Search

Your search keyword '"Boyd, Scott D."' showing total 521 results
Start Over Author "Boyd, Scott D."
521 results on '"Boyd, Scott D."'

2. Cellular and humoral immune response to SARS-CoV-2 vaccination and booster dose in immunosuppressed patients: An observational cohort study

Author

Yang, Lu M, Costales, Cristina, Ramanathan, Muthukumar, Bulterys, Philip L, Murugesan, Kanagavel, Schroers-Martin, Joseph, Alizadeh, Ash A, Boyd, Scott D, Brown, Janice M, Nadeau, Kari C, Nadimpalli, Sruti S, Wang, Aileen X, Busque, Stephan, Pinsky, Benjamin A, and Banaei, Niaz

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Immunization, Infectious Diseases, Prevention, Emerging Infectious Diseases, Vaccine Related, Biodefense, Infection, Good Health and Well Being, Ad26COVS1, Antibodies, Viral, BNT162 Vaccine, COVID-19, COVID-19 Vaccines, Female, Humans, Immunity, Humoral, Immunoglobulin G, Male, Middle Aged, Retrospective Studies, SARS-CoV-2, Vaccination, Viral Vaccines, IGRA, Immunosuppression, Serology, Microbiology, Clinical Sciences, Medical Microbiology, Virology, Clinical sciences, Medical microbiology
Abstract

BackgroundHumoral and cellular immune responses to SARS-CoV-2 vaccination among immunosuppressed patients remain poorly defined, as well as variables associated with poor response.MethodsWe performed a retrospective observational cohort study at a large Northern California healthcare system of infection-naïve individuals fully vaccinated against SARS-CoV-2 (mRNA-1273, BNT162b2, or Ad26.COV2.S) with clinical SARS-CoV-2 interferon gamma release assay (IGRA) ordered between January through November 2021. Humoral and cellular immune responses were measured by anti-SARS-CoV-2 S1 IgG ELISA (anti-S1 IgG) and IGRA, respectively, following primary and/or booster vaccination.Results496 immunosuppressed patients (54% female; median age 50 years) were included. 62% (261/419) of patients had positive anti-S1 IgG and 71% (277/389) had positive IGRA after primary vaccination, with 20% of patients having a positive IGRA only. Following booster, 69% (81/118) had positive anti-S1 IgG and 73% (91/124) had positive IGRA. Factors associated with low humoral response rates after primary vaccination included anti-CD20 monoclonal antibodies (P

Published
2022

3. Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post–COVID-19 syndrome

Author

Jia, Xiaolin, Cao, Shu, Lee, Alexandra S, Manohar, Monali, Sindher, Sayantani B, Ahuja, Neera, Artandi, Maja, Blish, Catherine A, Blomkalns, Andra L, Chang, Iris, Collins, William J, Desai, Manisha, Din, Hena Naz, Do, Evan, Fernandes, Andrea, Geng, Linda N, Rosenberg-Hasson, Yael, Mahoney, Megan Ruth, Glascock, Abigail L, Chan, Lienna Y, Fong, Sharon Y, Consortium, CLIAHUB, Biohub, Chan Zuckerberg, Phelps, Maira, Raeber, Olivia, Group, Stanford COVID-19 Biobank Study, Purington, Natasha, Röltgen, Katharina, Rogers, Angela J, Snow, Theo, Wang, Taia T, Solis, Daniel, Vaughan, Laura, Verghese, Michelle, Maecker, Holden, Wittman, Richard, Puri, Rajan, Kistler, Amy, Yang, Samuel, Boyd, Scott D, Pinsky, Benjamin A, Chinthrajah, Sharon, and Nadeau, Kari C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Lung, Clinical Research, Infectious Diseases, Good Health and Well Being, COVID-19, Humans, Immunoglobulin G, SARS-CoV-2, Post-Acute COVID-19 Syndrome, CLIAHUB Consortium, Chan Zuckerberg Biohub, Stanford COVID-19 Biobank Study Group, Immunoglobulins, Infectious disease, Biomedical and clinical sciences, Health sciences
Abstract

BACKGROUNDProlonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with biomarkers are points that remain elusive.METHODSAdult SARS-CoV-2 reverse transcription PCR-positive (RT-PCR-positive) patients were recruited at Stanford from March 2020 to February 2021. Study participants were seen for in-person visits at diagnosis and every 1-3 months for up to 1 year after diagnosis; they completed symptom surveys and underwent blood draws and nasal swab collections at each visit.RESULTSOur cohort (n = 617) ranged from asymptomatic to critical COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median time from diagnosis to sustained symptom resolution with no recurring symptoms for 1 month or longer was 214 days. Anti-nucleocapsid IgG level in the first week after positive RT-PCR test and history of lung disease were associated with time to sustained symptom resolution. COVID-19 disease severity, ethnicity, age, sex, and remdesivir use did not affect time to sustained symptom resolution.CONCLUSIONWe found that all disease severities had a similar risk of developing post-COVID-19 syndrome in an ethnically diverse population. Comorbid lung disease and lower levels of initial IgG response to SARS-CoV-2 nucleocapsid antigen were associated with longer symptom duration.TRIAL REGISTRATIONClinicalTrials.gov, NCT04373148.FUNDINGNIH UL1TR003142 CTSA grant, NIH U54CA260517 grant, NIEHS R21 ES03304901, Sean N Parker Center for Allergy and Asthma Research at Stanford University, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative, Sunshine Foundation, Crown Foundation, and Parker Foundation.

Published
2022

4. Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

Author

Chakraborty, Saborni, Gonzalez, Joseph C, Sievers, Benjamin L, Mallajosyula, Vamsee, Chakraborty, Srijoni, Dubey, Megha, Ashraf, Usama, Cheng, Bowie Yik-Ling, Kathale, Nimish, Tran, Kim Quyen Thi, Scallan, Courtney, Sinnott, Aanika, Cassidy, Arianna, Chen, Steven T, Gelbart, Terri, Gao, Fei, Golan, Yarden, Ji, Xuhuai, Kim-Schulze, Seunghee, Prahl, Mary, Gaw, Stephanie L, Gnjatic, Sacha, Marron, Thomas U, Merad, Miriam, Arunachalam, Prabhu S, Boyd, Scott D, Davis, Mark M, Holubar, Marisa, Khosla, Chaitan, Maecker, Holden T, Maldonado, Yvonne, Mellins, Elizabeth D, Nadeau, Kari C, Pulendran, Bali, Singh, Upinder, Subramanian, Aruna, Utz, Paul J, Sherwood, Robert, Zhang, Sheng, Jagannathan, Prasanna, Tan, Gene S, and Wang, Taia T

Subjects
Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Pneumonia & Influenza, Lung, Vaccine Related, Pneumonia, Prevention, Biotechnology, Immunization, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Respiratory, Good Health and Well Being, Antibodies, Neutralizing, Antibodies, Viral, Antibody Formation, COVID-19, COVID-19 Vaccines, Humans, Prospective Studies, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated immunoglobulin G (IgG) antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were associated with progression from mild to more severe COVID-19. To study the biology of afucosylated IgG immune complexes, we developed an in vivo model that revealed that human IgG-Fc-gamma receptor (FcγR) interactions could regulate inflammation in the lung. Afucosylated IgG immune complexes isolated from patients with COVID-19 induced inflammatory cytokine production and robust infiltration of the lung by immune cells. In contrast to the antibody structures that were associated with disease progression, antibodies that were elicited by messenger RNA SARS-CoV-2 vaccines were highly fucosylated and enriched in sialylation, both modifications that reduce the inflammatory potential of IgG. Vaccine-elicited IgG did not promote an inflammatory lung response. These results show that human IgG-FcγR interactions regulate inflammation in the lung and define distinct lung activities mediated by the IgG that are associated with protection against, or progression to, severe COVID-19.

Published
2022

5. Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses

Author

Sievers, Benjamin L, Chakraborty, Saborni, Xue, Yong, Gelbart, Terri, Gonzalez, Joseph C, Cassidy, Arianna G, Golan, Yarden, Prahl, Mary, Gaw, Stephanie L, Arunachalam, Prabhu S, Blish, Catherine A, Boyd, Scott D, Davis, Mark M, Jagannathan, Prasanna, Nadeau, Kari C, Pulendran, Bali, Singh, Upinder, Scheuermann, Richard H, Frieman, Matthew B, Vashee, Sanjay, Wang, Taia T, and Tan, Gene S

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Pneumonia, Emerging Infectious Diseases, Biodefense, Pneumonia & Influenza, Prevention, Biotechnology, Vaccine Related, Lung, Clinical Research, Infectious Diseases, Immunization, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Infection, Good Health and Well Being, Adult, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, COVID-19 Vaccines, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, mRNA Vaccines, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the current vaccines have largely been effective against past variants, the number of mutations found on the Omicron (B.1.1.529) spike protein appear to diminish the protection conferred by preexisting immunity. Using vesicular stomatitis virus (VSV) pseudoparticles expressing the spike protein of several SARS-CoV-2 variants, we evaluated the magnitude and breadth of the neutralizing antibody response over time in individuals after infection and in mRNA-vaccinated individuals. We observed that boosting increases the magnitude of the antibody response to wild-type (D614), Beta, Delta, and Omicron variants; however, the Omicron variant was the most resistant to neutralization. We further observed that vaccinated healthy adults had robust and broad antibody responses, whereas responses may have been reduced in vaccinated pregnant women, underscoring the importance of learning how to maximize mRNA vaccine responses in pregnant populations. Findings from this study show substantial heterogeneity in the magnitude and breadth of responses after infection and mRNA vaccination and may support the addition of more conserved viral antigens to existing SARS-CoV-2 vaccines.

Published
2022

6. Multiple early factors anticipate post-acute COVID-19 sequelae

Author

Su, Yapeng, Yuan, Dan, Chen, Daniel G, Ng, Rachel H, Wang, Kai, Choi, Jongchan, Li, Sarah, Hong, Sunga, Zhang, Rongyu, Xie, Jingyi, Kornilov, Sergey A, Scherler, Kelsey, Pavlovitch-Bedzyk, Ana Jimena, Dong, Shen, Lausted, Christopher, Lee, Inyoul, Fallen, Shannon, Dai, Chengzhen L, Baloni, Priyanka, Smith, Brett, Duvvuri, Venkata R, Anderson, Kristin G, Li, Jing, Yang, Fan, Duncombe, Caroline J, McCulloch, Denise J, Rostomily, Clifford, Troisch, Pamela, Zhou, Jing, Mackay, Sean, DeGottardi, Quinn, May, Damon H, Taniguchi, Ruth, Gittelman, Rachel M, Klinger, Mark, Snyder, Thomas M, Roper, Ryan, Wojciechowska, Gladys, Murray, Kim, Edmark, Rick, Evans, Simon, Jones, Lesley, Zhou, Yong, Rowen, Lee, Liu, Rachel, Chour, William, Algren, Heather A, Berrington, William R, Wallick, Julie A, Cochran, Rebecca A, Micikas, Mary E, Unit, the ISB-Swedish COVID-19 Biobanking, Wrin, Terri, Petropoulos, Christos J, Cole, Hunter R, Fischer, Trevan D, Wei, Wei, Hoon, Dave SB, Price, Nathan D, Subramanian, Naeha, Hill, Joshua A, Hadlock, Jennifer, Magis, Andrew T, Ribas, Antoni, Lanier, Lewis L, Boyd, Scott D, Bluestone, Jeffrey A, Chu, Helen, Hood, Leroy, Gottardo, Raphael, Greenberg, Philip D, Davis, Mark M, Goldman, Jason D, and Heath, James R

Subjects
Clinical Research, Prevention, Infectious Diseases, Good Health and Well Being, Adaptive Immunity, Adolescent, Adult, Aged, Aged, 80 and over, Autoantibodies, Biomarkers, Blood Proteins, CD8-Positive T-Lymphocytes, COVID-19, Convalescence, Disease Progression, Female, Humans, Immunity, Innate, Longitudinal Studies, Male, Middle Aged, Risk Factors, SARS-CoV-2, Transcriptome, Young Adult, Post-Acute COVID-19 Syndrome, ISB-Swedish COVID-19 Biobanking Unit, PASC, RNAemia, antibodies, auto-antibodies, computational biology, immune system, immunology, long COVID, metabolomics, multi-omics, proteomics, single cell, single-cell CITE-seq, single-cell RNA-seq, single-cell TCR-seq, single-cell secretome, symptoms, transcriptome, viremia, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8+ T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies.

Published
2022

7. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants

Author

Le, Brian L, Sper, Renan, Nielsen, Sandra CA, Pineda, Silvia, Nguyen, Quoc-Hung, Lee, Ji-Yeun, Boyd, Scott D, MacKenzie, Tippi C, and Sirota, Marina

Subjects
Pediatric, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Complementarity Determining Regions, Female, Humans, Immunoglobulin Heavy Chains, Infant, Newborn, Infant, Premature, Obstetric Labor, Premature, Pregnancy, Premature Birth, Receptors, Antigen, T-Cell, Immunology
Abstract

Preterm labor (PTL) is the leading cause of neonatal morbidity and mortality worldwide. Whereas many studies have investigated the maternal immune responses that cause PTL, fetal immune cell activation has recently been raised as an important contributor to the pathogenesis of PTL. In this study, we analyzed lymphocyte receptor repertoires in maternal and cord blood from 14 term and 10 preterm deliveries, hypothesizing that the high prevalence of infection in patients with PTL may result in specific changes in the T cell and B cell repertoires. We analyzed TCR β-chain (TCR-β) and IgH diversity, CDR3 lengths, clonal sharing, and preferential usage of variable and joining gene segments. Both TCR-β and IgH repertoires had shorter CDR3s compared with those in maternal blood. In cord blood samples, we found that CDR3 lengths correlated with gestational age, with shorter CDR3s in preterm neonates suggesting a less developed repertoire. Preterm cord blood displayed preferential usage of a number of genes. In preterm pregnancies, we observed significantly higher prevalence of convergent clones between mother/baby pairs than in term pregnancies. Together, our results suggest the repertoire of preterm infants displays a combination of immature features and convergence with maternal TCR-β clones compared with that of term infants. The higher clonal convergence in PTL could represent mother and fetus both responding to a shared stimulus like an infection. These data provide a detailed analysis of the maternal-fetal immune repertoire in term and preterm patients and contribute to a better understanding of neonate immune repertoire development and potential changes associated with PTL.

Published
2021

8. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

Author

Yang, Fan, Nielsen, Sandra CA, Hoh, Ramona A, Röltgen, Katharina, Wirz, Oliver Fabian, Haraguchi, Emily, Jean, Grace H, Lee, Ji-Yeun, Pham, Tho D, Jackson, Katherine JL, Roskin, Krishna M, Liu, Yi, Nguyen, Khoa, Ohgami, Robert S, Osborne, Eleanor M, Nadeau, Kari C, Niemann, Claus U, Parsonnet, Julie, and Boyd, Scott D

Subjects
Emerging Infectious Diseases, Biotechnology, Biodefense, Infectious Diseases, Vaccine Related, Pediatric, Lung, Prevention, Immunization, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, B-Lymphocytes, Child, Preschool, Coronavirus, Cross Reactions, Ebolavirus, Female, Fetal Blood, Genes, Immunoglobulin, Humans, Immunoglobulin Class Switching, Immunoglobulin D, Immunoglobulin Heavy Chains, Immunoglobulin M, Immunologic Memory, Infant, Lymph Nodes, Male, Middle Aged, Receptors, Antigen, B-Cell, SARS-CoV-2, Somatic Hypermutation, Immunoglobulin, Spleen, Young Adult, General Science & Technology
Abstract

Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.

Published
2021

9. Modeling human adaptive immune responses with tonsil organoids

Author

Wagar, Lisa E, Salahudeen, Ameen, Constantz, Christian M, Wendel, Ben S, Lyons, Michael M, Mallajosyula, Vamsee, Jatt, Lauren P, Adamska, Julia Z, Blum, Lisa K, Gupta, Neha, Jackson, Katherine JL, Yang, Fan, Röltgen, Katharina, Roskin, Krishna M, Blaine, Kelly M, Meister, Kara D, Ahmad, Iram N, Cortese, Mario, Dora, Emery G, Tucker, Sean N, Sperling, Anne I, Jain, Aarti, Davies, D Huw, Felgner, Philip L, Hammer, Gregory B, Kim, Peter S, Robinson, William H, Boyd, Scott D, Kuo, Calvin J, and Davis, Mark M

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Biotechnology, Pneumonia & Influenza, Vaccine Related, Prevention, Influenza, Emerging Infectious Diseases, Biodefense, Immunization, Underpinning research, 1.1 Normal biological development and functioning, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Inflammatory and immune system, Infection, Good Health and Well Being, Adjuvants, Immunologic, B-Lymphocytes, COVID-19 Vaccines, Germinal Center, Hemagglutinin Glycoproteins, Influenza Virus, Humans, In Vitro Techniques, Influenza Vaccines, Lymphoid Tissue, Measles-Mumps-Rubella Vaccine, Organoids, Palatine Tonsil, Rabies Vaccines, T-Lymphocytes, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymphoid organs, to develop a functional organotypic system that recapitulates key germinal center features in vitro, including the production of antigen-specific antibodies, somatic hypermutation and affinity maturation, plasmablast differentiation and class-switch recombination. We use this system to define the essential cellular components necessary to produce an influenza vaccine response. We also show that it can be used to evaluate humoral immune responses to two priming antigens, rabies vaccine and an adenovirus-based severe acute respiratory syndrome coronavirus 2 vaccine, and to assess the effects of different adjuvants. This system should prove useful for studying critical mechanisms underlying adaptive immunity in much greater depth than previously possible and to rapidly test vaccine candidates and adjuvants in an entirely human system.

Published
2021

11. Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children

Author

Martinez, Olivia M., Krams, Sheri M., Robien, Mark A., Lapasaran, Mary G., Arvedson, Matthew P., Reitsma, Andrea, Balachandran, Yarl, Harris-Arnold, Aleishia, Weinberg, Kenneth, Boyd, Scott D., Armstrong, Brian, Trickey, Amber, Twist, Clare J., Gratzinger, Dita, Tan, Brent, Brown, Merideth, Chin, Clifford, Desai, Dev M., Fishbein, Thomas M., Mazariegos, George V., Tekin, Akin, Venick, Robert S., Bernstein, Daniel, and Esquivel, Carlos O.

Published
2023
Full Text
View/download PDF

12. Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection

Author

Gao, Fei, Mallajoysula, Vamsee, Arunachalam, Prabhu S., van der Ploeg, Kattria, Manohar, Monali, Röltgen, Katharina, Yang, Fan, Wirz, Oliver, Hoh, Ramona, Haraguchi, Emily, Lee, Ji-Yeun, Willis, Richard, Ramachandiran, Vasanthi, Li, Jiefu, Kathuria, Karan Raj, Li, Chunfeng, Lee, Alexandra S., Shah, Mihir M., Sindher, Sayantani B., Gonzalez, Joseph, Altman, John D., Wang, Taia T., Boyd, Scott D., Pulendran, Bali, Jagannathan, Prasanna, Nadeau, Kari C., and Davis, Mark.M.

Published
2023
Full Text
View/download PDF

13. Epstein–Barr virus‐associated post‐transplant lymphoproliferative disorders in pediatric transplantation: A prospective multicenter study in the United States

Author

Tajima, Tetsuya, primary, Martinez, Olivia M., additional, Bernstein, Daniel, additional, Boyd, Scott D., additional, Gratzinger, Dita, additional, Lum, Grant, additional, Sasaki, Kazunari, additional, Tan, Brent, additional, Twist, Clare J., additional, Weinberg, Kenneth, additional, Armstrong, Brian, additional, Desai, Dev M., additional, Mazariegos, George V., additional, Chin, Clifford, additional, Fishbein, Thomas M., additional, Tekin, Akin, additional, Venick, Robert S., additional, Krams, Sheri M., additional, and Esquivel, Carlos O., additional

Published
2024
Full Text
View/download PDF

14. Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus

Author

Sarin, Kavita Y., primary, Zheng, Hong, additional, Chaichian, Yashaar, additional, Arunachalam, Prabhu S., additional, Swaminathan, Gayathri, additional, Eschholz, Alec, additional, Gao, Fei, additional, Wirz, Oliver F., additional, Lam, Brandon, additional, Yang, Emily, additional, Lee, Lori W., additional, Feng, Allan, additional, Lewis, Matthew A., additional, Lin, Janice, additional, Maecker, Holden T., additional, Boyd, Scott D., additional, Davis, Mark M., additional, Nadeau, Kari C., additional, Pulendran, Bali, additional, Khatri, Purvesh, additional, Utz, Paul J., additional, and Zaba, Lisa C., additional

Published
2024
Full Text
View/download PDF

15. CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy

Author

Kaushik, Abhinav, Dunham, Diane, Han, Xiaorui, Do, Evan, Andorf, Sandra, Gupta, Sheena, Fernandes, Andrea, Kost, Laurie Elizabeth, Sindher, Sayantani B., Yu, Wong, Tsai, Mindy, Tibshirani, Robert, Boyd, Scott D., Desai, Manisha, Maecker, Holden T., Galli, Stephen J., Chinthrajah, R. Sharon, DeKruyff, Rosemarie H., Manohar, Monali, and Nadeau, Kari C.

Published
2022
Full Text
View/download PDF

16. Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Author

Arunachalam, Prabhu S., Scott, Madeleine K. D., Hagan, Thomas, Li, Chunfeng, Feng, Yupeng, Wimmers, Florian, Grigoryan, Lilit, Trisal, Meera, Edara, Venkata Viswanadh, Lai, Lilin, Chang, Sarah Esther, Feng, Allan, Dhingra, Shaurya, Shah, Mihir, Lee, Alexandra S., Chinthrajah, Sharon, Sindher, Sayantani B., Mallajosyula, Vamsee, Gao, Fei, Sigal, Natalia, Kowli, Sangeeta, Gupta, Sheena, Pellegrini, Kathryn, Tharp, Gregory, Maysel-Auslender, Sofia, Hamilton, Sydney, Aoued, Hadj, Hrusovsky, Kevin, Roskey, Mark, Bosinger, Steven E., Maecker, Holden T., Boyd, Scott D., Davis, Mark M., Utz, Paul J., Suthar, Mehul S., Khatri, Purvesh, Nadeau, Kari C., and Pulendran, Bali

Published
2023
Full Text
View/download PDF

18. Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

Author

Feyaerts, Dorien, Hédou, Julien, Gillard, Joshua, Chen, Han, Tsai, Eileen S., Peterson, Laura S., Ando, Kazuo, Manohar, Monali, Do, Evan, Dhondalay, Gopal K.R., Fitzpatrick, Jessica, Artandi, Maja, Chang, Iris, Snow, Theo T., Chinthrajah, R. Sharon, Warren, Christopher M., Wittman, Richard, Meyerowitz, Justin G., Ganio, Edward A., Stelzer, Ina A., Han, Xiaoyuan, Verdonk, Franck, Gaudillière, Dyani K., Mukherjee, Nilanjan, Tsai, Amy S., Rumer, Kristen K., Jacobsen, Danielle R., Bjornson-Hooper, Zachary B., Jiang, Sizun, Saavedra, Sergio Fragoso, Valdés Ferrer, Sergio Iván, Kelly, J. Daniel, Furman, David, Aghaeepour, Nima, Angst, Martin S., Boyd, Scott D., Pinsky, Benjamin A., Nolan, Garry P., Nadeau, Kari C., Gaudillière, Brice, and McIlwain, David R.

Published
2022
Full Text
View/download PDF

19. Influenza virus infection history shapes antibody responses to influenza vaccination

Author

Auladell, Maria, Phuong, Hoang Vu Mai, Mai, Le Thi Quynh, Tseng, Yeu-Yang, Carolan, Louise, Wilks, Sam, Thai, Pham Quang, Price, David, Duong, Nguyen Thanh, Hang, Nguyen Le Khang, Thanh, Le Thi, Thuong, Nguyen Thi Hong, Huong, Tran Thi Kieu, Diep, Nguyen Thi Ngoc, Bich, Vu Thi Ngoc, Khvorov, Arseniy, Hensen, Luca, Duong, Tran Nhu, Kedzierska, Katherine, Anh, Dang Duc, Wertheim, Heiman, Boyd, Scott D., Good-Jacobson, Kim L., Smith, Derek, Barr, Ian, Sullivan, Sheena, van Doorn, H. Rogier, and Fox, Annette

Published
2022
Full Text
View/download PDF

20. Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

Author

Pillet, Stéphane, Arunachalam, Prabhu S., Andreani, Guadalupe, Golden, Nadia, Fontenot, Jane, Aye, Pyone Pyone, Röltgen, Katharina, Lehmicke, Gabrielle, Gobeil, Philipe, Dubé, Charlotte, Trépanier, Sonia, Charland, Nathalie, D’Aoust, Marc-André, Russell-Lodrigue, Kasi, Monjure, Christopher, Blair, Robert V., Boyd, Scott D., Bohm, Rudolf P., Rappaport, Jay, Villinger, François, Landry, Nathalie, Pulendran, Bali, and Ward, Brian J.

Published
2022
Full Text
View/download PDF

21. Efficient Identification of High-Titer Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Plasma Samples by Pooling Method

Author

Nguyen, Khoa D., Wirz, Oliver F., Roltgen, Katharina, Pandey, Suchitra, Tolentino, Lorna, Boyd, Scott D., and Pham, Tho D.

Subjects
Immune system -- Testing, Enzyme-linked immunosorbent assay -- Usage, Blood plasma -- Testing, Immunoglobulin G -- Testing, Health
Abstract

* Context.--The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has elicited a surge in demand for serologic testing to identify previously infected individuals. In particular, antibody testing is crucial in identifying COVID-19 convalescent plasma, which has been approved by the Food and Drug Administration under the Emergency Use Authorization for use as passive immunotherapy for hospitalized patients infected with COVID-19. Currently, high-titer COVID-19 convalescent plasma can be qualified by Ortho's Vitros COVID-19 IgG antibody test. Objective.--To explore the use of an efficient testing method to identify high-titer COVID-19 convalescent plasma for use in treating COVID-19-infected patients and track COVID-19 positivity over time. Design.--We evaluated an enzyme-linked immunosorbent assay (ELISA)-based method that detects antibodies specific to the SARS-CoV-2 receptor binding domain (RBD) with individual and pooled plasma samples and compared its performance against the Vitros COVID-19 IgG antibody test. Using the pooled RBD-ELISA (P-RE) method, we also screened more than 10 000 longitudinal healthy blood donor samples to assess seroprevalence. Results.--P-RE demonstrates 100% sensitivity in detecting Food and Drug Administration-defined high-titer samples when compared with the Vitros COVID-19 IgG antibody test. Overall sensitivity of P-RE when compared with the Vitros COVID-19 IgG antibody test and our individual sample RBD-ELISA (I-RE) were 83% and 56%, respectively. When screening 10 218 healthy blood donor samples by P-RE, we found the seroprevalence correlated with the local infection rates with a correlation coefficient of 0.21 (P < .001). Conclusions.--Pooling plasma samples can be used to efficiently screen large populations for individuals with high-titer anti-RBD antibodies, important for COVID-19 convalescent plasma identification. doi: 10.5858/arpa.2021-0215-SA, Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), the virus that causes COVID-19, was first detected in Wuhan, China in December 2019 and has quickly led to a global pandemic on [...]

Published
2021
Full Text
View/download PDF

22. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

Author

Ellebedy, Ali H., Nachbagauer, Raffael, Jackson, Katherine J. L., Dai, Ya-Nan, Han, Julianna, Alsoussi, Wafaa B., Davis, Carl W., Stadlbauer, Daniel, Rouphael, Nadine, Chromikova, Veronika, McCausland, Megan, Chang, Cathy Y., Cortese, Mario, Bower, Mary, Chennareddy, Chakravarthy, Schmitz, Aaron J., Zarnitsyna, Veronika I., Lai, Lilin, Rajabhathor, Arvind, Kazemian, Cheyann, Antia, Rustom, Mulligan, Mark J., Ward, Andrew B., Fremont, Daved H., Boyd, Scott D., Pulendran, Bali, Krammer, Florian, and Ahmed, Rafi

Published
2020

23. Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Author

Arunachalam, Prabhu S., Scott, Madeleine K. D., Hagan, Thomas, Li, Chunfeng, Feng, Yupeng, Wimmers, Florian, Grigoryan, Lilit, Trisal, Meera, Edara, Venkata Viswanadh, Lai, Lilin, Chang, Sarah Esther, Feng, Allan, Dhingra, Shaurya, Shah, Mihir, Lee, Alexandra S., Chinthrajah, Sharon, Sindher, Sayantani B., Mallajosyula, Vamsee, Gao, Fei, Sigal, Natalia, Kowli, Sangeeta, Gupta, Sheena, Pellegrini, Kathryn, Tharp, Gregory, Maysel-Auslender, Sofia, Hamilton, Sydney, Aoued, Hadj, Hrusovsky, Kevin, Roskey, Mark, Bosinger, Steven E., Maecker, Holden T., Boyd, Scott D., Davis, Mark M., Utz, Paul J., Suthar, Mehul S., Khatri, Purvesh, Nadeau, Kari C., and Pulendran, Bali

Published
2021
Full Text
View/download PDF

24. Gastrointestinal Eosinophil Responses in a Longitudinal, Randomized Trial of Peanut Oral Immunotherapy

Author

Wright, Benjamin L., Fernandez-Becker, Nielsen Q., Kambham, Neeraja, Purington, Natasha, Cao, Shu, Tupa, Dana, Zhang, Wenming, Sindher, Sayantani B., Rank, Matthew A., Kita, Hirohito, Katzka, David A., Shim, Kelly P., Bunning, Bryan J., Doyle, Alfred D., Jacobsen, Elizabeth A., Tsai, Mindy, Boyd, Scott D., Manohar, Monali, and Chinthrajah, R. Sharon

Published
2021
Full Text
View/download PDF

25. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Author

Arunachalam, Prabhu S., Walls, Alexandra C., Golden, Nadia, Atyeo, Caroline, Fischinger, Stephanie, Li, Chunfeng, Aye, Pyone, Navarro, Mary Jane, Lai, Lilin, Edara, Venkata Viswanadh, Röltgen, Katharina, Rogers, Kenneth, Shirreff, Lisa, Ferrell, Douglas E., Wrenn, Samuel, Pettie, Deleah, Kraft, John C., Miranda, Marcos C., Kepl, Elizabeth, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, White, Alexander G., Trisal, Meera, Hsieh, Ching-Lin, Russell-Lodrigue, Kasi, Monjure, Christopher, Dufour, Jason, Spencer, Skye, Doyle-Meyers, Lara, Bohm, Rudolph P., Maness, Nicholas J., Roy, Chad, Plante, Jessica A., Plante, Kenneth S., Zhu, Alex, Gorman, Matthew J., Shin, Sally, Shen, Xiaoying, Fontenot, Jane, Gupta, Shakti, O’Hagan, Derek T., Van Der Most, Robbert, Rappuoli, Rino, Coffman, Robert L., Novack, David, McLellan, Jason S., Subramaniam, Shankar, Montefiori, David, Boyd, Scott D., Flynn, JoAnne L., Alter, Galit, Villinger, Francois, Kleanthous, Harry, Rappaport, Jay, Suthar, Mehul S., King, Neil P., Veesler, David, and Pulendran, Bali

Published
2021
Full Text
View/download PDF

26. Large-Scale Testing of Asymptomatic Healthcare Personnel for Severe Acute Respiratory Syndrome Coronavirus 2

Author

Hogan, Catherine A., Gombar, Saurabh, Wang, Hannah, Roltgen, Katharina, Shi, Run-Zhang, Holubar, Marisa, Chang, Sang-ick, Lee, Grace M., Boyd, Scott D., Zehnder, James, and Pinsky, Benjamin A.

Subjects
Epidemics -- Control -- United States, Public health administration -- Methods, Carrier state (Communicable diseases) -- Testing, Medical personnel -- Health aspects -- Safety and security measures, Health
Abstract

Healthcare personnel (HCP) represent a unique group of concern for transmission of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), the causative agent of coronavirus disease (COVID-19), because of their increased [...]

Published
2021
Full Text
View/download PDF

28. Local immune response to food antigens drives meal-induced abdominal pain

Author

Aguilera-Lizarraga, Javier, Florens, Morgane V., Viola, Maria Francesca, Jain, Piyush, Decraecker, Lisse, Appeltans, Iris, Cuende-Estevez, Maria, Fabre, Naomi, Van Beek, Kim, Perna, Eluisa, Balemans, Dafne, Stakenborg, Nathalie, Theofanous, Stavroula, Bosmans, Goele, Mondelaers, Stéphanie U., Matteoli, Gianluca, Ibiza Martínez, Sales, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Talavera, Karel, Alpizar, Yeranddy A., Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Farre, Ricard, Redegeld, Frank A., Si, Jiyeon, Raes, Jeroen, Breynaert, Christine, Schrijvers, Rik, Bosteels, Cédric, Lambrecht, Bart N., Boyd, Scott D., Hoh, Ramona A., Cabooter, Deirdre, Nelis, Maxim, Augustijns, Patrick, Hendrix, Sven, Strid, Jessica, Bisschops, Raf, Reed, David E., Vanner, Stephen J., Denadai-Souza, Alexandre, Wouters, Mira M., and Boeckxstaens, Guy E.

Published
2021
Full Text
View/download PDF

29. Proinflammatory IgG Fc structures in patients with severe COVID-19

Author

Chakraborty, Saborni, Gonzalez, Joseph, Edwards, Karlie, Mallajosyula, Vamsee, Buzzanco, Anthony S., Sherwood, Robert, Buffone, Cindy, Kathale, Nimish, Providenza, Susan, Xie, Markus M., Andrews, Jason R., Blish, Catherine A., Singh, Upinder, Dugan, Haley, Wilson, Patrick C., Pham, Tho D., Boyd, Scott D., Nadeau, Kari C., Pinsky, Benjamin A., Zhang, Sheng, Memoli, Matthew J., Taubenberger, Jeffery K., Morales, Tasha, Schapiro, Jeffrey M., Tan, Gene S., Jagannathan, Prasanna, and Wang, Taia T.

Published
2021
Full Text
View/download PDF

31. Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR

Author

Mikelov, Artem, primary, Nefedev, George, additional, Tashkeev, Aleksandr, additional, Rodriguez, Oscar L., additional, Ortmans, Diego A., additional, Skatova, Valeriia, additional, Izraelson, Mark, additional, Davydov, Alexey, additional, Poslavsky, Stanislav, additional, Rahmouni, Souad, additional, Watson, Corey T., additional, Chudakov, Dmitriy, additional, Boyd, Scott D., additional, and Bolotin, Dmitry A., additional

Published
2023
Full Text
View/download PDF

32. 311.2: Risk factors for Epstein-Barr virus DNAemia in pediatric transplantation: A multicenter study in the United States

Author

Tajima, Tetsuya, primary, Bernstein, Daniel, additional, Boyd, Scott D, additional, Gratzinger, Dita, additional, Lum, Grant, additional, Sasaki, Kazunari, additional, Tan, Brent, additional, Weinberg, Kenneth, additional, Armstrong, Brian, additional, Brown, Meredith, additional, Chin, Clifford, additional, Desai, Dev, additional, Fishbein, Thomas M, additional, Mazariegos, George, additional, Robien, Mark A, additional, Tekin, Akin, additional, Twist, Clare J, additional, Venick, Robert S, additional, Krams, Sheri M, additional, Martinez, Olivia M, additional, and Esquivel, Carlos O, additional

Published
2023
Full Text
View/download PDF

39. Addendum: Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Author

Arunachalam, Prabhu S., primary, Scott, Madeleine K. D., additional, Hagan, Thomas, additional, Li, Chunfeng, additional, Feng, Yupeng, additional, Wimmers, Florian, additional, Grigoryan, Lilit, additional, Trisal, Meera, additional, Edara, Venkata Viswanadh, additional, Lai, Lilin, additional, Chang, Sarah Esther, additional, Feng, Allan, additional, Dhingra, Shaurya, additional, Shah, Mihir, additional, Lee, Alexandra S., additional, Chinthrajah, Sharon, additional, Sindher, Sayantani B., additional, Mallajosyula, Vamsee, additional, Gao, Fei, additional, Sigal, Natalia, additional, Kowli, Sangeeta, additional, Gupta, Sheena, additional, Pellegrini, Kathryn, additional, Tharp, Gregory, additional, Maysel-Auslender, Sofia, additional, Hamilton, Sydney, additional, Aoued, Hadj, additional, Hrusovsky, Kevin, additional, Roskey, Mark, additional, Bosinger, Steven E., additional, Maecker, Holden T., additional, Boyd, Scott D., additional, Davis, Mark M., additional, Utz, Paul J., additional, Suthar, Mehul S., additional, Khatri, Purvesh, additional, Nadeau, Kari C., additional, and Pulendran, Bali, additional

Published
2023
Full Text
View/download PDF

41. Advances and potential of omics studies for understanding the development of food allergy

Author

Sindher, Sayantani B., primary, Chin, Andrew R., additional, Aghaeepour, Nima, additional, Prince, Lawrence, additional, Maecker, Holden, additional, Shaw, Gary M., additional, Stevenson, David K., additional, Nadeau, Kari C., additional, Snyder, Michael, additional, Khatri, Purvesh, additional, Boyd, Scott D., additional, Winn, Virginia D., additional, Angst, Martin S., additional, and Chinthrajah, R. Sharon, additional

Published
2023
Full Text
View/download PDF

42. Robust T cell responses to Pfizer/BioNTech vaccine compared to infection and evidence of attenuated peripheral CD8+ T cell responses due to COVID-19

Author

Gao, Fei, primary, Mallajoysula, Vamsee, additional, Arunachalam, Prabhu S., additional, van der Ploeg, Kattria, additional, Manohar, Monali, additional, Röltgen, Katharina, additional, Yang, Fan, additional, Wirz, Oliver, additional, Hoh, Ramona, additional, Haraguchi, Emily, additional, Lee, Ji-Yeun, additional, Willis, Richard, additional, Ramachandiran, Vasanthi, additional, Li, Jiefu, additional, Kathuria, Karan Raj, additional, Li, Chunfeng, additional, Lee, Alexandra S., additional, Shah, Mihir M., additional, Sindher, Sayantani B., additional, Gonzalez, Joseph, additional, Altman, John D., additional, Wang, Taia T., additional, Boyd, Scott D., additional, Pulendran, Bali, additional, Jagannathan, Prasanna, additional, Nadeau, Kari C., additional, and Davis, Mark. M., additional

Published
2023
Full Text
View/download PDF

45. Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

Author

Goldman, Jason D., primary, Wang, Kai, additional, Röltgen, Katharina, additional, Nielsen, Sandra C. A., additional, Roach, Jared C., additional, Naccache, Samia N., additional, Yang, Fan, additional, Wirz, Oliver F., additional, Yost, Kathryn E., additional, Lee, Ji-Yeun, additional, Chun, Kelly, additional, Wrin, Terri, additional, Petropoulos, Christos J., additional, Lee, Inyoul, additional, Fallen, Shannon, additional, Manner, Paula M., additional, Wallick, Julie A., additional, Algren, Heather A., additional, Murray, Kim M., additional, Hadlock, Jennifer, additional, Chen, Daniel, additional, Dai, Chengzhen L., additional, Yuan, Dan, additional, Su, Yapeng, additional, Jeharajah, Joshua, additional, Berrington, William R., additional, Pappas, George P., additional, Nyatsatsang, Sonam T., additional, Greninger, Alexander L., additional, Satpathy, Ansuman T., additional, Pauk, John S., additional, Boyd, Scott D., additional, and Heath, James R., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results