389 results on '"Brady, Michael"'
Search Results
2. A philosophical approach to improving empirical research on posttraumatic growth.
- Author
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Brady, Michael and Jayawickreme, Eranda
- Abstract
Post-traumatic growth (PTG) has been a key topic of research by psychologists over the last 25 years. But the idea that a person can benefit from adversity has been around for much longer, and is a stable in many mainstream cultures, and in theological and recent philosophical thinking. However, there has been, to date, little overlap between psychological research into PTG, and philosophical thinking about similar ideas. This is unfortunate, both because philosophers are not taking up potential sources of empirical support, and because psychological research into PTG is subject to a range of criticisms and concerns. In this paper, we aim to show how philosophical thinking can address some of these, and as a result put psychological research into PTG on a firmer theoretical footing. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Alumina-forming austenitic stainless steel for high durability and chromium-evaporation minimized balance of plant components in solid oxide fuel cells.
- Author
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Zhou, Lingfeng, Brady, Michael P., Li, Wenyuan, Eldred, Tim B., Garcia, Roberto, Zeng, Zhipeng, Ma, Liang, Wang, Yi, Hu, Shanshan, and Liu, Xingbo
- Subjects
- *
AUSTENITIC stainless steel , *SOLID oxide fuel cells , *OXIDATION kinetics - Abstract
The chromium evaporation and oxidation behaviors of alumina-forming austenitic stainless steels are systematically investigated at 800 °C in air +10% H 2 O relative to 310S for 5000 h. Cr evaporation rates of 310S are about 35 times higher than AFA alloys after 5000 h. Relatively rapid oxidation is observed on 310S after only one 500 h cycle, followed by a modest degree of mass loss and spallation, while the AFA alloys show high oxidation resistance throughout the entire test. Continuous inner alumina layer formed on AFA alloys stays compact and stable after 5000 h which greatly reduces the Cr evaporation. • Long-term Cr evaporation rates of various alloys were reported. • Oxidation kinetic of AFA alloys compared to 310S were studied. • Continuous alumina layer formed on AFA alloys remained durable after 5000 h test. • Effect of Si contamination on the Cr evaporation rates were discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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4. Suffering in sport: why people willingly embrace negative emotional experiences.
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Brady, Michael S.
- Subjects
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SPORTS , *EMOTIONAL experience , *SUFFERING , *DISAPPOINTMENT , *SHAME , *DESPAIR - Abstract
Nearly everyone agrees that physical pain is bad. Indeed, if anything merits the status of a platitude in our everyday thinking about value, the idea that pain is bad surely does. Equally, it seems clearly true that emotional suffering – despair, loneliness, grief, disappointment, guilt, shame, lovesickness, and the like – are all bad as well. We are strongly inclined to pity and feel sorry for those who suffer emotionally in these ways; we are motivated, at least some of the time, to do what we can to alleviate their suffering. Given this, it might seem curious that pain and suffering are so integral to sport – whether one is a participant or a spectator. There's nothing particularly puzzling about pain and suffering that is inadvertently related to sport – as when an athlete injures her hamstring and has to miss her chance at Olympic glory, or when supporters face the misery of getting up at 6am because an away game has been scheduled to start at noon. But there does seem to be something curious about the extent to which pain and suffering are voluntarily embraced by participants and spectators, as the quotation from Nick Hornby aptly illustrates. Why do people willingly engage in something that brings about so much suffering? In this paper, I'll attempt to answer this question.1 [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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5. Small Group-Delivered Literacy Based Behavioral Interventions for Young Children.
- Author
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Pistorio, Kalynn Hall, Brady, Michael P., Kearney, Kelly, Darling, Sharon, Bucholz, Jessica, and Finnegan, Lisa A.
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LITERACY , *FINE motor ability , *MOTOR ability , *PRESCHOOL teachers , *DEVELOPMENTAL delay , *KINDERGARTEN - Abstract
Many differences exist between preschool and kindergarten classrooms, including the type and time spent on fine motor activities. Children at risk for developmental delays and learning challenges as they transition to kindergarten often require direct support during preschool to learn new skills needed for kindergarten. This study expanded the storybook literacy based behavioral intervention (LBBI) research by exploring the effect of small group-delivered, electronic LBBIs on preschool students considered at-risk by their teachers. Using a multiple probe design across skills, we delivered LBBIs in a small group to teach common fine motor classroom skills (cutting with scissors, using liquid glue, and matching using one-to-one correspondence). Children acquired and maintained the new skills, then generalized the motor skills to novel materials. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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6. An alternative, curriculum-based value-added model for teacher preparation programmes: a research summary.
- Author
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Brady, Michael P.
- Subjects
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TEACHER education , *CURRICULUM-based assessment , *EFFECTIVE teaching , *STUDENT evaluation of curriculum - Abstract
Teacher preparation programmes (TPPs) find many ways to shape the development of their teacher candidates while bridging the research to practice gap in university and school partnerships. Recently, accountability models built on high-stakes standardised student assessments (Value-Added Models [VAM]) have been mandated as a way to evaluate the effectiveness of teacher and teacher preparation efforts. Adopting a metric with known validity and reliability flaws has unintended consequences that affect teachers, TPPs, and K-12 students. This article examines the current climate surrounding teacher and TPP evaluation, and presents the unintended consequences of using a flawed metric for VAM efforts. The article provides a rationale for an alternative, curriculum-based VAM for TPPs, and summarises a series of four investigations that explored this model and serve as a rationale for further implementation by other TPPs. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Are We There Yet? An Emerging Research Agenda for College Students with Intellectual and Developmental Disabilities.
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Brady, Michael P.
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COLLEGE students , *DEVELOPMENTAL disabilities , *PEOPLE with intellectual disabilities , *RESEARCH , *SPECIAL education - Abstract
There is a distinct need for a research agenda that drives research, practice, and policy for college students with intellectual and developmental disabilities. This paper provides a brief summary of the rapid growth of college programs in the absence of any organized research agenda. A research framework and agenda is proposed, and a brief summary of each of the papers in the special issue is provided. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Coordination and Party Change in the United States.
- Author
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Lee, Daniel J. and Brady, Michael
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UNITED States political parties , *CAMPAIGN issues , *POLITICAL sociology , *POLITICAL platforms , *POLITICAL leadership , *POLITICAL affiliation , *POLITICAL science - Abstract
The ability of American political parties to change issue positions is potentially hindered by problems of coordination. Research on parties since the 1990s has shown what tools party leadership can use to enforce discipline and cohesion among its ranks. We, however, question whether those theories of party control, which explain party stability, can straightforwardly explain party change. Oftentimes we think of parties strategically altering issue positions, but what is "the party?" Rather than a monolithic group, American parties are relatively decentralized, weak, and individualistic compared with other party systems. We present an evolutionary game theoretic example to illustrate the problem of coordination in party change. This theoretical framework suggests an empirical focus on individual-level behaviors to better understand the dynamics of party change. We analyze roll call voting of members of Congress on the environment and abortion to illustrate micro-level behaviors suggested by our theoretical discussion. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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9. The Roles of Gender and Marital Status on Risky Asset Allocation Decisions.
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Mandal, Bidisha and Brady, Michael P.
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ASSET allocation , *MARITAL status , *GENDER role , *INDIVIDUAL retirement accounts , *MARRIED men - Abstract
We analyze data on asset allocations in individual retirement accounts to examine the roles of marital status and gender on investment decisions. We utilize data from two birth cohorts to understand the relationship over a wide age range. We find that, in their 30s and early 40s, men are more likely to hold a majority of their funds in stocks in individual retirement accounts compared to women. The gender difference disappears around retirement age; however, a significant difference by marital status emerges in that age group. Divorced and widowed individuals are less likely to hold a majority of their funds in stocks compared to married individuals in their 60s. While there exists a positive gap in stock holdings between married men and married women in their 30s, the gender gap is nonexistent among older individuals. Using paired data on stock holdings in the older birth cohort, we show that husbands' and wives' asset allocations in individual retirement accounts are strongly correlated, coinciding with the lack of a gender gap in stock holdings among older couples. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Mitigating Groundwater Impacts of Residential Wells through Small‐Scale Distributed Storage in the Skagit River Basin.
- Author
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Brady, Michael P., Padowski, Julie, Yoder, Jonathan K., Jessup, Eric, Christensen, David, Yang, Qingqing, and Anderson, Barbara
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WATERSHEDS , *GROUNDWATER , *WATER supply , *INSTREAM flow , *WATER , *WATER storage - Abstract
The exemption for groundwater wells for residential uses from the prior appropriations system, common in the western United States, has eroded in Washington State since about 2000 due to a series of legal cases. Water markets can allow the transfer of an existing water right, typically from an agricultural use, to compensate for the effect of a new residential well. But water must be legally and physically available in a way suitable to satisfy mitigation requirements. A recent court case in the Skagit basin in Northwestern Washington State has effectively halted residential development in rural areas of the basin because no suitable water rights are available to purchase for mitigation. This paper presents and examines the cost‐effectiveness of various water supply mitigation strategies. We find a small‐scale, distributed stream‐side storage system for augmenting instream flow purchased from downstream sources is relatively cost‐effective to mitigate against the effects of domestic groundwater use compared to more common alternatives. We consider transporting water to storage sites by both small‐gauge pipe and by truck. Overall, trucking water to stream‐side storage and release points tends to be more cost‐effective to mitigate against indoor‐use only given current subbasin housing densities, whereas piping for direct streamflow augmentation is more cost‐effective for higher mitigation needs associated with indoor and outdoor use and higher housing densities. Research Impact Statement: Small‐scale water storage is a cost‐effective approach for offsetting the impact of domestic wells on surface water rights. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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11. Using literacy-based behavioural interventions to teach self-regulation skills to young children.
- Author
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Hall Pistorio, Kalynn, Brady, Michael P., and Morris, Cindy
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DEVELOPMENTAL delay , *SELF regulation , *PRESCHOOL children , *ELECTRONIC books , *HOME environment , *ABILITY , *TEACHING aids - Abstract
Many young children receive developmental screenings because they do not perform basic self-regulation skills needed in preschool and home environments. Previous research on Literacy-Based Behavioural Interventions (LBBI) shows promise for promoting acquisition and maintenance of skills and routines; however, research has not yet examined the effectiveness of this intervention for self-regulation for young children. In this study, four children aged 2–4 referred for developmental screenings received an electronic LBBI story highlighting a visual timer to help them self-regulate. Results showed their self-regulation skills increased dramatically after using the LBBI stories with the timer, with strong effect sizes. These skills also generalized to other settings and increased engagement in activity and literacy centres. Three children maintained these skills after the LBBI was removed. This study extends previous research, incorporating an electronic book as the LBBI, and showing intervention effectiveness with young children not previously included in LBBI research. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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12. Improved Assessment of Chromium Evaporation Rates in Solid Oxide Cell Balance of Plant Component Alloys.
- Author
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Zhou, Lingfeng, Li, Wenyuan, Brady, Michael P., Zeng, Zhipeng, Ma, Liang, Wang, Yi, Hu, Shanshan, and Liu, Xingbo
- Subjects
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CHROMIUM , *ALLOYS , *SILICON alloys , *SODIUM carbonate , *OXIDES , *AUSTENITIC steel - Abstract
The chromium (Cr) evaporation from balance-of-plant (BoP) component alloys in high-temperature environments can severely deteriorate the electrochemical performance of solid oxide cells (SOCs) in fuel (SOFC) and electrolysis (SOEC) modes. However, accurate assessment of Cr evaporation is challenging due to potential interferences from the experimental conditions and test apparatus. In this study, we investigate four distinct methods for assessing the Cr evaporation rates of candidate alumina-forming austenitic and chromia-forming austenitic BoP alloys under relevant simulated SOC operating conditions of 800–900 °C in air with 10% H2O. A method using a sodium carbonate coated thin alumina tube is identified, which effectively mitigates the interference caused by (1) the deposition of silicon deposits originating from quartz furnace tubes, (2) detrimental effects of sodium species on the oxidation process of alloys from the sodium carbonate used to enhance Cr oxy hydroxide species capture, or (3) chemical interaction between Cr gaseous species and the alumina furnace tube. This optimal method provides improved assessment of Cr evaporation, enabling further efforts to build correlation between Cr species quantities to the degradation rates of SOCs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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13. Antecedent factors influencing ethics-related social and socio-scientific learning enjoyment.
- Author
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Tsai, Chun-Yen and Jack, Brady Michael
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ETHICS associations , *MORAL judgment , *SCIENCE classrooms , *SCIENCE education , *CLASSROOM environment - Abstract
This study investigates how affective dispositions influencing students' moral judgments can both shape their response to individual enjoyment from learning ethics (IE-LE) and predict their individual enjoyment from learning socio-scientific issues (IE-LSSI). Tenth-grade participants from southern Taiwan (n = 770) responded to survey items that support four subscales: science classroom, news media, IE-LE and IE-LSSI. Structural equation modelling analyses of these subscales found them to be empirically separable, structurally reliable and valid for investigating how students' affective and self-related cognitive responses can predict their self-evaluated state of IE-LE and IE-LSSI. Viewed from the impact contribution of science classroom and news media, learning enjoyment plays a pivotal role in igniting and sustaining students' personal attention when discussing IE-LE and IE-LSSI in the classroom. The implication of this study is that by encouraging students to think ethically about issues of science and allowing them to investigate SSI-related issues from a variety of news media sources within the classroom context, teachers can provide opportunity for students to explore science issues that may be well connected to their personal enjoyment of ethics and sense of freedom to learn within a science-related classroom environment. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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14. Using Peer-Mediated Literacy-Based Behavioral Interventions to Increase First Aid Safety Skills in Students With Developmental Disabilities.
- Author
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Kearney, Kelly B., Brady, Michael P., Hall, Kalynn, and Honsberger, Toby
- Subjects
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EDUCATION of children with disabilities , *WOUND care , *BEHAVIOR therapy , *FIRST aid in illness & injury , *INTERPERSONAL relations , *LITERACY , *STORYTELLING , *SURGICAL dressings , *TEACHING methods ,TREATMENT of developmental disabilities ,RESEARCH evaluation - Abstract
Many adolescents with developmental disabilities do not learn the safety skills needed to maintain physical well-being in domestic and community environments. Literacy-based behavioral interventions (LBBIs) that combine print, pictures, and behavioral rehearsal are effective for promoting acquisition and maintenance of self-care skills, but have not been investigated as safety skill intervention. Also, LBBIs have primarily been implemented by teachers and other professionals. In this study, a peer partner was taught to deliver an LBBI story to students so they would learn to perform a basic first aid routine: cleaning and dressing a wound. Results showed that students’ accuracy with the first aid routine increased after a peer delivered the LBBI instructional package, and maintained after the peer stopped delivering it. This study demonstrates the effectiveness of the LBBI instructional package for teaching first aid safety skills, and extends previous research showing the efficacy of peers in delivering this intervention. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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15. Warning! Increases in interest without enjoyment may not be trend predictive of genuine interest in learning science.
- Author
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Jack, Brady Michael and Lin, Huann-shyang
- Subjects
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EDUCATIONAL psychology , *INTEREST (Psychology) , *SCIENCE education -- Social aspects , *SCIENCE education research , *PSYCHOLOGY of learning - Abstract
Highlights • Evidence on how science-related affect and competency factors predict environmental awareness. • Suggestions why increases in science interest do not necessarily reflect a genuine interest in learning science. • PISA 2006/2015 comparisons within/between 2 Asian countries reveal divergent predictive trends. • These trends may reflect antithetic instruction approaches preventing genuine learning interest. Abstract Utilizing PISA 2006/2015 datasets for Japan and Taiwan, the multi-group analysis results show significant predictive increases in science interest and scientific competency, and for science interest and environmental awareness; however, revealed significant predictive decreases for science enjoyment and scientific competency, and for science enjoyment and environmental awareness between PISA cycles for both countries. Results signal divergent predictive trends regarding how interest and enjoyment impact students’ scientific competency, which may reflect instructional approaches that impede students from experiencing genuine interest in learning science. Why these results should sound an alarm to science and environment educators and policy makers is also forwarded. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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16. The Emerging Role of BIOGRIDS.
- Author
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Ellisman, Mark, Brady, Michael, Hart, David, Fang-Pang Lin, Müller, Matthias, and Smarr, Larry
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MEDICAL care , *LIFE sciences , *NEUROLOGY , *EMERGENCY medical services , *GRID computing - Abstract
The article focuses on the role of Biogrids in the delivery of health care and in the understanding of evolutionary processes. Biogrids are increasingly important in the development of new computing applications for the life sciences and in providing immediate medical benefits to individual patients and even to those only at risk of getting sick. The development of targeted grids providing practical solutions to individual problems is also important in the overall development of grid technology, providing immediate, visible rewards from the continuing investment. The article explores four grid projects designed for specific biomedical issues: the SARSGrid for a global medical emergency; the eScience Diagnostic Mammography National Database project to develop a grid-enabled database of annotated mammograms; a temporary global grid constructed as a demonstration project to analyze arthropod evolution called the GliederfüsslerGrid; and the Biomedical Informatics Research Network devoted to neurology.
- Published
- 2004
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17. Long-term oxidation and chromium evaporation behavior of Al2O3-forming austenitic stainless steel for 900 °C balance-of-plant components applications in solid oxide fuel cells.
- Author
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Zhou, Lingfeng, Li, Wenyuan, Brady, Michael P., Eldred, Tim B., Garcia, Roberto, Ma, Liang, Wang, Yi, Hu, Shanshan, Li, Wei, and Liu, Xingbo
- Subjects
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AUSTENITIC stainless steel , *ENERGY dispersive X-ray spectroscopy , *SCANNING transmission electron microscopy , *CHROMIUM , *SOLID oxide fuel cells , *OXIDATION kinetics - Abstract
The long-term operation of balance-of-plant (BoP) components in solid oxide fuel cells (SOFCs) relies on the presence of a stable and durable oxide layer. In this study, we investigate the oxidation and chromium (Cr) evaporation behaviors of two developmental alumina-forming austenitic (AFA) alloys compared to chromia-forming alloy 625 at 900 °C in air with 10% water vapor. Transpiration tests, weight gain tests, X-ray diffraction, scanning electron microscopy with energy dispersive X-ray analysis, and scanning transmission electron microscopy with energy dispersive X-ray analysis are employed to evaluate the oxidation and Cr evaporation behaviors. Our findings reveal that alloy 625 exhibits significantly higher rates of Cr evaporation compared to OC11 (Y and Hf additions) and OC11LZ (Y and Zr additions), with evaporation amounts ∼56 and ∼28 times greater, respectively. The observed differences between OC11 and OC11LZ can be attributed to variations in the formed oxide scales during long-term operation. Furthermore, we examine the influence of Hf and Zr reactive elements on the long-term oxidation and chromium evaporation behaviors, providing insights into the role of these elements in enhancing the performance and stability of the alloys. • Long-term oxidation and Cr evaporation characteristics of different alloys were documented. • Oxidation kinetics of AFA alloys were investigated in comparison to alloy 625. • Continuous alumina layer formed on AFA alloys exhibited long-term durability even after a 5000-h test. • Impact of reactive elements on the growth of oxide scales was discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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18. A Rational and Manageable Value-Added Model for Teacher Preparation Programs.
- Author
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Brady, Michael P., Miller, Katie, McCormick, Jazarae, and Heiser, Lawrence A.
- Subjects
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EDUCATORS , *TEACHER education , *EDUCATIONAL accreditation , *RATING of students , *VALUE-added assessment (Education) - Abstract
Educators struggle with “value-added” teacher evaluation models based on high-stakes student assessments. Despite validity and reliability threats, these models evaluate university-based teacher preparation programs (TPPs), and play a role in state and professional accreditation. This study reports a more rational value-added evaluation model linking student performance to teacher candidates’ lessons during Practicum and Student Teaching. Results indicate that K-12 students showed learning gains on these lessons, with mixed findings on comparisons of part-time to full-time internships, academic and functional lessons, and candidates’ grade point averages (GPAs). Results indicated that teacher candidates’ lessons are a viable value-added model (VAM) alternative for TPPs. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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19. PAINFULNESS, DESIRE, AND THE EUTHYPHRO DILEMMA.
- Author
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Brady, Michael S.
- Subjects
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DESIRE , *DILEMMA , *SENSE (Philosophy) , *AMERICAN philosophy , *PAIN perception - Abstract
The traditional desire view of painfulness maintains that pain sensations are painful because the subject desires that they not be occurring. A significant criticism of this view is that it apparently succumbs to a version of the Euthyphro Dilemma: the desire view, it is argued, is committed to an implausible answer to the question of why pain sensations are painful. In this paper, I explain and defend a new desire view, and one which can avoid the Euthyphro Dilemma. This new view maintains that painfulness is a property, not of pain sensations, but of a pain experience, understood as a relational state constituted by a pain sensation and a desire that the sensation not be occurring. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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20. Making learning interesting and its application to the science classroom.
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Jack, Brady Michael and Lin, Huann-shyang
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SCIENCE classrooms , *SCIENCE education (Secondary) , *CLASSROOM learning centers , *TEACHING methods , *AUTONOMY (Psychology) , *SCHOOL children , *SECONDARY school students , *SECONDARY education - Abstract
Generations of students are graduating from secondary school disinterested in post-secondary study of science or pursuing careers in science-related fields beyond formal education. We propose that destabilising such disinterest among future students requires science educators to begin listening to secondary school students regarding their views of how science learning is made interesting within the science classroom. Studies on students’ interest in response to instructional strategies applied in the classroom communicate the opinions (i.e. the ‘voice’) of students about the strategies they believe make their classroom learning interesting. To this end, this scoping study (1) collects empirical studies that present from various science and non-science academic domains students’ views about how to make classroom learning interesting; (2) identifies common instructional strategies across these domains that make learning interesting; and (3) forwards an instructional framework called TEDI ([T]ransdisciplinary Connections; Mediated [E]ngagement; Meaningful [D]iscovery; and Self-determined [I]nquiry), which may provide secondary school science teachers with a practical instructional approach for making learning science genuinely interesting among their students within the secondary school science classroom context. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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21. The Current Environment of Online Assessment Appeal Systems.
- Author
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BRADY, MICHAEL and SANDERSON, RICHARD L.
- Subjects
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VALUATION of real property , *REAL property tax , *INTERNET surveys , *VALUATION , *REAL property & taxation , *ACTIONS & defenses (Law) - Abstract
online assessment appeal (OAA) systems that we identified as having been implemented by assessment jurisdictions in the United States or Canada for real property assessments or in 2015 or earlier. Using online questionnaires to survey assessment jurisdictions that had implemented such systems, we develop patterns of variation that appear at the present time. While assessment jurisdictions in most states and provinces are just beginning to implement OAA systems, 98 percent of Texas counties (249 of 254) had implemented OAA systems and 20 counties in Florida, or nearly 30 percent of their 67 counties, had such systems. Data collected indicate that larger assessment jurisdictions appear to have sufficient appeal volume, staffing, IT capacity, and other needed resources to implement OAA systems. [ABSTRACT FROM AUTHOR]
- Published
- 2017
22. Literacy-based behavioural interventions delivered by peers: a teaching strategy for students with severe disabilities.
- Author
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Brady, Michael P., Hall, Kalynn, and Bielskus-Barone, Kristina
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EDUCATION of students with disabilities , *BEHAVIOR disorders in children , *TEACHING methods , *LEARNING , *SCHOOL environment - Abstract
Many children with severe disabilities do not perform basic daily living skills needed for typical school and home environments. Previous research on literacy-based behavioural interventions (LBBIs) has shown promise for promoting skill acquisition and maintenance in some learners; however, only one study has examined the effectiveness of this intervention when delivered by peers. In this study, peer classmates were taught to deliver an LBBI story that highlighted hand-washing skills in three students with severe disabilities. Results showed that the accuracy of students’ new skills increased dramatically after their peers delivered the stories with pictures and printed words, and these skills maintained after the LBBI stories were removed. Further, each of the students demonstrated accurate hand-washing in novel environments using different sinks. This study builds on previous LBBI studies by incorporating peers into the story delivery, and using the intervention to teach new self-care skills. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
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23. Role of Solution Structure in Self-Assembly of Conjugated Block Copolymer Thin Films.
- Author
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Brady, Michael A., Sung-Yu Ku, Perez, Louis A., Cochran, Justin E., Schmidt, Kristin, Weiss, Thomas M., Toney, Michael F., Ade, Harald, Hexemer, Alexander, Cheng Wang, Hawker, Craig J., Kramer, Edward J., and Chabinyc, Michael L.
- Subjects
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BLOCK copolymers , *CONJUGATED polymers , *POLYMER films , *MOLECULAR self-assembly , *SOLUTION (Chemistry) , *NANOSTRUCTURED materials , *SOLAR cells - Abstract
Conjugated block copolymers provide a pathway to achieve thermally stable nanostructured thin films for organic solar cells. We characterized the structural evolution of poly(3-hexylthiophene)-block-poly(diketopyrrolopyrrole-terthiophene) (P3HT-b-DPPT-T) from solution to nanostructured thin films. Aggregation of the DPPT-T block of P3HT-b-DPPT-T was found in solution by small-angle X-ray scattering with the P3HT block remaining well-solvated. The nanostructure in thin films was determined using a combination of wide and small-angle X-ray scattering techniques as a function of processing conditions. The structure in solution controlled the initial nanostructure in spin-cast thin films, allowing subsequent thermal annealing processes to further improve the ordering. In contrast to the results for thin films, nanostructural ordering was not observed in the bulk samples by small-angle X-ray scattering. These results suggest the importance of controlling solvent induced aggregation in forming nanostructured thin films of conjugated block copolymers. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
24. Another tool in the party toolbox? Tracing the strategic expansion of committee size in the US House, 1947–2010.
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Brady, Michael C. and Lee, Daniel
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COMMITTEES , *POLITICAL parties , *DECISION making in government policy , *IDEOLOGY , *LEGISLATOR attitudes , *POLITICAL participation - Abstract
We consider whether the manipulation of committee sizes can serve as a strategic tool of the majority party to further its influence over policy outcomes in the US House. Previous research notes the influence of the majority party’s preferences on the composition of committees but takes the size of committees as exogenous. We argue that the determination of sizes is an important first step and potential tool to shape committee composition, given vacancy constraints like the property rights norm. Using assignment and revealed legislator ideology data from the 80th to 111th Congresses, our results support this view of strategic expansion as a majority party strategy particularly for “prestige committees,” which are most central to a party’s agenda. Expansion indeed results in committees that are ideologically closer to the majority caucus median. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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25. Monolithic translucent BaMgAl10O17:Eu2+ phosphors for laser-driven solid state lighting.
- Author
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Cozzan, Clayton, Brady, Michael J., O'Dea, Nicholas, Levin, Emily E., Shuji Nakamura, DenBaars, Steven P., and Seshadri, Ram
- Subjects
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LIGHT emitting diodes , *VISIBLE spectra , *PHOSPHORS - Abstract
With high power light emitting diodes and laser diodes being explored for white light generation and visible light communication, thermally robust encapsulation schemes for color-converting inorganic phosphors are essential. In the current work, the canonical blue-emitting phosphor, high purity Eu-doped BaMgAl10O17, has been prepared using microwave-assisted heating (25 min) and densified into translucent ceramic phosphor monoliths using spark plasma sintering (30 min). The resulting translucent ceramic monoliths convert UV laser light to blue light with the same effi- ciency as the starting powder and provide superior thermal management in comparison with silicone encapsulation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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26. Structural and spectroscopic insight into the metal binding properties of the o-aminophenol-N,N,O-triacetic acid (APTRA) chelator: implications for design of metal indicators.
- Author
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Brady, Michael, Piombo, Sebastian D., Hu, Chunhua, and Buccella, Daniela
- Subjects
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ACETIC acid , *FLUORESCENCE , *MAGNESIUM ions , *CATIONS , *CALCIUM ions - Abstract
The o-aminophenol-N,N,O-triacetic acid (APTRA) chelator is employed extensively as a metal-recognition moiety in fluorescent indicators for biological free Mg2+, as well as in low-affinity indicators for the detection of high levels of cellular Ca2+. Despite its widespread use in sensor design, the limited metal selectivity of this chelating moiety can lead to binding of competing cations that complicate the fluorescence-based detection of metals of interest in complex samples. Reported herein are the structural characterization of APTRA complexes with various biologically relevant cations, and the thermodynamic analysis of complex formation with Mg2+, Ca2+ and Zn2+. Our results indicate that the low affinity of APTRA for Mg2+, which makes it a suitable metal-recognition moiety for sensitive analysis of typical millimolar levels of this metal in cells, stems from a much higher enthalpic cost of Mg2+ binding compared to that of other cations. The results are discussed in the context of indicator design, highlighting the aspects that may aid the future development of fluorescent sensors with enhanced metal selectivity profiles. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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27. Resonant soft X-ray scattering for polymer materials.
- Author
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Liu, Feng, Brady, Michael A., and Wang, Cheng
- Abstract
Resonant Soft X-ray Scattering (RSoXS) was developed over the last a few years, and the first dedicated resonant soft X-ray scattering beamline for soft materials was constructed at the Advanced Light Source, LBNL. RSoXS combines soft X-ray spectroscopy with X-ray scattering and thus offers statistical information for 3D chemical morphology over a large length scale range from nanometers to micrometers. Using RSoXS to characterize multi-length scale soft materials with heterogeneous chemical structures, we have demonstrated that soft X-ray scattering is a unique complementary technique to conventional hard X-ray and neutron scattering. Its unique chemical sensitivity, large accessible size scale, molecular bond orientation sensitivity with polarized X-rays, and high coherence have shown great potential for chemically specific structural characterization for many classes of materials. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
28. It Is Time to Create a Remedy to Quickly Discharge Exaggerated Mechanic's Liens in New York.
- Author
-
BRADY, MICHAEL
- Subjects
- *
COMMERCIAL law , *COMMERCIAL law -- Government policy , *COMMERCIAL law reform , *COURSE of business (Law) , *ECONOMIC laws - Abstract
The article argues that to promote private and public infrastructure development, New York courts need to broaden their interpretations of section 39 of the New York Lien Law and look to neighboring states for key principles that New York can use to improve its lien law. Topics discussed include history and background of American lien law; issues and economic impact that exaggerated mechanic's liens have on lienees; and ways in which New York combats willfully exaggerated liens.
- Published
- 2016
29. Newborn Male Circumcision with Parental Consent, as Stated in the AAP Circumcision Policy Statement, Is Both Legal and Ethical.
- Author
-
Brady, Michael T.
- Subjects
- *
CIRCUMCISION laws , *CIRCUMCISION , *NEWBORN infant care , *HIV prevention , *PARENTAL consent (Medical law) , *ETHICS , *SEXUAL health , *EVIDENCE-based medicine - Abstract
The article discusses the legal and ethical aspects of newborn male circumcision in the U.S. with parental consent, through referencing evidence-based guidelines by the American Academy of Pediatrics (AAP). The role that male circumcision plays in decreasing the risk of diseases, including of penile cancer, increasing sexual health and reducing the risk of the HIV virus, is discussed.
- Published
- 2016
- Full Text
- View/download PDF
30. Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports.
- Author
-
Fox, Julie, Brady, Michael, Alexander, Hannah, Davies, Olubanke, Robinson, Nicola, Pace, Mathew, Else, Laura, Cason, John, Khoo, Saye, Back, David, Fidler, Sarah, and Frater, John
- Subjects
- *
AIDS treatment , *HIV infections , *ANTIRETROVIRAL agents , *DRUG approval , *MEN who have sex with men - Abstract
The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP in men who have sex with men (MSM). We report two cases of TDF PrEP failure in MSM who had received long-term TDF for hepatitis B infection and had therapeutic levels of drug immediately after HIV acquisition. Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
31. Significance of miscibility in multidonor bulk heterojunction solar cells.
- Author
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Hartmeier, Benjamin F., Brady, Michael A., Treat, Neil D., Robb, Maxwell J., Mates, Thomas E., Hexemer, Alexander, Wang, Cheng, Hawker, Craig J., Kramer, Edward J., and Chabinyc, Michael L.
- Subjects
- *
SOLAR cells , *POLY(3-hexylthiophene) , *MISCIBILITY , *HETEROJUNCTIONS , *FULLERENE derivatives , *PYRROLE derivatives , *ELECTRON donor-acceptor complexes , *SMALL-angle X-ray scattering - Abstract
ABSTRACT Ternary organic blends have potential in realizing efficient bulk heterojunction (BHJ) organic solar cells by harvesting a larger portion of the solar spectrum than binary blends. Several challenging requirements, based on the electronic structure of the components of the ternary blend and their nanoscale morphology, need to be met in order to achieve high power conversion efficiency in ternary BHJs. The properties of a model ternary system comprising two donor polymers, poly(3-hexylthiophene) (P3HT) and a furan-containing, diketopyrrolopyrrole-thiophene low-bandgap polymer (PDPP2FT), with a fullerene acceptor, PC61BM, were examined. The relative miscibility of PC61BM with P3HT and PDPP2FT was examined using diffusion with dynamic secondary ion mass spectrometry (dynamic SIMS) measurements. Grazing incidence small and wide angle X-ray scattering analysis (GISAXS and GIWAXS) were used to study the morphology of the ternary blends. These measurements, along with optoelectronic characterization of ternary blend solar cells, indicate that the miscibility of the fullerene acceptor and donor polymers is a critical factor in the performance in a ternary cell. A guideline that the miscibility of the fullerene in the two polymers should be matched is proposed and further substantiated by examination of known well-performing ternary blends. The ternary blending of semiconducting components can improve the power conversion efficiency of bulk heterojunction organic photovoltaics. The blending of P3HT and PDPP2FT with PC61BM leads to good absorptive coverage of the incident solar spectrum and cascading transport energy levels. The performance of this ternary blend reveals the impact of the miscibility of PC61BM in each polymer as a function of composition, highlighting an important factor for optimization of ternary BHJs. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 237-246 [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
32. Adoption of labor-enhancing technologies by specialty crop producers.
- Author
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Gallardo, R. Karina and Brady, Michael P.
- Subjects
- *
AGRICULTURAL productivity , *SIMULATION methods & models - Abstract
Purpose – The purpose of this paper is twofold, first: to define the profile of adopters of labor-enhancing technologies (e.g. platforms) identifying factors – such as operations size, mix of fruits grown, apple operation location, principal operators socio-demographics – and second: to estimate the efficiency threshold for platform adoption during apple harvesting to be financially feasible considering future increases in farm labor wages. Design/methodology/approach – The authors conducted a mixed-mode survey in January-February 2010. Data were analyzed using a bivariate probit model, considering that the decision to adopt platforms was related with the orchard planting system. The authors conducted simulation scenarios to estimate the efficiencies – harvest – platforms must achieve in order to be economically feasible. Findings – In total, 11 percent of the 316 apple operations covered by the survey used platforms. Orchard operations most likely to invest in planar structures are relatively large, produce high-value varieties, use organic systems, and have relatively young and educated operators. Similarly, operations producing high-value fruit such as “Honeycrisp” and controlled or patented varieties and relatively large operations are more likely to invest in platforms. The results of the comparison of the cost of harvesting apples using platforms vs ladders under several production assumptions indicate that platforms must increase labor productivity by at least 13 percent in order to be adopted by the industry. Research limitations/implications – This study caveat is the lack of inclusion of production and marketing uncertainties in the estimation of future apple harvest costs. Further research to deeper analyze these issues is needed. Practical implications – The authors present information on the profile of mechanization adopters, so extension educators and engineers could concentrate efforts on them to increase adoption levels. In addition the authors provide a threshold of efficiencies for harvest platforms associated with cost savings compared to manual harvest. Social implications – Enabling the adoption of mechanization technologies by specialty crop industries would decrease the dependence on labor, decreasing labor uncertainties and facilitating the production of high quality produce to satisfy the needs of consumers. Second, it will end an era of importing poverty, given that the specialty crop industry has long benefited from seasonal migrant workers. It will improve rural American communities to shorten pools of farm workers, giving them access to permanent jobs with higher salaries. Originality/value – The contribution of this study is to improve understanding of the degree of mechanization, financial feasibility of current existing technologies, and barriers to greater mechanization by the Washington apple industry. Given the similar labor challenges faced, in general, by the US specialty crop agriculture, results could be applicable to the entire industry. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
33. The Columbia River Treaty Renegotiation from the Perspective of Contract Theory.
- Author
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Brady, Michael, Li, Tongzhe, and Yoder, Jonathan
- Subjects
- *
RENEGOTIATION , *CONTRACT theory , *CLIMATE change , *CONTRACTS ,COLUMBIA River Treaty (1964) - Abstract
This paper contributes to the literature on transboundary water agreements by analyzing the Columbia River Treaty renegotiation from the perspective of contract theory. Contract theory has become a powerful part of the economics toolbox but it is much less well known outside of the discipline than game theory. We demonstrate the importance of the concept of contract completeness in identifying efficient contractual arrangements that can consider the tradeoffs of increased flexibility. The limited objectives of the first treaty meant that it was possible to write a complete contract. Climate change and more complex stakeholder interests have moved any future agreement into the realm of incomplete contracts. Alternative types of incomplete contracts are considered as potential future treaty arrangements. The approach used in this study should provide a more general framework for working through potential treaty designs from an efficiency standpoint. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
34. Shape Description and Matching Using Integral Invariants on Eccentricity Transformed Images.
- Author
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Janan, Faraz and Brady, Michael
- Subjects
- *
COMPUTER vision , *MEDICAL imaging systems , *GEODESIC distance , *HISTOGRAMS , *COMPUTER-aided design , *ISOMETRICS (Mathematics) - Abstract
Matching occluded and noisy shapes is a problem frequently encountered in medical image analysis and more generally in computer vision. To keep track of changes inside the breast, for example, it is important for a computer aided detection system to establish correspondences between regions of interest. Shape transformations, computed both with integral invariants (II) and with geodesic distance, yield signatures that are invariant to isometric deformations, such as bending and articulations. Integral invariants describe the boundaries of planar shapes. However, they provide no information about where a particular feature lies on the boundary with regard to the overall shape structure. Conversely, eccentricity transforms (Ecc) can match shapes by signatures of geodesic distance histograms based on information from inside the shape; but they ignore the boundary information. We describe a method that combines the boundary signature of a shape obtained from II and structural information from the Ecc to yield results that improve on them separately. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
35. Evaluation of nitrided titanium separator plates for proton exchange membrane electrolyzer cells.
- Author
-
Toops, Todd J., Brady, Michael P., Zhang, Feng-Yuan, IIIMeyer, Harry M., Ayers, Katherine, Roemer, Andrew, and Dalton, Luke
- Subjects
- *
TITANIUM nitride , *MACHINE separators , *PROTON exchange membrane fuel cells , *ELECTROLYSIS , *THERMAL properties - Abstract
Proton exchanges membrane (PEM) regenerative fuel cell electrolysis of water is of great recent interest as a hydrogen generation technology. Anode side titanium current collectors and separator plates used in these applications typically employ coatings of platinum group metals to achieve durability and performance requirements in the high voltage, oxidizing environment. The present work assessed the potential for lower cost surface modified titanium by both thermal (gas) nitridation and plasma nitridation approaches. The nitrided Ti was found to result in far less hydrogen uptake in coupon testing than did Pt-plated Ti. Short-term (48 h) single-cell performance at 25 °C was approximately 13% better (lower voltage) at 1.2 A cm −2 for thermal and plasma nitrided plates vs. untreated Ti. However, at 50 °C and 1.5 A cm −2 , the thermally nitrided plate exhibited only on the order of 3% better behavior (lower voltage) compared to the untreated Ti and plasma nitrided Ti. Durability testing for 500 h resulted in only a minor degradation in cell performance, on the order of 1–2% voltage increase, with the best behavior exhibited by the thermally nitrided Ti plate. Despite their relatively stable cell performance, extensive local oxidation of the thermally nitrided and plasma nitrided flow field regions was observed. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
36. Can consumers’ willingness to pay incentivize adoption of environmental impact reducing technologies in meat animal production?
- Author
-
White, Robin R. and Brady, Michael
- Subjects
- *
FEED utilization efficiency , *CONSUMERISM , *WILLINGNESS to pay , *BAYESIAN analysis , *CONSUMER attitudes - Abstract
This study develops a model estimating consumer willingness to pay (WTP) for environmental meat attributes and uses a multi-objective nutritional optimizer to explore the extent to which WTP can offset on-farm costs of reducing water use. Data for the WTP model are sourced from a literature survey of the Agricola and Google Scholar databases yielding 46 studies estimating WTP for pure and impure (organic, grass-fed, natural) environmental meat attributes. Bayesian analysis is used to estimate 3 models varying in independent variables. Models are evaluated by the correlation coefficient ( R 2 ), root mean squared error of prediction (RMSPE) and posterior model probability. The most probable model is then used to estimate a confidence range of WTP for pure environmental beef. Impure environmental labels result in higher WTP than pure labels. Non-hypothetical WTP for pure environmental labeling for North American consumers ranges from 6.7% to 32.6%. A case study is conducted to identify the expected reduction in water use that can be funded from capturing WTP through labeling. A multi-objective nutritional optimizer is used to identify ideal management of beef cattle to reduce whole-system water use in three regions of the United States. Cost increases from management are varied over the predicted range in WTP and combined with the probability of a consumer purchasing beef at each WTP value to identify the theoretical effect on expected environmental impact reduction. A 10% premium is the ideal WTP, resulting in water use reductions between 24.4 L and 41.4 L. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
37. Optimizing diet and pasture management to improve sustainability of U.S. beef production.
- Author
-
White, Robin R., Brady, Michael, Capper, Judith L., and Johnson, Kristen A.
- Subjects
- *
DIET , *PASTURE management , *BEEF industry , *INDUSTRIAL management , *SOCIAL acceptance , *WILLINGNESS to pay , *CONSUMER attitudes - Abstract
System sustainability balances environmental impact, economic viability and social acceptability. Assessment methods to investigate impacts of enterprise management and consumer decisions on sustainability of beef cattle operations are critically needed. Tools of this nature are especially important given the predictions of climate variability and the dependence of beef production systems on forage availability. A model optimizing nutritional and pasture management was created to examine the environmental impact of beef production. The model integrated modules calculating cradle-to-farm gate environmental impact, diet cost, pasture growth and willingness to pay (WTP). Least-cost diet and pasture management options served as a baseline to which environmental-impact reducing scenarios were compared. Economic viability was ensured by a constraint limiting change in diet cost to less than consumer WTP. Increased WTP was associated with improved social acceptability. Model outputs were evaluated by comparing to published data. Sensitivity analysis of the WTP constraint was conducted. A series of scenarios then examined how forecasted changes in precipitation patterns might alter forage supply and opportunities to reduce environmental impact in three regions in the United States. On a national scale, single-objective optimization indicated individual reductions in greenhouse gases (GHG), land use and water use of 3.6%, 5.4% and 4.3% were possible by changing diets. Multi-objective optimization demonstrated that GHG, land and water use could be simultaneously reduced by 2.3%. To achieve this change, cow–calf diets relied on grass hay, continuously- or rotationally-grazed irrigated and fertilized pasture as well as rotationally-grazed pasture. Stocker diets used rotationally-grazed, irrigated and fertilized pasture and feedlot diets used grass hay as a forage source. The model was sensitive to consumer WTP. When alternative precipitation patterns were simulated, opportunities to decrease the environmental impact of beef production in the Pacific Northwest and Texas were reduced by precipitation changes; whereas opportunities in the Midwest improved. Economic viability, rather than biological limitations, reduced the potential to improve environmental impact under future precipitation scenarios. Decreased spring rainfall resulted in lower pasture yields and required greater use of stored forages. Related increases in diet cost reduced opportunities to appropriate funds toward investment in environmental-impact reducing pasture management strategies. The model developed in this study is a robust tool that can be used to assess the impacts of enterprise management and consumer decisions on beef production sustainability. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
38. Igniting and Sustaining Interest Among Students Who Have Grown Cold Toward Science.
- Author
-
JACK, BRADY MICHAEL and LIN, HUANN‐SHYANG
- Subjects
- *
SCIENCE education research , *STUDENT attitudes , *TEACHING methods research , *STUDENT interests , *SCIENCE teachers - Abstract
ABSTRACT In the wake of interest-study research in science education over the past 10 years, investigators have published many articles on how to define, measure, and develop students' interest in learning science. This present study approaches empirical investigations on students' interest in learning science from a different perspective. We argue that when three specific instructional strategies are combined, they form the Interest Combustion Triangle (ICT), which ignites and sustains interest in learning science among students who have grown cold toward science content. A future research agenda proposing a newly modified instructional strategy called the K-W-L2-R Strategy Tool for providing science teachers and research investigators with a practical method for operationalizing and testing the ICT within the classroom context is also proposed. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
39. The Dynamics of Partisan Behavior: CPG in the House and in the Districts 1982-2000.
- Author
-
Aldrich, John, Brady, Michael, De Marchi, Scott, McDonald, Ian, Nyhan, Brendan, Rohde, David, and Tofias, Michael
- Subjects
- *
PARTISANSHIP , *LEGISLATIVE bodies , *MATHEMATICAL models ,UNITED States politics & government - Abstract
The article examines the dynamics of U.S. partisan behavior, with focus on the conditional party government (CPG) in the U.S. House of Representatives from 1982 to 2000. CPG links electoral forces and structures to the preferences of the representatives, and links those preferences to party and legislative organizations. A mathematical model, which offers a set of equations that are general to U.S. legislative politics, is presented. The article explores some variables outside the legislature, such as demographics and electoral outcomes.
- Published
- 2006
40. Left versus Rights? Liberal Values, Threat, and Rights Violations.
- Author
-
Brady, Michael, McDonald, Ian, Nyhan, Brendan, and Transue, John
- Subjects
- *
AUTHORITARIANISM , *RIGHT & left (Political science) , *SOCIAL justice , *SOCIAL values - Abstract
The article examines the hypothesis that the American left is motivated by a desire to change government and society according to its vision of social justice. The researchers administered a survey to students in the psychology research pool at a university in the southeastern U.S. They used Altemeyer's definition of authoritarianism to develop their hypothesis. They also measure the values that could predispose a person toward left-wing authoritarianism (LWA) and the threat perception that might activate those values.
- Published
- 2005
41. Comparison of liver iron concentration calculated from R2* at 1.5 T and 3 T.
- Author
-
Pickles, Elisabeth, Kumar, Shravan, Brady, Michael, Telford, Alison, Pavlides, Michael, and Bulte, Daniel
- Subjects
- *
THALASSEMIA diagnosis , *IRON in the body , *PEARSON correlation (Statistics) , *MAGNETIC resonance imaging , *LIVER disease diagnosis - Abstract
Purpose: R2*, a measurement obtained using magnetic resonance imaging (MRI) can be used to estimate liver iron concentration (LIC). 3 T and 1.5 T scanners can be used but conversion of 3 T R2* to LIC is less well validated. In this study the aim was to compare 3 T-R2* LIC and 1.5 T-R2* LIC estimations to assess if they can be used interchangeably. Methods: Thirty participants were scanned at both 1.5 T and 3 T. R2* was measured at both field strengths. 3 T R2* and 1.5 R2* were compared using linear regression and were converted to LIC using different calibration curves. Pearson's rho and Intraclass Correlation Coefficients (ICCs) were used to assess correlation and agreement between 1.5 and 3 T LIC. Bland Altman plots were used to assess bias and limits of agreement. Results: All 1.5 T and 3 T LIC comparisons gave Pearson's rho of 0.99 (p < 0.001). ICC ranged from 0.83 (p = 0.005) to 0.96 (p < 0.001). Biases had magnitude of less than 0.2 mg/g dry weight. Conclusion: Agreement and bias between 3 and 1.5 T-R2* LIC depended on the method used for conversion. There were instances when the agreement was excellent and bias was small, indicating that potentially 3 T-R2* LIC can be used alongside or instead of 1.5 T-R2* LIC but care needs to be taken over the conversion methods selected. Trial registration number: Clinicaltrials.gov NCT03743272, 16 November 2018. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
42. Policy and Systems Change: Planning for Unintended Consequences.
- Author
-
Brady, Michael P., Duffy, Mary Lou, Hazelkorn, Michael, and Bucholz, Jessica L.
- Subjects
- *
EDUCATIONAL change , *EDUCATION policy , *UNITED States education system , *IMPLEMENTATION (Social action programs) , *EDUCATIONAL outcomes , *PUBLIC education reform - Abstract
Planning for policy implementation is as important as the implementation itself. A policy's intent can be subverted by the way the policy is implemented, or when unanticipated outcomes take precedence over the true intent. This article presents three cases of specific instances of unintended outcomes from policy implementation and presents a model to assist educational reformers in minimizing the impact of unintended negative consequences. The article provides policy makers with a means to predict the full array of outcomes—both intended and unintended—when promoting educational reforms that affect the implementation of new practices and policies. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
43. Mesenchymal Stromal Cells Support the Viability and Differentiation of Follicular Lymphoma-Infiltrating Follicular Helper T-Cells.
- Author
-
Brady, Michael T., Hilchey, Shannon P., Hyrien, Ollivier, Spence, Stephen A., and Bernstein, Steven H.
- Subjects
- *
MESENCHYMAL stem cells , *CELL differentiation , *ESTRONE , *T helper cells , *STROMAL cells , *DATA analysis - Abstract
The biology of follicular lymphoma (FL) is largely dictated by the immune-effector and stromal cells that comprise its tumor microenvironment. FL-infiltrating T-cell populations that are thought to be fundamental to FL biology are follicular helper T-cells (TFH), follicular regulatory T-cells (TFR), a recently described population that regulates TFH activity, and regulatory T-cells (Treg). These T-cell populations have dynamic interactions with mesenchymal stromal cells (MSCs) in the tumor microenvironment. Whereas MSCs have been shown to support FL B-cell and Treg viability, their effects on FL-infiltrating TFH and TFR cells have not been described. Herein we show that MSCs support the viability of FL-infiltrating TFH and TFR, as well as Tregs, in part through an IL-6-dependent mechanism. We further demonstrate that MSCs mediate TFH to TFR conversion by inducing the expression of FoxP3 in TFH cells, demonstrating for the first time that human TFR can be derived from TFH cells. Given that the balance of TFH and TFR populations likely dictate, in part, the biology of this disease, our data support the potential for targeting MSCs as a therapeutic strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
44. Down-regulation of signal transducer and activator of transcription 3 improves human acute myeloid leukemia-derived dendritic cell function.
- Author
-
Brady, Michael T., Miller, Austin, Sait, Sheila N., Ford, Laurie A., Minderman, Hans, Wang, Eunice S., Lee, Kelvin P., Baumann, Heinz, and Wetzler, Meir
- Subjects
- *
CELLULAR signal transduction , *GENETIC transcription , *ACUTE myeloid leukemia , *DENDRITIC cells , *CELL differentiation , *T cells - Abstract
Abstract: Signal transducer and activator of transcription (STAT) 3 inhibits dendritic cell (DC) differentiation and is constitutively activated in blasts of approximately half of AML patients. We investigated the correlation between STAT3 activity, DC maturation and the ability to stimulate T-cells in primary acute myeloid leukemia (AML)-derived DCs. STAT3 knock-down by shRNAmir increased the ability of AML-DCs to stimulate T-cells. Treatment of AML-DC with arsenic trioxide, but not AG490, JSI-124 or NSC-74859, led to a more mature phenotype and enhanced T-cell stimulation, while having minimal effect on normal DC. We conclude that AML-DCs have improved immunogenicity after reducing STAT3. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
45. A Modular Strategy for Fully Conjugated Donor–Acceptor Block Copolymers.
- Author
-
Sung-Yu Ku, Brady, Michael A., Treat, Neil D., Cochran, Justin E., Robb, Maxwell J., Kramer, Edward J., Chabinyc, Michael L., and Hawker, Craig J.
- Subjects
- *
ELECTRON donor-acceptor complexes , *BLOCK copolymers , *CHEMICAL synthesis , *CONJUGATED polymers synthesis , *POLYTHIOPHENES , *MOLECULAR self-assembly , *PHOTOVOLTAIC cell design & construction - Abstract
A novel strategy for the synthesis of fully conjugated donor-acceptor block copolymers, in a single reaction step employing Stille coupling polymerization of end-functional polythiophene and AA + BB monomers, is presented. The unique donor-acceptor structure of these block copolymers provides a rich self-assembly behavior, with the first example of a fully conjugated donor-acceptor block copolymer having two separate crystalline domains being obtained. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
46. How THE CONSTITUTIONS OF THE THIRTY-SEVEN STATES IN EFFECT WHEN THE FOURTEENTH AMENDMENT WAS ADOPTED DEMONSTRATE THAT THE GOVERNMENTAL ENDORSEMENT TEST IN ESTABLISHMENT CLAUSE JURISPRUDENCE IS CONTRARY TO AMERICAN HISTORY AND TRADITION.
- Author
-
GETCHELL JR., E. DUNCAN and BRADY, MICHAEL H.
- Subjects
- *
CLAUSES (Law) , *STATE constitutions , *JURISPRUDENCE , *UNITED States history - Abstract
The article discusses issues related to the adoption of Fourteenth Amendment of the U.S constitution in 37 U.S. states. The adoption demonstrated that governmental endorsement test in Establishment Clause jurisprudence is contrary to American history and tradition. It mentions that when the Fourteenth Amendment took effect in state constitutions, nonestablishment principles and values included no concern about governmental endorsement.
- Published
- 2012
47. HIV-related stigma within communities of gay men: a literature review.
- Author
-
Smit, PeterJ., Brady, Michael, Carter, Michael, Fernandes, Ricardo, Lamore, Lance, Meulbroek, Michael, Ohayon, Michel, Platteau, Tom, Rehberg, Peter, Rockstroh, JürgenK., and Thompson, Marc
- Subjects
- *
HIV prevention , *MEDICAL screening , *COMMUNITIES , *DISCRIMINATION (Sociology) , *DRUGS , *GAY people , *HEALTH services accessibility , *PATIENT compliance , *RISK-taking behavior , *SOCIAL isolation , *SOCIAL stigma , *PATIENTS' attitudes ,HIV infections & psychology - Abstract
While stigma associated with HIV infection is well recognised, there is limited information on the impact of HIV-related stigma between men who have sex with men and within communities of gay men. The consequences of HIV-related stigma can be personal and community-wide, including impacts on mood and emotional well-being, prevention, testing behaviour, and mental and general health. This review of the literature reports a growing division between HIV-positive and HIV-negative gay men, and a fragmentation of gay communities based along lines of perceived or actual HIV status. The literature includes multiple references to HIV stigma and discrimination between gay men, men who have sex with men, and among and between many gay communities. This HIV stigma takes diverse forms and can incorporate aspects of social exclusion, ageism, discrimination based on physical appearance and health status, rejection and violence. By compiling the available information on this understudied form of HIV-related discrimination, we hope to better understand and target research and countermeasures aimed at reducing its impact at multiple levels. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
48. Regularising limited view tomography using anatomical reference images and information theoretic similarity metrics
- Author
-
Van de Sompel, Dominique and Brady, Michael
- Subjects
- *
TOMOGRAPHY , *DIAGNOSTIC imaging , *IMAGE reconstruction , *BREAST imaging , *IMAGE registration , *MEDICAL imaging systems - Abstract
Abstract: This paper is concerned with limited view tomography. Inspired by the application of digital breast tomosynthesis (DBT), which is but one of an increasing number of applications of limited view tomography, we concentrate primarily on cases where the angular range is restricted to a narrow wedge of approximately ±30°, and the number of views is restricted to 10–30. The main challenge posed by these conditions is undersampling, also known as the null space problem. As a consequence of the Fourier Slice Theorem, a limited angular range leaves large swathes of the object’s Fourier space unsampled, leaving a large space of possible solutions, reconstructed volumes, for a given set of inputs. We explore the feasibility of using same- or different-modality images as anatomical priors to constrain the null space, hence the solution. To allow for different-modality priors, we choose information theoretic measures to quantify the similarity between reconstructions and their priors. We demonstrate the limitations of two popular choices, namely mutual information and joint entropy, and propose robust alternatives that overcome their limitations. One of these alternatives is essentially a joint mixture model of the image and its prior. Promising mitigation of the data insufficiency problem is demonstrated using 2D synthetic as well as clinical phantoms. This work initially assumes a priori registered priors, and is then extended to allow for the registration to be performed simultaneously with the reconstruction. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
49. Evaluating of Alumina-Forming Austenitic Foil for Advanced Recuperators.
- Author
-
Pint, Bruce A., Brady, Michael P., Yamamoto, Yukinori, Santella, Michael L., Maziasz, Philip J., and Matthews, Wendy J.
- Subjects
- *
AUSTENITIC stainless steel , *HEAT exchangers , *ALUMINUM oxide , *ALLOYS , *OXIDATION , *METAL foils - Abstract
A corrosion- and creep-resistant austenitic stainless steel has been developed for advanced recuperator applications. By optimizing the AI and Cr contents, the alloy is fully austenitic for creep strength while allowing the formation of a chemically stable external alumina scale at temperatures up to 900°C. An alumina scale eliminates long-term problems with the formation of volatile Cr oxy-hydroxides in the presence of water vapor in exhaust gas. As a first step in producing foil for primary surface recuperators, three commercially cast heats have been rolled to ~100 µm thick foil in the laboratory to evaluate performance in creep and oxidation testing. Results from initial creep testing are presented at 675 °C and 750 °C, showing excellent creep strength compared with other candidate foil materials. Laboratory, exposures in humid air at 650-800°C have shown acceptable oxidation resistance. A similar oxidation behavior was observed for sheet specimens of these alloys exposed in a modified 65 kW microturbine for 2871 h. One composition that showed superior creep and oxidation resistance has been selected for the preparation of a commercial batch of foil. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
50. Modeling the effect of water vapor on the interfacial behavior of high-temperature air in contact with Fe20Cr surfaces
- Author
-
Chialvo, Ariel A., Brady, Michael P., Keiser, James R., and Cole, David R.
- Subjects
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HIGH temperatures , *AIR , *OXIDATION , *ADSORPTION (Chemistry) , *SURFACE chemistry , *SIMULATION methods & models , *ATMOSPHERIC water vapor - Abstract
This work uses molecular dynamics simulation to provide an atomistic view of the contrasting interfacial behavior between high-temperature dry air and wet (10–40vol.% water) air in contact with stainless steels. A key finding was that H2O preferentially adsorbs and displaces oxygen at the metal–fluid interface. We also discuss how these findings are consistent with Ehlers et al. proposed competitive adsorption mechanism for the interpretation of the breakaway oxidation, and highlight their impact on other properties. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
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