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1. Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer

Author

Arends, Christopher Maximilian, Kopp, Klara, Hablesreiter, Raphael, Estrada, Natalia, Christen, Friederike, Moll, Ute Martha, Zeillinger, Robert, Schmitt, Wolfgang Daniel, Sehouli, Jalid, Kulbe, Hagen, Fleischmann, Maximilian, Ray-Coquard, Isabelle, Zeimet, Alain, Raspagliesi, Francesco, Zamagni, Claudio, Vergote, Ignace, Lorusso, Domenica, Concin, Nicole, Bullinger, Lars, Braicu, Elena Ioana, and Damm, Frederik

Published
2024
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2. Correction: Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer

Author

Arends, Christopher Maximilian, Kopp, Klara, Hablesreiter, Raphael, Estrada, Natalia, Christen, Friederike, Moll, Ute Martha, Zeillinger, Robert, Schmitt, Wolfgang Daniel, Sehouli, Jalid, Kulbe, Hagen, Fleischmann, Maximilian, Ray-Coquard, Isabelle, Zeimet, Alain, Raspagliesi, Francesco, Zamagni, Claudio, Vergote, Ignace, Lorusso, Domenica, Concin, Nicole, Bullinger, Lars, Braicu, Elena Ioana, and Damm, Frederik

Published
2024
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3. Tolerability of the niraparib individualized starting dose in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy

Author

Vulsteke, Christof, Chambers, Setsuko K., Pérez, Maria Jesús Rubio, Chan, John K., Raaschou-Jensen, Nicoline, Zhuo, Ying, Lorusso, Domenica, Herzog, Thomas J., de la Motte Rouge, Thibault, Thomes Pepin, Jessica A., Braicu, Elena Ioana, Chen, Lee-may, Levy, Tally, Barter, James F., Pilar Barretina-Ginesta, M., Joosens, Eric, York, Whitney, Malinowska, Izabela A., González-Martín, Antonio, and Monk, Bradley J.

Published
2024
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4. Niraparib Population Pharmacokinetics and Exposure-Response Relationships in Patients With Newly Diagnosed Advanced Ovarian Cancer

Author

Monk, Bradley J., Romero, Ignacio, Graybill, Whitney, Churruca, Cristina, O'Malley, David M., Knudsen, Anja Ør, Yap, Oi Wah Stephanie, Baurain, Jean-François, Rose, Peter G., Denys, Hannelore, Ghamande, Sharad, Pisano, Carmela, Fabbro, Michel, Braicu, Elena Ioana, Calvert, Paula M., Amit, Amnon, Prendergast, Emily, Taylor, Adekemi, Kheibarshekan, Leila, Zhang, Zhi-Yi, Zajic, Stefan, Jewell, Roxanne C., Gupta, Divya, and González-Martín, Antonio

Published
2024
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5. Pazopanib with Topotecan weekly for patients with platinum-resistant or intermediate-sensitive recurrent ovarian cancer: results of a multicentre, open label phase I/II study (TOPAZ)

Author

Chekerov, Radoslav, Arndt, Tjadina, Pietzner, Klaus, Canzler, Ulrich, Wimberger, Pauline, Strauß, Hans-Georg, Mahner, Sven, Woelber, Linn, de Gregorio, Nikolaus, Stocker, Gertraud, von Abel, Ekkehard, Neunhoeffer, Tanja, Belau, Antje Kristina, Mustea, Alexander, Yalinkaya, Isil, Braicu, Elena Ioana, Richter, Rolf, and Sehouli, Jalid

Published
2023
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9. Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial

Author

Abadie-Lacourtoisie, Sophie, Andreetta, Claudia, Anzizar, Nerea, Aoki, Daiseuke, Barretina-Ginesta, Maria-Pilar, Battista, Marco, Bellier, Charlotte, Bentzen, Anne Gry, Berton, Dominique, Billemont, Bertrand, Bjørge, Line, Bjurberg, Maria, Black, Destin, Bologna, Alessandra, Braicu, Elena Ioana, Casanova, Claudia, Chekerov, Radoslav, Chevalier, Annick, Cueva, Juan Fernando, Czogalla, Bastian, Delanoy, Nicolas, Denschlag, Dominik, Derke, Oscar, Eichbaum, Michael, Enomoto, Takayuki, Esteban, Carmen, Fabbro, Michel, Fehm, Tanja, Ferrero, Annamaria, Fleisch, Markus, Floquet, Anne, Frassoldati, Antonio, Gaba, Lydia, Gadducci, Angiolo, García, Yolanda, Geuna, Elena, Guerra, Eva, Hanker, Lars, Hardy-Bessard, Anne-Claire, Harter, Philipp, Hasegawa, Kosei, Hellman, Kristina, Herrero, Ana, Hilpert, Felix, Katsaros, Dionyssios, Koegel, Matthias, Koliadi, Anthoula, Kurtz, Jean-Emmanuel, Lampe, Bjoern, Lissoni, Andrea Alberto, Lortholary, Alain, Mangili, Giorgia, Mansi, Laura, Marmé, Frederik, Mathews, Cara, Mina, William, Minobe, Shinichiro, Moxley, Katherine, Nagao, Shoji, Nicoletto, Ornella, Nishino, Koji, Nishio, Hiroshi, Nishio, Shin, Oaknin, Ana, Onstad, Michaela, Pardo, Beatriz, Pérez-Fidalgo, J Alejandro, Pisano, Carmela, Poveda, Andrés, Radosa, Julia, Randall, Leslie M., Ray-Coquard, Isabelle, Redondo, Andrés, Richardson, Debra, Romero, Ignacio, Ronzino, Graziana, Rubio, Maria Jesús, Selle, Frederic, Takekuma, Munetaka, Takeshima, Nobuhiro, Tasca, Giulia, Tewari, Krishnansu, Todo, Yukiharu, Valabrega, Giorgio, Wimberger, Pauline, Woelber, Linn, Yamaguchi, Satoshi, You, Benoît, Yunokawa, Mayu, Gladieff, Laurence, Martínez-García, Jerónimo, Villacampa, Guillermo, De Giorgi, Ugo, Lindemann, Kristina, Colombo, Nicoletta, Duska, Linda, Leary, Alexandra, Godoy-Ortiz, Ana, Angelergues, Antoine, Fariñas-Madrid, Lorena, Lorusso, Domenica, Manso, Luis, Joly, Florence, Alarcón, Jesús, Follana, Philippe, Lebreton, Coriolan, Dahlstrand, Hanna, D'Hondt, Véronique, and Randall, Leslie M

Published
2024
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10. Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium

Author

Glajzer, Jacek, Castillo-Tong, Dan Cacsire, Richter, Rolf, Vergote, Ignace, Kulbe, Hagen, Vanderstichele, Adriaan, Ruscito, Ilary, Trillsch, Fabian, Mustea, Alexander, Kreuzinger, Caroline, Gourley, Charlie, Gabra, Hani, Taube, Eliane T., Dorigo, Oliver, Horst, David, Keunecke, Carlotta, Baum, Joanna, Angelotti, Timothy, Sehouli, Jalid, and Braicu, Elena Ioana

Published
2023
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11. A randomized phase 2 study of sapanisertib in combination with paclitaxel versus paclitaxel alone in women with advanced, recurrent, or persistent endometrial cancer

Author

Han, Sileny N., Oza, Amit, Colombo, Nicoletta, Oaknin, Ana, Raspagliesi, Francesco, Wenham, Robert M., Braicu, Elena Ioana, Jewell, Andrea, Makker, Vicky, Krell, Jonathan, Alía, Eva María Guerra, Baurain, Jean-François, Su, Zhenqiang, Neuwirth, Rachel, Vincent, Sylvie, Sedarati, Farhad, Faller, Douglas V., and Scambia, Giovanni

Published
2023
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12. LRP1B—a prognostic marker in tubo-ovarian high-grade serous carcinoma

Author

Kolb, Svenja, Hoffmann, Inga, Monjé, Nanna, Dragomir, Mihnea P., Jank, Paul, Bischoff, Philip, Keunecke, Carlotta, Pohl, Jonathan, Kunze, Catarina Alisa, Marchenko, Sofya, Schmitt, Wolfgang D., Kulbe, Hagen, Sers, Christine, Sehouli, Jalid, Braicu, Elena Ioana, Denkert, Carsten, Darb-Esfahani, Silvia, Horst, David, Sinn, Bruno V., and Taube, Eliane T.

Published
2023
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14. Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer

Author

Vanderstichele, Adriaan, Busschaert, Pieter, Landolfo, Chiara, Olbrecht, Siel, Coosemans, An, Froyman, Wouter, Loverix, Liselore, Concin, Nicole, Braicu, Elena Ioana, Wimberger, Pauline, Van Nieuwenhuysen, Els, Han, Sileny N., Van Gorp, Toon, Venken, Tom, Heremans, Ruben, Neven, Patrick, Bourne, Tom, Van Calster, Ben, Timmerman, Dirk, Lambrechts, Diether, and Vergote, Ignace

Published
2022
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15. ASO Visual Abstract: Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome, and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer (HGSOC). A Multicenter, Retrospective Study of the Ovarian Cancer Therapy—Innovative Models Prolong Survival (OCTIPS) Consortium

Author

Glajzer, Jacek, Castillo-Tong, Dan Cacsire, Richter, Rolf, Vergote, Ignace, Kulbe, Hagen, Vanderstichele, Adriaan, Ruscito, Ilary, Trillsch, Fabian, Mustea, Alexander, Kreuzinger, Caroline, Gourley, Charlie, Gabra, Hani, Taube, Eliane T., Dorigo, Oliver, Horst, David, Keunecke, Carlotta, Baum, Joanna, Angelotti, Timothy, Sehouli, Jalid, and Braicu, Elena Ioana

Published
2023
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16. Gene expression markers in peripheral blood and outcome in patients with platinum‐resistant ovarian cancer: A study of the European GANNET53 consortium.

Author

Obermayr, Eva, Mohr, Thomas, Schuster, Eva, Braicu, Elena Ioana, Taube, Eliane, Sehouli, Jalid, Vergote, Ignace, Pujade‐Lauraine, Eric, Ray‐Coquard, Isabelle, Harter, Philipp, Wimberger, Pauline, Joly‐Lobbedez, Florence, Mahner, Sven, Moll, Ute Martha, Concin, Nicole, and Zeillinger, Robert

Subjects
OVARIAN cancer, GENE expression, POLYMERASE chain reaction, DRUG administration, COMBINATION drug therapy
Abstract

Disease progression is a major problem in ovarian cancer. There are very few treatment options for patients with platinum‐resistant ovarian cancer (PROC), and therefore, these patients have a particularly poor prognosis. The aim of the present study was to identify markers for monitoring the response of 123 PROC patients enrolled in the Phase I/II GANNET53 clinical trial, which evaluated the efficacy of Ganetespib in combination with standard chemotherapy versus standard chemotherapy alone. In total, 474 blood samples were collected, comprising baseline samples taken before the first administration of the study drugs and serial samples taken during treatment until further disease progression (PD). After microfluidic enrichment, 27 gene transcripts were analyzed using quantitative polymerase chain reaction and their utility for disease monitoring was evaluated. At baseline, ERCC1 was associated with an increased risk of PD (hazard ratio [HR] 1.75, 95% confidence interval [CI]: 1.20–2.55; p = 0.005), while baseline CDH1 and ESR1 may have a risk‐reducing effect (CDH1 HR 0.66, 95% CI: 0.46–0.96; p = 0.024; ESR1 HR 0.58, 95% CI: 0.39–0.86; p = 0.002). ERCC1 was observed significantly more often (72.7% vs. 53.9%; p = 0.032) and ESR1 significantly less frequently (59.1% vs. 78.3%; p = 0.018) in blood samples taken at radiologically confirmed PD than at controlled disease. At any time during treatment, ERCC1‐presence and ESR1‐absence were associated with short PFS and with higher odds of PD within 6 months (odds ratio 12.77, 95% CI: 4.08–39.97; p < 0.001). Our study demonstrates the clinical relevance of ESR1 and ERCC1 and may encourage the analysis of liquid biopsy samples for the management of PROC patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)‐induced phenotypes for platinum sensitivity and long‐term survival in ovarian cancer—A study from the OVCAD consortium.

Author

Fromhage, Gesa, Obermayr, Eva, Bednarz‐Knoll, Natalia, Van Gorp, Toon, Welsch, Eva, Polterauer, Stephan, Braicu, Elena Ioana, Mahner, Sven, Sehouli, Jalid, Vergote, Ignace, Concin, Nicole, Kurtz, Stefan, Steinbiss, Sascha, Torge, Antje, Zeillinger, Robert, Wölber, Linn, and Brandt, Burkhard

Subjects
EPIDERMAL growth factor receptors, OVARIAN epithelial cancer, OVARIAN cancer, CIRCULATING tumor DNA, RETROTRANSPOSONS, CHROMOSOMES
Abstract

We analyzed variations in the epidermal growth factor receptor (EGFR) gene and 5′‐upstream region to identify potential molecular predictors of treatment response in primary epithelial ovarian cancer. Tumor tissues collected during debulking surgery from the prospective multicenter OVCAD study were investigated. Copy number variations in the human endogenous retrovirus sequence human endogenous retrovirus K9 (HERVK9) and EGFR Exons 7 and 9, as well as repeat length and loss of heterozygosity of polymorphic CA‐SSR I and relative EGFR mRNA expression were determined quantitatively. At least one EGFR variation was observed in 94% of the patients. Among the 30 combinations of variations discovered, enhanced platinum sensitivity (n = 151) was found dominantly with HERVK9 haploidy and Exon 7 tetraploidy, overrepresented among patients with survival ≥120 months (24/29, p =.0212). EGFR overexpression (≥80 percentile) was significantly less likely in the responders (17% vs. 32%, p =.044). Multivariate Cox regression analysis, including age, FIGO stage, and grade, indicated that the patients' subgroup was prognostically significant for CA‐SSR I repeat length <18 CA for both alleles (HR 0.276, 95% confidence interval 0.109–0.655, p =.001). Although EGFR variations occur in ovarian cancer, the mRNA levels remain low compared to other EGFR‐mutated cancers. Notably, the inherited length of the CA‐SSR I repeat, HERVK9 haploidy, and Exon 7 tetraploidy conferred three times higher odds ratio to survive for more than 10 years under therapy. This may add value in guiding therapies if determined during follow‐up in circulating tumor cells or circulating tumor DNA and offers HERVK9 as a potential therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Predictors of long-term progression-free survival in patients with ovarian cancer treated with niraparib in the PRIMA/ENGOT-OV26/GOG-3012 study.

Author

Graybill, Whitney S., Búrdalo, Beatriz Pardo, O'Malley, David M., Vergote, Ignace, Monk, Bradley J., Auranen, Annika, Copeland, Larry J., Sabbatini, Roberto, Herzog, Thomas J., Follana, Philippe, Pothuri, Bhavana, Braicu, Elena Ioana, McCormick, Colleen, Yubero, Alfonso, Moore, Richard G., Vuylsteke, Peter, Raaschou-Jensen, Nicoline, York, Whitney, Hartman, John, and González-Martín, Antonio

Published
2024
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21. Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey

Author

Woopen, Hannah, primary, Keller, Maren, additional, Zocholl, Dario, additional, Mittelstadt, Suzana, additional, Barretina-Ginesta, Maria-Pilar, additional, Heinzelmann-Schwarz, Viola, additional, Lafleur, Judith, additional, Kocián, Roman, additional, Baum, Joanna, additional, Krabisch, Petra, additional, Achimas-Cadariu, Patriciu, additional, Vardar, Mehmet Ali, additional, Vergote, Ignace, additional, Nasser, Sara, additional, Link, Theresa, additional, Gil-Martin, Marta, additional, Zwimpfer, Tibor A., additional, Leitner, Katharina, additional, Jedryka, Marcin, additional, Boxler, Tamara, additional, Braicu, Elena Ioana, additional, and Sehouli, Jalid, additional

Published
2023
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23. PO009/#424 Innovative academic homologous recombination deficiency tests available in advanced ovarian cancer: the European ENGOT initiative

Author

Pujade-Lauraine, Eric, primary, Christinat, Yann, additional, D’Incalci, Maurizio, additional, Schouten, Philip C, additional, Buisson, Adrien, additional, Heukamp, Lukas C, additional, Loverix, Liselore, additional, Callens, Celine, additional, Leman, Raphael, additional, Mckee, Thomas A, additional, Marchini, Sergio, additional, Hahnen, Eric, additional, Saintigny, Pierre, additional, Braicu, Elena Ioana, additional, Gorp, Toon Van, additional, Yaniz-Galende, Elisa, additional, Stern, Marc-Henri, additional, Vaur, Dominique, additional, and Ray-Coquard, Isabelle, additional

Published
2023
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24. #384 First interim analysis of the SCOUT-1 Study (NOGGO Ov54, NCT04830709): a non-interventional study to evaluate treatment patterns and longterm outcome in patients with newly diagnosed advances ovarian cancer

Author

Pietzner, Klaus, primary, Braicu, Elena Ioana, additional, Wimberger, Pauline, additional, Goldmann, Jessika, additional, Kubiak, Karol, additional, Gregorio, Nikolaus De, additional, Radosa, Julia Caroline, additional, Atkas, Bahriye, additional, Ober, Angelika, additional, Brucker, Cosima, additional, Meyer-Wilmes, Philipp, additional, Melekian, Badrig, additional, Sagasser, Jacqueline, additional, Guth, Dagmar, additional, Schnelzer, Andreas, additional, Tchaikovski, Svetlana, additional, Veldink, Hendrik, additional, Lampe, Björn, additional, and Sehouli, Jalid, additional

Published
2023
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27. Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium

Author

Guan, Jun, Darb-Esfahani, Silvia, Richter, Rolf, Taube, Eliane T., Ruscito, Ilary, Mahner, Sven, Woelber, Linn, Prieske, Katharina, Concin, Nicole, Vergote, Ignace, Van Nieuwenhuysen, Els, Achimas-Cadariu, Patriciu, Glajzer, Joanna, Woopen, Hannah, Stanske, Mandy, Kulbe, Hagen, Denkert, Carsten, Sehouli, Jalid, and Braicu, Elena Ioana

Published
2019
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30. Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation

Author

Willing, Eva-Maria, primary, Vollbrecht, Claudia, additional, Vössing, Christine, additional, Weist, Peggy, additional, Schallenberg, Simon, additional, Herbst, Johanna M., additional, Schatz, Stefanie, additional, Jóri, Balázs, additional, Bataillon, Guillaume, additional, Harter, Philipp, additional, Salutari, Vanda, additional, Martin, Antonio Gonzáles, additional, Vergote, Ignace, additional, Colombo, Nicoletta, additional, Roeper, Julia, additional, Berg, Tobias, additional, Berger, Regina, additional, Kah, Bettina, additional, Noettrup, Trine Jakobi, additional, Falk, Markus, additional, Arndt, Kathrin, additional, Polten, Andreas, additional, Ray-Coquard, Isabelle, additional, Selzam, Franziska, additional, Pirngruber, Judith, additional, Schmidt, Stefanie, additional, Hummel, Michael, additional, Tiemann, Markus, additional, Horst, David, additional, Sehouli, Jalid, additional, Pujade-Lauraine, Eric, additional, Tiemann, Katharina, additional, Braicu, Elena Ioana, additional, and Heukamp, Lukas C., additional

Published
2023
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31. ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Author

Su, Ping-ping, primary, Mao, Xiaodan, additional, Ma, Jincheng, additional, Huang, Lixiang, additional, Yu, Lirui, additional, Tang, Shuting, additional, Zhuang, Mingzhi, additional, Lu, Zhonglei, additional, Osafo, Kelvin Stefan, additional, Ren, Yuan, additional, Wang, Xinrui, additional, Lin, Xite, additional, Huang, Leyi, additional, Huang, Xiaoli, additional, Braicu, Elena Ioana, additional, Sehouli, Jalid, additional, and Sun, Pengming, additional

Published
2023
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32. Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial

Author

Oaknin, Ana, Gladieff, Laurence, Martínez-García, Jerónimo, Villacampa, Guillermo, Takekuma, Munetaka, De Giorgi, Ugo, Lindemann, Kristina, Woelber, Linn, Colombo, Nicoletta, Duska, Linda, Leary, Alexandra, Godoy-Ortiz, Ana, Nishio, Shin, Angelergues, Antoine, Rubio, Maria Jesús, Fariñas-Madrid, Lorena, Yamaguchi, Satoshi, Lorusso, Domenica, Ray-Coquard, Isabelle, Manso, Luis, Joly, Florence, Alarcón, Jesús, Follana, Philippe, Romero, Ignacio, Lebreton, Coriolan, Pérez-Fidalgo, J Alejandro, Yunokawa, Mayu, Dahlstrand, Hanna, D'Hondt, Véronique, Randall, Leslie M, Abadie-Lacourtoisie, Sophie, Andreetta, Claudia, Anzizar, Nerea, Aoki, Daiseuke, Barretina-Ginesta, Maria-Pilar, Battista, Marco, Bellier, Charlotte, Bentzen, Anne Gry, Berton, Dominique, Billemont, Bertrand, Bjørge, Line, Bjurberg, Maria, Black, Destin, Bologna, Alessandra, Braicu, Elena Ioana, Casanova, Claudia, Chekerov, Radoslav, Chevalier, Annick, Cueva, Juan Fernando, Czogalla, Bastian, Delanoy, Nicolas, Denschlag, Dominik, Derke, Oscar, Eichbaum, Michael, Enomoto, Takayuki, Esteban, Carmen, Fabbro, Michel, Fehm, Tanja, Ferrero, Annamaria, Fleisch, Markus, Floquet, Anne, Frassoldati, Antonio, Gaba, Lydia, Gadducci, Angiolo, García, Yolanda, Geuna, Elena, Guerra, Eva, Hanker, Lars, Hardy-Bessard, Anne-Claire, Harter, Philipp, Hasegawa, Kosei, Hellman, Kristina, Herrero, Ana, Hilpert, Felix, Katsaros, Dionyssios, Koegel, Matthias, Koliadi, Anthoula, Kurtz, Jean-Emmanuel, Lampe, Bjoern, Lissoni, Andrea Alberto, Lortholary, Alain, Mangili, Giorgia, Mansi, Laura, Marmé, Frederik, Mathews, Cara, Mina, William, Minobe, Shinichiro, Moxley, Katherine, Nagao, Shoji, Nicoletto, Ornella, Nishino, Koji, Nishio, Hiroshi, Nishio, Shin, Oaknin, Ana, Onstad, Michaela, Pardo, Beatriz, Pérez-Fidalgo, J Alejandro, Pisano, Carmela, Poveda, Andrés, Radosa, Julia, Randall, Leslie M., Ray-Coquard, Isabelle, Redondo, Andrés, Richardson, Debra, Romero, Ignacio, Ronzino, Graziana, Rubio, Maria Jesús, Selle, Frederic, Takekuma, Munetaka, Takeshima, Nobuhiro, Tasca, Giulia, Tewari, Krishnansu, Todo, Yukiharu, Valabrega, Giorgio, Wimberger, Pauline, Woelber, Linn, Yamaguchi, Satoshi, You, Benoît, and Yunokawa, Mayu

Abstract

The GOG240 trial established bevacizumab with chemotherapy as standard first-line therapy for metastatic or recurrent cervical cancer. In the BEATcc trial (ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030), we aimed to evaluate the addition of an immune checkpoint inhibitor to this standard backbone.

Published
2024
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33. Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy–Innovative Models Prolong Survival (OCTIPS) Consortium

Author

Ruscito, Ilary, Cacsire Castillo-Tong, Dan, Vergote, Ignace, Ignat, Iulia, Stanske, Mandy, Vanderstichele, Adriaan, Ganapathi, Ram N., Glajzer, Jacek, Kulbe, Hagen, Trillsch, Fabian, Mustea, Alexander, Kreuzinger, Caroline, Benedetti Panici, Pierluigi, Gourley, Charlie, Gabra, Hani, Kessler, Mirjana, Sehouli, Jalid, Darb-Esfahani, Silvia, and Braicu, Elena Ioana

Published
2017
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34. Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).

Author

Ruscito, Ilary, Cacsire Castillo-Tong, Dan, Vergote, Ignace, Ignat, Iulia, Stanske, Mandy, Vanderstichele, Adriaan, Glajzer, Jacek, Kulbe, Hagen, Trillsch, Fabian, Mustea, Alexander, Kreuzinger, Caroline, Benedetti Panici, Pierluigi, Gourley, Charlie, Gabra, Hani, Nuti, Marianna, Taube, Eliane T., Kessler, Mirjana, Sehouli, Jalid, Darb-Esfahani, Silvia, and Braicu, Elena Ioana

Published
2018
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35. Supplementary figure legends and the title and notes of supplementary tables from A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

Author

Kreuzinger, Caroline, primary, Geroldinger, Angelika, primary, Smeets, Dominiek, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Koller, Julia, primary, Wolf, Andrea, primary, Darb-Esfahani, Silvia, primary, Joehrens, Korinna, primary, Vergote, Ignace, primary, Vanderstichele, Adriaan, primary, Boeckx, Bram, primary, Lambrechts, Diether, primary, Gabra, Hani, primary, Wisman, G. Bea A., primary, Trillsch, Fabian, primary, Heinze, Georg, primary, Horvat, Reinhard, primary, Polterauer, Stephan, primary, Berns, Els, primary, Theillet, Charles, primary, and Cacsire Castillo-Tong, Dan, primary

Published
2023
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36. Supplementary Figure S4 from A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

Author

Kreuzinger, Caroline, primary, Geroldinger, Angelika, primary, Smeets, Dominiek, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Koller, Julia, primary, Wolf, Andrea, primary, Darb-Esfahani, Silvia, primary, Joehrens, Korinna, primary, Vergote, Ignace, primary, Vanderstichele, Adriaan, primary, Boeckx, Bram, primary, Lambrechts, Diether, primary, Gabra, Hani, primary, Wisman, G. Bea A., primary, Trillsch, Fabian, primary, Heinze, Georg, primary, Horvat, Reinhard, primary, Polterauer, Stephan, primary, Berns, Els, primary, Theillet, Charles, primary, and Cacsire Castillo-Tong, Dan, primary

Published
2023
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37. Supplementary Table 1 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Author

Flanagan, James M., primary, Wilson, Angela, primary, Koo, Chail, primary, Masrour, Nahal, primary, Gallon, John, primary, Loomis, Erick, primary, Flower, Kirsty, primary, Wilhelm-Benartzi, Charlotte, primary, Hergovich, Alexander, primary, Cunnea, Paula, primary, Gabra, Hani, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Darb-Esfahani, Silvia, primary, Vanderstichele, Adriaan, primary, Vergote, Ignace, primary, Kreuzinger, Caroline, primary, Castillo-Tong, Dan Cacsire, primary, Wisman, G. Bea A., primary, Berns, Els MJJ, primary, Siddiqui, Nadeem, primary, Paul, James, primary, and Brown, Robert, primary

Published
2023
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38. Supplementary Table S2 from A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

Author

Kreuzinger, Caroline, primary, Geroldinger, Angelika, primary, Smeets, Dominiek, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Koller, Julia, primary, Wolf, Andrea, primary, Darb-Esfahani, Silvia, primary, Joehrens, Korinna, primary, Vergote, Ignace, primary, Vanderstichele, Adriaan, primary, Boeckx, Bram, primary, Lambrechts, Diether, primary, Gabra, Hani, primary, Wisman, G. Bea A., primary, Trillsch, Fabian, primary, Heinze, Georg, primary, Horvat, Reinhard, primary, Polterauer, Stephan, primary, Berns, Els, primary, Theillet, Charles, primary, and Cacsire Castillo-Tong, Dan, primary

Published
2023
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39. Supplementary Table 4 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Author

Flanagan, James M., primary, Wilson, Angela, primary, Koo, Chail, primary, Masrour, Nahal, primary, Gallon, John, primary, Loomis, Erick, primary, Flower, Kirsty, primary, Wilhelm-Benartzi, Charlotte, primary, Hergovich, Alexander, primary, Cunnea, Paula, primary, Gabra, Hani, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Darb-Esfahani, Silvia, primary, Vanderstichele, Adriaan, primary, Vergote, Ignace, primary, Kreuzinger, Caroline, primary, Castillo-Tong, Dan Cacsire, primary, Wisman, G. Bea A., primary, Berns, Els MJJ, primary, Siddiqui, Nadeem, primary, Paul, James, primary, and Brown, Robert, primary

Published
2023
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40. Supplementary information from Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses

Author

Vanderstichele, Adriaan, primary, Busschaert, Pieter, primary, Smeets, Dominiek, primary, Landolfo, Chiara, primary, Van Nieuwenhuysen, Els, primary, Leunen, Karin, primary, Neven, Patrick, primary, Amant, Frédéric, primary, Mahner, Sven, primary, Braicu, Elena Ioana, primary, Zeilinger, Robert, primary, Coosemans, An, primary, Timmerman, Dirk, primary, Lambrechts, Diether, primary, and Vergote, Ignace, primary

Published
2023
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41. Supplementary Table 2 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Author

Flanagan, James M., primary, Wilson, Angela, primary, Koo, Chail, primary, Masrour, Nahal, primary, Gallon, John, primary, Loomis, Erick, primary, Flower, Kirsty, primary, Wilhelm-Benartzi, Charlotte, primary, Hergovich, Alexander, primary, Cunnea, Paula, primary, Gabra, Hani, primary, Braicu, Elena Ioana, primary, Sehouli, Jalid, primary, Darb-Esfahani, Silvia, primary, Vanderstichele, Adriaan, primary, Vergote, Ignace, primary, Kreuzinger, Caroline, primary, Castillo-Tong, Dan Cacsire, primary, Wisman, G. Bea A., primary, Berns, Els MJJ, primary, Siddiqui, Nadeem, primary, Paul, James, primary, and Brown, Robert, primary

Published
2023
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42. Supplementary Figures and Tables from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
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43. Supplementary Table S2 from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
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44. Supplementary Figure Legends from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
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45. Supplementary Methods from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
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46. Current Treatment Practices and Prognostic Factors in Early-Stage Ovarian Cancer—An Analysis of the NOGGO/JAGO

Author

Heublein, Sabine, primary, Baum, Joanna, additional, Jaeger, Anna, additional, Grimm-Glang, Donata, additional, Olthoff, Julia, additional, Braicu, Elena Ioana, additional, Azzam Nieto, Osama, additional, Hassdenteufel, Kathrin, additional, Schmalfeldt, Barbara, additional, Hanker, Lars, additional, Wallwiener, Markus, additional, Schneeweiss, Andreas, additional, Sehouli, Jalid, additional, and Pietzner, Klaus, additional

Published
2023
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49. TP034/#1534 Randomized phase III trial on niraparib-TSR-042 (Dostarlimab) versus physician’s choice chemotherapy in recurrent ovarian, fallopian tube, primary peritoneal cancer platinum resistant patients: nitche trial(MITO 33)

Author

Salutari, Vanda, primary, Musacchio, Lucia, additional, Pignata, Sandro, additional, Braicu, Elena Ioana, additional, Cibula, David, additional, Colombo, Nicoletta, additional, Frenel, Jean-Sébastien, additional, Zagouri, Flora, additional, Camarda, Floriana, additional, Giolitto, Serena, additional, Giudice, Elena, additional, Perri, Maria Teresa, additional, Scambia, Giovanni, additional, and Lorusso, Domenica, additional

Published
2022
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50. TP038/#1408 Rucaparib maintenance after bevacizumab maintenance following carboplatin based first line chemotherapy in ovarian cancer

Author

Dysarz, Jessica, primary, Braicu, Elena Ioana, additional, Pietzner, Klaus, additional, Zocholl, Dario, additional, Rogmans, Gunther, additional, Wimberger, Pauline, additional, Egger, Eva-Katharina, additional, Gerber, Jens, additional, Eichbaum, Michael, additional, Heitz, Florian, additional, Kupec, Tomás, additional, Koch, Martin, additional, Deryal, Mustafa, additional, Witteler, Ralf, additional, Sperfeld, Antje, additional, Tomé, Oliver, additional, Schmalfeldt, Barbara, additional, Marmé, Frederik, additional, Czogalla, Bastian, additional, and Sehouli, Jalid, additional

Published
2022
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