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8 results on '"Brar, Herb"'

2. Cell-Free DNA Analysis for Noninvasive Examination of Trisomy

Author

Norton, Mary E, Jacobsson, Bo, Swamy, Geeta K, Laurent, Louise C, Ranzini, Angela C, Brar, Herb, Tomlinson, Mark W, Pereira, Leonardo, Spitz, Jean L, Hollemon, Desiree, Cuckle, Howard, Musci, Thomas J, and Wapner, Ronald J

Subjects
Genetics, Genetic Testing, Prevention, Pediatric, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Published
2015

6. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18

Author

Norton, Mary E., Brar, Herb, Weiss, Jonathan, Karimi, Ardeshir, Laurent, Louise C., Caughey, Aaron B., Rodriguez, Hellen M., Williams, John, III, Mitchell, Michael E., Adair, Charles D., Lee, Hanmin, Jacobsson, Bo, Tomlinson, Mark W., Oepkes, Dick, Hollemon, Desiree, Sparks, Andrew B., Oliphant, Arnold, and Song, Ken

Published
2012
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8. The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy.

Author

Brar H, Wang E, Struble C, Musci TJ, and Norton ME

Subjects
Adolescent, Adult, Female, Humans, Middle Aged, Pregnancy, Risk Factors, Young Adult, DNA blood, Maternal Age, Nuchal Translucency Measurement, Trisomy diagnosis
Abstract

Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood., Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement., Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction., Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.

Published
2013
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