Author: "Brasca, M. Gabriella" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Brasca, M. Gabriella"' showing total 2 results

Start Over Author "Brasca, M. Gabriella"

Author: D’Alessio, Roberto, primary, Bargiotti, Alberto, additional, Metz, Suzanne, additional, Brasca, M. Gabriella, additional, Cameron, Alexander, additional, Ermoli, Antonella, additional, Marsiglio, Aurelio, additional, Polucci, Paolo, additional, Roletto, Fulvia, additional, Tibolla, Marcellino, additional, Vazquez, Michael L., additional, Vulpetti, Anna, additional, and Pevarello, Paolo, additional
Published: 2005
Full Text: View/download PDF

Author: D'Alessio R, Bargiotti A, Metz S, Brasca MG, Cameron A, Ermoli A, Marsiglio A, Polucci P, Roletto F, Tibolla M, Vazquez ML, Vulpetti A, and Pevarello P
Subjects: Cell Line, Tumor, Cell Proliferation drug effects, Crystallization, Crystallography, X-Ray, Cyclin A antagonists & inhibitors, Cyclin-Dependent Kinase 2, Enzyme Inhibitors chemical synthesis, Glycogen Synthase Kinase 3 antagonists & inhibitors, Humans, Models, Molecular, Molecular Structure, Pyrazoles chemical synthesis, Structure-Activity Relationship, CDC2-CDC28 Kinases antagonists & inhibitors, Enzyme Inhibitors classification, Enzyme Inhibitors pharmacology, Pyrazoles classification, Pyrazoles pharmacology
Abstract: The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.
Published: 2005
Full Text: View/download PDF

Books, media, physical & digital resources

Searchworks