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8 results on '"Bowman, Cindy M."'

1. Immune checkpoint modulation enhances HIV-1 antibody induction

Author

Bradley, Todd, Kuraoka, Masayuki, Yeh, Chen-Hao, Tian, Ming, Chen, Huan, Cain, Derek W., Chen, Xuejun, Cheng, Cheng, Ellebedy, Ali H., Parks, Robert, Barr, Maggie, Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Bouton-Verville, Hilary, Santra, Sampa, Wiehe, Kevin, Lewis, Mark G., Ogbe, Ane, Borrow, Persephone, Montefiori, David, Bonsignori, Mattia, Anthony Moody, M., Verkoczy, Laurent, Saunders, Kevin O., Ahmed, Rafi, Mascola, John R., Kelsoe, Garnett, Alt, Frederick W., and Haynes, Barton F.

Published
2020
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2. HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques

Author

Han, Qifeng, primary, Williams, Wilton B., additional, Saunders, Kevin O., additional, Seaton, Kelly E., additional, Wiehe, Kevin J., additional, Vandergrift, Nathan, additional, Von Holle, Tarra A., additional, Trama, Ashley M., additional, Parks, Robert J., additional, Luo, Kan, additional, Gurley, Thaddeus C., additional, Kepler, Thomas B., additional, Marshall, Dawn J., additional, Montefiori, David C., additional, Sutherland, Laura L., additional, Alam, Munir S., additional, Whitesides, John F., additional, Bowman, Cindy M., additional, Permar, Sallie R., additional, Graham, Barney S., additional, Mascola, John R., additional, Seed, Patrick C., additional, Van Rompay, Koen K. A., additional, Tomaras, Georgia D., additional, Moody, M. Anthony, additional, and Haynes, Barton F., additional

Published
2017
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3. Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice

Author

Wiehe, Kevin, primary, Nicely, Nathan I., additional, Lockwood, Bradley, additional, Kuraoka, Masayuki, additional, Anasti, Kara, additional, Arora, Sabrina, additional, Bowman, Cindy M., additional, Stolarchuk, Christina, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Xia, Shi-Mao, additional, Duffy, Ryan, additional, Shen, Xiaoying, additional, Kyratsous, Christos A., additional, Macdonald, Lynn E., additional, Murphy, Andrew J., additional, Scearce, Richard M., additional, Moody, M. Anthony, additional, Alam, S. Munir, additional, Verkoczy, Laurent, additional, Tomaras, Georgia D., additional, Kelsoe, Garnett, additional, and Haynes, Barton F., additional

Published
2017
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4. HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism

Author

Bradley, Todd, primary, Yang, Guang, additional, Ilkayeva, Olga, additional, Holl, T. Matt, additional, Zhang, Ruijun, additional, Zhang, Jinsong, additional, Santra, Sampa, additional, Fox, Christopher B., additional, Reed, Steve G., additional, Parks, Robert, additional, Bowman, Cindy M., additional, Bouton-Verville, Hilary, additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Vandergrift, Nathan, additional, Kepler, Thomas B., additional, Moody, M. Anthony, additional, Liao, Hua-Xin, additional, Alam, S. Munir, additional, McLendon, Roger, additional, Everitt, Jeffrey I., additional, Newgard, Christopher B., additional, Verkoczy, Laurent, additional, Kelsoe, Garnett, additional, and Haynes, Barton F., additional

Published
2016
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5. Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques

Author

Luo, Kan, primary, Liao, Hua-Xin, additional, Zhang, Ruijun, additional, Easterhoff, David, additional, Wiehe, Kevin, additional, Gurley, Thaddeus C., additional, Armand, Lawrence C., additional, Allen, Ashley A., additional, Von Holle, Tarra A., additional, Marshall, Dawn J., additional, Whitesides, John F., additional, Pritchett, Jamie, additional, Foulger, Andrew, additional, Hernandez, Giovanna, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Stolarchuk, Christina, additional, Sawant, Sheetal, additional, Peel, Jessica, additional, Yates, Nicole L., additional, Dunford, Erika, additional, Arora, Sabrina, additional, Wang, Amy, additional, Bowman, Cindy M., additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Xia, Shi-Mao, additional, Bonsignori, Mattia, additional, Pollara, Justin, additional, Edwards, R. Whitney, additional, Santra, Sampa, additional, Letvin, Norman L., additional, Tartaglia, James, additional, Francis, Donald, additional, Sinangil, Faruk, additional, Lee, Carter, additional, Kaewkungwal, Jaranit, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Rerks-ngarm, Supachai, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Alam, S. Munir, additional, Vandergrift, Nathan A., additional, Ferrari, Guido, additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Haynes, Barton F., additional, and Moody, M. Anthony, additional

Published
2016
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6. Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity

Author

Bradley, Todd, primary, Trama, Ashley, additional, Tumba, Nancy, additional, Gray, Elin, additional, Lu, Xiaozhi, additional, Madani, Navid, additional, Jahanbakhsh, Fatemeh, additional, Eaton, Amanda, additional, Xia, Shi-Mao, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Bowman, Cindy M., additional, Barnett, Susan, additional, Abdool-Karim, Salim S., additional, Boyd, Scott D., additional, Melillo, Bruno, additional, Smith, Amos B., additional, Sodroski, Joseph, additional, Kepler, Thomas B., additional, Alam, S.Munir, additional, Gao, Feng, additional, Bonsignori, Mattia, additional, Liao, Hua-Xin, additional, Moody, M. Anthony, additional, Montefiori, David, additional, Santra, Sampa, additional, Morris, Lynn, additional, and Haynes, Barton F., additional

Published
2016
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7. Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

Author

Bradley, Todd, primary, Fera, Daniela, additional, Bhiman, Jinal, additional, Eslamizar, Leila, additional, Lu, Xiaozhi, additional, Anasti, Kara, additional, Zhang, Ruijung, additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Bowman, Cindy M., additional, Stolarchuk, Christina, additional, Lloyd, Krissey E., additional, Parks, Robert, additional, Eaton, Amanda, additional, Foulger, Andrew, additional, Nie, Xiaoyan, additional, Karim, Salim S. Abdool, additional, Barnett, Susan, additional, Kelsoe, Garnett, additional, Kepler, Thomas B., additional, Alam, S. Munir, additional, Montefiori, David C., additional, Moody, M. Anthony, additional, Liao, Hua-Xin, additional, Morris, Lynn, additional, Santra, Sampa, additional, Harrison, Stephen C., additional, and Haynes, Barton F., additional

Published
2016
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8. HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques.

Author

Qifeng Han, Williams, Wilton B., Saunders, Kevin O., Seaton, Kelly E., Wiehe, Kevin J., Vandergrift, Nathan, Von Holle, Tarra A., Trama, Ashley M., Parks, Robert J., Kan Luo, Gurley, Thaddeus C., Kepler, Thomas B., Marshall, Dawn J., Montefiori, David C., Sutherland, Laura L., Alam, Munir S., Whitesides, John F., Bowman, Cindy M., Permar, Sallie R., and Graham, Barney S.

Subjects
*ADENOVIRUS diseases, *VACCINES, *HIV, *RHESUS monkeys, *IMMUNIZATION
Abstract

Dominant antibody responses in vaccinees who received the HIV-1 multiclade (A, B, and C) envelope (Env) DNA/recombinant adenovirus virus type 5 (rAd5) vaccine studied in HIV-1 Vaccine Trials Network (HVTN) efficacy trial 505 (HVTN 505) targeted Env gp41 and cross-reacted with microbial antigens. In this study, we asked if the DNA/rAd5 vaccine induced a similar antibody response in rhesus macaques (RMs), which are commonly used as an animal model for human HIV-1 infections and for testing candidate HIV-1 vaccines. We also asked if gp41 immunodominance could be avoided by immunization of neonatal RMs during the early stages of microbial colonization. We found that the DNA/rAd5 vaccine elicited a higher frequency of gp41-reactive memory B cells than gp120-memory B cells in adult and neonatal RMs. Analysis of the vaccine-induced Env-reactive B cell repertoire revealed that the majority of HIV-1 Env-reactive antibodies in both adult and neonatal RMs were targeted to gp41. Interestingly, a subset of gp41-reactive antibodies isolated from RMs cross-reacted with host antigens, including autologous intestinal microbiota. Thus, gp41-containing DNA/rAd5 vaccine induced dominant gp41-microbiota cross-reactive antibodies derived from blood memory B cells in RMs as observed in the HVTN 505 vaccine efficacy trial. These data demonstrated that RMs can be used to investigate gp41 immunodominance in candidate HIV-1 vaccines. Moreover, colonization of neonatal RMs occurred within the first week of life, and immunization of neonatal RMs during this time also induced a dominant gp41-reactive antibody response. [ABSTRACT FROM AUTHOR]

Published
2017
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