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35 results on '"Bozovic Gracijela"'

2. Early-stage COVID-19 pandemic observations on pulmonary embolism using nationwide multi-institutional data harvesting

Author

Wismüller, Axel, DSouza, Adora M., Abidin, Anas Z., Ali Vosoughi, M., Gange, Christopher, Cortopassi, Isabel O., Bozovic, Gracijela, Bankier, Alexander A., Batra, Kiran, Chodakiewitz, Yosef, Xi, Yin, Whitlow, Christopher T., Ponnatapura, Janardhana, Wendt, Gary J., Weinberg, Eric P., Stockmaster, Larry, Shrier, David A., Shin, Min Chul, Modi, Roshan, Lo, Hao Steven, Kligerman, Seth, Hamid, Aws, Hahn, Lewis D., Garcia, Glenn M., Chung, Jonathan H., Altes, Talissa, Abbara, Suhny, and Bader, Anna S.

Published
2022
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4. A new era of high-resolution CT diagnostics of the lung: improved image quality, detailed morphology, and reduced radiation dose with high-resolution photon-counting CT of the lungs compared to high-resolution energy-integrated CT.

Author

Aurumskjöld, Marie-Louise, Sjunnesson, Lotta, Pistea, Adrian, Ásbjörnsson, Gylfi, Wellman, Fredrik, and Bozovic, Gracijela

Subjects
INTERSTITIAL lung diseases, COMPUTED tomography, BODY mass index, RADIATION doses, LUNGS
Abstract

Background: High-resolution computed tomography (HRCT) is dependent on detailed morphology in diagnostic assessment of interstitial lung diseases. Photon-counting CT (PCCT) enables improved resolution while reducing radiation. Purpose: To compare if the image quality, detailed morphology, and radiation dose in HRCT of the lung improves with PCCT compared to energy-integrated CT (EICT). Material and Methods: HRCT with PCCT in patients with body mass index (BMI) from normal to obese, previously examined with different EICT were included. They were evaluated in a five-step scale for image quality according to Quality Criteria for CT (Diagnostic Requirement of the ImPACT group-European standardization). In addition, ground-glass opacities, bronchiectasis, emphysema, nodules, and subpleural detailed morphology (≤1 cm from the pleural border) were evaluated by three independent thoracic and/or pediatric radiologists. Visual grading characteristics (VGC) were used for comparison of image quality and detailed morphology and Fleiss kappa for intra-observer variability. Dose-length product (DLP) and CT dose index-volume (CTDIvol) were collected to calculate effective radiation dose. Results: HRCT with PCCT in 52 women and 48 men (mean age=67.2 ± 13.6 years; age range=27–87 years; BMI=26.9 kg/m2; range=18.6–45 kg/m2) previously examined with EICT (mean age=65.3 ± 13.6 years; age range=27–85 years; BMI=27 kg/m2; range=18.9–45 kg/m2) were included. There were significant differences in image quality for all entities in favor of PCCT. The radiation dose was reduced with PCCT by 47% in all, particularly pronounced in obese with 48.5%. Conclusion: Image quality, detailed morphology, and radiation dose, particularly in obese patients, were significantly improved in HRCT with PCCT compared to conventional EICT. The new technique enables visualization of subpleural structures. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Late Breaking Abstract - Artificial intelligence-based dec­­­ision support for HRCT stratification in fibrotic lung disease; an international study of 116 observers from 37 countries.

Author

Calandriello, Lucio, primary, Mackintosh, John, additional, Felder, Federico, additional, Agrawal, Aditya, additional, Alamoudi, Omer, additional, Alberti, Laura, additional, Aquaro, Giuseppe, additional, Arenas-Jiménez, Juan, additional, Au-Yong, Iain, additional, Avdeev, Sergey, additional, Balbi, Maurizio, additional, Baldi, Bruno, additional, Ban, Andrea Yu-Lin, additional, Belaconi, Ionela-Nicoleta, additional, Bendstrup, Elisabeth, additional, Bennett, David, additional, Blum, Hans-Christian, additional, Boscolo Bariga, Nicola, additional, Bozovic, Gracijela, additional, Broqi, Marsel, additional, Bruzzi, John, additional, Buendia-Roldan, Ivette, additional, Calaras, Diana, additional, Campainha, Sérgio, additional, Carbone, Roberto G., additional, Carvalho, André, additional, Cereser, Lorenzo, additional, Chai, Gin Tsen, additional, Chaudhary, Sachin, additional, Chaudhuri, Nazia, additional, Chui Wan Cheong, Patrick Alain, additional, Cooper, Wendy, additional, Cutaia, Giuseppe, additional, D'Abronzo, Rosa, additional, De Kruif, Martijn D., additional, Delgado-García, Diemen, additional, Dhooria, Sahajal, additional, Diaz-Castanon, Jesus J, additional, Eiger, Glenn, additional, Ellis, Samantha, additional, Estrada-Y-Martin, Rosa, additional, and Fang, Yingying, additional

Published
2023
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14. Interobserver agreement for the ATS/ERS/JRS/ALAT criteria for a UIP pattern on CT

Author

Walsh, Simon L F, Calandriello, Lucio, Sverzellati, Nicola, Wells, Athol U, Hansell, David M, Jacob, Joseph, Devaraj, Anand, Gavelli, Giampaola, Nath, Hrudaya, Tashjian, Joseph, Tack, Denis, Monostori, Zsuzsanna, Johkoh, Takeshi, Davies, Anne, Zompatori, Maurizio, Polverosi, Roberta, Sassani, Ennio Vincenzo, R Ferretti, Gilbert, Zafer Karaman, Can, Sergiacomi, Gianluigi, Franquet, Tomas, Garg, Kavita, Mannion, Richard, Campos, Paula, Karl, Robert, Burrowes, Paul, Quagliarini, Franco, Norlen, Louise, Murchison, John T, Khalil, Antoine, Nayak, Sundeep M, Nchimi, Alain, Karabulut, Nevzat, Larici, Anna Rita, Matthews, Suzanne, Castañer, Eva, Arenas-Jimenez, Juan, Drosten, Ralph, Egashira, Ryoko, Lee, Hyun-Ju, Rossi, Santiago, Al-Raddadi, Mosleh, Oikonomou, Anastasia, Parkar, Anagha P, Brillet, Pierre Yves, de Paula, Wagner Diniz, Medart, Laurent, Poschenrieder, Florian, Pozek, Igor, Senbanjo, Taiwo, Marten-Engelke, Katharina, Euathrongchit, Juntima, Delaplain, Cal, Cortese, Giancarlo, Soardi, Gian Alberto, Grgic, Aleksandar, Kanne, Jeffrey, Muller, Michelle, Bruzzi, John, Jankowski, Adrien, Bozovic, Gracijela, Goncalves, Andrea, Roos, Justus, Vargas, Daniel, Elias, Mark, Bradford-Kennedy, Djenaba, Seaman, Danielle, Memauri, Brett, Chaudhary, Humera, Wong, Foong, Alegria, Julia, Guo, H Henry, Prosch, Helmut, Cantin, Luce, Serra, Goffredo, Baratella, Elisa, Silecchia, Rosalba, Icksan, Aziza, Wallis, Adam, Damani, Sidhdharth, Renapurkar, Rahul, Hare, Samanjit, Ciello, Annemilia del, Jung, Jennifer, Silva, Mario, Sonavane, Sushilkumar, Thomas, Sue, Beattie, Anna, Kislinger, Benedikt, Ca, Leo, Shroff, Girish, Gietema, Hester, Weerakkody, Yuranga, Hobbs, Stephen, Izumi, Shinyu, Kishaba, Tomoo, Shiraki, Akira, Waseda, Yuko, Castoldi, Maria Chiara, Herpels, Vincent, Pais, Antonio, Matus, Roger, Lubin, Enrico, Wilson, Ben, Mueller, Mathias, Alzubaidi, Shadha Ahmed, Ortiz, Alain, Sequeiros, lara, Bariga, Nicola Boscolo, Wills, Mark, Mak, Sze Mun, Aquaro, Giuseppe, Midia, Esin Cakmakci, Schembri, Nicola, Sheehan, Joseph A M, Farrugia, Alexia, Tomich, Jennifer, and Garcia-Hierro, J M Fernandez

Published
2016
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15. Pulmonary functional imaging (PFI): A historical review and perspective.

Author

Bozovic, Gracijela, Schaefer-Prokop, Cornelia M, and Bankier, Alexander A

Subjects
*PULMONARY artery, *COMPUTED tomography, *GAS flow, *MAGNETIC resonance imaging, *ELECTRON beams
Abstract

PFI Pulmonary Functional Imaging (PFI) refers to visualization and measurement of ventilation, perfusion, gas flow and exchange as well as biomechanics. In this review, we will highlight the historical development of PFI, describing recent advances and listing the various techniques for PFI offered per modality. Challenges PFI is facing and requirements for PFI from a clinical point of view will be pointed out. Hereby the review is meant as an introduction to PFI. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A round atelectasis developing a squamous lung cancer

Author

Bozovic, Gracijela

Subjects
Oncology, Clinical Cases, Chest imaging, Thorax, Conventional radiography, CT, Cancer
Abstract

Clinical History: An elderly gentleman of 79 years suffering from diabetes and COPD with asbestos exposure and smoking history, and previous malignant melanoma from which he had been declared healthy. He complains about weight loss and declining wellbeing. He had palpable cervical lymph nodes and pain in one rib dorsolateral on the right side., 79 years, male

Published
2020
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26. Inflammation and chronic colonization of Haemophilus influenzae in sputum in COPD patients related to the degree of emphysema and bronchiectasis in high-resolution computed tomography

Author

Tufvesson,Ellen, Markstad,Hanna, Bozovic,Gracijela, Ekberg,Marie, Bjermer,Leif, Tufvesson,Ellen, Markstad,Hanna, Bozovic,Gracijela, Ekberg,Marie, and Bjermer,Leif

Abstract

Ellen Tufvesson,1 Hanna Markstad,2 Gracijela Bozovic,2 Marie Ekberg,1 Leif Bjermer1 1Respiratory Medicine and Allergology, 2Radiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden Abstract: The presence of bacteria in the lower airways in COPD results in inflammation, further airway structural damage, and might lead to repeated exacerbations. We have previously shown that chronic colonization of Haemophilus influenzae during stable disease is related to increased inflammation, and we now aimed to relate previous findings of bacterial colonization and inflammation to the degree of radiological findings of bronchiectasis and emphysema. Thirty-nine patients with COPD were included in their stable state, and a high-resolution computed tomography of the lung was performed. They were followed-up monthly for up to a maximum of 6 months or until exacerbation, and they answered questionnaires, performed spirometry, and induced sputum at every visit. Thirty-five patients had emphysema with an emphysema degree of median 20% (interquartile range 10–50), and five patients had bronchiectasis, of which only four could expectorate sputum. The degree of emphysema correlated with several inflammatory mediators in sputum, such as interleukin-8 concentration, myeloperoxidase activity, and Leukotriene B4 concentration. Ten patients were chronically colonized with H. influenzae (ie, had a positive culture for H. influenzae at all visits). The four sputum patients with bronchiectasis were chronically colonized with H. influenzae and showed higher degree of H. influenzae growth compared to patients without bronchiectasis. During exacerbation, there was no longer any correlation between emphysema degree and inflammation, but patients with bronchiectasis showed higher sputum purulence score than patients without bronchiectasis. Emphysema and bronchiectasis in COPD patients show different clinical features. The pre

Published
2017

31. Pulmonary blood volume indexed to lung volume is reduced in newly diagnosed systemic sclerosis compared to normals - a prospective clinical cardiovascular magnetic resonance study addressing pulmonary vascular changes

Author

Kanski, Mikael, Arheden, Håkan, Wuttge, Dirk, Bozovic, Gracijela, Hesselstrand, Roger, Ugander, Martin, Kanski, Mikael, Arheden, Håkan, Wuttge, Dirk, Bozovic, Gracijela, Hesselstrand, Roger, and Ugander, Martin

Abstract

Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-seven SSc patients (9 men, 57 +/- 13 years) and 10 healthy controls (3 men, 54 +/- 9 years) underwent CMR to determine the pulmonary blood volume (PBV) and the PBV variation (PBVV) throughout the cardiac cycle. Patients underwent Doppler echocardiography, high-resolution computed tomography (HRCT), and pulmonary function testing by spirometry. Comparisons were performed using the unpaired t-test and linear regression analysis was performed with Pearson's correlation coefficient (r). Results: Compared to healthy controls, the PBV indexed to lung volume (PBVI) was lower in patients (16 +/- 4 vs 20 +/- 5%, p < 0.05). There was no difference in PBV (466 +/- 87 vs 471 +/- 122 mL, p = 0.91) or PBVV/stroke volume (45 +/- 10 vs 40 +/- 6%, p = 0.09). There were no significant correlations between PBVI and pulmonary artery pressure estimated by Doppler (p = 0.08) the lung's diffusion capacity for carbon monoxide (DLCO) (p = 0.09), vital capacity (p = 0.45), or pulmonary fibrosis by HRCT (p = 0.74). Conclusions: This study is the first to measure the PBV in humans using CMR. Compared to healthy controls, newly diagnosed SSc patients have a reduced amount of blood in the pulmonary vasculature (PBVI) but unchanged pulmonary vascular distensibility (PBVV/stroke volume). PBVI is unrelated to DLCO, pulmonary artery pressure, vital capacity, and the presence of pulmonary fibrosis. PBVI may be a novel parameter reflecting vascular lung involvement in early-stage SSc, and these findings may be consistent with pathophysiological changes of the pulmonary vasculature.

Published
2013

35. A seventeenth-century Mycobacterium tuberculosisgenome supports a Neolithic emergence of the Mycobacterium tuberculosiscomplex

Author

Sabin, Susanna, Herbig, Alexander, Vågene, Åshild J., Ahlström, Torbjörn, Bozovic, Gracijela, Arcini, Caroline, Kühnert, Denise, and Bos, Kirsten I.

Abstract

Background: Although tuberculosis accounts for the highest mortality from a bacterial infection on a global scale, questions persist regarding its origin. One hypothesis based on modern Mycobacterium tuberculosiscomplex (MTBC) genomes suggests their most recent common ancestor followed human migrations out of Africa approximately 70,000 years before present. However, studies using ancient genomes as calibration points have yielded much younger dates of less than 6000 years. Here, we aim to address this discrepancy through the analysis of the highest-coverage and highest-quality ancient MTBC genome available to date, reconstructed from a calcified lung nodule of Bishop Peder Winstrup of Lund (b. 1605–d. 1679). Results: A metagenomic approach for taxonomic classification of whole DNA content permitted the identification of abundant DNA belonging to the human host and the MTBC, with few non-TB bacterial taxa comprising the background. Genomic enrichment enabled the reconstruction of a 141-fold coverage M. tuberculosisgenome. In utilizing this high-quality, high-coverage seventeenth-century genome as a calibration point for dating the MTBC, we employed multiple Bayesian tree models, including birth-death models, which allowed us to model pathogen population dynamics and data sampling strategies more realistically than those based on the coalescent. Conclusions: The results of our metagenomic analysis demonstrate the unique preservation environment calcified nodules provide for DNA. Importantly, we estimate a most recent common ancestor date for the MTBC of between 2190 and 4501 before present and for Lineage 4 of between 929 and 2084 before present using multiple models, confirming a Neolithic emergence for the MTBC.

Published
2020
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