1. Polyfunctionalized organoselenides: New synthetic approach from selenium-containing cyanohydrins and anti-melanoma activity.
- Author
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Clara da Silva Durigon M, Renata Caitano Visnheski B, Braz Júnior O, Christina Thomas J, Fogagnoli Simas F, and Piovan L
- Subjects
- Animals, Mice, Anhydrides chemistry, Anhydrides pharmacology, BALB 3T3 Cells, Cell Line, Tumor, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Melanoma drug therapy, Melanoma pathology, Melanoma, Experimental drug therapy, Melanoma, Experimental pathology, Molecular Structure, Selenium chemistry, Selenium pharmacology, Structure-Activity Relationship, Acetates chemical synthesis, Acetates chemistry, Acetates pharmacology, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Nitriles chemistry, Nitriles pharmacology, Nitriles chemical synthesis, Organoselenium Compounds chemistry, Organoselenium Compounds pharmacology, Organoselenium Compounds chemical synthesis
- Abstract
A series of seleno-containing polyfunctionalized compounds was synthesized exploring cyanohydrin chemistry, including α-hydroxy esters, α-hydroxy acids, 1,2-diols, and 1,2-diacetates, with yields ranging from 26 up to 99 %. The cytotoxicity of all synthesized compounds was then evaluated using a non-tumor cell line (BALB/3T3 murine fibroblasts), and those deemed non-cytotoxic had their anti-melanoma activity evaluated using B16-F10 murine melanoma cells. These assays identified two compounds with selective cytotoxic activity against the tested melanoma cell line, showing a potential anti-melanoma application., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Leandro Piovan reports financial support was provided by Federal University of Parana. Leandro Piovan reports a relationship with Federal University of Parana that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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