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145 results on '"Bozzarelli, S."'

2. Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy. Primary analysis of the GARIBALDI survey

Author

Reni, Michele, Macchini, Marina, Orsi, Giulia, Peretti, Umberto, Valente, Mariamaddalena, Giommoni, Elisa, Antonuzzo, Lorenzo, Di Costanzo, Francesco, Bergamo, Francesca, Zagonel, Vittorina, Lonardi, Sara, Buggin, Federica, Milella, Michele, Palmerio, Silvia, Cavanna, Luigi, Di Nunzio, Camilla, Di Marco, Maria Cristina, Grassi, Elisa, Spada, Massimiliano, Messina, Marco, Cordio, Stefano, Avola, Francesco, Aprile, Giuseppe, Pagano, Salvatore, Simionato, Francesca, Cardellino, Giovanni Gerardo, Majer, Federica, Maiello, Evaristo, Latiano, Tiziana Pia, Chiarazzo, Cinzia, Artioli, Fabrizio, Razzini, Giorgia, Pasqualini, Antonella, Ghidini, Michele, Binda, Elisa, Lazzarelli, Silvia, Bozzarelli, Silvia, Sala, Simona, Luppi, Gabriele, Pettorelli, Elisa, Spallanzani, Andrea, Vicario, Giovanni, Salmaso, Flavia, Basso, Marco, Silvestris, Nicola, Del Curatolo, Sabina, Zustovich, Fable, Bongiovanni, Francesca, Longobardi, Ciro, Sandi, Ilenia, Fontanella, Caterina, Montelatici, Silvia, Giordano, Monica, Luchena, Giovanna, Gilardoni, Micol, Tamburini, Emiliano, Rudnas, Britt, Venturini, Barbara, Merelli, Barbara, Negrini, Giorgia, Vici, Elio Maria, Marabese, Alessandra, Garetto, Cristina, Curcio, Paola, Cinieri, Saverio, Cinefra, Margherita, Ferrara, Pasqualinda, Cantore, Maurizio, Morselli, Patrizia, Fumi, Guglielmo, Isidori, Agnese, Ciccarese, Giovanni, Paolo Frassineti, Giovanni Luca, Pagan, Flavia, Vaccaro, Vanja, Spoto, Chiara, Ferrara, Marianna, Garufi, Carlo, Caporale, Marta, Vasile, Enrico, Salani, Francesca, Barone, Elisa, Berardi, Rossana, Onofri, Azzurra, Ballatore, Zelmira, Lucarelli, Alessandra, Barucca, Alessandra, Pancotti, Amedeo, Scipioni, Teresa, Bencardino, Katia, Marrapese, Giovanna, Idotta, Laura, Petrelli, Fausto, Lonati, Veronica, Ceribelli, Anna, Giuli, Angelo, Zannori, Cristina, Bassanelli, Maria, Mambrini, Andrea, Ginocchi, Laura, Orlandi, Massimo, Celio, Luigi, Niger, Monica, Biamonte, Lavinia, Tamberi, Stefano, Piancastelli, Alessandra, Papiani, Giorgio, Valli, Irene, Allione, Paolo, Boe, Maria Giovanna, Scartozzi, Mario, Lai, Eleonora, Pireddu, Annagrazia, Ziranu, Pina, Demurtas, Laura, Puzzoni, Marco, Mariani, Stefano, Pretta, Andrea, Liscia, Nicole, Savastano, Clementina, Malaspina, Valentina, Tonini, Giuseppe, Grassani, Teresa, Barco, Barbara, Pierosandro, Tagliaferri, Ciliberto, Domenico, Ierardi, Antonella, Calandruccio, Natale Daniele, Minotti, Vincenzo, Matocci, Roberta, Torri, Valter, Porcu, Luca, Rulli, Erica, De Simone, Irene, Carlucci, Luciano, Rulli, Eliana, Poli, Davide, Tonto, Paola, Scellato, Francesca, Pinto, Carmine, Reni, M., Giommoni, E., Bergamo, F., Milella, M., Cavanna, L., Di Marco, M.C., Spada, M., Cordio, S., Aprile, G., Cardellino, G.G., Maiello, E., Bernardini, I., Ghidini, M., Bozzarelli, S., Macchini, M., Orsi, G., De Simone, I., Rulli, Er., Porcu, L., Torri, V., and Pinto, C.

Published
2023
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3. Chemotherapy toxicity and activity in patients with pancreatic ductal adenocarcinoma and germline BRCA1-2 pathogenic variants (gBRCA1-2pv): a multicenter survey

Author

Orsi, G., Di Marco, M., Cavaliere, A., Niger, M., Bozzarelli, S., Giordano, G., Noventa, S., Rapposelli, I.G., Garajova, I., Tortora, G., Rodriquenz, M.G., Bittoni, A., Penzo, E., De Lorenzo, S., Peretti, U., Paratore, C., Bernardini, I., Mosconi, S., Spallanzani, A., Macchini, M., Tamburini, E., Bencardino, K., Giommoni, E., Scartozzi, M., Forti, L., Valente, M.M., Militello, A.M., Cascinu, S., Milella, M., and Reni, M.

Published
2021
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5. BD-IPMN surveillance: a real-life experience from an Italian level III center

Author

Terrin, M., additional, Poletti, V., additional, Mercurio, M., additional, Minini, F., additional, Spertino, M., additional, Cataldo, D. P., additional, Bonifacio, C., additional, Spadaccini, M., additional, Colombo, M., additional, Spaggiari, P., additional, Sollai, M., additional, Andreozzi, M., additional, Rossi, R. E., additional, Bozzarelli, S., additional, Fugazza, A., additional, Repici, A., additional, Zerbi, A., additional, and Carrara, S., additional

Published
2024
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6. Estimating 12-week death probability in patients with refractory metastatic colorectal cancer: the Colon Life nomogram

Author

Pietrantonio, F., Miceli, R., Rimassa, L., Lonardi, S., Aprile, G., Mennitto, A., Marmorino, F., Bozzarelli, S., Antonuzzo, L., Tamburini, E., Morano, F., Rossini, D., Battaglin, F., Baretti, M., Berenato, R., Formica, V., Mosconi, S., Petrelli, F., Ghidini, M., Loupakis, F., Spada, D., Cinieri, S., Beretta, G., Falcone, A., de Braud, F., and Cremolini, C.

Published
2017
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7. Prognostic value of Body Mass Index in stage II/III colon cancer: post-hoc analysis from the TOSCA trial

Author

Basile, D., primary, Rosati, G., additional, Bergamo, F., additional, Garattini, S.K., additional, Banzi, M., additional, Zampino, M., additional, Bozzarelli, S., additional, Marchetti, P., additional, Galli, F., additional, Longarini, R., additional, Zaniboni, A., additional, Ferrari, D., additional, De Placido, S., additional, Frassineti, L., additional, Nicolini, M., additional, Cinieri, S., additional, Priscindiaro, M., additional, Ziranu, P., additional, Caccialanza, R., additional, Pastorino, A., additional, Mosconi, S., additional, and Aprile, G., additional

Published
2023
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8. Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial

Author

Rosati, G, Lonardi, S, Galli, F, Di Bartolomeo, M, Ronzoni, M, Zampino, M, Banzi, M, Zaniboni, A, Pasini, F, Bozzarelli, S, Garattini, S, Ferrari, D, Montesarchio, V, Mambrini, A, Ciuffreda, L, Pusceddu, V, Carlomagno, C, Bidoli, P, Amoroso, D, Bochicchio, A, Frassineti, L, Corsi, D, Bilancia, D, Pastorino, A, De Stefano, A, Labianca, R, Iaffaioli, R, Nasti, G, Daniele, B, Zagonel, V, Pella, N, Aprile, G, Marchetti, R, Romiti, A, Foa, P, Mosconi, S, Sobrero, A, Cazzaniga, M, Beretta, G, Cortesi, E, Barni, S, Petrelli, F, Allione, P, D'Arco, A, Valmadre, G, Piazza, E, Veltri, E, Ramus, G, Giustini, L, Tumulo, S, Cascinu, S, Granetto, C, Testore, F, Giordano, M, Moroni, M, Di Seri, M, Nuzzo, A, Angelelli, L, Gori, S, Farina, G, Aglietta, M, Franchi, R, Comande, M, Giordani, P, Tonini, G, Bucci, E, Ballestrero, A, Benasso, M, Graiff, C, Bravi, S, Caffo, O, Silva, R, Frontini, L, Rota, S, Cozzi, L, Cantore, M, Maiello, E, Cinieri, S, Silvestris, N, Romito, S, Gebbia, V, Santoro, A, Artioli, F, Mattioli, R, Contu, A, Di Costanzo, F, Leonardi, F, Cavanna, L, Passalacqua, R, Sozzi, P, D'Amico, M, Amadori, D, Turci, D, Ravaioli, A, Pasquini, E, Gambi, A, Faedi, M, Cruciani, G, Bajetta, E, Gianni, L, Ionta, M, Massidda, B, Scartozzi, M, Ciarlo, A, Di Leo, A, Frustaci, S, Rangoni, G, Arizzoia, A, Pavesi, L, Verusio, C, Pinotti, G, Iop, A, De Placido, S, Adamo, V, Ficorella, C, Natale, D, Greco, E, Rulli, E, Poli, D, Porcu, L, Torri, V, Rosati G., Lonardi S., Galli F., Di Bartolomeo M., Ronzoni M., Zampino M. G., Banzi M., Zaniboni A., Pasini F., Bozzarelli S., Garattini S. K., Ferrari D., Montesarchio V., Mambrini A., Ciuffreda L., Pusceddu V., Carlomagno C., Bidoli P., Amoroso D., Bochicchio A. M., Frassineti L., Corsi D., Bilancia D., Pastorino A., De Stefano A., Labianca R., Iaffaioli R. V., Nasti G., Daniele B., Zagonel V., Pella N., Aprile G., Marchetti R. P., Romiti A., Foa P., Mosconi S., Sobrero A., Cazzaniga M., Beretta G. D., Cortesi E., Barni S., Petrelli F., Allione P., D'Arco A. M., Valmadre G., Piazza E., Veltri E., Ramus G. V., Giustini L., Tumulo S., Cascinu S., Granetto C., Testore F., Giordano M., Moroni M., Di Seri M., Nuzzo A., Angelelli L., Gori S., Farina G., Aglietta M., Franchi R., Comande M., Giordani P., Tonini G., Bucci E., Ballestrero A., Benasso M., Graiff C., Bravi S., Caffo O., Silva R. R., Frontini L., Rota S., Cozzi L., Cantore M., Maiello E., Cinieri S., Silvestris N., Romito S., Gebbia V., Santoro A., Artioli F., Mattioli R., Contu A., Di Costanzo F., Leonardi F., Cavanna L., Passalacqua R., Sozzi P., D'Amico M., Amadori D., Turci D., Ravaioli A., Pasquini E., Gambi A., Faedi M., Cruciani G., Bajetta E., Gianni L., Ionta M. T., Massidda B., Scartozzi M., Ciarlo A., Di Leo A., Frustaci S., Rangoni G., Arizzoia A., Pavesi L., Verusio C., Pinotti G., Iop A., De Placido S., Adamo V., Ficorella C., Natale D., Greco E., Rulli E., Poli D., Porcu L., Torri V., Rosati, G, Lonardi, S, Galli, F, Di Bartolomeo, M, Ronzoni, M, Zampino, M, Banzi, M, Zaniboni, A, Pasini, F, Bozzarelli, S, Garattini, S, Ferrari, D, Montesarchio, V, Mambrini, A, Ciuffreda, L, Pusceddu, V, Carlomagno, C, Bidoli, P, Amoroso, D, Bochicchio, A, Frassineti, L, Corsi, D, Bilancia, D, Pastorino, A, De Stefano, A, Labianca, R, Iaffaioli, R, Nasti, G, Daniele, B, Zagonel, V, Pella, N, Aprile, G, Marchetti, R, Romiti, A, Foa, P, Mosconi, S, Sobrero, A, Cazzaniga, M, Beretta, G, Cortesi, E, Barni, S, Petrelli, F, Allione, P, D'Arco, A, Valmadre, G, Piazza, E, Veltri, E, Ramus, G, Giustini, L, Tumulo, S, Cascinu, S, Granetto, C, Testore, F, Giordano, M, Moroni, M, Di Seri, M, Nuzzo, A, Angelelli, L, Gori, S, Farina, G, Aglietta, M, Franchi, R, Comande, M, Giordani, P, Tonini, G, Bucci, E, Ballestrero, A, Benasso, M, Graiff, C, Bravi, S, Caffo, O, Silva, R, Frontini, L, Rota, S, Cozzi, L, Cantore, M, Maiello, E, Cinieri, S, Silvestris, N, Romito, S, Gebbia, V, Santoro, A, Artioli, F, Mattioli, R, Contu, A, Di Costanzo, F, Leonardi, F, Cavanna, L, Passalacqua, R, Sozzi, P, D'Amico, M, Amadori, D, Turci, D, Ravaioli, A, Pasquini, E, Gambi, A, Faedi, M, Cruciani, G, Bajetta, E, Gianni, L, Ionta, M, Massidda, B, Scartozzi, M, Ciarlo, A, Di Leo, A, Frustaci, S, Rangoni, G, Arizzoia, A, Pavesi, L, Verusio, C, Pinotti, G, Iop, A, De Placido, S, Adamo, V, Ficorella, C, Natale, D, Greco, E, Rulli, E, Poli, D, Porcu, L, Torri, V, Rosati G., Lonardi S., Galli F., Di Bartolomeo M., Ronzoni M., Zampino M. G., Banzi M., Zaniboni A., Pasini F., Bozzarelli S., Garattini S. K., Ferrari D., Montesarchio V., Mambrini A., Ciuffreda L., Pusceddu V., Carlomagno C., Bidoli P., Amoroso D., Bochicchio A. M., Frassineti L., Corsi D., Bilancia D., Pastorino A., De Stefano A., Labianca R., Iaffaioli R. V., Nasti G., Daniele B., Zagonel V., Pella N., Aprile G., Marchetti R. P., Romiti A., Foa P., Mosconi S., Sobrero A., Cazzaniga M., Beretta G. D., Cortesi E., Barni S., Petrelli F., Allione P., D'Arco A. M., Valmadre G., Piazza E., Veltri E., Ramus G. V., Giustini L., Tumulo S., Cascinu S., Granetto C., Testore F., Giordano M., Moroni M., Di Seri M., Nuzzo A., Angelelli L., Gori S., Farina G., Aglietta M., Franchi R., Comande M., Giordani P., Tonini G., Bucci E., Ballestrero A., Benasso M., Graiff C., Bravi S., Caffo O., Silva R. R., Frontini L., Rota S., Cozzi L., Cantore M., Maiello E., Cinieri S., Silvestris N., Romito S., Gebbia V., Santoro A., Artioli F., Mattioli R., Contu A., Di Costanzo F., Leonardi F., Cavanna L., Passalacqua R., Sozzi P., D'Amico M., Amadori D., Turci D., Ravaioli A., Pasquini E., Gambi A., Faedi M., Cruciani G., Bajetta E., Gianni L., Ionta M. T., Massidda B., Scartozzi M., Ciarlo A., Di Leo A., Frustaci S., Rangoni G., Arizzoia A., Pavesi L., Verusio C., Pinotti G., Iop A., De Placido S., Adamo V., Ficorella C., Natale D., Greco E., Rulli E., Poli D., Porcu L., and Torri V.

Abstract

Background: Previous studies on oxaliplatin and fluoropyrimidines as adjuvant therapy in older patients with stage III colon cancer (CC) produced conflicting results. Patients and methods: We assessed the impact of age on time to tumour recurrence (TTR), disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) in 2360 patients with stage III CC (1667 aged <70 years and 693 ≥ 70 years) randomised to receive 3 or 6 months of FOLFOX or CAPOX within the frame of the phase III, TOSCA study. Results: Older patients compared with younger ones presented more frequently an Eastern Cooperative Oncology Group performance status equal to 1 (10.5% vs 3.3%, p < 0.001), a greater number of right-sided tumours (40.9% vs 26.6%, p < 0.001), and were at higher clinical risk (37.2% vs 33.2%, p = 0.062). The treatments were almost identical in the two cohorts (p = 0.965). We found a greater proportion of dose reductions (46.7% vs 41.4%, p = 0.018), treatment interruptions (26.1% vs 19.3%, p < 0.001) and a higher proportion of recurrences (24.2% vs 20.3%, p = 0.033) in the older patients. The multivariable analysis of the TTR did not indicate a statistically significant effect of age (hazard ratio [HR]: 1.19; 95% confidence interval [CI]: 0.98–1.44; p = 0.082). The HR comparing older with younger patients was 1.34 (95% CI: 1.12–1.59; p = 0.001) for DFS, 1.58 (95% CI: 1.26–1.99; p < 0.001) for OS, and 1.28 (95% CI: 0.96–1.70; p = 0.089) for CSS. Conclusions: Worse prognostic factors and reduced treatment compliance have a negative impact on the efficacy of oxaliplatin-based adjuvant therapy in older patients.

Published
2021

9. 1307P Real-world impact of olaparib use in advanced pancreatic cancer (PC) patients (pts) harboring germline BRCA1/2 (gBRCA) mutations

Author

Milella, M., primary, Orsi, G., additional, Palloni, A., additional, Salvatore, L., additional, Procaccio, L., additional, Noventa, S., additional, Bozzarelli, S., additional, Garajova, I., additional, Vasile, E., additional, Giordano, G., additional, Macchini, M., additional, Cavaliere, A., additional, Gaule, M., additional, Lonardi, S., additional, Di Marco, M.C., additional, Tortora, G., additional, Sperduti, I., additional, and Reni, M., additional

Published
2022
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11. 1150P Search for biomarkers to personalize treatment with streptozotocin plus 5-fluorouracil or everolimus in patients with advanced pancreatic neuroendocrine tumors: The randomized phase III SEQTOR trial (GETNE-1206)

Author

Salazar Soler, R., Scarpa, A., Lawlor, R.T., Sadanandam, A., Tafuto, S., Krogh, M., Teule, A., Garcia-Carbonero, R., Klumpen, H.J., Cremer, B., Sevilla, I., Eriksson, B.K., Mitkina Tabaksblat, E., Metges, J-P., Reed, N.S., Schrader, J., Bozzarelli, S., Venerito, M., Navarro, V., and Capdevila Castillon, J.

Published
2024
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12. 1142O Multivariable analysis of streptozotocin plus 5-fluorouracil and everolimus sequences in advanced pancreatic neuroendocrine tumor patients: The SEQTOR trial (GETNE-1206)

Author

Capdevila Castillon, J., Tafuto, S., Krogh, M., Teule, A., Garcia-Carbonero, R., Klumpen, H.J., Cremer, B., Sevilla, I., Eriksson, B.K., Mitkina Tabaksblat, E., Metges, J-P., Reed, N.S., Schrader, J., Bozzarelli, S., Knigge, U., Jimenez-Fonseca, P., Benavent Viñuales, M., Venerito, M., Navarro, V., and Salazar Soler, R.

Published
2024
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13. SECONDARY TUMORS OF THE PANCREAS: A MULTICENTER ANALYSIS OF CLINICOPATHOLOGICAL AND ENDOSONOGRAPHIC FEATURES

Author

Spadaccini, M., additional, Crinò, S.F., additional, Fantin, A., additional, Rahal, D., additional, Manfrin, E., additional, Gavazzi, F., additional, Bozzarelli, S., additional, Conti Bellocchi, M.C., additional, Maselli, R., additional, Anderloni, A., additional, Fugazza, A., additional, Frulloni, L., additional, Repici, A., additional, and Carrara, S., additional

Published
2022
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15. 1479P Exploring second-line therapy outcome in pancreatic ductal adenocarcinoma (PDAC) patients with germlineBRCA1-2 pathogenic variants (gBRCA1-2pv)

Author

Orsi, G., primary, Milella, M., additional, Nappo, F., additional, Di Marco, M., additional, Niger, M., additional, Bozzarelli, S., additional, Rodriquenz, M.G., additional, Noventa, S., additional, Giordano, G., additional, Rapposelli, I.G., additional, Bernardini, I., additional, Vasile, E., additional, Macchini, M., additional, Peretti, U., additional, Valente, M.M., additional, Paratore, C., additional, Spallanzani, A., additional, Scartozzi, M., additional, Cascinu, S., additional, and Reni, M., additional

Published
2021
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17. 1666P Non-metastatic cohort of the Italian Association for Medical Oncology (AIOM) guideline application in real-world: Multi-Institutional based survey of adjuvant and first-line pancreatic ductal adenocarcinoma treatment in Italy (GARIBALDI)

Author

Pinto, C., Milella, M., Bergamo, F., Di Marco, M.C., Cardellino, G.G., Cavanna, L., Giommoni, E., Zustovich, F., Bonomi, M., Bozzarelli, S., Vicario, G., Parlagreco, E., Frassineti, G.L., Macchini, M., Orsi, G., Santoni, A., Caldirola, L., De Simone, I., and Reni, M.

Published
2023
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20. 1838P Do irinotecan (IRI) dose reductions driven by UGT1A1*28 genotyping prevent IRI-related severe neutropenia? A real-world study

Author

Personeni, N., primary, Mineri, R., additional, D'Alessio, A., additional, Cammarota, A., additional, Michelini, A., additional, Bozzarelli, S., additional, Smiroldo, V., additional, Pressiani, T., additional, Giordano, L., additional, Sandri, M.T., additional, Santoro, A., additional, and Rimassa, L., additional

Published
2020
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21. 399O Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in elderly patients: A subgroup analysis from TOSCA trial

Author

Rosati, G., primary, Galli, F., additional, Lonardi, S., additional, Dotti, K.F., additional, Ronzoni, M., additional, Zampino, M.G., additional, Banzi, M., additional, Pusceddu, V., additional, Pasini, F., additional, Bozzarelli, S., additional, Pella, N., additional, Codecà, C., additional, Montesarchio, V., additional, Mambrini, A., additional, De Stefano, A., additional, Ciuffreda, L., additional, Rebuzzi, S.E., additional, Bilancia, D., additional, and Labianca, R., additional

Published
2020
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22. COMPARISON OF DIAGNOSTIC GAINS BY NEXT-GENERATION PROFILING, CONVENTIONAL CYTOLOGY AND HISTOLOGY IN PATIENTS WITH LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA FOLLOWING EUS-GUIDED BIOPSY

Author

Carrara, S, additional, Laghi, L, additional, Giulia, S, additional, Di Leo, M, additional, Lamonaca, L, additional, Peano, C, additional, Rahal, D, additional, Bozzarelli, S, additional, Anderloni, A, additional, Fugazza, A, additional, Auriemma, F, additional, Duga, S, additional, and Repici, A, additional

Published
2020
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24. Clinical impact of mucinous and poorly differentiated tumours on the outcome of patients with stage II colon cancer: A TOSCA subgroup analysis

Author

Rosati, G., primary, Galli, F., additional, Cantore, M., additional, Lonardi, S., additional, Banzi, M., additional, Zampino, M.G., additional, Mattioli, R., additional, Pella, N., additional, Ronzoni, M., additional, Bartolomeo, M Di, additional, Tamberi, S., additional, Marchetti, P., additional, Bozzarelli, S., additional, Corsi, D.C., additional, Bochicchio, A.M., additional, Artioli, F., additional, Labianca, R., additional, Bilancia, D., additional, and Bregni, G., additional

Published
2019
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26. Erratum to: Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy (The Oncologist, (2017), 22, 12, (1463-1469), 10.1634/theoncologist.2017-0158)

Author

Fanotto, V., Uccello, M., Pecora, I., Rimassa, L., Leone, F., Rosati, G., Santini, D., Giampieri, R., Di Donato, S., Tomasello, G., Silvestris, N., Pietrantonio, F., Battaglin, F., Avallone, A., Scartozzi, M., Lutrino, E. S., Melisi, D., Antonuzzo, L., Pellegrino, A., Ferrari, L., Bordonaro, R., Vivaldi, C., Gerratana, L., Bozzarelli, S., Filippi, R., Bilancia, D., Russano, M., and Aprile, G.

Published
2018

27. A Phase II Randomized Dose Escalation Trial of Sorafenib in Patients With Advanced Hepatocellular Carcinoma

Author

Rimassa, L, Pressiani, T, Boni, C, Carnaghi, C, Rota Caremoli, E, Fagiuoli, S, Foa, P, Salvagni, S, Cortesi, E, Chiara Tronconi, M, Personeni, N, Bozzarelli, S, Chiara Banzi, M, Fanello, S, Romano Lutman, F, Giordano, L, Santoro, A, Rimassa L, Pressiani T, Boni C, Carnaghi C, Rota Caremoli E, Fagiuoli S, Foa P, Salvagni S, Cortesi E, Chiara Tronconi M, Personeni N, Bozzarelli S, Chiara Banzi M, Fanello S, Romano Lutman F, Giordano L, Santoro A., Rimassa, L, Pressiani, T, Boni, C, Carnaghi, C, Rota Caremoli, E, Fagiuoli, S, Foa, P, Salvagni, S, Cortesi, E, Chiara Tronconi, M, Personeni, N, Bozzarelli, S, Chiara Banzi, M, Fanello, S, Romano Lutman, F, Giordano, L, Santoro, A, Rimassa L, Pressiani T, Boni C, Carnaghi C, Rota Caremoli E, Fagiuoli S, Foa P, Salvagni S, Cortesi E, Chiara Tronconi M, Personeni N, Bozzarelli S, Chiara Banzi M, Fanello S, Romano Lutman F, Giordano L, and Santoro A.

Abstract

Background. Sorafenib has proven survival benefits in patients with advanced hepatocellular carcinoma (HCC). The viability of continuing sorafenib at a higher dosage in patients who experienced radiologic disease progression was investigated. Methods. Patients who experienced disease progression while on sorafenib 400 mg twice daily were randomized to sorafenib 600mgtwice daily (n49) or best supportive care (n52). The primary end point was progression-free survival (PFS). Time to progression, overall survival,andsafetywerealso evaluated. Results. The study did not meet its primary end point. The difference in PFS between the sorafenib arm (3.91 months) and the best supportive care arm (2.69 months) did not reach statistical significance (p = 0.086). Adverse events were mainly grade 1-2 and similar across both groups. In the sorafenib arm, the most frequent events were diarrhea (80%), weight loss (75%), fatigue (67%), hand-foot-skin reaction (49%), abdominal pain (37%), and stomatitis (26%). Conclusions. Escalated-dose sorafenib in patients with advanced HCC who progressed while on sorafenib, failed to provide any clinical benefit. Second-line treatment still remains an open issue to be explored in appropriate clinical trials

Published
2013

31. Safety and efficacy profile of ramucirumab alone or combined with paclitaxel in metastatic gastric cancer (MGC): A real-life overview of compassionate-use named patients (pts) (RAMoss study)

Author

Di Bartolomeo, M., primary, Niger, M., additional, Laterza, M.M., additional, Vivaldi, C., additional, Giommoni, E., additional, Zaniboni, A., additional, Bozzarelli, S., additional, Tomasello, G., additional, Sava, T., additional, Spada, M., additional, Bittoni, A., additional, Galdy, S., additional, Spallanzani, A., additional, Bassan, F., additional, Scagnoli, S., additional, Morano, F., additional, Berenato, R., additional, Caporale, M., additional, Filippo, P., additional, and De Vita, F., additional

Published
2016
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33. Ramucirumab as second line therapy in metastatic gastric cancer (MGC): results of the Italian compassionate-use named patients. The RAMoss study

Author

De Vita, F., primary, Niger, M., additional, Vivaldi, C., additional, Giommoni, E., additional, Zaniboni, A., additional, Bozzarelli, S., additional, Tomasello, G., additional, Sava, T., additional, Spada, M., additional, Menatti, E., additional, Proserpio, I., additional, Galdy, S., additional, Bittoni, A., additional, Bencardino, K., additional, Squadroni, M., additional, Latiano, T.P., additional, Spallanzani, A., additional, Tirino, G., additional, Petrillo, A., additional, and Di Bartolomeo, M., additional

Published
2016
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36. Characteristics and outcomes of advanced gastric cancer patients treated with at least three lines of chemotherapy: analysis on 300 Italian real-world cases

Author

Aprile, G., primary, Fanotto, V., additional, Vivaldi, C., additional, Fontanella, C., additional, Bordonaro, R., additional, Leone, F., additional, Rimassa, L., additional, Rosati, G., additional, Pasquini, G., additional, Tomasello, G., additional, Ferrari, L., additional, Santini, D., additional, Giampieri, R., additional, Pietrantonio, F., additional, Cordio, S., additional, Filippi, R., additional, Bozzarelli, S., additional, Caparello, C., additional, and Fornaro, L., additional

Published
2016
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37. Baseline characteristics and survival outcomes of advanced gastric cancer patients treated with two or more lines of chemotherapy: results from a large Italian cohort

Author

Ferrari, L., primary, Fontanella, C., additional, Uccello, M., additional, Pasquini, G., additional, Bozzarelli, S., additional, Filippi, R., additional, Imperatori, M., additional, Ferrara, D., additional, Tomasello, G., additional, Brunetti, O., additional, Pietrantonio, F., additional, Bellu, L., additional, Lutrino, E.S., additional, Melisi, D., additional, Antonuzzo, L., additional, Musettini, G., additional, Cordio, S., additional, Vivaldi, C., additional, Rimassa, L., additional, and Aprile, G., additional

Published
2015
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38. ONC-2014-001: An open-label phase II study of regorafenib in patients with metastatic solid tumors who have progressed after standard therapy - RESOUND

Author

Bozzarelli, S., primary, Rimassa, L., additional, Giordano, L., additional, Garassino, I., additional, Marrari, A., additional, Tronconi, M.C., additional, De Sanctis, R.M., additional, Cavina, R., additional, Baretti, M., additional, Personeni, N., additional, Pressiani, T., additional, and Santoro, A., additional

Published
2015
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39. Impact of age, ECOG PS and type of treatment on progression-free survival and overall survival in second-line therapy for advanced gastric cancer: analysis on 709 cases

Author

Fanotto, V., primary, Fontanella, C., additional, Uccello, M., additional, Pasquini, G., additional, Bozzarelli, S., additional, Leone, F., additional, Russano, M., additional, Rosati, G., additional, Tomasello, G., additional, Silvestris, N., additional, Pietrantonio, F., additional, Paladina, I., additional, Lutrino, E.S., additional, Melisi, D., additional, Antonuzzo, L., additional, Caparello, C., additional, Cordio, S., additional, Rotella, V., additional, Rimassa, L., additional, and Aprile, G., additional

Published
2015
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40. 2357 Prognostic factors in 709 advanced gastric cancer patients exposed to second-line therapy

Author

Fontanella, C., primary, Fanotto, V., additional, Uccello, M., additional, Vasile, E., additional, Bozzarelli, S., additional, Filippi, R., additional, Santini, D., additional, Rosati, G., additional, Tomasello, G., additional, Silvestris, N., additional, Pietrantonio, F., additional, Bergamo, F., additional, Cinieri, S., additional, Melisi, D., additional, Antonuzzo, L., additional, Fornaro, L., additional, Cordio, S., additional, Pasquini, G., additional, Rimassa, L., additional, and Aprile, G., additional

Published
2015
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41. O-008 Phase II study of tivantinib (ARQ 197) in combination with Cetuximab in EGFR Inhibitor-resistant, MET-High, KRAS Wild-Type (KRASwt) Metastatic Colorectal Cancer (mCRC)

Author

Rimassa, L., primary, Bozzarelli, S., additional, Cordio, S., additional, Toppo, L., additional, Lonardi, S., additional, Zaniboni, A., additional, Bordonaro, R., additional, Liguigli, W., additional, Zagonel, V., additional, Tronconi, M.C., additional, Di Tommaso, L., additional, Giordano, L., additional, and Santoro, A., additional

Published
2015
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43. 636P - Safety and efficacy profile of ramucirumab alone or combined with paclitaxel in metastatic gastric cancer (MGC): A real-life overview of compassionate-use named patients (pts) (RAMoss study)

Author

Di Bartolomeo, M., Niger, M., Laterza, M.M., Vivaldi, C., Giommoni, E., Zaniboni, A., Bozzarelli, S., Tomasello, G., Sava, T., Spada, M., Bittoni, A., Galdy, S., Spallanzani, A., Bassan, F., Scagnoli, S., Morano, F., Berenato, R., Caporale, M., Filippo, P., and De Vita, F.

Published
2016
Full Text
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50. L07 - Baseline characteristics and survival outcomes of advanced gastric cancer patients treated with two or more lines of chemotherapy: results from a large Italian cohort

Author

Ferrari, L., Fontanella, C., Uccello, M., Pasquini, G., Bozzarelli, S., Filippi, R., Imperatori, M., Ferrara, D., Tomasello, G., Brunetti, O., Pietrantonio, F., Bellu, L., Lutrino, E.S., Melisi, D., Antonuzzo, L., Musettini, G., Cordio, S., Vivaldi, C., Rimassa, L., and Aprile, G.

Published
2015
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