the liver, this study describes primary observations in the context of HCV vaccination that can be used to achieve this goal.IMPORTANCE There are currently at least 71 million individuals with chronic HCV worldwide and almost two million new infections annually. Although the advent of direct-acting antivirals (DAAs) offers highly effective therapy, considerable remaining challenges argue against reliance on DAAs for HCV elimination, including high drug cost, poorly developed health infrastructure, low screening rates, and significant reinfection rates. Accordingly, development of an effective vaccine is crucial to HCV elimination. An HCV vaccine that elicits T cell immunity in the liver will be highly protective for the following reasons: (i) T cell responses against nonstructural proteins of the virus are associated with clearance of primary infection, and (ii) long-lived liver-resident T cells alone can protect against malaria infection of hepatocytes. Thus, in this study we exploit promising vaccination platforms to highlight strategies that can be used to evoke highly functional and long-lived T cell responses in the liver for protection against HCV.

Published
2019

24. TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

Author

Haase, Detlef, Stevenson, Kristen E, Neuberg, Donna, Maciejewski, Jaroslaw P, Nazha, Aziz, Sekeres, Mikkael A, Ebert, Benjamin L, Garcia-Manero, Guillermo, Haferlach, Claudia, Haferlach, Torsten, Kern, Wolfgang, Ogawa, Seishi, Nagata, Yasunobu, Yoshida, Kenichi, Graubert, Timothy A, Walter, Matthew J, List, Alan F, Komrokji, Rami S, Padron, Eric, Sallman, David, Papaemmanuil, Elli, Campbell, Peter J, Savona, Michael R, Seegmiller, Adam, Adès, Lionel, Fenaux, Pierre, Shih, Lee-Yung, Bowen, David, Groves, Michael J, Tauro, Sudhir, Fontenay, Michaela, Kosmider, Olivier, Bar-Natan, Michal, Steensma, David, Stone, Richard, Heuser, Michael, Thol, Felicitas, Cazzola, Mario, Malcovati, Luca, Karsan, Aly, Ganster, Christina, Hellström-Lindberg, Eva, Boultwood, Jacqueline, Pellagatti, Andrea, Santini, Valeria, Quek, Lynn, Vyas, Paresh, Tüchler, Heinz, Greenberg, Peter L, Bejar, Rafael, and International Working Group for MDS Molecular Prognostic Committee

Subjects
International Working Group for MDS Molecular Prognostic Committee, Humans, Myelodysplastic Syndromes, Chromosome Aberrations, Prognosis, Combined Modality Therapy, Survival Rate, Follow-Up Studies, Karyotyping, Mutation, Aged, Aged, 80 and over, Middle Aged, Female, Male, Tumor Suppressor Protein p53, Biomarkers, Tumor, Hematology, Rare Diseases, Genetics, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnormalities and somatic mutations. To refine risk stratification of CK-MDS patients, we examined data from 359 CK-MDS patients shared by the International Working Group for MDS. Mutations were underrepresented with the exception of TP53 mutations, identified in 55% of patients. TP53 mutated patients had even fewer co-mutated genes but were enriched for the del(5q) chromosomal abnormality (p 10%), abnormal 3q, abnormal 9, and monosomy 7 as having the greatest survival risk. The poor risk associated with CK-MDS is driven by its association with prognostically adverse TP53 mutations and can be refined by considering clinical and karyotype features.

Published
2019

25. Potential CO2 and brine leakage through wellbore pathways for geologic CO2 sequestration using the National Risk Assessment Partnership tools: Application to the Big Sky Regional Partnership

Author

Onishi, Tsubasa, Nguyen, Minh C, Carey, J William, Will, Bob, Zaluski, Wade, Bowen, David W, Devault, Bryan C, Duguid, Andrew, Zhou, Quanlin, Fairweather, Stacey H, Spangler, Lee H, and Stauffer, Philip H

Subjects
Earth Sciences, Geology, Life on Land, Geologic CO2 sequestration, Uncertainty assessment, Risk assessment, Reservoir simulation, Design of experiment, Environmental Sciences, Engineering, Energy, Earth sciences, Environmental sciences
Abstract

Geologic CO2 sequestration (GCS) has received high-level attention from the global scientific community as a response to climate change due to higher concentrations of CO2 in the atmosphere. However, GCS in saline aquifers poses certain risks including CO2/brine leakage through wells or non-sealing faults into groundwater or to the earth's surface. Understanding crucial reservoir parameters and other geologic features affecting the likelihood of these leakage occurrences will aid the decision-making process regarding GCS operations. In this study, we develop a science-based methodology for quantifying risk profiles at geologic CO2 sequestration sites as part of US DOE's National Risk Assessment Partnership (NRAP). We apply NRAP tools to a field scale project in a fractured saline aquifer located at Kevin Dome, Montana, which is part of DOE's Big Sky Carbon Sequestration Partnership project. Risks associated with GCS injection and monitoring are difficult to quantify due to a dearth of data and uncertainties. One solution is running a large number of numerical simulations of the primary CO2 injection reservoir, shallow reservoirs/aquifers, faults, and wells to address leakage risks and uncertainties. However, a full-physics simulation is not computationally feasible because the model is too large and requires fine spatial and temporal discretization to accurately reproduce complex multiphase flow processes. We employ the NRAP Integrated Assessment Model (NRAP-IAM), a hybrid system model developed by the US-DOE for use in performance and quantitative risk assessment of CO2 sequestration. The IAM model requires reduced order models (ROMs) developed from numerical reservoir simulations of a primary CO2 injection reservoir. The ROMs are linked with discrete components of the NRAP-IAM including shallow reservoirs/aquifers and the atmosphere through potential leakage pathways. A powerful stochastic framework allows NRAP-IAM to be used to explore complex interactions among a large number of uncertain variables and to help evaluate the likely performance of potential sequestration sites. Using the NRAP-IAM, we find that the potential amount of CO2 leakage is most sensitive to values of permeability, end-point CO2 relative permeability, hysteresis of CO2 relative permeability, capillary pressure, and permeability of confining rocks. In addition to demonstrating the application of the NRAP risk assessment tools, this work shows that GCS in the Kevin Dome has a higher probability of encountering injectivity limitations during injection of CO2 into the Middle Duperow formation than previous studies have calculated. Finally, we estimate very low risk of CO2 leakage to the atmosphere unless the quality of the legacy well completions is extremely poor.

Published
2019

28. On local sensing of spin Hall effect in tungsten films by using STM-based measurements

Author

Xie, Ting, Dreyer, Michael, Bowen, David, Hinkel, Dan, Butera, R. E., Krafft, Charles, and Mayergoyz, Isaak

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The spin Hall effect in tungsten films has been experimentally studied by using STM-based measurements. These measurements have been performed by using tungsten and iron coated tungsten tips. In the case of tungsten tips, it has been observed that the current flow through the tungsten film results in an appreciable asymmetry in the tunneling current with respect to the change in the polarity of the tunneling voltage. It is reasoned that the cause of this asymmetry is the accumulation of spin polarized electrons on the tungsten film surface due to the spin Hall effect. This asymmetry is not affected by the change of the direction of the bias current through the film. However, in the case of iron coated tungsten tips, it has been observed that a change in the direction of the bias current does lead to an additional asymmetry in the tunneling current. It is thus experimentally demonstrated that this asymmetry is caused by the SHE and spin-dependent density of states of iron-coated tips., Comment: 20 pages, 11 figures

Published
2017
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29. A scanning tunneling microscopy based potentiometry technique and its application to the local sensing of the spin Hall effect

Author

Xie, Ting, Dreyer, Michael, Bowen, David, Hinkel, Dan, Butera, R. E., Krafft, Charles, and Mayergoyz, Isaak

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

A scanning tunneling microscopy based potentiometry technique for the measurements of the local surface electric potential is presented and illustrated by experiments performed on current-carrying thin tungsten films. The obtained results demonstrate a sub-millivolt resolution in the measured surface potential. The application of this potentiometry technique to the local sensing of the spin Hall effect is outlined and some experimental results are reported., Comment: 9 pages and 4 figures

Published
2017

30. Warm-hot Gas in X-ray Bright Galaxy Clusters and the H I-deficient Circumgalactic Medium in Dense Environments

Author

Burchett, Joseph N., Tripp, Todd M., Wang, Q. Daniel, Willmer, Christopher N. A., Bowen, David V., and Jenkins, Edward B.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We analyze the intracluster medium (ICM) and circumgalactic medium (CGM) in 7 X-ray detected galaxy clusters using spectra of background QSOs (HST-COS/STIS), optical spectroscopy of the cluster galaxies (MMT/Hectospec and SDSS), and X-ray imaging/spectroscopy (XMM-Newton and Chandra). First, we report a very low covering fraction of H I absorption in the CGM of these cluster galaxies, f_c = 25% +25%/-15%, to stringent detection limits (log N(H I) < 13 cm^-2). As field galaxies have an H I covering fraction of ~100% at similar radii, the dearth of CGM H I in our data indicates that the cluster environment has effectively stripped or overionized the gaseous halos of these cluster galaxies. Second, we assess the contribution of warm-hot (10^5 - 10^6 K) gas to the ICM as traced by O VI and broad Ly-alpha (BLA) absorption. Despite the high signal-to-noise of our data, we do not detect O VI in any cluster, and we only detect BLA features in the QSO spectrum probing one cluster. We estimate that the total column density of warm-hot gas along this line of sight totals to ~3% of that contained in the hot T > 10^7 K X-ray emitting phase. Residing at high relative velocities, these features may trace pre-shocked material outside the cluster. Comparing gaseous galaxy halos from the low-density 'field' to galaxy groups and high-density clusters, we find that the CGM is progressively depleted of H I with increasing environmental density, and the CGM is most severely transformed in galaxy clusters. This CGM transformation may play a key role in environmental galaxy quenching., Comment: 21 pages, 14 figures, 6 tables. Accepted for publication in MNRAS

Published
2017
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31. Inflammatory profile of lower risk myelodysplastic syndromes.

Author

Topping, Joanne, Taylor, Adele, Nadat, Fatima, Crouch, Simon, Ibbotson, Alice, Čermák, Jaroslav, Symeonidis, Argiris, Tatic, Aurelia, Langemeijer, Saskia, Hellström‐Lindberg, Eva, Culligan, Dominic, Garelius, Hege Gravdahl, Ashcroft, John, Nga, Emma, Parker, Jane, Kolade, Seye, McDermott, Michael F., De Witte, Theo, Bowen, David, and Smith, Alexandra

Subjects
RED blood cell transfusion, MYELODYSPLASTIC syndromes, NLRP3 protein, INFLAMMASOMES, INTERFERONS
Abstract

Summary: The precise link between inflammation and pathogenesis of myelodysplastic syndrome (MDS) is yet to be fully established. We developed a novel method to measure ASC/NLRP3 protein specks which are specific for the NLRP3 inflammasome only. We combined this with cytokine profiling to characterise various inflammatory markers in a large cohort of patients with lower risk MDS in comparison to healthy controls and patients with defined autoinflammatory disorders (AIDs). The ASC/NLRP3 specks were significantly elevated in MDS patients compared to healthy controls (p < 0.001) and these levels were comparable to those found in patients with AIDs. The distribution of protein specks positive only for ASC was different to ASC/NLRP3 ones suggesting that other ASC‐containing inflammasome complexes might be important in the pathogenesis of MDS. Patients with MDS‐SLD had the lowest levels of interleukin (IL)‐1β, tumour necrosis factor (TNF), IL‐23, IL‐33, interferon (IFN) γ and IFN‐α2, compared to other diagnostic categories. We also found that inflammatory cytokine TNF was positively associated with MDS progression to a more aggressive form of disease and IL‐6 and IL‐1β with time to first red blood cell transfusion. Our study shows that there is value in analysing inflammatory biomarkers in MDS, but their diagnostic and prognostic utility is yet to be fully validated. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Core set of patient-reported outcomes for myelodysplastic syndromes: an EUMDS Delphi study involving patients and hematologists

Author

Stojkov, Igor, Conrads-Frank, Annette, Rochau, Ursula, Koinig, Karin A., Arvandi, Marjan, Puntscher, Sibylle, van Marrewijk, Corine, Fenaux, Pierre, Symeonidis, Argiris, Chermat, Fatiha, Garelius, Hege, Bowen, David, Mittelman, Moshe, Mora, Elvira, de Witte, Theo, Efficace, Fabio, Siebert, Uwe, and Stauder, Reinhard

Published
2022
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35. A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

Author

Oster, Howard S., Crouch, Simon, Smith, Alexandra, Yu, Ge, Abu Shrkihe, Bander, Baruch, Shoham, Kolomansky, Albert, Ben-Ezra, Jonathan, Naor, Shachar, Fenaux, Pierre, Symeonidis, Argiris, Stauder, Reinhard, Cermak, Jaroslav, Sanz, Guillermo, Hellström-Lindberg, Eva, Malcovati, Luca, Langemeijer, Saskia, Germing, Ulrich, Holm, Mette Skov, Madry, Krzysztof, Guerci-Bresler, Agnes, Culligan, Dominic, Sanhes, Laurence, Mills, Juliet, Kotsianidis, Ioannis, van Marrewijk, Corine, Bowen, David, de Witte, Theo, and Mittelman, Moshe

Published
2021
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39. Hypomagnesaemia, an independent risk factor for the development of post‐transplant diabetes mellitus in liver and renal transplant recipients? A systematic review.

Author

Chen, Shujie, Bowen, David Geoffrey, Liu, Ken, and Vidot, Helen

Subjects
*DIABETES risk factors, *KIDNEY transplantation, *RISK assessment, *MEDICAL information storage & retrieval systems, *PATIENTS, *TRANSPLANTATION of organs, tissues, etc., *MAGNESIUM, *GLYCOSYLATED hemoglobin, *SURGICAL complications, *SYSTEMATIC reviews, *MEDLINE, *HYPOMAGNESEMIA, *LIVER transplantation, *DISEASE complications
Abstract

Background: Post‐transplantation diabetes mellitus (PTDM) is common after solid organ transplantation. In the past decade, there has been increasing interest in the association between hypomagnesaemia and the development of PTDM. This systematic review aimed to investigate the current knowledge regarding the association between hypomagnesaemia and PTDM in adult liver and renal transplant recipients. Methods: A literature search of five databases, Medline, Embase, ProQuest, Scopus and Google Scholar, as well as article reference lists, was performed. Eligible studies that focused on adult liver and renal transplant recipients without pretransplantation hyperglycaemia or diabetes were included. Other eligibility criteria included quantitative studies which reported magnesium concentrations, studies with at least 6 months of follow‐up, and studies published in English. The Newcastle–Ottawa Assessment Tool was used for the quality assessment. Results: In total, 12 studies were included in the final analysis. Eleven focused on renal transplantation and one on liver transplantation. All studies were medium to high quality with eight out of 12 achieving the highest rating of nine. Eight studies found a negative association between either pretransplant or early post‐transplant serum magnesium concentration and the risk of PTDM, three studies found no association between these two variables, and one study found a positive association between the magnesium concentration at 8 weeks after transplantation and glycosylated haemoglobin A1C. Conclusions: Further large‐scale prospective studies with at least 6 months of follow‐up are needed to confirm these findings, particularly in liver transplantation, to further clarify and explore the relationship between hypomagnesaemia and PTDM. Highlights: Magnesium is critical in glucose homeostasis.Low serum magnesium concentration is independently associated with the development of post‐transplant diabetes in renal transplant recipients and is implicated in the development of post‐transplant diabetes in liver transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Magellan LDSS3 emission confirmation of galaxies hosting metal-rich Lyman-alpha absorption systems

Author

Straka, Lorrie A., Johnson, Sean D., York, Donald G., Bowen, David V., Florian, Michael, Kulkarni, Varsha P., Lundgren, Britt, and Peroux, Celine

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Using the Low Dispersion Survey Spectrograph 3 at the Magellan II Clay Telescope, we target {candidate absorption host galaxies} detected in deep optical imaging {(reaching limiting apparent magnitudes of 23.0-26.5 in $g, r, i,$ and $z$ filters) in the fields of three QSOs, each of which shows the presence of high metallicity, high $N_{\rm HI}$ absorption systems in their spectra (Q0826-2230: $z_{abs}$=0.9110, Q1323-0021: $z_{abs}=0.7160$, Q1436-0051: $z_{abs}=0.7377, 0.9281$). We confirm three host galaxies {at redshifts 0.7387, 0.7401, and 0.9286} for two of the Lyman-$\alpha$ absorption systems (one with two galaxies interacting). For these systems, we are able to determine the star formation rates (SFRs); impact parameters (from previous imaging detections); the velocity shift between the absorption and emission redshifts; and, for one system, also the emission metallicity.} Based on previous photometry, we find these galaxies have L$>$L$^{\ast}$. The [O II] SFRs for these galaxies are in the range $11-25$ M$_{\odot}$ yr$^{-1}$ {(uncorrected for dust)}, while the impact parameters lie in the range $35-54$ kpc. {Despite the fact that we have confirmed galaxies at 50 kpc from the QSO, no gradient in metallicity is indicated between the absorption metallicity along the QSO line of sight and the emission line metallicity in the galaxies.} We confirm the anti-correlation between impact parameter and $N_{\rm HI}$ from the literature. We also report the emission redshift of five other galaxies: three at $z_{em}>z_{QSO}$, and two (L$<$L$^{\ast}$) at $z_{em}

Published
2015
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41. Galactic nebular lines in the fiber spectra of background QSOs: Reaching a hundred QSO-galaxy pairs with spectroscopic and photometric measurements

Author

Straka, Lorrie, Noterdaeme, Pasquier, Srianand, Raghunathan, Nutalaya, Songkiat, Kulkarni, Varsha P., Khare, Pushpa, Bowen, David, Bishof, Michael, and York, Donald G.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present photometric and spectroscopic measurements of 53 QSO-galaxy pairs from the Sloan Digital Sky Survey, where nebular emission lines from a 0

Published
2014
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42. Probing the Fermi Bubbles in Ultraviolet Absorption: A Spectroscopic Signature of the Milky Way's Biconical Nuclear Outflow

Author

Fox, Andrew J., Bordoloi, Rongmon, Savage, Blair D., Lockman, Felix J., Jenkins, Edward B., Wakker, Bart P., Bland-Hawthorn, Joss, Hernandez, Svea, Kim, Tae-Sun, Benjamin, Robert A., Bowen, David V., and Tumlinson, Jason

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Giant lobes of plasma extend 55 degrees above and below the Galactic Center, glowing in emission from gamma rays (the Fermi Bubbles) to microwaves (the WMAP haze) and polarized radio waves. We use ultraviolet absorption-line spectra from the Hubble Space Telescope to constrain the velocity of the outflowing gas within these regions, targeting the quasar PDS 456 (Galactic coordinates l,b=10.4, +11.2 degrees). This sightline passes through a clear biconical structure seen in hard X-ray and gamma-ray emission near the base of the northern Fermi Bubble. We report two high-velocity metal absorption components, at v_LSR=-235 and +250 km/s, which cannot be explained by co-rotating gas in the Galactic disk or halo. Their velocities are suggestive of an origin on the front and back side of an expanding biconical outflow emanating from the Galactic Center. We develop simple kinematic biconical outflow models that can explain these observed profiles with an outflow velocity of ~900 km/s and a full opening angle of ~110 degrees (matching the X-ray bicone). This indicates Galactic Center activity over the last ~2.5-4.0 Myr, in line with age estimates of the Fermi Bubbles. The observations illustrate the use of UV absorption-line spectroscopy to probe the properties of swept-up gas venting into the Fermi Bubbles., Comment: ApJ Letters, accepted, 6 pages, 3 figures, 1 table, updated from previous version with minor comments to match published version

Published
2014
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44. Guideline-based indicators for adult patients with myelodysplastic syndromes

Author

Stojkov, Kristina, Silzle, Tobias, Stussi, Georg, Schwappach, David, Bernhard, Juerg, Bowen, David, Čermák, Jaroslav, Dinmohamed, Avinash G., Eeltink, Corien, Eggmann, Sabrina, Fenaux, Pierre, Germing, Ulrich, Haschke, Manuel, Hellstrom-Lindberg, Eva, Heger, Monika, van de Loosdrecht, Arjan A., Passweg, Jakob, Pfeilstöcker, Michael, Platzbecker, Uwe, Malcovati, Luca, de Almeida, António Medina, Mittelman, Moshe, Morgenthaler, Christine, Steensma, David P., Santini, Valeria, Stauder, Reinhard, Symeonidis, Argiris, Schär, Sämi, Maddox, Charlotte, de Witte, Theo, Bohlius, Julia, and Bonadies, Nicolas

Published
2020
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45. Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts

Author

Zeidan, Amer M, Boddu, Prajwal C, Patnaik, Mrinal M, Bewersdorf, Jan Philipp, Stahl, Maximilian, Rampal, Raajit K, Shallis, Rory, Steensma, David P, Savona, Michael R, Sekeres, Mikkael A, Roboz, Gail J, DeAngelo, Daniel J, Schuh, Andre C, Padron, Eric, Zeidner, Joshua F, Walter, Roland B, Onida, Francesco, Fathi, Amir, DeZern, Amy, Hobbs, Gabriela, Stein, Eytan M, Vyas, Paresh, Wei, Andrew H, Bowen, David T, Montesinos, Pau, Griffiths, Elizabeth A, Verma, Amit K, Keyzner, Alla, Bar-Natan, Michal, Navada, Shyamala C, Kremyanskaya, Marina, Goldberg, Aaron D, Al-Kali, Aref, Heaney, Mark L, Nazha, Aziz, Salman, Huda, Luger, Selina, Pratz, Keith W, Konig, Heiko, Komrokji, Rami, Deininger, Michael, Cirici, Blanca Xicoy, Bhatt, Vijaya Raj, Silverman, Lewis R, Erba, Harry P, Fenaux, Pierre, Platzbecker, Uwe, Santini, Valeria, Wang, Eunice S, Tallman, Martin S, Stone, Richard M, and Mascarenhas, John

Published
2020
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48. Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Results of a pilot randomized trial RBC‐ENHANCE

Author

Buckstein, Rena, primary, Callum, Jeannie, additional, Prica, Anca, additional, Bowen, David, additional, Wells, Richard A., additional, Leber, Brian, additional, Heddle, Nancy, additional, Chodirker, Lisa, additional, Cheung, Matthew, additional, Mozessohn, Lee, additional, Yee, Karen, additional, Gallagher, Jennifer, additional, Parmentier, Anne, additional, Jamula, Erin, additional, Zhang, Liying, additional, Mamedov, Alex, additional, Stanworth, Simon J., additional, and Lin, Yulia, additional

Published
2024
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49. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, 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additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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50. Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Combined results from two randomized controlled feasibility studies

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Buckstein, Rena, primary, Callum, Jeannie, additional, Prica, Anca, additional, Bowen, David, additional, Wells, Richard A., additional, Leber, Brian, additional, Heddle, Nancy, additional, Chodirker, Lisa, additional, Cheung, Matthew, additional, Mozessohn, Lee, additional, Yee, Karen, additional, Gallagher, Jennifer, additional, Parmentier, Anne, additional, Jamula, Erin, additional, McQuilten, Zoe, additional, Wood, Erica M., additional, Weinkov, Robert, additional, Zhang, Liying, additional, Mamedov, Alex, additional, Stanworth, Simon J., additional, and Lin, Yulia, additional

Published
2023
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