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2. Holmium-166 radioembolisation dosimetry in HCC

Author

Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, IJzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., and Smits, Maarten L. J.

Published
2025
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6. Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC: the RALLY protocol

Author

Andel, Daan, Lam, Marnix G. E. H., de Bruijne, Joep, Smits, Maarten L. J., Braat, Arthur J. A. T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J. S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N. M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, and Borel Rinkes, Inne H. M.

Published
2023
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9. Imaging in rhabdomyosarcoma: a patient journey

Author

de Vries, Isabelle S. A., van Ewijk, Roelof, Adriaansen, Laura M. E., Bohte, Anneloes E., Braat, Arthur J. A. T., Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S., Hol, Marinka L. F., ter Horst, Simone A. J., de Keizer, Bart, Knops, Rutger R. G., Meister, Michael T., Schoot, Reineke A., Smeele, Ludi E., van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H. M., and van Rijn, Rick R.

Published
2023
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20. Radioembolization

Author

van Roekel, Caren, Braat, Arthur J. A. T., Smits, Maarten L. J., Bruijnen, Rutger C. G., de Keizer, Bart, Lam, Marnix G. E. H., Ahmadzadehfar, Hojjat, editor, Biersack, Hans-Jürgen, editor, Freeman, Leonard M., editor, and Zuckier, Lionel S., editor

Published
2020
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21. Correction to: Imaging in rhabdomyosarcoma: a patient journey

Author

de Vries, Isabelle S. A., van Ewijk, Roelof, Adriaansen, Laura M. E., Bohte, Anneloes E., Braat, Arthur J. A. T., Fajardo, Raquel Dávila, Hiemcke‑Jiwa, Laura S., Hol, Marinka L. F., ter Horst, Simone A. J., de Keizer, Bart, Knops, Rutger R. G., Meister, Michael T., Schoot, Reineke A., Smeele, Ludi E., van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H. M., and van Rijn, Rick R.

Published
2023
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23. Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study

Author

Braat, Arthur J A T, Bruijnen, Rutger C G, van Rooij, Rob, Braat, Manon N G J A, Wessels, Frank J, van Leeuwaarde, Rachel S, van Treijen, Mark J C, de Herder, Wouter W, Hofland, Johannes, Tesselaar, Margot E T, de Jong, Hugo W A M, and Lam, Marnix G E H

Published
2020
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26. Holmium-166 radioembolisation dosimetry in HCC

Author

Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, Ijzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., Smits, Maarten L. J., Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, Ijzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., and Smits, Maarten L. J.

Abstract

PurposeTo evaluate dosimetry, dose-response and dose-toxicity relationships for holmium-166 (166Ho) radioembolisation in patients with hepatocellular carcinoma (HCC).MethodsThirty-one patients with hepatocellular carcinoma were included in the HEPAR Primary study (NCT03379844, registered on December 20th, 2017) and underwent 166Ho-microspheres radioembolisation. Linear mixed models assessed the association between tumour absorbed doses and response based on mRECIST both on tumour and patient level. Preliminary tumour absorbed dose thresholds were estimated based on predictive value. Linear regression models assessed the association between non-tumour absorbed dose and Common Terminology Criteria for Adverse Events version 4.03.ResultsMedian tumour absorbed dose (tumour level) was 95.5 Gy (range 44-332 Gy). Median non-tumour absorbed dose based on whole liver volume was 19 Gy (range 3 - 48 Gy) and based on target liver volume was 30 Gy (range 13 - 54 Gy). There was a significant association between non-tumour absorbed dose and toxicity. Tumours with partial response/complete response (PR/CR, responders) received a 41% higher absorbed dose than tumours with progressive disease/stable disease (PD/SD, non-responders) (95%CI: 2%-93%, p = 0.04). A predictive value of 90% for tumour response was observed at a tumour absorbed dose threshold of 155 Gy, 100% predictive value was achieved at 184.5 Gy.ConclusionThis study confirms a positive relationship between tumour absorbed dose and response and between non-tumour absorbed dose and toxicity. Dose thresholds found in this study can serve as a basis for personalized dosimetry in HCC patients treated with 166Ho-microspheres.

Published
2024

27. Lung Mean Dose Prediction in Transarterial Radioembolization (TARE): Superiority of [ 166Ho]-Scout Over [ 99mTc]MAA in a Prospective Cohort Study

Author

Researchgr. Nucleaire Geneeskunde, MS Radiologie, Cancer, Fysica Radiologie, Other research (not in main researchprogram), MS Radiotherapie, Brain, Wagemans, Martijn E H M, Braat, Arthur J A T, van Rooij, Rob, Smits, Maarten L J, Bruijnen, Rutger C G, Prince, Jip F, Bol, Guus M, de Jong, Hugo W A M, Lam, Marnix G E H, Researchgr. Nucleaire Geneeskunde, MS Radiologie, Cancer, Fysica Radiologie, Other research (not in main researchprogram), MS Radiotherapie, Brain, Wagemans, Martijn E H M, Braat, Arthur J A T, van Rooij, Rob, Smits, Maarten L J, Bruijnen, Rutger C G, Prince, Jip F, Bol, Guus M, de Jong, Hugo W A M, and Lam, Marnix G E H

Published
2024

28. Comparison of 3 Different Therapeutic Particles in Radioembolization of Locally Advanced Intrahepatic Cholangiocarcinoma

Author

Researchgr. Nucleaire Geneeskunde, Cancer, Fysica Radiologie, Brain, MS Radiologie, Wagemans, Martijn E H M, Kunnen, Britt, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, Braat, Arthur J A T, Researchgr. Nucleaire Geneeskunde, Cancer, Fysica Radiologie, Brain, MS Radiologie, Wagemans, Martijn E H M, Kunnen, Britt, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, and Braat, Arthur J A T

Published
2024

35. The Additional Value of Somatostatin Receptor Positron Emission Computed Tomography ([68Ga]Ga-DOTATOC PET/CT) Compared with Magnetic Resonance Imaging of the Head and Neck Region in Paraganglioma Patients: A Pilot Study

Author

de Bresser, Carolijn J. M., primary, Petri, Bart-Jeroen, additional, Braat, Arthur J. A. T., additional, de Keizer, Bart, additional, van Treijen, Mark J. C., additional, Dankbaar, Jan Willem, additional, Pameijer, Frank A., additional, Kok, Marius G. J., additional, de Ridder, Mischa, additional, van Nesselrooij, Bernadette P. M., additional, de Bree, Remco, additional, de Borst, Gert J., additional, and Rijken, Johannes A., additional

Published
2024
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36. Head and Neck Paraganglioma (HNPGL) Registry: A study protocol for prospective data collection in patients with Head and Neck Paragangliomas.

Author

de Bresser, Carolijn J. M., van Nesselrooij, Bernadette P. M., van Treijen, Mark J. C., Braat, Arthur J. A. T., de Ridder, Mischa, Stokroos, Robert J., de Bree, Remco, de Borst, Gert J., Rijken, Johannes A., and Petri, Bart-Jeroen

Subjects
PATIENT reported outcome measures, PARAGANGLIOMA, RESEARCH protocols, ACADEMIC medical centers
Abstract

Introduction: There is a lack of comprehensive and uniform data on head and neck paragangliomas (HNPGLs), and research is challenging due to its rarity and the involvement of multiple medical specialties. To improve current research data collection, we initiated the Head and Neck Paraganglioma Registry (HNPGL Registry). The aim of the HNPGL Registry is to a) collect extensive data on all HNPGL patients through a predefined protocol, b) give insight in the long term outcomes using patient reported outcome measures (PROMs), c) create uniformity in the diagnostic and clinical management of these conditions, and thereby d) help provide content for future (randomized) research. Methods and analysis: The HNPGL Registry is designed as a prospective longitudinal observational registry for data collection on HNPGL patients and carriers of (likely) pathogenic variants causative of HNPGLs. All patients, regardless of the received treatment modality, can be included in the registry after informed consent is obtained. All relevant data regarding the initial presentation, diagnostics, treatment, and follow-up will be collected prospectively in an electronic case report form. In addition a survey containing the EuroQol 5D-5L (EQ-5D-5L), European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), Modified Fatigue Impact Scale (MFIS), Short QUestionnaire to Assess Health-enhancing physical activity (SQUASH), Cancer Worry Scale (CWS) and Hospital Anxiety and Depression Scale (HADS) will be sent periodically. The registry protocol was approved by the Medical Ethical Review Board of the University Medical Center Utrecht. Conclusion: The HNPGL Registry data will be used to further establish the optimal management for HNPGL patients and lay the foundation for guideline recommendations and the outline of future research. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Prophylactic Medication during Radioembolization in Metastatic Liver Disease: Is It Really Necessary? A Retrospective Cohort Study and Systematic Review of the Literature

Author

Braat, Manon N. G. J. A., primary, Ebbers, Sander C., additional, Alsultan, Ahmed A., additional, Neek, Atal O., additional, Bruijnen, Rutger C. G., additional, Smits, Maarten L. J., additional, de Bruijne, Joep, additional, Lam, Marnix G. E. H., additional, and Braat, Arthur J. A. T., additional

Published
2023
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40. Results from a Phase I study of 4-L-[131I]iodo-phenylalanine ([ 131 I]IPA) in combination with external radiation therapy in patients with recurrent glioblastoma (IPAX-1)

Author

Pichler, Joseph, primary, Traub-Weidinger, Tatjana, additional, Spiegl, Kurt, additional, Imamovic, Larisa, additional, Braat, Arthur J. A. T., additional, Snijders, Tom J., additional, Verhoeff, Joost J. C., additional, Flamen, Patrick, additional, Tachmanova, Libuse, additional, Hayward, Colin, additional, and Kluge, Andreas, additional

Published
2023
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42. Lung Mean Dose Prediction in Transarterial Radioembolization (TARE): Superiority of [166Ho]-Scout Over [99mTc]MAA in a Prospective Cohort Study.

Author

Wagemans, Martijn E. H. M., Braat, Arthur J. A. T., van Rooij, Rob, Smits, Maarten L. J., Bruijnen, Rutger C. G., Prince, Jip F., Bol, Guus M., de Jong, Hugo W. A. M., and Lam, Marnix G. E. H.

Subjects
RADIOEMBOLIZATION, LONGITUDINAL method, RADIATION pneumonitis, LUNGS, COHORT analysis
Abstract

Purpose: Radiation pneumonitis is a serious complication of radioembolization. In holmium-166 ([166Ho]) radioembolization, the lung mean dose (LMD) can be estimated (eLMD) using a scout dose with either technetium-99 m-macroaggregated albumin ([99mTc]MAA) or [166Ho]-microspheres. The accuracy of eLMD based on [99mTc]MAA (eLMDMAA) was compared to eLMD based on [166Ho]-scout dose (eLMDHo-scout) in two prospective clinical studies. Materials and Methods: Patients were included if they received both scout doses ([99mTc]MAA and [166Ho]-scout), had a posttreatment [166Ho]-SPECT/CT (gold standard) and were scanned on the same hybrid SPECT/CT system. The correlation between eLMDMAA/eLMDHo-scout and LMDHo-treatment was assessed by Spearman's rank correlation coefficient (r). Wilcoxon signed rank test was used to analyze paired data. Results: Thirty-seven patients with unresectable liver metastases were included. During follow-up, none developed symptoms of radiation pneumonitis. Median eLMDMAA (1.53 Gy, range 0.09–21.33 Gy) was significantly higher than median LMDHo-treatment (0.00 Gy, range 0.00–1.20 Gy; p < 0.01). Median eLMDHo-scout (median 0.00 Gy, range 0.00–1.21 Gy) was not significantly different compared to LMDHo-treatment (p > 0.05). In all cases, eLMDMAA was higher than LMDHo-treatment (p < 0.01). While a significant correlation was found between eLMDHo-scout and LMDHo-treatment (r = 0.43, p < 0.01), there was no correlation between eLMDMAA and LMDHo-treatment (r = 0.02, p = 0.90). Conclusion: [166Ho]-scout dose is superior in predicting LMD over [99mTc]MAA, in [166Ho]-radioembolization. Consequently, [166Ho]-scout may limit unnecessary patient exclusions and avoid unnecessary therapeutic activity reductions in patients eligible for radioembolization. Trail registration: NCT01031784, registered December 2009. NCT01612325, registered June 2012. [ABSTRACT FROM AUTHOR]

Published
2024
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43. The Additional Value of Somatostatin Receptor Positron Emission Computed Tomography ([ 68 Ga]Ga-DOTATOC PET/CT) Compared with Magnetic Resonance Imaging of the Head and Neck Region in Paraganglioma Patients: A Pilot Study.

Author

de Bresser, Carolijn J. M., Petri, Bart-Jeroen, Braat, Arthur J. A. T., de Keizer, Bart, van Treijen, Mark J. C., Dankbaar, Jan Willem, Pameijer, Frank A., Kok, Marius G. J., de Ridder, Mischa, van Nesselrooij, Bernadette P. M., de Bree, Remco, de Borst, Gert J., and Rijken, Johannes A.

Subjects
HEAD & neck cancer diagnosis, DIAGNOSTIC imaging, PARAGANGLIOMA, HEAD & neck cancer, PILOT projects, POSITRON emission tomography computed tomography, MAGNETIC resonance imaging, DESCRIPTIVE statistics, SOMATOSTATIN, HEALTH outcome assessment, COMPARATIVE studies, CELL receptors
Abstract

Simple Summary: All patients suspected of having head and neck paragangliomas (HNPGLs) undergo magnetic resonance imaging (MRI) or computed tomography (CT) of the head and neck area as the standard imaging according to the Dutch guidelines. However, a relatively new imaging modality, [68Ga]Ga-DOTATOC PET/CT, has shown promising results in the detection of HNPGLs. In this pilot study, we aimed to compare the results of this new modality with the standard imaging. We compared both techniques in 25 patients at the University Medical Center Utrecht, The Netherlands. Twenty-eight percent of the patients had different outcomes between both modalities. In all cases, additional HNPGLs were identified using the [68Ga]Ga-DOTATOC PET/CT, suggesting the need for further prospective research to validate this finding. If confirmed, this modality could potentially be implemented as the standard of care for HNPGL detection in germline variant carriers. The Dutch guideline for patients suspected of head and neck paragangliomas (HNPGLs) recommends magnetic resonance imaging (MRI) and/or computed tomography (CT) of the head and neck area. Additionally, it suggests considering additional nuclear imaging. The aim of this study was to evaluate the outcomes of [68Ga]Ga-DOTATOC PET/CT compared to MRI in patients with suspected HNPGLs and carriers of genetic variations. Methods: In this single-center pilot study, retrospective data were obtained from consecutive patients between 2016 and 2023. Both MRI and [68Ga]Ga-DOTATOC PET/CT were performed within 12 months. The primary outcome was the location of HNPGLs. Results: A total of 25 consecutive patients were included, and 7 patients (28.0%, p = 0.5) showed differences between the imaging modalities, of whom 5 patients had unexpected localizations with additional uptake by somatostatin receptors (SSTR) on the [68Ga]Ga-DOTATOC PET/CT. Conclusions: The authors recommend performing baseline imaging with [68Ga]Ga-DOTATOC PET/CT (if available) in variant carriers and using MRI/CT for follow-up according to the regional protocol, thereby shifting the gold standard for baseline imaging from MRI/CT to [68Ga]Ga-DOTATOC PET/CT. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Management and Outcomes of Necrotizing Otitis Externa: A Retrospective Cohort Study in a Tertiary Referral Center

Author

MS KNO, Brain, MS Radiologie, Cancer, Other research (not in main researchprogram), Vosbeek, Eleonora G M, Straatman, Louise V, Braat, Arthur J A T, de Keizer, Bart, Thomeer, Hans G X M, Smit, Adriana L, MS KNO, Brain, MS Radiologie, Cancer, Other research (not in main researchprogram), Vosbeek, Eleonora G M, Straatman, Louise V, Braat, Arthur J A T, de Keizer, Bart, Thomeer, Hans G X M, and Smit, Adriana L

Published
2023

47. Prophylactic Medication during Radioembolization in Metastatic Liver Disease: Is It Really Necessary? A Retrospective Cohort Study and Systematic Review of the Literature

Author

Cancer, MS Radiologie, Researchgr. Nucleaire Geneeskunde, Other research (not in main researchprogram), MS MDL 1, Braat, Manon N G J A, Ebbers, Sander C, Alsultan, Ahmed A, Neek, Atal O, Bruijnen, Rutger C G, Smits, Maarten L J, de Bruijne, Joep, Lam, Marnix G E H, Braat, Arthur J A T, Cancer, MS Radiologie, Researchgr. Nucleaire Geneeskunde, Other research (not in main researchprogram), MS MDL 1, Braat, Manon N G J A, Ebbers, Sander C, Alsultan, Ahmed A, Neek, Atal O, Bruijnen, Rutger C G, Smits, Maarten L J, de Bruijne, Joep, Lam, Marnix G E H, and Braat, Arthur J A T

Published
2023

48. Correction to: Imaging in rhabdomyosarcoma: a patient journey

Author

Onderzoek Beeld, Cancer, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, PMC Medisch specialisten, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, van Rijn, Rick R, Onderzoek Beeld, Cancer, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, PMC Medisch specialisten, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, and van Rijn, Rick R

Published
2023

49. Learning curve and factors influencing successful robot-assisted bilateral sentinel lymph node mapping in early-stage cervical cancer: an observational cohort study

Author

Cancer, MS Gynaecologische Oncologie, MS Radiologie, Baeten, Ilse G T, Hoogendam, Jacob P, Braat, Arthur J A T, de Keizer, Bart, Gerestein, Cornelis G, Zweemer, Ronald P, Cancer, MS Gynaecologische Oncologie, MS Radiologie, Baeten, Ilse G T, Hoogendam, Jacob P, Braat, Arthur J A T, de Keizer, Bart, Gerestein, Cornelis G, and Zweemer, Ronald P

Published
2023

50. Tolerability of concurrent external beam radiotherapy and [ 177Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial).

Author

Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, Vogel, Wouter V, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, and Vogel, Wouter V

Published
2023

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