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10 results on '"Bradley, Marissa C."'

1. Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity

Author

Matsumoto, Rei, Gray, Joshua, Rybkina, Ksenia, Oppenheimer, Hanna, Levy, Lior, Friedman, Lilach M., Khamaisi, Muhammad, Meng, Wenzhao, Rosenfeld, Aaron M., Guyer, Rebecca S., Bradley, Marissa C., Chen, David, Atkinson, Mark A., Brusko, Todd M., Brusko, Maigan, Connors, Thomas J., Luning Prak, Eline T., Hershberg, Uri, Sims, Peter A., Hertz, Tomer, and Farber, Donna L.

Published
2023
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2. Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood

Author

Connors, Thomas J., Matsumoto, Rei, Verma, Shivali, Szabo, Peter A., Guyer, Rebecca, Gray, Joshua, Wang, Zicheng, Thapa, Puspa, Dogra, Pranay, Poon, Maya M.L., Rybkina, Ksenia, Bradley, Marissa C., Idzikowski, Emma, McNichols, James, Kubota, Masaru, Pethe, Kalpana, Shen, Yufeng, Atkinson, Mark A., Brusko, Maigan, Brusko, Todd M., Yates, Andrew J., Sims, Peter A., and Farber, Donna L.

Published
2023
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3. Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span

Author

Gray, Joshua I., primary, Caron, Daniel P., additional, Wells, Steven B., additional, Guyer, Rebecca, additional, Szabo, Peter, additional, Rainbow, Daniel, additional, Ergen, Can, additional, Rybkina, Ksenia, additional, Bradley, Marissa C., additional, Matsumoto, Rei, additional, Pethe, Kalpana, additional, Kubota, Masaru, additional, Teichmann, Sarah, additional, Jones, Joanne, additional, Yosef, Nir, additional, Atkinson, Mark, additional, Brusko, Maigan, additional, Brusko, Todd M., additional, Connors, Thomas J., additional, Sims, Peter A., additional, and Farber, Donna L., additional

Published
2024
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4. SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

Author

Rybkina, Ksenia, primary, Bell, Joseph N., additional, Bradley, Marissa C., additional, Wohlbold, Teddy, additional, Scafuro, Marika, additional, Meng, Wenzhao, additional, Korenberg, Rebecca C., additional, Davis-Porada, Julia, additional, Anderson, Brett R., additional, Weller, Rachel J., additional, Milner, Joshua D., additional, Moscona, Anne, additional, Porotto, Matteo, additional, Luning Prak, Eline T., additional, Pethe, Kalpana, additional, Connors, Thomas J., additional, and Farber, Donna L., additional

Published
2023
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9. SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Author

Poon, Maya M.L., primary, Rybkina, Ksenia, additional, Kato, Yu, additional, Kubota, Masaru, additional, Matsumoto, Rei, additional, Bloom, Nathaniel I., additional, Zhang, Zeli, additional, Hastie, Kathryn M., additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Wells, Steven B., additional, Ural, Basak B., additional, Lam, Nora, additional, Szabo, Peter A., additional, Dogra, Pranay, additional, Lee, Yoon S., additional, Gray, Joshua I., additional, Bradley, Marissa C., additional, Brusko, Maigan A., additional, Brusko, Todd M., additional, Saphire, Erica O., additional, Connors, Thomas J., additional, Sette, Alessandro, additional, Crotty, Shane, additional, and Farber, Donna L., additional

Published
2021
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10. Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells.

Author

Verma S, Bradley MC, Gray J, Dogra P, Caron DP, Maurrasse S, Grunstein E, Waldman E, Jang M, Pethe K, Farber DL, and Connors TJ

Subjects
Humans, Child, Adult, Child, Preschool, Female, Male, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Transcriptome immunology, Infant, Adolescent, Interleukin-10 immunology, CD8-Positive T-Lymphocytes immunology, Gene Expression Profiling, T-Lymphocytes, Regulatory immunology, Palatine Tonsil immunology, Palatine Tonsil cytology
Abstract

CD4+ regulatory T cells (Tregs) are key orchestrators of the immune system, fostering the establishment of protective immunity while preventing deleterious responses. Infancy and childhood are crucial periods of rapid immunologic development, but how Tregs mediate immune responses at these earliest timepoints of human life is poorly understood. In this study, we compare blood and tissue (tonsil) Tregs across pediatric and adult subjects to investigate age-related differences in Treg biology. We observed increased FOXP3 expression and proportions of Tregs in tonsil compared with paired blood samples in children. Within tonsil, early life Tregs accumulated in extrafollicular regions with cellular interactions biased toward CD8+ T cells. Tonsil Tregs in both children and adults expressed transcriptional profiles enriched for lineage defining signatures and canonical functionality compared with blood, suggesting tissue as the primary site of Treg activity. Early life tonsil Tregs transcriptional profiles were further defined by pathways associated with activation, proliferation, and polyfunctionality. Observed differences in pediatric tonsil Treg transcriptional signatures were associated with phenotypic differences, high proliferative capacity, and robust production of IL-10 compared with adult Tregs. These results identify tissue as a major driver of Treg identity, provide new insights into developmental differences in Treg biology across the human lifespan, and demonstrate unique functional properties of early life Tregs., (Copyright © 2024 by The American Association of Immunologists, Inc.)

Published
2024
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