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115 results on '"Bowman, Alex"'

1. Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Author

Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris‑Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao‑Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., and Cookson, William O. C. M.

Published
2022
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2. Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Author

Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris-Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao-Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., and Cookson, William O. C. M.

Published
2021
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6. Birds of prey are well aware of glowing mice

Author

Bowman, Alex

Subjects
Business, Science and technology
Abstract

1 April, p 11 From Alex Bowman, Glasgow, UK Researchers aren't the first living beings to notice that an ultraviolet glow can betray the presence of small animals such as [...]

Published
2023

7. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Author

Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, Watkins, Thomas B. K., McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grnroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Turajlic, Samra, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Hafez, Dina, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Marie Quinn, Anne, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., Swanton, Charles, Bosshard-Carter, Leticia, Goh, Gerald, Gorman, Pat, Murugaesu, Nirupa, Hynds, Robert E., Horswell, Stuart, Bakir, Maise Al, Mitter, Richard, Escudero, Mickael, Xu, Hang, Goldman, Jacki, Stone, Richard Kevin, Denner, Tamara, Biggs, Jennifer, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Nye, Emma, Graca, Sofia, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Georgiou, Andy, Simeon, Celia, Hector, Gemma, Smith, Amy, Aranda, Marie, Novelli, Marco, Papadatos-Pastos, Dionysis, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Taylor, Magali, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturvedi, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Rogan, Jane, Smith, Elaine, Tugwood, Jonathan, Brady, Ged, Rothwell, Dominic G., Chemi, Francesca, Pierce, Jackie, Gulati, Sakshi, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Djearaman, Madava, Quesne, John Le, Thomas, Anne, Walter, Harriet, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Primrose, Lindsay, Amadi, Anita, Palmer, Shirley, Miller, Joy, Buchan, Keith, Edwards, Alison, Morgan, Fiona, Verjee, Azmina, MacKenzie, Mairead, Wilcox, Maggie, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Barbosa, Monica Tavares, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Ronquillo, John Carlo, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Nicholson, Andrew G., Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Light, Teresa, Horey, Tracey, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Fisher, Patricia, Keerio, Allah Dino, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Dentro, Stefan, and Dessimoz, Christophe

Subjects
Lung cancer -- Genetic aspects -- Development and progression, DNA sequencing -- Methods, Phylogeny -- Observations, Cancer metastasis -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies., Author(s): Christopher Abbosh [1]; Nicolai J. Birkbak [1, 2]; Gareth A. Wilson [1, 2]; Mariam Jamal-Hanjani [1]; Tudor Constantin [3]; Raheleh Salari [3]; John Le Quesne [4]; David A. Moore [...]

Published
2017
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13. PD60-09 DISPARITIES IN PRE-ORCHIECTOMY SPERM CRYOPRESERVATION AMONG TESTICULAR CANCER PATIENTS AT A PUBLIC SAFETY NET HOSPITAL AND A PRIVATE TERTIARY CARE CENTER

Author

Patel, Akshat, primary, Howard, Jeffrey M, additional, Chertack, Nathan, additional, Margulis, Vitaly, additional, Woldu, Solomon, additional, Courtney, Kevin, additional, Bowman, Alex, additional, Arafat, Waddah, additional, Meng, Xiaosong, additional, Bakare, Tolulope, additional, and Bagrodia, Aditya, additional

Published
2021
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14. Genomic mapping identifies multiple therapeutic pathways in malignant mesothelioma

Author

Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris-Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao-Ming, Gennatas, Spyridon, Rintoul, Robert C, Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Newman Taylor, Anthony, Nicholson, Andrew G, Popat, Sanjay, Willis, Anne E, MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M, Moffatt, Miriam F, and Cookson, William OCM

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive malignancy associated with asbestos exposure. It shows limited responses to all treatments. Although 20% of tumours may transiently regress after checkpoint immunotherapy, predictors of response are unknown. The molecular landscape is of low complexity but recurrent lesions have not yet defined effective therapeutic targets. In order to comprehensively map genomic alterations, we combined copy-number analysis from SNP arrays with targeted sequencing of tumours from 121 patients. We found previously unrecognised deletions in the tumour suppressor RB1 in 26% of cases. These combined with CDKN2A and TP53 lesions affected the RB tumour suppressor pathway in 65% of tumours. We show here therapeutic avenues downstream of RB1 by finding micromolar half maximal inhibitory concentrations (IC50s) of PLK1, CHEK1 and Aurora Kinase inhibitors in MPM cell lines. Non-overlapping defects in Hippo pathways ( RASSF7 amplification, NF2 , LATS1 and LATS2 mutations) were present in 48% of tumours, accompanied by micromolar IC50s to the YAP1 inhibitor Verteporfin. Loss of a 240Kb locus containing SUFU was observed in 21% of tumours, accompanied by disordered expression of Hedgehog pathway genes. SUFU depletion was reproducibly associated with reduced transcription of T-cell and macrophage regulators, and increased transcription of the immune checkpoint inhibitor VISTA. In half of all MPM, CDKN2A deletions were accompanied by loss of Interferon Type I genes. The presence of dysregulated Hedgehog immune transcription and loss of Type I Interferons indicate novel approaches to immunotherapy.

Published
2020
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16. Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma

Author

Yaseen, Bodoor, primary, Lopez, Henry, additional, Taki, Zeinab, additional, Zafar, Sara, additional, Rosario, Henrique, additional, Abdi, Bahja Ahmed, additional, Vigneswaran, Shivanee, additional, Xing, Fiona, additional, Arumalla, Nikita, additional, Black, Simon, additional, Ahmad, Sara, additional, Kumar, Kimti, additional, Gul, Rabia, additional, Scolamiero, Laura, additional, Morris, Sian, additional, Bowman, Alex, additional, Stainer, Anna, additional, Rice, Alexandra, additional, Stock, Carmel, additional, Renzoni, Elisabetta, additional, Denton, Christopher P, additional, Venturini, Cristina, additional, Brown, Max, additional, O’Reilly, Steven, additional, and Stratton, Richard, additional

Published
2020
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19. Integrated genomics identify novel immunotherapy targets for malignant mesothelioma

Author

Nastase, Anca, primary, Mandal, Amit, additional, Lu, Shir Kiong, additional, Anbunathan, Hima, additional, Morris-Rosendahl, Deborah, additional, Zhang, Yu Zhi, additional, Sun, Xiao-Ming, additional, Gennatas, Spyridon, additional, Rintoul, Robert C, additional, Edwards, Matthew, additional, Bowman, Alex, additional, Chernova, Tatyana, additional, Benepal, Tim, additional, Lim, Eric, additional, Taylor, Anthony Newman, additional, Nicholson, Andrew G, additional, Popat, Sanjay, additional, Willis, Anne E, additional, MacFarlane, Marion, additional, Lathrop, Mark, additional, Bowcock, Anne M, additional, Moffatt, Miriam F, additional, and Cookson, William OCM, additional

Published
2020
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21. Police beat: stolen backpacks, a fight, and counterfeit money

Author

Bowman, Alex

Subjects
Theft, Backpacks, Reason, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Car doors have a lock for a reason On Feb. 18, a UPD officer was dispatched to meet with a UNF student in reference to [...]

Published
2020

22. Why should you file taxes?

Author

Bowman, Alex

Subjects
Tax administration, Taxation, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Tax season is upon us, and you might be asking yourself should I pay my taxes? It's a tedious and frustrating process, but here are [...]

Published
2020

23. Police beat: strange man in the President's Office

Author

Bowman, Alex

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter On Tuesday morning, two UPD officers were dispatched to Building 1, room 2800 in reference to a Middle Eastern male suspiciously trying to leave a [...]

Published
2020

24. What do the new immigration rules mean?

Author

Echevarria, Emily and Bowman, Alex

Subjects
Immigration law, Emigration and immigration, Medicaid, Immigrants, Retirement benefits, Company business planning, News, opinion and commentary, Sports and fitness
Abstract

Byline: Emily Echevarria and Alex Bowman In a 5-4 decision, the Supreme Court ruled that the Trump administration would be allowed to move forward with its plan to implement new [...]

Published
2020

25. 'The Office! A Musical Parody' is coming to theatres near you

Author

Bowman, Alex

Subjects
Documentary movies, Paper industry, Musical theater, Workers, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter 'It's a typical morning at Scranton's third largest paper company until, for no logical reason, a documentary crew begins filming the lives of the employees [...]

Published
2020

27. Police beat 1/16: razor blades and a damaged TV

Author

Bowman, Alex

Subjects
Razors, Libraries, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Damaged Library TV Tuesday afternoon, a UPD officer was dispatched to the UNF Carpenter Library in reference to a damaged TV on the second floor. [...]

Published
2020

28. OneJax named lead partner and facilitator of anti-neo-Nazi task force

Author

Bowman, Alex

Subjects
Neo-Nazis, Anti-Nazi movements, Task forces, Vandalism, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Last semester, UNF had multiple incidents involving neo-Nazi posters and other propoganda found on campus. After an instance of vandalism involving swastika imagery, President David [...]

Published
2020

29. Police beat 1/8: new year, new police beats

Author

Bowman, Alex

Subjects
Company legal issue, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Drunk before 6 p.m. Late Tuesday afternoon, a UPD officer responded to a call about a woman who was passed out in the dirt face [...]

Published
2020

30. UNF Women's Center hosts annual Celebration of Women in Arts

Author

Bowman, Alex

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter The Celebration of Women in the Arts is a variety show featuring local, woman-centered talent and has been annual event since 1987. Last night was [...]

Published
2020

32. Your letters.

Author

Welsby, Philip, McCormick, tim, Györy, Steph, Menon, Gautam, Hull, Roger, Sweeney, Anne, Wilkins, Diana, Osen, Adam, and Bowman, Alex

Subjects
GAMMA ray bursts, CLIMATE change
Abstract

The main difficulty in building quantum computers is how to maintain the quantum state (another name for wave function) through multiple quantum gates - which do the processing - for long enough to do something useful. How to get to grips with conspiracy theories 15 April, p 12 From Philip Welsby, Edinburgh, UK It seems that conspiracy theories are very hard to counter, the problem being that it is difficult to change people's minds. No need to worry about the quantum observer 8 April, p 36 From Roger Hull, Craigellachie, Moray, UK The idea that a conscious being is needed to collapse the quantum wave function, which describes the probability that a particle will behave a certain way, has been abandoned by most physicists. [Extracted from the article]

Published
2023

33. Your letters.

Author

Nelson, Dawn, Riddlestone, Dave, Valdar, Susan, Warburton, Gary, Hockley, Vernon, Beaumont, HildaRuth, Shead, Andrew, Bowman, Alex, Smit, Ton, and Eymann, Markus

Subjects
GROUND source heat pump systems, CATS
Abstract

I have noticed that cats seem to only have this sort of bond with one particular person, which is different to the human-dog dynamic and may explain the perception by non-owners that cats are less sociable than dogs. Regarding the test on whether your cat can read your gaze, our cat Bertie understands the concept of following human gaze. Editor's pick On the true nature of the house cat 11 March, p 46 From Dawn Nelson, Greenwood, Maine, US Many people discount the idea that cats can have emotional bonds with humans. [Extracted from the article]

Published
2023

34. Fc effector function contributes to the activity of human anti-CTLA-4 antibodies

Author

Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., Quezada, Sergio A., Harrington, Kevin, Melcher, Alan, Wotherspoon, Andrew, Francis, Nicholas, Challacombe, Ben, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Lynch, Joanna, Rudman, Sarah, Chowdhury, Simon, Harrison-Phipps, Karen, Varia, Mary, Horsfield, Catherine, Polson, Alexander, Stamp, Gordon, O'Donnell, Marie, Drake, William, Hill, Peter, Hrouda, David, Mayer, Eric, Olsburgh, Jonathan, Kooiman, Gordon, O'Connor, Kevin, Stewart, Grant, Aitchison, Michael, Tran, Maxine, Fotiadis, Nicos, Verma, Hema, Lopez, Jose, Lester, Jason, Morgan, Fiona, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Fennell, Dean, Shaw, Jacqui, Le Quesne, John, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lock, Sara, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Novasio, Juliette, Joseph, Leena, Bishop, Paul, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Rothwell, Dominic, Gulati, Sakshi, Chemie, Francesca, Tugwood, Jonathan, Pierce, Jackie, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, George, Robert, Patrini, Davide, Falzon, Mary, Borg, Elaine, Khiroya, Reena, Jamal-Hanjani, Mariam, Wilson, Gareth, Juul Birkbak, Nicolai, Watkins, Thomas, McGranahan, Nicholas, Abbosh, Christopher, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Rowan, Andrew, Hiley, Crispin, Goldman, Jacki, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Shaw, Penny, Veeriah, Raju, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Hynds, Robert, Werner Sunderland, Mariana, Reading, James, Novelli, Marco, Oukrif, Dahmane, Janes, Sam, Forster, Martin, Ahmad, Tanya, Ming Lee, Siow, van Loo, Peter, Herrero, Javier, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Ward, Sophie, Elgar, Greg, Al-Bakir, Maise, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Papadatos-Pastos, Dionysis, Scarci, Marco, Gorman, Pat, Lowe, Helen, Ensell, Leah, Moore, David, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Tavares Barbosa, Monica, Nicholson, Andrew, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Elena Cufari, Maria, Carlo Ronquillo, John, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Prakash, Vineet, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Russell, Peter, Light, Teresa, Horey, Tracey, Blyth, Kevin, Dick, Craig, and Kirk, Alan

Abstract

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F high affinity polymorphism. Such activity only appeared relevant in the context of inflamed tumors, explaining the modest response rates observed in the clinical setting. Our data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches.

Published
2018

37. UPD offers some holiday safety tips

Author

Bowman, Alex

Subjects
Accidental falls, Theft, Crime, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Winter break is just around the corner, and with the holidays upon us, crime rates are subject to increase. With this in mind, Spinnaker talked [...]

Published
2019

38. Police beat: swastika graffiti, snack thief, and golf cart vs. light pole

Author

Bowman, Alex

Subjects
Snack foods, Golf carts, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter 'F*ck UNF - and' Someone has some strong feelings about UNF. Earlier this week, a UNFPD officer was dispatched to Building 2 in reference to [...]

Published
2019

39. What you should know about cybersecurity during the holiday season

Author

Bowman, Alex

Subjects
Data security, Consumer education, Internet fraud, Internet security, Computer hackers, Cyberterrorism, Retail trade, Fraud, Online shopping, Internet security, Data security issue, Hacker, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Retailers and shoppers beware... The holiday season is officially upon us and just like every holiday season, people will be shopping much more than they [...]

Published
2019

41. Wells Fargo is dropping late fees for student loans

Author

Bowman, Alex

Subjects
Wells Fargo & Co., Student loans, Fees, Banking industry, Legal fees, Banking industry, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter If you're a Wells Fargo customer and you've logged into your account online or in the mobile app recently, you might have seen the following [...]

Published
2019

42. Put the 'give' in Thanksgiving this season!

Author

Bowman, Alex

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter It's the season to give thanks and give a little something back. With Thanksgiving coming up, some people might be looking to volunteer, but where [...]

Published
2019

43. Check your time tickets!

Author

Bowman, Alex

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter With the semester coming to an end, most students are preparing to register for the Spring semester, but when can you register? UNF released the [...]

Published
2019

44. Swoop on in for Avengers: Endgame

Author

Bowman, Alex

Subjects
Snack foods, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Tonight, Osprey Life and Productions is showing 'Avengers: Endgame' at the UNF Coxwell Amphitheater. The event runs from 7 p.m. to 10 p.m. This event [...]

Published
2019

45. Police beat: stolen bikes, masked men, missing signs

Author

Bowman, Alex

Subjects
Theft, Parking lots, Intelligence gathering, News, opinion and commentary, Sports and fitness, Snapchat (Online social network)
Abstract

Byline: Alex Bowman, Police Reporter The culprit pedals away in this one. On Oct. 26, a UNF student's bike was stolen, according to a police report. The student met with [...]

Published
2019

46. Police beat: another stolen skateboard, violence between roommates, vehicle damage

Author

Bowman, Alex

Subjects
Theft, Violence, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Another skateboard theft What's scarier than the spooks this week? Skateboard theft. A student's skateboard was stolen from the racks outside the Osprey Cafe after [...]

Published
2019

47. Swoop up the bucks: Federal Work Study offers new jobs for UNF students

Author

Bowman, Alex

Subjects
Student employment, Job hunting, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter If you qualify for the Federal Work Study program and are looking for a new job, there have been some new openings here at UNF [...]

Published
2019

48. Missed Battle of the Bands? Here's a recap

Author

Bowman, Alex

Subjects
Musical groups, Citrus, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Jason Tidman, also known as 'Tiddy,' a Jax-based DJ, won the first ever Battle of the Bands this past Friday night and will be the [...]

Published
2019

49. Spooky movies to stream

Author

Bowman, Alex and Reporter, Police

Subjects
Corn, Video recordings, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter It's spooky season again, and if you have free time, you might be interested in watching a spooky movie. However, in today's digital world, very [...]

Published
2019

50. Music? Food? Check out Battle of the Bands

Author

Bowman, Alex and Reporter, Police

Subjects
Musical groups, News, opinion and commentary, Sports and fitness
Abstract

Byline: Alex Bowman, Police Reporter Do you love free music? What about free food? If you answered yes to either of those questions, you should check out Osprey Productions' Battle [...]

Published
2019

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