Giga-voxel-resolution computational morphogenesis is used to optimize the internal structure of a full-scale aeroplane wing, yielding light-weight designs with more similarities to animal bone structures than to current aeroplane wing designs. Computational morphogenesis is used to design the best possible shapes and material distributions for the desired structural properties, such as high strength at minimal weight. In plants and animals, morphogenesis occurs naturally through slow genetic evolution. In engineering, a much faster iterative approach for optimum material distribution has been adopted, called topology optimization. So far, it has been used to calculate only small or simple structures owing to limited resolution. Niels Aage et al. have developed a morphogenesis tool that can be run on a supercomputer and can calculate two orders of magnitude more voxels (the three-dimensional equivalents of pixels) than was previously attainable. This makes it possible to design structures with unprecedented detail, yielding new insights into optimal material distribution. The authors calculate an optimized full aircraft wing structure with remarkable structural detail at several length scales, which displays similarities to naturally occurring bone structures such as those seen in bird beaks. The new tool could inspire surprising design approaches for a range of structures, including wind turbine blades, tower masts and bridges. In the design of industrial products ranging from hearing aids to automobiles and aeroplanes, material is distributed so as to maximize the performance and minimize the cost. Historically, human intuition and insight have driven the evolution of mechanical design, recently assisted by computer-aided design approaches. The computer-aided approach known as topology optimization enables unrestricted design freedom and shows great promise with regard to weight savings, but its applicability has so far been limited to the design of single components or simple structures, owing to the resolution limits of current optimization methods1,2. Here we report a computational morphogenesis tool, implemented on a supercomputer, that produces designs with giga-voxel resolution—more than two orders of magnitude higher than previously reported. Such resolution provides insights into the optimal distribution of material within a structure that were hitherto unachievable owing to the challenges of scaling up existing modelling and optimization frameworks. As an example, we apply the tool to the design of the internal structure of a full-scale aeroplane wing. The optimized full-wing design has unprecedented structural detail at length scales ranging from tens of metres to millimetres and, intriguingly, shows remarkable similarity to naturally occurring bone structures in, for example, bird beaks. We estimate that our optimized design corresponds to a reduction in mass of 2–5 per cent compared to currently used aeroplane wing designs, which translates into a reduction in fuel consumption of about 40–200 tonnes per year per aeroplane. Our morphogenesis process is generally applicable, not only to mechanical design, but also to flow systems3, antennas4, nano-optics5 and micro-systems6,7.