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7. The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis

Author

Vogel, Bob O., Lett, Tristram A., Erk, Susanne, Mohnke, Sebastian, Wackerhagen, Carolin, Brandl, Eva J., Romanczuk-Seiferth, Nina, Otto, Kristina, Schweiger, Janina I., Tost, Heike, Nöthen, Markus M., Rietschel, Marcella, Degenhardt, Franziska, Witt, Stephanie H., Meyer-Lindenberg, Andreas, Heinz, Andreas, and Walter, Henrik

Published
2018
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16. Trail Making Test Error Analysis in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Dementia With and Without Depression.

Author

Hafiz, Nicklas J, Lohse, Andrea, Haas, Rico, Reiche, Simon, Sedlaczek, Lara, Brandl, Eva J, and Riemer, Thomas G

Subjects
ALZHEIMER'S disease, MILD cognitive impairment, WISCONSIN Card Sorting Test, COGNITION disorders, TRAIL Making Test, COGNITIVE analysis, MENTAL depression
Abstract

Objective Standard evaluation of the Trail Making Test (TMT) only incorporates completion times. However, the analysis of different error types may provide more insight into underlying cognitive processes and could also increase diagnostic accuracy. This cross-sectional observational study compared three different TMT error types and assessed their diagnostic utility in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's dementia (AD) with or without depression. Method We evaluated 618 outpatients of a memory clinic with SCD (N  = 190), MCI (N  = 210), or AD (N  = 218). Of these, 157 had comorbid depression. TMT completion times, total error rates, and the three error types "sequencing error," "perseverative error," and "proximity error" were examined. Results Results indicated that patients with MCI or AD committed more errors on TMT B, and specifically more perseverative errors than patients with SCD (p  < 0.001). Depression was not associated with any TMT error type. Including TMT errors in models predicting diagnosis group by TMT completion times did not increase predictive accuracy, measured by areas under the curve. Conclusions The findings do not indicate any impact of comorbid depression on TMT errors. Moreover, TMT error analysis does not seem to provide additional diagnostic utility for SCD, MCI, and AD diagnoses. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

Author

Pouget, Jennie G, Gonçalves, Vanessa F, Nurmi, Erika L, Laughlin, Christopher P, Mallya, Karyn S, McCracken, James T, Aman, Michael G, McDougle, Christopher J, Scahill, Lawrence, Misener, Virginia L, Tiwari, Arun K, Zai, Clement C, Brandl, Eva J, Felsky, Daniel, Leung, Amy Q, Lieberman, Jeffrey A, Meltzer, Herbert Y, Potkin, Steven G, Niedling, Charlotte, Steimer, Werner, Leucht, Stefan, Knight, Jo, Müller, Daniel J, and Kennedy, James L

Published
2015
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18. The Differential Impact of Lockdown Measures Upon Migrant and Female Psychiatric Patients – A Cross-Sectional Survey in a Psychiatric Hospital in Berlin, Germany

Author

Moran, James K., Bretz, Joachim, Winkler, Johanna, Gutwinski, Stefan, Brandl, Eva J., and Schouler-Ocak, Meryam

Subjects
Psychiatry, lockdown measures, cultural psychiatry, RC435-571, migrant psychiatric patient, COVID-19, survey, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research
Abstract

The COVID-19 pandemic could have major effects on already vulnerable individuals with psychiatric disorders. It is important to assess how different patient groups respond to stress related to the pandemic, and what additional factors influence it, including family-related stress, migration background, and sex. We conducted a survey in a sample of 294 psychiatric patients in a large outpatient clinic in Berlin, measuring level of distress in relation to COVID-19 lockdown as well as family-related distress. We also measured potential influencing factors such as media consumption and medical support. In the migration background group, we found that women had more lockdown related psychological distress than men. This was not apparent in those patients with a German background. We found that females were more strongly affected by family-related distress, particularly those with a migration background. People with PTSD were most strongly affected by family-related distress, whereas people with psychotic disorders and addiction reported the least distress. There were no effects of media consumption. There were no differences in ability to abide by the lockdown related restrictions across diagnoses. Our results support earlier findings on differential vulnerability of diagnostic groups to these stressors. Thus, clinicians can optimize treatment by taking family-related stressors into account particularly for females and people with a migrant background.

Published
2021
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22. Alcohol and Dementia – What is the Link? A Systematic Review

Author

Wiegmann,Caspar, Mick,Inge, Brandl,Eva J., Heinz,Andreas, and Gutwinski,Stefan

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Caspar Wiegmann, 1 Inge Mick, 1 Eva J Brandl, 1 Andreas Heinz, 1, 2 Stefan Gutwinski 1 1Department of Psychiatry and Psychotherapy, Psychiatric Hospital of Charité at St. Hedwig Hospital, Berlin, Germany; 2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Berlin, GermanyCorrespondence: Caspar WiegmannPsychiatrische Universitätsklinik der Charité im St. Hedwig-Krankenhaus, Große Hamburger Str. 5-11, Berlin-Mitte 10115, GermanyTel +49 30 2311 2500Email caspar.wiegmann@charite.deBackground: Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light to moderate alcohol consumption, there is no persuasive model of an underlying biochemical mechanism. The purpose of this article is to review current models on alcohol neurotoxicity and dementia and to analyze and compare studies focusing on the epidemiological link between alcohol consumption and the risk of dementia.Methods: The electronic database Pubmed was searched for studies published between 1994 and 2019 concerning the topic.Results: Available epidemiological studies are not sufficient to verify a protective effect of alcohol on dementia development.Keywords: alcohol neurotoxicity, Alzheimer’s disease, vascular dementia, Korsakoff´s syndrome

Published
2020

23. Additional file 1 of Attitudes towards psychopharmacology and psychotherapy in psychiatric patients with and without migration background

Author

Brandl, Eva J., Dietrich, Nora, Mell, Nicoleta, Winkler, Johanna G., Gutwinski, Stefan, H. Joachim Bretz, and Meryam Schouler-Ocak

Abstract

Additional file 1: Supplementary Tables. Tables S1–5 Results and descriptive statistics of the two analysis of covariance with the factor migration background and the Drug Attitude Inventory (DAI) as dependent variable. R2 = .19*, corrected R2 = .17 (both for analysis 2). The corrections are based on the mean value of SCL Somatization M = 2.41, SCL Depression M = 2.83, SCL Anxiety M = 1.99. The DAI value represents an arithmetic mean of a 2 point Likert scale (1 = True, 2 = False) with higher values indicating a more positive attitude. MENA = Middle East and North Africa Region, MG = migration background, DAI = Drug Attitude Inventory, SCL = Symptom Check List, SE = standard error, Sum Sq = Sum of Squares, df = degrees of freedom, MSS = Mean sum of squares. Table S6. Complete results of the hierarchical Regression predicting the QUAPT scales judgment, competence, acceptance and general attitude as well as the DAI scale within the samples with Turkish, East European and MENAP background. The acculturation scales are added in the second step. School education: 0 = low, 1 = high, Gender: 0 = female, 1 = male, religious affiliation: 0 = yes, 1 = no. Higher scores on the scales of the QUAPT and DAI indicate a more positive attitude on that scale. For simplicity reasons the control variables are only presented in step 1. MENA = Middle East and North Africa Region, QUAPT = Questionnaire on Attitudes Toward Psychotherapeutic Treatment, DAI = Drug Attitude Inventory, SCL = Symptom Check List.* p

Published
2020
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29. F51. Putative Causal Relationship Among Polygenic Scores, Cortical Surfaces, and General Intelligence

Author

Lett, Tristram, primary, Vogel, Bob, additional, Ripke, Stephan, additional, Wackerhagen, Carolin, additional, Erk, Susanne, additional, Brandl, Eva J., additional, Nöthen, Markus, additional, Rietschel, Marcella, additional, Degenhardt, Franziska, additional, Romanczuk-Seiferth, Nina, additional, Witt, Stephanie, additional, Banaschewski, Tobias, additional, Barker, Gareth, additional, Bokde, Arun, additional, Bromberg, Uli, additional, Büchel, Christian, additional, Quinlan, Erin Burke, additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Grigis, Antoine, additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Paillere Martinot, Marie-Laure, additional, Artiges, Eric, additional, Lemaitre, Herve, additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Paus, Tomas, additional, Poustka, Luise, additional, Fröhner, Juliane, additional, Smolka, Michael, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Tost, Heike, additional, Meyer-Lindenberg, Andreas, additional, Heinz, Andreas, additional, and Walter, Henrik, additional

Published
2019
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32. Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence.

Author

Lett, Tristram A, Vogel, Bob O, Ripke, Stephan, Wackerhagen, Carolin, Erk, Susanne, Awasthi, Swapnil, Trubetskoy, Vassily, Brandl, Eva J, Mohnke, Sebastian, Veer, Ilya M, Nöthen, Markus M, Rietschel, Marcella, Degenhardt, Franziska, Romanczuk-Seiferth, Nina, Witt, Stephanie H, Banaschewski, Tobias, Bokde, Arun L W, Büchel, Christian, Quinlan, Erin B, and Desrivières, Sylvane

Published
2020
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34. Cortical surface‐based threshold‐free cluster enhancement and cortexwise mediation

Author

Lett, Tristram A., primary, Waller, Lea, additional, Tost, Heike, additional, Veer, Ilya M., additional, Nazeri, Arash, additional, Erk, Susanne, additional, Brandl, Eva J., additional, Charlet, Katrin, additional, Beck, Anne, additional, Vollstädt‐Klein, Sabine, additional, Jorde, Anne, additional, Kiefer, Falk, additional, Heinz, Andreas, additional, Meyer‐Lindenberg, Andreas, additional, Chakravarty, M. Mallar, additional, and Walter, Henrik, additional

Published
2017
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35. Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain

Author

Tiwari, Arun K., primary, Zhang, Danning, additional, Pouget, Jennie G., additional, Zai, Clement C., additional, Chowdhury, Nabilah I., additional, Brandl, Eva J., additional, Qin, Li, additional, Freeman, Natalie, additional, Lieberman, Jeffrey A., additional, Meltzer, Herbert Y., additional, Kennedy, James L., additional, and Müller, Daniel J., additional

Published
2016
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39. Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

Author

Pouget, Jennie G., Gonçalves, Vanessa F., Nurmi, Erika L., Laughlin, Christopher P., Mallya, Karyn S., McCracken, James T., Aman, Michael G., McDougle, Christopher J., Scahill, Lawrence, Misener, Virginia L., Tiwari, Arun K., Zai, Clement C., Brandl, Eva J., Felsky, Daniel, Leung, Amy Q., Lieberman, Jeffrey A., Meltzer, Herbert Y., Potkin, Steven G., Niedling, Charlotte, Steimer, Werner, Leucht, Stefan, Knight, Jo, Müller, Daniel J., Kennedy, James L., Pouget, Jennie G., Gonçalves, Vanessa F., Nurmi, Erika L., Laughlin, Christopher P., Mallya, Karyn S., McCracken, James T., Aman, Michael G., McDougle, Christopher J., Scahill, Lawrence, Misener, Virginia L., Tiwari, Arun K., Zai, Clement C., Brandl, Eva J., Felsky, Daniel, Leung, Amy Q., Lieberman, Jeffrey A., Meltzer, Herbert Y., Potkin, Steven G., Niedling, Charlotte, Steimer, Werner, Leucht, Stefan, Knight, Jo, Müller, Daniel J., and Kennedy, James L.

Abstract

AIM: TSPO is a neuroinflammatory biomarker and emerging therapeutic target in psychiatric disorders. We evaluated whether TSPO polymorphisms contribute to interindividual variability in schizophrenia, antipsychotic efficacy and antipsychotic-induced weight gain. PATIENTS & METHODS: We analyzed TSPO polymorphisms in 670 schizophrenia cases and 775 healthy controls. Gene-gene interactions between TSPO and other mitochondrial membrane protein-encoding genes (VDAC1 and ANT1) were explored. Positive findings were evaluated in two independent samples (Munich, n = 300; RUPP, n = 119). RESULTS: TSPO rs6971 was independently associated with antipsychotic-induced weight gain in the discovery (puncor = 0.04) and RUPP samples (p = 3.00 × 10(-3)), and interacted with ANT1 rs10024068 in the discovery (p = 1.15 × 10(-3)) and RUPP samples (p = 2.76 × 10(-4)). CONCLUSION: Our findings highlight TSPO as a candidate for future investigations of antipsychotic-induced weight gain, and support the involvement of mitochondrial membrane components in this serious treatment side effect.

Published
2015

40. Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

Author

Tiwari, Arun K., Zhang, Danning, Pouget, Jennie G., Zai, Clement C., Chowdhury, Nabilah I., Brandl, Eva J., Qin, Li, Freeman, Natalie, Lieberman, Jeffrey A., Meltzer, Herbert Y., Kennedy, James L., and Müller, Daniel J.

Subjects
ANTIPSYCHOTIC agents, SCHIZOPHRENIA, PATHOLOGICAL psychology, PEOPLE with schizophrenia, OLANZAPINE
Abstract

Objectives: A positive correlation between antipsychotic-induced weight gain (AIWG) and the antagonist effect of antipsychotic drugs at the histamine H1 receptor (HRH1) as well as the agonist effect at the histamine H3 receptor (HRH3) in the brain has been consistently demonstrated. We investigated the potential impact of single-nucleotide polymorphisms (SNPs) in HRH1 and HRH3 genes on AIWG. Methods: We analysed 40 tagSNPs in HRH1 (n = 34) and HRH3 (n = 6) in schizophrenia/schizoaffective disorder patients (n = 193) primarily treated with clozapine or olanzapine for up to 14 weeks. Linear regression was used to evaluate the association between SNPs and AIWG, with baseline weight and treatment duration as covariates. Results: In HRH1, a nominal association of rs7639145 with AIWG was observed in patients of European ancestry treated with either clozapine or olanzapine (P = 0.043; β = 1.658; n = 77). We observed nominal association for two HRH1 SNPs rs346074 (P = 0.002; β = -5.024) and rs13064530 (P = 0.004; β = -5.158) in patients of African ancestry treated with either clozapine or olanzapine (n = 37). However, the above associations are not significant after correcting for multiple testing. In HRH3, we did not observe association in either ancestry. Conclusions: The current study suggests that SNPs in HRH1 and HRH3 may not have a major role in AIWG. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain.

Author

Zai, Clement C., Tiwari, arun K., Chowdhury, Nabilah I., Brandl, Eva J., Shaikh, Sajid a., Freeman, Natalie, Lieberman, Jeffrey a., Meltzer, Herbert Y., Kennedy, James L., and Müller, Daniel J.

Subjects
WEIGHT gain risk factors, SEROTONIN receptors, SIDE effects of antipsychotic drugs, SCHIZOPHRENIA treatment, WEIGHT gain, SINGLE nucleotide polymorphisms
Abstract

Background: Schizophrenia (SCZ) is a chronic severe neuropsychiatric disorder, where pharmacological treatment has been hindered by adverse effects, including antipsychoticinduced weight gain (AIWG) and related complications. Genetic studies have been exploring the appetite regulation and energy homeostasis pathways in AIWG with some promising leads. The serotonin system has been shown to participate in these pathways. Methods: In the current study, we examined single nucleotide polymorphisms across the serotonin receptor genes HTR3A and HTR3B. Prospective weight change was assessed for a total of 149 SCZ patients of European ancestry. Results: We did not find the tested HTR3A or HTR3B gene markers to be associated with AIWG in our sample. Conclusion: Our preliminary findings suggest that these receptors may not play a major role in predicting AIWG. [ABSTRACT FROM AUTHOR]

Published
2017
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