474 results on '"Brady, Sean F"'
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2. Bacterial cGAS senses a viral RNA to initiate immunity
3. High-throughput retrieval of target sequences from complex clone libraries using CRISPRi
4. Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity
5. Present and future outlooks on environmental DNA-based methods for antibiotic discovery
6. Identification of an Optimized Clinical Development Candidate from Cilagicin, an Antibiotic That Evades Resistance by Dual Polyprenyl Phosphate Binding
7. A naturally inspired antibiotic to target multidrug-resistant pathogens
8. Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens
9. Multiplexed mobilization and expression of biosynthetic gene clusters
10. Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis
11. Unraveling function and diversity of bacterial lectins in the human microbiome
12. Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn‐BNP)‐Coupled Metagenomics
13. Abstract B031: A brain penetrant Nicotinamide-adenine dinucleotide mimetic impedes de novo guanylate synthesis and glioblastoma growth
14. Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity.
15. Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity
16. A Family of Antibiotics That Evades Resistance by Binding Polyprenyl Phosphates
17. Cutting edge culture independent pipeline for detection of novel anti-fungal plant protection compounds in suppressive soils
18. General Strategies for Biosynthetic Gene Cluster Identification, Capture, and Heterologous Expression
19. Overview and Introduction
20. Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale
21. Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity
22. Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens
23. Bacterial cGAS senses a viral RNA to initiate immunity
24. Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences
25. Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
26. High-throughput retrieval of target sequences from complex clone libraries using CRISPRi
27. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist
28. Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
29. Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
30. Discovery of Paenibacillaceae Family Gram-Negative-Active Cationic Lipopeptide Antibiotics Using Evolution-Guided Chemical Synthesis
31. Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
32. eSNaPD: A Versatile, Web-Based Bioinformatics Platform for Surveying and Mining Natural Product Biosynthetic Diversity from Metagenomes
33. Chemical-biogeorgraphic survey of secondary metabolism in soil
34. Culture-independent discovery of natural products from soil metagenomes
35. Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance
36. Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
37. Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
38. Commensal bacteria make GPCR ligands that mimic human signalling molecules
39. Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics
40. Biocatalysts and small molecule products from metagenomic studies
41. Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
42. Cloning and Characterization of New Glycopeptide Gene Clusters Found in an Environmental DNA Megalibrary
43. Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens
44. Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals
45. Metagenome‐Guided Analogue Synthesis Yields Improved Gram‐Negative‐Active Albicidin‐ and Cystobactamid‐Type Antibiotics
46. Multiplexed functional metagenomic analysis of the infant microbiome identifies effectors of NF-κB, autophagy, and cellular redox state
47. Refactoring biosynthetic gene clusters for heterologous production of microbial natural products
48. Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance.
49. Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis
50. Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa
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