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195 results on '"Brault, V."'

2. Estimating the number of change-points in a two-dimensional segmentation model without penalization

Author

Brault, V., Delattre, M., Lebarbier, E., Mary-Huard, T., and Lévy-Leduc, C.

Subjects
Mathematics - Statistics Theory
Abstract

In computational biology, numerous recent studies have been dedicated to the analysis of the chromatin structure within the cell by two-dimensional segmentation methods. Motivated by this application, we consider the problem of retrieving the diagonal blocks in a matrix of observations. The theoretical properties of the least-squares estimators of both the boundaries and the number of blocks proposed by L\'evy-Leduc et al. [2014] are investigated. More precisely, the contribution of the paper is to establish the consistency of these estimators. A surprising consequence of our results is that, contrary to the onedimensional case, a penalty is not needed for retrieving the true number of diagonal blocks. Finally, the results are illustrated on synthetic data., Comment: 30 pages, 8 figures

Published
2015

4. Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome

Author

Brault, V., Besson, V., Magnol, L., Duchon, A., Hérault, Y., Starke, K., editor, Born, G. V. R., editor, Duckles, S., editor, Eichelbaum, M., editor, Ganten, D., editor, Hofmann, F., editor, Rosenthal, W., editor, Rubanyi, G., editor, Feil, Robert, editor, and Metzger, Daniel, editor

Published
2007
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8. Abstracts of presentations on plant protection issues at the xth international congress of virology: August 11–16, 1996 Binyanei haOoma, Jerusalem Iarael part 3(final part)

Author

Liu, Sijun, Bedford, Ian D., Markham, Peter G., Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J. F. J. M., Taiwo, M. A., Dijkstra, J., Martinez, B., López-Moya, J. J., Llave, C., Díaz-Ruíz, J. R., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., López-Moya, J. J., Pirone, T. P., Visser, Peter B., Bol, John F., Hernández, Carmen, Brown, Derek J. F., Pappu, H. R., Culbreath, A. K., Todd, J. W., McPherson, R. M., Sherwood, J. L., Bertrand, P. F., Robbins, M. A., Reade, R. D., Rochon, D. M., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D. -E., Vetten, H. J., Manqussopoulos, I. N., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef J., Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I. B., Qu, Feng, Morris, T. Jack, Steinkellner, H., Puehringer, H., Machado, A. M. Laimer da Câmara, Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J. P., Bó, E. Dal, Torre, M. E. Sánchez de la, Djelouah, K., García, M. L., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y. G., Randles, J. W., Samson, A. C. R., Wilford, J. N., Chapman, S., Santa Cruz, S., Wilson, T. M. A., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B. K., Possee, R. D., French, T. J., Finkelstein, Y., Levi, B. Z., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Qi, Yipeng, Huang, Yongxiu, Lu, Liquan, Du, Quansheng, Watson, S. K., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E. A. van, Vlak, J. M., Heldens, J. G. M., Chejanovsky, N., Gershburg, E., Toister-Achituv, Mira, Faruchi, S., Kamensky, B., Faktor, O., Faktor, O., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Chejanovsky, N., Zilberberg, N., Gershburg, E., Stockholm, D., Rivkin, H., Chejanovsky, N., Gurevitz, M., Zilberberg, N., Gershburg, E., Smith, P., King, L. A., Bamett, A., Windass, J. D., Possee, R. D., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L. A., Jarvis, D. L., Reilly, L., Hoover, K., Schultz, C. M., Hammock, B. D., Gordon, K. H. J., Bawden, A. L., Brooks, E. M., Lincoln, M. R., Hanzlik, T. N., Larkin, P. J., Gordon, K. H. J., Bawden, A. L., van Hulten, M. C. W., Hanzlik, T. N., Hendry, D. A., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Possee, Robert, King, Linda, Phanis, Constantinos, O’Reilly, David R., Clarke, E., Tristem, Michael, Cory, Jennifer, O’Reilly, David R., Mayo, M. A., Duncan, G. H., Reavy, B., Gildow, F. E., Lamb, J. W., Hay, R. T., Li, Shoudong, Qi, Bing, Wang, Jiawang, Qi, Yipeng, O’Reilly, David R., Kang, WonKyung, Crook, Norman E., Winstanley, Doreen, Alaoui-Ismaili, M. H., Richardson, C. D., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D. L., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan Antonio, Wang, S., Miller, W. A., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas M., Hull, Roger, Hohn, Thomas, Hefferon, K. L., AbouHaider, M. G., Hulanicka, D., Juszczuk, M., Iskakov, B. K., Shmanov, M. A., Polimbetova, N. S., Zhanybekova, S. Sh., Lee, A. V., Galiakparov, N. N., Dale, J. L., Beetham, P. R., Hafner, G. J., Harding, R. M., and Dale, J. L.

Published
1998
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10. Interactions trophiques médiées par des virus entre les pucerons et leurs ennemis naturels

Author

Dupont, C., Michiels, A., Sochard, Corentin, Dardenne, N., Meyer, S., Brault, V., Outreman, Yannick, Sentis, A., Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS), Santé de la vigne et qualité du vin (SVQV), Institut National de la Recherche Agronomique (INRA)-Université de Strasbourg (UNISTRA), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), and Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
natural enemies' susceptibility, [SDE]Environmental Sciences, food and beverages, densovirus infection, biochemical phenomena, metabolism, and nutrition, physiological costs, behavioural defences, life-history traits
Abstract

International audience; Microbial endosymbionts alter the phenotype of their host which may have cascading effects at both population and community levels. However, we currently lack information on whether the effects of viruses on both host phenotypic traits and host population demography can modify interactions with upper trophic levels. To fill this gap, we investigated whether a prevalent densovirus infecting the aphid Myzus persicae (i.e. MpDNV) can modify trophic interactions between host aphids and their natural enemies (i.e. predators and parasitoids) by influencing aphid phenotypic traits (i.e. body mass and defensive behaviours), population demography (i.e. density and age-structure) and susceptibility towards both predation and parasitism. We found that the virus decreased aphid body mass but did not influence their behavioural defences. At the population level, the virus had a minor effect on aphid adult mortality whereas it strongly reduced the density of nymphs and influenced the stage structure of aphid populations. In addition, the virus enhanced the susceptibility of aphids to parasitism regardless of the parasitoid species. Predation rate on adult aphids was not influenced by the virus but ladybeetle predators strongly decreased the number of aphid nymphs, especially for uninfected ones compared to infected ones. As a result, the virus decreased predator effect on aphid populations. By reducing both aphid quality and availability, increasing their susceptibility to parasitism, and modulating predator effect on aphid populations, we highlighted that viral endosymbionts can be prevalent drivers of their host ecology as they modify their phenotypes and interspecific interactions. These virus-mediated ecological effects may have consequences on enemies foraging strategies as well as trophic webs dynamics and structure.

Published
2019
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11. Correction

Author

Liu, Sijun, Bedford, Ian, Markham, Peter, Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J., Taiwo, M., Dijkstra, J., Martinez, B., López-Moya, J., Llave, C., Díaz-Ruíz, J., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., Pirone, T., Visser, Peter, Bol, John, Hernández, Carmen, Brown, Derek, Pappu, H., Culbreath, A., Todd, J., McPherson, R., Sherwood, J., Bertrand, P., Robbins, M., Reade, R., Rochon, D., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D., Vetten, H., Manqussopoulos, I., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef, Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I., Qu, Feng, Morris, T., Steinkellner, H., Puehringer, H., Machado, A., Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J., Bó, E., Torre, M., Djelouah, K., García, M., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y., Randles, J., Samson, A., Wilford, J., Chapman, S., Santa Cruz, S., Wilson, T., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B., Possee, R., French, T., Finkelstein, Y., Levi, B., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Lu, Liquan, Du, Quansheng, Watson, S., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E., Vlak, J., Heldens, J., Chejanovsky, N., Gershburg, E., Faruchi, S., Kamensky, B., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Zilberberg, N., Smith, P., King, L., Bamett, A., Windass, J., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L., Jarvis, D., Reilly, L., Hoover, K., Schultz, C., Hammock, B., Gordon, K., Bawden, A., Brooks, E., Lincoln, M., Hanzlik, T., Larkin, P., van Hulten, M., Hendry, D., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Phanis, Constantinos, O'Reilly, David, Clarke, E., Tristem, Michael, Cory, Jennifer, Mayo, M., Duncan, G., Reavy, B., Gildow, F., Lamb, J., Hay, R., Li, Shoudong, Qi, Bing, Wang, Jiawang, Kang, WonKyung, Crook, Norman, Winstanley, Doreen, Alaoui-Ismaili, M., Richardson, C., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan, Wang, S., Miller, W., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas, Hull, Roger, Hohn, Thomas, Hefferon, K., AbouHaider, M., Hulanicka, D., Juszczuk, M., Iskakov, B., Shmanov, M., Polimbetova, N., Zhanybekova, S., Lee, A., Galiakparov, N., Dale, J., Beetham, P., Hafner, G., and Harding, R.

Published
2018

12. The Aphid-Transmitted Turnip yellows virus Differentially Affects Volatiles Emission and Subsequent Vector Behavior in Two Brassicaceae Plants

Author

Claudel, P., Quentin Chesnais, Fouché, Q., Krieger, C., Halter, D., Bogaert, F., Meyer, S., Boissinot, S., Hugueney, P., Ziegler-Graff, V., Ameline, A., Brault, V., Santé de la vigne et qualité du vin (SVQV), Institut National de la Recherche Agronomique (INRA)-Université de Strasbourg (UNISTRA), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), French National Agency (ANR). Project VIRAPHIPLANT [ANR-14-CE19-0010-01], and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Volatile Organic Compounds, Brassicaceae, fungi, Arabidopsis, food and beverages, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Brassica, Luteoviridae, polerovirus, Article, Insect Vectors, Plant Viruses, lcsh:Chemistry, aphids, volatiles, lcsh:Biology (General), lcsh:QD1-999, Animals, Herbivory, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, Plant Diseases
Abstract

International audience; Aphids are important pests which cause direct damage by feeding or indirect prejudice by transmitting plant viruses. Viruses are known to induce modifications of plant cues in ways that can alter vector behavior and virus transmission. In this work, we addressed whether the modifications induced by the aphid-transmitted Turnip yellows virus (TuYV) in the model plant Arabidopsis thaliana also apply to the cultivated plant Camelina sativa, both belonging to the Brassicaceae family. In most experiments, we observed a significant increase in the relative emission of volatiles from TuYV-infected plants. Moreover, due to plant size, the global amounts of volatiles emitted by C. sativa were higher than those released by A. thaliana. In addition, the volatiles released by TuYV-infected C. sativa attracted the TuYV vector Myzus persicae more efficiently than those emitted by non-infected plants. In contrast, no such preference was observed for A. thaliana. We propose that high amounts of volatiles rather than specific metabolites are responsible for aphid attraction to infected C. sativa. This study points out that the data obtained from the model pathosystem A. thaliana/TuYV cannot be straightforwardly extrapolated to a related plant species infected with the same virus.

Published
2018
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13. Abstracts of presentations on plant protection issues at the xth international congress of virology: August 11-16, 1996 Binyanei haOoma, Jerusalem Iarael part 3(final part)

Author

Liu, Sijun, Bedford, Ian, Markham, Peter, Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J., Taiwo, M., Dijkstra, J., Martinez, B., López-Moya, J., Llave, C., Díaz-Ruíz, J., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., Pirone, T., Visser, Peter, Bol, John, Hernández, Carmen, Brown, Derek, Pappu, H., Culbreath, A., Todd, J., McPherson, R., Sherwood, J., Bertrand, P., Robbins, M., Reade, R., Rochon, D., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D., Vetten, H., Manqussopoulos, I., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef, Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I., Qu, Feng, Morris, T., Steinkellner, H., Puehringer, H., Machado, A., Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J., Bó, E., Torre, M., Djelouah, K., García, M., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y., Randles, J., Samson, A., Wilford, J., Chapman, S., Santa Cruz, S., Wilson, T., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B., Possee, R., French, T., Finkelstein, Y., Levi, B., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Lu, Liquan, Du, Quansheng, Watson, S., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E., Vlak, J., Heldens, J., Chejanovsky, N., Gershburg, E., Faruchi, S., Kamensky, B., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Zilberberg, N., Smith, P., King, L., Bamett, A., Windass, J., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L., Jarvis, D., Reilly, L., Hoover, K., Schultz, C., Hammock, B., Gordon, K., Bawden, A., Brooks, E., Lincoln, M., Hanzlik, T., Larkin, P., van Hulten, M., Hendry, D., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Phanis, Constantinos, O'Reilly, David, Clarke, E., Tristem, Michael, Cory, Jennifer, Mayo, M., Duncan, G., Reavy, B., Gildow, F., Lamb, J., Hay, R., Li, Shoudong, Qi, Bing, Wang, Jiawang, Kang, WonKyung, Crook, Norman, Winstanley, Doreen, Alaoui-Ismaili, M., Richardson, C., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan, Wang, S., Miller, W., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas, Hull, Roger, Hohn, Thomas, Hefferon, K., AbouHaider, M., Hulanicka, D., Juszczuk, M., Iskakov, B., Shmanov, M., Polimbetova, N., Zhanybekova, S., Lee, A., Galiakparov, N., Dale, J., Beetham, P., Hafner, G., Harding, R., Liu, Sijun, Bedford, Ian, Markham, Peter, Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J., Taiwo, M., Dijkstra, J., Martinez, B., López-Moya, J., Llave, C., Díaz-Ruíz, J., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., Pirone, T., Visser, Peter, Bol, John, Hernández, Carmen, Brown, Derek, Pappu, H., Culbreath, A., Todd, J., McPherson, R., Sherwood, J., Bertrand, P., Robbins, M., Reade, R., Rochon, D., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D., Vetten, H., Manqussopoulos, I., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef, Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I., Qu, Feng, Morris, T., Steinkellner, H., Puehringer, H., Machado, A., Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J., Bó, E., Torre, M., Djelouah, K., García, M., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y., Randles, J., Samson, A., Wilford, J., Chapman, S., Santa Cruz, S., Wilson, T., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B., Possee, R., French, T., Finkelstein, Y., Levi, B., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Lu, Liquan, Du, Quansheng, Watson, S., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E., Vlak, J., Heldens, J., Chejanovsky, N., Gershburg, E., Faruchi, S., Kamensky, B., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Zilberberg, N., Smith, P., King, L., Bamett, A., Windass, J., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L., Jarvis, D., Reilly, L., Hoover, K., Schultz, C., Hammock, B., Gordon, K., Bawden, A., Brooks, E., Lincoln, M., Hanzlik, T., Larkin, P., van Hulten, M., Hendry, D., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Phanis, Constantinos, O'Reilly, David, Clarke, E., Tristem, Michael, Cory, Jennifer, Mayo, M., Duncan, G., Reavy, B., Gildow, F., Lamb, J., Hay, R., Li, Shoudong, Qi, Bing, Wang, Jiawang, Kang, WonKyung, Crook, Norman, Winstanley, Doreen, Alaoui-Ismaili, M., Richardson, C., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan, Wang, S., Miller, W., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas, Hull, Roger, Hohn, Thomas, Hefferon, K., AbouHaider, M., Hulanicka, D., Juszczuk, M., Iskakov, B., Shmanov, M., Polimbetova, N., Zhanybekova, S., Lee, A., Galiakparov, N., Dale, J., Beetham, P., Hafner, G., and Harding, R.

Published
2018

14. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Author

Hrabe de Angelis, M. (M), Nicholson, G. (G), Selloum, M. (Mohammed), White, J. (J) K. (K), Morgan, H. (H), Ramirez-Solis, R. (R), Sorg, T. (Tania), Wells, S. (S), Fuchs, H. (H), Fray, M. (M), Adams, D. (D) J. (J), Adams, N. (N) C. (C), Adler, T. (T), Aguilar-Pimentel, A. (A), Ali-Hadji, D. (Dalila), Amann, G. (Grégory), Andre, P. (Philippe), Atkins, S. (S), Auburtin, A. (Aurélie), Ayadi, A. (Abdelkader), Becker, J. (Julien), Becker, L. (L), Bedu, E. (Elodie), Bekeredjian, R. (R), Birling, M. (Marie-Christine), Blake, A. (A), Bottomley, J. (J), Bowl, M. (M) R. (R), Brault, V. (Véronique), Busch, D. (D) H. (H), Bussell, J. (J) N. (N), Calzada-Wack, J. (J), Cater, H. (H), Champy, M. (Marie-France), Charles, P. (Philippe), Chevalier, C. (Claire), Chiani, F. (F), Codner, G. (G) F. (F), Combe, R. (R), Cox, R. (R), Dalloneau, E. (E), Dierich, A. (A), Di Fenza, A. (A), Doe, B. (B), Duchon, A. (Arnaud), Eickelberg, O. (O), Esapa, C. (C) T. (T), Fertak, L. (L) E. (E), Feigel, T. (T), Emelyanova, I. (I), Estabel, J. (J), Favor, J. (J), Flenniken, A. (A), Gambadoro, A. (A), Garrett, L. (L), Gates, H. (H), Gerdin, A. (A) K. (K), Gkoutos, G. (G), Greenaway, S. (S), Glasl, L. (L), Goetz, P. (P), Da Cruz, I. (I) G. (G), Gotz, A. (A), Graw, J. (J), Guimond, A. (Alain), Hans, W. (W), Hicks, G. (G), Holter, S. (S) M. (M), Hofler, H. (H), Hancock, J. (J) M. (M), Hoehndorf, R. (R), Hough, T. (T), Houghton, R. (R), Hurt, A. (A), Ivandic, B. (B), Jacobs, H. (Hugues), Jacquot, S. (Sylvie), Jones, N. (N), Karp, N. (N) A. (A), Katus, H. (H) A. (A), Kitchen, S. (S), Klein-Rodewald, T. (T), Klingenspor, M. (M), Klopstock, T. (T), Lalanne, V. (Valérie), Leblanc, S. (Sophie), Lengger, C. (C), le Marchand, E. (Elise), Ludwig, T. (T), Lux, A. (Aline), McKerlie, C. (C), Maier, H. (H), Mandel, J. (Jean-Louis), Marschall, S. (S), Mark, M. (Manuel), Melvin, D. (D) G. (G), Meziane, H. (Hamid), Micklich, K. (K), Mittelhauser, C. (C), Monassier, L. (Laurent), Moulaert, D. (David), Muller, S. (Stéphanie), Naton, B. (B), Neff, F. (F), Nolan, P. (P) M. (M), Nutter, L. (L) M. (M), Ollert, M. (M), Pavlovic, G. (Guillaume), Pellegata, N. (N) S. (S), Peter, E. (E), Petit-Demouliere, B. (Benoît), Pickard, A. (A), Podrini, C. (C), Potter, P. (P), Pouilly, L. (Laurent), Puk, O. (O), Richardson, D. (D), Rousseau, S. (Stéphane), Quintanilla-Fend, L. (L), Quwailid, M. (M) M. (M), Racz, I. (I), Rathkolb, B. (B), Riet, F. (Fabrice), Rossant, J. (J), Roux, M. (Michel), Rozman, J. (J), Ryder, E. (E), Salisbury, J. (J), Santos, L. (L), Schable, K. (K) H. (H), Schiller, E. (E), Schrewe, A. (A), Schulz, H. (H), Steinkamp, R. (R), Simon, M. (M), Stewart, M. (M), Stoger, C. (C), Stoger, T. (T), Sun, M. (M), Sunter, D. (D), Teboul, L. (L), Tilly, I. (I), Tocchini-Valentini, G. (G) P. (P), Tost, M. (M), Treise, I. (I), Vasseur, L. (Laurent), Velot, E. (E), Vogt-Weisenhorn, D. (D), Wagner, C. (Christel), Walling, A. (A), Wattenhofer-Donze, M. (Marie), Weber, B. (Bruno), Wendling, O. (Olivia), Westerberg, H. (H), Willershauser, M. (M), Wolf, E. (E), Wolter, A. (A), Wood, J. (J), Wurst, W. (W), Yildirim, A. (A) O. (O), Zeh, R. (R), Zimmer, A. (A), Zimprich, A. (A), Consortium, E. (Eumodic), Holmes, C. (C), Steel, K. (K) P. (P), Herault, Y. (Yann), Gailus-Durner, V. (V), Mallon, A. (A) M. (M), and Brown, S. (S) D. (D)

Subjects
Genetics, Male, Mice, Knockout, Heterozygote, Mutant, Homozygote, Aucun, Molecular Sequence Annotation, Biology, Phenotype, Mice, Inbred C57BL, Pleiotropy, ddc:570, Mutation, Animals, Humans, Human genome, Female, Allele, Gene, Gene knockout, Genetic Association Studies
Abstract

The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems. Comment in : Genetic differential calculus. [Nat Genet. 2015] Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015]

Published
2015
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15. Correction

Author

Liu, Sijun, Bedford, Ian D., Markham, Peter G., Ghanim, Morad, Zeidan, Muhamad, Czosnek, Henryk, Bruyère, A., Herrbach, E., Brault, V., Ziegler-Graff, V., Guilley, H., van den Heuvel, J. F. J. M., Taiwo, M. A., Dijkstra, J., Martinez, B., López-Moya, J. J., Llave, C., Díaz-Ruíz, J. R., López-Abella, D., Mikoshiba, Y., Honda, K., Kanematsu, S., Fujisawa, I., Salomon, Raffi, Bernardi, Francoise, Raccah, B., Singer, S., Gal-On, A., Huet, H., López-Moya, J. J., Pirone, T. P., Visser, Peter B., Bol, John F., Hernández, Carmen, Brown, Derek J. F., Pappu, H. R., Culbreath, A. K., Todd, J. W., McPherson, R. M., Sherwood, J. L., Bertrand, P. F., Robbins, M. A., Reade, R. D., Rochon, D. M., Schönfelder, M., Körbler, M., Barg, E., Lesemann, D. -E., Vetten, H. J., Manqussopoulos, I. N., Tsagris, M., Maiss, E., Marczewski, W., Syller, J., Romero, Javier, Molina-Garcia, Antonio, Babin, Mar, Bujarski, Jozef J., Pogany, Judy, Zhang, L., Palukaitis, P., Kaplan, I. B., Qu, Feng, Morris, T. Jack, Steinkellner, H., Puehringer, H., Machado, A. M. Laimer da Câmara, Hammond, J., Brandt, S., Katinger, H., Himmler, G., Carrier, K., Hans, F., Wang, A., Sanfacon, H., Palkovics, László, Balázs, Ervin, Petrzik, K., Mráz, I., Fránová-Honetšlegrová, J., Kusiak, C., Berthome, R., Dinant, S., Astier, S., Albouy, J., Renou, J. P., Bó, E. Dal, Torre, M. E. Sánchez de la, Djelouah, K., García, M. L., Grau, O., Benvenisti, Luna, Gelman, Boris, Hai, Dalia, Yadin, Hagai, Stram, Yehuda, Becker, Yechiel, Čeřovská, N., Filigarová, M., Dědič, P., Nemchinov, L., Hadidi, A., Choi, Y. G., Randles, J. W., Samson, A. C. R., Wilford, J. N., Chapman, S., Santa Cruz, S., Wilson, T. M. A., Wilkinson, Nicola, Wilson, Louise, Marlow, Susan, King, Linda, Possee, Robert, Zhu, Fanxiu, Qi, Yipeng, Huang, Yongxiu, Hu, Jianhong, Oker-Blom, Christian, Keinänen, Kari, Chauhan, B. K., Possee, R. D., French, T. J., Finkelstein, Y., Levi, B. Z., Faktor, O., Toister-Achituv, Mira, Wang, Fushan, Qi, Yipeng, Huang, Yongxiu, Lu, Liquan, Du, Quansheng, Watson, S. K., Kalmakoff, J., Broer, R., Liu, Y., Zuidema, D., Strien, E. A. van, Vlak, J. M., Heldens, J. G. M., Chejanovsky, N., Gershburg, E., Toister-Achituv, Mira, Faruchi, S., Kamensky, B., Faktor, O., Faktor, O., Nahum, O., Stockholm, D., Rivkin, H., Gurevitz, M., Chejanovsky, N., Zilberberg, N., Gershburg, E., Stockholm, D., Rivkin, H., Chejanovsky, N., Gurevitz, M., Zilberberg, N., Gershburg, E., Smith, P., King, L. A., Bamett, A., Windass, J. D., Possee, R. D., Jacobs, C., Fielding, B., Davison, S., Kunjeku, E., Guarino, L. A., Jarvis, D. L., Reilly, L., Hoover, K., Schultz, C. M., Hammock, B. D., Gordon, K. H. J., Bawden, A. L., Brooks, E. M., Lincoln, M. R., Hanzlik, T. N., Larkin, P. J., Gordon, K. H. J., Bawden, A. L., van Hulten, M. C. W., Hanzlik, T. N., Hendry, D. A., Stephens, Rachel, Barnett, Anna, Thomas, Carole, Possee, Robert, King, Linda, Phanis, Constantinos, O’Reilly, David R., Clarke, E., Tristem, Michael, Cory, Jennifer, O’Reilly, David R., Mayo, M. A., Duncan, G. H., Reavy, B., Gildow, F. E., Lamb, J. W., Hay, R. T., Li, Shoudong, Qi, Bing, Wang, Jiawang, Qi, Yipeng, O’Reilly, David R., Kang, WonKyung, Crook, Norman E., Winstanley, Doreen, Alaoui-Ismaili, M. H., Richardson, C. D., Lundsgaard, T., Kobayashi, J., Kayama, T., Ikeda, N., Miyajima, S., Inouye, K., Kimura, T., Suzuki, N., Sugawara, M., Nuss, D. L., Matsuura, Y., Simón, Laureano, Guo, Huishan, García, Juan Antonio, Wang, S., Miller, W. A., Browning, K., Fütterer, Johannes, Potrykus, Ingo, Bao, Yiming, Li, Liu, Burns, Thomas M., Hull, Roger, Hohn, Thomas, Hefferon, K. L., AbouHaider, M. G., Hulanicka, D., Juszczuk, M., Iskakov, B. K., Shmanov, M. A., Polimbetova, N. S., Zhanybekova, S. Sh., Lee, A. V., Galiakparov, N. N., Dale, J. L., Beetham, P. R., Hafner, G. J., Harding, R. M., and Dale, J. L.

Published
1998
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16. Discovery of a small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses that is required for long-distance movement

Author

Smirnova, E., Firth, A.E., Miller, W.A., Scheidecker, D., Brault, V., Reinbold, C., Rakotondrafara Chung AM, B.Y.M., Ziegler-Graff, V., Institut de biologie moléculaire des plantes (IBMP), and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

17. Divergence of host range and biological properties divergences between natural isolate and full-length infectious cDNA clone of the Beet mild yellowing virus 2ITB

Author

Klein, E., Brault, V., Klein, D., Weyens , G., Lefebvre, M., Ziegler-Graff, V., Gilmer, D., Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de transgénose, Centre National de la Recherche Scientifique (CNRS), Laboratoire Montpelliérain d'Économie Théorique et Appliquée (LAMETA), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Laboratoire de Mathématiques d'Orsay (LM-Orsay), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013
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18. Genome sequence of the pea aphid Acyrthosiphon pisum

Author

Richards, S, Gibbs, RA, Gerardo, NM, Moran, N, Nakabachi, A, Stern, D, Tagu, D, Wilson, ACC, Muzny, D, Kovar, C, Cree, A, Chacko, J, Chandrabose, MN, Dao, MD, Dinh, HH, Gabisi, RA, Hines, S, Hume, J, Jhangian, SN, Joshi, V, Lewis, LR, Liu, Y-S, Lopez, J, Morgan, MB, Nguyen, NB, Okwuonu, GO, Ruiz, SJ, Santibanez, J, Wright, RA, Fowler, GR, Hitchens, ME, Lozado, RJ, Moen, C, Steffen, D, Warren, JT, Zhang, J, Nazareth, LV, Chavez, D, Davis, C, Lee, SL, Patel, BM, Pu, L-L, Bell, SN, Johnson, AJ, Vattathil, S, Jr, WRL, Shigenobu, S, Dang, PM, Morioka, M, Fukatsu, T, Kudo, T, Miyagishima, S-Y, Jiang, H, Worley, KC, Legeai, F, Gauthier, J-P, Collin, O, Zhang, L, Chen, H-C, Ermolaeva, O, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Maglott, D, Murphy, T, Pruitt, K, Sapojnikov, V, Souvorov, A, Thibaud-Nissen, F, Camara, F, Guigo, R, Stanke, M, Solovyev, V, Kosarev, P, Gilbert, D, Gabaldon, T, Huerta-Cepas, J, Marcet-Houben, M, Pignatelli, M, Moya, A, Rispe, C, Ollivier, M, Quesneville, H, Permal, E, Llorens, C, Futami, R, Hedges, D, Robertson, HM, Alioto, T, Mariotti, M, Nikoh, N, McCutcheon, JP, Burke, G, Kamins, A, Latorre, A, Moran, NA, Ashton, P, Calevro, F, Charles, H, Colella, S, Douglas, A, Jander, G, Jones, DH, Febvay, G, Kamphuis, LG, Kushlan, PF, Macdonald, S, Ramsey, J, Schwartz, J, Seah, S, Thomas, G, Vellozo, A, Cass, B, Degnan, P, Hurwitz, B, Leonardo, T, Koga, R, Altincicek, B, Anselme, C, Atamian, H, Barribeau, SM, de Vos, M, Duncan, EJ, Evans, J, Ghanim, M, Heddi, A, Kaloshian, I, Vincent-Monegat, C, Parker, BJ, Perez-Brocal, V, Rahbe, Y, Spragg, CJ, Tamames, J, Tamarit, D, Tamborindeguy, C, Vilcinskas, A, Bickel, RD, Brisson, JA, Butts, T, Chang, C-C, Christiaens, O, Davis, GK, Duncan, E, Ferrier, D, Iga, M, Janssen, R, Lu, H-L, McGregor, A, Miura, T, Smagghe, G, Smith, J, van der Zee, M, Velarde, R, Wilson, M, Dearden, P, Edwards, OR, Gordon, K, Hilgarth, RS, Jr, RSD, Srinivasan, D, Walsh, TK, Ishikawa, A, Jaubert-Possamai, S, Fenton, B, Huang, W, Rizk, G, Lavenier, D, Nicolas, J, Smadja, C, Zhou, J-J, Vieira, FG, He, X-L, Liu, R, Rozas, J, Field, LM, Ashton, PD, Campbell, P, Carolan, JC, Douglas, AE, Fitzroy, CIJ, Reardon, KT, Reeck, GR, Singh, K, Wilkinson, TL, Huybrechts, J, Abdel-latief, M, Robichon, A, Veenstra, JA, Hauser, F, Cazzamali, G, Schneider, M, Williamson, M, Stafflinger, E, Hansen, KK, Grimmelikhuijzen, CJP, Price, DRG, Caillaud, M, van Fleet, E, Ren, Q, Gatehouse, JA, Brault, V, Monsion, B, Diaz, J, Hunnicutt, L, Ju, H-J, Pechuan, X, Aguilar, J, Cortes, T, Ortiz-Rivas, B, Martinez-Torres, D, Dombrovsky, A, Dale, RP, Davies, TGE, Williamson, MS, Jones, A, Sattelle, D, Williamson, S, Wolstenholme, A, Cottret, L, Sagot, MF, Heckel, DG, Hunter, W, Consortium, IAG, Universitat de Barcelona, Princeton University, Biologie des organismes et des populations appliquées à la protection des plantes (BIO3P), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-AGROCAMPUS OUEST, Biologie Fonctionnelle, Insectes et Interactions (BF2I), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), Baylor College of Medicine (BCM), Baylor University, An algorithmic view on genomes, cells, and environments (BAMBOO), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), IAGC, Institut National de la Recherche Agronomique (INRA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon, Eisen, Jonathan A., and Eisen, Jonathan A

Subjects
0106 biological sciences, TANDEM REPEATS, Genome, Insect, Gene Transfer, RRES175, Sequència genòmica, Faculty of Science\Computer Science, CPG METHYLATION, 01 natural sciences, Genome, Medical and Health Sciences, International Aphid Genomics Consortium, Biologiska vetenskaper, Biology (General), GENE-EXPRESSION, 2. Zero hunger, Genetics, 0303 health sciences, Aphid, Afídids, General Neuroscience, GENOME SEQUENCE, food and beverages, DROSOPHILA CIRCADIAN CLOCK, Biological Sciences, Genetics and Genomics/Microbial Evolution and Genomics, INSECTE, Genètica microbiana, puceron, APIS-MELLIFERA, General Agricultural and Biological Sciences, Infection, symbiose, Biotechnology, Research Article, VIRUS VECTORING, 175_Genetics, SYMBIOTIC BACTERIA, Gene Transfer, Horizontal, QH301-705.5, ACYRTHOSIPHON PISUM, Biology, HOLOMETABOLOUS INSECTS, HOST-PLANT, 010603 evolutionary biology, PEA APHID, INSECT-PLANT, PHENOTYPIC PLASTICITY, RAVAGEUR DES CULTURES, SOCIAL INSECT, General Biochemistry, Genetics and Molecular Biology, Horizontal, 03 medical and health sciences, Buchnera, Gene family, Life Science, Animals, Symbiosis, Gene, 030304 developmental biology, Whole genome sequencing, General Immunology and Microbiology, Annotation, Genome sequence, Agricultural and Veterinary Sciences, 175_Entomology, Genètica animal, Bacteriocyte, génome, gène, Human Genome, Biology and Life Sciences, 15. Life on land, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, REPETITIVE ELEMENTS, DNA-SEQUENCES, Acyrthosiphon pisum, Genome Sequence, Genetics and Genomics/Genome Projects, Aphids, PHEROMONE-BINDING, Insect, Developmental Biology, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

The genome of the pea aphid shows remarkable levels of gene duplication and equally remarkable gene absences that shed light on aspects of aphid biology, most especially its symbiosis with Buchnera., Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems., Author Summary Aphids are common pests of crops and ornamental plants. Facilitated by their ancient association with intracellular symbiotic bacteria that synthesize essential amino acids, aphids feed on phloem (sap). Exploitation of a diversity of long-lived woody and short-lived herbaceous hosts by many aphid species is a result of specializations that allow aphids to discover and exploit suitable host plants. Such specializations include production by a single genotype of multiple alternative phenotypes including asexual, sexual, winged, and unwinged forms. We have generated a draft genome sequence of the pea aphid, an aphid that is a model for the study of symbiosis, development, and host plant specialization. Some of the many highlights of our genome analysis include an expanded total gene set with remarkable levels of gene duplication, as well as aphid-lineage-specific gene losses. We find that the pea aphid genome contains all genes required for epigenetic regulation by methylation, that genes encoding the synthesis of a number of essential amino acids are distributed between the genomes of the pea aphid and its symbiont, Buchnera aphidicola, and that many genes encoding immune system components are absent. These genome data will form the basis for future aphid research and have already underpinned a variety of genome-wide approaches to understanding aphid biology.

Published
2010
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19. Phloem protein partners of Curcubit aphid borne yellows virus: possible involvement of phloem proteins in virus transmission by aphids

Author

Bencharki, B., Boissinot, S., Revollon, S., Ziegler-Graff, V., Erdinger, M., Wiss, L., Dinant, S., Renard, D., Beuve, M., Lemaître-Guillier, C., Brault, V., Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de transgénose, Centre National de la Recherche Scientifique (CNRS), and Noirtin, Francine

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

21. Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development

Author

Kioussi, C., Briata, P., Sh, Baek, Dw, Rose, Ns, Hamblet, Herman, T., Ka, Ohgi, Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Hd, Nguyen, Kemler, R., And Rosenfeld, A., Immunologie et Embryologie Moléculaires (IEM), and Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BDD]Life Sciences [q-bio]/Development Biology
Published
2003

22. A new virus infecting Myzus persicae has a genome organization similar to the species of the genus Densovirus

Author

van Munster, M., Dullemans, A.M., Verbeek, M., van den Heuvel, J.F.J.M., Reinbold, C., Brault, V., Clérivet, A., van der Wilk, F., Plant Research International, Wageningen University and Research [Wageningen] (WUR), De Ruiter Seeds, Partenaires INRAE, Unité de recherche biologie des interactions virus vecteur, Institut National de la Recherche Agronomique (INRA), and Institut de Recherche pour le Développement (IRD [Réunion])

Subjects
replication, parvoviruses, viruses, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Genome, Viral, dna, densonucleosis virus, Open Reading Frames, Viral Proteins, complete nucleotide-sequence, expression, Animals, Densovirus, initiator, Amino Acid Sequence, Promoter Regions, Genetic, Phylogeny, Biointeracties and Plant Health, Base Sequence, DNA Viruses, alignment, Sequence Analysis, DNA, periplaneta-fuliginosa, Plant Research International, Aphids, PRI Biointeractions en Plantgezondheid, RNA Splice Sites, transcription
Abstract

The genomic sequence of a new icosahedral DNA virus infecting Myzus persicae has been determined. Analysis of 5499 nt of the viral genome revealed five open reading frames (ORFs) evenly distributed in the 5' half of both DNA strands. Three ORFs (ORF1-3) share the same strand, while two other ORFs (ORF4 and ORF5) are detected in the complementary sequence. The overall genomic organization is similar to that of species from the genus Densovirus. ORFs 1-3 most likely encode the non-structural proteins, since their putative products contain conserved replication motifs, NTP-binding domains and helicase domains similar to those found in the NS-1 protein of parvoviruses. The deduced amino acid sequences from ORFs 4 and 5 show sequence similarities with the structural proteins of the members of the genus Densovirus. These data indicate that this virus is a new species of the genus Densovirus in the family Parvoviridae. The virus was tentatively named Myzus persicae densovirus. The nucleotide sequence reported in this study appears in the EMBL, GenBank and DDBJ nucleotide sequence databases under accession number AY148187.

Published
2003
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23. Lineage-specific requirements of beta-catenin in neural crest development

Author

Hari, L., Brault, V., Kleber, M., Hy, Lee, Ille, F., Leimeroth, R., Paratore, C., Suter, U., Kemler, R., Sommer, L., Immunologie et Embryologie Moléculaires (IEM), and Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BDD]Life Sciences [q-bio]/Development Biology
Published
2003

26. Role of the 3'-proximal genes in beet western yellows luteovirus movement in plants

Author

Mutterer, Jérome, Ziegler-Graff, Véronique, Brault, V., Herrbach, Etienne, Jonard, G., Guilley, H., Richards, K., ProdInra, Migration, Station de recherches grandes cultures : Laboratoire de zoologie, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], BIOLOGIE MOLECULAIRE
Published
1997

28. Molecular bases of luteovirus transmission by aphids

Author

Richards, K.E., Bruyere, A., Brault, V., Ziegler-Graff, Véronique, Herrbach, Etienne, van den Heuvel, J.F.J., Jonard, J.F.J., Guilley, H., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, BIOLOGIE MOLECULAIRE
Published
1996

29. Molecular studies of luteovirus transmission by aphids

Author

Ziegler-Graff, Véronique, Bruyere, A., Brault, V., van den Heuvel, J.F.J.M., Herrbach, Etienne, Guilley, H., Jonard, G., Richards, K., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, BIOLOGIE MOLECULAIRE
Published
1996

30. Molecular determinants governing beet western yellows virus transmission by aphids

Author

Bruyere, A., Brault, V., Ziegler-Graff, Véronique, Herrbach, Etienne, van den Heuvel, J.F., Guilley, H., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, BEET WESTERN YELLOWS LUTEOVIRUS, BIOLOGIE MOLECULAIRE, VIROLOGIE
Published
1996

31. How many movement proteins do luteoviruses require for efficient infection ?

Author

Ziegler-Graff, Véronique, Brault, V., Mutterer, Jérome, Herrbach, Etienne, Jonard, G., Guilley, H., Richards, K., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VIROLOGIE
Published
1996

32. Mutational analysis of the genes required for a luteovirus to move and infect plants

Author

Mutterer, Jérome, Brault, V., Ziegler-Graff, Véronique, Bruyere, A., Herrbach, Etienne, Jonard, G., Guilley, H., Richards, K., ProdInra, Migration, Station de recherches grandes cultures : Laboratoire de zoologie, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
1996

33. Studies on the interrelations between beet western yellows luteovirus (BWYV) and its aphid vector

Author

Bruyere, A., Herrbach, Etienne, Lemaire, Olivier, Reinbold, Catherine, Brault, V., Ziegler-Graff, Véronique, Guilley, H., Richards, K., Jonard, G., van Den Heuvel, H., ProdInra, Migration, Station de recherches grandes cultures : Laboratoire de zoologie, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR
Published
1996

34. Aphid transmission of beet western yellows luteovirus requires the minor capsid readthrough protein

Author

Ziegler-Graff, Véronique, Brault, V., van Den Heuvel, J.F.J.M., Verbeek, M., Reutenauer, A., Herrbach, Etienne, Bruyere, A., Garaud, J.C., Guilley, H., Jonard, G., Richards, K., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, VIROLOGIE
Published
1995

35. Study of the domains of the readthrough protein involved in beet western yellowing luteovirus transmission by Myzus persicae

Author

Brault, V., Bruyere, A., van den Heuvel, J.F.J.M., Verbeek, M., Ziegler-Graff, Véronique, Lemaire, Olivier, Herrbach, Etienne, Garaud, J.C., Guilley, H., Richards, K., Jonard, G., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), Station de recherches vigne et vin : Laboratoire de pathologie végétale, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, VIROLOGIE
Published
1995

36. La transmission du beet western yellows luteovirus par le puceron Myzus persicae nécessite la protéine de readthrough P74

Author

Brault, V., Bruyere, A., van Den Heuvel, J.F.J.M., Lemaire, Olivier, Ziegler-Graff, Véronique, Herrbach, Etienne, Garaud, J.C., Guilley, H., Richards, K., Joanrd, G., Station de recherches grandes cultures : Laboratoire de zoologie, Institut National de la Recherche Agronomique (INRA), Station de recherches vigne et vin : Laboratoire de pathologie végétale, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR
Published
1995

42. Agroinfection : a way to study aphid transmission of Beet Western Yellows luteovirus

Author

Brault, V., Reutenauer, A., Ziegler-Graff, Véronique, Herrbach, Etienne, Richards, K., Jonard, G., ProdInra, Migration, Station de recherches grandes cultures : Laboratoire de zoologie, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], VECTEUR, AGROINFECTION
Published
1993

46. Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome.

Author

Starke, K., Born, G. V. R., Duckles, S., Eichelbaum, M., Ganten, D., Hofmann, F., Rosenthal, W., Rubanyi, G., Feil, Robert, Metzger, Daniel, Brault, V., Besson, V., Magnol, L., Duchon, A., and Hérault, Y.

Abstract

Together with numerous other genome modifications, chromosome engineering offers a very powerful tool to accelerate the functional analysis of the mammalian genome. The technology, based on the Cre/loxP system, is used more and more in the scientific community in order to generate new chromosomes carrying deletions, duplications, inversions and translocations in targeted regions of interest. In this review, we will present the basic principle of the technique either in vivo or in vitro and we will briefly describe some applications to provide highly valuable genetic tools, to decipher the mammalian genome organisation and to analyze human diseases in the mouse. [ABSTRACT FROM AUTHOR]

Published
2007
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