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15 results on '"Brachwitz, Kristin"'

1. Supplementary Table 2 from Expression Profiling of t(12;22) Positive Clear Cell Sarcoma of Soft Tissue Cell Lines Reveals Characteristic Up-Regulation of Potential New Marker Genes Including ERBB3

Author

Schaefer, Karl-Ludwig, primary, Brachwitz, Kristin, primary, Wai, Daniel H., primary, Braun, Yvonne, primary, Diallo, Raihanatou, primary, Korsching, Eberhard, primary, Eisenacher, Martin, primary, Voss, Reinhard, primary, van Valen, Frans, primary, Baer, Claudia, primary, Selle, Barbara, primary, Spahn, Laura, primary, Liao, Shuen-Kuei, primary, Lee, Kevin A. W., primary, Hogendoorn, Pancras C. W., primary, Reifenberger, Guido, primary, Gabbert, Helmut E., primary, and Poremba, Christopher, primary

Published
2023
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2. Supplementary Table 1 from Expression Profiling of t(12;22) Positive Clear Cell Sarcoma of Soft Tissue Cell Lines Reveals Characteristic Up-Regulation of Potential New Marker Genes Including ERBB3

Author

Schaefer, Karl-Ludwig, primary, Brachwitz, Kristin, primary, Wai, Daniel H., primary, Braun, Yvonne, primary, Diallo, Raihanatou, primary, Korsching, Eberhard, primary, Eisenacher, Martin, primary, Voss, Reinhard, primary, van Valen, Frans, primary, Baer, Claudia, primary, Selle, Barbara, primary, Spahn, Laura, primary, Liao, Shuen-Kuei, primary, Lee, Kevin A. W., primary, Hogendoorn, Pancras C. W., primary, Reifenberger, Guido, primary, Gabbert, Helmut E., primary, and Poremba, Christopher, primary

Published
2023
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3. Data from Expression Profiling of t(12;22) Positive Clear Cell Sarcoma of Soft Tissue Cell Lines Reveals Characteristic Up-Regulation of Potential New Marker Genes Including ERBB3

Author

Schaefer, Karl-Ludwig, primary, Brachwitz, Kristin, primary, Wai, Daniel H., primary, Braun, Yvonne, primary, Diallo, Raihanatou, primary, Korsching, Eberhard, primary, Eisenacher, Martin, primary, Voss, Reinhard, primary, van Valen, Frans, primary, Baer, Claudia, primary, Selle, Barbara, primary, Spahn, Laura, primary, Liao, Shuen-Kuei, primary, Lee, Kevin A. W., primary, Hogendoorn, Pancras C. W., primary, Reifenberger, Guido, primary, Gabbert, Helmut E., primary, and Poremba, Christopher, primary

Published
2023
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5. Constitutive Activation of Neuregulin/ERBB3 Signaling Pathway in Clear Cell Sarcoma of Soft Tissue1

Author

Schaefer, Karl-Ludwig, Brachwitz, Kristin, Braun, Yvonne, Diallo, Raihanatou, Wai, Daniel H., Zahn, Susanne, Schneider, Dominik T, Kuhnen, Cornelius, Vollmann, Arabel, Brockhoff, Gero, Gabbert, Helmut E., and Poremba, Christopher

Subjects
Receptor, ErbB-3, Neuregulin-1, Oligonucleotides, Nucleic Acid Hybridization, Soft Tissue Neoplasms, Gene Expression Regulation, Neoplastic, Kinetics, Pyrimidines, Cell Line, Tumor, mental disorders, Humans, Sarcoma, Clear Cell, Phosphorylation, Alleles, Research Article, Oligonucleotide Array Sequence Analysis, Signal Transduction
Abstract

Clear cell sarcoma of soft tissue (CCSST) represents a highly malignant tumor of the musculoskeletal system that is characterized by the chromosomal translocation t(12;22)(q13;q12) of the Ewing sarcoma gene (EWSR1) and activating transcription factor 1 (ATF1). In a former microarray expression study, we identified ERBB3, a member of the epidermal growth factor receptor (EGFR) family, as a promising new diagnostic marker in the differential diagnosis of CCSST. Here we show that, besides ErbB3, all CCSST cell lines (n = 8) also express the ErbB2 receptor or the ErbB4 receptor, representing an adequate coreceptor of ErbB3. The phosphorylation status of ErbB3 revealed these receptor pairs to be either constitutively activated in CCSST cells with high neuregulin-1 (NRG1) expression (n = 4) or activatable by exogenic NRG1 in cells showing low amounts of NRG1 mRNA (n = 4). Exogenous NRG1 stimulated the growth of a subset of CCSST cells but did not affect the kinetics of another subset. This difference was not strictly dependent on endogenous NRG1 expression; however, the growth-inhibiting effect of the pan-ErbB tyrosine kinase inhibitor CI-1033 or PD158780 clearly correlated with NRG1 expression indicating an autocrine growth stimulation loop, which may constitute an interesting target of new therapeutic strategies in this tumor entity.

Published
2006

8. Microarray analysis of Ewing’s sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy

Author

Schaefer, Karl-Ludwig, primary, Eisenacher, Martin, additional, Braun, Yvonne, additional, Brachwitz, Kristin, additional, Wai, Daniel H., additional, Dirksen, Uta, additional, Lanvers-Kaminsky, Claudia, additional, Juergens, Heribert, additional, Herrero, David, additional, Stegmaier, Sabine, additional, Koscielniak, Ewa, additional, Eggert, Angelika, additional, Nathrath, Michaela, additional, Gosheger, Georg, additional, Schneider, Dominik T., additional, Bury, Carsten, additional, Diallo-Danebrock, Raihanatou, additional, Ottaviano, Laura, additional, Gabbert, Helmut E., additional, and Poremba, Christopher, additional

Published
2008
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9. Constitutive Activation of Neuregulin/ERBB3 Signaling Pathway in Clear Cell Sarcoma of Soft Tissue

Author

Schaefer, Karl-Ludwig, primary, Brachwitz, Kristin, additional, Braun, Yvonne, additional, Diallo, Raihanatou, additional, Wai, Daniel H., additional, Zahn, Susanne, additional, Schneider, Dominik T., additional, Kuhnen, Cornelius, additional, Vollmann, Arabel, additional, Brockhoff, Gero, additional, Gabbert, Helmut E., additional, and Poremba, Christopher, additional

Published
2006
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10. Expression Profiling of t(12;22) Positive Clear Cell Sarcoma of Soft Tissue Cell Lines Reveals Characteristic Up-Regulation of Potential New Marker Genes IncludingERBB3

Author

Schaefer, Karl-Ludwig, primary, Brachwitz, Kristin, additional, Wai, Daniel H., additional, Braun, Yvonne, additional, Diallo, Raihanatou, additional, Korsching, Eberhard, additional, Eisenacher, Martin, additional, Voss, Reinhard, additional, van Valen, Frans, additional, Baer, Claudia, additional, Selle, Barbara, additional, Spahn, Laura, additional, Liao, Shuen-Kuei, additional, Lee, Kevin A. W., additional, Hogendoorn, Pancras C. W., additional, Reifenberger, Guido, additional, Gabbert, Helmut E., additional, and Poremba, Christopher, additional

Published
2004
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