Search

Your search keyword '"Bowman-Kirigin, Jay A."' showing total 20 results
Start Over Author "Bowman-Kirigin, Jay A."
20 results on '"Bowman-Kirigin, Jay A."'

1. Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Author

Wang, Anthony Z., Bowman-Kirigin, Jay A., Desai, Rupen, Kang, Liang-I, Patel, Pujan R., Patel, Bhuvic, Khan, Saad M., Bender, Diane, Marlin, M. Caleb, Liu, Jingxian, Osbun, Joshua W., Leuthardt, Eric C., Chicoine, Michael R., Dacey, Jr, Ralph G., Zipfel, Gregory J., Kim, Albert H., DeNardo, David G., Petti, Allegra A., and Dunn, Gavin P.

Published
2022
Full Text
View/download PDF

2. Supplementary Data from The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain

Author

Bowman-Kirigin, Jay A., primary, Desai, Rupen, primary, Saunders, Brian T., primary, Wang, Anthony Z., primary, Schaettler, Maximilian O., primary, Liu, Connor J., primary, Livingstone, Alexandra J., primary, Kobayashi, Dale K., primary, Durai, Vivek, primary, Kretzer, Nicole M., primary, Zipfel, Gregory J., primary, Leuthardt, Eric C., primary, Osbun, Joshua W., primary, Chicoine, Michael R., primary, Kim, Albert H., primary, Murphy, Kenneth M., primary, Johanns, Tanner M., primary, Zinselmeyer, Bernd H., primary, and Dunn, Gavin P., primary

Published
2023
Full Text
View/download PDF

3. Data from The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain

Author

Bowman-Kirigin, Jay A., primary, Desai, Rupen, primary, Saunders, Brian T., primary, Wang, Anthony Z., primary, Schaettler, Maximilian O., primary, Liu, Connor J., primary, Livingstone, Alexandra J., primary, Kobayashi, Dale K., primary, Durai, Vivek, primary, Kretzer, Nicole M., primary, Zipfel, Gregory J., primary, Leuthardt, Eric C., primary, Osbun, Joshua W., primary, Chicoine, Michael R., primary, Kim, Albert H., primary, Murphy, Kenneth M., primary, Johanns, Tanner M., primary, Zinselmeyer, Bernd H., primary, and Dunn, Gavin P., primary

Published
2023
Full Text
View/download PDF

5. TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma

Author

Schaettler, Maximilian O, primary, Desai, Rupen, additional, Wang, Anthony Z, additional, Livingstone, Alexandra J, additional, Kobayashi, Dale K, additional, Coxon, Andrew T, additional, Bowman-Kirigin, Jay A, additional, Liu, Connor J, additional, Li, Mao, additional, Bender, Diane E, additional, White, Michael J, additional, Kranz, David M, additional, Johanns, Tanner M, additional, and Dunn, Gavin P, additional

Published
2023
Full Text
View/download PDF

6. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain

Author

Bowman-Kirigin, Jay A., primary, Desai, Rupen, additional, Saunders, Brian T., additional, Wang, Anthony Z., additional, Schaettler, Maximilian O., additional, Liu, Connor J., additional, Livingstone, Alexandra J., additional, Kobayashi, Dale K., additional, Durai, Vivek, additional, Kretzer, Nicole M., additional, Zipfel, Gregory J., additional, Leuthardt, Eric C., additional, Osbun, Joshua W., additional, Chicoine, Michael R., additional, Kim, Albert H., additional, Murphy, Kenneth M., additional, Johanns, Tanner M., additional, Zinselmeyer, Bernd H., additional, and Dunn, Gavin P., additional

Published
2022
Full Text
View/download PDF

8. Additional file 1 of Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Author

Wang, Anthony Z., Bowman-Kirigin, Jay A., Desai, Rupen, Kang, Liang-I, Patel, Pujan R., Patel, Bhuvic, Khan, Saad M., Bender, Diane, Marlin, M. Caleb, Liu, Jingxian, Osbun, Joshua W., Leuthardt, Eric C., Chicoine, Michael R., Dacey, Ralph G., Zipfel, Gregory J., Kim, Albert H., DeNardo, David G., Petti, Allegra A., and Dunn, Gavin P.

Abstract

Additional file 1: Figs. S1-S8, Tables S1-S4. Fig. S1. Analysis of human dura immune cells and comparison to murine dura immune cells. Fig. S2. Leptomeningeal fibroblast markers. Fig. S3. Imaging mass cytometry of CD11b+ GZMB+ immune cells in DURA02 and DURA05. Fig. S4. Gene markers for PTPRC+ cells in dura and tumor samples. Fig. S5. Immunohistochemistry of a matched pair of non-tumor-associated dura and tumor. Fig. S6. Quantification of TCR overlap. Fig. S7. Analysis of DURA09, MEN09, MEN104, and MEN108 samples differentiated by general cell types. Fig. S8. CONICSmat analysis of putative patient specific tumor cells. Table S1. Patient demographics and sample characteristics. Table S2. Gene markers for cell type identification. Table S3. Antibody Information. Table S4. Gene markers for macrophage polarization states.

Published
2022
Full Text
View/download PDF

9. The conventional dendritic cell 1 subset primes CD8+ T cells and traffics tumor antigen to drive anti-tumor immunity in the brain

Author

Bowman-Kirigin, Jay A., primary, Saunders, Brian T., additional, Desai, Rupen, additional, Wang, Anthony Z., additional, Schaettler, Max O., additional, Liu, Connor J., additional, Livingstone, Alexandra J., additional, Kobayashi, Dale K., additional, Durai, Vivek, additional, Kretzer, Nicole M., additional, Zipfel, Gregory J., additional, Leuthardt, Eric C., additional, Osbun, Joshua W., additional, Chicoine, Michael R., additional, Kim, Albert H., additional, Murphy, Kenneth M., additional, Johanns, Tanner M., additional, Zinselmeyer, Bernd H., additional, and Dunn, Gavin P., additional

Published
2021
Full Text
View/download PDF

10. Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

Author

Wang, Anthony Z., primary, Bowman-Kirigin, Jay A., additional, Desai, Rupen, additional, Patel, Pujan R., additional, Patel, Bhuvic, additional, Khan, Saad M., additional, Bender, Diane, additional, Marlin, M. Caleb, additional, Liu, Jingxian, additional, Osbun, Joshua W., additional, Leuthardt, Eric C., additional, Chicoine, Michael R., additional, Dacey, Ralph G., additional, Zipfel, Gregory J., additional, Kim, Albert H., additional, Petti, Allegra A., additional, and Dunn, Gavin P., additional

Published
2021
Full Text
View/download PDF

11. IMMU-26. UNRAVELING ANTIGEN PRESENTATION IN CENTRAL NERVOUS SYSTEM ANTI-TUMOR IMMUNITY

Author

Bowman-Kirigin, Jay, primary, Kobayashi, Dale, additional, Livingstone, Alexandra, additional, Saunders, Brian, additional, Schaettler, Max, additional, Liu, Connor, additional, Durai, Vivek, additional, Bowman-Kirigin, Jay, additional, Leuthardt, Eric, additional, Kim, Albert, additional, Zipfel, Gregory, additional, Osbun, Joshua, additional, Chicoine, Michael, additional, Murphy, Kenneth, additional, Zinselmeyer, Bernd, additional, Johanns, Tanner, additional, and Dunn, Gavin, additional

Published
2020
Full Text
View/download PDF

12. Treatment of an aggressive orthotopic murine glioblastoma model with combination checkpoint blockade and a multivalent neoantigen vaccine

Author

Liu, Connor J, primary, Schaettler, Maximilian, additional, Blaha, Dylan T, additional, Bowman-Kirigin, Jay A, additional, Kobayashi, Dale K, additional, Livingstone, Alexandra J, additional, Bender, Diane, additional, Miller, Christopher A, additional, Kranz, David M, additional, Johanns, Tanner M, additional, and Dunn, Gavin P, additional

Published
2020
Full Text
View/download PDF

17. Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation

Author

Gibson, Christopher C., primary, Zhu, Weiquan, additional, Davis, Chadwick T., additional, Bowman-Kirigin, Jay A., additional, Chan, Aubrey C., additional, Ling, Jing, additional, Walker, Ashley E., additional, Goitre, Luca, additional, Delle Monache, Simona, additional, Retta, Saverio Francesco, additional, Shiu, Yan-Ting E., additional, Grossmann, Allie H., additional, Thomas, Kirk R., additional, Donato, Anthony J., additional, Lesniewski, Lisa A., additional, Whitehead, Kevin J., additional, and Li, Dean Y., additional

Published
2015
Full Text
View/download PDF

20. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain.

Author

Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, and Dunn GP

Subjects
Animals, Mice, CD8-Positive T-Lymphocytes, Antigens, Neoplasm, Brain, Dendritic Cells, Neoplasms
Abstract

The central nervous system (CNS) antigen-presenting cell (APC) that primes antitumor CD8+ T-cell responses remains undefined. Elsewhere in the body, the conventional dendritic cell 1 (cDC1) performs this role. However, steady-state brain parenchyma cDC1 are extremely rare; cDCs localize to the choroid plexus and dura. Thus, whether the cDC1 play a function in presenting antigen derived from parenchymal sources in the tumor setting remains unknown. Using preclinical glioblastoma (GBM) models and cDC1-deficient mice, we explored the presently unknown role of cDC1 in CNS antitumor immunity. We determined that, in addition to infiltrating the brain tumor parenchyma itself, cDC1 prime neoantigen-specific CD8+ T cells against brain tumors and mediate checkpoint blockade-induced survival benefit. We observed that cDC, including cDC1, isolated from the tumor, the dura, and the CNS-draining cervical lymph nodes harbored a traceable fluorescent tumor antigen. In patient samples, we observed several APC subsets (including the CD141+ cDC1 equivalent) infiltrating glioblastomas, meningiomas, and dura. In these same APC subsets, we identified a tumor-specific fluorescent metabolite of 5-aminolevulinic acid, which fluorescently labeled tumor cells during fluorescence-guided GBM resection. Together, these data elucidate the specialized behavior of cDC1 and suggest that cDC1 play a significant role in CNS antitumor immunity., (©2022 American Association for Cancer Research.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results